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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM190A-SPARCL1 (FusionGDB2 ID:HG401145TG8404)

Fusion Gene Summary for FAM190A-SPARCL1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM190A-SPARCL1
Fusion gene ID: hg401145tg8404
HgeneTgene
Gene symbol

FAM190A

SPARCL1

Gene ID

401145

8404

Gene namecoiled-coil serine rich protein 1SPARC like 1
SynonymsFAM190AMAST 9|MAST9|PIG33|SC1
Cytomap('CCSER1','FAM190A')('SPARCL1','SPARCL1')

4q22.1

4q22.1

Type of geneprotein-codingprotein-coding
Descriptionserine-rich coiled-coil domain-containing protein 1family with sequence similarity 190, member Aprotein FAM190ASPARC-like protein 1SPARC-like 1 (hevin)high endothelial venule proteinproliferation-inducing protein 33
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000333691, ENST00000432775, 
ENST00000509176, ENST00000504150, 
Fusion gene scores* DoF score16 X 13 X 7=145614 X 14 X 5=980
# samples 1817
** MAII scorelog2(18/1456*10)=-3.01594154386902
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/980*10)=-2.52724700286487
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM190A [Title/Abstract] AND SPARCL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCSER1(91389505)-SPARCL1(88394955), # samples:2
FAM190A(91389505)-SPARCL1(88394955), # samples:2
Anticipated loss of major functional domain due to fusion event.CCSER1-SPARCL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCSER1-SPARCL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCSER1-SPARCL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CCSER1-SPARCL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CCSER1-SPARCL1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CCSER1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SPARCL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-AA68-01ACCSER1chr4

91389505

+SPARCL1chr4

88394955

-
ChimerDB4STADTCGA-VQ-AA68-01AFAM190Achr4

91389505

-SPARCL1chr4

88394955

-
ChimerDB4STADTCGA-VQ-AA68FAM190Achr4

91389505

+SPARCL1chr4

88394955

-


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Fusion Gene ORF analysis for FAM190A-SPARCL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000333691ENST00000282470CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
Frame-shiftENST00000432775ENST00000282470CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
Frame-shiftENST00000509176ENST00000282470CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
In-frameENST00000333691ENST00000418378CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
In-frameENST00000333691ENST00000503414CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
In-frameENST00000432775ENST00000418378CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
In-frameENST00000432775ENST00000503414CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
In-frameENST00000509176ENST00000418378CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
In-frameENST00000509176ENST00000503414CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
intron-3CDSENST00000504150ENST00000282470CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
intron-3CDSENST00000504150ENST00000418378CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
intron-3CDSENST00000504150ENST00000503414CCSER1chr4

91389505

+SPARCL1chr4

88394955

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000509176CCSER1chr491389505+ENST00000418378SPARCL1chr488394955-246820122882024578
ENST00000509176CCSER1chr491389505+ENST00000503414SPARCL1chr488394955-239820122882024578
ENST00000333691CCSER1chr491389505+ENST00000418378SPARCL1chr488394955-253420783542090578
ENST00000333691CCSER1chr491389505+ENST00000503414SPARCL1chr488394955-246420783542090578
ENST00000432775CCSER1chr491389505+ENST00000418378SPARCL1chr488394955-253420783542090578
ENST00000432775CCSER1chr491389505+ENST00000503414SPARCL1chr488394955-246420783542090578

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000509176ENST00000418378CCSER1chr491389505+SPARCL1chr488394955-0.001009320.9989907
ENST00000509176ENST00000503414CCSER1chr491389505+SPARCL1chr488394955-0.0013481580.9986519
ENST00000333691ENST00000418378CCSER1chr491389505+SPARCL1chr488394955-0.0010817960.9989182
ENST00000333691ENST00000503414CCSER1chr491389505+SPARCL1chr488394955-0.0013852480.9986148
ENST00000432775ENST00000418378CCSER1chr491389505+SPARCL1chr488394955-0.0010817960.9989182
ENST00000432775ENST00000503414CCSER1chr491389505+SPARCL1chr488394955-0.0013852480.9986148

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Fusion Genomic Features for FAM190A-SPARCL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FAM190A-SPARCL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:91389505/:88394955)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCSER1chr4:91389505chr4:88394955ENST00000333691+511495_498574901.0Compositional biasNote=Poly-Ser
HgeneCCSER1chr4:91389505chr4:88394955ENST00000333691+5114_69574901.0Compositional biasNote=Ser-rich
HgeneCCSER1chr4:91389505chr4:88394955ENST00000432775+58495_498574678.0Compositional biasNote=Poly-Ser
HgeneCCSER1chr4:91389505chr4:88394955ENST00000432775+584_69574678.0Compositional biasNote=Ser-rich
HgeneCCSER1chr4:91389505chr4:88394955ENST00000509176+511495_498574901.0Compositional biasNote=Poly-Ser
HgeneCCSER1chr4:91389505chr4:88394955ENST00000509176+5114_69574901.0Compositional biasNote=Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCSER1chr4:91389505chr4:88394955ENST00000333691+511673_707574901.0Coiled coilOntology_term=ECO:0000255
HgeneCCSER1chr4:91389505chr4:88394955ENST00000432775+58673_707574678.0Coiled coilOntology_term=ECO:0000255
HgeneCCSER1chr4:91389505chr4:88394955ENST00000509176+511673_707574901.0Coiled coilOntology_term=ECO:0000255
TgeneSPARCL1chr4:91389505chr4:88394955ENST00000282470911635_646655665.0Calcium bindingOntology_term=ECO:0000255
TgeneSPARCL1chr4:91389505chr4:88394955ENST000004183781012635_646655665.0Calcium bindingOntology_term=ECO:0000255
TgeneSPARCL1chr4:91389505chr4:88394955ENST00000282470911432_454655665.0DomainNote=Follistatin-like
TgeneSPARCL1chr4:91389505chr4:88394955ENST00000282470911450_511655665.0DomainKazal-like
TgeneSPARCL1chr4:91389505chr4:88394955ENST00000282470911622_657655665.0DomainEF-hand
TgeneSPARCL1chr4:91389505chr4:88394955ENST000004183781012432_454655665.0DomainNote=Follistatin-like
TgeneSPARCL1chr4:91389505chr4:88394955ENST000004183781012450_511655665.0DomainKazal-like
TgeneSPARCL1chr4:91389505chr4:88394955ENST000004183781012622_657655665.0DomainEF-hand
TgeneSPARCL1chr4:91389505chr4:88394955ENST0000028247091125_34655665.0RegionNote=O-glycosylated at one additional site
TgeneSPARCL1chr4:91389505chr4:88394955ENST00000418378101225_34655665.0RegionNote=O-glycosylated at one additional site


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Fusion Gene Sequence for FAM190A-SPARCL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14262_14262_1_CCSER1-SPARCL1_CCSER1_chr4_91389505_ENST00000333691_SPARCL1_chr4_88394955_ENST00000418378_length(transcript)=2534nt_BP=2078nt
GTTACCATCGAGACCGGGGCTGTGTATGCTCGAGGTGCAGGGAGCTAATGTATAAGGAGTTAAATGAACTCTTGCTGCTGCCAAATATGT
TGTTATCACTAACTGCACCGCTGCTGTCATTAGTGCTGCTGCCAACACTGCAAGCCCTGCTGCTGCCAGTGCCAATTCTGCTGATGCCTT
GGGCTCTCCATGTCCCAGGGTGATTCCATAGACAAGCAGCTGCTTTTAGATTTCACTTGCTCATTACCTGTAGATCCTTTGCCTTAGGAC
TCAAGCTTAAGCCCATGAAGCCTGGGATAGAAGACAATTGGAGGCTGCAAAGTTGGCTTTCACAGTGCAAGCCTTTGATTCCCAATGGGG
GACTCAGGATCAAGACGATCTACCCTGGTCTCCCGGTTGCCAATATTCAGAAGAAGTATTAACAGAAGACATGATTCTCTTCCTTCTTCA
CCTTCTTCCAGTAATACAGTTGGTGTCCACAGTTCCTCTCCTTCCAGCACTAACTCAAGCTCAGGTAGCACAGGTAAACGGAGGAGCATA
TTCCGTACTCCTTCCATTAGCTTCCACCATAAGAAGGGGAGTGAGCCTAAGCAAGAGCCTACCAACCAGAACCTTAGTATTTCAAATGGT
GCTCAACCTGGTCACAGCAATATGCAGAAACTGAGTTTGGAAGAACATATTAAGACCAGGGGAAGACATTCTGTTGGTTTTAGTAGTTCA
CGAAATAAGAAGATAACAAGATCTTTGACAGAGGATTTTGAAAGGGAAAAAGAGCACTCAACTAACAAGAATGTCTTTATAAATTGTCTA
AGTTCTGGCAAAAGTGAAGGGGATGATTCTGGTTTCACAGAAGACCAAACTCGTCGTTCTGTTAAGCAGTCAACAAGGAAGCTACTCCCT
AAATCTTTTTCATCTCACTATAAATTTTCTAAGCCAGTTCTACAGAGCCAATCCATTTCATTGGTACAACAGTCTGAATTCTCATTGGAA
GTTACACAGTACCAAGAGAGAGAACCTGTATTAGTAAGAGCTTCGCCATCCTGTTCTGTGGATGTAACAGAACGGGCAGGAAGCTCTTTA
CAATCTCCTTTGCTTTCTGCTGATCTTACCACAGCTCAGACACCTTCAGAATTTTTAGCCTTGACTGAAGATTCTGTGTCTGAAATGGAT
GCATTTTCTAAAAGTGGAAGCATGGCATCCCACTGTGACAACTTTGGCCACAATGATTCTACCTCTCAGATGTCCCTCAATTCTGCTGCT
GTTACAAAGACAACAACAGAACTTACGGGAACTGTTCCCTGTGCAATTATGTCTCCTGGGAAATATAGGTTAGAGGGTCAATGTAGCACT
GAATCTAATTCATTACCGGAAACCTCTGCTGCTAATCAGAAGGAAGTGTTATTACAAATTGCTGAACTACCTGCTACAAGTGTGAGCCAC
TCAGAGAGTAACCTACCAGCAGATAGTGAAAGAGAAGAAAATATAGGGTTACAAAATGGTGAAACAATGCTGGGGACAAACTCCCCAAGG
AAACTTGGATTTTATGAGCAACATAAAGCAATAGCGGAACATGTAAAAGGGATCCATCCTATTTCAGATTCAAAGATAATACCTACTTCT
GGTGATCATCATATTTTTAACAAAACATCACATGGATATGAAGCAAATCCTGCCAAAGTTCTTGCCAGTAGTCTCAGTCCATTTCGTGAA
GGAAGATTTATAGAGAGGAGACTGCGATCCTCGTCAGAAGGCACTGCAGGGAGTAGCAGAATGATTTTGAAACCGAAAGATGGAAATATA
GAAGAAGTTAATAGTTTAAGAAAGCAAAGAGCAGGTTCTTCATCTTCAAAAATGAACAGTTTGGATGTTTTGAATAATTTGGGATCTTGT
GAACTGGATGAAGATGATCTAATGCTTGATCTTGAATTTTTAGAGGAACAGAGTCTTCACCCTTCTGTTTGCCGGGAGGACTCATATCAC
TCTGTCGTCTCATGTGCCGCAGTAGTTCTTACTCCTATGGAACCAATGATAGAAATGAAGAAAAGAGAAGAACCAGAATTTCCTGAGCCT
TCCAAACAAGGACATAGATGAAAATCTCTTGTTTTGAACGAAGATTTTAAAGAACTCAACTTTCCAGCATCCTCCTCTGTTCTAACCACT
TCAGAAATATATGCAGCTGTGATACTTGTAGATTTATATTTAGCAAAATGTTAGCATGTATGACAAGACAATGAGAGTAATTGCTTGACA
ACAACCTATGCACCAGGTATTTAACATTAACTTTGGAAACAAAAATGTACAATTAAGTAAAGTCAACATATGCAAAATACTGTACATTGT
GAACAGAAGTTTAATTCATAGTAATTTCACTCTCTGCATTGACTTATGAGATAATTAATGATTAAACTATTAATGATAAAAATAATGCAT
TTGTATTGTTCATAATATCATGTGCACTTCAAGAAAATGGAATGCTACTCTTTTGTGGTTTACGTGTATTATTTTCAATATCTTAATACC
CTAATAAAGAGTCC

>14262_14262_1_CCSER1-SPARCL1_CCSER1_chr4_91389505_ENST00000333691_SPARCL1_chr4_88394955_ENST00000418378_length(amino acids)=578AA_BP=
MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSIS
NGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL
LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSE
MDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV
SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIPTSGDHHIFNKTSHGYEANPAKVLASSLSPF
REGRFIERRLRSSSEGTAGSSRMILKPKDGNIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS
YHSVVSCAAVVLTPMEPMIEMKKREEPEFPEPSKQGHR

--------------------------------------------------------------
>14262_14262_2_CCSER1-SPARCL1_CCSER1_chr4_91389505_ENST00000333691_SPARCL1_chr4_88394955_ENST00000503414_length(transcript)=2464nt_BP=2078nt
GTTACCATCGAGACCGGGGCTGTGTATGCTCGAGGTGCAGGGAGCTAATGTATAAGGAGTTAAATGAACTCTTGCTGCTGCCAAATATGT
TGTTATCACTAACTGCACCGCTGCTGTCATTAGTGCTGCTGCCAACACTGCAAGCCCTGCTGCTGCCAGTGCCAATTCTGCTGATGCCTT
GGGCTCTCCATGTCCCAGGGTGATTCCATAGACAAGCAGCTGCTTTTAGATTTCACTTGCTCATTACCTGTAGATCCTTTGCCTTAGGAC
TCAAGCTTAAGCCCATGAAGCCTGGGATAGAAGACAATTGGAGGCTGCAAAGTTGGCTTTCACAGTGCAAGCCTTTGATTCCCAATGGGG
GACTCAGGATCAAGACGATCTACCCTGGTCTCCCGGTTGCCAATATTCAGAAGAAGTATTAACAGAAGACATGATTCTCTTCCTTCTTCA
CCTTCTTCCAGTAATACAGTTGGTGTCCACAGTTCCTCTCCTTCCAGCACTAACTCAAGCTCAGGTAGCACAGGTAAACGGAGGAGCATA
TTCCGTACTCCTTCCATTAGCTTCCACCATAAGAAGGGGAGTGAGCCTAAGCAAGAGCCTACCAACCAGAACCTTAGTATTTCAAATGGT
GCTCAACCTGGTCACAGCAATATGCAGAAACTGAGTTTGGAAGAACATATTAAGACCAGGGGAAGACATTCTGTTGGTTTTAGTAGTTCA
CGAAATAAGAAGATAACAAGATCTTTGACAGAGGATTTTGAAAGGGAAAAAGAGCACTCAACTAACAAGAATGTCTTTATAAATTGTCTA
AGTTCTGGCAAAAGTGAAGGGGATGATTCTGGTTTCACAGAAGACCAAACTCGTCGTTCTGTTAAGCAGTCAACAAGGAAGCTACTCCCT
AAATCTTTTTCATCTCACTATAAATTTTCTAAGCCAGTTCTACAGAGCCAATCCATTTCATTGGTACAACAGTCTGAATTCTCATTGGAA
GTTACACAGTACCAAGAGAGAGAACCTGTATTAGTAAGAGCTTCGCCATCCTGTTCTGTGGATGTAACAGAACGGGCAGGAAGCTCTTTA
CAATCTCCTTTGCTTTCTGCTGATCTTACCACAGCTCAGACACCTTCAGAATTTTTAGCCTTGACTGAAGATTCTGTGTCTGAAATGGAT
GCATTTTCTAAAAGTGGAAGCATGGCATCCCACTGTGACAACTTTGGCCACAATGATTCTACCTCTCAGATGTCCCTCAATTCTGCTGCT
GTTACAAAGACAACAACAGAACTTACGGGAACTGTTCCCTGTGCAATTATGTCTCCTGGGAAATATAGGTTAGAGGGTCAATGTAGCACT
GAATCTAATTCATTACCGGAAACCTCTGCTGCTAATCAGAAGGAAGTGTTATTACAAATTGCTGAACTACCTGCTACAAGTGTGAGCCAC
TCAGAGAGTAACCTACCAGCAGATAGTGAAAGAGAAGAAAATATAGGGTTACAAAATGGTGAAACAATGCTGGGGACAAACTCCCCAAGG
AAACTTGGATTTTATGAGCAACATAAAGCAATAGCGGAACATGTAAAAGGGATCCATCCTATTTCAGATTCAAAGATAATACCTACTTCT
GGTGATCATCATATTTTTAACAAAACATCACATGGATATGAAGCAAATCCTGCCAAAGTTCTTGCCAGTAGTCTCAGTCCATTTCGTGAA
GGAAGATTTATAGAGAGGAGACTGCGATCCTCGTCAGAAGGCACTGCAGGGAGTAGCAGAATGATTTTGAAACCGAAAGATGGAAATATA
GAAGAAGTTAATAGTTTAAGAAAGCAAAGAGCAGGTTCTTCATCTTCAAAAATGAACAGTTTGGATGTTTTGAATAATTTGGGATCTTGT
GAACTGGATGAAGATGATCTAATGCTTGATCTTGAATTTTTAGAGGAACAGAGTCTTCACCCTTCTGTTTGCCGGGAGGACTCATATCAC
TCTGTCGTCTCATGTGCCGCAGTAGTTCTTACTCCTATGGAACCAATGATAGAAATGAAGAAAAGAGAAGAACCAGAATTTCCTGAGCCT
TCCAAACAAGGACATAGATGAAAATCTCTTGTTTTGAACGAAGATTTTAAAGAACTCAACTTTCCAGCATCCTCCTCTGTTCTAACCACT
TCAGAAATATATGCAGCTGTGATACTTGTAGATTTATATTTAGCAAAATGTTAGCATGTATGACAAGACAATGAGAGTAATTGCTTGACA
ACAACCTATGCACCAGGTATTTAACATTAACTTTGGAAACAAAAATGTACAATTAAGTAAAGTCAACATATGCAAAATACTGTACATTGT
GAACAGAAGTTTAATTCATAGTAATTTCACTCTCTGCATTGACTTATGAGATAATTAATGATTAAACTATTAATGATAAAAATAATGCAT
TTGTATTGTTCATAATATCATGTGCACTTCAAGA

>14262_14262_2_CCSER1-SPARCL1_CCSER1_chr4_91389505_ENST00000333691_SPARCL1_chr4_88394955_ENST00000503414_length(amino acids)=578AA_BP=
MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSIS
NGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL
LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSE
MDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV
SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIPTSGDHHIFNKTSHGYEANPAKVLASSLSPF
REGRFIERRLRSSSEGTAGSSRMILKPKDGNIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS
YHSVVSCAAVVLTPMEPMIEMKKREEPEFPEPSKQGHR

--------------------------------------------------------------
>14262_14262_3_CCSER1-SPARCL1_CCSER1_chr4_91389505_ENST00000432775_SPARCL1_chr4_88394955_ENST00000418378_length(transcript)=2534nt_BP=2078nt
GTTACCATCGAGACCGGGGCTGTGTATGCTCGAGGTGCAGGGAGCTAATGTATAAGGAGTTAAATGAACTCTTGCTGCTGCCAAATATGT
TGTTATCACTAACTGCACCGCTGCTGTCATTAGTGCTGCTGCCAACACTGCAAGCCCTGCTGCTGCCAGTGCCAATTCTGCTGATGCCTT
GGGCTCTCCATGTCCCAGGGTGATTCCATAGACAAGCAGCTGCTTTTAGATTTCACTTGCTCATTACCTGTAGATCCTTTGCCTTAGGAC
TCAAGCTTAAGCCCATGAAGCCTGGGATAGAAGACAATTGGAGGCTGCAAAGTTGGCTTTCACAGTGCAAGCCTTTGATTCCCAATGGGG
GACTCAGGATCAAGACGATCTACCCTGGTCTCCCGGTTGCCAATATTCAGAAGAAGTATTAACAGAAGACATGATTCTCTTCCTTCTTCA
CCTTCTTCCAGTAATACAGTTGGTGTCCACAGTTCCTCTCCTTCCAGCACTAACTCAAGCTCAGGTAGCACAGGTAAACGGAGGAGCATA
TTCCGTACTCCTTCCATTAGCTTCCACCATAAGAAGGGGAGTGAGCCTAAGCAAGAGCCTACCAACCAGAACCTTAGTATTTCAAATGGT
GCTCAACCTGGTCACAGCAATATGCAGAAACTGAGTTTGGAAGAACATATTAAGACCAGGGGAAGACATTCTGTTGGTTTTAGTAGTTCA
CGAAATAAGAAGATAACAAGATCTTTGACAGAGGATTTTGAAAGGGAAAAAGAGCACTCAACTAACAAGAATGTCTTTATAAATTGTCTA
AGTTCTGGCAAAAGTGAAGGGGATGATTCTGGTTTCACAGAAGACCAAACTCGTCGTTCTGTTAAGCAGTCAACAAGGAAGCTACTCCCT
AAATCTTTTTCATCTCACTATAAATTTTCTAAGCCAGTTCTACAGAGCCAATCCATTTCATTGGTACAACAGTCTGAATTCTCATTGGAA
GTTACACAGTACCAAGAGAGAGAACCTGTATTAGTAAGAGCTTCGCCATCCTGTTCTGTGGATGTAACAGAACGGGCAGGAAGCTCTTTA
CAATCTCCTTTGCTTTCTGCTGATCTTACCACAGCTCAGACACCTTCAGAATTTTTAGCCTTGACTGAAGATTCTGTGTCTGAAATGGAT
GCATTTTCTAAAAGTGGAAGCATGGCATCCCACTGTGACAACTTTGGCCACAATGATTCTACCTCTCAGATGTCCCTCAATTCTGCTGCT
GTTACAAAGACAACAACAGAACTTACGGGAACTGTTCCCTGTGCAATTATGTCTCCTGGGAAATATAGGTTAGAGGGTCAATGTAGCACT
GAATCTAATTCATTACCGGAAACCTCTGCTGCTAATCAGAAGGAAGTGTTATTACAAATTGCTGAACTACCTGCTACAAGTGTGAGCCAC
TCAGAGAGTAACCTACCAGCAGATAGTGAAAGAGAAGAAAATATAGGGTTACAAAATGGTGAAACAATGCTGGGGACAAACTCCCCAAGG
AAACTTGGATTTTATGAGCAACATAAAGCAATAGCGGAACATGTAAAAGGGATCCATCCTATTTCAGATTCAAAGATAATACCTACTTCT
GGTGATCATCATATTTTTAACAAAACATCACATGGATATGAAGCAAATCCTGCCAAAGTTCTTGCCAGTAGTCTCAGTCCATTTCGTGAA
GGAAGATTTATAGAGAGGAGACTGCGATCCTCGTCAGAAGGCACTGCAGGGAGTAGCAGAATGATTTTGAAACCGAAAGATGGAAATATA
GAAGAAGTTAATAGTTTAAGAAAGCAAAGAGCAGGTTCTTCATCTTCAAAAATGAACAGTTTGGATGTTTTGAATAATTTGGGATCTTGT
GAACTGGATGAAGATGATCTAATGCTTGATCTTGAATTTTTAGAGGAACAGAGTCTTCACCCTTCTGTTTGCCGGGAGGACTCATATCAC
TCTGTCGTCTCATGTGCCGCAGTAGTTCTTACTCCTATGGAACCAATGATAGAAATGAAGAAAAGAGAAGAACCAGAATTTCCTGAGCCT
TCCAAACAAGGACATAGATGAAAATCTCTTGTTTTGAACGAAGATTTTAAAGAACTCAACTTTCCAGCATCCTCCTCTGTTCTAACCACT
TCAGAAATATATGCAGCTGTGATACTTGTAGATTTATATTTAGCAAAATGTTAGCATGTATGACAAGACAATGAGAGTAATTGCTTGACA
ACAACCTATGCACCAGGTATTTAACATTAACTTTGGAAACAAAAATGTACAATTAAGTAAAGTCAACATATGCAAAATACTGTACATTGT
GAACAGAAGTTTAATTCATAGTAATTTCACTCTCTGCATTGACTTATGAGATAATTAATGATTAAACTATTAATGATAAAAATAATGCAT
TTGTATTGTTCATAATATCATGTGCACTTCAAGAAAATGGAATGCTACTCTTTTGTGGTTTACGTGTATTATTTTCAATATCTTAATACC
CTAATAAAGAGTCC

>14262_14262_3_CCSER1-SPARCL1_CCSER1_chr4_91389505_ENST00000432775_SPARCL1_chr4_88394955_ENST00000418378_length(amino acids)=578AA_BP=
MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSIS
NGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL
LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSE
MDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV
SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIPTSGDHHIFNKTSHGYEANPAKVLASSLSPF
REGRFIERRLRSSSEGTAGSSRMILKPKDGNIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS
YHSVVSCAAVVLTPMEPMIEMKKREEPEFPEPSKQGHR

--------------------------------------------------------------
>14262_14262_4_CCSER1-SPARCL1_CCSER1_chr4_91389505_ENST00000432775_SPARCL1_chr4_88394955_ENST00000503414_length(transcript)=2464nt_BP=2078nt
GTTACCATCGAGACCGGGGCTGTGTATGCTCGAGGTGCAGGGAGCTAATGTATAAGGAGTTAAATGAACTCTTGCTGCTGCCAAATATGT
TGTTATCACTAACTGCACCGCTGCTGTCATTAGTGCTGCTGCCAACACTGCAAGCCCTGCTGCTGCCAGTGCCAATTCTGCTGATGCCTT
GGGCTCTCCATGTCCCAGGGTGATTCCATAGACAAGCAGCTGCTTTTAGATTTCACTTGCTCATTACCTGTAGATCCTTTGCCTTAGGAC
TCAAGCTTAAGCCCATGAAGCCTGGGATAGAAGACAATTGGAGGCTGCAAAGTTGGCTTTCACAGTGCAAGCCTTTGATTCCCAATGGGG
GACTCAGGATCAAGACGATCTACCCTGGTCTCCCGGTTGCCAATATTCAGAAGAAGTATTAACAGAAGACATGATTCTCTTCCTTCTTCA
CCTTCTTCCAGTAATACAGTTGGTGTCCACAGTTCCTCTCCTTCCAGCACTAACTCAAGCTCAGGTAGCACAGGTAAACGGAGGAGCATA
TTCCGTACTCCTTCCATTAGCTTCCACCATAAGAAGGGGAGTGAGCCTAAGCAAGAGCCTACCAACCAGAACCTTAGTATTTCAAATGGT
GCTCAACCTGGTCACAGCAATATGCAGAAACTGAGTTTGGAAGAACATATTAAGACCAGGGGAAGACATTCTGTTGGTTTTAGTAGTTCA
CGAAATAAGAAGATAACAAGATCTTTGACAGAGGATTTTGAAAGGGAAAAAGAGCACTCAACTAACAAGAATGTCTTTATAAATTGTCTA
AGTTCTGGCAAAAGTGAAGGGGATGATTCTGGTTTCACAGAAGACCAAACTCGTCGTTCTGTTAAGCAGTCAACAAGGAAGCTACTCCCT
AAATCTTTTTCATCTCACTATAAATTTTCTAAGCCAGTTCTACAGAGCCAATCCATTTCATTGGTACAACAGTCTGAATTCTCATTGGAA
GTTACACAGTACCAAGAGAGAGAACCTGTATTAGTAAGAGCTTCGCCATCCTGTTCTGTGGATGTAACAGAACGGGCAGGAAGCTCTTTA
CAATCTCCTTTGCTTTCTGCTGATCTTACCACAGCTCAGACACCTTCAGAATTTTTAGCCTTGACTGAAGATTCTGTGTCTGAAATGGAT
GCATTTTCTAAAAGTGGAAGCATGGCATCCCACTGTGACAACTTTGGCCACAATGATTCTACCTCTCAGATGTCCCTCAATTCTGCTGCT
GTTACAAAGACAACAACAGAACTTACGGGAACTGTTCCCTGTGCAATTATGTCTCCTGGGAAATATAGGTTAGAGGGTCAATGTAGCACT
GAATCTAATTCATTACCGGAAACCTCTGCTGCTAATCAGAAGGAAGTGTTATTACAAATTGCTGAACTACCTGCTACAAGTGTGAGCCAC
TCAGAGAGTAACCTACCAGCAGATAGTGAAAGAGAAGAAAATATAGGGTTACAAAATGGTGAAACAATGCTGGGGACAAACTCCCCAAGG
AAACTTGGATTTTATGAGCAACATAAAGCAATAGCGGAACATGTAAAAGGGATCCATCCTATTTCAGATTCAAAGATAATACCTACTTCT
GGTGATCATCATATTTTTAACAAAACATCACATGGATATGAAGCAAATCCTGCCAAAGTTCTTGCCAGTAGTCTCAGTCCATTTCGTGAA
GGAAGATTTATAGAGAGGAGACTGCGATCCTCGTCAGAAGGCACTGCAGGGAGTAGCAGAATGATTTTGAAACCGAAAGATGGAAATATA
GAAGAAGTTAATAGTTTAAGAAAGCAAAGAGCAGGTTCTTCATCTTCAAAAATGAACAGTTTGGATGTTTTGAATAATTTGGGATCTTGT
GAACTGGATGAAGATGATCTAATGCTTGATCTTGAATTTTTAGAGGAACAGAGTCTTCACCCTTCTGTTTGCCGGGAGGACTCATATCAC
TCTGTCGTCTCATGTGCCGCAGTAGTTCTTACTCCTATGGAACCAATGATAGAAATGAAGAAAAGAGAAGAACCAGAATTTCCTGAGCCT
TCCAAACAAGGACATAGATGAAAATCTCTTGTTTTGAACGAAGATTTTAAAGAACTCAACTTTCCAGCATCCTCCTCTGTTCTAACCACT
TCAGAAATATATGCAGCTGTGATACTTGTAGATTTATATTTAGCAAAATGTTAGCATGTATGACAAGACAATGAGAGTAATTGCTTGACA
ACAACCTATGCACCAGGTATTTAACATTAACTTTGGAAACAAAAATGTACAATTAAGTAAAGTCAACATATGCAAAATACTGTACATTGT
GAACAGAAGTTTAATTCATAGTAATTTCACTCTCTGCATTGACTTATGAGATAATTAATGATTAAACTATTAATGATAAAAATAATGCAT
TTGTATTGTTCATAATATCATGTGCACTTCAAGA

>14262_14262_4_CCSER1-SPARCL1_CCSER1_chr4_91389505_ENST00000432775_SPARCL1_chr4_88394955_ENST00000503414_length(amino acids)=578AA_BP=
MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSIS
NGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL
LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSE
MDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV
SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIPTSGDHHIFNKTSHGYEANPAKVLASSLSPF
REGRFIERRLRSSSEGTAGSSRMILKPKDGNIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS
YHSVVSCAAVVLTPMEPMIEMKKREEPEFPEPSKQGHR

--------------------------------------------------------------
>14262_14262_5_CCSER1-SPARCL1_CCSER1_chr4_91389505_ENST00000509176_SPARCL1_chr4_88394955_ENST00000418378_length(transcript)=2468nt_BP=2012nt
GTCTCAACATGACTGACTGGGAAGCGGTGGCTCGGGCAGAGCAGCTCCGCTGGCGCAGGCAGGAGGAGCAGGAGGATTATTAAATAACGC
AGCTGGACTCTGTGCAACTGGGAGTGGAGAGGAGCCCAACAGCCGAGAAGGGGAGGGAGGGCAGAGGAGGGGGACCAGGAAGGACACCCC
CGTGCCCCGAAGACATAAATCCCTGAGTGCCCGGGAGGAGCCTTAACAAGCGCACGGAGCCCTCAAGGCTGCAAAGTTGGCTTTCACAGT
GCAAGCCTTTGATTCCCAATGGGGGACTCAGGATCAAGACGATCTACCCTGGTCTCCCGGTTGCCAATATTCAGAAGAAGTATTAACAGA
AGACATGATTCTCTTCCTTCTTCACCTTCTTCCAGTAATACAGTTGGTGTCCACAGTTCCTCTCCTTCCAGCACTAACTCAAGCTCAGGT
AGCACAGGTAAACGGAGGAGCATATTCCGTACTCCTTCCATTAGCTTCCACCATAAGAAGGGGAGTGAGCCTAAGCAAGAGCCTACCAAC
CAGAACCTTAGTATTTCAAATGGTGCTCAACCTGGTCACAGCAATATGCAGAAACTGAGTTTGGAAGAACATATTAAGACCAGGGGAAGA
CATTCTGTTGGTTTTAGTAGTTCACGAAATAAGAAGATAACAAGATCTTTGACAGAGGATTTTGAAAGGGAAAAAGAGCACTCAACTAAC
AAGAATGTCTTTATAAATTGTCTAAGTTCTGGCAAAAGTGAAGGGGATGATTCTGGTTTCACAGAAGACCAAACTCGTCGTTCTGTTAAG
CAGTCAACAAGGAAGCTACTCCCTAAATCTTTTTCATCTCACTATAAATTTTCTAAGCCAGTTCTACAGAGCCAATCCATTTCATTGGTA
CAACAGTCTGAATTCTCATTGGAAGTTACACAGTACCAAGAGAGAGAACCTGTATTAGTAAGAGCTTCGCCATCCTGTTCTGTGGATGTA
ACAGAACGGGCAGGAAGCTCTTTACAATCTCCTTTGCTTTCTGCTGATCTTACCACAGCTCAGACACCTTCAGAATTTTTAGCCTTGACT
GAAGATTCTGTGTCTGAAATGGATGCATTTTCTAAAAGTGGAAGCATGGCATCCCACTGTGACAACTTTGGCCACAATGATTCTACCTCT
CAGATGTCCCTCAATTCTGCTGCTGTTACAAAGACAACAACAGAACTTACGGGAACTGTTCCCTGTGCAATTATGTCTCCTGGGAAATAT
AGGTTAGAGGGTCAATGTAGCACTGAATCTAATTCATTACCGGAAACCTCTGCTGCTAATCAGAAGGAAGTGTTATTACAAATTGCTGAA
CTACCTGCTACAAGTGTGAGCCACTCAGAGAGTAACCTACCAGCAGATAGTGAAAGAGAAGAAAATATAGGGTTACAAAATGGTGAAACA
ATGCTGGGGACAAACTCCCCAAGGAAACTTGGATTTTATGAGCAACATAAAGCAATAGCGGAACATGTAAAAGGGATCCATCCTATTTCA
GATTCAAAGATAATACCTACTTCTGGTGATCATCATATTTTTAACAAAACATCACATGGATATGAAGCAAATCCTGCCAAAGTTCTTGCC
AGTAGTCTCAGTCCATTTCGTGAAGGAAGATTTATAGAGAGGAGACTGCGATCCTCGTCAGAAGGCACTGCAGGGAGTAGCAGAATGATT
TTGAAACCGAAAGATGGAAATATAGAAGAAGTTAATAGTTTAAGAAAGCAAAGAGCAGGTTCTTCATCTTCAAAAATGAACAGTTTGGAT
GTTTTGAATAATTTGGGATCTTGTGAACTGGATGAAGATGATCTAATGCTTGATCTTGAATTTTTAGAGGAACAGAGTCTTCACCCTTCT
GTTTGCCGGGAGGACTCATATCACTCTGTCGTCTCATGTGCCGCAGTAGTTCTTACTCCTATGGAACCAATGATAGAAATGAAGAAAAGA
GAAGAACCAGAATTTCCTGAGCCTTCCAAACAAGGACATAGATGAAAATCTCTTGTTTTGAACGAAGATTTTAAAGAACTCAACTTTCCA
GCATCCTCCTCTGTTCTAACCACTTCAGAAATATATGCAGCTGTGATACTTGTAGATTTATATTTAGCAAAATGTTAGCATGTATGACAA
GACAATGAGAGTAATTGCTTGACAACAACCTATGCACCAGGTATTTAACATTAACTTTGGAAACAAAAATGTACAATTAAGTAAAGTCAA
CATATGCAAAATACTGTACATTGTGAACAGAAGTTTAATTCATAGTAATTTCACTCTCTGCATTGACTTATGAGATAATTAATGATTAAA
CTATTAATGATAAAAATAATGCATTTGTATTGTTCATAATATCATGTGCACTTCAAGAAAATGGAATGCTACTCTTTTGTGGTTTACGTG
TATTATTTTCAATATCTTAATACCCTAATAAAGAGTCC

>14262_14262_5_CCSER1-SPARCL1_CCSER1_chr4_91389505_ENST00000509176_SPARCL1_chr4_88394955_ENST00000418378_length(amino acids)=578AA_BP=
MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSIS
NGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL
LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSE
MDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV
SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIPTSGDHHIFNKTSHGYEANPAKVLASSLSPF
REGRFIERRLRSSSEGTAGSSRMILKPKDGNIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS
YHSVVSCAAVVLTPMEPMIEMKKREEPEFPEPSKQGHR

--------------------------------------------------------------
>14262_14262_6_CCSER1-SPARCL1_CCSER1_chr4_91389505_ENST00000509176_SPARCL1_chr4_88394955_ENST00000503414_length(transcript)=2398nt_BP=2012nt
GTCTCAACATGACTGACTGGGAAGCGGTGGCTCGGGCAGAGCAGCTCCGCTGGCGCAGGCAGGAGGAGCAGGAGGATTATTAAATAACGC
AGCTGGACTCTGTGCAACTGGGAGTGGAGAGGAGCCCAACAGCCGAGAAGGGGAGGGAGGGCAGAGGAGGGGGACCAGGAAGGACACCCC
CGTGCCCCGAAGACATAAATCCCTGAGTGCCCGGGAGGAGCCTTAACAAGCGCACGGAGCCCTCAAGGCTGCAAAGTTGGCTTTCACAGT
GCAAGCCTTTGATTCCCAATGGGGGACTCAGGATCAAGACGATCTACCCTGGTCTCCCGGTTGCCAATATTCAGAAGAAGTATTAACAGA
AGACATGATTCTCTTCCTTCTTCACCTTCTTCCAGTAATACAGTTGGTGTCCACAGTTCCTCTCCTTCCAGCACTAACTCAAGCTCAGGT
AGCACAGGTAAACGGAGGAGCATATTCCGTACTCCTTCCATTAGCTTCCACCATAAGAAGGGGAGTGAGCCTAAGCAAGAGCCTACCAAC
CAGAACCTTAGTATTTCAAATGGTGCTCAACCTGGTCACAGCAATATGCAGAAACTGAGTTTGGAAGAACATATTAAGACCAGGGGAAGA
CATTCTGTTGGTTTTAGTAGTTCACGAAATAAGAAGATAACAAGATCTTTGACAGAGGATTTTGAAAGGGAAAAAGAGCACTCAACTAAC
AAGAATGTCTTTATAAATTGTCTAAGTTCTGGCAAAAGTGAAGGGGATGATTCTGGTTTCACAGAAGACCAAACTCGTCGTTCTGTTAAG
CAGTCAACAAGGAAGCTACTCCCTAAATCTTTTTCATCTCACTATAAATTTTCTAAGCCAGTTCTACAGAGCCAATCCATTTCATTGGTA
CAACAGTCTGAATTCTCATTGGAAGTTACACAGTACCAAGAGAGAGAACCTGTATTAGTAAGAGCTTCGCCATCCTGTTCTGTGGATGTA
ACAGAACGGGCAGGAAGCTCTTTACAATCTCCTTTGCTTTCTGCTGATCTTACCACAGCTCAGACACCTTCAGAATTTTTAGCCTTGACT
GAAGATTCTGTGTCTGAAATGGATGCATTTTCTAAAAGTGGAAGCATGGCATCCCACTGTGACAACTTTGGCCACAATGATTCTACCTCT
CAGATGTCCCTCAATTCTGCTGCTGTTACAAAGACAACAACAGAACTTACGGGAACTGTTCCCTGTGCAATTATGTCTCCTGGGAAATAT
AGGTTAGAGGGTCAATGTAGCACTGAATCTAATTCATTACCGGAAACCTCTGCTGCTAATCAGAAGGAAGTGTTATTACAAATTGCTGAA
CTACCTGCTACAAGTGTGAGCCACTCAGAGAGTAACCTACCAGCAGATAGTGAAAGAGAAGAAAATATAGGGTTACAAAATGGTGAAACA
ATGCTGGGGACAAACTCCCCAAGGAAACTTGGATTTTATGAGCAACATAAAGCAATAGCGGAACATGTAAAAGGGATCCATCCTATTTCA
GATTCAAAGATAATACCTACTTCTGGTGATCATCATATTTTTAACAAAACATCACATGGATATGAAGCAAATCCTGCCAAAGTTCTTGCC
AGTAGTCTCAGTCCATTTCGTGAAGGAAGATTTATAGAGAGGAGACTGCGATCCTCGTCAGAAGGCACTGCAGGGAGTAGCAGAATGATT
TTGAAACCGAAAGATGGAAATATAGAAGAAGTTAATAGTTTAAGAAAGCAAAGAGCAGGTTCTTCATCTTCAAAAATGAACAGTTTGGAT
GTTTTGAATAATTTGGGATCTTGTGAACTGGATGAAGATGATCTAATGCTTGATCTTGAATTTTTAGAGGAACAGAGTCTTCACCCTTCT
GTTTGCCGGGAGGACTCATATCACTCTGTCGTCTCATGTGCCGCAGTAGTTCTTACTCCTATGGAACCAATGATAGAAATGAAGAAAAGA
GAAGAACCAGAATTTCCTGAGCCTTCCAAACAAGGACATAGATGAAAATCTCTTGTTTTGAACGAAGATTTTAAAGAACTCAACTTTCCA
GCATCCTCCTCTGTTCTAACCACTTCAGAAATATATGCAGCTGTGATACTTGTAGATTTATATTTAGCAAAATGTTAGCATGTATGACAA
GACAATGAGAGTAATTGCTTGACAACAACCTATGCACCAGGTATTTAACATTAACTTTGGAAACAAAAATGTACAATTAAGTAAAGTCAA
CATATGCAAAATACTGTACATTGTGAACAGAAGTTTAATTCATAGTAATTTCACTCTCTGCATTGACTTATGAGATAATTAATGATTAAA
CTATTAATGATAAAAATAATGCATTTGTATTGTTCATAATATCATGTGCACTTCAAGA

>14262_14262_6_CCSER1-SPARCL1_CCSER1_chr4_91389505_ENST00000509176_SPARCL1_chr4_88394955_ENST00000503414_length(amino acids)=578AA_BP=
MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSIS
NGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL
LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSE
MDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV
SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIPTSGDHHIFNKTSHGYEANPAKVLASSLSPF
REGRFIERRLRSSSEGTAGSSRMILKPKDGNIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS
YHSVVSCAAVVLTPMEPMIEMKKREEPEFPEPSKQGHR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FAM190A-SPARCL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM190A-SPARCL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM190A-SPARCL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCSER1C0009171Cocaine Abuse1CTD_human
HgeneCCSER1C0236736Cocaine-Related Disorders1CTD_human
HgeneCCSER1C0600427Cocaine Dependence1CTD_human
TgeneC0014175Endometriosis1CTD_human
TgeneC0014544Epilepsy1CTD_human
TgeneC0086237Epilepsy, Cryptogenic1CTD_human
TgeneC0236018Aura1CTD_human
TgeneC0269102Endometrioma1CTD_human
TgeneC0751111Awakening Epilepsy1CTD_human