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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ARF1-IFNGR1 (FusionGDB2 ID:HG375TG3459) |
Fusion Gene Summary for ARF1-IFNGR1 |
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Fusion gene information | Fusion gene name: ARF1-IFNGR1 | Fusion gene ID: hg375tg3459 | Hgene | Tgene | Gene symbol | ARF1 | IFNGR1 | Gene ID | 375 | 3459 |
Gene name | ADP ribosylation factor 1 | interferon gamma receptor 1 | |
Synonyms | PVNH8 | CD119|IFNGR|IMD27A|IMD27B | |
Cytomap | ('ARF1')('IFNGR1') 1q42.13 | 6q23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | ADP-ribosylation factor 1 | interferon gamma receptor 1AVP, type 2CD119 antigenCDw119IFN-gamma receptor 1IFN-gamma-R-alphaIFN-gamma-R1antiviral protein, type 2immune interferon receptor 1interferon-gamma receptor alpha chain | |
Modification date | 20200322 | 20200313 | |
UniProtAcc | P84077 | P15260 | |
Ensembl transtripts involved in fusion gene | ENST00000478424, ENST00000272102, ENST00000540651, ENST00000541182, | ||
Fusion gene scores | * DoF score | 18 X 9 X 7=1134 | 7 X 5 X 4=140 |
# samples | 18 | 9 | |
** MAII score | log2(18/1134*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/140*10)=-0.637429920615292 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ARF1 [Title/Abstract] AND IFNGR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ARF1(228270466)-IFNGR1(137528214), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | Non-Cancer | ERR315396 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
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Fusion Gene ORF analysis for ARF1-IFNGR1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000478424 | ENST00000367735 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
3UTR-3CDS | ENST00000478424 | ENST00000367739 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
3UTR-3CDS | ENST00000478424 | ENST00000543628 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
3UTR-5UTR | ENST00000478424 | ENST00000478333 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
5UTR-3CDS | ENST00000272102 | ENST00000367735 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
5UTR-3CDS | ENST00000272102 | ENST00000367739 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
5UTR-3CDS | ENST00000272102 | ENST00000543628 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
5UTR-3CDS | ENST00000540651 | ENST00000367735 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
5UTR-3CDS | ENST00000540651 | ENST00000367739 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
5UTR-3CDS | ENST00000540651 | ENST00000543628 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
5UTR-5UTR | ENST00000272102 | ENST00000478333 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
5UTR-5UTR | ENST00000540651 | ENST00000478333 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
intron-3CDS | ENST00000541182 | ENST00000367735 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
intron-3CDS | ENST00000541182 | ENST00000367739 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
intron-3CDS | ENST00000541182 | ENST00000543628 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
intron-5UTR | ENST00000541182 | ENST00000478333 | ARF1 | chr1 | 228270466 | + | IFNGR1 | chr6 | 137528214 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ARF1-IFNGR1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ARF1-IFNGR1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:228270466/:137528214) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ARF1 | IFNGR1 |
FUNCTION: GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000305}. | FUNCTION: Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114). Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents (PubMed:20015550). {ECO:0000269|PubMed:10986460, ECO:0000269|PubMed:20015550, ECO:0000269|PubMed:2971451, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7617032, ECO:0000269|PubMed:7673114}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ARF1-IFNGR1 |
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Fusion Gene PPI Analysis for ARF1-IFNGR1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARF1-IFNGR1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ARF1 | P84077 | DB09462 | Glycerin | Small molecule | Approved|Investigational | |
Tgene | IFNGR1 | P15260 | DB00033 | Interferon gamma-1b | Binder | Biotech | Approved|Investigational |
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Related Diseases for ARF1-IFNGR1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ARF1 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
Hgene | ARF1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | ARF1 | C0678222 | Breast Carcinoma | 1 | CTD_human |
Hgene | ARF1 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
Hgene | ARF1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | ARF1 | C1868720 | Periventricular Nodular Heterotopia | 1 | ORPHANET |
Hgene | ARF1 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
Hgene | ARF1 | C4748602 | PERIVENTRICULAR NODULAR HETEROTOPIA 8 | 1 | UNIPROT |
Tgene | C4011949 | IMMUNODEFICIENCY 27A | 14 | GENOMICS_ENGLAND;UNIPROT | |
Tgene | C0014175 | Endometriosis | 1 | CTD_human | |
Tgene | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human | |
Tgene | C0026918 | Mycobacterium Infections | 1 | GENOMICS_ENGLAND | |
Tgene | C0151744 | Myocardial Ischemia | 1 | CTD_human | |
Tgene | C0269102 | Endometrioma | 1 | CTD_human | |
Tgene | C4014863 | IMMUNODEFICIENCY 27B | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET |