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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:AFF3-TMPRSS2 (FusionGDB2 ID:HG3899TG7113) |
Fusion Gene Summary for AFF3-TMPRSS2 |
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Fusion gene information | Fusion gene name: AFF3-TMPRSS2 | Fusion gene ID: hg3899tg7113 | Hgene | Tgene | Gene symbol | AFF3 | TMPRSS2 | Gene ID | 3899 | 7113 |
Gene name | AF4/FMR2 family member 3 | transmembrane serine protease 2 | |
Synonyms | LAF4|MLLT2-like | PP9284|PRSS10 | |
Cytomap | ('AFF3')('TMPRSS2') 2q11.2 | 21q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | AF4/FMR2 family member 3MLLT2-related proteinlymphoid nuclear protein 4lymphoid nuclear protein related to AF4protein LAF-4 | transmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P51826 | O15393 | |
Ensembl transtripts involved in fusion gene | ENST00000317233, ENST00000356421, ENST00000409236, ENST00000409579, ENST00000483600, | ||
Fusion gene scores | * DoF score | 17 X 13 X 7=1547 | 28 X 34 X 5=4760 |
# samples | 17 | 35 | |
** MAII score | log2(17/1547*10)=-3.18586654531133 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(35/4760*10)=-3.76553474636298 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: AFF3 [Title/Abstract] AND TMPRSS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | AFF3(100623094)-TMPRSS2(42870116), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TMPRSS2 | GO:0006508 | proteolysis | 21068237|24227843 |
Tgene | TMPRSS2 | GO:0046598 | positive regulation of viral entry into host cell | 21068237|24227843 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | PRAD | TCGA-G9-6384-01A | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
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Fusion Gene ORF analysis for AFF3-TMPRSS2 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000317233 | ENST00000332149 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
5CDS-5UTR | ENST00000317233 | ENST00000398585 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
5CDS-5UTR | ENST00000317233 | ENST00000458356 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
5CDS-5UTR | ENST00000317233 | ENST00000497881 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
5CDS-5UTR | ENST00000356421 | ENST00000332149 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
5CDS-5UTR | ENST00000356421 | ENST00000398585 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
5CDS-5UTR | ENST00000356421 | ENST00000458356 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
5CDS-5UTR | ENST00000356421 | ENST00000497881 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
5CDS-5UTR | ENST00000409236 | ENST00000332149 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
5CDS-5UTR | ENST00000409236 | ENST00000398585 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
5CDS-5UTR | ENST00000409236 | ENST00000458356 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
5CDS-5UTR | ENST00000409236 | ENST00000497881 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
5CDS-5UTR | ENST00000409579 | ENST00000332149 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
5CDS-5UTR | ENST00000409579 | ENST00000398585 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
5CDS-5UTR | ENST00000409579 | ENST00000458356 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
5CDS-5UTR | ENST00000409579 | ENST00000497881 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
intron-5UTR | ENST00000483600 | ENST00000332149 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
intron-5UTR | ENST00000483600 | ENST00000398585 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
intron-5UTR | ENST00000483600 | ENST00000458356 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
intron-5UTR | ENST00000483600 | ENST00000497881 | AFF3 | chr2 | 100623094 | - | TMPRSS2 | chr21 | 42870116 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for AFF3-TMPRSS2 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for AFF3-TMPRSS2 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:100623094/:42870116) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
AFF3 | TMPRSS2 |
FUNCTION: Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA. | FUNCTION: Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity). {ECO:0000250|UniProtKB:Q9JIQ8, ECO:0000269|PubMed:15537383, ECO:0000269|PubMed:25122198, ECO:0000269|PubMed:26018085}.; FUNCTION: (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436, PubMed:34159616, PubMed:33051876). Upon SARS-CoV-2 infection, increases syncytia formation by accelerating the fusion process (PubMed:34159616, PubMed:33051876). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. {ECO:0000269|PubMed:21068237, ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651, ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32404436, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:34159616}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for AFF3-TMPRSS2 |
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Fusion Gene PPI Analysis for AFF3-TMPRSS2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for AFF3-TMPRSS2 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for AFF3-TMPRSS2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AFF3 | C0003873 | Rheumatoid Arthritis | 2 | CTD_human |
Hgene | AFF3 | C0013146 | Drug abuse | 1 | CTD_human |
Hgene | AFF3 | C0013170 | Drug habituation | 1 | CTD_human |
Hgene | AFF3 | C0013222 | Drug Use Disorders | 1 | CTD_human |
Hgene | AFF3 | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human |
Hgene | AFF3 | C0036572 | Seizures | 1 | GENOMICS_ENGLAND |
Hgene | AFF3 | C0038580 | Substance Dependence | 1 | CTD_human |
Hgene | AFF3 | C0038586 | Substance Use Disorders | 1 | CTD_human |
Hgene | AFF3 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Hgene | AFF3 | C0740858 | Substance abuse problem | 1 | CTD_human |
Hgene | AFF3 | C1510472 | Drug Dependence | 1 | CTD_human |
Hgene | AFF3 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
Hgene | AFF3 | C4316881 | Prescription Drug Abuse | 1 | CTD_human |
Tgene | C0033578 | Prostatic Neoplasms | 4 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 4 | CTD_human |