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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARL3-ACO1 (FusionGDB2 ID:HG403TG48)

Fusion Gene Summary for ARL3-ACO1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARL3-ACO1
Fusion gene ID: hg403tg48
HgeneTgene
Gene symbol

ARL3

ACO1

Gene ID

403

48

Gene nameADP ribosylation factor like GTPase 3aconitase 1
SynonymsARFL3|JBTS35|RP83ACONS|HEL60|IREB1|IREBP|IREBP1|IRP1
Cytomap('ARL3')('ACO1')

10q24.32

9p21.1

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor-like protein 3ADP-ribosylation factor-like 3ARF-like 3cytoplasmic aconitate hydrataseaconitase 1, solubleaconitate hydratase, cytoplasmiccitrate hydro-lyasecytoplasmic aconitasecytosplasmic aconitaseepididymis luminal protein 60epididymis secretory sperm binding proteinferritin repressor proteiniron
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000260746, ENST00000260746, 
Fusion gene scores* DoF score3 X 3 X 2=189 X 12 X 5=540
# samples 312
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARL3 [Title/Abstract] AND ACO1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARL3(104445573)-ACO1(32440463), # samples:1
Anticipated loss of major functional domain due to fusion event.ACO1-ARL3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACO1-ARL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARL3-ACO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARL3-ACO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARL3-ACO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARL3-ACO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARL3

GO:0007264

small GTPase mediated signal transduction

22085962

TgeneACO1

GO:0006101

citrate metabolic process

8041788|16527810

TgeneACO1

GO:0010040

response to iron(II) ion

8041788


check buttonFusion gene breakpoints across ARL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ACO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-D1-A175-01AARL3chr10

104445573

-ACO1chr9

32440463

+


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Fusion Gene ORF analysis for ARL3-ACO1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000260746ENST00000309951ARL3chr10

104445573

-ACO1chr9

32440463

+
In-frameENST00000260746ENST00000379923ARL3chr10

104445573

-ACO1chr9

32440463

+
In-frameENST00000260746ENST00000541043ARL3chr10

104445573

-ACO1chr9

32440463

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000260746ARL3chr10104445573-ENST00000541043ACO1chr932440463+17776331321055307
ENST00000260746ARL3chr10104445573-ENST00000379923ACO1chr932440463+17816331321055307
ENST00000260746ARL3chr10104445573-ENST00000309951ACO1chr932440463+57146331321055307

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000260746ENST00000541043ARL3chr10104445573-ACO1chr932440463+0.0030724370.99692756
ENST00000260746ENST00000379923ARL3chr10104445573-ACO1chr932440463+0.0030585120.9969415
ENST00000260746ENST00000309951ARL3chr10104445573-ACO1chr932440463+0.0005903960.99940956

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Fusion Genomic Features for ARL3-ACO1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARL3chr10104445572-ACO1chr932440462+6.88E-080.9999999
ARL3chr10104445572-ACO1chr932440462+6.88E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARL3-ACO1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:104445573/chr9:32440463)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARL3chr10:104445573chr9:32440463ENST00000260746-56126_129167183.0Nucleotide bindingGTP
HgeneARL3chr10:104445573chr9:32440463ENST00000260746-56159_161167183.0Nucleotide bindingGTP
HgeneARL3chr10:104445573chr9:32440463ENST00000260746-5624_31167183.0Nucleotide bindingGTP
HgeneARL3chr10:104445573chr9:32440463ENST00000260746-5667_71167183.0Nucleotide bindingGTP
TgeneACO1chr10:104445573chr9:32440463ENST000003099511721779_780749890.0RegionSubstrate binding
TgeneACO1chr10:104445573chr9:32440463ENST000003799231822779_780749890.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneACO1chr10:104445573chr9:32440463ENST000003099511721205_207749890.0RegionSubstrate binding
TgeneACO1chr10:104445573chr9:32440463ENST000003799231822205_207749890.0RegionSubstrate binding


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Fusion Gene Sequence for ARL3-ACO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6597_6597_1_ARL3-ACO1_ARL3_chr10_104445573_ENST00000260746_ACO1_chr9_32440463_ENST00000309951_length(transcript)=5714nt_BP=633nt
ACCCCGCCCCGTATTGCTGCTCAGCTCCTCAGCTGTGCGTGCGAGGGACGTCGGGGGCGGCGCCGCAGCAGTTGCCCCTGGTAACGGGGG
AGGCAGCAGGAGGAGGAGGAGGAGGAGGGACTCGGCGGGAGGATGGGCTTGCTCTCAATTTTGCGCAAGTTGAAAAGTGCACCAGACCAG
GAGGTGAGAATACTTCTCCTGGGCTTGGATAATGCTGGCAAGACCACTCTTCTGAAGCAGCTTGCATCTGAAGACATCAGCCACATCACA
CCTACACAGGGTTTCAACATCAAAAGTGTACAATCACAAGGTTTTAAACTGAATGTATGGGACATTGGTGGACAGAGGAAAATCAGACCA
TACTGGAAGAATTATTTTGAAAATACCGATATTCTTATATATGTAATCGACAGTGCAGACAGAAAAAGATTTGAAGAGACGGGTCAGGAA
CTAGCGGAATTACTGGAGGAAGAAAAACTAAGTTGTGTGCCAGTGCTCATCTTTGCTAATAAGCAGGATTTGCTCACAGCAGCCCCTGCC
TCTGAAATTGCAGAAGGACTGAACCTGCATACCATCCGCGACCGAGTCTGGCAGATCCAGTCTTGCTCAGCTCTCACAGGAGAGGGCGTT
CAGCTTGATGTGTTTGATGCTGCTGAGCGGTACCAGCAGGCAGGCCTTCCCCTGATCGTTCTGGCTGGCAAAGAGTACGGTGCAGGCAGC
TCCCGAGACTGGGCAGCTAAGGGCCCTTTCCTGCTGGGAATCAAAGCCGTCCTGGCCGAGAGCTACGAGCGCATTCACCGCAGTAACCTG
GTTGGGATGGGTGTGATCCCACTTGAATATCTCCCTGGTGAGAATGCAGATGCCCTGGGGCTCACAGGGCAAGAACGATACACTATCATT
ATTCCAGAAAACCTCAAACCACAAATGAAAGTCCAGGTCAAGCTGGATACTGGCAAGACCTTCCAGGCTGTCATGAGGTTTGACACTGAT
GTGGAGCTCACTTATTTCCTCAACGGGGGCATCCTCAACTACATGATCCGCAAGATGGCCAAGTAGGAGACGTGCACTTGGTGCTGCGCC
CAGGGAGGAAGCCGCACCACCAGCCAGCGCAGGCCCTGGTGGAGAGGCCTCCCTGGCTGCCTCTGGGAGGGGTGCTGCCTTGTAGATGGA
GCAAGTGAGCACTGAGGGTCTGGTGCCAATCCTGTAGGCACAAAACCAGAAGTTTCTACATTCTCTATTTTTGTTAATCATCTTCTCTTT
TTCCAGAATTTGGAAGCTAGAATGGTGGGAATGTCAGTAGTGCCAGAAAGAGAGAACCAAGCTTGTCTTTAAAGTTACTGATCACAGGAC
GTTGCTTTTTCACTGTTTCCTATTAATCTTCAGCTGAACACAAGCAAACCTTCTCAGGAGGTGTCTCCTACCCTCTTATTGTTCCTCTTA
CGCTCTGCTCAATGAAACCTTCCTCTTGAGGGTCATTTTCCTTTCTGTATTAATTATACCAGTGTTAAGTGACATAGATAAGAACTTTGC
ACACTTCAAATCAGAGCAGTGATTCTCTCTTCTCTCCCCTTTTCCTTCAGAGTGAATCATCCAGACTCCTCATGGATAGGTCGGGTGTTA
AAGTTGTTTTGATTATGTACCTTTTGATAGATCCACATAAAAAGAAATGTGAAGTTTTCTTTTACTATCTTTTCATTTATCAAGCAGAGA
CCTTTGTTGGGAGGCGGTTTGGGAGAACACATTTCTAATTTGAATGAAATGAAATCTATTTTCAGTGAAAACTTGTTGACTTTGAGTTTT
GCTGTGTTTGTGGCTAGAGTTTTGGGATATTTAGTACAGAGTGAATCTCACACCATATCATTGGGAAGCCTGAATAACCTTCATATTCTC
CCATTTTTACAACTCTATCAGAACTGTACGGGTATAACGGAAATGTTTAGGAACCATTATGCTCGCTCTTCCCTGTTTGGGAGCAGACAA
GAAGGAAGAGTAGCCTGGTGGCAGTGGCAACGATATAAGTACATAAGGAAAAGCAGATAAACTTCAGGACACTAAAAACCAATTATCTGC
TCATTTTTACCCCTGTAGTCATTTCTGGGCATGCCTTAGTTTGCTTGGGTTGCTATAATGTAATGCCATAGACTGGCTGAAAGAACAGAA
ATGTATTTTCTCACAGTTATGGAGGCTGGAATTCTGAGATCAAAGTTGAAGCCACTTCATTTTCTGGTGAGGACACTCTTCCTGGTTTAC
AGATGGCCACCTTCTTGCTTGTTCTCACATGGCATTTCTTTGGTATGTGCCTGGTGGGGGAGAGAGAAAATAGGCTCTCATGTCTCTTCT
TACAGCAACACTAATTGTATTGGATCAGGGTCCCACTCTTATGGAGACCCAGGAAAGCTGGTGGTATAACAACTTGGTTCAAGTCCAAAT
GCCTAAGAACCTGGGGAGGGGCATGGGGAATGCTGGTATAAGTCCCAGAGTCTGAATGCCCAGGAACAAGCAGGAGCTGTGATGTCCAAG
GACAGGAGGGCAGGATCTTTGTAATGAATTTTTAATGTCAACCTTAGCACTCAGGGGATATGGCCTGGTCATCAGAACATCTGGAATCTA
ATCCTCTTTCTACTTCTCACCAGATGAGGGATCAAGACAGGTTATTTAGCATCCCTGCACTTGCGGTCCTGGGGATCTTATTTATATTCA
TTTAAAAAATAAATTACAAACAAACAGCCAGGCGCAGTGGCTCATGCCTATAATTCCATCACTTTGGGAGGCCGAGGTGGGTAGATCACC
TGAGGTCAGGAGTTCTAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGTGTGGTATTGTG
TGCCTGTAATCCCAGCTACACAGGAGGCTGAGGCAGGAGAATTGCTTAAACCCGGGATGCAGAGGCTGCAGTGAGCCGAGATCGTGCCAT
TGCACGCCCGCCTGGGCTACAAGAGCAAAGCTCCGTCTCAAAAAAAAAAAAAAATTACAAACAAACAGAACTCCATTGTACAAAAAAACC
TGTGATCCTCAAGTTAAGATCAGTCCTAGAATAAAAACACTAAGAATGGCTGAGAAAACAGACCTCCACCCTCTCAGCTCTCCATTACTG
AGCAGCTGGGGAGCTGTCTCGCTCCCCGCATTCAGTGGCTCCTGTGGTCTGTATTTTTGTATCCTCCCCAAAATTCAGGTGGTGAAACCT
TAACCCCCCAGGTAATGGTAATAGAAGCTGGGGCCTTTGGAAGGTGATTAGATCATGAGGGTAGTGCCTTTTAAAAGAGACTCAAGATAA
GATAGAGACCCCCTCATTTCTTCTGCCATGGGAGAACACAGCAAGAAGTCACCATCCGTGAACCAGAAAGTGGGTTCTCACCAGATACTG
AATCTGCCAGTGCCTTGAACCTAGACTTTCCAGCCAGAACTGTGAGAAATTTCTATTGTTTATAAGCCACCCAGTTGATATTTAGTTACA
GCAGCCCAACCAAGACTGTGGTTATGAGGAAACAAACACATTATTGTGGCTAGACTAATGGAATTGGGTCCCTTACCTCCAAGTACACCC
TCTGTCCTTTTCGGTAAAAATATCTTCGCCAGGCACGGTGTCTCATGCCTATGATCCCAACACTTTGGGAGGCCGAGGCTGGAGGGTTGC
TTGAGCCCAGAAGTTTGAGACCAGCCTGGGCAACACTCTACAAAAAAAAAAATAAATAAATAAATAAATAAAATAAATCAGCCAGGTGTG
CACCTGTGGTCCCAGCTGTTCAGGAGGCTGAGGTGGGAGGATCACTTGAGCCTGGGAGGTCGTGGCTATGATTGCTCCACTGCACTCCAG
CCTGGGCAATAGAGTGAGACCCTATCAATCAATCACCACCCCCCCCCCCCCCAAAAAAAAAAGTATCTTGGCCAGTGTCTCAACCTTGCC
CACTAACAAGCCTAAATAAACCAACTTCTTTTACCTGGTTCTTTAAGGGCTGCTCGTCTTACTATCCAAATTAAAAATCTGCTGTTCTCC
CTCCCATATTCTTTGCGAATGAAGATTCCCCTGTTTGTTTGGATAGTTTTCCAAATTCATTACTGCATTCCTGGCATCCGCAGCAAGCTA
AGAGTTAGTTAATATTTTTAATATAGCAAATAAGGATGAGGGATGCCCTTCATGTGTATTTACACACCAGATTTTTATGGTACATAGGGA
GTAATCTAGGGAAAAGATATATTAGGCATGAATCTTAGCTGTGGTAGAAGCACAGCTCAAATTAGCTTAAGGAAAAAAAAAAAAAAGCTG
GCTCATAGAACTTGAGGACAGTGGTGGCCATGACTATGGGCTTGATTGGATCTAGTGACTCAAGCTCCCTTCCATTTGCCCCTCCAACCA
CCCCCCCATCCCTCCACCAATCATACCTTCTGTTGGCCTCTGCAGTAGAGTGGCCTCTTCTGGGCCCTTCCACATGCCAGGGGATATGGC
CACCAGCAGTTCTGGGGAAACCATTAGTAATTTGTGATCGTAGAGATTTGTCTCCCAGTATTCCCTAGGGCAAAAATATTGGGAGTTCCT
AGTCACCTAAATGAAGAACCTTATTTTTAGCAGTTTCCCTTTCAGGGCTCTAACAGGACTGTGGAGTAATGTACGGGGTTATGTAGGAGC
AATGCAGAGCCACTTTTGAAAAACAGTAGCCAAGGTTCTACTGGCTGCCTTCTTAGGACATTATTAAATATCATAAACACAAGTGGAATT
TAACACCCAGCCAGTTTGTGTTCAACCAGACAGCGTCATTATGAACAAAGATTATATAACGATAGCTGATATTAAGTAAGTTTTAAAAGT
TGACATCCCAAGAGTGAAGCCTACTTATTCAGTACAGATTTGTTGAATGAAATTCGTAGTTTTATTTTACGGCATAATGAAACAGAGTTC
CAGACATGTACCTGCCAAATTTGGTTCTGGTTGTCTTATCGTATGCAGGCTGGATACCTGCTACTGTGCTTCTACAGGATGTTAACAGTG
TCCCCTGAGTAAAACAGTTCCACGGTCAGTACATTTGGGAACCACTGAGTTAAATGGGTTTTATCACTGCAGAACAGACACAAGAACAAT
GTGTGCTGTAAATCACTGTTTGCAGGGAAGGTGGCAGCAAATGGCACAGAAACCCACCTGACCACAGACTGCTTTCTTCTGGGCGTTCAC
GCACTGTGCTCCACAGGATACTCTTGAGAAACATTGAGCTATGGTTGGTCTGTTGTTTGAAATTCAAATAATAATGAATCCATTTTAAGG
ACAGGAATTGGTTTACTGACCTTGATGTTGGGATGACTCTTCATTTCAGGGTGAAAATATCACAGCATCAGCACAGGCCAGGACCACAGA
GATAACAAGGTGGTAGTTGTGTAACAGGTTGTGTCTGAACCACAGGAGCTTCAAAACATACACGGCTGGACACCCTGCCAGGATGCTCTA
ATGGGGCTGGGCATGTGTCCATGAAAAAGACTCCCCAGTTGTTTCTAAAATGTGGCCTTTGTTCTAGAAATGCAATGACCAGCATTTGGG
AGTCAGTCAAAAGATCCACTTCCTAAAAGCCTACCTGCTCATTTCTTTCATTCAATACATATTAACCAAGTGCCTACTTTGTTTGAGTCC

>6597_6597_1_ARL3-ACO1_ARL3_chr10_104445573_ENST00000260746_ACO1_chr9_32440463_ENST00000309951_length(amino acids)=307AA_BP=166
MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIKSVQSQGFKLNVWDIGGQRKIRPYWKNYFENTDILIY
VIDSADRKRFEETGQELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTGEGVQLDVFDAAERYQQA
GLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQVK

--------------------------------------------------------------
>6597_6597_2_ARL3-ACO1_ARL3_chr10_104445573_ENST00000260746_ACO1_chr9_32440463_ENST00000379923_length(transcript)=1781nt_BP=633nt
ACCCCGCCCCGTATTGCTGCTCAGCTCCTCAGCTGTGCGTGCGAGGGACGTCGGGGGCGGCGCCGCAGCAGTTGCCCCTGGTAACGGGGG
AGGCAGCAGGAGGAGGAGGAGGAGGAGGGACTCGGCGGGAGGATGGGCTTGCTCTCAATTTTGCGCAAGTTGAAAAGTGCACCAGACCAG
GAGGTGAGAATACTTCTCCTGGGCTTGGATAATGCTGGCAAGACCACTCTTCTGAAGCAGCTTGCATCTGAAGACATCAGCCACATCACA
CCTACACAGGGTTTCAACATCAAAAGTGTACAATCACAAGGTTTTAAACTGAATGTATGGGACATTGGTGGACAGAGGAAAATCAGACCA
TACTGGAAGAATTATTTTGAAAATACCGATATTCTTATATATGTAATCGACAGTGCAGACAGAAAAAGATTTGAAGAGACGGGTCAGGAA
CTAGCGGAATTACTGGAGGAAGAAAAACTAAGTTGTGTGCCAGTGCTCATCTTTGCTAATAAGCAGGATTTGCTCACAGCAGCCCCTGCC
TCTGAAATTGCAGAAGGACTGAACCTGCATACCATCCGCGACCGAGTCTGGCAGATCCAGTCTTGCTCAGCTCTCACAGGAGAGGGCGTT
CAGCTTGATGTGTTTGATGCTGCTGAGCGGTACCAGCAGGCAGGCCTTCCCCTGATCGTTCTGGCTGGCAAAGAGTACGGTGCAGGCAGC
TCCCGAGACTGGGCAGCTAAGGGCCCTTTCCTGCTGGGAATCAAAGCCGTCCTGGCCGAGAGCTACGAGCGCATTCACCGCAGTAACCTG
GTTGGGATGGGTGTGATCCCACTTGAATATCTCCCTGGTGAGAATGCAGATGCCCTGGGGCTCACAGGGCAAGAACGATACACTATCATT
ATTCCAGAAAACCTCAAACCACAAATGAAAGTCCAGGTCAAGCTGGATACTGGCAAGACCTTCCAGGCTGTCATGAGGTTTGACACTGAT
GTGGAGCTCACTTATTTCCTCAACGGGGGCATCCTCAACTACATGATCCGCAAGATGGCCAAGTAGGAGACGTGCACTTGGTGCTGCGCC
CAGGGAGGAAGCCGCACCACCAGCCAGCGCAGGCCCTGGTGGAGAGGCCTCCCTGGCTGCCTCTGGGAGGGGTGCTGCCTTGTAGATGGA
GCAAGTGAGCACTGAGGGTCTGGTGCCAATCCTGTAGGCACAAAACCAGAAGTTTCTACATTCTCTATTTTTGTTAATCATCTTCTCTTT
TTCCAGAATTTGGAAGCTAGAATGGTGGGAATGTCAGTAGTGCCAGAAAGAGAGAACCAAGCTTGTCTTTAAAGTTACTGATCACAGGAC
GTTGCTTTTTCACTGTTTCCTATTAATCTTCAGCTGAACACAAGCAAACCTTCTCAGGAGGTGTCTCCTACCCTCTTATTGTTCCTCTTA
CGCTCTGCTCAATGAAACCTTCCTCTTGAGGGTCATTTTCCTTTCTGTATTAATTATACCAGTGTTAAGTGACATAGATAAGAACTTTGC
ACACTTCAAATCAGAGCAGTGATTCTCTCTTCTCTCCCCTTTTCCTTCAGAGTGAATCATCCAGACTCCTCATGGATAGGTCGGGTGTTA
AAGTTGTTTTGATTATGTACCTTTTGATAGATCCACATAAAAAGAAATGTGAAGTTTTCTTTTACTATCTTTTCATTTATCAAGCAGAGA

>6597_6597_2_ARL3-ACO1_ARL3_chr10_104445573_ENST00000260746_ACO1_chr9_32440463_ENST00000379923_length(amino acids)=307AA_BP=166
MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIKSVQSQGFKLNVWDIGGQRKIRPYWKNYFENTDILIY
VIDSADRKRFEETGQELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTGEGVQLDVFDAAERYQQA
GLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQVK

--------------------------------------------------------------
>6597_6597_3_ARL3-ACO1_ARL3_chr10_104445573_ENST00000260746_ACO1_chr9_32440463_ENST00000541043_length(transcript)=1777nt_BP=633nt
ACCCCGCCCCGTATTGCTGCTCAGCTCCTCAGCTGTGCGTGCGAGGGACGTCGGGGGCGGCGCCGCAGCAGTTGCCCCTGGTAACGGGGG
AGGCAGCAGGAGGAGGAGGAGGAGGAGGGACTCGGCGGGAGGATGGGCTTGCTCTCAATTTTGCGCAAGTTGAAAAGTGCACCAGACCAG
GAGGTGAGAATACTTCTCCTGGGCTTGGATAATGCTGGCAAGACCACTCTTCTGAAGCAGCTTGCATCTGAAGACATCAGCCACATCACA
CCTACACAGGGTTTCAACATCAAAAGTGTACAATCACAAGGTTTTAAACTGAATGTATGGGACATTGGTGGACAGAGGAAAATCAGACCA
TACTGGAAGAATTATTTTGAAAATACCGATATTCTTATATATGTAATCGACAGTGCAGACAGAAAAAGATTTGAAGAGACGGGTCAGGAA
CTAGCGGAATTACTGGAGGAAGAAAAACTAAGTTGTGTGCCAGTGCTCATCTTTGCTAATAAGCAGGATTTGCTCACAGCAGCCCCTGCC
TCTGAAATTGCAGAAGGACTGAACCTGCATACCATCCGCGACCGAGTCTGGCAGATCCAGTCTTGCTCAGCTCTCACAGGAGAGGGCGTT
CAGCTTGATGTGTTTGATGCTGCTGAGCGGTACCAGCAGGCAGGCCTTCCCCTGATCGTTCTGGCTGGCAAAGAGTACGGTGCAGGCAGC
TCCCGAGACTGGGCAGCTAAGGGCCCTTTCCTGCTGGGAATCAAAGCCGTCCTGGCCGAGAGCTACGAGCGCATTCACCGCAGTAACCTG
GTTGGGATGGGTGTGATCCCACTTGAATATCTCCCTGGTGAGAATGCAGATGCCCTGGGGCTCACAGGGCAAGAACGATACACTATCATT
ATTCCAGAAAACCTCAAACCACAAATGAAAGTCCAGGTCAAGCTGGATACTGGCAAGACCTTCCAGGCTGTCATGAGGTTTGACACTGAT
GTGGAGCTCACTTATTTCCTCAACGGGGGCATCCTCAACTACATGATCCGCAAGATGGCCAAGTAGGAGACGTGCACTTGGTGCTGCGCC
CAGGGAGGAAGCCGCACCACCAGCCAGCGCAGGCCCTGGTGGAGAGGCCTCCCTGGCTGCCTCTGGGAGGGGTGCTGCCTTGTAGATGGA
GCAAGTGAGCACTGAGGGTCTGGTGCCAATCCTGTAGGCACAAAACCAGAAGTTTCTACATTCTCTATTTTTGTTAATCATCTTCTCTTT
TTCCAGAATTTGGAAGCTAGAATGGTGGGAATGTCAGTAGTGCCAGAAAGAGAGAACCAAGCTTGTCTTTAAAGTTACTGATCACAGGAC
GTTGCTTTTTCACTGTTTCCTATTAATCTTCAGCTGAACACAAGCAAACCTTCTCAGGAGGTGTCTCCTACCCTCTTATTGTTCCTCTTA
CGCTCTGCTCAATGAAACCTTCCTCTTGAGGGTCATTTTCCTTTCTGTATTAATTATACCAGTGTTAAGTGACATAGATAAGAACTTTGC
ACACTTCAAATCAGAGCAGTGATTCTCTCTTCTCTCCCCTTTTCCTTCAGAGTGAATCATCCAGACTCCTCATGGATAGGTCGGGTGTTA
AAGTTGTTTTGATTATGTACCTTTTGATAGATCCACATAAAAAGAAATGTGAAGTTTTCTTTTACTATCTTTTCATTTATCAAGCAGAGA

>6597_6597_3_ARL3-ACO1_ARL3_chr10_104445573_ENST00000260746_ACO1_chr9_32440463_ENST00000541043_length(amino acids)=307AA_BP=166
MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIKSVQSQGFKLNVWDIGGQRKIRPYWKNYFENTDILIY
VIDSADRKRFEETGQELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTGEGVQLDVFDAAERYQQA
GLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQVK

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Fusion Gene PPI Analysis for ARL3-ACO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARL3-ACO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARL3-ACO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARL3C0035334Retinitis Pigmentosa1ORPHANET
HgeneARL3C0431399Familial aplasia of the vermis1ORPHANET
HgeneARL3C3553264JOUBERT SYNDROME 171GENOMICS_ENGLAND
HgeneARL3C4551568Joubert syndrome 11ORPHANET
HgeneARL3C4748442JOUBERT SYNDROME 351UNIPROT
HgeneARL3C4748536RETINITIS PIGMENTOSA 831UNIPROT
TgeneC0027626Neoplasm Invasiveness1CTD_human
TgeneC0029408Degenerative polyarthritis1CTD_human
TgeneC0086743Osteoarthrosis Deformans1CTD_human