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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:IL6ST-DDX4 (FusionGDB2 ID:HG3572TG54514) |
Fusion Gene Summary for IL6ST-DDX4 |
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Fusion gene information | Fusion gene name: IL6ST-DDX4 | Fusion gene ID: hg3572tg54514 | Hgene | Tgene | Gene symbol | IL6ST | DDX4 | Gene ID | 3572 | 54514 |
Gene name | interleukin 6 signal transducer | DEAD-box helicase 4 | |
Synonyms | CD130|CDW130|GP130|HIES4|IL-6RB|sGP130 | VASA | |
Cytomap | ('IL6ST')('DDX4') 5q11.2 | 5q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | interleukin-6 receptor subunit betaCD130 antigenIL-6 receptor subunit betaIL-6R subunit betagp130 of the rheumatoid arthritis antigenic peptide-bearing soluble formgp130, oncostatin M receptorinterleukin receptor beta chainmembrane glycoprotein 130 | probable ATP-dependent RNA helicase DDX4DEAD (Asp-Glu-Ala-Asp) box polypeptide 4DEAD box protein 4DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4vasa homolog | |
Modification date | 20200327 | 20200313 | |
UniProtAcc | P40189 | . | |
Ensembl transtripts involved in fusion gene | ENST00000336909, ENST00000381286, ENST00000381287, ENST00000381293, ENST00000381294, ENST00000381298, ENST00000396816, ENST00000502326, ENST00000522633, ENST00000536319, ENST00000577363, | ||
Fusion gene scores | * DoF score | 16 X 11 X 5=880 | 4 X 3 X 3=36 |
# samples | 19 | 4 | |
** MAII score | log2(19/880*10)=-2.21150410519371 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: IL6ST [Title/Abstract] AND DDX4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | IL6ST(55272043)-DDX4(55034778), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | IL6ST | GO:0008284 | positive regulation of cell proliferation | 2261637 |
Hgene | IL6ST | GO:0019221 | cytokine-mediated signaling pathway | 2261637 |
Hgene | IL6ST | GO:0034097 | response to cytokine | 2261637|8999038 |
Hgene | IL6ST | GO:0048861 | leukemia inhibitory factor signaling pathway | 8999038|12643274 |
Hgene | IL6ST | GO:0070120 | ciliary neurotrophic factor-mediated signaling pathway | 12643274 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | PRAD | TCGA-ZG-A9L2-01A | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
ChimerDB4 | PRAD | TCGA-ZG-A9L2 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
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Fusion Gene ORF analysis for IL6ST-DDX4 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000336909 | ENST00000354991 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000336909 | ENST00000508580 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000381286 | ENST00000354991 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000381286 | ENST00000508580 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000381287 | ENST00000354991 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000381287 | ENST00000508580 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000381293 | ENST00000354991 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000381293 | ENST00000508580 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000381294 | ENST00000354991 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000381294 | ENST00000508580 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000381298 | ENST00000354991 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000381298 | ENST00000508580 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000396816 | ENST00000354991 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000396816 | ENST00000508580 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000502326 | ENST00000354991 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000502326 | ENST00000508580 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000522633 | ENST00000354991 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000522633 | ENST00000508580 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000536319 | ENST00000354991 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-3UTR | ENST00000536319 | ENST00000508580 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000336909 | ENST00000353507 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000336909 | ENST00000505374 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000336909 | ENST00000514278 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000381286 | ENST00000353507 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000381286 | ENST00000505374 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000381286 | ENST00000514278 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000381287 | ENST00000353507 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000381287 | ENST00000505374 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000381287 | ENST00000514278 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000381293 | ENST00000353507 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000381293 | ENST00000505374 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000381293 | ENST00000514278 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000381294 | ENST00000353507 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000381294 | ENST00000505374 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000381294 | ENST00000514278 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000381298 | ENST00000353507 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000381298 | ENST00000505374 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000381298 | ENST00000514278 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000396816 | ENST00000353507 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000396816 | ENST00000505374 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000396816 | ENST00000514278 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000502326 | ENST00000353507 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000502326 | ENST00000505374 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000502326 | ENST00000514278 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000522633 | ENST00000353507 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000522633 | ENST00000505374 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000522633 | ENST00000514278 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000536319 | ENST00000353507 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000536319 | ENST00000505374 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-5UTR | ENST00000536319 | ENST00000514278 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-intron | ENST00000336909 | ENST00000511853 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-intron | ENST00000381286 | ENST00000511853 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-intron | ENST00000381287 | ENST00000511853 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-intron | ENST00000381293 | ENST00000511853 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-intron | ENST00000381294 | ENST00000511853 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-intron | ENST00000381298 | ENST00000511853 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-intron | ENST00000396816 | ENST00000511853 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-intron | ENST00000502326 | ENST00000511853 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-intron | ENST00000522633 | ENST00000511853 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5CDS-intron | ENST00000536319 | ENST00000511853 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5UTR-3UTR | ENST00000577363 | ENST00000354991 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5UTR-3UTR | ENST00000577363 | ENST00000508580 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5UTR-5UTR | ENST00000577363 | ENST00000353507 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5UTR-5UTR | ENST00000577363 | ENST00000505374 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5UTR-5UTR | ENST00000577363 | ENST00000514278 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
5UTR-intron | ENST00000577363 | ENST00000511853 | IL6ST | chr5 | 55272043 | - | DDX4 | chr5 | 55034778 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for IL6ST-DDX4 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
IL6ST | chr5 | 55272042 | - | DDX4 | chr5 | 55034777 | + | 5.54E-09 | 1 |
IL6ST | chr5 | 55272042 | - | DDX4 | chr5 | 55034777 | + | 5.54E-09 | 1 |
IL6ST | chr5 | 55272042 | - | DDX4 | chr5 | 55034777 | + | 5.54E-09 | 1 |
IL6ST | chr5 | 55272042 | - | DDX4 | chr5 | 55034777 | + | 5.54E-09 | 1 |
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Fusion Protein Features for IL6ST-DDX4 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:55272043/:55034778) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
IL6ST | . |
FUNCTION: Signal-transducing molecule (PubMed:2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activate the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:2261637, PubMed:19915009, PubMed:23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003, PubMed:25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity). {ECO:0000250|UniProtKB:Q00560, ECO:0000269|PubMed:19915009, ECO:0000269|PubMed:2261637, ECO:0000269|PubMed:23294003, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:28747427, ECO:0000269|PubMed:30309848}.; FUNCTION: [Isoform 2]: Binds to the soluble IL6:sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response (PubMed:11121117, PubMed:21990364, PubMed:30279168). Also blocks IL11 cluster signaling through IL11R (PubMed:30279168). {ECO:0000269|PubMed:11121117, ECO:0000269|PubMed:21990364, ECO:0000269|PubMed:30279168}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for IL6ST-DDX4 |
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Fusion Gene PPI Analysis for IL6ST-DDX4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for IL6ST-DDX4 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for IL6ST-DDX4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IL6ST | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
Hgene | IL6ST | C0376358 | Malignant neoplasm of prostate | 2 | CTD_human |
Hgene | IL6ST | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Hgene | IL6ST | C0007097 | Carcinoma | 1 | CTD_human |
Hgene | IL6ST | C0009402 | Colorectal Carcinoma | 1 | CTD_human;UNIPROT |
Hgene | IL6ST | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | IL6ST | C0013595 | Eczema | 1 | GENOMICS_ENGLAND |
Hgene | IL6ST | C0014457 | Eosinophilia | 1 | GENOMICS_ENGLAND |
Hgene | IL6ST | C0020517 | Hypersensitivity | 1 | CTD_human |
Hgene | IL6ST | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | IL6ST | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | IL6ST | C0032285 | Pneumonia | 1 | CTD_human |
Hgene | IL6ST | C0032300 | Lobar Pneumonia | 1 | CTD_human |
Hgene | IL6ST | C0035126 | Reperfusion Injury | 1 | CTD_human |
Hgene | IL6ST | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | IL6ST | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
Hgene | IL6ST | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
Hgene | IL6ST | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
Hgene | IL6ST | C0205699 | Carcinomatosis | 1 | CTD_human |
Hgene | IL6ST | C0236175 | Increased IgE level | 1 | GENOMICS_ENGLAND |
Hgene | IL6ST | C0238281 | Middle Cerebral Artery Syndrome | 1 | CTD_human |
Hgene | IL6ST | C0239998 | Recurrent infections | 1 | GENOMICS_ENGLAND |
Hgene | IL6ST | C0740376 | Middle Cerebral Artery Thrombosis | 1 | CTD_human |
Hgene | IL6ST | C0740391 | Middle Cerebral Artery Occlusion | 1 | CTD_human |
Hgene | IL6ST | C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human |
Hgene | IL6ST | C0751845 | Middle Cerebral Artery Embolus | 1 | CTD_human |
Hgene | IL6ST | C0751846 | Left Middle Cerebral Artery Infarction | 1 | CTD_human |
Hgene | IL6ST | C0751847 | Embolic Infarction, Middle Cerebral Artery | 1 | CTD_human |
Hgene | IL6ST | C0751848 | Thrombotic Infarction, Middle Cerebral Artery | 1 | CTD_human |
Hgene | IL6ST | C0751849 | Right Middle Cerebral Artery Infarction | 1 | CTD_human |
Hgene | IL6ST | C0887898 | Experimental Lung Inflammation | 1 | CTD_human |
Hgene | IL6ST | C0919267 | ovarian neoplasm | 1 | CTD_human |
Hgene | IL6ST | C1140680 | Malignant neoplasm of ovary | 1 | CTD_human |
Hgene | IL6ST | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human |
Hgene | IL6ST | C1527304 | Allergic Reaction | 1 | CTD_human |
Hgene | IL6ST | C3714636 | Pneumonitis | 1 | CTD_human |