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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FADS1-TMEM138 (FusionGDB2 ID:HG3992TG51524)

Fusion Gene Summary for FADS1-TMEM138

check button Fusion gene summary
Fusion gene informationFusion gene name: FADS1-TMEM138
Fusion gene ID: hg3992tg51524
HgeneTgene
Gene symbol

FADS1

TMEM138

Gene ID

3992

51524

Gene namefatty acid desaturase 1transmembrane protein 138
SynonymsD5D|FADS6|FADSD5|LLCDL1|TU12HSPC196
Cytomap('FADS1')('TMEM138')

11q12.2

11q12.2

Type of geneprotein-codingprotein-coding
Descriptionacyl-CoA (8-3)-desaturasedelta(5) desaturasedelta-5 fatty acid desaturaselinoleoyl-CoA desaturase (delta-6-desaturase)-like 1transmembrane protein 138
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000350997, ENST00000433932, 
ENST00000542506, ENST00000460649, 
ENST00000536991, ENST00000541683, 
Fusion gene scores* DoF score7 X 8 X 2=1125 X 4 X 5=100
# samples 85
** MAII scorelog2(8/112*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FADS1 [Title/Abstract] AND TMEM138 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFADS1(61580715)-TMEM138(61135395), # samples:1
Anticipated loss of major functional domain due to fusion event.FADS1-TMEM138 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FADS1-TMEM138 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FADS1-TMEM138 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FADS1-TMEM138 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FADS1-TMEM138 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFADS1

GO:0006636

unsaturated fatty acid biosynthetic process

10601301

HgeneFADS1

GO:0009267

cellular response to starvation

10601301

HgeneFADS1

GO:0042759

long-chain fatty acid biosynthetic process

10601301


check buttonFusion gene breakpoints across FADS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TMEM138 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-NC-A5HJ-01AFADS1chr11

61580715

-TMEM138chr11

61135395

+


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Fusion Gene ORF analysis for FADS1-TMEM138

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000350997ENST00000542946FADS1chr11

61580715

-TMEM138chr11

61135395

+
5CDS-3UTRENST00000433932ENST00000542946FADS1chr11

61580715

-TMEM138chr11

61135395

+
5CDS-3UTRENST00000542506ENST00000542946FADS1chr11

61580715

-TMEM138chr11

61135395

+
5CDS-intronENST00000350997ENST00000381787FADS1chr11

61580715

-TMEM138chr11

61135395

+
5CDS-intronENST00000350997ENST00000540194FADS1chr11

61580715

-TMEM138chr11

61135395

+
5CDS-intronENST00000433932ENST00000381787FADS1chr11

61580715

-TMEM138chr11

61135395

+
5CDS-intronENST00000433932ENST00000540194FADS1chr11

61580715

-TMEM138chr11

61135395

+
5CDS-intronENST00000542506ENST00000381787FADS1chr11

61580715

-TMEM138chr11

61135395

+
5CDS-intronENST00000542506ENST00000540194FADS1chr11

61580715

-TMEM138chr11

61135395

+
Frame-shiftENST00000542506ENST00000278826FADS1chr11

61580715

-TMEM138chr11

61135395

+
In-frameENST00000350997ENST00000278826FADS1chr11

61580715

-TMEM138chr11

61135395

+
In-frameENST00000433932ENST00000278826FADS1chr11

61580715

-TMEM138chr11

61135395

+
intron-3CDSENST00000460649ENST00000278826FADS1chr11

61580715

-TMEM138chr11

61135395

+
intron-3CDSENST00000536991ENST00000278826FADS1chr11

61580715

-TMEM138chr11

61135395

+
intron-3CDSENST00000541683ENST00000278826FADS1chr11

61580715

-TMEM138chr11

61135395

+
intron-3UTRENST00000460649ENST00000542946FADS1chr11

61580715

-TMEM138chr11

61135395

+
intron-3UTRENST00000536991ENST00000542946FADS1chr11

61580715

-TMEM138chr11

61135395

+
intron-3UTRENST00000541683ENST00000542946FADS1chr11

61580715

-TMEM138chr11

61135395

+
intron-intronENST00000460649ENST00000381787FADS1chr11

61580715

-TMEM138chr11

61135395

+
intron-intronENST00000460649ENST00000540194FADS1chr11

61580715

-TMEM138chr11

61135395

+
intron-intronENST00000536991ENST00000381787FADS1chr11

61580715

-TMEM138chr11

61135395

+
intron-intronENST00000536991ENST00000540194FADS1chr11

61580715

-TMEM138chr11

61135395

+
intron-intronENST00000541683ENST00000381787FADS1chr11

61580715

-TMEM138chr11

61135395

+
intron-intronENST00000541683ENST00000540194FADS1chr11

61580715

-TMEM138chr11

61135395

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000350997FADS1chr1161580715-ENST00000278826TMEM138chr1161135395+1708719176907243
ENST00000433932FADS1chr1161580715-ENST00000278826TMEM138chr1161135395+1306317143505120

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000350997ENST00000278826FADS1chr1161580715-TMEM138chr1161135395+0.156902280.8430977
ENST00000433932ENST00000278826FADS1chr1161580715-TMEM138chr1161135395+0.385432450.6145676

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Fusion Genomic Features for FADS1-TMEM138


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FADS1chr1161580714-TMEM138chr1161135394+0.0051650960.9948349
FADS1chr1161580714-TMEM138chr1161135394+0.0051650960.9948349

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FADS1-TMEM138


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:61580715/chr11:61135395)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFADS1chr11:61580715chr11:61135395ENST00000350997-21217_94162502.0DomainCytochrome b5 heme-binding
HgeneFADS1chr11:61580715chr11:61135395ENST00000350997-212143_145162502.0Topological domainLumenal
HgeneFADS1chr11:61580715chr11:61135395ENST00000350997-2121_121162502.0Topological domainCytoplasmic
HgeneFADS1chr11:61580715chr11:61135395ENST00000350997-212122_142162502.0TransmembraneHelical
TgeneTMEM138chr11:61580715chr11:61135395ENST0000027882625110_130100163.0TransmembraneHelical
TgeneTMEM138chr11:61580715chr11:61135395ENST0000054294603110_1300106.0TransmembraneHelical
TgeneTMEM138chr11:61580715chr11:61135395ENST000005429460341_610106.0TransmembraneHelical
TgeneTMEM138chr11:61580715chr11:61135395ENST00000542946037_270106.0TransmembraneHelical
TgeneTMEM138chr11:61580715chr11:61135395ENST000005429460380_1000106.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFADS1chr11:61580715chr11:61135395ENST00000433932-21217_9421361.0DomainCytochrome b5 heme-binding
HgeneFADS1chr11:61580715chr11:61135395ENST00000542506-21217_9421361.0DomainCytochrome b5 heme-binding
HgeneFADS1chr11:61580715chr11:61135395ENST00000350997-212179_183162502.0MotifNote=Histidine box-1
HgeneFADS1chr11:61580715chr11:61135395ENST00000350997-212216_220162502.0MotifNote=Histidine box-2
HgeneFADS1chr11:61580715chr11:61135395ENST00000350997-212382_386162502.0MotifNote=Histidine box-3
HgeneFADS1chr11:61580715chr11:61135395ENST00000433932-212179_18321361.0MotifNote=Histidine box-1
HgeneFADS1chr11:61580715chr11:61135395ENST00000433932-212216_22021361.0MotifNote=Histidine box-2
HgeneFADS1chr11:61580715chr11:61135395ENST00000433932-212382_38621361.0MotifNote=Histidine box-3
HgeneFADS1chr11:61580715chr11:61135395ENST00000542506-212179_18321361.0MotifNote=Histidine box-1
HgeneFADS1chr11:61580715chr11:61135395ENST00000542506-212216_22021361.0MotifNote=Histidine box-2
HgeneFADS1chr11:61580715chr11:61135395ENST00000542506-212382_38621361.0MotifNote=Histidine box-3
HgeneFADS1chr11:61580715chr11:61135395ENST00000350997-212171_267162502.0Topological domainCytoplasmic
HgeneFADS1chr11:61580715chr11:61135395ENST00000350997-212289_305162502.0Topological domainLumenal
HgeneFADS1chr11:61580715chr11:61135395ENST00000350997-212327_444162502.0Topological domainCytoplasmic
HgeneFADS1chr11:61580715chr11:61135395ENST00000433932-212143_14521361.0Topological domainLumenal
HgeneFADS1chr11:61580715chr11:61135395ENST00000433932-212171_26721361.0Topological domainCytoplasmic
HgeneFADS1chr11:61580715chr11:61135395ENST00000433932-2121_12121361.0Topological domainCytoplasmic
HgeneFADS1chr11:61580715chr11:61135395ENST00000433932-212289_30521361.0Topological domainLumenal
HgeneFADS1chr11:61580715chr11:61135395ENST00000433932-212327_44421361.0Topological domainCytoplasmic
HgeneFADS1chr11:61580715chr11:61135395ENST00000542506-212143_14521361.0Topological domainLumenal
HgeneFADS1chr11:61580715chr11:61135395ENST00000542506-212171_26721361.0Topological domainCytoplasmic
HgeneFADS1chr11:61580715chr11:61135395ENST00000542506-2121_12121361.0Topological domainCytoplasmic
HgeneFADS1chr11:61580715chr11:61135395ENST00000542506-212289_30521361.0Topological domainLumenal
HgeneFADS1chr11:61580715chr11:61135395ENST00000542506-212327_44421361.0Topological domainCytoplasmic
HgeneFADS1chr11:61580715chr11:61135395ENST00000350997-212146_170162502.0TransmembraneHelical
HgeneFADS1chr11:61580715chr11:61135395ENST00000350997-212268_288162502.0TransmembraneHelical
HgeneFADS1chr11:61580715chr11:61135395ENST00000350997-212306_326162502.0TransmembraneHelical
HgeneFADS1chr11:61580715chr11:61135395ENST00000433932-212122_14221361.0TransmembraneHelical
HgeneFADS1chr11:61580715chr11:61135395ENST00000433932-212146_17021361.0TransmembraneHelical
HgeneFADS1chr11:61580715chr11:61135395ENST00000433932-212268_28821361.0TransmembraneHelical
HgeneFADS1chr11:61580715chr11:61135395ENST00000433932-212306_32621361.0TransmembraneHelical
HgeneFADS1chr11:61580715chr11:61135395ENST00000542506-212122_14221361.0TransmembraneHelical
HgeneFADS1chr11:61580715chr11:61135395ENST00000542506-212146_17021361.0TransmembraneHelical
HgeneFADS1chr11:61580715chr11:61135395ENST00000542506-212268_28821361.0TransmembraneHelical
HgeneFADS1chr11:61580715chr11:61135395ENST00000542506-212306_32621361.0TransmembraneHelical
TgeneTMEM138chr11:61580715chr11:61135395ENST000002788262541_61100163.0TransmembraneHelical
TgeneTMEM138chr11:61580715chr11:61135395ENST00000278826257_27100163.0TransmembraneHelical
TgeneTMEM138chr11:61580715chr11:61135395ENST000002788262580_100100163.0TransmembraneHelical


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Fusion Gene Sequence for FADS1-TMEM138


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28217_28217_1_FADS1-TMEM138_FADS1_chr11_61580715_ENST00000350997_TMEM138_chr11_61135395_ENST00000278826_length(transcript)=1708nt_BP=719nt
CATTCACTCCTGCAGCGCGGCCCCGCACCCAGGGCCTGCACTAGAACCGCTGTTCCTACCGCGGCGCCCCCTGGGAGCCAACGCCGCGAT
GCCCGCCTGACGTCAGGAAGTCGAATCCGGCGGCGACGCCTTTAGGGAGCCCGCGAGGGGGCGCGTGTTGGCAGCCCAGCTGTGAGTTGC
CCAAGACCCACCGGGGGACGGGATCTCGCTCCCCGCGCCACGAGGCTCGGCCAATGGGAACGCGCGCTGCGAGGCCCGCCGGTCTGCCCT
GCGGTGCTGAAAACCCGGCGCGCAGGCGGCTGGCTCTGGGCGCGCGCCAGCAAATCCACTCCTGGAGCCCGCGGACCCCGAGCACGCGCC
TGACAGCCCCTGCTGGCCCGGCGCGCGGCGTCGCCAGGCCAGCTATGGCCCCCGACCCGGTGGCCGCCGAGACCGCGGCTCAGGGACCTA
CCCCGCGCTACTTCACCTGGGACGAGGTGGCCCAGCGCTCAGGGTGCGAGGAGCGGTGGCTAGTGATCGACCGTAAGGTGTACAACATCA
GCGAGTTCACCCGCCGGCATCCAGGGGGCTCCCGGGTCATCAGCCACTACGCCGGGCAGGATGCCACGGATCCCTTTGTGGCCTTCCACA
TCAACAAGGGCCTTGTGAAGAAGTATATGAACTCTCTCCTGATTGGAGAACTGTCTCCAGAGCAGCCCAGCTTTGAGCCCACCAAGAATA
ACTTACGCTGGAAAAACTCCAACAGCTTCATATGGACAGATGGACTTCAAATGCTGTTTGTATTCCAGAGACTAGCAGCAGTGTTGTACT
GCTACTTCTATAAACGGACAGCCGTAAGACTAGGCGATCCTCACTTCTACCAGGACTCTTTGTGGCTGCGCAAGGAGTTCATGCAAGTTC
GAAGGTGACCTCTTGTCACACTGATGGATACTTTTCCTTCCTGATAGAAGCCACATTTGCTGCTTTGCAGGGAGAGTTGGCCCTATGCAT
GGGCAAACAGCTGGACTTTCCAAGGAAGGTTCAGACTAGCTGTGTTCAGCATTCAAGAAGGAAGATCCTCCCTCTTGCACAATTAGAGTG
TCCCCATCGGTCTCCAGTGCGGCATCCCTTCCTTGCCTTCTACCTCTGTTCCACCCCCTTTCCTTCCTTTCCTCTCTGTACCATTCATTC
TCCCTGACCGGCCTTTCTTGCCGAGGGTTCTGTGGCTCTTACCCTTGTGAAGCTTTTCCTTTAGCCTGGGACAGAAGGACCTCCCAGCCC
CCAAAGGATCTCCCAGTGACCAAAGGATGCGAAGAGTGATAGTTACGTGCTCCTGACTGATCACACCGCAGACATTTAGATTTTTATACC
CAAGGCACTTTAAAAAAATGTTTTATAAATAGAGAATAAATTGAATTCTTGTTCCATAAATGGGGGAGTCTGTCTGTCTAGCTAGATCTC
TTCATGTTAAGAGGCGTGCCAAGGTCCAGCTTAACATCTACTTGACCCAGAGGGAAGATGGAGCCACAGATGAAATACAGATCTTTGTTG
AGATCCATTATGAGTACAAAGTATTTTAGCAGAAATTCAAGATGGAATCTGATGCTGCATCCCCCACTCCTGGAGCTCCAGATGTGTGTG

>28217_28217_1_FADS1-TMEM138_FADS1_chr11_61580715_ENST00000350997_TMEM138_chr11_61135395_ENST00000278826_length(amino acids)=243AA_BP=181
MPKTHRGTGSRSPRHEARPMGTRAARPAGLPCGAENPARRRLALGARQQIHSWSPRTPSTRLTAPAGPARGVARPAMAPDPVAAETAAQG
PTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVISHYAGQDATDPFVAFHINKGLVKKYMNSLLIGELSPEQPSFEPTK

--------------------------------------------------------------
>28217_28217_2_FADS1-TMEM138_FADS1_chr11_61580715_ENST00000433932_TMEM138_chr11_61135395_ENST00000278826_length(transcript)=1306nt_BP=317nt
GTCTCGATGGCTAGGAGAGGCAGCGCAGCCGCGTCTGGACCTAGGTGCCGGTCTCCACTCGCCAGCAGGAGCGGAGAGGGAGCAGGAAAG
GAGCCCATTCTCGAGGATGGGGCTGAAACGGGAAGCTTGGGGAGACCGCTGCCTTGGGGACCCCTGCGTCGTGTGAAGACTGGAGGACGC
GGAAGGGACAGCGCTGGCCGGGGAGGGATCCCTTTGTGGCCTTCCACATCAACAAGGGCCTTGTGAAGAAGTATATGAACTCTCTCCTGA
TTGGAGAACTGTCTCCAGAGCAGCCCAGCTTTGAGCCCACCAAGAATAACTTACGCTGGAAAAACTCCAACAGCTTCATATGGACAGATG
GACTTCAAATGCTGTTTGTATTCCAGAGACTAGCAGCAGTGTTGTACTGCTACTTCTATAAACGGACAGCCGTAAGACTAGGCGATCCTC
ACTTCTACCAGGACTCTTTGTGGCTGCGCAAGGAGTTCATGCAAGTTCGAAGGTGACCTCTTGTCACACTGATGGATACTTTTCCTTCCT
GATAGAAGCCACATTTGCTGCTTTGCAGGGAGAGTTGGCCCTATGCATGGGCAAACAGCTGGACTTTCCAAGGAAGGTTCAGACTAGCTG
TGTTCAGCATTCAAGAAGGAAGATCCTCCCTCTTGCACAATTAGAGTGTCCCCATCGGTCTCCAGTGCGGCATCCCTTCCTTGCCTTCTA
CCTCTGTTCCACCCCCTTTCCTTCCTTTCCTCTCTGTACCATTCATTCTCCCTGACCGGCCTTTCTTGCCGAGGGTTCTGTGGCTCTTAC
CCTTGTGAAGCTTTTCCTTTAGCCTGGGACAGAAGGACCTCCCAGCCCCCAAAGGATCTCCCAGTGACCAAAGGATGCGAAGAGTGATAG
TTACGTGCTCCTGACTGATCACACCGCAGACATTTAGATTTTTATACCCAAGGCACTTTAAAAAAATGTTTTATAAATAGAGAATAAATT
GAATTCTTGTTCCATAAATGGGGGAGTCTGTCTGTCTAGCTAGATCTCTTCATGTTAAGAGGCGTGCCAAGGTCCAGCTTAACATCTACT
TGACCCAGAGGGAAGATGGAGCCACAGATGAAATACAGATCTTTGTTGAGATCCATTATGAGTACAAAGTATTTTAGCAGAAATTCAAGA
TGGAATCTGATGCTGCATCCCCCACTCCTGGAGCTCCAGATGTGTGTGCTCTGTTCAGACTCTCTTTCCTTATCAGAAGCCTTAACTGCC

>28217_28217_2_FADS1-TMEM138_FADS1_chr11_61580715_ENST00000433932_TMEM138_chr11_61135395_ENST00000278826_length(amino acids)=120AA_BP=58
MGTPASCEDWRTRKGQRWPGRDPFVAFHINKGLVKKYMNSLLIGELSPEQPSFEPTKNNLRWKNSNSFIWTDGLQMLFVFQRLAAVLYCY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FADS1-TMEM138


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FADS1-TMEM138


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FADS1-TMEM138


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFADS1C0009402Colorectal Carcinoma1CTD_human
HgeneFADS1C0009404Colorectal Neoplasms1CTD_human
HgeneFADS1C0019193Hepatitis, Toxic1CTD_human
HgeneFADS1C0024623Malignant neoplasm of stomach1CTD_human
HgeneFADS1C0038356Stomach Neoplasms1CTD_human
HgeneFADS1C0860207Drug-Induced Liver Disease1CTD_human
HgeneFADS1C1262760Hepatitis, Drug-Induced1CTD_human
HgeneFADS1C1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneFADS1C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneFADS1C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneFADS1C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneC0431399Familial aplasia of the vermis1GENOMICS_ENGLAND
TgeneC1855675Arima syndrome1GENOMICS_ENGLAND;ORPHANET
TgeneC3280906JOUBERT SYNDROME 161GENOMICS_ENGLAND;UNIPROT