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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KLC1-BTK (FusionGDB2 ID:HG3831TG695)

Fusion Gene Summary for KLC1-BTK

check button Fusion gene summary
Fusion gene informationFusion gene name: KLC1-BTK
Fusion gene ID: hg3831tg695
HgeneTgene
Gene symbol

KLC1

BTK

Gene ID

3831

695

Gene namekinesin light chain 1Bruton tyrosine kinase
SynonymsKLC|KNS2|KNS2AAGMX1|AT|ATK|BPK|IGHD3|IMD1|PSCTK1|XLA
Cytomap('KLC1')('BTK')

14q32.33

Xq22.1

Type of geneprotein-codingprotein-coding
Descriptionkinesin light chain 1kinesin 2 60/70kDamedulloblastoma antigen MU-MB-2.50tyrosine-protein kinase BTKB-cell progenitor kinaseBruton agammaglobulinemia tyrosine kinaseBruton's tyrosine kinaseagammaglobulinaemia tyrosine kinasedominant-negative kinase-deficient Brutons tyrosine kinasetruncated Bruton agammaglobulinemia tyro
Modification date2020031320200329
UniProtAcc

Q07866

.
Ensembl transtripts involved in fusion geneENST00000246489, ENST00000334553, 
ENST00000347839, ENST00000348520, 
ENST00000380038, ENST00000389744, 
ENST00000445352, ENST00000452929, 
ENST00000553286, ENST00000554280, 
ENST00000555836, ENST00000557450, 
ENST00000557575, 
Fusion gene scores* DoF score9 X 12 X 6=6482 X 2 X 2=8
# samples 162
** MAII scorelog2(16/648*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: KLC1 [Title/Abstract] AND BTK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKLC1(104129264)-BTK(100604944), # samples:1
Anticipated loss of major functional domain due to fusion event.KLC1-BTK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KLC1-BTK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KLC1-BTK seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
KLC1-BTK seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
KLC1-BTK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KLC1-BTK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
KLC1-BTK seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBTK

GO:0018108

peptidyl-tyrosine phosphorylation

11606584


check buttonFusion gene breakpoints across KLC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across BTK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A59ZKLC1chr14

104129264

+BTKchrX

100604944

-


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Fusion Gene ORF analysis for KLC1-BTK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000246489ENST00000464567KLC1chr14

104129264

+BTKchrX

100604944

-
5CDS-intronENST00000334553ENST00000464567KLC1chr14

104129264

+BTKchrX

100604944

-
5CDS-intronENST00000347839ENST00000464567KLC1chr14

104129264

+BTKchrX

100604944

-
5CDS-intronENST00000348520ENST00000464567KLC1chr14

104129264

+BTKchrX

100604944

-
5CDS-intronENST00000380038ENST00000464567KLC1chr14

104129264

+BTKchrX

100604944

-
5CDS-intronENST00000389744ENST00000464567KLC1chr14

104129264

+BTKchrX

100604944

-
5CDS-intronENST00000445352ENST00000464567KLC1chr14

104129264

+BTKchrX

100604944

-
5CDS-intronENST00000452929ENST00000464567KLC1chr14

104129264

+BTKchrX

100604944

-
5CDS-intronENST00000553286ENST00000464567KLC1chr14

104129264

+BTKchrX

100604944

-
5CDS-intronENST00000554280ENST00000464567KLC1chr14

104129264

+BTKchrX

100604944

-
5CDS-intronENST00000555836ENST00000464567KLC1chr14

104129264

+BTKchrX

100604944

-
5CDS-intronENST00000557450ENST00000464567KLC1chr14

104129264

+BTKchrX

100604944

-
5CDS-intronENST00000557575ENST00000464567KLC1chr14

104129264

+BTKchrX

100604944

-
Frame-shiftENST00000246489ENST00000308731KLC1chr14

104129264

+BTKchrX

100604944

-
Frame-shiftENST00000334553ENST00000308731KLC1chr14

104129264

+BTKchrX

100604944

-
Frame-shiftENST00000347839ENST00000308731KLC1chr14

104129264

+BTKchrX

100604944

-
Frame-shiftENST00000348520ENST00000308731KLC1chr14

104129264

+BTKchrX

100604944

-
Frame-shiftENST00000380038ENST00000308731KLC1chr14

104129264

+BTKchrX

100604944

-
Frame-shiftENST00000389744ENST00000308731KLC1chr14

104129264

+BTKchrX

100604944

-
Frame-shiftENST00000445352ENST00000308731KLC1chr14

104129264

+BTKchrX

100604944

-
Frame-shiftENST00000452929ENST00000308731KLC1chr14

104129264

+BTKchrX

100604944

-
Frame-shiftENST00000553286ENST00000308731KLC1chr14

104129264

+BTKchrX

100604944

-
Frame-shiftENST00000554280ENST00000308731KLC1chr14

104129264

+BTKchrX

100604944

-
Frame-shiftENST00000555836ENST00000308731KLC1chr14

104129264

+BTKchrX

100604944

-
Frame-shiftENST00000557450ENST00000308731KLC1chr14

104129264

+BTKchrX

100604944

-
Frame-shiftENST00000557575ENST00000308731KLC1chr14

104129264

+BTKchrX

100604944

-
In-frameENST00000246489ENST00000372880KLC1chr14

104129264

+BTKchrX

100604944

-
In-frameENST00000334553ENST00000372880KLC1chr14

104129264

+BTKchrX

100604944

-
In-frameENST00000347839ENST00000372880KLC1chr14

104129264

+BTKchrX

100604944

-
In-frameENST00000348520ENST00000372880KLC1chr14

104129264

+BTKchrX

100604944

-
In-frameENST00000380038ENST00000372880KLC1chr14

104129264

+BTKchrX

100604944

-
In-frameENST00000389744ENST00000372880KLC1chr14

104129264

+BTKchrX

100604944

-
In-frameENST00000445352ENST00000372880KLC1chr14

104129264

+BTKchrX

100604944

-
In-frameENST00000452929ENST00000372880KLC1chr14

104129264

+BTKchrX

100604944

-
In-frameENST00000553286ENST00000372880KLC1chr14

104129264

+BTKchrX

100604944

-
In-frameENST00000554280ENST00000372880KLC1chr14

104129264

+BTKchrX

100604944

-
In-frameENST00000555836ENST00000372880KLC1chr14

104129264

+BTKchrX

100604944

-
In-frameENST00000557450ENST00000372880KLC1chr14

104129264

+BTKchrX

100604944

-
In-frameENST00000557575ENST00000372880KLC1chr14

104129264

+BTKchrX

100604944

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000348520KLC1chr14104129264+ENST00000372880BTKchrX100604944-162611163191152277
ENST00000380038KLC1chr14104129264+ENST00000372880BTKchrX100604944-160010902931126277
ENST00000389744KLC1chr14104129264+ENST00000372880BTKchrX100604944-157610662691102277
ENST00000557575KLC1chr14104129264+ENST00000372880BTKchrX100604944-156610562591092277
ENST00000553286KLC1chr14104129264+ENST00000372880BTKchrX100604944-156610562591092277
ENST00000347839KLC1chr14104129264+ENST00000372880BTKchrX100604944-156610562591092277
ENST00000555836KLC1chr14104129264+ENST00000372880BTKchrX100604944-156610562591092277
ENST00000334553KLC1chr14104129264+ENST00000372880BTKchrX100604944-156610562591092277
ENST00000246489KLC1chr14104129264+ENST00000372880BTKchrX100604944-156210522551088277
ENST00000557450KLC1chr14104129264+ENST00000372880BTKchrX100604944-156210522551088277
ENST00000554280KLC1chr14104129264+ENST00000372880BTKchrX100604944-156210522551088277
ENST00000452929KLC1chr14104129264+ENST00000372880BTKchrX100604944-156210522551088277
ENST00000445352KLC1chr14104129264+ENST00000372880BTKchrX100604944-15009901991026275

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000348520ENST00000372880KLC1chr14104129264+BTKchrX100604944-0.0025633150.9974367
ENST00000380038ENST00000372880KLC1chr14104129264+BTKchrX100604944-0.0024347780.99756527
ENST00000389744ENST00000372880KLC1chr14104129264+BTKchrX100604944-0.0025919870.997408
ENST00000557575ENST00000372880KLC1chr14104129264+BTKchrX100604944-0.0026828170.99731714
ENST00000553286ENST00000372880KLC1chr14104129264+BTKchrX100604944-0.0026828170.99731714
ENST00000347839ENST00000372880KLC1chr14104129264+BTKchrX100604944-0.0026828170.99731714
ENST00000555836ENST00000372880KLC1chr14104129264+BTKchrX100604944-0.0026828170.99731714
ENST00000334553ENST00000372880KLC1chr14104129264+BTKchrX100604944-0.0026828170.99731714
ENST00000246489ENST00000372880KLC1chr14104129264+BTKchrX100604944-0.00263950.9973605
ENST00000557450ENST00000372880KLC1chr14104129264+BTKchrX100604944-0.00263950.9973605
ENST00000554280ENST00000372880KLC1chr14104129264+BTKchrX100604944-0.00263950.9973605
ENST00000452929ENST00000372880KLC1chr14104129264+BTKchrX100604944-0.00263950.9973605
ENST00000445352ENST00000372880KLC1chr14104129264+BTKchrX100604944-0.0024201160.9975799

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Fusion Genomic Features for KLC1-BTK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for KLC1-BTK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:104129264/chrX:100604944)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLC1

Q07866

.
FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKLC1chr14:104129264chrX:100604944ENST00000246489+51627_156265638.0Coiled coil.
HgeneKLC1chr14:104129264chrX:100604944ENST00000334553+51727_156265668.6666666666666Coiled coil.
HgeneKLC1chr14:104129264chrX:100604944ENST00000347839+51627_156265629.0Coiled coil.
HgeneKLC1chr14:104129264chrX:100604944ENST00000348520+51527_156265585.0Coiled coil.
HgeneKLC1chr14:104129264chrX:100604944ENST00000389744+51527_156265898.3333333333334Coiled coil.
HgeneKLC1chr14:104129264chrX:100604944ENST00000452929+51627_156265619.0Coiled coil.
HgeneKLC1chr14:104129264chrX:100604944ENST00000553286+51427_156265561.0Coiled coil.
HgeneKLC1chr14:104129264chrX:100604944ENST00000557450+51527_156265585.0Coiled coil.
HgeneKLC1chr14:104129264chrX:100604944ENST00000246489+516213_246265638.0RepeatNote=TPR 1
HgeneKLC1chr14:104129264chrX:100604944ENST00000334553+517213_246265668.6666666666666RepeatNote=TPR 1
HgeneKLC1chr14:104129264chrX:100604944ENST00000347839+516213_246265629.0RepeatNote=TPR 1
HgeneKLC1chr14:104129264chrX:100604944ENST00000348520+515213_246265585.0RepeatNote=TPR 1
HgeneKLC1chr14:104129264chrX:100604944ENST00000389744+515213_246265898.3333333333334RepeatNote=TPR 1
HgeneKLC1chr14:104129264chrX:100604944ENST00000452929+516213_246265619.0RepeatNote=TPR 1
HgeneKLC1chr14:104129264chrX:100604944ENST00000553286+514213_246265561.0RepeatNote=TPR 1
HgeneKLC1chr14:104129264chrX:100604944ENST00000557450+515213_246265585.0RepeatNote=TPR 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKLC1chr14:104129264chrX:100604944ENST00000246489+516255_288265638.0RepeatNote=TPR 2
HgeneKLC1chr14:104129264chrX:100604944ENST00000246489+516297_330265638.0RepeatNote=TPR 3
HgeneKLC1chr14:104129264chrX:100604944ENST00000246489+516339_372265638.0RepeatNote=TPR 4
HgeneKLC1chr14:104129264chrX:100604944ENST00000246489+516381_414265638.0RepeatNote=TPR 5
HgeneKLC1chr14:104129264chrX:100604944ENST00000246489+516464_497265638.0RepeatNote=TPR 6
HgeneKLC1chr14:104129264chrX:100604944ENST00000334553+517255_288265668.6666666666666RepeatNote=TPR 2
HgeneKLC1chr14:104129264chrX:100604944ENST00000334553+517297_330265668.6666666666666RepeatNote=TPR 3
HgeneKLC1chr14:104129264chrX:100604944ENST00000334553+517339_372265668.6666666666666RepeatNote=TPR 4
HgeneKLC1chr14:104129264chrX:100604944ENST00000334553+517381_414265668.6666666666666RepeatNote=TPR 5
HgeneKLC1chr14:104129264chrX:100604944ENST00000334553+517464_497265668.6666666666666RepeatNote=TPR 6
HgeneKLC1chr14:104129264chrX:100604944ENST00000347839+516255_288265629.0RepeatNote=TPR 2
HgeneKLC1chr14:104129264chrX:100604944ENST00000347839+516297_330265629.0RepeatNote=TPR 3
HgeneKLC1chr14:104129264chrX:100604944ENST00000347839+516339_372265629.0RepeatNote=TPR 4
HgeneKLC1chr14:104129264chrX:100604944ENST00000347839+516381_414265629.0RepeatNote=TPR 5
HgeneKLC1chr14:104129264chrX:100604944ENST00000347839+516464_497265629.0RepeatNote=TPR 6
HgeneKLC1chr14:104129264chrX:100604944ENST00000348520+515255_288265585.0RepeatNote=TPR 2
HgeneKLC1chr14:104129264chrX:100604944ENST00000348520+515297_330265585.0RepeatNote=TPR 3
HgeneKLC1chr14:104129264chrX:100604944ENST00000348520+515339_372265585.0RepeatNote=TPR 4
HgeneKLC1chr14:104129264chrX:100604944ENST00000348520+515381_414265585.0RepeatNote=TPR 5
HgeneKLC1chr14:104129264chrX:100604944ENST00000348520+515464_497265585.0RepeatNote=TPR 6
HgeneKLC1chr14:104129264chrX:100604944ENST00000389744+515255_288265898.3333333333334RepeatNote=TPR 2
HgeneKLC1chr14:104129264chrX:100604944ENST00000389744+515297_330265898.3333333333334RepeatNote=TPR 3
HgeneKLC1chr14:104129264chrX:100604944ENST00000389744+515339_372265898.3333333333334RepeatNote=TPR 4
HgeneKLC1chr14:104129264chrX:100604944ENST00000389744+515381_414265898.3333333333334RepeatNote=TPR 5
HgeneKLC1chr14:104129264chrX:100604944ENST00000389744+515464_497265898.3333333333334RepeatNote=TPR 6
HgeneKLC1chr14:104129264chrX:100604944ENST00000452929+516255_288265619.0RepeatNote=TPR 2
HgeneKLC1chr14:104129264chrX:100604944ENST00000452929+516297_330265619.0RepeatNote=TPR 3
HgeneKLC1chr14:104129264chrX:100604944ENST00000452929+516339_372265619.0RepeatNote=TPR 4
HgeneKLC1chr14:104129264chrX:100604944ENST00000452929+516381_414265619.0RepeatNote=TPR 5
HgeneKLC1chr14:104129264chrX:100604944ENST00000452929+516464_497265619.0RepeatNote=TPR 6
HgeneKLC1chr14:104129264chrX:100604944ENST00000553286+514255_288265561.0RepeatNote=TPR 2
HgeneKLC1chr14:104129264chrX:100604944ENST00000553286+514297_330265561.0RepeatNote=TPR 3
HgeneKLC1chr14:104129264chrX:100604944ENST00000553286+514339_372265561.0RepeatNote=TPR 4
HgeneKLC1chr14:104129264chrX:100604944ENST00000553286+514381_414265561.0RepeatNote=TPR 5
HgeneKLC1chr14:104129264chrX:100604944ENST00000553286+514464_497265561.0RepeatNote=TPR 6
HgeneKLC1chr14:104129264chrX:100604944ENST00000557450+515255_288265585.0RepeatNote=TPR 2
HgeneKLC1chr14:104129264chrX:100604944ENST00000557450+515297_330265585.0RepeatNote=TPR 3
HgeneKLC1chr14:104129264chrX:100604944ENST00000557450+515339_372265585.0RepeatNote=TPR 4
HgeneKLC1chr14:104129264chrX:100604944ENST00000557450+515381_414265585.0RepeatNote=TPR 5
HgeneKLC1chr14:104129264chrX:100604944ENST00000557450+515464_497265585.0RepeatNote=TPR 6
TgeneBTKchr14:104129264chrX:100604944ENST000003087311719214_274636660.0DomainSH3
TgeneBTKchr14:104129264chrX:100604944ENST000003087311719281_377636660.0DomainSH2
TgeneBTKchr14:104129264chrX:100604944ENST0000030873117193_133636660.0DomainPH
TgeneBTKchr14:104129264chrX:100604944ENST000003087311719402_655636660.0DomainProtein kinase
TgeneBTKchr14:104129264chrX:100604944ENST000003087311719581_588636660.0MotifNote=CAV1-binding
TgeneBTKchr14:104129264chrX:100604944ENST000003087311719408_416636660.0Nucleotide bindingATP
TgeneBTKchr14:104129264chrX:100604944ENST00000308731171912_24636660.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate 1-binding
TgeneBTKchr14:104129264chrX:100604944ENST000003087311719474_479636660.0RegionNote=Inhibitor-binding
TgeneBTKchr14:104129264chrX:100604944ENST000003087311719135_171636660.0Zinc fingerBtk-type


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Fusion Gene Sequence for KLC1-BTK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>42824_42824_1_KLC1-BTK_KLC1_chr14_104129264_ENST00000246489_BTK_chrX_100604944_ENST00000372880_length(transcript)=1562nt_BP=1052nt
CGAGCGGGACTGGCTGGGTCGGCTGGGCTGCTGGTGCGAGGAGCCGCGGGGCTGTGCTCGGCGGCCAAGGGGACAGCGCGTGGGTGGCCG
AGGATGCTGCGGGGCGGTAGCTCCGGCGCCCCTAGCTGGTGACTGCTGCGCCGTGCCTCACACAGCCGAGGCGGGCTCGGCGCACAGTCG
CTGCTCCGCGCGCGCGCCCGGCGGCGCTCCAGGTGCTGACAGCGCGAGAGAGCGCGGCCCTCAGGAGCAAGGCGAATGTATGACAACATG
TCCACAATGGTGTACATAAAGGAAGACAAGTTGGAGAAGCTTACACAGGATGAAATTATTTCTAAGACAAAGCAAGTAATTCAGGGGCTG
GAAGCTTTGAAGAATGAGCACAATTCCATTTTACAAAGTTTGCTGGAGACACTGAAGTGTTTGAAGAAAGATGATGAAAGTAATTTGGTG
GAGGAGAAATCAAACATGATCCGGAAGTCACTGGAGATGTTGGAGCTCGGCCTGAGTGAGGCACAGGTTATGATGGCTTTGTCAAATCAC
CTGAATGCTGTGGAGTCCGAGAAGCAGAAACTGCGTGCGCAGGTTCGTCGTCTGTGCCAGGAGAATCAGTGGCTACGGGATGAACTGGCC
AACACGCAGCAGAAACTGCAGAAGAGTGAGCAGTCTGTGGCTCAACTGGAGGAGGAGAAGAAGCATCTGGAGTTTATGAATCAGCTAAAA
AAATATGATGACGACATTTCCCCATCCGAGGACAAAGACACTGATTCTACCAAAGAGCCTCTGGATGACCTTTTCCCCAATGATGAAGAC
GACCCAGGGCAAGGAATCCAGCAGCAGCACAGCAGTGCAGCCGCGGCTGCCCAGCAGGGCGGCTACGAGATCCCCGCGCGGCTGCGGACG
CTCCACAACCTGGTGATCCAGTACGCCTCGCAGGGGCGCTACGAGGTAGCTGTGCCCCTCTGCAAGCAGGCCCTGGAGGACCTGGAGAAG
ACTTCAGGACACGACCACCCGGACGTGGCCACCATGCTCAACATCCTGGCCTTGGTGTACAGAAAGCAGATGAGCGTCCCACTTTCAAAA
TTCTTCTGAGCAATATTCTAGATGTCATGGATGAAGAATCCTGAGCTCGCCAATAAGCTTCTTGGTTCTACTTCTCTTCTCCACAAGCCC
CAATTTCACTTTCTCAGAGGAAATCCCAAGCTTAGGAGCCCTGGAGCCTTTGTGCTCCCACTCAATACAAAAAGGCCCCTCTCTACATCT
GGGAATGCACCTCTTCTTTGATTCCCTGGGATAGTGGCTTCTGAGCAAAGGCCAAGAAATTATTGTGCCTGAAATTTCCCGAGAGAATTA
AGACAGACTGAATTTGCGATGAAAATATTTTTTAGGAGGGAGGATGTAAATAGCCGCACAAAGGGGTCCAACAGCTCTTTGAGTAGGCAT
TTGGTAGAGCTTGGGGGTGTGTGTGTGGGGGTGGACCGAATTTGGCAAGAATGAAATGGTGTCATAAAGATGGGAGGGGAGGGTGTTTTG

>42824_42824_1_KLC1-BTK_KLC1_chr14_104129264_ENST00000246489_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP=
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM
ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS

--------------------------------------------------------------
>42824_42824_2_KLC1-BTK_KLC1_chr14_104129264_ENST00000334553_BTK_chrX_100604944_ENST00000372880_length(transcript)=1566nt_BP=1056nt
CGGCCGAGCGGGACTGGCTGGGTCGGCTGGGCTGCTGGTGCGAGGAGCCGCGGGGCTGTGCTCGGCGGCCAAGGGGACAGCGCGTGGGTG
GCCGAGGATGCTGCGGGGCGGTAGCTCCGGCGCCCCTAGCTGGTGACTGCTGCGCCGTGCCTCACACAGCCGAGGCGGGCTCGGCGCACA
GTCGCTGCTCCGCGCGCGCGCCCGGCGGCGCTCCAGGTGCTGACAGCGCGAGAGAGCGCGGCCCTCAGGAGCAAGGCGAATGTATGACAA
CATGTCCACAATGGTGTACATAAAGGAAGACAAGTTGGAGAAGCTTACACAGGATGAAATTATTTCTAAGACAAAGCAAGTAATTCAGGG
GCTGGAAGCTTTGAAGAATGAGCACAATTCCATTTTACAAAGTTTGCTGGAGACACTGAAGTGTTTGAAGAAAGATGATGAAAGTAATTT
GGTGGAGGAGAAATCAAACATGATCCGGAAGTCACTGGAGATGTTGGAGCTCGGCCTGAGTGAGGCACAGGTTATGATGGCTTTGTCAAA
TCACCTGAATGCTGTGGAGTCCGAGAAGCAGAAACTGCGTGCGCAGGTTCGTCGTCTGTGCCAGGAGAATCAGTGGCTACGGGATGAACT
GGCCAACACGCAGCAGAAACTGCAGAAGAGTGAGCAGTCTGTGGCTCAACTGGAGGAGGAGAAGAAGCATCTGGAGTTTATGAATCAGCT
AAAAAAATATGATGACGACATTTCCCCATCCGAGGACAAAGACACTGATTCTACCAAAGAGCCTCTGGATGACCTTTTCCCCAATGATGA
AGACGACCCAGGGCAAGGAATCCAGCAGCAGCACAGCAGTGCAGCCGCGGCTGCCCAGCAGGGCGGCTACGAGATCCCCGCGCGGCTGCG
GACGCTCCACAACCTGGTGATCCAGTACGCCTCGCAGGGGCGCTACGAGGTAGCTGTGCCCCTCTGCAAGCAGGCCCTGGAGGACCTGGA
GAAGACTTCAGGACACGACCACCCGGACGTGGCCACCATGCTCAACATCCTGGCCTTGGTGTACAGAAAGCAGATGAGCGTCCCACTTTC
AAAATTCTTCTGAGCAATATTCTAGATGTCATGGATGAAGAATCCTGAGCTCGCCAATAAGCTTCTTGGTTCTACTTCTCTTCTCCACAA
GCCCCAATTTCACTTTCTCAGAGGAAATCCCAAGCTTAGGAGCCCTGGAGCCTTTGTGCTCCCACTCAATACAAAAAGGCCCCTCTCTAC
ATCTGGGAATGCACCTCTTCTTTGATTCCCTGGGATAGTGGCTTCTGAGCAAAGGCCAAGAAATTATTGTGCCTGAAATTTCCCGAGAGA
ATTAAGACAGACTGAATTTGCGATGAAAATATTTTTTAGGAGGGAGGATGTAAATAGCCGCACAAAGGGGTCCAACAGCTCTTTGAGTAG
GCATTTGGTAGAGCTTGGGGGTGTGTGTGTGGGGGTGGACCGAATTTGGCAAGAATGAAATGGTGTCATAAAGATGGGAGGGGAGGGTGT

>42824_42824_2_KLC1-BTK_KLC1_chr14_104129264_ENST00000334553_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP=
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM
ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS

--------------------------------------------------------------
>42824_42824_3_KLC1-BTK_KLC1_chr14_104129264_ENST00000347839_BTK_chrX_100604944_ENST00000372880_length(transcript)=1566nt_BP=1056nt
CGGCCGAGCGGGACTGGCTGGGTCGGCTGGGCTGCTGGTGCGAGGAGCCGCGGGGCTGTGCTCGGCGGCCAAGGGGACAGCGCGTGGGTG
GCCGAGGATGCTGCGGGGCGGTAGCTCCGGCGCCCCTAGCTGGTGACTGCTGCGCCGTGCCTCACACAGCCGAGGCGGGCTCGGCGCACA
GTCGCTGCTCCGCGCGCGCGCCCGGCGGCGCTCCAGGTGCTGACAGCGCGAGAGAGCGCGGCCCTCAGGAGCAAGGCGAATGTATGACAA
CATGTCCACAATGGTGTACATAAAGGAAGACAAGTTGGAGAAGCTTACACAGGATGAAATTATTTCTAAGACAAAGCAAGTAATTCAGGG
GCTGGAAGCTTTGAAGAATGAGCACAATTCCATTTTACAAAGTTTGCTGGAGACACTGAAGTGTTTGAAGAAAGATGATGAAAGTAATTT
GGTGGAGGAGAAATCAAACATGATCCGGAAGTCACTGGAGATGTTGGAGCTCGGCCTGAGTGAGGCACAGGTTATGATGGCTTTGTCAAA
TCACCTGAATGCTGTGGAGTCCGAGAAGCAGAAACTGCGTGCGCAGGTTCGTCGTCTGTGCCAGGAGAATCAGTGGCTACGGGATGAACT
GGCCAACACGCAGCAGAAACTGCAGAAGAGTGAGCAGTCTGTGGCTCAACTGGAGGAGGAGAAGAAGCATCTGGAGTTTATGAATCAGCT
AAAAAAATATGATGACGACATTTCCCCATCCGAGGACAAAGACACTGATTCTACCAAAGAGCCTCTGGATGACCTTTTCCCCAATGATGA
AGACGACCCAGGGCAAGGAATCCAGCAGCAGCACAGCAGTGCAGCCGCGGCTGCCCAGCAGGGCGGCTACGAGATCCCCGCGCGGCTGCG
GACGCTCCACAACCTGGTGATCCAGTACGCCTCGCAGGGGCGCTACGAGGTAGCTGTGCCCCTCTGCAAGCAGGCCCTGGAGGACCTGGA
GAAGACTTCAGGACACGACCACCCGGACGTGGCCACCATGCTCAACATCCTGGCCTTGGTGTACAGAAAGCAGATGAGCGTCCCACTTTC
AAAATTCTTCTGAGCAATATTCTAGATGTCATGGATGAAGAATCCTGAGCTCGCCAATAAGCTTCTTGGTTCTACTTCTCTTCTCCACAA
GCCCCAATTTCACTTTCTCAGAGGAAATCCCAAGCTTAGGAGCCCTGGAGCCTTTGTGCTCCCACTCAATACAAAAAGGCCCCTCTCTAC
ATCTGGGAATGCACCTCTTCTTTGATTCCCTGGGATAGTGGCTTCTGAGCAAAGGCCAAGAAATTATTGTGCCTGAAATTTCCCGAGAGA
ATTAAGACAGACTGAATTTGCGATGAAAATATTTTTTAGGAGGGAGGATGTAAATAGCCGCACAAAGGGGTCCAACAGCTCTTTGAGTAG
GCATTTGGTAGAGCTTGGGGGTGTGTGTGTGGGGGTGGACCGAATTTGGCAAGAATGAAATGGTGTCATAAAGATGGGAGGGGAGGGTGT

>42824_42824_3_KLC1-BTK_KLC1_chr14_104129264_ENST00000347839_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP=
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM
ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS

--------------------------------------------------------------
>42824_42824_4_KLC1-BTK_KLC1_chr14_104129264_ENST00000348520_BTK_chrX_100604944_ENST00000372880_length(transcript)=1626nt_BP=1116nt
GGCGGGGCGCCGGGGGGAGCAACACTGAGACGCCATTTTCGGCGGCGGGAGCGGCGCAGGCGGCCGAGCGGGACTGGCTGGGTCGGCTGG
GCTGCTGGTGCGAGGAGCCGCGGGGCTGTGCTCGGCGGCCAAGGGGACAGCGCGTGGGTGGCCGAGGATGCTGCGGGGCGGTAGCTCCGG
CGCCCCTAGCTGGTGACTGCTGCGCCGTGCCTCACACAGCCGAGGCGGGCTCGGCGCACAGTCGCTGCTCCGCGCGCGCGCCCGGCGGCG
CTCCAGGTGCTGACAGCGCGAGAGAGCGCGGCCCTCAGGAGCAAGGCGAATGTATGACAACATGTCCACAATGGTGTACATAAAGGAAGA
CAAGTTGGAGAAGCTTACACAGGATGAAATTATTTCTAAGACAAAGCAAGTAATTCAGGGGCTGGAAGCTTTGAAGAATGAGCACAATTC
CATTTTACAAAGTTTGCTGGAGACACTGAAGTGTTTGAAGAAAGATGATGAAAGTAATTTGGTGGAGGAGAAATCAAACATGATCCGGAA
GTCACTGGAGATGTTGGAGCTCGGCCTGAGTGAGGCACAGGTTATGATGGCTTTGTCAAATCACCTGAATGCTGTGGAGTCCGAGAAGCA
GAAACTGCGTGCGCAGGTTCGTCGTCTGTGCCAGGAGAATCAGTGGCTACGGGATGAACTGGCCAACACGCAGCAGAAACTGCAGAAGAG
TGAGCAGTCTGTGGCTCAACTGGAGGAGGAGAAGAAGCATCTGGAGTTTATGAATCAGCTAAAAAAATATGATGACGACATTTCCCCATC
CGAGGACAAAGACACTGATTCTACCAAAGAGCCTCTGGATGACCTTTTCCCCAATGATGAAGACGACCCAGGGCAAGGAATCCAGCAGCA
GCACAGCAGTGCAGCCGCGGCTGCCCAGCAGGGCGGCTACGAGATCCCCGCGCGGCTGCGGACGCTCCACAACCTGGTGATCCAGTACGC
CTCGCAGGGGCGCTACGAGGTAGCTGTGCCCCTCTGCAAGCAGGCCCTGGAGGACCTGGAGAAGACTTCAGGACACGACCACCCGGACGT
GGCCACCATGCTCAACATCCTGGCCTTGGTGTACAGAAAGCAGATGAGCGTCCCACTTTCAAAATTCTTCTGAGCAATATTCTAGATGTC
ATGGATGAAGAATCCTGAGCTCGCCAATAAGCTTCTTGGTTCTACTTCTCTTCTCCACAAGCCCCAATTTCACTTTCTCAGAGGAAATCC
CAAGCTTAGGAGCCCTGGAGCCTTTGTGCTCCCACTCAATACAAAAAGGCCCCTCTCTACATCTGGGAATGCACCTCTTCTTTGATTCCC
TGGGATAGTGGCTTCTGAGCAAAGGCCAAGAAATTATTGTGCCTGAAATTTCCCGAGAGAATTAAGACAGACTGAATTTGCGATGAAAAT
ATTTTTTAGGAGGGAGGATGTAAATAGCCGCACAAAGGGGTCCAACAGCTCTTTGAGTAGGCATTTGGTAGAGCTTGGGGGTGTGTGTGT
GGGGGTGGACCGAATTTGGCAAGAATGAAATGGTGTCATAAAGATGGGAGGGGAGGGTGTTTTGATAAAATAAAATTACTAGAAAGCTTG

>42824_42824_4_KLC1-BTK_KLC1_chr14_104129264_ENST00000348520_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP=
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM
ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS

--------------------------------------------------------------
>42824_42824_5_KLC1-BTK_KLC1_chr14_104129264_ENST00000380038_BTK_chrX_100604944_ENST00000372880_length(transcript)=1600nt_BP=1090nt
GAGACGCCATTTTCGGCGGCGGGAGCGGCGCAGGCGGCCGAGCGGGACTGGCTGGGTCGGCTGGGCTGCTGGTGCGAGGAGCCGCGGGGC
TGTGCTCGGCGGCCAAGGGGACAGCGCGTGGGTGGCCGAGGATGCTGCGGGGCGGTAGCTCCGGCGCCCCTAGCTGGTGACTGCTGCGCC
GTGCCTCACACAGCCGAGGCGGGCTCGGCGCACAGTCGCTGCTCCGCGCGCGCGCCCGGCGGCGCTCCAGGTGCTGACAGCGCGAGAGAG
CGCGGCCCTCAGGAGCAAGGCGAATGTATGACAACATGTCCACAATGGTGTACATAAAGGAAGACAAGTTGGAGAAGCTTACACAGGATG
AAATTATTTCTAAGACAAAGCAAGTAATTCAGGGGCTGGAAGCTTTGAAGAATGAGCACAATTCCATTTTACAAAGTTTGCTGGAGACAC
TGAAGTGTTTGAAGAAAGATGATGAAAGTAATTTGGTGGAGGAGAAATCAAACATGATCCGGAAGTCACTGGAGATGTTGGAGCTCGGCC
TGAGTGAGGCACAGGTTATGATGGCTTTGTCAAATCACCTGAATGCTGTGGAGTCCGAGAAGCAGAAACTGCGTGCGCAGGTTCGTCGTC
TGTGCCAGGAGAATCAGTGGCTACGGGATGAACTGGCCAACACGCAGCAGAAACTGCAGAAGAGTGAGCAGTCTGTGGCTCAACTGGAGG
AGGAGAAGAAGCATCTGGAGTTTATGAATCAGCTAAAAAAATATGATGACGACATTTCCCCATCCGAGGACAAAGACACTGATTCTACCA
AAGAGCCTCTGGATGACCTTTTCCCCAATGATGAAGACGACCCAGGGCAAGGAATCCAGCAGCAGCACAGCAGTGCAGCCGCGGCTGCCC
AGCAGGGCGGCTACGAGATCCCCGCGCGGCTGCGGACGCTCCACAACCTGGTGATCCAGTACGCCTCGCAGGGGCGCTACGAGGTAGCTG
TGCCCCTCTGCAAGCAGGCCCTGGAGGACCTGGAGAAGACTTCAGGACACGACCACCCGGACGTGGCCACCATGCTCAACATCCTGGCCT
TGGTGTACAGAAAGCAGATGAGCGTCCCACTTTCAAAATTCTTCTGAGCAATATTCTAGATGTCATGGATGAAGAATCCTGAGCTCGCCA
ATAAGCTTCTTGGTTCTACTTCTCTTCTCCACAAGCCCCAATTTCACTTTCTCAGAGGAAATCCCAAGCTTAGGAGCCCTGGAGCCTTTG
TGCTCCCACTCAATACAAAAAGGCCCCTCTCTACATCTGGGAATGCACCTCTTCTTTGATTCCCTGGGATAGTGGCTTCTGAGCAAAGGC
CAAGAAATTATTGTGCCTGAAATTTCCCGAGAGAATTAAGACAGACTGAATTTGCGATGAAAATATTTTTTAGGAGGGAGGATGTAAATA
GCCGCACAAAGGGGTCCAACAGCTCTTTGAGTAGGCATTTGGTAGAGCTTGGGGGTGTGTGTGTGGGGGTGGACCGAATTTGGCAAGAAT

>42824_42824_5_KLC1-BTK_KLC1_chr14_104129264_ENST00000380038_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP=
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM
ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS

--------------------------------------------------------------
>42824_42824_6_KLC1-BTK_KLC1_chr14_104129264_ENST00000389744_BTK_chrX_100604944_ENST00000372880_length(transcript)=1576nt_BP=1066nt
GCGGCGCAGGCGGCCGAGCGGGACTGGCTGGGTCGGCTGGGCTGCTGGTGCGAGGAGCCGCGGGGCTGTGCTCGGCGGCCAAGGGGACAG
CGCGTGGGTGGCCGAGGATGCTGCGGGGCGGTAGCTCCGGCGCCCCTAGCTGGTGACTGCTGCGCCGTGCCTCACACAGCCGAGGCGGGC
TCGGCGCACAGTCGCTGCTCCGCGCGCGCGCCCGGCGGCGCTCCAGGTGCTGACAGCGCGAGAGAGCGCGGCCCTCAGGAGCAAGGCGAA
TGTATGACAACATGTCCACAATGGTGTACATAAAGGAAGACAAGTTGGAGAAGCTTACACAGGATGAAATTATTTCTAAGACAAAGCAAG
TAATTCAGGGGCTGGAAGCTTTGAAGAATGAGCACAATTCCATTTTACAAAGTTTGCTGGAGACACTGAAGTGTTTGAAGAAAGATGATG
AAAGTAATTTGGTGGAGGAGAAATCAAACATGATCCGGAAGTCACTGGAGATGTTGGAGCTCGGCCTGAGTGAGGCACAGGTTATGATGG
CTTTGTCAAATCACCTGAATGCTGTGGAGTCCGAGAAGCAGAAACTGCGTGCGCAGGTTCGTCGTCTGTGCCAGGAGAATCAGTGGCTAC
GGGATGAACTGGCCAACACGCAGCAGAAACTGCAGAAGAGTGAGCAGTCTGTGGCTCAACTGGAGGAGGAGAAGAAGCATCTGGAGTTTA
TGAATCAGCTAAAAAAATATGATGACGACATTTCCCCATCCGAGGACAAAGACACTGATTCTACCAAAGAGCCTCTGGATGACCTTTTCC
CCAATGATGAAGACGACCCAGGGCAAGGAATCCAGCAGCAGCACAGCAGTGCAGCCGCGGCTGCCCAGCAGGGCGGCTACGAGATCCCCG
CGCGGCTGCGGACGCTCCACAACCTGGTGATCCAGTACGCCTCGCAGGGGCGCTACGAGGTAGCTGTGCCCCTCTGCAAGCAGGCCCTGG
AGGACCTGGAGAAGACTTCAGGACACGACCACCCGGACGTGGCCACCATGCTCAACATCCTGGCCTTGGTGTACAGAAAGCAGATGAGCG
TCCCACTTTCAAAATTCTTCTGAGCAATATTCTAGATGTCATGGATGAAGAATCCTGAGCTCGCCAATAAGCTTCTTGGTTCTACTTCTC
TTCTCCACAAGCCCCAATTTCACTTTCTCAGAGGAAATCCCAAGCTTAGGAGCCCTGGAGCCTTTGTGCTCCCACTCAATACAAAAAGGC
CCCTCTCTACATCTGGGAATGCACCTCTTCTTTGATTCCCTGGGATAGTGGCTTCTGAGCAAAGGCCAAGAAATTATTGTGCCTGAAATT
TCCCGAGAGAATTAAGACAGACTGAATTTGCGATGAAAATATTTTTTAGGAGGGAGGATGTAAATAGCCGCACAAAGGGGTCCAACAGCT
CTTTGAGTAGGCATTTGGTAGAGCTTGGGGGTGTGTGTGTGGGGGTGGACCGAATTTGGCAAGAATGAAATGGTGTCATAAAGATGGGAG

>42824_42824_6_KLC1-BTK_KLC1_chr14_104129264_ENST00000389744_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP=
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM
ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS

--------------------------------------------------------------
>42824_42824_7_KLC1-BTK_KLC1_chr14_104129264_ENST00000445352_BTK_chrX_100604944_ENST00000372880_length(transcript)=1500nt_BP=990nt
CTCGGCGGCCAAGGGGACAGCGCGTGGGTGGCCGAGGATGCTGCGGGGCGGTAGCTCCGGCGCCCCTAGCTGGTGACTGCTGCGCCGTGC
CTCACACAGCCGAGGCGGGCTCGGCGCACAGTCGCTGCTCCGCGCGCGCGCCCGGCGGCGCTCCAGGTGCTGACAGCGCGAGAGAGCGCG
GCCCTCAGGAGCAAGGCGAATGTATGACAACATGTCCACAATGGTGTACATAAAGGAAGACAAGTTGGAGAAGCTTACACAGGATGAAAT
TATTTCTAAGACAAAGCAAGTAATTCAGGGGCTGGAAGCTTTGAAGAATGAGCACAATTCCATTTTACAAAGTTTGCTGGAGACACTGAA
GTGTTTGAAGAAAGATGATGAAAGTAATTTGGTGGAGGAGAAATCAAACATGATCCGGAAGTCACTGGAGATGTTGGAGCTCGGCCTGAG
TGAGGCACAGGTTATGATGGCTTTGTCAAATCACCTGAATGCTGTGGAGTCCGAGAAGCAGAAACTGCGTGCGCAGGTTCGTCGTCTGTG
CCAGGAGAATCAGTGGCTACGGGATGAACTGGCCAACACGCAGCAGAAACTGCAGAAGAGTGAGCAGTCTGTGGCTCAACTGGAGGAGGA
GAAGAAGCATCTGGAGTTTATGAATCAGCTAAAAAAATATGATGACGACATTTCCCCATCCGAGGACAAAGACACTGATTCTACCAAAGA
GCCTCTGGATGACCTTTTCCCCAATGATGAAGACGACCCAGGGCAAGGAATCCAGCAGCAGCACAGCAGTGCAGCCGCGGCTGCCCAGCA
GGGCGGCTACGAGATCCCCGCGCGGCTGCGGACGCTCCACAACCTGGTGATCCAGTACGCCTCGCAGGGGCGCTACGAGGTAGCTGTGCC
CCTCTGCAAGCAGGCCCTGGAGGACCTGGAGAAGACTTCAGGACACGACCACCCGGACGTGGCCACCATGCTCAACATCCTGGCCTTGGT
AAAGCAGATGAGCGTCCCACTTTCAAAATTCTTCTGAGCAATATTCTAGATGTCATGGATGAAGAATCCTGAGCTCGCCAATAAGCTTCT
TGGTTCTACTTCTCTTCTCCACAAGCCCCAATTTCACTTTCTCAGAGGAAATCCCAAGCTTAGGAGCCCTGGAGCCTTTGTGCTCCCACT
CAATACAAAAAGGCCCCTCTCTACATCTGGGAATGCACCTCTTCTTTGATTCCCTGGGATAGTGGCTTCTGAGCAAAGGCCAAGAAATTA
TTGTGCCTGAAATTTCCCGAGAGAATTAAGACAGACTGAATTTGCGATGAAAATATTTTTTAGGAGGGAGGATGTAAATAGCCGCACAAA
GGGGTCCAACAGCTCTTTGAGTAGGCATTTGGTAGAGCTTGGGGGTGTGTGTGTGGGGGTGGACCGAATTTGGCAAGAATGAAATGGTGT

>42824_42824_7_KLC1-BTK_KLC1_chr14_104129264_ENST00000445352_BTK_chrX_100604944_ENST00000372880_length(amino acids)=275AA_BP=
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM
ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVKQMSVP

--------------------------------------------------------------
>42824_42824_8_KLC1-BTK_KLC1_chr14_104129264_ENST00000452929_BTK_chrX_100604944_ENST00000372880_length(transcript)=1562nt_BP=1052nt
CGAGCGGGACTGGCTGGGTCGGCTGGGCTGCTGGTGCGAGGAGCCGCGGGGCTGTGCTCGGCGGCCAAGGGGACAGCGCGTGGGTGGCCG
AGGATGCTGCGGGGCGGTAGCTCCGGCGCCCCTAGCTGGTGACTGCTGCGCCGTGCCTCACACAGCCGAGGCGGGCTCGGCGCACAGTCG
CTGCTCCGCGCGCGCGCCCGGCGGCGCTCCAGGTGCTGACAGCGCGAGAGAGCGCGGCCCTCAGGAGCAAGGCGAATGTATGACAACATG
TCCACAATGGTGTACATAAAGGAAGACAAGTTGGAGAAGCTTACACAGGATGAAATTATTTCTAAGACAAAGCAAGTAATTCAGGGGCTG
GAAGCTTTGAAGAATGAGCACAATTCCATTTTACAAAGTTTGCTGGAGACACTGAAGTGTTTGAAGAAAGATGATGAAAGTAATTTGGTG
GAGGAGAAATCAAACATGATCCGGAAGTCACTGGAGATGTTGGAGCTCGGCCTGAGTGAGGCACAGGTTATGATGGCTTTGTCAAATCAC
CTGAATGCTGTGGAGTCCGAGAAGCAGAAACTGCGTGCGCAGGTTCGTCGTCTGTGCCAGGAGAATCAGTGGCTACGGGATGAACTGGCC
AACACGCAGCAGAAACTGCAGAAGAGTGAGCAGTCTGTGGCTCAACTGGAGGAGGAGAAGAAGCATCTGGAGTTTATGAATCAGCTAAAA
AAATATGATGACGACATTTCCCCATCCGAGGACAAAGACACTGATTCTACCAAAGAGCCTCTGGATGACCTTTTCCCCAATGATGAAGAC
GACCCAGGGCAAGGAATCCAGCAGCAGCACAGCAGTGCAGCCGCGGCTGCCCAGCAGGGCGGCTACGAGATCCCCGCGCGGCTGCGGACG
CTCCACAACCTGGTGATCCAGTACGCCTCGCAGGGGCGCTACGAGGTAGCTGTGCCCCTCTGCAAGCAGGCCCTGGAGGACCTGGAGAAG
ACTTCAGGACACGACCACCCGGACGTGGCCACCATGCTCAACATCCTGGCCTTGGTGTACAGAAAGCAGATGAGCGTCCCACTTTCAAAA
TTCTTCTGAGCAATATTCTAGATGTCATGGATGAAGAATCCTGAGCTCGCCAATAAGCTTCTTGGTTCTACTTCTCTTCTCCACAAGCCC
CAATTTCACTTTCTCAGAGGAAATCCCAAGCTTAGGAGCCCTGGAGCCTTTGTGCTCCCACTCAATACAAAAAGGCCCCTCTCTACATCT
GGGAATGCACCTCTTCTTTGATTCCCTGGGATAGTGGCTTCTGAGCAAAGGCCAAGAAATTATTGTGCCTGAAATTTCCCGAGAGAATTA
AGACAGACTGAATTTGCGATGAAAATATTTTTTAGGAGGGAGGATGTAAATAGCCGCACAAAGGGGTCCAACAGCTCTTTGAGTAGGCAT
TTGGTAGAGCTTGGGGGTGTGTGTGTGGGGGTGGACCGAATTTGGCAAGAATGAAATGGTGTCATAAAGATGGGAGGGGAGGGTGTTTTG

>42824_42824_8_KLC1-BTK_KLC1_chr14_104129264_ENST00000452929_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP=
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM
ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS

--------------------------------------------------------------
>42824_42824_9_KLC1-BTK_KLC1_chr14_104129264_ENST00000553286_BTK_chrX_100604944_ENST00000372880_length(transcript)=1566nt_BP=1056nt
CGGCCGAGCGGGACTGGCTGGGTCGGCTGGGCTGCTGGTGCGAGGAGCCGCGGGGCTGTGCTCGGCGGCCAAGGGGACAGCGCGTGGGTG
GCCGAGGATGCTGCGGGGCGGTAGCTCCGGCGCCCCTAGCTGGTGACTGCTGCGCCGTGCCTCACACAGCCGAGGCGGGCTCGGCGCACA
GTCGCTGCTCCGCGCGCGCGCCCGGCGGCGCTCCAGGTGCTGACAGCGCGAGAGAGCGCGGCCCTCAGGAGCAAGGCGAATGTATGACAA
CATGTCCACAATGGTGTACATAAAGGAAGACAAGTTGGAGAAGCTTACACAGGATGAAATTATTTCTAAGACAAAGCAAGTAATTCAGGG
GCTGGAAGCTTTGAAGAATGAGCACAATTCCATTTTACAAAGTTTGCTGGAGACACTGAAGTGTTTGAAGAAAGATGATGAAAGTAATTT
GGTGGAGGAGAAATCAAACATGATCCGGAAGTCACTGGAGATGTTGGAGCTCGGCCTGAGTGAGGCACAGGTTATGATGGCTTTGTCAAA
TCACCTGAATGCTGTGGAGTCCGAGAAGCAGAAACTGCGTGCGCAGGTTCGTCGTCTGTGCCAGGAGAATCAGTGGCTACGGGATGAACT
GGCCAACACGCAGCAGAAACTGCAGAAGAGTGAGCAGTCTGTGGCTCAACTGGAGGAGGAGAAGAAGCATCTGGAGTTTATGAATCAGCT
AAAAAAATATGATGACGACATTTCCCCATCCGAGGACAAAGACACTGATTCTACCAAAGAGCCTCTGGATGACCTTTTCCCCAATGATGA
AGACGACCCAGGGCAAGGAATCCAGCAGCAGCACAGCAGTGCAGCCGCGGCTGCCCAGCAGGGCGGCTACGAGATCCCCGCGCGGCTGCG
GACGCTCCACAACCTGGTGATCCAGTACGCCTCGCAGGGGCGCTACGAGGTAGCTGTGCCCCTCTGCAAGCAGGCCCTGGAGGACCTGGA
GAAGACTTCAGGACACGACCACCCGGACGTGGCCACCATGCTCAACATCCTGGCCTTGGTGTACAGAAAGCAGATGAGCGTCCCACTTTC
AAAATTCTTCTGAGCAATATTCTAGATGTCATGGATGAAGAATCCTGAGCTCGCCAATAAGCTTCTTGGTTCTACTTCTCTTCTCCACAA
GCCCCAATTTCACTTTCTCAGAGGAAATCCCAAGCTTAGGAGCCCTGGAGCCTTTGTGCTCCCACTCAATACAAAAAGGCCCCTCTCTAC
ATCTGGGAATGCACCTCTTCTTTGATTCCCTGGGATAGTGGCTTCTGAGCAAAGGCCAAGAAATTATTGTGCCTGAAATTTCCCGAGAGA
ATTAAGACAGACTGAATTTGCGATGAAAATATTTTTTAGGAGGGAGGATGTAAATAGCCGCACAAAGGGGTCCAACAGCTCTTTGAGTAG
GCATTTGGTAGAGCTTGGGGGTGTGTGTGTGGGGGTGGACCGAATTTGGCAAGAATGAAATGGTGTCATAAAGATGGGAGGGGAGGGTGT

>42824_42824_9_KLC1-BTK_KLC1_chr14_104129264_ENST00000553286_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP=
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM
ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS

--------------------------------------------------------------
>42824_42824_10_KLC1-BTK_KLC1_chr14_104129264_ENST00000554280_BTK_chrX_100604944_ENST00000372880_length(transcript)=1562nt_BP=1052nt
CGAGCGGGACTGGCTGGGTCGGCTGGGCTGCTGGTGCGAGGAGCCGCGGGGCTGTGCTCGGCGGCCAAGGGGACAGCGCGTGGGTGGCCG
AGGATGCTGCGGGGCGGTAGCTCCGGCGCCCCTAGCTGGTGACTGCTGCGCCGTGCCTCACACAGCCGAGGCGGGCTCGGCGCACAGTCG
CTGCTCCGCGCGCGCGCCCGGCGGCGCTCCAGGTGCTGACAGCGCGAGAGAGCGCGGCCCTCAGGAGCAAGGCGAATGTATGACAACATG
TCCACAATGGTGTACATAAAGGAAGACAAGTTGGAGAAGCTTACACAGGATGAAATTATTTCTAAGACAAAGCAAGTAATTCAGGGGCTG
GAAGCTTTGAAGAATGAGCACAATTCCATTTTACAAAGTTTGCTGGAGACACTGAAGTGTTTGAAGAAAGATGATGAAAGTAATTTGGTG
GAGGAGAAATCAAACATGATCCGGAAGTCACTGGAGATGTTGGAGCTCGGCCTGAGTGAGGCACAGGTTATGATGGCTTTGTCAAATCAC
CTGAATGCTGTGGAGTCCGAGAAGCAGAAACTGCGTGCGCAGGTTCGTCGTCTGTGCCAGGAGAATCAGTGGCTACGGGATGAACTGGCC
AACACGCAGCAGAAACTGCAGAAGAGTGAGCAGTCTGTGGCTCAACTGGAGGAGGAGAAGAAGCATCTGGAGTTTATGAATCAGCTAAAA
AAATATGATGACGACATTTCCCCATCCGAGGACAAAGACACTGATTCTACCAAAGAGCCTCTGGATGACCTTTTCCCCAATGATGAAGAC
GACCCAGGGCAAGGAATCCAGCAGCAGCACAGCAGTGCAGCCGCGGCTGCCCAGCAGGGCGGCTACGAGATCCCCGCGCGGCTGCGGACG
CTCCACAACCTGGTGATCCAGTACGCCTCGCAGGGGCGCTACGAGGTAGCTGTGCCCCTCTGCAAGCAGGCCCTGGAGGACCTGGAGAAG
ACTTCAGGACACGACCACCCGGACGTGGCCACCATGCTCAACATCCTGGCCTTGGTGTACAGAAAGCAGATGAGCGTCCCACTTTCAAAA
TTCTTCTGAGCAATATTCTAGATGTCATGGATGAAGAATCCTGAGCTCGCCAATAAGCTTCTTGGTTCTACTTCTCTTCTCCACAAGCCC
CAATTTCACTTTCTCAGAGGAAATCCCAAGCTTAGGAGCCCTGGAGCCTTTGTGCTCCCACTCAATACAAAAAGGCCCCTCTCTACATCT
GGGAATGCACCTCTTCTTTGATTCCCTGGGATAGTGGCTTCTGAGCAAAGGCCAAGAAATTATTGTGCCTGAAATTTCCCGAGAGAATTA
AGACAGACTGAATTTGCGATGAAAATATTTTTTAGGAGGGAGGATGTAAATAGCCGCACAAAGGGGTCCAACAGCTCTTTGAGTAGGCAT
TTGGTAGAGCTTGGGGGTGTGTGTGTGGGGGTGGACCGAATTTGGCAAGAATGAAATGGTGTCATAAAGATGGGAGGGGAGGGTGTTTTG

>42824_42824_10_KLC1-BTK_KLC1_chr14_104129264_ENST00000554280_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP=
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM
ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS

--------------------------------------------------------------
>42824_42824_11_KLC1-BTK_KLC1_chr14_104129264_ENST00000555836_BTK_chrX_100604944_ENST00000372880_length(transcript)=1566nt_BP=1056nt
CGGCCGAGCGGGACTGGCTGGGTCGGCTGGGCTGCTGGTGCGAGGAGCCGCGGGGCTGTGCTCGGCGGCCAAGGGGACAGCGCGTGGGTG
GCCGAGGATGCTGCGGGGCGGTAGCTCCGGCGCCCCTAGCTGGTGACTGCTGCGCCGTGCCTCACACAGCCGAGGCGGGCTCGGCGCACA
GTCGCTGCTCCGCGCGCGCGCCCGGCGGCGCTCCAGGTGCTGACAGCGCGAGAGAGCGCGGCCCTCAGGAGCAAGGCGAATGTATGACAA
CATGTCCACAATGGTGTACATAAAGGAAGACAAGTTGGAGAAGCTTACACAGGATGAAATTATTTCTAAGACAAAGCAAGTAATTCAGGG
GCTGGAAGCTTTGAAGAATGAGCACAATTCCATTTTACAAAGTTTGCTGGAGACACTGAAGTGTTTGAAGAAAGATGATGAAAGTAATTT
GGTGGAGGAGAAATCAAACATGATCCGGAAGTCACTGGAGATGTTGGAGCTCGGCCTGAGTGAGGCACAGGTTATGATGGCTTTGTCAAA
TCACCTGAATGCTGTGGAGTCCGAGAAGCAGAAACTGCGTGCGCAGGTTCGTCGTCTGTGCCAGGAGAATCAGTGGCTACGGGATGAACT
GGCCAACACGCAGCAGAAACTGCAGAAGAGTGAGCAGTCTGTGGCTCAACTGGAGGAGGAGAAGAAGCATCTGGAGTTTATGAATCAGCT
AAAAAAATATGATGACGACATTTCCCCATCCGAGGACAAAGACACTGATTCTACCAAAGAGCCTCTGGATGACCTTTTCCCCAATGATGA
AGACGACCCAGGGCAAGGAATCCAGCAGCAGCACAGCAGTGCAGCCGCGGCTGCCCAGCAGGGCGGCTACGAGATCCCCGCGCGGCTGCG
GACGCTCCACAACCTGGTGATCCAGTACGCCTCGCAGGGGCGCTACGAGGTAGCTGTGCCCCTCTGCAAGCAGGCCCTGGAGGACCTGGA
GAAGACTTCAGGACACGACCACCCGGACGTGGCCACCATGCTCAACATCCTGGCCTTGGTGTACAGAAAGCAGATGAGCGTCCCACTTTC
AAAATTCTTCTGAGCAATATTCTAGATGTCATGGATGAAGAATCCTGAGCTCGCCAATAAGCTTCTTGGTTCTACTTCTCTTCTCCACAA
GCCCCAATTTCACTTTCTCAGAGGAAATCCCAAGCTTAGGAGCCCTGGAGCCTTTGTGCTCCCACTCAATACAAAAAGGCCCCTCTCTAC
ATCTGGGAATGCACCTCTTCTTTGATTCCCTGGGATAGTGGCTTCTGAGCAAAGGCCAAGAAATTATTGTGCCTGAAATTTCCCGAGAGA
ATTAAGACAGACTGAATTTGCGATGAAAATATTTTTTAGGAGGGAGGATGTAAATAGCCGCACAAAGGGGTCCAACAGCTCTTTGAGTAG
GCATTTGGTAGAGCTTGGGGGTGTGTGTGTGGGGGTGGACCGAATTTGGCAAGAATGAAATGGTGTCATAAAGATGGGAGGGGAGGGTGT

>42824_42824_11_KLC1-BTK_KLC1_chr14_104129264_ENST00000555836_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP=
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM
ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS

--------------------------------------------------------------
>42824_42824_12_KLC1-BTK_KLC1_chr14_104129264_ENST00000557450_BTK_chrX_100604944_ENST00000372880_length(transcript)=1562nt_BP=1052nt
CGAGCGGGACTGGCTGGGTCGGCTGGGCTGCTGGTGCGAGGAGCCGCGGGGCTGTGCTCGGCGGCCAAGGGGACAGCGCGTGGGTGGCCG
AGGATGCTGCGGGGCGGTAGCTCCGGCGCCCCTAGCTGGTGACTGCTGCGCCGTGCCTCACACAGCCGAGGCGGGCTCGGCGCACAGTCG
CTGCTCCGCGCGCGCGCCCGGCGGCGCTCCAGGTGCTGACAGCGCGAGAGAGCGCGGCCCTCAGGAGCAAGGCGAATGTATGACAACATG
TCCACAATGGTGTACATAAAGGAAGACAAGTTGGAGAAGCTTACACAGGATGAAATTATTTCTAAGACAAAGCAAGTAATTCAGGGGCTG
GAAGCTTTGAAGAATGAGCACAATTCCATTTTACAAAGTTTGCTGGAGACACTGAAGTGTTTGAAGAAAGATGATGAAAGTAATTTGGTG
GAGGAGAAATCAAACATGATCCGGAAGTCACTGGAGATGTTGGAGCTCGGCCTGAGTGAGGCACAGGTTATGATGGCTTTGTCAAATCAC
CTGAATGCTGTGGAGTCCGAGAAGCAGAAACTGCGTGCGCAGGTTCGTCGTCTGTGCCAGGAGAATCAGTGGCTACGGGATGAACTGGCC
AACACGCAGCAGAAACTGCAGAAGAGTGAGCAGTCTGTGGCTCAACTGGAGGAGGAGAAGAAGCATCTGGAGTTTATGAATCAGCTAAAA
AAATATGATGACGACATTTCCCCATCCGAGGACAAAGACACTGATTCTACCAAAGAGCCTCTGGATGACCTTTTCCCCAATGATGAAGAC
GACCCAGGGCAAGGAATCCAGCAGCAGCACAGCAGTGCAGCCGCGGCTGCCCAGCAGGGCGGCTACGAGATCCCCGCGCGGCTGCGGACG
CTCCACAACCTGGTGATCCAGTACGCCTCGCAGGGGCGCTACGAGGTAGCTGTGCCCCTCTGCAAGCAGGCCCTGGAGGACCTGGAGAAG
ACTTCAGGACACGACCACCCGGACGTGGCCACCATGCTCAACATCCTGGCCTTGGTGTACAGAAAGCAGATGAGCGTCCCACTTTCAAAA
TTCTTCTGAGCAATATTCTAGATGTCATGGATGAAGAATCCTGAGCTCGCCAATAAGCTTCTTGGTTCTACTTCTCTTCTCCACAAGCCC
CAATTTCACTTTCTCAGAGGAAATCCCAAGCTTAGGAGCCCTGGAGCCTTTGTGCTCCCACTCAATACAAAAAGGCCCCTCTCTACATCT
GGGAATGCACCTCTTCTTTGATTCCCTGGGATAGTGGCTTCTGAGCAAAGGCCAAGAAATTATTGTGCCTGAAATTTCCCGAGAGAATTA
AGACAGACTGAATTTGCGATGAAAATATTTTTTAGGAGGGAGGATGTAAATAGCCGCACAAAGGGGTCCAACAGCTCTTTGAGTAGGCAT
TTGGTAGAGCTTGGGGGTGTGTGTGTGGGGGTGGACCGAATTTGGCAAGAATGAAATGGTGTCATAAAGATGGGAGGGGAGGGTGTTTTG

>42824_42824_12_KLC1-BTK_KLC1_chr14_104129264_ENST00000557450_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP=
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM
ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS

--------------------------------------------------------------
>42824_42824_13_KLC1-BTK_KLC1_chr14_104129264_ENST00000557575_BTK_chrX_100604944_ENST00000372880_length(transcript)=1566nt_BP=1056nt
CGGCCGAGCGGGACTGGCTGGGTCGGCTGGGCTGCTGGTGCGAGGAGCCGCGGGGCTGTGCTCGGCGGCCAAGGGGACAGCGCGTGGGTG
GCCGAGGATGCTGCGGGGCGGTAGCTCCGGCGCCCCTAGCTGGTGACTGCTGCGCCGTGCCTCACACAGCCGAGGCGGGCTCGGCGCACA
GTCGCTGCTCCGCGCGCGCGCCCGGCGGCGCTCCAGGTGCTGACAGCGCGAGAGAGCGCGGCCCTCAGGAGCAAGGCGAATGTATGACAA
CATGTCCACAATGGTGTACATAAAGGAAGACAAGTTGGAGAAGCTTACACAGGATGAAATTATTTCTAAGACAAAGCAAGTAATTCAGGG
GCTGGAAGCTTTGAAGAATGAGCACAATTCCATTTTACAAAGTTTGCTGGAGACACTGAAGTGTTTGAAGAAAGATGATGAAAGTAATTT
GGTGGAGGAGAAATCAAACATGATCCGGAAGTCACTGGAGATGTTGGAGCTCGGCCTGAGTGAGGCACAGGTTATGATGGCTTTGTCAAA
TCACCTGAATGCTGTGGAGTCCGAGAAGCAGAAACTGCGTGCGCAGGTTCGTCGTCTGTGCCAGGAGAATCAGTGGCTACGGGATGAACT
GGCCAACACGCAGCAGAAACTGCAGAAGAGTGAGCAGTCTGTGGCTCAACTGGAGGAGGAGAAGAAGCATCTGGAGTTTATGAATCAGCT
AAAAAAATATGATGACGACATTTCCCCATCCGAGGACAAAGACACTGATTCTACCAAAGAGCCTCTGGATGACCTTTTCCCCAATGATGA
AGACGACCCAGGGCAAGGAATCCAGCAGCAGCACAGCAGTGCAGCCGCGGCTGCCCAGCAGGGCGGCTACGAGATCCCCGCGCGGCTGCG
GACGCTCCACAACCTGGTGATCCAGTACGCCTCGCAGGGGCGCTACGAGGTAGCTGTGCCCCTCTGCAAGCAGGCCCTGGAGGACCTGGA
GAAGACTTCAGGACACGACCACCCGGACGTGGCCACCATGCTCAACATCCTGGCCTTGGTGTACAGAAAGCAGATGAGCGTCCCACTTTC
AAAATTCTTCTGAGCAATATTCTAGATGTCATGGATGAAGAATCCTGAGCTCGCCAATAAGCTTCTTGGTTCTACTTCTCTTCTCCACAA
GCCCCAATTTCACTTTCTCAGAGGAAATCCCAAGCTTAGGAGCCCTGGAGCCTTTGTGCTCCCACTCAATACAAAAAGGCCCCTCTCTAC
ATCTGGGAATGCACCTCTTCTTTGATTCCCTGGGATAGTGGCTTCTGAGCAAAGGCCAAGAAATTATTGTGCCTGAAATTTCCCGAGAGA
ATTAAGACAGACTGAATTTGCGATGAAAATATTTTTTAGGAGGGAGGATGTAAATAGCCGCACAAAGGGGTCCAACAGCTCTTTGAGTAG
GCATTTGGTAGAGCTTGGGGGTGTGTGTGTGGGGGTGGACCGAATTTGGCAAGAATGAAATGGTGTCATAAAGATGGGAGGGGAGGGTGT

>42824_42824_13_KLC1-BTK_KLC1_chr14_104129264_ENST00000557575_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP=
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM
ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF
PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KLC1-BTK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KLC1-BTK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KLC1-BTK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0221026X-linked agammaglobulinemia27CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0472813X-linked agammaglobulinemia with growth hormone deficiency4CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0001768Agammaglobulinemia1CTD_human
TgeneC0086438Hypogammaglobulinemia1CTD_human