Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ARNT-MRPL52 (FusionGDB2 ID:HG405TG122704)

Fusion Gene Summary for ARNT-MRPL52

check button Fusion gene summary
Fusion gene informationFusion gene name: ARNT-MRPL52
Fusion gene ID: hg405tg122704
HgeneTgene
Gene symbol

ARNT

MRPL52

Gene ID

405

122704

Gene namearyl hydrocarbon receptor nuclear translocatormitochondrial ribosomal protein L52
SynonymsHIF-1-beta|HIF-1beta|HIF1-beta|HIF1B|HIF1BETA|TANGO|bHLHe2-
Cytomap('ARNT')('MRPL52')

1q21.3

14q11.2

Type of geneprotein-codingprotein-coding
Descriptionaryl hydrocarbon receptor nuclear translocatorclass E basic helix-loop-helix protein 2dioxin receptor, nuclear translocatorhypoxia-inducible factor 1, beta subunit39S ribosomal protein L52, mitochondrialL52mtMRP-L52mitochondrial large ribosomal subunit protein mL52
Modification date2020031520200313
UniProtAcc.

Q86TS9

Ensembl transtripts involved in fusion geneENST00000354396, ENST00000358595, 
ENST00000505755, ENST00000515192, 
ENST00000468970, 
Fusion gene scores* DoF score18 X 16 X 9=25926 X 4 X 5=120
# samples 186
** MAII scorelog2(18/2592*10)=-3.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARNT [Title/Abstract] AND MRPL52 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARNT(150818739)-MRPL52(23303381), # samples:2
Anticipated loss of major functional domain due to fusion event.ARNT-MRPL52 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARNT-MRPL52 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARNT-MRPL52 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ARNT-MRPL52 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ARNT-MRPL52 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARNT

GO:0001666

response to hypoxia

8756616

HgeneARNT

GO:0010575

positive regulation of vascular endothelial growth factor production

8756616

HgeneARNT

GO:0043619

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

8089148

HgeneARNT

GO:0045893

positive regulation of transcription, DNA-templated

8089148

HgeneARNT

GO:0046886

positive regulation of hormone biosynthetic process

1448077


check buttonFusion gene breakpoints across ARNT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MRPL52 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KICHTCGA-KO-8404-01AARNTchr1

150818739

-MRPL52chr14

23303381

+


Top

Fusion Gene ORF analysis for ARNT-MRPL52

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000354396ENST00000461594ARNTchr1

150818739

-MRPL52chr14

23303381

+
5CDS-intronENST00000354396ENST00000555536ARNTchr1

150818739

-MRPL52chr14

23303381

+
5CDS-intronENST00000358595ENST00000461594ARNTchr1

150818739

-MRPL52chr14

23303381

+
5CDS-intronENST00000358595ENST00000555536ARNTchr1

150818739

-MRPL52chr14

23303381

+
5CDS-intronENST00000505755ENST00000461594ARNTchr1

150818739

-MRPL52chr14

23303381

+
5CDS-intronENST00000505755ENST00000555536ARNTchr1

150818739

-MRPL52chr14

23303381

+
5CDS-intronENST00000515192ENST00000461594ARNTchr1

150818739

-MRPL52chr14

23303381

+
5CDS-intronENST00000515192ENST00000555536ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000354396ENST00000355151ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000354396ENST00000397496ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000354396ENST00000397505ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000354396ENST00000432849ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000354396ENST00000553711ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000354396ENST00000555345ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000354396ENST00000556840ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000354396ENST00000557221ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000358595ENST00000355151ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000358595ENST00000397496ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000358595ENST00000397505ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000358595ENST00000432849ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000358595ENST00000553711ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000358595ENST00000555345ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000358595ENST00000556840ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000358595ENST00000557221ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000505755ENST00000355151ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000505755ENST00000397496ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000505755ENST00000397505ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000505755ENST00000432849ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000505755ENST00000553711ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000505755ENST00000555345ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000505755ENST00000556840ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000505755ENST00000557221ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000515192ENST00000311892ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000515192ENST00000355151ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000515192ENST00000397496ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000515192ENST00000432849ARNTchr1

150818739

-MRPL52chr14

23303381

+
Frame-shiftENST00000515192ENST00000556840ARNTchr1

150818739

-MRPL52chr14

23303381

+
In-frameENST00000354396ENST00000311892ARNTchr1

150818739

-MRPL52chr14

23303381

+
In-frameENST00000358595ENST00000311892ARNTchr1

150818739

-MRPL52chr14

23303381

+
In-frameENST00000505755ENST00000311892ARNTchr1

150818739

-MRPL52chr14

23303381

+
In-frameENST00000515192ENST00000397505ARNTchr1

150818739

-MRPL52chr14

23303381

+
In-frameENST00000515192ENST00000553711ARNTchr1

150818739

-MRPL52chr14

23303381

+
In-frameENST00000515192ENST00000555345ARNTchr1

150818739

-MRPL52chr14

23303381

+
In-frameENST00000515192ENST00000557221ARNTchr1

150818739

-MRPL52chr14

23303381

+
intron-3CDSENST00000468970ENST00000311892ARNTchr1

150818739

-MRPL52chr14

23303381

+
intron-3CDSENST00000468970ENST00000355151ARNTchr1

150818739

-MRPL52chr14

23303381

+
intron-3CDSENST00000468970ENST00000397496ARNTchr1

150818739

-MRPL52chr14

23303381

+
intron-3CDSENST00000468970ENST00000397505ARNTchr1

150818739

-MRPL52chr14

23303381

+
intron-3CDSENST00000468970ENST00000432849ARNTchr1

150818739

-MRPL52chr14

23303381

+
intron-3CDSENST00000468970ENST00000553711ARNTchr1

150818739

-MRPL52chr14

23303381

+
intron-3CDSENST00000468970ENST00000555345ARNTchr1

150818739

-MRPL52chr14

23303381

+
intron-3CDSENST00000468970ENST00000556840ARNTchr1

150818739

-MRPL52chr14

23303381

+
intron-3CDSENST00000468970ENST00000557221ARNTchr1

150818739

-MRPL52chr14

23303381

+
intron-intronENST00000468970ENST00000461594ARNTchr1

150818739

-MRPL52chr14

23303381

+
intron-intronENST00000468970ENST00000555536ARNTchr1

150818739

-MRPL52chr14

23303381

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358595ARNTchr1150818739-ENST00000311892MRPL52chr1423303381+1234428102554150
ENST00000354396ARNTchr1150818739-ENST00000311892MRPL52chr1423303381+104523912365117
ENST00000515192ARNTchr1150818739-ENST00000555345MRPL52chr1423303381+970424167550127
ENST00000515192ARNTchr1150818739-ENST00000553711MRPL52chr1423303381+598424167550127
ENST00000515192ARNTchr1150818739-ENST00000397505MRPL52chr1423303381+600424167550127
ENST00000515192ARNTchr1150818739-ENST00000557221MRPL52chr1423303381+1081424167550127
ENST00000505755ARNTchr1150818739-ENST00000311892MRPL52chr1423303381+107526942395117

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358595ENST00000311892ARNTchr1150818739-MRPL52chr1423303381+0.0337526870.96624726
ENST00000354396ENST00000311892ARNTchr1150818739-MRPL52chr1423303381+0.0561132240.9438868
ENST00000515192ENST00000555345ARNTchr1150818739-MRPL52chr1423303381+0.0499435180.95005643
ENST00000515192ENST00000553711ARNTchr1150818739-MRPL52chr1423303381+0.0163209720.983679
ENST00000515192ENST00000397505ARNTchr1150818739-MRPL52chr1423303381+0.0165149960.98348504
ENST00000515192ENST00000557221ARNTchr1150818739-MRPL52chr1423303381+0.04632660.9536734
ENST00000505755ENST00000311892ARNTchr1150818739-MRPL52chr1423303381+0.0509428230.94905716

Top

Fusion Genomic Features for ARNT-MRPL52


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARNTchr1150818738-MRPL52chr1423303380+1.28E-111
ARNTchr1150818738-MRPL52chr1423303380+1.28E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ARNT-MRPL52


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:150818739/chr14:23303381)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MRPL52

Q86TS9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARNTchr1:150818739chr14:23303381ENST00000358595-422503_50775790.0Compositional biasNote=Poly-Gln
HgeneARNTchr1:150818739chr14:23303381ENST00000358595-422710_76975790.0Compositional biasNote=Gln-rich
HgeneARNTchr1:150818739chr14:23303381ENST00000358595-422738_74175790.0Compositional biasNote=Poly-Ser
HgeneARNTchr1:150818739chr14:23303381ENST00000358595-42299_10275790.0Compositional biasNote=Poly-Arg
HgeneARNTchr1:150818739chr14:23303381ENST00000505755-421503_50775775.0Compositional biasNote=Poly-Gln
HgeneARNTchr1:150818739chr14:23303381ENST00000505755-421710_76975775.0Compositional biasNote=Gln-rich
HgeneARNTchr1:150818739chr14:23303381ENST00000505755-421738_74175775.0Compositional biasNote=Poly-Ser
HgeneARNTchr1:150818739chr14:23303381ENST00000505755-42199_10275775.0Compositional biasNote=Poly-Arg
HgeneARNTchr1:150818739chr14:23303381ENST00000515192-523503_50766776.0Compositional biasNote=Poly-Gln
HgeneARNTchr1:150818739chr14:23303381ENST00000515192-523710_76966776.0Compositional biasNote=Gln-rich
HgeneARNTchr1:150818739chr14:23303381ENST00000515192-523738_74166776.0Compositional biasNote=Poly-Ser
HgeneARNTchr1:150818739chr14:23303381ENST00000515192-52399_10266776.0Compositional biasNote=Poly-Arg
HgeneARNTchr1:150818739chr14:23303381ENST00000358595-422161_23575790.0DomainPAS 1
HgeneARNTchr1:150818739chr14:23303381ENST00000358595-422349_41975790.0DomainPAS 2
HgeneARNTchr1:150818739chr14:23303381ENST00000358595-422424_46775790.0DomainNote=PAC
HgeneARNTchr1:150818739chr14:23303381ENST00000358595-42289_14275790.0DomainbHLH
HgeneARNTchr1:150818739chr14:23303381ENST00000505755-421161_23575775.0DomainPAS 1
HgeneARNTchr1:150818739chr14:23303381ENST00000505755-421349_41975775.0DomainPAS 2
HgeneARNTchr1:150818739chr14:23303381ENST00000505755-421424_46775775.0DomainNote=PAC
HgeneARNTchr1:150818739chr14:23303381ENST00000505755-42189_14275775.0DomainbHLH
HgeneARNTchr1:150818739chr14:23303381ENST00000515192-523161_23566776.0DomainPAS 1
HgeneARNTchr1:150818739chr14:23303381ENST00000515192-523349_41966776.0DomainPAS 2
HgeneARNTchr1:150818739chr14:23303381ENST00000515192-523424_46766776.0DomainNote=PAC
HgeneARNTchr1:150818739chr14:23303381ENST00000515192-52389_14266776.0DomainbHLH
HgeneARNTchr1:150818739chr14:23303381ENST00000358595-422112_16875790.0RegionRequired for heterodimer formation with HIF1A
HgeneARNTchr1:150818739chr14:23303381ENST00000358595-422112_26475790.0RegionRequired for heterodimer formation with EPAS1
HgeneARNTchr1:150818739chr14:23303381ENST00000358595-422167_17175790.0RegionMediates the transcription activity and dimerization of the AHR:ARNT complex
HgeneARNTchr1:150818739chr14:23303381ENST00000358595-42288_12875790.0RegionDNA-binding
HgeneARNTchr1:150818739chr14:23303381ENST00000505755-421112_16875775.0RegionRequired for heterodimer formation with HIF1A
HgeneARNTchr1:150818739chr14:23303381ENST00000505755-421112_26475775.0RegionRequired for heterodimer formation with EPAS1
HgeneARNTchr1:150818739chr14:23303381ENST00000505755-421167_17175775.0RegionMediates the transcription activity and dimerization of the AHR:ARNT complex
HgeneARNTchr1:150818739chr14:23303381ENST00000505755-42188_12875775.0RegionDNA-binding
HgeneARNTchr1:150818739chr14:23303381ENST00000515192-523112_16866776.0RegionRequired for heterodimer formation with HIF1A
HgeneARNTchr1:150818739chr14:23303381ENST00000515192-523112_26466776.0RegionRequired for heterodimer formation with EPAS1
HgeneARNTchr1:150818739chr14:23303381ENST00000515192-523167_17166776.0RegionMediates the transcription activity and dimerization of the AHR:ARNT complex
HgeneARNTchr1:150818739chr14:23303381ENST00000515192-52388_12866776.0RegionDNA-binding


Top

Fusion Gene Sequence for ARNT-MRPL52


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6755_6755_1_ARNT-MRPL52_ARNT_chr1_150818739_ENST00000354396_MRPL52_chr14_23303381_ENST00000311892_length(transcript)=1045nt_BP=239nt
GCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGAAATGACATCAGATGTACCATCACTGGGTCCAGCCATTGCCTCTGGAAACTCT
GGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGGCTGGATTTTGATGATGATGGAGAAGGGAAC
AGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGAGACGAGTTGTACTGCTGTCACAGGAAATGG
ACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGCAGGAAAATGCTCTTAAACCCAAAGGGGCTT
CACTGAAGAGCCCACTTCCAAGTCAATAAAAAGCAACTCCTGCCTCCCTTCCTCACCCTGTCTCTGGATTTCTTTTCTATCACCTAGATG
CTTCATCCAGCCAGAAGATAGCCTTCACGTTCCCCATCTGTCTTCAGAGAAAAAGAGCTGGGACACCAAGAACAAGCTGTTAGATCACTG
CCTGGGAGGCTTGGCTTAGTACTCTCATCTCTGGTTCCATTCCAGTTCAGCTAAGTCTTGCTTTAAAATTTTTACCTCCTAGCTGGGTGC
GGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACAAGATCAGGAGTTCGAGACCAGCCTGGCCAACCCAG
CCTGGTCAACATGGTGAAACCCTGTCCCTACTAAAGATACAAACAATTAGCCGGGCGTGGTGGGGTGCGCTTGTAATCCCAGCTACTCAG
GAGGCTGAGGCAGGAGAATCGCTTAAACTCGGGAGGTAGAGGTTGCAGTGAGCCAAGGTCACACCATTGCACTCCAACCTGGGCGACAGG
GCGAGACTCCGTCTCAAAAAAAAAAAAAAATTTACCTCCTTTGCAGGCCATAGGACTAGCCCAACTATGAGAAATAGCTGTTCTGTGAAC

>6755_6755_1_ARNT-MRPL52_ARNT_chr1_150818739_ENST00000354396_MRPL52_chr14_23303381_ENST00000311892_length(amino acids)=117AA_BP=75
MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARDELYCCHRKWTLDY

--------------------------------------------------------------
>6755_6755_2_ARNT-MRPL52_ARNT_chr1_150818739_ENST00000358595_MRPL52_chr14_23303381_ENST00000311892_length(transcript)=1234nt_BP=428nt
ATATAGGCGGGGTCTCCCCGCCGCAGGGGCTGGGATGCTGGGGGCTGCTGAAGCCGCCATCTTGGATTCCGCGGTAGCGGAGGCGGCGGT
CAGGCGCCGCTTCTGGGGAGTGGCCTTTCTTTTCCCCTCCCTCCCGGTTCGGTGGCGGCGGCTCCTCCCACTGGGGGGGGGGGTGGCGCG
GCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGAAATGACATCAGATGTACCATCACTGGGTCCAGCCATTGCCTCT
GGAAACTCTGGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGGCTGGATTTTGATGATGATGGA
GAAGGGAACAGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGAGACGAGTTGTACTGCTGTCAC
AGGAAATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGCAGGAAAATGCTCTTAAACCCA
AAGGGGCTTCACTGAAGAGCCCACTTCCAAGTCAATAAAAAGCAACTCCTGCCTCCCTTCCTCACCCTGTCTCTGGATTTCTTTTCTATC
ACCTAGATGCTTCATCCAGCCAGAAGATAGCCTTCACGTTCCCCATCTGTCTTCAGAGAAAAAGAGCTGGGACACCAAGAACAAGCTGTT
AGATCACTGCCTGGGAGGCTTGGCTTAGTACTCTCATCTCTGGTTCCATTCCAGTTCAGCTAAGTCTTGCTTTAAAATTTTTACCTCCTA
GCTGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACAAGATCAGGAGTTCGAGACCAGCCTGG
CCAACCCAGCCTGGTCAACATGGTGAAACCCTGTCCCTACTAAAGATACAAACAATTAGCCGGGCGTGGTGGGGTGCGCTTGTAATCCCA
GCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTAAACTCGGGAGGTAGAGGTTGCAGTGAGCCAAGGTCACACCATTGCACTCCAACCTG
GGCGACAGGGCGAGACTCCGTCTCAAAAAAAAAAAAAAATTTACCTCCTTTGCAGGCCATAGGACTAGCCCAACTATGAGAAATAGCTGT

>6755_6755_2_ARNT-MRPL52_ARNT_chr1_150818739_ENST00000358595_MRPL52_chr14_23303381_ENST00000311892_length(amino acids)=150AA_BP=108
MGSGLSFPLPPGSVAAAPPTGGGGGAAAVASAAMAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNS

--------------------------------------------------------------
>6755_6755_3_ARNT-MRPL52_ARNT_chr1_150818739_ENST00000505755_MRPL52_chr14_23303381_ENST00000311892_length(transcript)=1075nt_BP=269nt
ACTGGGGGGGGGGGTGGCGCGGCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGAAATGACATCAGATGTACCATCA
CTGGGTCCAGCCATTGCCTCTGGAAACTCTGGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGG
CTGGATTTTGATGATGATGGAGAAGGGAACAGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGA
GACGAGTTGTACTGCTGTCACAGGAAATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGC
AGGAAAATGCTCTTAAACCCAAAGGGGCTTCACTGAAGAGCCCACTTCCAAGTCAATAAAAAGCAACTCCTGCCTCCCTTCCTCACCCTG
TCTCTGGATTTCTTTTCTATCACCTAGATGCTTCATCCAGCCAGAAGATAGCCTTCACGTTCCCCATCTGTCTTCAGAGAAAAAGAGCTG
GGACACCAAGAACAAGCTGTTAGATCACTGCCTGGGAGGCTTGGCTTAGTACTCTCATCTCTGGTTCCATTCCAGTTCAGCTAAGTCTTG
CTTTAAAATTTTTACCTCCTAGCTGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACAAGATC
AGGAGTTCGAGACCAGCCTGGCCAACCCAGCCTGGTCAACATGGTGAAACCCTGTCCCTACTAAAGATACAAACAATTAGCCGGGCGTGG
TGGGGTGCGCTTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTAAACTCGGGAGGTAGAGGTTGCAGTGAGCCAAGGTC
ACACCATTGCACTCCAACCTGGGCGACAGGGCGAGACTCCGTCTCAAAAAAAAAAAAAAATTTACCTCCTTTGCAGGCCATAGGACTAGC

>6755_6755_3_ARNT-MRPL52_ARNT_chr1_150818739_ENST00000505755_MRPL52_chr14_23303381_ENST00000311892_length(amino acids)=117AA_BP=75
MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARDELYCCHRKWTLDY

--------------------------------------------------------------
>6755_6755_4_ARNT-MRPL52_ARNT_chr1_150818739_ENST00000515192_MRPL52_chr14_23303381_ENST00000397505_length(transcript)=600nt_BP=424nt
CTTGGATTCCGCGGTAGCGGAGGCGGCGGTCAGGCGCCGCTTCTGGGGAGTGGCCTTTCTTTTCCCCTCCCTCCCGGTTCGGTGGCGGCG
GCTCCTCCCACTGGGGGGGGGGGTGGCGCGGCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGCCTGATCTTGGACT
CAAGATTCTCCTGCCTCAGACCCCGAGTAGCTGGGACTACAGAAATGACATCAGATGTACCATCACTGGGTCCAGCCATTGCCTCTGGAA
ACTCTGGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGGCTGGATTTTGATGATGATGGAGAAG
GGAACAGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGAGACGAGTTGTACTGCTGTCACAGGA
AATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGCAGGAAAATGCTCTTAAACCCAAAGG

>6755_6755_4_ARNT-MRPL52_ARNT_chr1_150818739_ENST00000515192_MRPL52_chr14_23303381_ENST00000397505_length(amino acids)=127AA_BP=85
MILDSRFSCLRPRVAGTTEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARDELY

--------------------------------------------------------------
>6755_6755_5_ARNT-MRPL52_ARNT_chr1_150818739_ENST00000515192_MRPL52_chr14_23303381_ENST00000553711_length(transcript)=598nt_BP=424nt
CTTGGATTCCGCGGTAGCGGAGGCGGCGGTCAGGCGCCGCTTCTGGGGAGTGGCCTTTCTTTTCCCCTCCCTCCCGGTTCGGTGGCGGCG
GCTCCTCCCACTGGGGGGGGGGGTGGCGCGGCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGCCTGATCTTGGACT
CAAGATTCTCCTGCCTCAGACCCCGAGTAGCTGGGACTACAGAAATGACATCAGATGTACCATCACTGGGTCCAGCCATTGCCTCTGGAA
ACTCTGGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGGCTGGATTTTGATGATGATGGAGAAG
GGAACAGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGAGACGAGTTGTACTGCTGTCACAGGA
AATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGCAGGAAAATGCTCTTAAACCCAAAGG

>6755_6755_5_ARNT-MRPL52_ARNT_chr1_150818739_ENST00000515192_MRPL52_chr14_23303381_ENST00000553711_length(amino acids)=127AA_BP=85
MILDSRFSCLRPRVAGTTEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARDELY

--------------------------------------------------------------
>6755_6755_6_ARNT-MRPL52_ARNT_chr1_150818739_ENST00000515192_MRPL52_chr14_23303381_ENST00000555345_length(transcript)=970nt_BP=424nt
CTTGGATTCCGCGGTAGCGGAGGCGGCGGTCAGGCGCCGCTTCTGGGGAGTGGCCTTTCTTTTCCCCTCCCTCCCGGTTCGGTGGCGGCG
GCTCCTCCCACTGGGGGGGGGGGTGGCGCGGCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGCCTGATCTTGGACT
CAAGATTCTCCTGCCTCAGACCCCGAGTAGCTGGGACTACAGAAATGACATCAGATGTACCATCACTGGGTCCAGCCATTGCCTCTGGAA
ACTCTGGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGGCTGGATTTTGATGATGATGGAGAAG
GGAACAGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGAGACGAGTTGTACTGCTGTCACAGGA
AATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGCAGGAAAATGCTCTTAAACCCAAAGG
GGCTTCACTGAAGAGCCCACTTCCAAGTCAATAAAAAGCAACTCCTGCCTCCCTTCCTCACCCTGTCTCTGGATTTCTTTTCTATCACCT
AGATGCTTCATCCAGCCAGAAGATAGCCTTCACGTTCCCCATCTGTCTTCAGAGAAAAAGAGCTGGGACACCAAGAACAAGCTGTTAGAT
CACTGCCTGGGAGGCTTGGCTTAGTACTCTCATCTCTGGTTCCATTCCAGTTCAGCTAAGTCTTGCTTTAAAATTTTTACCTCCTAGCTG
GGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACAAGATCAGGAGTTCGAGACCAGCCTGGCCAA

>6755_6755_6_ARNT-MRPL52_ARNT_chr1_150818739_ENST00000515192_MRPL52_chr14_23303381_ENST00000555345_length(amino acids)=127AA_BP=85
MILDSRFSCLRPRVAGTTEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARDELY

--------------------------------------------------------------
>6755_6755_7_ARNT-MRPL52_ARNT_chr1_150818739_ENST00000515192_MRPL52_chr14_23303381_ENST00000557221_length(transcript)=1081nt_BP=424nt
CTTGGATTCCGCGGTAGCGGAGGCGGCGGTCAGGCGCCGCTTCTGGGGAGTGGCCTTTCTTTTCCCCTCCCTCCCGGTTCGGTGGCGGCG
GCTCCTCCCACTGGGGGGGGGGGTGGCGCGGCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGCCTGATCTTGGACT
CAAGATTCTCCTGCCTCAGACCCCGAGTAGCTGGGACTACAGAAATGACATCAGATGTACCATCACTGGGTCCAGCCATTGCCTCTGGAA
ACTCTGGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGGCTGGATTTTGATGATGATGGAGAAG
GGAACAGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGAGACGAGTTGTACTGCTGTCACAGGA
AATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGCAGGAAAATGCTCTTAAACCCAAAGG
GGCTTCACTGAAGAGCCCACTTCCAAGTCAATAAAAAGCAACTCCTGCCTCCCTTCCTCACCCTGTCTCTGGATTTCTTTTCTATCACCT
AGATGCTTCATCCAGCCAGAAGATAGCCTTCACGTTCCCCATCTGTCTTCAGAGAAAAAGAGCTGGGACACCAAGAACAAGCTGTTAGAT
CACTGCCTGGGAGGCTTGGCTTAGTACTCTCATCTCTGGTTCCATTCCAGTTCAGCTAAGTCTTGCTTTAAAATTTTTACCTCCTAGCTG
GGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACAAGATCAGGAGTTCGAGACCAGCCTGGCCAA
CCCAGCCTGGTCAACATGGTGAAACCCTGTCCCTACTAAAGATACAAACAATTAGCCGGGCGTGGTGGGGTGCGCTTGTAATCCCAGCTA
CTCAGGAGGCTGAGGCAGGAGAATCGCTTAAACTCGGGAGGTAGAGGTTGCAGTGAGCCAAGGTCACACCATTGCACTCCAACCTGGGCG

>6755_6755_7_ARNT-MRPL52_ARNT_chr1_150818739_ENST00000515192_MRPL52_chr14_23303381_ENST00000557221_length(amino acids)=127AA_BP=85
MILDSRFSCLRPRVAGTTEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARDELY

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ARNT-MRPL52


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ARNT-MRPL52


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ARNT-MRPL52


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARNTC0000786Spontaneous abortion1CTD_human
HgeneARNTC0000822Abortion, Tubal1CTD_human
HgeneARNTC0009402Colorectal Carcinoma1CTD_human
HgeneARNTC0009404Colorectal Neoplasms1CTD_human
HgeneARNTC0014175Endometriosis1CTD_human
HgeneARNTC0019193Hepatitis, Toxic1CTD_human
HgeneARNTC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneARNTC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneARNTC0023890Liver Cirrhosis1CTD_human
HgeneARNTC0025202melanoma1CTD_human
HgeneARNTC0027659Neoplasms, Experimental1CTD_human
HgeneARNTC0239946Fibrosis, Liver1CTD_human
HgeneARNTC0269102Endometrioma1CTD_human
HgeneARNTC0860207Drug-Induced Liver Disease1CTD_human
HgeneARNTC1262760Hepatitis, Drug-Induced1CTD_human
HgeneARNTC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneARNTC3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneARNTC3830362Early Pregnancy Loss1CTD_human
HgeneARNTC4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneARNTC4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneARNTC4552766Miscarriage1CTD_human