Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LIFR-C9 (FusionGDB2 ID:HG3977TG735)

Fusion Gene Summary for LIFR-C9

Fusion gene summary

Fusion gene information	Fusion gene name: LIFR-C9
	Fusion gene ID: hg3977tg735
		Hgene	Tgene
	Gene symbol	LIFR	C9
	Gene ID	3977	735
	Gene name	LIF receptor subunit alpha	complement C9
	Synonyms	CD118\|LIF-R\|SJS2\|STWS\|SWS	ARMD15\|C9D
	Cytomap	('LIFR')('C9') 5p13.1	5p13.1
	Type of gene	protein-coding	protein-coding
	Description	leukemia inhibitory factor receptorCD118 antigenLIF receptorLIF receptor alphaleukemia inhibitory factor receptor alpha	complement component C9complement component 9
	Modification date	20200313	20200313
	UniProtAcc	P42702	P02748
	Ensembl transtripts involved in fusion gene	ENST00000263409, ENST00000453190, ENST00000503088,
Fusion gene scores	* DoF score	8 X 7 X 7=392	7 X 6 X 4=168
	# samples	8	8
	** MAII score	log2(8/392*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LIFR [Title/Abstract] AND C9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LIFR(38493708)-C9(39316131), # samples:3
Anticipated loss of major functional domain due to fusion event.	LIFR-C9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LIFR-C9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LIFR-C9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LIFR-C9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LIFR-C9 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. LIFR-C9 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. LIFR-C9 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LIFR	GO:0008284	positive regulation of cell proliferation	7957045\|8999038
Hgene	LIFR	GO:0019221	cytokine-mediated signaling pathway	7957045
Hgene	LIFR	GO:0034097	response to cytokine	8999038
Hgene	LIFR	GO:0048861	leukemia inhibitory factor signaling pathway	8999038\|12643274
Hgene	LIFR	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	12643274
Tgene	C9	GO:0001906	cell killing	26841934\|30111885
Tgene	C9	GO:0051260	protein homooligomerization	26841934\|30111885

Fusion gene breakpoints across LIFR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A7-A26G-01A	LIFR	chr5	38493708	-	C9	chr5	39316131	-

Top

Fusion Gene ORF analysis for LIFR-C9

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000263409	ENST00000509186	LIFR	chr5	38493708	-	C9	chr5	39316131	-
5CDS-5UTR	ENST00000453190	ENST00000509186	LIFR	chr5	38493708	-	C9	chr5	39316131	-
5UTR-3CDS	ENST00000503088	ENST00000263408	LIFR	chr5	38493708	-	C9	chr5	39316131	-
5UTR-5UTR	ENST00000503088	ENST00000509186	LIFR	chr5	38493708	-	C9	chr5	39316131	-
Frame-shift	ENST00000453190	ENST00000263408	LIFR	chr5	38493708	-	C9	chr5	39316131	-
In-frame	ENST00000263409	ENST00000263408	LIFR	chr5	38493708	-	C9	chr5	39316131	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000263409

LIFR

chr5

38493708

ENST00000263408

chr5

39316131

4230

2228

163

2277

704

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000263409	ENST00000263408	LIFR	chr5	38493708	-	C9	chr5	39316131	-	0.000172859	0.9998272

Top

Fusion Genomic Features for LIFR-C9

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Top

Fusion Protein Features for LIFR-C9

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:38493708/chr5:39316131)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LIFR P42702	C9 P02748
FUNCTION: Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.	FUNCTION: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells (PubMed:9634479, PubMed:9212048, PubMed:26841934). C9 is the pore-forming subunit of the MAC (PubMed:4055801, PubMed:26841934, PubMed:30111885). {ECO:0000269\|PubMed:26841934, ECO:0000269\|PubMed:30111885, ECO:0000269\|PubMed:4055801, ECO:0000269\|PubMed:9212048, ECO:0000269\|PubMed:9634479}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000263409

335_434

688

1098.0

Domain

Fibronectin type-III 2

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000263409

435_534

688

1098.0

Domain

Fibronectin type-III 3

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000263409

49_138

688

1098.0

Domain

Fibronectin type-III 1

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000263409

538_629

688

1098.0

Domain

Fibronectin type-III 4

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000453190

335_434

688

1098.0

Domain

Fibronectin type-III 2

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000453190

435_534

688

1098.0

Domain

Fibronectin type-III 3

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000453190

49_138

688

1098.0

Domain

Fibronectin type-III 1

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000453190

538_629

688

1098.0

Domain

Fibronectin type-III 4

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000263409

519_523

688

1098.0

Motif

Note=WSXWS motif

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000453190

519_523

688

1098.0

Motif

Note=WSXWS motif

Tgene

chr5:38493708

chr5:39316131

ENST00000263408

510_540

205

560.0

Domain

Note=EGF-like

Tgene

chr5:38493708

chr5:39316131

ENST00000263408

314_330

205

560.0

Transmembrane

Beta stranded

Tgene

chr5:38493708

chr5:39316131

ENST00000263408

335_354

205

560.0

Transmembrane

Beta stranded

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000263409

627_719

688

1098.0

Domain

Fibronectin type-III 5

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000263409

724_833

688

1098.0

Domain

Fibronectin type-III 6

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000453190

627_719

688

1098.0

Domain

Fibronectin type-III 5

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000453190

724_833

688

1098.0

Domain

Fibronectin type-III 6

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000263409

869_877

688

1098.0

Motif

Note=Box 1 motif

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000453190

869_877

688

1098.0

Motif

Note=Box 1 motif

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000263409

45_833

688

1098.0

Topological domain

Extracellular

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000263409

859_1097

688

1098.0

Topological domain

Cytoplasmic

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000453190

45_833

688

1098.0

Topological domain

Extracellular

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000453190

859_1097

688

1098.0

Topological domain

Cytoplasmic

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000263409

834_858

688

1098.0

Transmembrane

Helical

Hgene

LIFR

chr5:38493708

chr5:39316131

ENST00000453190

834_858

688

1098.0

Transmembrane

Helical

Tgene

chr5:38493708

chr5:39316131

ENST00000263408

138_509

205

560.0

Domain

MACPF

Tgene

chr5:38493708

chr5:39316131

ENST00000263408

42_95

205

560.0

Domain

TSP type-1

Tgene

chr5:38493708

chr5:39316131

ENST00000263408

99_136

205

560.0

Domain

LDL-receptor class A

Top

Fusion Gene Sequence for LIFR-C9

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>44655_44655_1_LIFR-C9_LIFR_chr5_38493708_ENST00000263409_C9_chr5_39316131_ENST00000263408_length(transcript)=4230nt_BP=2228nt
AATCCTAACCCTCTCTCCCAGAACGTGTCTCTGCTGCAAGGCACCGGGCCCTTTCGCTCTGCAGAACTGCACTTGCAAGACCATTATCAA
CTCCTAATCCCAGCTCAGAAAGGGAGCCTCTGCGACTCATTCATCGCCCTCCAGGACTGACTGCATTGCACAGATGATGGATATTTACGT
ATGTTTGAAACGACCATCCTGGATGGTGGACAATAAAAGAATGAGGACTGCTTCAAATTTCCAGTGGCTGTTATCAACATTTATTCTTCT
ATATCTAATGAATCAAGTAAATAGCCAGAAAAAGGGGGCTCCTCATGATTTGAAGTGTGTAACTAACAATTTGCAAGTGTGGAACTGTTC
TTGGAAAGCACCCTCTGGAACAGGCCGTGGTACTGATTATGAAGTTTGCATTGAAAACAGGTCCCGTTCTTGTTATCAGTTGGAGAAAAC
CAGTATTAAAATTCCAGCTCTTTCACATGGTGATTATGAAATAACAATAAATTCTCTACATGATTTTGGAAGTTCTACAAGTAAATTCAC
ACTAAATGAACAAAACGTTTCCTTAATTCCAGATACTCCAGAGATCTTGAATTTGTCTGCTGATTTCTCAACCTCTACATTATACCTAAA
GTGGAACGACAGGGGTTCAGTTTTTCCACACCGCTCAAATGTTATCTGGGAAATTAAAGTTCTACGTAAAGAGAGTATGGAGCTCGTAAA
ATTAGTGACCCACAACACAACTCTGAATGGCAAAGATACACTTCATCACTGGAGTTGGGCCTCAGATATGCCCTTGGAATGTGCCATTCA
TTTTGTGGAAATTAGATGCTACATTGACAATCTTCATTTTTCTGGTCTCGAAGAGTGGAGTGACTGGAGCCCTGTGAAGAACATTTCTTG
GATACCTGATTCTCAGACTAAGGTTTTTCCTCAAGATAAAGTGATACTTGTAGGCTCAGACATAACATTTTGTTGTGTGAGTCAAGAAAA
AGTGTTATCAGCACTGATTGGCCATACAAACTGCCCCTTGATCCATCTTGATGGGGAAAATGTTGCAATCAAGATTCGTAATATTTCTGT
TTCTGCAAGTAGTGGAACAAATGTAGTTTTTACAACCGAAGATAACATATTTGGAACCGTTATTTTTGCTGGATATCCACCAGATACTCC
TCAACAACTGAATTGTGAGACACATGATTTAAAAGAAATTATATGTAGTTGGAATCCAGGAAGGGTGACAGCGTTGGTGGGCCCACGTGC
TACAAGCTACACTTTAGTTGAAAGTTTTTCAGGAAAATATGTTAGACTTAAAAGAGCTGAAGCACCTACAAACGAAAGCTATCAATTATT
ATTTCAAATGCTTCCAAATCAAGAAATATATAATTTTACTTTGAATGCTCACAATCCGCTGGGTCGATCACAATCAACAATTTTAGTTAA
TATAACTGAAAAAGTTTATCCCCATACTCCTACTTCATTCAAAGTGAAGGATATTAATTCAACAGCTGTTAAACTTTCTTGGCATTTACC
AGGCAACTTTGCAAAGATTAATTTTTTATGTGAAATTGAAATTAAGAAATCTAATTCAGTACAAGAGCAGCGGAATGTCACAATCAAAGG
AGTAGAAAATTCAAGTTATCTTGTTGCTCTGGACAAGTTAAATCCATACACTCTATATACTTTTCGGATTCGTTGTTCTACTGAAACTTT
CTGGAAATGGAGCAAATGGAGCAATAAAAAACAACATTTAACAACAGAAGCCAGTCCTTCAAAGGGGCCTGATACTTGGAGAGAGTGGAG
TTCTGATGGAAAAAATTTAATAATCTATTGGAAGCCTTTACCCATTAATGAAGCTAATGGAAAAATACTTTCCTACAATGTATCGTGTTC
ATCAGATGAGGAAACACAGTCCCTTTCTGAAATCCCTGATCCTCAGCACAAAGCAGAGATACGACTTGATAAGAATGACTACATCATCAG
CGTAGTGGCTAAAAATTCTGTGGGCTCATCACCACCTTCCAAAATAGCGAGTATGGAAATTCCAAATGATGATCTCAAAATAGAACAAGT
TGTTGGGATGGGAAAGGGGATTCTCCTCACCTGGCATTACGACCCCAACATGACTTGCGACTACGTCATTAAGTGGTGTAACTCGTCTCG
GTCGGAACCATGCCTTATGGACTGGAGAAAAGTTCCCTCAAACAGCACTGAAACTGTAATAGAATCTGACCAAAGGCGAGAAAAATTTCA
GAACCGAACATTACGAAGAACAAATTGAAGCATTTAAAAGTATCATCCAAGAGAAGACATCAAATTTTAATGCAGCTATATCTCTAAAAT
TTACACCCACTGAAACAAATAAAGCTGAACAATGTTGTGAGGAAACAGCCTCCTCAATTTCTTTACATGGCAAGGGTAGTTTTCGGTTTT
CATATTCCAAAAATGAAACTTACCAACTATTTTTGTCATATTCTTCAAAGAAGGAAAAAATGTTTCTGCATGTGAAAGGAGAAATTCATC
TGGGAAGATTTGTAATGAGAAATCGCGATGTTGTGCTCACAACAACTTTTGTGGATGATATAAAAGCTTTGCCAACTACCTATGAAAAGG
GAGAATATTTTGCCTTTTTGGAAACCTATGGAACTCACTACAGTAGCTCTGGGTCTCTAGGAGGACTCTATGAACTAATATATGTTTTGG
ATAAAGCTTCCATGAAGCGGAAAGGTGTTGAACTAAAAGACATAAAGAGATGCCTTGGGTATCATCTGGATGTATCTCTGGCTTTCTCTG
AAATCTCTGTTGGAGCTGAATTTAATAAAGATGATTGTGTAAAGAGGGGAGAGGGTAGAGCTGTAAACATCACCAGTGAAAACCTCATAG
ATGATGTTGTTTCACTCATAAGAGGTGGAACCAGAAAATATGCATTTGAACTGAAAGAAAAGCTTCTCCGAGGAACCGTGATTGATGTGA
CTGACTTTGTCAACTGGGCCTCTTCCATAAATGATGCTCCTGTTCTCATTAGTCAAAAACTGTCTCCTATATATAATCTGGTTCCAGTGA
AAATGAAAAATGCACACCTAAAGAAACAAAACTTGGAAAGAGCCATTGAAGACTATATCAATGAATTTAGTGTAAGAAAATGCCACACAT
GCCAAAATGGAGGTACAGTGATTCTAATGGATGGAAAGTGTTTGTGTGCCTGCCCATTCAAATTTGAGGGAATTGCCTGTGAAATCAGTA
AACAAAAAATTTCTGAAGGATTGCCAGCCCTAGAGTTCCCCAATGAAAAATAGAGCTGTTGGCTTCTCTGAGCTCCAGTGGAAGAAGAAA
ACACTAGTACCTTCAGATCCTACCCCTGAAGATAATCTTAGCTGCCAAGTAAATAGCAACATGCTTCATGAAAATCCTACCAACCTCTGA
AGTCTCTTCTCTCTTAGGTCTATAATTTTTTTTTAAATTTTTCTTCCTTAAACTCCTGTGATGTTTCCATTTTTTGTTCCCTAATGAGAA
GTCAACAGTGAAATACGCCAGAACTGCTTTATCCCACGGAAAATGCCAATCTCTTCTAAAAAAAAACAAAATTAAATTAAAAACAGAATG
TTGGTTTAAAAAACTTCAAAGTAATTTTCAAACGGCTTTGTATGGTTAACATATTCTGCCAGGTCCATGACCACACGTCTGTACCATGCA
ATTTAACTCTTATTTACATTGTTATGTTTAGTTTGGTTATTTGCTTAGGTGTGCATACATTCATTCAGCAAATGCTGAGCACCAGCCACG
TGCACAGCAGTTGCTTTTACTAGTCTTAGCTCTACGATTTAAATCCATGTGTCCAAGGGGGAAAACATATTATATTTGTAACCAAAAACT
ACTAGTTTACCAGAGGACTGAAGGGAGATAAAGAGGAGTTGGTTAATGGGTACAAAAATCCAGTTAGATGAAAGGAATAATATAGATAGT
GTTCAGTAGCAGAATAGAATGAACATAAACTATTAGTTTAAATTATGTGAAATTCCTTCTATTTGATCATATTTTACAAGAAAAAACATC
AATTTTATATAGTCCAACTTAATACCTAGCCTTATGAGTTGTATAAGGTAAGGTTACCTACCTGAGAAGCTGATTAACATTGGTTGTACA
ATCTTATTCATTAGAGAACATGGTGCTTAGGGTCTGAGACCTTTTGAAAGGTCTGAGAACTCTTTAAAAAAAGGAAAGAAAGAAAGAAAA

>44655_44655_1_LIFR-C9_LIFR_chr5_38493708_ENST00000263409_C9_chr5_39316131_ENST00000263408_length(amino acids)=704AA_BP=688
MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSC
YQLEKTSIKIPALSHGDYEITINSLHDFGSSTSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE
SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFC
CVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA
LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVK
LSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD
TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LIFR-C9

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LIFR-C9

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	C9	P02748	DB09130	Copper		Small molecule	Approved\|Investigational

Top

Related Diseases for LIFR-C9

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	LIFR	C0796176	STUVE-WIEDEMANN SYNDROME	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	LIFR	C0032460	Polycystic Ovary Syndrome	1	CTD_human
Hgene	LIFR	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	LIFR	C0036341	Schizophrenia	1	PSYGENET
Hgene	LIFR	C0349398	Paranoid delusion	1	PSYGENET
Hgene	LIFR	C0376358	Malignant neoplasm of prostate	1	CTD_human
Hgene	LIFR	C0432240	Stuve-Wiedemann dysplasia	1	ORPHANET
Hgene	LIFR	C1136382	Sclerocystic Ovaries	1	CTD_human
Hgene	LIFR	C1968949	Cakut	1	GENOMICS_ENGLAND
Hgene	LIFR	C2239176	Liver carcinoma	1	CTD_human
Tgene		C0003257	Antibody Deficiency Syndrome	2	CTD_human
Tgene		C0021051	Immunologic Deficiency Syndromes	2	CTD_human
Tgene		C2239176	Liver carcinoma	2	CTD_human
Tgene		C3151189	C9 Deficiency	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene		C0011633	Dermatomyositis	1	CTD_human
Tgene		C0015456	Facial Dermatoses	1	CTD_human
Tgene		C0015704	Favre-Racouchot Syndrome	1	CTD_human
Tgene		C0025294	Meningococcal meningitis	1	CTD_human
Tgene		C0027412	Opioid-Related Disorders	1	CTD_human
Tgene		C0029095	Opioid abuse	1	CTD_human
Tgene		C0041834	Erythema	1	CTD_human
Tgene		C0221056	Adult type dermatomyositis	1	CTD_human
Tgene		C0242383	Age related macular degeneration	1	CTD_human
Tgene		C0263666	Dermatomyositis, Childhood Type	1	CTD_human
Tgene		C0272242	Complement deficiency disease	1	GENOMICS_ENGLAND
Tgene		C0343097	Nodular Elastoidosis	1	CTD_human
Tgene		C0345967	Malignant mesothelioma	1	CTD_human
Tgene		C0524661	Narcotic Abuse	1	CTD_human
Tgene		C0524662	Opiate Addiction	1	CTD_human
Tgene		C1135745	Meningitis, Meningococcal, Serogroup A	1	CTD_human
Tgene		C1135746	Meningitis, Meningococcal, Serogroup B	1	CTD_human
Tgene		C1135747	Meningitis, Meningococcal, Serogroup C	1	CTD_human
Tgene		C1136209	Meningitis, Meningococcal, Serogroup Y	1	CTD_human
Tgene		C1136210	Meningitis, Meningococcal, Serogroup W-135	1	CTD_human
Tgene		C1527402	Narcotic Dependence	1	CTD_human
Tgene		C3810042	MACULAR DEGENERATION, AGE-RELATED, 15	1	CTD_human;UNIPROT
Tgene		C4551628	Opiate Abuse	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:LIFR-C9 (FusionGDB2 ID:HG3977TG735)

Fusion Gene Summary for LIFR-C9

Fusion Gene ORF analysis for LIFR-C9

Fusion Genomic Features for LIFR-C9

Fusion Protein Features for LIFR-C9

Fusion Gene Sequence for LIFR-C9

Fusion Gene PPI Analysis for LIFR-C9

Related Drugs for LIFR-C9

Related Diseases for LIFR-C9

Fusion Gene Studies
in Kim Lab