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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:AFF3-C1D (FusionGDB2 ID:HG3899TG10438) |
Fusion Gene Summary for AFF3-C1D |
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Fusion gene information | Fusion gene name: AFF3-C1D | Fusion gene ID: hg3899tg10438 | Hgene | Tgene | Gene symbol | AFF3 | C1D | Gene ID | 3899 | 10438 |
Gene name | AF4/FMR2 family member 3 | C1D nuclear receptor corepressor | |
Synonyms | LAF4|MLLT2-like | LRP1|Rrp47|SUN-CoR|SUNCOR|hC1D | |
Cytomap | ('AFF3')('C1D') 2q11.2 | 2p14 | |
Type of gene | protein-coding | protein-coding | |
Description | AF4/FMR2 family member 3MLLT2-related proteinlymphoid nuclear protein 4lymphoid nuclear protein related to AF4protein LAF-4 | nuclear nucleic acid-binding protein C1DC1D DNA-binding proteinC1D nuclear receptor co-repressornuclear DNA-binding proteinsmall unique nuclear receptor co-repressorsmall unique nuclear receptor corepressor | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P51826 | Q13901 | |
Ensembl transtripts involved in fusion gene | ENST00000317233, ENST00000356421, ENST00000409236, ENST00000409579, ENST00000483600, | ||
Fusion gene scores | * DoF score | 17 X 13 X 7=1547 | 6 X 4 X 7=168 |
# samples | 17 | 11 | |
** MAII score | log2(17/1547*10)=-3.18586654531133 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/168*10)=-0.610957709254101 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: AFF3 [Title/Abstract] AND C1D [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | AFF3(100623094)-C1D(68274451), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | Non-Cancer | TCGA-BH-A1F6-11B | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
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Fusion Gene ORF analysis for AFF3-C1D |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000317233 | ENST00000355848 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000317233 | ENST00000407324 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000317233 | ENST00000409302 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000317233 | ENST00000410067 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000317233 | ENST00000470189 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000356421 | ENST00000355848 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000356421 | ENST00000407324 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000356421 | ENST00000409302 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000356421 | ENST00000410067 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000356421 | ENST00000470189 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000409236 | ENST00000355848 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000409236 | ENST00000407324 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000409236 | ENST00000409302 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000409236 | ENST00000410067 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000409236 | ENST00000470189 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000409579 | ENST00000355848 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000409579 | ENST00000407324 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000409579 | ENST00000409302 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000409579 | ENST00000410067 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
5CDS-5UTR | ENST00000409579 | ENST00000470189 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
intron-5UTR | ENST00000483600 | ENST00000355848 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
intron-5UTR | ENST00000483600 | ENST00000407324 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
intron-5UTR | ENST00000483600 | ENST00000409302 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
intron-5UTR | ENST00000483600 | ENST00000410067 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
intron-5UTR | ENST00000483600 | ENST00000470189 | AFF3 | chr2 | 100623094 | - | C1D | chr2 | 68274451 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for AFF3-C1D |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for AFF3-C1D |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:100623094/:68274451) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
AFF3 | C1D |
FUNCTION: Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA. | FUNCTION: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). {ECO:0000250, ECO:0000269|PubMed:10362552, ECO:0000269|PubMed:11801738, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:9679063}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for AFF3-C1D |
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Fusion Gene PPI Analysis for AFF3-C1D |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for AFF3-C1D |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for AFF3-C1D |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AFF3 | C0003873 | Rheumatoid Arthritis | 2 | CTD_human |
Hgene | AFF3 | C0013146 | Drug abuse | 1 | CTD_human |
Hgene | AFF3 | C0013170 | Drug habituation | 1 | CTD_human |
Hgene | AFF3 | C0013222 | Drug Use Disorders | 1 | CTD_human |
Hgene | AFF3 | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human |
Hgene | AFF3 | C0036572 | Seizures | 1 | GENOMICS_ENGLAND |
Hgene | AFF3 | C0038580 | Substance Dependence | 1 | CTD_human |
Hgene | AFF3 | C0038586 | Substance Use Disorders | 1 | CTD_human |
Hgene | AFF3 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Hgene | AFF3 | C0740858 | Substance abuse problem | 1 | CTD_human |
Hgene | AFF3 | C1510472 | Drug Dependence | 1 | CTD_human |
Hgene | AFF3 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
Hgene | AFF3 | C4316881 | Prescription Drug Abuse | 1 | CTD_human |
Tgene | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |