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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IL12RB2-DAB1 (FusionGDB2 ID:HG3595TG1600)

Fusion Gene Summary for IL12RB2-DAB1

check button Fusion gene summary
Fusion gene informationFusion gene name: IL12RB2-DAB1
Fusion gene ID: hg3595tg1600
HgeneTgene
Gene symbol

IL12RB2

DAB1

Gene ID

3595

1600

Gene nameinterleukin 12 receptor subunit beta 2DAB adaptor protein 1
Synonyms-SCA37
Cytomap('IL12RB2')('DAB1')

1p31.3

1p32.2

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-12 receptor subunit beta-2IL-12 receptor subunit beta-2IL-12R subunit beta-2interleukin 12 receptor, beta 2interleukin-12 receptor beta-2 chaindisabled homolog 1DAB1, reelin adaptor proteinDab reelin signal transducer 1Dab, reelin signal transducer, homolog 1
Modification date2020031520200327
UniProtAcc

Q99665

O75553

Ensembl transtripts involved in fusion geneENST00000465396, ENST00000262345, 
ENST00000371000, ENST00000541374, 
ENST00000544434, 
Fusion gene scores* DoF score4 X 5 X 3=6015 X 12 X 7=1260
# samples 415
** MAII scorelog2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1260*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IL12RB2 [Title/Abstract] AND DAB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIL12RB2(67845806)-DAB1(57611102), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIL12RB2

GO:0032729

positive regulation of interferon-gamma production

11114383



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0AM-01AIL12RB2chr1

67845805

+DAB1chr1

57611101

-
ChimerDB4BRCATCGA-AN-A0AM-01AIL12RB2chr1

67845806

-DAB1chr1

57611102

-
ChimerDB4BRCATCGA-AN-A0AM-01AIL12RB2chr1

67845806

+DAB1chr1

57611102

-
ChimerDB4BRCATCGA-AN-A0AMIL12RB2chr1

67845806

+DAB1chr1

57611102

-


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Fusion Gene ORF analysis for IL12RB2-DAB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000465396ENST00000371230IL12RB2chr1

67845805

+DAB1chr1

57611101

-
3UTR-5UTRENST00000465396ENST00000371230IL12RB2chr1

67845806

+DAB1chr1

57611102

-
3UTR-5UTRENST00000465396ENST00000371231IL12RB2chr1

67845805

+DAB1chr1

57611101

-
3UTR-5UTRENST00000465396ENST00000371231IL12RB2chr1

67845806

+DAB1chr1

57611102

-
3UTR-5UTRENST00000465396ENST00000371234IL12RB2chr1

67845805

+DAB1chr1

57611101

-
3UTR-5UTRENST00000465396ENST00000371234IL12RB2chr1

67845806

+DAB1chr1

57611102

-
3UTR-5UTRENST00000465396ENST00000371236IL12RB2chr1

67845805

+DAB1chr1

57611101

-
3UTR-5UTRENST00000465396ENST00000371236IL12RB2chr1

67845806

+DAB1chr1

57611102

-
3UTR-5UTRENST00000465396ENST00000414851IL12RB2chr1

67845805

+DAB1chr1

57611101

-
3UTR-5UTRENST00000465396ENST00000414851IL12RB2chr1

67845806

+DAB1chr1

57611102

-
3UTR-5UTRENST00000465396ENST00000420954IL12RB2chr1

67845805

+DAB1chr1

57611101

-
3UTR-5UTRENST00000465396ENST00000420954IL12RB2chr1

67845806

+DAB1chr1

57611102

-
3UTR-5UTRENST00000465396ENST00000439789IL12RB2chr1

67845805

+DAB1chr1

57611101

-
3UTR-5UTRENST00000465396ENST00000439789IL12RB2chr1

67845806

+DAB1chr1

57611102

-
3UTR-5UTRENST00000465396ENST00000485760IL12RB2chr1

67845805

+DAB1chr1

57611101

-
3UTR-5UTRENST00000465396ENST00000485760IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000262345ENST00000371230IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000262345ENST00000371230IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000262345ENST00000371231IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000262345ENST00000371231IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000262345ENST00000371234IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000262345ENST00000371234IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000262345ENST00000371236IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000262345ENST00000371236IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000262345ENST00000414851IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000262345ENST00000414851IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000262345ENST00000420954IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000262345ENST00000420954IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000262345ENST00000439789IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000262345ENST00000439789IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000262345ENST00000485760IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000262345ENST00000485760IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000371000ENST00000371230IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000371000ENST00000371230IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000371000ENST00000371231IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000371000ENST00000371231IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000371000ENST00000371234IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000371000ENST00000371234IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000371000ENST00000371236IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000371000ENST00000371236IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000371000ENST00000414851IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000371000ENST00000414851IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000371000ENST00000420954IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000371000ENST00000420954IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000371000ENST00000439789IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000371000ENST00000439789IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000371000ENST00000485760IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000371000ENST00000485760IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000541374ENST00000371230IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000541374ENST00000371230IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000541374ENST00000371231IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000541374ENST00000371231IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000541374ENST00000371234IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000541374ENST00000371234IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000541374ENST00000371236IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000541374ENST00000371236IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000541374ENST00000414851IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000541374ENST00000414851IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000541374ENST00000420954IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000541374ENST00000420954IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000541374ENST00000439789IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000541374ENST00000439789IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000541374ENST00000485760IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000541374ENST00000485760IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000544434ENST00000371230IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000544434ENST00000371230IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000544434ENST00000371231IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000544434ENST00000371231IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000544434ENST00000371234IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000544434ENST00000371234IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000544434ENST00000371236IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000544434ENST00000371236IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000544434ENST00000414851IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000544434ENST00000414851IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000544434ENST00000420954IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000544434ENST00000420954IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000544434ENST00000439789IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000544434ENST00000439789IL12RB2chr1

67845806

+DAB1chr1

57611102

-
5CDS-5UTRENST00000544434ENST00000485760IL12RB2chr1

67845805

+DAB1chr1

57611101

-
5CDS-5UTRENST00000544434ENST00000485760IL12RB2chr1

67845806

+DAB1chr1

57611102

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for IL12RB2-DAB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for IL12RB2-DAB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:67845806/:57611102)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IL12RB2

Q99665

DAB1

O75553

FUNCTION: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.FUNCTION: Adapter molecule functioning in neural development. May regulate SIAH1 activity. {ECO:0000250|UniProtKB:P97318}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for IL12RB2-DAB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IL12RB2-DAB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IL12RB2-DAB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IL12RB2-DAB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC3889636SPINOCEREBELLAR ATAXIA 372GENOMICS_ENGLAND;ORPHANET
TgeneC0004352Autistic Disorder1CTD_human