|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CUEDC1-BRMS1 (FusionGDB2 ID:HG404093TG25855) |
Fusion Gene Summary for CUEDC1-BRMS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CUEDC1-BRMS1 | Fusion gene ID: hg404093tg25855 | Hgene | Tgene | Gene symbol | CUEDC1 | BRMS1 | Gene ID | 404093 | 25855 |
| Gene name | CUE domain containing 1 | BRMS1 transcriptional repressor and anoikis regulator | |
| Synonyms | - | - | |
| Cytomap | ('CUEDC1')('BRMS1') 17q22 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CUE domain-containing protein 1 | breast cancer metastasis-suppressor 1breast cancer metastasis suppressor 1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9NWM3 | Q9HCU9 | |
| Ensembl transtripts involved in fusion gene | ENST00000578357, ENST00000407144, ENST00000360238, ENST00000577830, ENST00000577840, | ||
| Fusion gene scores | * DoF score | 26 X 15 X 8=3120 | 3 X 3 X 3=27 |
| # samples | 27 | 3 | |
| ** MAII score | log2(27/3120*10)=-3.53051471669878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CUEDC1 [Title/Abstract] AND BRMS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CUEDC1(55945510)-BRMS1(66106256), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | CUEDC1-BRMS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CUEDC1-BRMS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CUEDC1-BRMS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CUEDC1-BRMS1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. CUEDC1-BRMS1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. CUEDC1-BRMS1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | BRMS1 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 17000776 |
| Tgene | BRMS1 | GO:0042981 | regulation of apoptotic process | 17000776 |
| Tgene | BRMS1 | GO:0045892 | negative regulation of transcription, DNA-templated | 20830743 |
| Tgene | BRMS1 | GO:0090312 | positive regulation of protein deacetylation | 17000776 |
| Fusion gene breakpoints across CUEDC1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across BRMS1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | OV | TCGA-13-0913 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - |
Top |
Fusion Gene ORF analysis for CUEDC1-BRMS1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000578357 | ENST00000359957 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - |
| 5UTR-3CDS | ENST00000578357 | ENST00000425825 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - |
| Frame-shift | ENST00000407144 | ENST00000359957 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - |
| Frame-shift | ENST00000407144 | ENST00000425825 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - |
| In-frame | ENST00000360238 | ENST00000359957 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - |
| In-frame | ENST00000360238 | ENST00000425825 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - |
| In-frame | ENST00000577830 | ENST00000359957 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - |
| In-frame | ENST00000577830 | ENST00000425825 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - |
| In-frame | ENST00000577840 | ENST00000359957 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - |
| In-frame | ENST00000577840 | ENST00000425825 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000577830 | CUEDC1 | chr17 | 55945510 | - | ENST00000425825 | BRMS1 | chr11 | 66106256 | - | 2028 | 1448 | 1220 | 0 | 407 |
| ENST00000577830 | CUEDC1 | chr17 | 55945510 | - | ENST00000359957 | BRMS1 | chr11 | 66106256 | - | 2104 | 1448 | 1220 | 0 | 407 |
| ENST00000360238 | CUEDC1 | chr17 | 55945510 | - | ENST00000425825 | BRMS1 | chr11 | 66106256 | - | 2333 | 1753 | 1525 | 332 | 397 |
| ENST00000360238 | CUEDC1 | chr17 | 55945510 | - | ENST00000359957 | BRMS1 | chr11 | 66106256 | - | 2409 | 1753 | 1525 | 332 | 397 |
| ENST00000577840 | CUEDC1 | chr17 | 55945510 | - | ENST00000425825 | BRMS1 | chr11 | 66106256 | - | 1311 | 731 | 36 | 800 | 254 |
| ENST00000577840 | CUEDC1 | chr17 | 55945510 | - | ENST00000359957 | BRMS1 | chr11 | 66106256 | - | 1387 | 731 | 36 | 800 | 254 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000577830 | ENST00000425825 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - | 0.019210104 | 0.98078996 |
| ENST00000577830 | ENST00000359957 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - | 0.02068644 | 0.97931355 |
| ENST00000360238 | ENST00000425825 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - | 0.016944984 | 0.983055 |
| ENST00000360238 | ENST00000359957 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - | 0.018175047 | 0.98182493 |
| ENST00000577840 | ENST00000425825 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - | 0.032765932 | 0.967234 |
| ENST00000577840 | ENST00000359957 | CUEDC1 | chr17 | 55945510 | - | BRMS1 | chr11 | 66106256 | - | 0.03728555 | 0.9627145 |
Top |
Fusion Genomic Features for CUEDC1-BRMS1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
Top |
Fusion Protein Features for CUEDC1-BRMS1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:55945510/chr11:66106256) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CUEDC1 | BRMS1 |
| FUNCTION: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. {ECO:0000269|PubMed:14581478, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:20830743}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CUEDC1 | chr17:55945510 | chr11:66106256 | ENST00000360238 | - | 8 | 11 | 110_154 | 344 | 162.33333333333334 | Compositional bias | Note=Pro-rich |
| Hgene | CUEDC1 | chr17:55945510 | chr11:66106256 | ENST00000407144 | - | 8 | 11 | 110_154 | 344 | 350.0 | Compositional bias | Note=Pro-rich |
| Hgene | CUEDC1 | chr17:55945510 | chr11:66106256 | ENST00000577830 | - | 8 | 11 | 110_154 | 344 | 841.6666666666666 | Compositional bias | Note=Pro-rich |
| Hgene | CUEDC1 | chr17:55945510 | chr11:66106256 | ENST00000360238 | - | 8 | 11 | 46_89 | 344 | 162.33333333333334 | Domain | CUE |
| Hgene | CUEDC1 | chr17:55945510 | chr11:66106256 | ENST00000407144 | - | 8 | 11 | 46_89 | 344 | 350.0 | Domain | CUE |
| Hgene | CUEDC1 | chr17:55945510 | chr11:66106256 | ENST00000577830 | - | 8 | 11 | 46_89 | 344 | 841.6666666666666 | Domain | CUE |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | BRMS1 | chr17:55945510 | chr11:66106256 | ENST00000359957 | 6 | 10 | 51_98 | 209 | 247.0 | Coiled coil | Ontology_term=ECO:0000269 |
Top |
Fusion Gene Sequence for CUEDC1-BRMS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >20620_20620_1_CUEDC1-BRMS1_CUEDC1_chr17_55945510_ENST00000360238_BRMS1_chr11_66106256_ENST00000359957_length(transcript)=2409nt_BP=1753nt AAGTGTGGCCACTTCCTCTTGCCTGGCCTGACTCACCCTGGCTGCTGCCCATTGTGGCTGCCATGGAAATACAACTCGAGGAGAACCCAG ACCAGGACAGGGAGGCCATGTTCTGGGTGGCAGTGGAGCCTGGCAAGGTGCCCTCCTGGCCTGGGACTGCTGTGGCAGAGGAAGCATGAG GTGGGGCCTGGCCTGCCCAGCTCAGAGCTGAGGTGCCCCCTTGGTTTTTTACCTCCCTGTTCCCTGGCTGGCCCACTGCACCCACGCACT CAACGCAGTGGCTTCGCTCCTCCTCCAGGATGGCTGGAGGTGGGACCATTGCCAGGATGGCCTCAAGTGCCCAGCCCTCCTGGAAGACTC AGTTTCCCTCTTTGTCCCATGCAGAGGTGCAGAGATTCATTATTGTGGGACCATCCGTGAAACCGGTGCCAGGATGCACCGGGGGTGTGG ATGACCGGCCGCCCAGCCCCAGCACGGCCCGGTCCCGCATGCCACCGCCCCGCGAGGACCGCTCTCCAAGGGCTGCCTGGGGCCCCGCGC CCGTACTCTCCTAACCCGGAGCTCTTGGCAGCCCATTGCTGCCTGGCTACCCGGGGAGGAGGAGGCGCAGGAGTGAGCTGCCCGAGACCG CAGGGCAAGTAAGCGGCTGACGGCGGAAAGACCCTGGGGAAGGGGCTTTGCGGCCGGCTAGAAACATTTTCCCCAAGCGGCTCCGCAAAA TGACCAGCCTGTTCCGCCGGAGCAGCAGCGGCAGCGGCGGGGGTGGCACCGCCGGGGCACGCGGGGGCGGGGGAGGCACGGCCGCCCCCC AGGAGCTCAACAACAGCCGGCCTGCCCGCCAGGTGCGCCGCCTGGAGTTCAACCAGGCCATGGACGACTTCAAGACCATGTTCCCCAACA TGGATTACGACATCATCGAATGCGTGCTGCGCGCCAACAGCGGCGCTGTGGACGCCACCATCGACCAGCTGCTGCAGATGAACCTGGAGG GCGGTGGCAGCAGCGGCGGCGTCTATGAGGACAGCTCCGACTCGGAGGACAGCATCCCCCCGGAGATCTTGGAAAGGACTTTGGAACCTG ATAGCTCGGATGAAGAGCCCCCACCTGTGTACTCCCCGCCAGCCTACCACATGCACGTGTTCGACCGGCCCTACCCTCTGGCTCCCCCGA CTCCGCCTCCCCGTATCGACGCGCTGGGCTCTGGAGCCCCTACAAGCCAGAGACGCTATCGGAACTGGAACCCACCACTGCTGGGCAACC TTCCGGATGACTTTCTCCGCATCCTGCCCCAGCAGCTGGACAGCATACAGGGTAACGCTGGGGGCCCCAAGCCTGGGAGTGGAGAGGGAT GTCCACCTGCCATGGCTGGGCCAGGGCCCGGAGACCAGGAGAGCCGCTGGAAGCAGTACCTGGAGGACGAGAGGATCGCGCTTTTCCTGC AGAACGAGGAGTTCATGAAGGAGCTGCAACGGAACCGCGACTTCCTCCTCGCTCTGGAGAGAGATCGATTGAAATACGAATCCCAGAAAT CTAAATCCAGCAGCGTGGCTGTCGGAAACGACTTTGGCTTTTCCTCTCCTGTCCCAGGAACTGGCGACGCCAACCCCGCTGTGTCTGAAG ATGCCTTATTCAGGGACAAGCTGAAACACATGGGAAAGTCCACCCGGAGGAAACTGTTTGAACTTGCCCGAGCCTTCTCAGAGAAGACCA AAATGAGGAAGTCAAAGAGGAAACACTTGTTGAAGCATCAGTCGCCCATACATCGTGTACATGCTTCAAGAGATCGACATCCTGGAGGAC TGGACAGCCATCAAAAAGGCTAGGGCAGCTGTGTCCCCTCAGAAGAGAAAATCGGATGGACCTTGACCCTGCTGTTCACAGCCAGGGGGA CCCTCAGAGCAGCTGGCACTGCACCCAGGATTCTCGTCTTCCTCCTGCAGACAGGCGGACCCACAGGCCCCTCAGGGTCTGCCCAGCCAG GCTCCTGTGGTGCTGCTGGGCCCTCCCACTCCATCTGGCACTGGCCTGGACTCCTCCTCTGCCCTCCTCGAGGCCTGCACAGCTGTGGCC GTGGAGCTGACCTGACCAGGCAAGGCTGCTGTCTCCATCCCTGAGCCGCCTGCCACCTCCCACTCCTGAAGATCCATCTCTTGGGGCTCC CCTGACAGAGAAGACAGCCGAAGTCAAAGCCACATCCTCTTGCTGATGTTGGATGCAGGCTGTCCGGCCTCAGGGCCAGGGAGCCAGTTT CCACTGTGCGGGAACTCTGAGTCAGACGTGATTATCTGGGGGTCTGTCCACCCTGGCTGGATCTGGAGGCAAGATGCCAGGCCCCCCAGG >20620_20620_1_CUEDC1-BRMS1_CUEDC1_chr17_55945510_ENST00000360238_BRMS1_chr11_66106256_ENST00000359957_length(amino acids)=397AA_BP= MGFVFQSISLQSEEEVAVPLQLLHELLVLQEKRDPLVLQVLLPAALLVSGPWPSHGRWTSLSTPRLGAPSVTLYAVQLLGQDAEKVIRKV AQQWWVPVPIASLACRGSRAQRVDTGRRSRGSQRVGPVEHVHVVGWRGVHRWGLFIRAIRFQSPFQDLRGDAVLRVGAVLIDAAAAATAL QVHLQQLVDGGVHSAAVGAQHAFDDVVIHVGEHGLEVVHGLVELQAAHLAGRPAVVELLGGGRASPAPACPGGATPAAAAAAPAEQAGHF AEPLGENVSSRPQSPFPRVFPPSAAYLPCGLGQLTPAPPPPRVARQQWAAKSSGLGEYGRGAPGSPWRAVLAGRWHAGPGRAGAGRPVIH -------------------------------------------------------------- >20620_20620_2_CUEDC1-BRMS1_CUEDC1_chr17_55945510_ENST00000360238_BRMS1_chr11_66106256_ENST00000425825_length(transcript)=2333nt_BP=1753nt AAGTGTGGCCACTTCCTCTTGCCTGGCCTGACTCACCCTGGCTGCTGCCCATTGTGGCTGCCATGGAAATACAACTCGAGGAGAACCCAG ACCAGGACAGGGAGGCCATGTTCTGGGTGGCAGTGGAGCCTGGCAAGGTGCCCTCCTGGCCTGGGACTGCTGTGGCAGAGGAAGCATGAG GTGGGGCCTGGCCTGCCCAGCTCAGAGCTGAGGTGCCCCCTTGGTTTTTTACCTCCCTGTTCCCTGGCTGGCCCACTGCACCCACGCACT CAACGCAGTGGCTTCGCTCCTCCTCCAGGATGGCTGGAGGTGGGACCATTGCCAGGATGGCCTCAAGTGCCCAGCCCTCCTGGAAGACTC AGTTTCCCTCTTTGTCCCATGCAGAGGTGCAGAGATTCATTATTGTGGGACCATCCGTGAAACCGGTGCCAGGATGCACCGGGGGTGTGG ATGACCGGCCGCCCAGCCCCAGCACGGCCCGGTCCCGCATGCCACCGCCCCGCGAGGACCGCTCTCCAAGGGCTGCCTGGGGCCCCGCGC CCGTACTCTCCTAACCCGGAGCTCTTGGCAGCCCATTGCTGCCTGGCTACCCGGGGAGGAGGAGGCGCAGGAGTGAGCTGCCCGAGACCG CAGGGCAAGTAAGCGGCTGACGGCGGAAAGACCCTGGGGAAGGGGCTTTGCGGCCGGCTAGAAACATTTTCCCCAAGCGGCTCCGCAAAA TGACCAGCCTGTTCCGCCGGAGCAGCAGCGGCAGCGGCGGGGGTGGCACCGCCGGGGCACGCGGGGGCGGGGGAGGCACGGCCGCCCCCC AGGAGCTCAACAACAGCCGGCCTGCCCGCCAGGTGCGCCGCCTGGAGTTCAACCAGGCCATGGACGACTTCAAGACCATGTTCCCCAACA TGGATTACGACATCATCGAATGCGTGCTGCGCGCCAACAGCGGCGCTGTGGACGCCACCATCGACCAGCTGCTGCAGATGAACCTGGAGG GCGGTGGCAGCAGCGGCGGCGTCTATGAGGACAGCTCCGACTCGGAGGACAGCATCCCCCCGGAGATCTTGGAAAGGACTTTGGAACCTG ATAGCTCGGATGAAGAGCCCCCACCTGTGTACTCCCCGCCAGCCTACCACATGCACGTGTTCGACCGGCCCTACCCTCTGGCTCCCCCGA CTCCGCCTCCCCGTATCGACGCGCTGGGCTCTGGAGCCCCTACAAGCCAGAGACGCTATCGGAACTGGAACCCACCACTGCTGGGCAACC TTCCGGATGACTTTCTCCGCATCCTGCCCCAGCAGCTGGACAGCATACAGGGTAACGCTGGGGGCCCCAAGCCTGGGAGTGGAGAGGGAT GTCCACCTGCCATGGCTGGGCCAGGGCCCGGAGACCAGGAGAGCCGCTGGAAGCAGTACCTGGAGGACGAGAGGATCGCGCTTTTCCTGC AGAACGAGGAGTTCATGAAGGAGCTGCAACGGAACCGCGACTTCCTCCTCGCTCTGGAGAGAGATCGATTGAAATACGAATCCCAGAAAT CTAAATCCAGCAGCGTGGCTGTCGGAAACGACTTTGGCTTTTCCTCTCCTGTCCCAGGAACTGGCGACGCCAACCCCGCTGTGTCTGAAG ATGCCTTATTCAGGGACAAGCTGAAACACATGGGAAAGTCCACCCGGAGGAAACTGTTTGAACTTGCCCGAGCCTTCTCAGAGAAGACCA AAATGAGGAAGTCAAAGAGGAAACACTTGTTGAAGCATCAGTCGCCCATACATCGTGTACATGCTTCAAGAGATCGACATCCTGGAGGAC TGGACAGCCATCAAAAAGGCTAGGGCAGCTGTGTCCCCTCAGAAGAGAAAATCGGATGACAGGCGGACCCACAGGCCCCTCAGGGTCTGC CCAGCCAGGCTCCTGTGGTGCTGCTGGGCCCTCCCACTCCATCTGGCACTGGCCTGGACTCCTCCTCTGCCCTCCTCGAGGCCTGCACAG CTGTGGCCGTGGAGCTGACCTGACCAGGCAAGGCTGCTGTCTCCATCCCTGAGCCGCCTGCCACCTCCCACTCCTGAAGATCCATCTCTT GGGGCTCCCCTGACAGAGAAGACAGCCGAAGTCAAAGCCACATCCTCTTGCTGATGTTGGATGCAGGCTGTCCGGCCTCAGGGCCAGGGA GCCAGTTTCCACTGTGCGGGAACTCTGAGTCAGACGTGATTATCTGGGGGTCTGTCCACCCTGGCTGGATCTGGAGGCAAGATGCCAGGC >20620_20620_2_CUEDC1-BRMS1_CUEDC1_chr17_55945510_ENST00000360238_BRMS1_chr11_66106256_ENST00000425825_length(amino acids)=397AA_BP= MGFVFQSISLQSEEEVAVPLQLLHELLVLQEKRDPLVLQVLLPAALLVSGPWPSHGRWTSLSTPRLGAPSVTLYAVQLLGQDAEKVIRKV AQQWWVPVPIASLACRGSRAQRVDTGRRSRGSQRVGPVEHVHVVGWRGVHRWGLFIRAIRFQSPFQDLRGDAVLRVGAVLIDAAAAATAL QVHLQQLVDGGVHSAAVGAQHAFDDVVIHVGEHGLEVVHGLVELQAAHLAGRPAVVELLGGGRASPAPACPGGATPAAAAAAPAEQAGHF AEPLGENVSSRPQSPFPRVFPPSAAYLPCGLGQLTPAPPPPRVARQQWAAKSSGLGEYGRGAPGSPWRAVLAGRWHAGPGRAGAGRPVIH -------------------------------------------------------------- >20620_20620_3_CUEDC1-BRMS1_CUEDC1_chr17_55945510_ENST00000577830_BRMS1_chr11_66106256_ENST00000359957_length(transcript)=2104nt_BP=1448nt GGCCCCGCCGCCACCGCTGCGGATTGCAGCCCCTCCCCCGCCCGGCCCGCGGCCCGGCCCCTGCGGCCCGCGCGGAGCGGACGCGCGTGG CGCTGCCCGGTGGGACCATCCGTGAAACCGGTGCCAGGATGCACCGGGGGTGTGGATGACCGGCCGCCCAGCCCCAGCACGGCCCGGTCC CGCATGCCACCGCCCCGCGAGGACCGCTCTCCAAGGGCTGCCTGGGGCCCCGCGCCCGTACTCTCCTAACCCGGAGCTCTTGGCAGCCCA TTGCTGCCTGGCTACCCGGGGAGGAGGAGGCGCAGGAGTGAGCTGCCCGAGACCGCAGGGCAAGTAAGCGGCTGACGGCGGAAAGACCCT GGGGAAGGGGCTTTGCGGCCGGCTAGAAACATTTTCCCCAAGCGGCTCCGCAAAATGACCAGCCTGTTCCGCCGGAGCAGCAGCGGCAGC GGCGGGGGTGGCACCGCCGGGGCACGCGGGGGCGGGGGAGGCACGGCCGCCCCCCAGGAGCTCAACAACAGCCGGCCTGCCCGCCAGGTG CGCCGCCTGGAGTTCAACCAGGCCATGGACGACTTCAAGACCATGTTCCCCAACATGGATTACGACATCATCGAATGCGTGCTGCGCGCC AACAGCGGCGCTGTGGACGCCACCATCGACCAGCTGCTGCAGATGAACCTGGAGGGCGGTGGCAGCAGCGGCGGCGTCTATGAGGACAGC TCCGACTCGGAGGACAGCATCCCCCCGGAGATCTTGGAAAGGACTTTGGAACCTGATAGCTCGGATGAAGAGCCCCCACCTGTGTACTCC CCGCCAGCCTACCACATGCACGTGTTCGACCGGCCCTACCCTCTGGCTCCCCCGACTCCGCCTCCCCGTATCGACGCGCTGGGCTCTGGA GCCCCTACAAGCCAGAGACGCTATCGGAACTGGAACCCACCACTGCTGGGCAACCTTCCGGATGACTTTCTCCGCATCCTGCCCCAGCAG CTGGACAGCATACAGGGTAACGCTGGGGGCCCCAAGCCTGGGAGTGGAGAGGGATGTCCACCTGCCATGGCTGGGCCAGGGCCCGGAGAC CAGGAGAGCCGCTGGAAGCAGTACCTGGAGGACGAGAGGATCGCGCTTTTCCTGCAGAACGAGGAGTTCATGAAGGAGCTGCAACGGAAC CGCGACTTCCTCCTCGCTCTGGAGAGAGATCGATTGAAATACGAATCCCAGAAATCTAAATCCAGCAGCGTGGCTGTCGGAAACGACTTT GGCTTTTCCTCTCCTGTCCCAGGAACTGGCGACGCCAACCCCGCTGTGTCTGAAGATGCCTTATTCAGGGACAAGCTGAAACACATGGGA AAGTCCACCCGGAGGAAACTGTTTGAACTTGCCCGAGCCTTCTCAGAGAAGACCAAAATGAGGAAGTCAAAGAGGAAACACTTGTTGAAG CATCAGTCGCCCATACATCGTGTACATGCTTCAAGAGATCGACATCCTGGAGGACTGGACAGCCATCAAAAAGGCTAGGGCAGCTGTGTC CCCTCAGAAGAGAAAATCGGATGGACCTTGACCCTGCTGTTCACAGCCAGGGGGACCCTCAGAGCAGCTGGCACTGCACCCAGGATTCTC GTCTTCCTCCTGCAGACAGGCGGACCCACAGGCCCCTCAGGGTCTGCCCAGCCAGGCTCCTGTGGTGCTGCTGGGCCCTCCCACTCCATC TGGCACTGGCCTGGACTCCTCCTCTGCCCTCCTCGAGGCCTGCACAGCTGTGGCCGTGGAGCTGACCTGACCAGGCAAGGCTGCTGTCTC CATCCCTGAGCCGCCTGCCACCTCCCACTCCTGAAGATCCATCTCTTGGGGCTCCCCTGACAGAGAAGACAGCCGAAGTCAAAGCCACAT CCTCTTGCTGATGTTGGATGCAGGCTGTCCGGCCTCAGGGCCAGGGAGCCAGTTTCCACTGTGCGGGAACTCTGAGTCAGACGTGATTAT CTGGGGGTCTGTCCACCCTGGCTGGATCTGGAGGCAAGATGCCAGGCCCCCCAGGTGTTCTCAGGGCAGTTCTTGGTGTCTGCTTCTCAG >20620_20620_3_CUEDC1-BRMS1_CUEDC1_chr17_55945510_ENST00000577830_BRMS1_chr11_66106256_ENST00000359957_length(amino acids)=407AA_BP= MGFVFQSISLQSEEEVAVPLQLLHELLVLQEKRDPLVLQVLLPAALLVSGPWPSHGRWTSLSTPRLGAPSVTLYAVQLLGQDAEKVIRKV AQQWWVPVPIASLACRGSRAQRVDTGRRSRGSQRVGPVEHVHVVGWRGVHRWGLFIRAIRFQSPFQDLRGDAVLRVGAVLIDAAAAATAL QVHLQQLVDGGVHSAAVGAQHAFDDVVIHVGEHGLEVVHGLVELQAAHLAGRPAVVELLGGGRASPAPACPGGATPAAAAAAPAEQAGHF AEPLGENVSSRPQSPFPRVFPPSAAYLPCGLGQLTPAPPPPRVARQQWAAKSSGLGEYGRGAPGSPWRAVLAGRWHAGPGRAGAGRPVIH -------------------------------------------------------------- >20620_20620_4_CUEDC1-BRMS1_CUEDC1_chr17_55945510_ENST00000577830_BRMS1_chr11_66106256_ENST00000425825_length(transcript)=2028nt_BP=1448nt GGCCCCGCCGCCACCGCTGCGGATTGCAGCCCCTCCCCCGCCCGGCCCGCGGCCCGGCCCCTGCGGCCCGCGCGGAGCGGACGCGCGTGG CGCTGCCCGGTGGGACCATCCGTGAAACCGGTGCCAGGATGCACCGGGGGTGTGGATGACCGGCCGCCCAGCCCCAGCACGGCCCGGTCC CGCATGCCACCGCCCCGCGAGGACCGCTCTCCAAGGGCTGCCTGGGGCCCCGCGCCCGTACTCTCCTAACCCGGAGCTCTTGGCAGCCCA TTGCTGCCTGGCTACCCGGGGAGGAGGAGGCGCAGGAGTGAGCTGCCCGAGACCGCAGGGCAAGTAAGCGGCTGACGGCGGAAAGACCCT GGGGAAGGGGCTTTGCGGCCGGCTAGAAACATTTTCCCCAAGCGGCTCCGCAAAATGACCAGCCTGTTCCGCCGGAGCAGCAGCGGCAGC GGCGGGGGTGGCACCGCCGGGGCACGCGGGGGCGGGGGAGGCACGGCCGCCCCCCAGGAGCTCAACAACAGCCGGCCTGCCCGCCAGGTG CGCCGCCTGGAGTTCAACCAGGCCATGGACGACTTCAAGACCATGTTCCCCAACATGGATTACGACATCATCGAATGCGTGCTGCGCGCC AACAGCGGCGCTGTGGACGCCACCATCGACCAGCTGCTGCAGATGAACCTGGAGGGCGGTGGCAGCAGCGGCGGCGTCTATGAGGACAGC TCCGACTCGGAGGACAGCATCCCCCCGGAGATCTTGGAAAGGACTTTGGAACCTGATAGCTCGGATGAAGAGCCCCCACCTGTGTACTCC CCGCCAGCCTACCACATGCACGTGTTCGACCGGCCCTACCCTCTGGCTCCCCCGACTCCGCCTCCCCGTATCGACGCGCTGGGCTCTGGA GCCCCTACAAGCCAGAGACGCTATCGGAACTGGAACCCACCACTGCTGGGCAACCTTCCGGATGACTTTCTCCGCATCCTGCCCCAGCAG CTGGACAGCATACAGGGTAACGCTGGGGGCCCCAAGCCTGGGAGTGGAGAGGGATGTCCACCTGCCATGGCTGGGCCAGGGCCCGGAGAC CAGGAGAGCCGCTGGAAGCAGTACCTGGAGGACGAGAGGATCGCGCTTTTCCTGCAGAACGAGGAGTTCATGAAGGAGCTGCAACGGAAC CGCGACTTCCTCCTCGCTCTGGAGAGAGATCGATTGAAATACGAATCCCAGAAATCTAAATCCAGCAGCGTGGCTGTCGGAAACGACTTT GGCTTTTCCTCTCCTGTCCCAGGAACTGGCGACGCCAACCCCGCTGTGTCTGAAGATGCCTTATTCAGGGACAAGCTGAAACACATGGGA AAGTCCACCCGGAGGAAACTGTTTGAACTTGCCCGAGCCTTCTCAGAGAAGACCAAAATGAGGAAGTCAAAGAGGAAACACTTGTTGAAG CATCAGTCGCCCATACATCGTGTACATGCTTCAAGAGATCGACATCCTGGAGGACTGGACAGCCATCAAAAAGGCTAGGGCAGCTGTGTC CCCTCAGAAGAGAAAATCGGATGACAGGCGGACCCACAGGCCCCTCAGGGTCTGCCCAGCCAGGCTCCTGTGGTGCTGCTGGGCCCTCCC ACTCCATCTGGCACTGGCCTGGACTCCTCCTCTGCCCTCCTCGAGGCCTGCACAGCTGTGGCCGTGGAGCTGACCTGACCAGGCAAGGCT GCTGTCTCCATCCCTGAGCCGCCTGCCACCTCCCACTCCTGAAGATCCATCTCTTGGGGCTCCCCTGACAGAGAAGACAGCCGAAGTCAA AGCCACATCCTCTTGCTGATGTTGGATGCAGGCTGTCCGGCCTCAGGGCCAGGGAGCCAGTTTCCACTGTGCGGGAACTCTGAGTCAGAC GTGATTATCTGGGGGTCTGTCCACCCTGGCTGGATCTGGAGGCAAGATGCCAGGCCCCCCAGGTGTTCTCAGGGCAGTTCTTGGTGTCTG >20620_20620_4_CUEDC1-BRMS1_CUEDC1_chr17_55945510_ENST00000577830_BRMS1_chr11_66106256_ENST00000425825_length(amino acids)=407AA_BP= MGFVFQSISLQSEEEVAVPLQLLHELLVLQEKRDPLVLQVLLPAALLVSGPWPSHGRWTSLSTPRLGAPSVTLYAVQLLGQDAEKVIRKV AQQWWVPVPIASLACRGSRAQRVDTGRRSRGSQRVGPVEHVHVVGWRGVHRWGLFIRAIRFQSPFQDLRGDAVLRVGAVLIDAAAAATAL QVHLQQLVDGGVHSAAVGAQHAFDDVVIHVGEHGLEVVHGLVELQAAHLAGRPAVVELLGGGRASPAPACPGGATPAAAAAAPAEQAGHF AEPLGENVSSRPQSPFPRVFPPSAAYLPCGLGQLTPAPPPPRVARQQWAAKSSGLGEYGRGAPGSPWRAVLAGRWHAGPGRAGAGRPVIH -------------------------------------------------------------- >20620_20620_5_CUEDC1-BRMS1_CUEDC1_chr17_55945510_ENST00000577840_BRMS1_chr11_66106256_ENST00000359957_length(transcript)=1387nt_BP=731nt CCCGCGCGGAGCGGACGCGCGTGGCGCTGCCCGATCTTGGAAAGGACTTTGGAACCTGATAGCTCGGATGAAGAGCCCCCACCTGTGTAC TCCCCGCCAGCCTACCACATGCACGTGTTCGACCGGCCCTACCCTCTGGCTCCCCCGACTCCGCCTCCCCGTATCGACGCGCTGGGCTCT GGAGCCCCTACAAGCCAGAGACGCTATCGGAACTGGAACCCACCACTGCTGGGCAACCTTCCGGATGACTTTCTCCGCATCCTGCCCCAG CAGCTGGACAGCATACAGGGTAACGCTGGGGGCCCCAAGCCTGGGAGTGGAGAGGGATGTCCACCTGCCATGGCTGGGCCAGGGCCCGGA GACCAGGAGAGCCGCTGGAAGCAGTACCTGGAGGACGAGAGGATCGCGCTTTTCCTGCAGAACGAGGAGTTCATGAAGGAGCTGCAACGG AACCGCGACTTCCTCCTCGCTCTGGAGAGAGATCGATTGAAATACGAATCCCAGAAATCTAAATCCAGCAGCGTGGCTGTCGGAAACGAC TTTGGCTTTTCCTCTCCTGTCCCAGGAACTGGCGACGCCAACCCCGCTGTGTCTGAAGATGCCTTATTCAGGGACAAGCTGAAACACATG GGAAAGTCCACCCGGAGGAAACTGTTTGAACTTGCCCGAGCCTTCTCAGAGAAGACCAAAATGAGGAAGTCAAAGAGGAAACACTTGTTG AAGCATCAGTCGCCCATACATCGTGTACATGCTTCAAGAGATCGACATCCTGGAGGACTGGACAGCCATCAAAAAGGCTAGGGCAGCTGT GTCCCCTCAGAAGAGAAAATCGGATGGACCTTGACCCTGCTGTTCACAGCCAGGGGGACCCTCAGAGCAGCTGGCACTGCACCCAGGATT CTCGTCTTCCTCCTGCAGACAGGCGGACCCACAGGCCCCTCAGGGTCTGCCCAGCCAGGCTCCTGTGGTGCTGCTGGGCCCTCCCACTCC ATCTGGCACTGGCCTGGACTCCTCCTCTGCCCTCCTCGAGGCCTGCACAGCTGTGGCCGTGGAGCTGACCTGACCAGGCAAGGCTGCTGT CTCCATCCCTGAGCCGCCTGCCACCTCCCACTCCTGAAGATCCATCTCTTGGGGCTCCCCTGACAGAGAAGACAGCCGAAGTCAAAGCCA CATCCTCTTGCTGATGTTGGATGCAGGCTGTCCGGCCTCAGGGCCAGGGAGCCAGTTTCCACTGTGCGGGAACTCTGAGTCAGACGTGAT TATCTGGGGGTCTGTCCACCCTGGCTGGATCTGGAGGCAAGATGCCAGGCCCCCCAGGTGTTCTCAGGGCAGTTCTTGGTGTCTGCTTCT >20620_20620_5_CUEDC1-BRMS1_CUEDC1_chr17_55945510_ENST00000577840_BRMS1_chr11_66106256_ENST00000359957_length(amino acids)=254AA_BP=232 MERTLEPDSSDEEPPPVYSPPAYHMHVFDRPYPLAPPTPPPRIDALGSGAPTSQRRYRNWNPPLLGNLPDDFLRILPQQLDSIQGNAGGP KPGSGEGCPPAMAGPGPGDQESRWKQYLEDERIALFLQNEEFMKELQRNRDFLLALERDRLKYESQKSKSSSVAVGNDFGFSSPVPGTGD -------------------------------------------------------------- >20620_20620_6_CUEDC1-BRMS1_CUEDC1_chr17_55945510_ENST00000577840_BRMS1_chr11_66106256_ENST00000425825_length(transcript)=1311nt_BP=731nt CCCGCGCGGAGCGGACGCGCGTGGCGCTGCCCGATCTTGGAAAGGACTTTGGAACCTGATAGCTCGGATGAAGAGCCCCCACCTGTGTAC TCCCCGCCAGCCTACCACATGCACGTGTTCGACCGGCCCTACCCTCTGGCTCCCCCGACTCCGCCTCCCCGTATCGACGCGCTGGGCTCT GGAGCCCCTACAAGCCAGAGACGCTATCGGAACTGGAACCCACCACTGCTGGGCAACCTTCCGGATGACTTTCTCCGCATCCTGCCCCAG CAGCTGGACAGCATACAGGGTAACGCTGGGGGCCCCAAGCCTGGGAGTGGAGAGGGATGTCCACCTGCCATGGCTGGGCCAGGGCCCGGA GACCAGGAGAGCCGCTGGAAGCAGTACCTGGAGGACGAGAGGATCGCGCTTTTCCTGCAGAACGAGGAGTTCATGAAGGAGCTGCAACGG AACCGCGACTTCCTCCTCGCTCTGGAGAGAGATCGATTGAAATACGAATCCCAGAAATCTAAATCCAGCAGCGTGGCTGTCGGAAACGAC TTTGGCTTTTCCTCTCCTGTCCCAGGAACTGGCGACGCCAACCCCGCTGTGTCTGAAGATGCCTTATTCAGGGACAAGCTGAAACACATG GGAAAGTCCACCCGGAGGAAACTGTTTGAACTTGCCCGAGCCTTCTCAGAGAAGACCAAAATGAGGAAGTCAAAGAGGAAACACTTGTTG AAGCATCAGTCGCCCATACATCGTGTACATGCTTCAAGAGATCGACATCCTGGAGGACTGGACAGCCATCAAAAAGGCTAGGGCAGCTGT GTCCCCTCAGAAGAGAAAATCGGATGACAGGCGGACCCACAGGCCCCTCAGGGTCTGCCCAGCCAGGCTCCTGTGGTGCTGCTGGGCCCT CCCACTCCATCTGGCACTGGCCTGGACTCCTCCTCTGCCCTCCTCGAGGCCTGCACAGCTGTGGCCGTGGAGCTGACCTGACCAGGCAAG GCTGCTGTCTCCATCCCTGAGCCGCCTGCCACCTCCCACTCCTGAAGATCCATCTCTTGGGGCTCCCCTGACAGAGAAGACAGCCGAAGT CAAAGCCACATCCTCTTGCTGATGTTGGATGCAGGCTGTCCGGCCTCAGGGCCAGGGAGCCAGTTTCCACTGTGCGGGAACTCTGAGTCA GACGTGATTATCTGGGGGTCTGTCCACCCTGGCTGGATCTGGAGGCAAGATGCCAGGCCCCCCAGGTGTTCTCAGGGCAGTTCTTGGTGT >20620_20620_6_CUEDC1-BRMS1_CUEDC1_chr17_55945510_ENST00000577840_BRMS1_chr11_66106256_ENST00000425825_length(amino acids)=254AA_BP=232 MERTLEPDSSDEEPPPVYSPPAYHMHVFDRPYPLAPPTPPPRIDALGSGAPTSQRRYRNWNPPLLGNLPDDFLRILPQQLDSIQGNAGGP KPGSGEGCPPAMAGPGPGDQESRWKQYLEDERIALFLQNEEFMKELQRNRDFLLALERDRLKYESQKSKSSSVAVGNDFGFSSPVPGTGD -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for CUEDC1-BRMS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for CUEDC1-BRMS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for CUEDC1-BRMS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C0027626 | Neoplasm Invasiveness | 1 | CTD_human | |
| Tgene | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies