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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LIFR-C9 (FusionGDB2 ID:HG3977TG735)

Fusion Gene Summary for LIFR-C9

check button Fusion gene summary
Fusion gene informationFusion gene name: LIFR-C9
Fusion gene ID: hg3977tg735
HgeneTgene
Gene symbol

LIFR

C9

Gene ID

3977

735

Gene nameLIF receptor subunit alphacomplement C9
SynonymsCD118|LIF-R|SJS2|STWS|SWSARMD15|C9D
Cytomap('LIFR')('C9')

5p13.1

5p13.1

Type of geneprotein-codingprotein-coding
Descriptionleukemia inhibitory factor receptorCD118 antigenLIF receptorLIF receptor alphaleukemia inhibitory factor receptor alphacomplement component C9complement component 9
Modification date2020031320200313
UniProtAcc

P42702

P02748

Ensembl transtripts involved in fusion geneENST00000263409, ENST00000453190, 
ENST00000503088, 
Fusion gene scores* DoF score8 X 7 X 7=3927 X 6 X 4=168
# samples 88
** MAII scorelog2(8/392*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LIFR [Title/Abstract] AND C9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLIFR(38493708)-C9(39316131), # samples:3
Anticipated loss of major functional domain due to fusion event.LIFR-C9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LIFR-C9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LIFR-C9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LIFR-C9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LIFR-C9 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
LIFR-C9 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
LIFR-C9 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLIFR

GO:0008284

positive regulation of cell proliferation

7957045|8999038

HgeneLIFR

GO:0019221

cytokine-mediated signaling pathway

7957045

HgeneLIFR

GO:0034097

response to cytokine

8999038

HgeneLIFR

GO:0048861

leukemia inhibitory factor signaling pathway

8999038|12643274

HgeneLIFR

GO:0070120

ciliary neurotrophic factor-mediated signaling pathway

12643274

TgeneC9

GO:0001906

cell killing

26841934|30111885

TgeneC9

GO:0051260

protein homooligomerization

26841934|30111885


check buttonFusion gene breakpoints across LIFR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across C9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A26G-01ALIFRchr5

38493708

-C9chr5

39316131

-


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Fusion Gene ORF analysis for LIFR-C9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263409ENST00000509186LIFRchr5

38493708

-C9chr5

39316131

-
5CDS-5UTRENST00000453190ENST00000509186LIFRchr5

38493708

-C9chr5

39316131

-
5UTR-3CDSENST00000503088ENST00000263408LIFRchr5

38493708

-C9chr5

39316131

-
5UTR-5UTRENST00000503088ENST00000509186LIFRchr5

38493708

-C9chr5

39316131

-
Frame-shiftENST00000453190ENST00000263408LIFRchr5

38493708

-C9chr5

39316131

-
In-frameENST00000263409ENST00000263408LIFRchr5

38493708

-C9chr5

39316131

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000263409LIFRchr538493708-ENST00000263408C9chr539316131-423022281632277704

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263409ENST00000263408LIFRchr538493708-C9chr539316131-0.0001728590.9998272

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Fusion Genomic Features for LIFR-C9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for LIFR-C9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:38493708/chr5:39316131)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LIFR

P42702

C9

P02748

FUNCTION: Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.FUNCTION: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells (PubMed:9634479, PubMed:9212048, PubMed:26841934). C9 is the pore-forming subunit of the MAC (PubMed:4055801, PubMed:26841934, PubMed:30111885). {ECO:0000269|PubMed:26841934, ECO:0000269|PubMed:30111885, ECO:0000269|PubMed:4055801, ECO:0000269|PubMed:9212048, ECO:0000269|PubMed:9634479}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420335_4346881098.0DomainFibronectin type-III 2
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420435_5346881098.0DomainFibronectin type-III 3
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-142049_1386881098.0DomainFibronectin type-III 1
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420538_6296881098.0DomainFibronectin type-III 4
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420335_4346881098.0DomainFibronectin type-III 2
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420435_5346881098.0DomainFibronectin type-III 3
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-142049_1386881098.0DomainFibronectin type-III 1
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420538_6296881098.0DomainFibronectin type-III 4
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420519_5236881098.0MotifNote=WSXWS motif
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420519_5236881098.0MotifNote=WSXWS motif
TgeneC9chr5:38493708chr5:39316131ENST00000263408411510_540205560.0DomainNote=EGF-like
TgeneC9chr5:38493708chr5:39316131ENST00000263408411314_330205560.0TransmembraneBeta stranded
TgeneC9chr5:38493708chr5:39316131ENST00000263408411335_354205560.0TransmembraneBeta stranded

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420627_7196881098.0DomainFibronectin type-III 5
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420724_8336881098.0DomainFibronectin type-III 6
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420627_7196881098.0DomainFibronectin type-III 5
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420724_8336881098.0DomainFibronectin type-III 6
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420869_8776881098.0MotifNote=Box 1 motif
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420869_8776881098.0MotifNote=Box 1 motif
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-142045_8336881098.0Topological domainExtracellular
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420859_10976881098.0Topological domainCytoplasmic
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-142045_8336881098.0Topological domainExtracellular
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420859_10976881098.0Topological domainCytoplasmic
HgeneLIFRchr5:38493708chr5:39316131ENST00000263409-1420834_8586881098.0TransmembraneHelical
HgeneLIFRchr5:38493708chr5:39316131ENST00000453190-1420834_8586881098.0TransmembraneHelical
TgeneC9chr5:38493708chr5:39316131ENST00000263408411138_509205560.0DomainMACPF
TgeneC9chr5:38493708chr5:39316131ENST0000026340841142_95205560.0DomainTSP type-1
TgeneC9chr5:38493708chr5:39316131ENST0000026340841199_136205560.0DomainLDL-receptor class A


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Fusion Gene Sequence for LIFR-C9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>44655_44655_1_LIFR-C9_LIFR_chr5_38493708_ENST00000263409_C9_chr5_39316131_ENST00000263408_length(transcript)=4230nt_BP=2228nt
AATCCTAACCCTCTCTCCCAGAACGTGTCTCTGCTGCAAGGCACCGGGCCCTTTCGCTCTGCAGAACTGCACTTGCAAGACCATTATCAA
CTCCTAATCCCAGCTCAGAAAGGGAGCCTCTGCGACTCATTCATCGCCCTCCAGGACTGACTGCATTGCACAGATGATGGATATTTACGT
ATGTTTGAAACGACCATCCTGGATGGTGGACAATAAAAGAATGAGGACTGCTTCAAATTTCCAGTGGCTGTTATCAACATTTATTCTTCT
ATATCTAATGAATCAAGTAAATAGCCAGAAAAAGGGGGCTCCTCATGATTTGAAGTGTGTAACTAACAATTTGCAAGTGTGGAACTGTTC
TTGGAAAGCACCCTCTGGAACAGGCCGTGGTACTGATTATGAAGTTTGCATTGAAAACAGGTCCCGTTCTTGTTATCAGTTGGAGAAAAC
CAGTATTAAAATTCCAGCTCTTTCACATGGTGATTATGAAATAACAATAAATTCTCTACATGATTTTGGAAGTTCTACAAGTAAATTCAC
ACTAAATGAACAAAACGTTTCCTTAATTCCAGATACTCCAGAGATCTTGAATTTGTCTGCTGATTTCTCAACCTCTACATTATACCTAAA
GTGGAACGACAGGGGTTCAGTTTTTCCACACCGCTCAAATGTTATCTGGGAAATTAAAGTTCTACGTAAAGAGAGTATGGAGCTCGTAAA
ATTAGTGACCCACAACACAACTCTGAATGGCAAAGATACACTTCATCACTGGAGTTGGGCCTCAGATATGCCCTTGGAATGTGCCATTCA
TTTTGTGGAAATTAGATGCTACATTGACAATCTTCATTTTTCTGGTCTCGAAGAGTGGAGTGACTGGAGCCCTGTGAAGAACATTTCTTG
GATACCTGATTCTCAGACTAAGGTTTTTCCTCAAGATAAAGTGATACTTGTAGGCTCAGACATAACATTTTGTTGTGTGAGTCAAGAAAA
AGTGTTATCAGCACTGATTGGCCATACAAACTGCCCCTTGATCCATCTTGATGGGGAAAATGTTGCAATCAAGATTCGTAATATTTCTGT
TTCTGCAAGTAGTGGAACAAATGTAGTTTTTACAACCGAAGATAACATATTTGGAACCGTTATTTTTGCTGGATATCCACCAGATACTCC
TCAACAACTGAATTGTGAGACACATGATTTAAAAGAAATTATATGTAGTTGGAATCCAGGAAGGGTGACAGCGTTGGTGGGCCCACGTGC
TACAAGCTACACTTTAGTTGAAAGTTTTTCAGGAAAATATGTTAGACTTAAAAGAGCTGAAGCACCTACAAACGAAAGCTATCAATTATT
ATTTCAAATGCTTCCAAATCAAGAAATATATAATTTTACTTTGAATGCTCACAATCCGCTGGGTCGATCACAATCAACAATTTTAGTTAA
TATAACTGAAAAAGTTTATCCCCATACTCCTACTTCATTCAAAGTGAAGGATATTAATTCAACAGCTGTTAAACTTTCTTGGCATTTACC
AGGCAACTTTGCAAAGATTAATTTTTTATGTGAAATTGAAATTAAGAAATCTAATTCAGTACAAGAGCAGCGGAATGTCACAATCAAAGG
AGTAGAAAATTCAAGTTATCTTGTTGCTCTGGACAAGTTAAATCCATACACTCTATATACTTTTCGGATTCGTTGTTCTACTGAAACTTT
CTGGAAATGGAGCAAATGGAGCAATAAAAAACAACATTTAACAACAGAAGCCAGTCCTTCAAAGGGGCCTGATACTTGGAGAGAGTGGAG
TTCTGATGGAAAAAATTTAATAATCTATTGGAAGCCTTTACCCATTAATGAAGCTAATGGAAAAATACTTTCCTACAATGTATCGTGTTC
ATCAGATGAGGAAACACAGTCCCTTTCTGAAATCCCTGATCCTCAGCACAAAGCAGAGATACGACTTGATAAGAATGACTACATCATCAG
CGTAGTGGCTAAAAATTCTGTGGGCTCATCACCACCTTCCAAAATAGCGAGTATGGAAATTCCAAATGATGATCTCAAAATAGAACAAGT
TGTTGGGATGGGAAAGGGGATTCTCCTCACCTGGCATTACGACCCCAACATGACTTGCGACTACGTCATTAAGTGGTGTAACTCGTCTCG
GTCGGAACCATGCCTTATGGACTGGAGAAAAGTTCCCTCAAACAGCACTGAAACTGTAATAGAATCTGACCAAAGGCGAGAAAAATTTCA
GAACCGAACATTACGAAGAACAAATTGAAGCATTTAAAAGTATCATCCAAGAGAAGACATCAAATTTTAATGCAGCTATATCTCTAAAAT
TTACACCCACTGAAACAAATAAAGCTGAACAATGTTGTGAGGAAACAGCCTCCTCAATTTCTTTACATGGCAAGGGTAGTTTTCGGTTTT
CATATTCCAAAAATGAAACTTACCAACTATTTTTGTCATATTCTTCAAAGAAGGAAAAAATGTTTCTGCATGTGAAAGGAGAAATTCATC
TGGGAAGATTTGTAATGAGAAATCGCGATGTTGTGCTCACAACAACTTTTGTGGATGATATAAAAGCTTTGCCAACTACCTATGAAAAGG
GAGAATATTTTGCCTTTTTGGAAACCTATGGAACTCACTACAGTAGCTCTGGGTCTCTAGGAGGACTCTATGAACTAATATATGTTTTGG
ATAAAGCTTCCATGAAGCGGAAAGGTGTTGAACTAAAAGACATAAAGAGATGCCTTGGGTATCATCTGGATGTATCTCTGGCTTTCTCTG
AAATCTCTGTTGGAGCTGAATTTAATAAAGATGATTGTGTAAAGAGGGGAGAGGGTAGAGCTGTAAACATCACCAGTGAAAACCTCATAG
ATGATGTTGTTTCACTCATAAGAGGTGGAACCAGAAAATATGCATTTGAACTGAAAGAAAAGCTTCTCCGAGGAACCGTGATTGATGTGA
CTGACTTTGTCAACTGGGCCTCTTCCATAAATGATGCTCCTGTTCTCATTAGTCAAAAACTGTCTCCTATATATAATCTGGTTCCAGTGA
AAATGAAAAATGCACACCTAAAGAAACAAAACTTGGAAAGAGCCATTGAAGACTATATCAATGAATTTAGTGTAAGAAAATGCCACACAT
GCCAAAATGGAGGTACAGTGATTCTAATGGATGGAAAGTGTTTGTGTGCCTGCCCATTCAAATTTGAGGGAATTGCCTGTGAAATCAGTA
AACAAAAAATTTCTGAAGGATTGCCAGCCCTAGAGTTCCCCAATGAAAAATAGAGCTGTTGGCTTCTCTGAGCTCCAGTGGAAGAAGAAA
ACACTAGTACCTTCAGATCCTACCCCTGAAGATAATCTTAGCTGCCAAGTAAATAGCAACATGCTTCATGAAAATCCTACCAACCTCTGA
AGTCTCTTCTCTCTTAGGTCTATAATTTTTTTTTAAATTTTTCTTCCTTAAACTCCTGTGATGTTTCCATTTTTTGTTCCCTAATGAGAA
GTCAACAGTGAAATACGCCAGAACTGCTTTATCCCACGGAAAATGCCAATCTCTTCTAAAAAAAAACAAAATTAAATTAAAAACAGAATG
TTGGTTTAAAAAACTTCAAAGTAATTTTCAAACGGCTTTGTATGGTTAACATATTCTGCCAGGTCCATGACCACACGTCTGTACCATGCA
ATTTAACTCTTATTTACATTGTTATGTTTAGTTTGGTTATTTGCTTAGGTGTGCATACATTCATTCAGCAAATGCTGAGCACCAGCCACG
TGCACAGCAGTTGCTTTTACTAGTCTTAGCTCTACGATTTAAATCCATGTGTCCAAGGGGGAAAACATATTATATTTGTAACCAAAAACT
ACTAGTTTACCAGAGGACTGAAGGGAGATAAAGAGGAGTTGGTTAATGGGTACAAAAATCCAGTTAGATGAAAGGAATAATATAGATAGT
GTTCAGTAGCAGAATAGAATGAACATAAACTATTAGTTTAAATTATGTGAAATTCCTTCTATTTGATCATATTTTACAAGAAAAAACATC
AATTTTATATAGTCCAACTTAATACCTAGCCTTATGAGTTGTATAAGGTAAGGTTACCTACCTGAGAAGCTGATTAACATTGGTTGTACA
ATCTTATTCATTAGAGAACATGGTGCTTAGGGTCTGAGACCTTTTGAAAGGTCTGAGAACTCTTTAAAAAAAGGAAAGAAAGAAAGAAAA

>44655_44655_1_LIFR-C9_LIFR_chr5_38493708_ENST00000263409_C9_chr5_39316131_ENST00000263408_length(amino acids)=704AA_BP=688
MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSC
YQLEKTSIKIPALSHGDYEITINSLHDFGSSTSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE
SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFC
CVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA
LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVK
LSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD
TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LIFR-C9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LIFR-C9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneC9P02748DB09130CopperSmall moleculeApproved|Investigational

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Related Diseases for LIFR-C9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLIFRC0796176STUVE-WIEDEMANN SYNDROME3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneLIFRC0032460Polycystic Ovary Syndrome1CTD_human
HgeneLIFRC0033578Prostatic Neoplasms1CTD_human
HgeneLIFRC0036341Schizophrenia1PSYGENET
HgeneLIFRC0349398Paranoid delusion1PSYGENET
HgeneLIFRC0376358Malignant neoplasm of prostate1CTD_human
HgeneLIFRC0432240Stuve-Wiedemann dysplasia1ORPHANET
HgeneLIFRC1136382Sclerocystic Ovaries1CTD_human
HgeneLIFRC1968949Cakut1GENOMICS_ENGLAND
HgeneLIFRC2239176Liver carcinoma1CTD_human
TgeneC0003257Antibody Deficiency Syndrome2CTD_human
TgeneC0021051Immunologic Deficiency Syndromes2CTD_human
TgeneC2239176Liver carcinoma2CTD_human
TgeneC3151189C9 Deficiency2CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0011633Dermatomyositis1CTD_human
TgeneC0015456Facial Dermatoses1CTD_human
TgeneC0015704Favre-Racouchot Syndrome1CTD_human
TgeneC0025294Meningococcal meningitis1CTD_human
TgeneC0027412Opioid-Related Disorders1CTD_human
TgeneC0029095Opioid abuse1CTD_human
TgeneC0041834Erythema1CTD_human
TgeneC0221056Adult type dermatomyositis1CTD_human
TgeneC0242383Age related macular degeneration1CTD_human
TgeneC0263666Dermatomyositis, Childhood Type1CTD_human
TgeneC0272242Complement deficiency disease1GENOMICS_ENGLAND
TgeneC0343097Nodular Elastoidosis1CTD_human
TgeneC0345967Malignant mesothelioma1CTD_human
TgeneC0524661Narcotic Abuse1CTD_human
TgeneC0524662Opiate Addiction1CTD_human
TgeneC1135745Meningitis, Meningococcal, Serogroup A1CTD_human
TgeneC1135746Meningitis, Meningococcal, Serogroup B1CTD_human
TgeneC1135747Meningitis, Meningococcal, Serogroup C1CTD_human
TgeneC1136209Meningitis, Meningococcal, Serogroup Y1CTD_human
TgeneC1136210Meningitis, Meningococcal, Serogroup W-1351CTD_human
TgeneC1527402Narcotic Dependence1CTD_human
TgeneC3810042MACULAR DEGENERATION, AGE-RELATED, 151CTD_human;UNIPROT
TgeneC4551628Opiate Abuse1CTD_human