Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:APP-NARG2 (FusionGDB2 ID:HG351TG79664)

Fusion Gene Summary for APP-NARG2

check button Fusion gene summary
Fusion gene informationFusion gene name: APP-NARG2
Fusion gene ID: hg351tg79664
HgeneTgene
Gene symbol

APP

NARG2

Gene ID

351

79664

Gene nameamyloid beta precursor proteininteractor of little elongation complex ELL subunit 2
SynonymsAAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4BRCC1|NARG2
Cytomap('APP')('NARG2')

21q21.3

15q22.2

Type of geneprotein-codingprotein-coding
Descriptionamyloid-beta precursor proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor proteilittle elongation complex subunit 2NMDA receptor regulated 2NMDA receptor-regulated gene 2NMDA receptor-regulated protein 2breast cancer cell 1interactor of little elongator complex ELL subunit 2
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000346798, ENST00000348990, 
ENST00000354192, ENST00000357903, 
ENST00000359726, ENST00000439274, 
ENST00000440126, ENST00000448388, 
ENST00000358918, ENST00000474136, 
Fusion gene scores* DoF score31 X 25 X 12=93002 X 2 X 2=8
# samples 332
** MAII scorelog2(33/9300*10)=-4.81669278663694
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: APP [Title/Abstract] AND NARG2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPP(27277335)-NARG2(60728426), # samples:1
Anticipated loss of major functional domain due to fusion event.APP-NARG2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APP-NARG2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APP-NARG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APP-NARG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPP

GO:0001934

positive regulation of protein phosphorylation

11404397

HgeneAPP

GO:0008285

negative regulation of cell proliferation

22944668

HgeneAPP

GO:1905606

regulation of presynapse assembly

19726636


check buttonFusion gene breakpoints across APP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NARG2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-EQ-A4SOAPPchr21

27277335

-NARG2chr15

60728426

-


Top

Fusion Gene ORF analysis for APP-NARG2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000346798ENST00000558654APPchr21

27277335

-NARG2chr15

60728426

-
5CDS-intronENST00000346798ENST00000561114APPchr21

27277335

-NARG2chr15

60728426

-
5CDS-intronENST00000348990ENST00000558654APPchr21

27277335

-NARG2chr15

60728426

-
5CDS-intronENST00000348990ENST00000561114APPchr21

27277335

-NARG2chr15

60728426

-
5CDS-intronENST00000354192ENST00000558654APPchr21

27277335

-NARG2chr15

60728426

-
5CDS-intronENST00000354192ENST00000561114APPchr21

27277335

-NARG2chr15

60728426

-
5CDS-intronENST00000357903ENST00000558654APPchr21

27277335

-NARG2chr15

60728426

-
5CDS-intronENST00000357903ENST00000561114APPchr21

27277335

-NARG2chr15

60728426

-
5CDS-intronENST00000359726ENST00000558654APPchr21

27277335

-NARG2chr15

60728426

-
5CDS-intronENST00000359726ENST00000561114APPchr21

27277335

-NARG2chr15

60728426

-
5CDS-intronENST00000439274ENST00000558654APPchr21

27277335

-NARG2chr15

60728426

-
5CDS-intronENST00000439274ENST00000561114APPchr21

27277335

-NARG2chr15

60728426

-
5CDS-intronENST00000440126ENST00000558654APPchr21

27277335

-NARG2chr15

60728426

-
5CDS-intronENST00000440126ENST00000561114APPchr21

27277335

-NARG2chr15

60728426

-
5CDS-intronENST00000448388ENST00000558654APPchr21

27277335

-NARG2chr15

60728426

-
5CDS-intronENST00000448388ENST00000561114APPchr21

27277335

-NARG2chr15

60728426

-
In-frameENST00000346798ENST00000261520APPchr21

27277335

-NARG2chr15

60728426

-
In-frameENST00000346798ENST00000439632APPchr21

27277335

-NARG2chr15

60728426

-
In-frameENST00000348990ENST00000261520APPchr21

27277335

-NARG2chr15

60728426

-
In-frameENST00000348990ENST00000439632APPchr21

27277335

-NARG2chr15

60728426

-
In-frameENST00000354192ENST00000261520APPchr21

27277335

-NARG2chr15

60728426

-
In-frameENST00000354192ENST00000439632APPchr21

27277335

-NARG2chr15

60728426

-
In-frameENST00000357903ENST00000261520APPchr21

27277335

-NARG2chr15

60728426

-
In-frameENST00000357903ENST00000439632APPchr21

27277335

-NARG2chr15

60728426

-
In-frameENST00000359726ENST00000261520APPchr21

27277335

-NARG2chr15

60728426

-
In-frameENST00000359726ENST00000439632APPchr21

27277335

-NARG2chr15

60728426

-
In-frameENST00000439274ENST00000261520APPchr21

27277335

-NARG2chr15

60728426

-
In-frameENST00000439274ENST00000439632APPchr21

27277335

-NARG2chr15

60728426

-
In-frameENST00000440126ENST00000261520APPchr21

27277335

-NARG2chr15

60728426

-
In-frameENST00000440126ENST00000439632APPchr21

27277335

-NARG2chr15

60728426

-
In-frameENST00000448388ENST00000261520APPchr21

27277335

-NARG2chr15

60728426

-
In-frameENST00000448388ENST00000439632APPchr21

27277335

-NARG2chr15

60728426

-
intron-3CDSENST00000358918ENST00000261520APPchr21

27277335

-NARG2chr15

60728426

-
intron-3CDSENST00000358918ENST00000439632APPchr21

27277335

-NARG2chr15

60728426

-
intron-3CDSENST00000474136ENST00000261520APPchr21

27277335

-NARG2chr15

60728426

-
intron-3CDSENST00000474136ENST00000439632APPchr21

27277335

-NARG2chr15

60728426

-
intron-intronENST00000358918ENST00000558654APPchr21

27277335

-NARG2chr15

60728426

-
intron-intronENST00000358918ENST00000561114APPchr21

27277335

-NARG2chr15

60728426

-
intron-intronENST00000474136ENST00000558654APPchr21

27277335

-NARG2chr15

60728426

-
intron-intronENST00000474136ENST00000561114APPchr21

27277335

-NARG2chr15

60728426

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000346798APPchr2127277335-ENST00000439632NARG2chr1560728426-65461997342520828
ENST00000346798APPchr2127277335-ENST00000261520NARG2chr1560728426-65461997342520828
ENST00000354192APPchr2127277335-ENST00000439632NARG2chr1560728426-624616971272220697
ENST00000354192APPchr2127277335-ENST00000261520NARG2chr1560728426-624616971272220697
ENST00000348990APPchr2127277335-ENST00000439632NARG2chr1560728426-643418851472408753
ENST00000348990APPchr2127277335-ENST00000261520NARG2chr1560728426-643418851472408753
ENST00000357903APPchr2127277335-ENST00000439632NARG2chr1560728426-662220731672596809
ENST00000357903APPchr2127277335-ENST00000261520NARG2chr1560728426-662220731672596809
ENST00000359726APPchr2127277335-ENST00000439632NARG2chr1560728426-654419952002518772
ENST00000359726APPchr2127277335-ENST00000261520NARG2chr1560728426-654419952002518772
ENST00000448388APPchr2127277335-ENST00000439632NARG2chr1560728426-637418251682348726
ENST00000448388APPchr2127277335-ENST00000261520NARG2chr1560728426-637418251682348726
ENST00000440126APPchr2127277335-ENST00000439632NARG2chr1560728426-670621572392680813
ENST00000440126APPchr2127277335-ENST00000261520NARG2chr1560728426-670621572392680813
ENST00000439274APPchr2127277335-ENST00000439632NARG2chr1560728426-63781829342352772
ENST00000439274APPchr2127277335-ENST00000261520NARG2chr1560728426-63781829342352772

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000346798ENST00000439632APPchr2127277335-NARG2chr1560728426-0.0003243340.99967563
ENST00000346798ENST00000261520APPchr2127277335-NARG2chr1560728426-0.0003243340.99967563
ENST00000354192ENST00000439632APPchr2127277335-NARG2chr1560728426-0.0002941870.99970573
ENST00000354192ENST00000261520APPchr2127277335-NARG2chr1560728426-0.0002941870.99970573
ENST00000348990ENST00000439632APPchr2127277335-NARG2chr1560728426-0.0004614360.99953854
ENST00000348990ENST00000261520APPchr2127277335-NARG2chr1560728426-0.0004614360.99953854
ENST00000357903ENST00000439632APPchr2127277335-NARG2chr1560728426-0.000327660.9996723
ENST00000357903ENST00000261520APPchr2127277335-NARG2chr1560728426-0.000327660.9996723
ENST00000359726ENST00000439632APPchr2127277335-NARG2chr1560728426-0.0005742030.99942577
ENST00000359726ENST00000261520APPchr2127277335-NARG2chr1560728426-0.0005742030.99942577
ENST00000448388ENST00000439632APPchr2127277335-NARG2chr1560728426-0.0005316960.99946827
ENST00000448388ENST00000261520APPchr2127277335-NARG2chr1560728426-0.0005316960.99946827
ENST00000440126ENST00000439632APPchr2127277335-NARG2chr1560728426-0.0003736630.9996263
ENST00000440126ENST00000261520APPchr2127277335-NARG2chr1560728426-0.0003736630.9996263
ENST00000439274ENST00000439632APPchr2127277335-NARG2chr1560728426-0.0002964810.99970347
ENST00000439274ENST00000261520APPchr2127277335-NARG2chr1560728426-0.0002964810.99970347

Top

Fusion Genomic Features for APP-NARG2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for APP-NARG2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:27277335/chr15:60728426)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-1518230_260654771.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-1518274_280654771.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-1316230_260579696.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-1316274_280579696.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-1215230_260523640.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-1215274_280523640.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-1417230_260635752.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-1417274_280635752.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-1417230_260598715.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-1417274_280598715.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-1417230_260630747.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-1417274_280630747.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-151828_189654771.0DomainE1
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-1518374_565654771.0DomainE2
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-131628_189579696.0DomainE1
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-1316374_565579696.0DomainE2
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-121528_189523640.0DomainE1
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-141728_189635752.0DomainE1
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-1417374_565635752.0DomainE2
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-141728_189598715.0DomainE1
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-1417374_565598715.0DomainE2
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-141728_189630747.0DomainE1
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-1417374_565630747.0DomainE2
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-1518344_365654771.0MotifOX-2
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-1316344_365579696.0MotifOX-2
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-1215344_365523640.0MotifOX-2
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-1417344_365635752.0MotifOX-2
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-1417344_365598715.0MotifOX-2
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-1417344_365630747.0MotifOX-2
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-1518131_189654771.0RegionCuBD subdomain
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-1518181_188654771.0RegionNote=Zinc-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-151828_123654771.0RegionGFLD subdomain
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-1518391_423654771.0RegionNote=Heparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-1518491_522654771.0RegionNote=Heparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-1518523_540654771.0RegionCollagen-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-151896_110654771.0RegionHeparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-1316131_189579696.0RegionCuBD subdomain
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-1316181_188579696.0RegionNote=Zinc-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-131628_123579696.0RegionGFLD subdomain
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-1316391_423579696.0RegionNote=Heparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-1316491_522579696.0RegionNote=Heparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-1316523_540579696.0RegionCollagen-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-131696_110579696.0RegionHeparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-1215131_189523640.0RegionCuBD subdomain
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-1215181_188523640.0RegionNote=Zinc-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-121528_123523640.0RegionGFLD subdomain
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-1215391_423523640.0RegionNote=Heparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-1215491_522523640.0RegionNote=Heparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-121596_110523640.0RegionHeparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-1417131_189635752.0RegionCuBD subdomain
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-1417181_188635752.0RegionNote=Zinc-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-141728_123635752.0RegionGFLD subdomain
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-1417391_423635752.0RegionNote=Heparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-1417491_522635752.0RegionNote=Heparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-1417523_540635752.0RegionCollagen-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-141796_110635752.0RegionHeparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-1417131_189598715.0RegionCuBD subdomain
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-1417181_188598715.0RegionNote=Zinc-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-141728_123598715.0RegionGFLD subdomain
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-1417391_423598715.0RegionNote=Heparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-1417491_522598715.0RegionNote=Heparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-1417523_540598715.0RegionCollagen-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-141796_110598715.0RegionHeparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-1417131_189630747.0RegionCuBD subdomain
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-1417181_188630747.0RegionNote=Zinc-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-141728_123630747.0RegionGFLD subdomain
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-1417391_423630747.0RegionNote=Heparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-1417491_522630747.0RegionNote=Heparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-1417523_540630747.0RegionCollagen-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-141796_110630747.0RegionHeparin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-117230_2600753.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-117274_2800753.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-1215374_565523640.0DomainE2
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-11728_1890753.0DomainE1
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-117374_5650753.0DomainE2
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-1518724_734654771.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-1316724_734579696.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-1215724_734523640.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-1417724_734635752.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-117344_3650753.0MotifOX-2
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-117724_7340753.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-1417724_734598715.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-1417724_734630747.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-1215523_540523640.0RegionCollagen-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-117131_1890753.0RegionCuBD subdomain
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-117181_1880753.0RegionNote=Zinc-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-11728_1230753.0RegionGFLD subdomain
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-117391_4230753.0RegionNote=Heparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-117491_5220753.0RegionNote=Heparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-117523_5400753.0RegionCollagen-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-11796_1100753.0RegionHeparin-binding
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-151818_701654771.0Topological domainExtracellular
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-1518723_770654771.0Topological domainCytoplasmic
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-131618_701579696.0Topological domainExtracellular
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-1316723_770579696.0Topological domainCytoplasmic
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-121518_701523640.0Topological domainExtracellular
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-1215723_770523640.0Topological domainCytoplasmic
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-141718_701635752.0Topological domainExtracellular
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-1417723_770635752.0Topological domainCytoplasmic
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-11718_7010753.0Topological domainExtracellular
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-117723_7700753.0Topological domainCytoplasmic
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-141718_701598715.0Topological domainExtracellular
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-1417723_770598715.0Topological domainCytoplasmic
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-141718_701630747.0Topological domainExtracellular
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-1417723_770630747.0Topological domainCytoplasmic
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-1518702_722654771.0TransmembraneHelical
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-1316702_722579696.0TransmembraneHelical
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-1215702_722523640.0TransmembraneHelical
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-1417702_722635752.0TransmembraneHelical
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-117702_7220753.0TransmembraneHelical
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-1417702_722598715.0TransmembraneHelical
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-1417702_722630747.0TransmembraneHelical


Top

Fusion Gene Sequence for APP-NARG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5699_5699_1_APP-NARG2_APP_chr21_27277335_ENST00000346798_NARG2_chr15_60728426_ENST00000261520_length(transcript)=6546nt_BP=1997nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGA
ACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCC
CCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGA
GAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGG
CATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGC
TGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGC
AGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGA
GGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGA
GGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATT
CTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTT
ACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCT
CGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGT
CATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGT
GGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCG
CCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCG
CGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCA
GGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCA
GGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGG
AAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCA
GCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGG
ACTGACCACTCGACCAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCT
TTCAGCACTCAAGATTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATC
TCATGCAGCAGAAGATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTG
CGGCCTTCCTGGTGTACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAG
AATACCTTGTACTTTTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAA
TCCAGTTTCCATGGAAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTG
AGGACTGTACCATGGAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAG
AGGAACATTTTTCCTGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCT
TTTCACCCTTGAAGTTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTA
AACCTTTTCTAAAAATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCC
AGTCTGTTGCGACTGACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGAC
AGTTTTTATATACTCCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCC
AAAAATAAAAACTCCCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGT
GGTATAACATGTTTGATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTT
TTCCAGAAAAAAAGTCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCG
CTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCT
CCCGAGTAGCTGGGACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGC
CGGGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCC
AGCATAAGCTATTTTTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGAT
GTTGCTGTAGCAAATTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAG
GCGGGAGAATCACTTGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGT
GGGGTGTGCCTGTAGTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCG
CACCACAGAACTCAGCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTT
ACACTAAAATTTTCAGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCT
ATTCTGTGTAAAGAATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATAC
TTATATTCAACTACCAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGT
ATCTTGATAAATCATTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTT
TGGTTGTGAATCATTTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTA
CATTTGTGTGCACCAGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTT
TAATTTTTAAATATTACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTT
GTGCTTAGTGAAGCCTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAG
AAGTAACTGACAATATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCT
GCAGTGAGCTATGATGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTT
TAAATCAGACTTAGGGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAA
AACAGTTTAATTCAGTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCA
GATCTCACCATATTTATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCA
TTAAGTAATAAACACCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTT
TTTTTTCAGGAGATCACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGAT
CTTGGTAGTTAAGGTTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAA
AGAAACTAAGTGAAACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCA
GGATAGGGACAGAAACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGAT
CAGATATGTATTTGAAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGT
GTTGTAGTAACTGAAAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAA
TGACAACTCAGTTTTGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCC
ATTGAGAAAATAGTGTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGT
TTGTGTGCTATATTGGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTT
TCTGTAAGTCAAAAGTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAA
GCCCACACTTAAGCTCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAG
GGGAGGGAGAGGAAAGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTT
TCTATGCATTATAGGTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTT

>5699_5699_1_APP-NARG2_APP_chr21_27277335_ENST00000346798_NARG2_chr15_60728426_ENST00000261520_length(amino acids)=828AA_BP=654
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT
SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANER
QQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVP
ANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIY
KASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCL

--------------------------------------------------------------
>5699_5699_2_APP-NARG2_APP_chr21_27277335_ENST00000346798_NARG2_chr15_60728426_ENST00000439632_length(transcript)=6546nt_BP=1997nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGA
ACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCC
CCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGA
GAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGG
CATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGC
TGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGC
AGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGA
GGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGA
GGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATT
CTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTT
ACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCT
CGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGT
CATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGT
GGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCG
CCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCG
CGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCA
GGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCA
GGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGG
AAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCA
GCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGG
ACTGACCACTCGACCAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCT
TTCAGCACTCAAGATTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATC
TCATGCAGCAGAAGATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTG
CGGCCTTCCTGGTGTACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAG
AATACCTTGTACTTTTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAA
TCCAGTTTCCATGGAAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTG
AGGACTGTACCATGGAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAG
AGGAACATTTTTCCTGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCT
TTTCACCCTTGAAGTTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTA
AACCTTTTCTAAAAATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCC
AGTCTGTTGCGACTGACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGAC
AGTTTTTATATACTCCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCC
AAAAATAAAAACTCCCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGT
GGTATAACATGTTTGATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTT
TTCCAGAAAAAAAGTCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCG
CTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCT
CCCGAGTAGCTGGGACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGC
CGGGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCC
AGCATAAGCTATTTTTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGAT
GTTGCTGTAGCAAATTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAG
GCGGGAGAATCACTTGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGT
GGGGTGTGCCTGTAGTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCG
CACCACAGAACTCAGCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTT
ACACTAAAATTTTCAGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCT
ATTCTGTGTAAAGAATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATAC
TTATATTCAACTACCAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGT
ATCTTGATAAATCATTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTT
TGGTTGTGAATCATTTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTA
CATTTGTGTGCACCAGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTT
TAATTTTTAAATATTACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTT
GTGCTTAGTGAAGCCTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAG
AAGTAACTGACAATATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCT
GCAGTGAGCTATGATGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTT
TAAATCAGACTTAGGGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAA
AACAGTTTAATTCAGTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCA
GATCTCACCATATTTATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCA
TTAAGTAATAAACACCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTT
TTTTTTCAGGAGATCACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGAT
CTTGGTAGTTAAGGTTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAA
AGAAACTAAGTGAAACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCA
GGATAGGGACAGAAACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGAT
CAGATATGTATTTGAAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGT
GTTGTAGTAACTGAAAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAA
TGACAACTCAGTTTTGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCC
ATTGAGAAAATAGTGTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGT
TTGTGTGCTATATTGGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTT
TCTGTAAGTCAAAAGTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAA
GCCCACACTTAAGCTCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAG
GGGAGGGAGAGGAAAGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTT
TCTATGCATTATAGGTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTT

>5699_5699_2_APP-NARG2_APP_chr21_27277335_ENST00000346798_NARG2_chr15_60728426_ENST00000439632_length(amino acids)=828AA_BP=654
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT
SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANER
QQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVP
ANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIY
KASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCL

--------------------------------------------------------------
>5699_5699_3_APP-NARG2_APP_chr21_27277335_ENST00000348990_NARG2_chr15_60728426_ENST00000261520_length(transcript)=6434nt_BP=1885nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGC
CGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGAC
AAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAG
AGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAA
GAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGT
GAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGT
GATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAG
TCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAAT
GAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCA
GAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCA
GCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTAC
ATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAG
CACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTG
ATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTT
CAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCT
TTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCT
GACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGGCAT
ATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTTCAGCACTCAAGATTTCCAAT
TTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTCATGCAGCAGAAGATTCTTCA
CTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCGGCCTTCCTGGTGTACCTTCC
AGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAATACCTTGTACTTTTCCACCG
AAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATCCAGTTTCCATGGAAACCAAA
AGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAGGACTGTACCATGGAAAACTA
AATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAGGAACATTTTTCCTGTAGTAG
CTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTTTCACCCTTGAAGTTTGAGGA
GGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAACCTTTTCTAAAAATTGTAAA
TAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAGTCTGTTGCGACTGACTCAAA
AAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAGTTTTTATATACTCCTTTAAA
ATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAAAAATAAAAACTCCCTGCCTC
TGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGGTATAACATGTTTGATGACAG
ATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTTCCAGAAAAAAAGTCAGTGTC
ATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTG
CAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCCCGAGTAGCTGGGACTACAGG
CACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCGGGCTGGTCTCAAACTCCTGA
CCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAGCATAAGCTATTTTTATCCTC
ATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGTTGCTGTAGCAAATTTGGACT
TAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGCGGGAGAATCACTTGAGTCCA
GGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGGGGTGTGCCTGTAGTCCCAGC
TACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCACCACAGAACTCAGCTTGAGT
ATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTACACTAAAATTTTCAGAAATTA
TGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTATTCTGTGTAAAGAATAGCTAT
TCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTTATATTCAACTACCAAGTTTT
GTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTATCTTGATAAATCATTTCCTCA
TCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTGGTTGTGAATCATTTGCCAGC
GAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACATTTGTGTGCACCAGAATGGA
ATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTAATTTTTAAATATTACTTTTT
ACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGTGCTTAGTGAAGCCTCCTTTT
TTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAAGTAACTGACAATATGTTTAG
CAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGCAGTGAGCTATGATGGTGCCA
CTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTAAATCAGACTTAGGGCTAGCA
AGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAACAGTTTAATTCAGTAAGTGA
GTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGATCTCACCATATTTATTTGTT
TCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATTAAGTAATAAACACCTAATAC
AGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTTTTTTCAGGAGATCACATTCT
AGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCTTGGTAGTTAAGGTTTTCTGA
GATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAGAAACTAAGTGAAACTAAGCA
GCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGGATAGGGACAGAAACACTGTG
CTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCAGATATGTATTTGAAAAGGGC
TCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGTTGTAGTAACTGAAAAATGGC
AATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATGACAACTCAGTTTTGTTGTTG
GTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCATTGAGAAAATAGTGTGGTTAG
AGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTTGTGTGCTATATTGGTTATAA
CCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTCTGTAAGTCAAAAGTCCAGGT
CTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGCCCACACTTAAGCTCCACCCT
TGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGGGAGGGAGAGGAAAGAAAACT
TTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTCTATGCATTATAGGTATATAG
TAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGATATTAAGATTTATTGAGTTT

>5699_5699_3_APP-NARG2_APP_chr21_27277335_ENST00000348990_NARG2_chr15_60728426_ENST00000261520_length(amino acids)=753AA_BP=579
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT
SIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHF
QEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQ
IRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSL
DDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGS
YLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTR

--------------------------------------------------------------
>5699_5699_4_APP-NARG2_APP_chr21_27277335_ENST00000348990_NARG2_chr15_60728426_ENST00000439632_length(transcript)=6434nt_BP=1885nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGC
CGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGAC
AAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAG
AGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAA
GAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGT
GAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGT
GATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAG
TCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAAT
GAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCA
GAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCA
GCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTAC
ATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAG
CACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTG
ATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTT
CAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCT
TTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCT
GACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGGCAT
ATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTTCAGCACTCAAGATTTCCAAT
TTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTCATGCAGCAGAAGATTCTTCA
CTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCGGCCTTCCTGGTGTACCTTCC
AGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAATACCTTGTACTTTTCCACCG
AAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATCCAGTTTCCATGGAAACCAAA
AGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAGGACTGTACCATGGAAAACTA
AATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAGGAACATTTTTCCTGTAGTAG
CTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTTTCACCCTTGAAGTTTGAGGA
GGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAACCTTTTCTAAAAATTGTAAA
TAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAGTCTGTTGCGACTGACTCAAA
AAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAGTTTTTATATACTCCTTTAAA
ATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAAAAATAAAAACTCCCTGCCTC
TGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGGTATAACATGTTTGATGACAG
ATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTTCCAGAAAAAAAGTCAGTGTC
ATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTG
CAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCCCGAGTAGCTGGGACTACAGG
CACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCGGGCTGGTCTCAAACTCCTGA
CCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAGCATAAGCTATTTTTATCCTC
ATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGTTGCTGTAGCAAATTTGGACT
TAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGCGGGAGAATCACTTGAGTCCA
GGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGGGGTGTGCCTGTAGTCCCAGC
TACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCACCACAGAACTCAGCTTGAGT
ATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTACACTAAAATTTTCAGAAATTA
TGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTATTCTGTGTAAAGAATAGCTAT
TCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTTATATTCAACTACCAAGTTTT
GTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTATCTTGATAAATCATTTCCTCA
TCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTGGTTGTGAATCATTTGCCAGC
GAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACATTTGTGTGCACCAGAATGGA
ATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTAATTTTTAAATATTACTTTTT
ACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGTGCTTAGTGAAGCCTCCTTTT
TTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAAGTAACTGACAATATGTTTAG
CAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGCAGTGAGCTATGATGGTGCCA
CTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTAAATCAGACTTAGGGCTAGCA
AGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAACAGTTTAATTCAGTAAGTGA
GTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGATCTCACCATATTTATTTGTT
TCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATTAAGTAATAAACACCTAATAC
AGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTTTTTTCAGGAGATCACATTCT
AGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCTTGGTAGTTAAGGTTTTCTGA
GATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAGAAACTAAGTGAAACTAAGCA
GCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGGATAGGGACAGAAACACTGTG
CTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCAGATATGTATTTGAAAAGGGC
TCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGTTGTAGTAACTGAAAAATGGC
AATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATGACAACTCAGTTTTGTTGTTG
GTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCATTGAGAAAATAGTGTGGTTAG
AGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTTGTGTGCTATATTGGTTATAA
CCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTCTGTAAGTCAAAAGTCCAGGT
CTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGCCCACACTTAAGCTCCACCCT
TGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGGGAGGGAGAGGAAAGAAAACT
TTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTCTATGCATTATAGGTATATAG
TAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGATATTAAGATTTATTGAGTTT

>5699_5699_4_APP-NARG2_APP_chr21_27277335_ENST00000348990_NARG2_chr15_60728426_ENST00000439632_length(amino acids)=753AA_BP=579
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT
SIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHF
QEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQ
IRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSL
DDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGS
YLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTR

--------------------------------------------------------------
>5699_5699_5_APP-NARG2_APP_chr21_27277335_ENST00000354192_NARG2_chr15_60728426_ENST00000261520_length(transcript)=6246nt_BP=1697nt
GCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTC
GCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCT
GGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCA
GTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAA
ATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAA
CTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGA
CAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAA
AGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGT
AGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGA
AGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGC
CCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCA
AGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGA
GAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGC
TCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCT
AAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGA
GCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGA
GCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGA
AACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGT
GCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGGCATATCGATGC
ATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTTCAGCACTCAAGATTTCCAATTTATTTAA
CATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTCATGCAGCAGAAGATTCTTCACTCCTGAT
TTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCGGCCTTCCTGGTGTACCTTCCAGTCTCTC
AGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAATACCTTGTACTTTTCCACCGAAATCACT
GGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATCCAGTTTCCATGGAAACCAAAAGCAGTTG
CTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAGGACTGTACCATGGAAAACTAAATTTAAA
AAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAGGAACATTTTTCCTGTAGTAGCTAGAGTG
CCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTTTCACCCTTGAAGTTTGAGGAGGATCTTG
ATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAACCTTTTCTAAAAATTGTAAATAGAAAAA
TAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAGTCTGTTGCGACTGACTCAAAAAGTTAAA
TGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAGTTTTTATATACTCCTTTAAAATGATGAA
TGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAAAAATAAAAACTCCCTGCCTCTGAAAAGT
CAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGGTATAACATGTTTGATGACAGATGCCTCT
ATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTTCCAGAAAAAAAGTCAGTGTCATTGCTCC
AGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCA
TGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCCCGAGTAGCTGGGACTACAGGCACCTACC
ACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCGGGCTGGTCTCAAACTCCTGACCTTGTGA
TCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAGCATAAGCTATTTTTATCCTCATCTATAC
TGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGTTGCTGTAGCAAATTTGGACTTAAGAAAC
TACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGCGGGAGAATCACTTGAGTCCAGGGGTTGG
AGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGGGGTGTGCCTGTAGTCCCAGCTACTCAAA
AGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCACCACAGAACTCAGCTTGAGTATCAGAGT
GTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTACACTAAAATTTTCAGAAATTATGTATGTC
ATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTATTCTGTGTAAAGAATAGCTATTCTTTTGG
CCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTTATATTCAACTACCAAGTTTTGTTTCATT
TTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTATCTTGATAAATCATTTCCTCATCCTGCCA
TTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTGGTTGTGAATCATTTGCCAGCGAGCCAAG
GGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACATTTGTGTGCACCAGAATGGAATGTGCTC
TTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTAATTTTTAAATATTACTTTTTACATCATA
AAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGTGCTTAGTGAAGCCTCCTTTTTTAACATA
CATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAAGTAACTGACAATATGTTTAGCAGGATGT
AATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGCAGTGAGCTATGATGGTGCCACTGCACTC
CATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTAAATCAGACTTAGGGCTAGCAAGGATGTG
ATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAACAGTTTAATTCAGTAAGTGAGTGCAACT
ATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGATCTCACCATATTTATTTGTTTCTTTGAT
TTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATTAAGTAATAAACACCTAATACAGTGCCTG
TCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTTTTTTCAGGAGATCACATTCTAGTGGAAG
ACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCTTGGTAGTTAAGGTTTTCTGAGATAGAAC
TTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAGAAACTAAGTGAAACTAAGCAGCCTATGA
AAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGGATAGGGACAGAAACACTGTGCTAAGACA
TTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCAGATATGTATTTGAAAAGGGCTCTTGTTG
GCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGTTGTAGTAACTGAAAAATGGCAATGGCCC
AGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATGACAACTCAGTTTTGTTGTTGGTAAGGAG
AGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCATTGAGAAAATAGTGTGGTTAGAGTGGGAA
GAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTTGTGTGCTATATTGGTTATAACCAATTTG
CTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTCTGTAAGTCAAAAGTCCAGGTCTCTCATG
AAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGCCCACACTTAAGCTCCACCCTTGAAGGGA
GAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGGGAGGGAGAGGAAAGAAAACTTTAACTTT
TCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTCTATGCATTATAGGTATATAGTAGTATTT
TGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGATATTAAGATTTATTGAGTTTCTTGTTGA

>5699_5699_5_APP-NARG2_APP_chr21_27277335_ENST00000354192_NARG2_chr15_60728426_ENST00000261520_length(amino acids)=697AA_BP=523
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE
VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAK
HRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVF
NMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMI
SEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEIT
SEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLL

--------------------------------------------------------------
>5699_5699_6_APP-NARG2_APP_chr21_27277335_ENST00000354192_NARG2_chr15_60728426_ENST00000439632_length(transcript)=6246nt_BP=1697nt
GCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTC
GCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCT
GGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCA
GTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAA
ATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAA
CTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGA
CAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAA
AGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGT
AGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGA
AGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGC
CCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCA
AGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGA
GAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGC
TCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCT
AAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGA
GCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGA
GCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGA
AACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGT
GCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGGCATATCGATGC
ATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTTCAGCACTCAAGATTTCCAATTTATTTAA
CATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTCATGCAGCAGAAGATTCTTCACTCCTGAT
TTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCGGCCTTCCTGGTGTACCTTCCAGTCTCTC
AGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAATACCTTGTACTTTTCCACCGAAATCACT
GGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATCCAGTTTCCATGGAAACCAAAAGCAGTTG
CTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAGGACTGTACCATGGAAAACTAAATTTAAA
AAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAGGAACATTTTTCCTGTAGTAGCTAGAGTG
CCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTTTCACCCTTGAAGTTTGAGGAGGATCTTG
ATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAACCTTTTCTAAAAATTGTAAATAGAAAAA
TAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAGTCTGTTGCGACTGACTCAAAAAGTTAAA
TGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAGTTTTTATATACTCCTTTAAAATGATGAA
TGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAAAAATAAAAACTCCCTGCCTCTGAAAAGT
CAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGGTATAACATGTTTGATGACAGATGCCTCT
ATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTTCCAGAAAAAAAGTCAGTGTCATTGCTCC
AGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCA
TGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCCCGAGTAGCTGGGACTACAGGCACCTACC
ACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCGGGCTGGTCTCAAACTCCTGACCTTGTGA
TCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAGCATAAGCTATTTTTATCCTCATCTATAC
TGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGTTGCTGTAGCAAATTTGGACTTAAGAAAC
TACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGCGGGAGAATCACTTGAGTCCAGGGGTTGG
AGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGGGGTGTGCCTGTAGTCCCAGCTACTCAAA
AGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCACCACAGAACTCAGCTTGAGTATCAGAGT
GTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTACACTAAAATTTTCAGAAATTATGTATGTC
ATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTATTCTGTGTAAAGAATAGCTATTCTTTTGG
CCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTTATATTCAACTACCAAGTTTTGTTTCATT
TTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTATCTTGATAAATCATTTCCTCATCCTGCCA
TTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTGGTTGTGAATCATTTGCCAGCGAGCCAAG
GGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACATTTGTGTGCACCAGAATGGAATGTGCTC
TTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTAATTTTTAAATATTACTTTTTACATCATA
AAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGTGCTTAGTGAAGCCTCCTTTTTTAACATA
CATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAAGTAACTGACAATATGTTTAGCAGGATGT
AATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGCAGTGAGCTATGATGGTGCCACTGCACTC
CATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTAAATCAGACTTAGGGCTAGCAAGGATGTG
ATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAACAGTTTAATTCAGTAAGTGAGTGCAACT
ATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGATCTCACCATATTTATTTGTTTCTTTGAT
TTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATTAAGTAATAAACACCTAATACAGTGCCTG
TCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTTTTTTCAGGAGATCACATTCTAGTGGAAG
ACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCTTGGTAGTTAAGGTTTTCTGAGATAGAAC
TTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAGAAACTAAGTGAAACTAAGCAGCCTATGA
AAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGGATAGGGACAGAAACACTGTGCTAAGACA
TTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCAGATATGTATTTGAAAAGGGCTCTTGTTG
GCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGTTGTAGTAACTGAAAAATGGCAATGGCCC
AGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATGACAACTCAGTTTTGTTGTTGGTAAGGAG
AGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCATTGAGAAAATAGTGTGGTTAGAGTGGGAA
GAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTTGTGTGCTATATTGGTTATAACCAATTTG
CTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTCTGTAAGTCAAAAGTCCAGGTCTCTCATG
AAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGCCCACACTTAAGCTCCACCCTTGAAGGGA
GAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGGGAGGGAGAGGAAAGAAAACTTTAACTTT
TCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTCTATGCATTATAGGTATATAGTAGTATTT
TGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGATATTAAGATTTATTGAGTTTCTTGTTGA

>5699_5699_6_APP-NARG2_APP_chr21_27277335_ENST00000354192_NARG2_chr15_60728426_ENST00000439632_length(amino acids)=697AA_BP=523
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE
VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAK
HRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVF
NMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMI
SEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEIT
SEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLL

--------------------------------------------------------------
>5699_5699_7_APP-NARG2_APP_chr21_27277335_ENST00000357903_NARG2_chr15_60728426_ENST00000261520_length(transcript)=6622nt_BP=2073nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCC
AGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTG
ATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCA
AAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTG
TGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACA
CAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATG
ACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCA
CCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCT
CCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAG
AGTACTGCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGG
ATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGG
AAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAAC
AGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGG
AGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGG
ACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACC
TCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATG
AGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCA
TGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTT
TTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGAC
CAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTTCAGCACTCAAGA
TTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTCATGCAGCAGAAG
ATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCGGCCTTCCTGGTG
TACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAATACCTTGTACTT
TTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATCCAGTTTCCATGG
AAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAGGACTGTACCATG
GAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAGGAACATTTTTCC
TGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTTTCACCCTTGAAG
TTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAACCTTTTCTAAAA
ATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAGTCTGTTGCGACT
GACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAGTTTTTATATACT
CCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAAAAATAAAAACTC
CCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGGTATAACATGTTT
GATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTTCCAGAAAAAAAG
TCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGG
CTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCCCGAGTAGCTGGG
ACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCGGGCTGGTCTCAA
ACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAGCATAAGCTATTT
TTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGTTGCTGTAGCAAA
TTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGCGGGAGAATCACT
TGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGGGGTGTGCCTGTA
GTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCACCACAGAACTCA
GCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTACACTAAAATTTTC
AGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTATTCTGTGTAAAGA
ATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTTATATTCAACTAC
CAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTATCTTGATAAATCA
TTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTGGTTGTGAATCAT
TTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACATTTGTGTGCACC
AGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTAATTTTTAAATAT
TACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGTGCTTAGTGAAGC
CTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAAGTAACTGACAAT
ATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGCAGTGAGCTATGA
TGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTAAATCAGACTTAG
GGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAACAGTTTAATTCA
GTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGATCTCACCATATT
TATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATTAAGTAATAAACA
CCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTTTTTTCAGGAGAT
CACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCTTGGTAGTTAAGG
TTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAGAAACTAAGTGAA
ACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGGATAGGGACAGAA
ACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCAGATATGTATTTG
AAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGTTGTAGTAACTGA
AAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATGACAACTCAGTTT
TGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCATTGAGAAAATAGT
GTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTTGTGTGCTATATT
GGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTCTGTAAGTCAAAA
GTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGCCCACACTTAAGC
TCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGGGAGGGAGAGGAA
AGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTCTATGCATTATAG
GTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGATATTAAGATTTA

>5699_5699_7_APP-NARG2_APP_chr21_27277335_ENST00000357903_NARG2_chr15_60728426_ENST00000261520_length(amino acids)=809AA_BP=635
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT
SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYL
ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRR
RLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQ
DEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRG
LTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHC

--------------------------------------------------------------
>5699_5699_8_APP-NARG2_APP_chr21_27277335_ENST00000357903_NARG2_chr15_60728426_ENST00000439632_length(transcript)=6622nt_BP=2073nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCC
AGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTG
ATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCA
AAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTG
TGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACA
CAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATG
ACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCA
CCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCT
CCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAG
AGTACTGCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGG
ATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGG
AAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAAC
AGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGG
AGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGG
ACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACC
TCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATG
AGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCA
TGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTT
TTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGAC
CAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTTCAGCACTCAAGA
TTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTCATGCAGCAGAAG
ATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCGGCCTTCCTGGTG
TACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAATACCTTGTACTT
TTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATCCAGTTTCCATGG
AAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAGGACTGTACCATG
GAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAGGAACATTTTTCC
TGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTTTCACCCTTGAAG
TTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAACCTTTTCTAAAA
ATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAGTCTGTTGCGACT
GACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAGTTTTTATATACT
CCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAAAAATAAAAACTC
CCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGGTATAACATGTTT
GATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTTCCAGAAAAAAAG
TCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGG
CTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCCCGAGTAGCTGGG
ACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCGGGCTGGTCTCAA
ACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAGCATAAGCTATTT
TTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGTTGCTGTAGCAAA
TTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGCGGGAGAATCACT
TGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGGGGTGTGCCTGTA
GTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCACCACAGAACTCA
GCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTACACTAAAATTTTC
AGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTATTCTGTGTAAAGA
ATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTTATATTCAACTAC
CAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTATCTTGATAAATCA
TTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTGGTTGTGAATCAT
TTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACATTTGTGTGCACC
AGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTAATTTTTAAATAT
TACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGTGCTTAGTGAAGC
CTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAAGTAACTGACAAT
ATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGCAGTGAGCTATGA
TGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTAAATCAGACTTAG
GGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAACAGTTTAATTCA
GTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGATCTCACCATATT
TATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATTAAGTAATAAACA
CCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTTTTTTCAGGAGAT
CACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCTTGGTAGTTAAGG
TTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAGAAACTAAGTGAA
ACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGGATAGGGACAGAA
ACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCAGATATGTATTTG
AAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGTTGTAGTAACTGA
AAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATGACAACTCAGTTT
TGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCATTGAGAAAATAGT
GTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTTGTGTGCTATATT
GGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTCTGTAAGTCAAAA
GTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGCCCACACTTAAGC
TCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGGGAGGGAGAGGAA
AGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTCTATGCATTATAG
GTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGATATTAAGATTTA

>5699_5699_8_APP-NARG2_APP_chr21_27277335_ENST00000357903_NARG2_chr15_60728426_ENST00000439632_length(amino acids)=809AA_BP=635
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT
SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYL
ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRR
RLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQ
DEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRG
LTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHC

--------------------------------------------------------------
>5699_5699_9_APP-NARG2_APP_chr21_27277335_ENST00000359726_NARG2_chr15_60728426_ENST00000261520_length(transcript)=6544nt_BP=1995nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA
ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC
CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT
GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT
GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG
ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG
TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAG
AAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTGTCCCAAAGTTTAC
TCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCG
AGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCA
TGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGG
AATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCC
GCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCG
CAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGG
TTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGG
ATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAA
ACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGC
CGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGAC
TGACCACTCGACCAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTT
CAGCACTCAAGATTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTC
ATGCAGCAGAAGATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCG
GCCTTCCTGGTGTACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAA
TACCTTGTACTTTTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATC
CAGTTTCCATGGAAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAG
GACTGTACCATGGAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAG
GAACATTTTTCCTGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTT
TCACCCTTGAAGTTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAA
CCTTTTCTAAAAATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAG
TCTGTTGCGACTGACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAG
TTTTTATATACTCCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAA
AAATAAAAACTCCCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGG
TATAACATGTTTGATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTT
CCAGAAAAAAAGTCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCT
CTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCC
CGAGTAGCTGGGACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCG
GGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAG
CATAAGCTATTTTTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGT
TGCTGTAGCAAATTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGC
GGGAGAATCACTTGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGG
GGTGTGCCTGTAGTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCA
CCACAGAACTCAGCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTAC
ACTAAAATTTTCAGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTAT
TCTGTGTAAAGAATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTT
ATATTCAACTACCAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTAT
CTTGATAAATCATTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTG
GTTGTGAATCATTTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACA
TTTGTGTGCACCAGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTA
ATTTTTAAATATTACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGT
GCTTAGTGAAGCCTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAA
GTAACTGACAATATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGC
AGTGAGCTATGATGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTA
AATCAGACTTAGGGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAA
CAGTTTAATTCAGTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGA
TCTCACCATATTTATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATT
AAGTAATAAACACCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTT
TTTTCAGGAGATCACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCT
TGGTAGTTAAGGTTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAG
AAACTAAGTGAAACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGG
ATAGGGACAGAAACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCA
GATATGTATTTGAAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGT
TGTAGTAACTGAAAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATG
ACAACTCAGTTTTGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCAT
TGAGAAAATAGTGTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTT
GTGTGCTATATTGGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTC
TGTAAGTCAAAAGTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGC
CCACACTTAAGCTCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGG
GAGGGAGAGGAAAGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTC
TATGCATTATAGGTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGA

>5699_5699_9_APP-NARG2_APP_chr21_27277335_ENST00000359726_NARG2_chr15_60728426_ENST00000261520_length(amino acids)=772AA_BP=598
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT
SIATTTTTTTESVEEVVRVSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA
ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQ
HTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS
LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISN
LFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPP

--------------------------------------------------------------
>5699_5699_10_APP-NARG2_APP_chr21_27277335_ENST00000359726_NARG2_chr15_60728426_ENST00000439632_length(transcript)=6544nt_BP=1995nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA
ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC
CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT
GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT
GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG
ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG
TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAG
AAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTGTCCCAAAGTTTAC
TCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCG
AGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCA
TGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGG
AATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCC
GCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCG
CAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGG
TTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGG
ATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAA
ACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGC
CGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGAC
TGACCACTCGACCAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTT
CAGCACTCAAGATTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTC
ATGCAGCAGAAGATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCG
GCCTTCCTGGTGTACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAA
TACCTTGTACTTTTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATC
CAGTTTCCATGGAAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAG
GACTGTACCATGGAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAG
GAACATTTTTCCTGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTT
TCACCCTTGAAGTTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAA
CCTTTTCTAAAAATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAG
TCTGTTGCGACTGACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAG
TTTTTATATACTCCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAA
AAATAAAAACTCCCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGG
TATAACATGTTTGATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTT
CCAGAAAAAAAGTCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCT
CTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCC
CGAGTAGCTGGGACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCG
GGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAG
CATAAGCTATTTTTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGT
TGCTGTAGCAAATTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGC
GGGAGAATCACTTGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGG
GGTGTGCCTGTAGTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCA
CCACAGAACTCAGCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTAC
ACTAAAATTTTCAGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTAT
TCTGTGTAAAGAATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTT
ATATTCAACTACCAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTAT
CTTGATAAATCATTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTG
GTTGTGAATCATTTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACA
TTTGTGTGCACCAGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTA
ATTTTTAAATATTACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGT
GCTTAGTGAAGCCTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAA
GTAACTGACAATATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGC
AGTGAGCTATGATGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTA
AATCAGACTTAGGGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAA
CAGTTTAATTCAGTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGA
TCTCACCATATTTATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATT
AAGTAATAAACACCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTT
TTTTCAGGAGATCACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCT
TGGTAGTTAAGGTTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAG
AAACTAAGTGAAACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGG
ATAGGGACAGAAACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCA
GATATGTATTTGAAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGT
TGTAGTAACTGAAAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATG
ACAACTCAGTTTTGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCAT
TGAGAAAATAGTGTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTT
GTGTGCTATATTGGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTC
TGTAAGTCAAAAGTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGC
CCACACTTAAGCTCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGG
GAGGGAGAGGAAAGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTC
TATGCATTATAGGTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGA

>5699_5699_10_APP-NARG2_APP_chr21_27277335_ENST00000359726_NARG2_chr15_60728426_ENST00000439632_length(amino acids)=772AA_BP=598
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT
SIATTTTTTTESVEEVVRVSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA
ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQ
HTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS
LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISN
LFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPP

--------------------------------------------------------------
>5699_5699_11_APP-NARG2_APP_chr21_27277335_ENST00000439274_NARG2_chr15_60728426_ENST00000261520_length(transcript)=6378nt_BP=1829nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTG
CAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATT
CTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTT
GCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAA
TGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGT
AGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGA
GGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGA
GGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAA
GTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCAT
GTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGT
TGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAG
AATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTT
CCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCT
CAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAA
GAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCA
GATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGC
CGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAG
GATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCT
GGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGC
TGCCGACCGAGGACTGACCACTCGACCAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATT
AAAAGAAAAGCTTTCAGCACTCAAGATTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTC
CTACTTGTTATCTCATGCAGCAGAAGATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTA
TAAAACACATTGCGGCCTTCCTGGTGTACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATAT
CCATCATGGAAGAATACCTTGTACTTTTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACG
CAGCCACAGGAATCCAGTTTCCATGGAAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAG
AAAAATAACTTGAGGACTGTACCATGGAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAA
TCAGTAGGCAAGAGGAACATTTTTCCTGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATG
GAATGGTATGCTTTTCACCCTTGAAGTTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAAT
ATTTTTACATTAAACCTTTTCTAAAAATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTT
AGTTATATTGCCAGTCTGTTGCGACTGACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTG
ACCCATTTTGACAGTTTTTATATACTCCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCC
ATTACAGAAGCCAAAAATAAAAACTCCCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAG
AAAAAATTTGGTGGTATAACATGTTTGATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGA
GATAGGTATGTTTTCCAGAAAAAAAGTCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGA
GATGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTC
CTGCCTCATCCTCCCGAGTAGCTGGGACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGT
TACCATGTTGGCCGGGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCA
CCGTGCCTGGCCAGCATAAGCTATTTTTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCA
TAATCAACTGATGTTGCTGTAGCAAATTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTT
CGCAAGGCCGAGGCGGGAGAATCACTTGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTA
GCCGGGTGTGGTGGGGTGTGCCTGTAGTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGT
GAGTTGTGATCGCACCACAGAACTCAGCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATC
TTTAGAACCCTTACACTAAAATTTTCAGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGA
AATTTTTTAGCTATTCTGTGTAAAGAATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAAC
AGTTGAAAATACTTATATTCAACTACCAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTAT
TAGTAAAATTGTATCTTGATAAATCATTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATC
CCAGAAATGTTTTGGTTGTGAATCATTTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTT
ATTTTTAATGTACATTTGTGTGCACCAGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAA
AGACTTGCCTTTTAATTTTTAAATATTACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGT
AGTTTTTTGCTTGTGCTTAGTGAAGCCTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAAT
TTATAAGCCAAGAAGTAACTGACAATATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAG
GAGTTTGAGGCTGCAGTGAGCTATGATGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTT
TTTTTTTTTTTTTAAATCAGACTTAGGGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACA
CACCTCTTTGAAAACAGTTTAATTCAGTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGC
CTTGTTTTTTCAGATCTCACCATATTTATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTG
TTTTGTTCACCATTAAGTAATAAACACCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGT
ATCAAAGATTTTTTTTTTCAGGAGATCACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTC
ATCTAACCAGATCTTGGTAGTTAAGGTTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAA
GGTCTTCCACAAAGAAACTAAGTGAAACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGA
GAGAAAACTGCAGGATAGGGACAGAAACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATT
AACTGACATGATCAGATATGTATTTGAAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATG
TTGGGAGCCTGTGTTGTAGTAACTGAAAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGA
AAAAAAAAAAAATGACAACTCAGTTTTGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGA
TGGTGTTAACCCATTGAGAAAATAGTGTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTT
TGGATTCTAGGTTTGTGTGCTATATTGGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACAT
TATCTCACAGTTTCTGTAAGTCAAAAGTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTA
GTAAGTCGCTAAGCCCACACTTAAGCTCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTAT
GAACAGGTTTAGGGGAGGGAGAGGAAAGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGAT
GTTAAGACGTTTTCTATGCATTATAGGTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAAC

>5699_5699_11_APP-NARG2_APP_chr21_27277335_ENST00000439274_NARG2_chr15_60728426_ENST00000261520_length(amino acids)=772AA_BP=598
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE
VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGG
NRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA
ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQ
HTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS
LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISN
LFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPP

--------------------------------------------------------------
>5699_5699_12_APP-NARG2_APP_chr21_27277335_ENST00000439274_NARG2_chr15_60728426_ENST00000439632_length(transcript)=6378nt_BP=1829nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTG
CAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATT
CTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTT
GCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAA
TGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGT
AGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGA
GGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGA
GGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAA
GTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCAT
GTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGT
TGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAG
AATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTT
CCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCT
CAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAA
GAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCA
GATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGC
CGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAG
GATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCT
GGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGC
TGCCGACCGAGGACTGACCACTCGACCAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATT
AAAAGAAAAGCTTTCAGCACTCAAGATTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTC
CTACTTGTTATCTCATGCAGCAGAAGATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTA
TAAAACACATTGCGGCCTTCCTGGTGTACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATAT
CCATCATGGAAGAATACCTTGTACTTTTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACG
CAGCCACAGGAATCCAGTTTCCATGGAAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAG
AAAAATAACTTGAGGACTGTACCATGGAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAA
TCAGTAGGCAAGAGGAACATTTTTCCTGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATG
GAATGGTATGCTTTTCACCCTTGAAGTTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAAT
ATTTTTACATTAAACCTTTTCTAAAAATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTT
AGTTATATTGCCAGTCTGTTGCGACTGACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTG
ACCCATTTTGACAGTTTTTATATACTCCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCC
ATTACAGAAGCCAAAAATAAAAACTCCCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAG
AAAAAATTTGGTGGTATAACATGTTTGATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGA
GATAGGTATGTTTTCCAGAAAAAAAGTCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGA
GATGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTC
CTGCCTCATCCTCCCGAGTAGCTGGGACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGT
TACCATGTTGGCCGGGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCA
CCGTGCCTGGCCAGCATAAGCTATTTTTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCA
TAATCAACTGATGTTGCTGTAGCAAATTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTT
CGCAAGGCCGAGGCGGGAGAATCACTTGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTA
GCCGGGTGTGGTGGGGTGTGCCTGTAGTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGT
GAGTTGTGATCGCACCACAGAACTCAGCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATC
TTTAGAACCCTTACACTAAAATTTTCAGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGA
AATTTTTTAGCTATTCTGTGTAAAGAATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAAC
AGTTGAAAATACTTATATTCAACTACCAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTAT
TAGTAAAATTGTATCTTGATAAATCATTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATC
CCAGAAATGTTTTGGTTGTGAATCATTTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTT
ATTTTTAATGTACATTTGTGTGCACCAGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAA
AGACTTGCCTTTTAATTTTTAAATATTACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGT
AGTTTTTTGCTTGTGCTTAGTGAAGCCTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAAT
TTATAAGCCAAGAAGTAACTGACAATATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAG
GAGTTTGAGGCTGCAGTGAGCTATGATGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTT
TTTTTTTTTTTTTAAATCAGACTTAGGGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACA
CACCTCTTTGAAAACAGTTTAATTCAGTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGC
CTTGTTTTTTCAGATCTCACCATATTTATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTG
TTTTGTTCACCATTAAGTAATAAACACCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGT
ATCAAAGATTTTTTTTTTCAGGAGATCACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTC
ATCTAACCAGATCTTGGTAGTTAAGGTTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAA
GGTCTTCCACAAAGAAACTAAGTGAAACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGA
GAGAAAACTGCAGGATAGGGACAGAAACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATT
AACTGACATGATCAGATATGTATTTGAAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATG
TTGGGAGCCTGTGTTGTAGTAACTGAAAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGA
AAAAAAAAAAAATGACAACTCAGTTTTGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGA
TGGTGTTAACCCATTGAGAAAATAGTGTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTT
TGGATTCTAGGTTTGTGTGCTATATTGGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACAT
TATCTCACAGTTTCTGTAAGTCAAAAGTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTA
GTAAGTCGCTAAGCCCACACTTAAGCTCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTAT
GAACAGGTTTAGGGGAGGGAGAGGAAAGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGAT
GTTAAGACGTTTTCTATGCATTATAGGTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAAC

>5699_5699_12_APP-NARG2_APP_chr21_27277335_ENST00000439274_NARG2_chr15_60728426_ENST00000439632_length(amino acids)=772AA_BP=598
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE
VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGG
NRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA
ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQ
HTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS
LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISN
LFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPP

--------------------------------------------------------------
>5699_5699_13_APP-NARG2_APP_chr21_27277335_ENST00000440126_NARG2_chr15_60728426_ENST00000261520_length(transcript)=6706nt_BP=2157nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACT
GGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCC
TTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGA
CATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTT
GCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACT
ATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGG
ACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCA
CCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCT
GGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACT
GCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGA
ATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGG
CAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAG
CAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACT
ACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGAC
AGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTG
TGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGC
TTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCAT
CTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGG
CTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGGC
ATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTTCAGCACTCAAGATTTCCA
ATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTCATGCAGCAGAAGATTCTT
CACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCGGCCTTCCTGGTGTACCTT
CCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAATACCTTGTACTTTTCCAC
CGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATCCAGTTTCCATGGAAACCA
AAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAGGACTGTACCATGGAAAAC
TAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAGGAACATTTTTCCTGTAGT
AGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTTTCACCCTTGAAGTTTGAG
GAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAACCTTTTCTAAAAATTGTA
AATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAGTCTGTTGCGACTGACTCA
AAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAGTTTTTATATACTCCTTTA
AAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAAAAATAAAAACTCCCTGCC
TCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGGTATAACATGTTTGATGAC
AGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTTCCAGAAAAAAAGTCAGTG
TCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAG
TGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCCCGAGTAGCTGGGACTACA
GGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCGGGCTGGTCTCAAACTCCT
GACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAGCATAAGCTATTTTTATCC
TCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGTTGCTGTAGCAAATTTGGA
CTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGCGGGAGAATCACTTGAGTC
CAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGGGGTGTGCCTGTAGTCCCA
GCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCACCACAGAACTCAGCTTGA
GTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTACACTAAAATTTTCAGAAAT
TATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTATTCTGTGTAAAGAATAGCT
ATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTTATATTCAACTACCAAGTT
TTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTATCTTGATAAATCATTTCCT
CATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTGGTTGTGAATCATTTGCCA
GCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACATTTGTGTGCACCAGAATG
GAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTAATTTTTAAATATTACTTT
TTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGTGCTTAGTGAAGCCTCCTT
TTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAAGTAACTGACAATATGTTT
AGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGCAGTGAGCTATGATGGTGC
CACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTAAATCAGACTTAGGGCTAG
CAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAACAGTTTAATTCAGTAAGT
GAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGATCTCACCATATTTATTTG
TTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATTAAGTAATAAACACCTAAT
ACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTTTTTTCAGGAGATCACATT
CTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCTTGGTAGTTAAGGTTTTCT
GAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAGAAACTAAGTGAAACTAAG
CAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGGATAGGGACAGAAACACTG
TGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCAGATATGTATTTGAAAAGG
GCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGTTGTAGTAACTGAAAAATG
GCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATGACAACTCAGTTTTGTTGT
TGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCATTGAGAAAATAGTGTGGTT
AGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTTGTGTGCTATATTGGTTAT
AACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTCTGTAAGTCAAAAGTCCAG
GTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGCCCACACTTAAGCTCCACC
CTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGGGAGGGAGAGGAAAGAAAA
CTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTCTATGCATTATAGGTATAT
AGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGATATTAAGATTTATTGAGT

>5699_5699_13_APP-NARG2_APP_chr21_27277335_ENST00000440126_NARG2_chr15_60728426_ENST00000261520_length(amino acids)=813AA_BP=639
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVV
EANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI
DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEAT
ERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAV
DKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAML
NDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVA
EEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPA
ADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLY
KTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCLPAQQVETEGVAPHKR

--------------------------------------------------------------
>5699_5699_14_APP-NARG2_APP_chr21_27277335_ENST00000440126_NARG2_chr15_60728426_ENST00000439632_length(transcript)=6706nt_BP=2157nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACT
GGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCC
TTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGA
CATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTT
GCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACT
ATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGG
ACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCA
CCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCT
GGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACT
GCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGA
ATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGG
CAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAG
CAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACT
ACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGAC
AGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTG
TGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGC
TTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCAT
CTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGG
CTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGGC
ATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTTCAGCACTCAAGATTTCCA
ATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTCATGCAGCAGAAGATTCTT
CACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCGGCCTTCCTGGTGTACCTT
CCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAATACCTTGTACTTTTCCAC
CGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATCCAGTTTCCATGGAAACCA
AAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAGGACTGTACCATGGAAAAC
TAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAGGAACATTTTTCCTGTAGT
AGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTTTCACCCTTGAAGTTTGAG
GAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAACCTTTTCTAAAAATTGTA
AATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAGTCTGTTGCGACTGACTCA
AAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAGTTTTTATATACTCCTTTA
AAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAAAAATAAAAACTCCCTGCC
TCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGGTATAACATGTTTGATGAC
AGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTTCCAGAAAAAAAGTCAGTG
TCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAG
TGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCCCGAGTAGCTGGGACTACA
GGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCGGGCTGGTCTCAAACTCCT
GACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAGCATAAGCTATTTTTATCC
TCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGTTGCTGTAGCAAATTTGGA
CTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGCGGGAGAATCACTTGAGTC
CAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGGGGTGTGCCTGTAGTCCCA
GCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCACCACAGAACTCAGCTTGA
GTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTACACTAAAATTTTCAGAAAT
TATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTATTCTGTGTAAAGAATAGCT
ATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTTATATTCAACTACCAAGTT
TTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTATCTTGATAAATCATTTCCT
CATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTGGTTGTGAATCATTTGCCA
GCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACATTTGTGTGCACCAGAATG
GAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTAATTTTTAAATATTACTTT
TTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGTGCTTAGTGAAGCCTCCTT
TTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAAGTAACTGACAATATGTTT
AGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGCAGTGAGCTATGATGGTGC
CACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTAAATCAGACTTAGGGCTAG
CAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAACAGTTTAATTCAGTAAGT
GAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGATCTCACCATATTTATTTG
TTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATTAAGTAATAAACACCTAAT
ACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTTTTTTCAGGAGATCACATT
CTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCTTGGTAGTTAAGGTTTTCT
GAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAGAAACTAAGTGAAACTAAG
CAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGGATAGGGACAGAAACACTG
TGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCAGATATGTATTTGAAAAGG
GCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGTTGTAGTAACTGAAAAATG
GCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATGACAACTCAGTTTTGTTGT
TGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCATTGAGAAAATAGTGTGGTT
AGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTTGTGTGCTATATTGGTTAT
AACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTCTGTAAGTCAAAAGTCCAG
GTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGCCCACACTTAAGCTCCACC
CTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGGGAGGGAGAGGAAAGAAAA
CTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTCTATGCATTATAGGTATAT
AGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGATATTAAGATTTATTGAGT

>5699_5699_14_APP-NARG2_APP_chr21_27277335_ENST00000440126_NARG2_chr15_60728426_ENST00000439632_length(amino acids)=813AA_BP=639
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVV
EANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI
DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEAT
ERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAV
DKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAML
NDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVA
EEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPA
ADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLY
KTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCLPAQQVETEGVAPHKR

--------------------------------------------------------------
>5699_5699_15_APP-NARG2_APP_chr21_27277335_ENST00000448388_NARG2_chr15_60728426_ENST00000261520_length(transcript)=6374nt_BP=1825nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCA
GTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAG
TTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCAC
ACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGG
GTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGC
GGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAA
GCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGC
ATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGAC
AAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATG
TCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAG
GAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAAT
GACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAG
TATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATC
CGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAG
GAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATC
AGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGAC
GATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCC
GACCGAGGACTGACCACTCGACCAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAA
GAAAAGCTTTCAGCACTCAAGATTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTAC
TTGTTATCTCATGCAGCAGAAGATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAA
ACACATTGCGGCCTTCCTGGTGTACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCAT
CATGGAAGAATACCTTGTACTTTTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGC
CACAGGAATCCAGTTTCCATGGAAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAA
ATAACTTGAGGACTGTACCATGGAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAG
TAGGCAAGAGGAACATTTTTCCTGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAAT
GGTATGCTTTTCACCCTTGAAGTTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTT
TTACATTAAACCTTTTCTAAAAATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTT
ATATTGCCAGTCTGTTGCGACTGACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCC
ATTTTGACAGTTTTTATATACTCCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTA
CAGAAGCCAAAAATAAAAACTCCCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAA
AATTTGGTGGTATAACATGTTTGATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATA
GGTATGTTTTCCAGAAAAAAAGTCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATG
GAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGC
CTCATCCTCCCGAGTAGCTGGGACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACC
ATGTTGGCCGGGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGT
GCCTGGCCAGCATAAGCTATTTTTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAAT
CAACTGATGTTGCTGTAGCAAATTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCA
AGGCCGAGGCGGGAGAATCACTTGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCG
GGTGTGGTGGGGTGTGCCTGTAGTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGT
TGTGATCGCACCACAGAACTCAGCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTA
GAACCCTTACACTAAAATTTTCAGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATT
TTTTAGCTATTCTGTGTAAAGAATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTT
GAAAATACTTATATTCAACTACCAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGT
AAAATTGTATCTTGATAAATCATTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAG
AAATGTTTTGGTTGTGAATCATTTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTT
TTAATGTACATTTGTGTGCACCAGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGAC
TTGCCTTTTAATTTTTAAATATTACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTT
TTTTGCTTGTGCTTAGTGAAGCCTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTAT
AAGCCAAGAAGTAACTGACAATATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGT
TTGAGGCTGCAGTGAGCTATGATGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTT
TTTTTTTTTAAATCAGACTTAGGGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACC
TCTTTGAAAACAGTTTAATTCAGTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTG
TTTTTTCAGATCTCACCATATTTATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTT
GTTCACCATTAAGTAATAAACACCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCA
AAGATTTTTTTTTTCAGGAGATCACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCT
AACCAGATCTTGGTAGTTAAGGTTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTC
TTCCACAAAGAAACTAAGTGAAACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGA
AAACTGCAGGATAGGGACAGAAACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACT
GACATGATCAGATATGTATTTGAAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGG
GAGCCTGTGTTGTAGTAACTGAAAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAA
AAAAAAAATGACAACTCAGTTTTGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGT
GTTAACCCATTGAGAAAATAGTGTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGA
TTCTAGGTTTGTGTGCTATATTGGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATC
TCACAGTTTCTGTAAGTCAAAAGTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAA
GTCGCTAAGCCCACACTTAAGCTCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAAC
AGGTTTAGGGGAGGGAGAGGAAAGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTA
AGACGTTTTCTATGCATTATAGGTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTA

>5699_5699_15_APP-NARG2_APP_chr21_27277335_ENST00000448388_NARG2_chr15_60728426_ENST00000261520_length(amino acids)=726AA_BP=552
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRC
LVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSD
VWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTP
DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVE
AMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP
AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDA
RPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAY
NLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCLPAQQVETEGVAP

--------------------------------------------------------------
>5699_5699_16_APP-NARG2_APP_chr21_27277335_ENST00000448388_NARG2_chr15_60728426_ENST00000439632_length(transcript)=6374nt_BP=1825nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCA
GTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAG
TTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCAC
ACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGG
GTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGC
GGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAA
GCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGC
ATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGAC
AAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATG
TCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAG
GAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAAT
GACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAG
TATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATC
CGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAG
GAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATC
AGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGAC
GATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCC
GACCGAGGACTGACCACTCGACCAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAA
GAAAAGCTTTCAGCACTCAAGATTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTAC
TTGTTATCTCATGCAGCAGAAGATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAA
ACACATTGCGGCCTTCCTGGTGTACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCAT
CATGGAAGAATACCTTGTACTTTTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGC
CACAGGAATCCAGTTTCCATGGAAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAA
ATAACTTGAGGACTGTACCATGGAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAG
TAGGCAAGAGGAACATTTTTCCTGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAAT
GGTATGCTTTTCACCCTTGAAGTTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTT
TTACATTAAACCTTTTCTAAAAATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTT
ATATTGCCAGTCTGTTGCGACTGACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCC
ATTTTGACAGTTTTTATATACTCCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTA
CAGAAGCCAAAAATAAAAACTCCCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAA
AATTTGGTGGTATAACATGTTTGATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATA
GGTATGTTTTCCAGAAAAAAAGTCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATG
GAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGC
CTCATCCTCCCGAGTAGCTGGGACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACC
ATGTTGGCCGGGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGT
GCCTGGCCAGCATAAGCTATTTTTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAAT
CAACTGATGTTGCTGTAGCAAATTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCA
AGGCCGAGGCGGGAGAATCACTTGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCG
GGTGTGGTGGGGTGTGCCTGTAGTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGT
TGTGATCGCACCACAGAACTCAGCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTA
GAACCCTTACACTAAAATTTTCAGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATT
TTTTAGCTATTCTGTGTAAAGAATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTT
GAAAATACTTATATTCAACTACCAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGT
AAAATTGTATCTTGATAAATCATTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAG
AAATGTTTTGGTTGTGAATCATTTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTT
TTAATGTACATTTGTGTGCACCAGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGAC
TTGCCTTTTAATTTTTAAATATTACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTT
TTTTGCTTGTGCTTAGTGAAGCCTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTAT
AAGCCAAGAAGTAACTGACAATATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGT
TTGAGGCTGCAGTGAGCTATGATGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTT
TTTTTTTTTAAATCAGACTTAGGGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACC
TCTTTGAAAACAGTTTAATTCAGTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTG
TTTTTTCAGATCTCACCATATTTATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTT
GTTCACCATTAAGTAATAAACACCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCA
AAGATTTTTTTTTTCAGGAGATCACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCT
AACCAGATCTTGGTAGTTAAGGTTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTC
TTCCACAAAGAAACTAAGTGAAACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGA
AAACTGCAGGATAGGGACAGAAACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACT
GACATGATCAGATATGTATTTGAAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGG
GAGCCTGTGTTGTAGTAACTGAAAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAA
AAAAAAAATGACAACTCAGTTTTGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGT
GTTAACCCATTGAGAAAATAGTGTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGA
TTCTAGGTTTGTGTGCTATATTGGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATC
TCACAGTTTCTGTAAGTCAAAAGTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAA
GTCGCTAAGCCCACACTTAAGCTCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAAC
AGGTTTAGGGGAGGGAGAGGAAAGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTA
AGACGTTTTCTATGCATTATAGGTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTA

>5699_5699_16_APP-NARG2_APP_chr21_27277335_ENST00000448388_NARG2_chr15_60728426_ENST00000439632_length(amino acids)=726AA_BP=552
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRC
LVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSD
VWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTP
DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVE
AMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP
AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDA
RPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAY
NLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCLPAQQVETEGVAP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for APP-NARG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-1518732_751654.3333333333334771.0G(o)-alpha
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-1316732_751579.3333333333334696.0G(o)-alpha
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-1215732_751523.3333333333334640.0G(o)-alpha
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-1417732_751635.3333333333334752.0G(o)-alpha
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-117732_7510753.0G(o)-alpha
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-1417732_751598.3333333333334715.0G(o)-alpha
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-1417732_751630.3333333333334747.0G(o)-alpha
HgeneAPPchr21:27277335chr15:60728426ENST00000346798-1518695_722654.3333333333334771.0PSEN1
HgeneAPPchr21:27277335chr15:60728426ENST00000348990-1316695_722579.3333333333334696.0PSEN1
HgeneAPPchr21:27277335chr15:60728426ENST00000354192-1215695_722523.3333333333334640.0PSEN1
HgeneAPPchr21:27277335chr15:60728426ENST00000357903-1417695_722635.3333333333334752.0PSEN1
HgeneAPPchr21:27277335chr15:60728426ENST00000358918-117695_7220753.0PSEN1
HgeneAPPchr21:27277335chr15:60728426ENST00000359726-1417695_722598.3333333333334715.0PSEN1
HgeneAPPchr21:27277335chr15:60728426ENST00000440126-1417695_722630.3333333333334747.0PSEN1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for APP-NARG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for APP-NARG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPPC0002395Alzheimer's Disease63CTD_human;UNIPROT
HgeneAPPC0011265Presenile dementia35CTD_human
HgeneAPPC0276496Familial Alzheimer Disease (FAD)35CTD_human
HgeneAPPC0494463Alzheimer Disease, Late Onset35CTD_human
HgeneAPPC0546126Acute Confusional Senile Dementia35CTD_human
HgeneAPPC0750900Alzheimer's Disease, Focal Onset35CTD_human
HgeneAPPC0750901Alzheimer Disease, Early Onset35CTD_human
HgeneAPPC0025261Memory Disorders16CTD_human
HgeneAPPC0233794Memory impairment16CTD_human
HgeneAPPC0751292Age-Related Memory Disorders16CTD_human
HgeneAPPC0751293Memory Disorder, Semantic16CTD_human
HgeneAPPC0751294Memory Disorder, Spatial16CTD_human
HgeneAPPC0751295Memory Loss16CTD_human
HgeneAPPC0027746Nerve Degeneration11CTD_human
HgeneAPPC0023186Learning Disorders8CTD_human
HgeneAPPC0751262Adult Learning Disorders8CTD_human
HgeneAPPC0751263Learning Disturbance8CTD_human
HgeneAPPC0751265Learning Disabilities8CTD_human
HgeneAPPC1330966Developmental Academic Disorder8CTD_human
HgeneAPPC2751536CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED7CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneAPPC0009241Cognition Disorders5CTD_human
HgeneAPPC0011570Mental Depression5PSYGENET
HgeneAPPC0011581Depressive disorder5PSYGENET
HgeneAPPC0234544Todd Paralysis5CTD_human
HgeneAPPC0522224Paralysed5CTD_human
HgeneAPPC0497327Dementia3CTD_human;GENOMICS_ENGLAND
HgeneAPPC2931672Cerebral hemorrhage with amyloidosis, hereditary, Dutch type3CTD_human;ORPHANET
HgeneAPPC0270715Degenerative Diseases, Central Nervous System2CTD_human
HgeneAPPC0333463Senile Plaques2CTD_human
HgeneAPPC0524851Neurodegenerative Disorders2CTD_human
HgeneAPPC0600467Neurogenic Inflammation2CTD_human
HgeneAPPC0751733Degenerative Diseases, Spinal Cord2CTD_human
HgeneAPPC2751494CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ARCTIC VARIANT2CTD_human
HgeneAPPC2936349Plaque, Amyloid2CTD_human
HgeneAPPC3888307CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, FLEMISH VARIANT2CTD_human
HgeneAPPC3888308CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ITALIAN VARIANT2CTD_human
HgeneAPPC3888309CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, IOWA VARIANT2CTD_human
HgeneAPPC0002622Amnesia1CTD_human
HgeneAPPC0002726Amyloidosis1CTD_human
HgeneAPPC0003469Anxiety Disorders1CTD_human
HgeneAPPC0005586Bipolar Disorder1PSYGENET
HgeneAPPC0006111Brain Diseases1CTD_human
HgeneAPPC0011573Endogenous depression1PSYGENET
HgeneAPPC0016667Fragile X Syndrome1CTD_human
HgeneAPPC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneAPPC0027540Necrosis1CTD_human
HgeneAPPC0033141Cardiomyopathies, Primary1CTD_human
HgeneAPPC0036529Myocardial Diseases, Secondary1CTD_human
HgeneAPPC0036572Seizures1GENOMICS_ENGLAND
HgeneAPPC0037928Spinal Cord Diseases1CTD_human
HgeneAPPC0038002Splenomegaly1CTD_human
HgeneAPPC0038454Cerebrovascular accident1GENOMICS_ENGLAND
HgeneAPPC0043094Weight Gain1CTD_human
HgeneAPPC0085220Cerebral Amyloid Angiopathy1CTD_human
HgeneAPPC0085584Encephalopathies1CTD_human
HgeneAPPC0231341Premature aging syndrome1CTD_human
HgeneAPPC0233750Hysterical amnesia1CTD_human
HgeneAPPC0233796Temporary Amnesia1CTD_human
HgeneAPPC0234985Mental deterioration1CTD_human
HgeneAPPC0236795Dissociative Amnesia1CTD_human
HgeneAPPC0262497Global Amnesia1CTD_human
HgeneAPPC0270612Leukoencephalopathy1GENOMICS_ENGLAND
HgeneAPPC0338582Sporadic Cerebral Amyloid Angiopathy1CTD_human
HgeneAPPC0338630Senile Paranoid Dementia1CTD_human
HgeneAPPC0338656Impaired cognition1CTD_human
HgeneAPPC0376280Anxiety States, Neurotic1CTD_human
HgeneAPPC0553692Brain hemorrhage1GENOMICS_ENGLAND
HgeneAPPC0750906Tactile Amnesia1CTD_human
HgeneAPPC0750907Amnestic State1CTD_human
HgeneAPPC0751071Familial Dementia1CTD_human
HgeneAPPC0751156FRAXA Syndrome1CTD_human
HgeneAPPC0751157FRAXE Syndrome1CTD_human
HgeneAPPC0878544Cardiomyopathies1CTD_human
HgeneAPPC0948008Ischemic stroke1GENOMICS_ENGLAND
HgeneAPPC1270972Mild cognitive disorder1CTD_human
HgeneAPPC1279420Anxiety neurosis (finding)1CTD_human