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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:ARNT-CBLB (FusionGDB2 ID:HG405TG868)

Fusion Gene Summary for ARNT-CBLB

Fusion gene summary

Fusion gene information	Fusion gene name: ARNT-CBLB
	Fusion gene ID: hg405tg868
		Hgene	Tgene
	Gene symbol	ARNT	CBLB
	Gene ID	405	868
	Gene name	aryl hydrocarbon receptor nuclear translocator	Cbl proto-oncogene B
	Synonyms	HIF-1-beta\|HIF-1beta\|HIF1-beta\|HIF1B\|HIF1BETA\|TANGO\|bHLHe2	Cbl-b\|Nbla00127\|RNF56
	Cytomap	('ARNT')('CBLB') 1q21.3	3q13.11
	Type of gene	protein-coding	protein-coding
	Description	aryl hydrocarbon receptor nuclear translocatorclass E basic helix-loop-helix protein 2dioxin receptor, nuclear translocatorhypoxia-inducible factor 1, beta subunit	E3 ubiquitin-protein ligase CBL-BCas-Br-M (murine) ecotropic retroviral transforming sequence bCbl proto-oncogene B, E3 ubiquitin protein ligaseCbl proto-oncogene, E3 ubiquitin protein ligase BRING finger protein 56RING-type E3 ubiquitin transferase
	Modification date	20200315	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000354396, ENST00000358595, ENST00000505755, ENST00000515192, ENST00000468970,
Fusion gene scores	* DoF score	18 X 16 X 9=2592	13 X 14 X 7=1274
	# samples	18	16
	** MAII score	log2(18/2592*10)=-3.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1274*10)=-2.99322146736894 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ARNT [Title/Abstract] AND CBLB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARNT(150849019)-CBLB(105439094), # samples:1
Anticipated loss of major functional domain due to fusion event.	ARNT-CBLB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARNT-CBLB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARNT-CBLB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARNT-CBLB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ARNT	GO:0001666	response to hypoxia	8756616
Hgene	ARNT	GO:0010575	positive regulation of vascular endothelial growth factor production	8756616
Hgene	ARNT	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	8089148
Hgene	ARNT	GO:0045893	positive regulation of transcription, DNA-templated	8089148
Hgene	ARNT	GO:0046886	positive regulation of hormone biosynthetic process	1448077

Fusion gene breakpoints across ARNT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CBLB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-O1-A52J-01A	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-

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Fusion Gene ORF analysis for ARNT-CBLB

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000354396	ENST00000545639	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5CDS-3UTR	ENST00000358595	ENST00000545639	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5CDS-3UTR	ENST00000505755	ENST00000545639	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5CDS-intron	ENST00000354396	ENST00000394027	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5CDS-intron	ENST00000354396	ENST00000403724	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5CDS-intron	ENST00000354396	ENST00000405772	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5CDS-intron	ENST00000354396	ENST00000407712	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5CDS-intron	ENST00000358595	ENST00000394027	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5CDS-intron	ENST00000358595	ENST00000403724	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5CDS-intron	ENST00000358595	ENST00000405772	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5CDS-intron	ENST00000358595	ENST00000407712	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5CDS-intron	ENST00000505755	ENST00000394027	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5CDS-intron	ENST00000505755	ENST00000403724	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5CDS-intron	ENST00000505755	ENST00000405772	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5CDS-intron	ENST00000505755	ENST00000407712	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5UTR-3CDS	ENST00000515192	ENST00000264122	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5UTR-3UTR	ENST00000515192	ENST00000545639	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5UTR-intron	ENST00000515192	ENST00000394027	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5UTR-intron	ENST00000515192	ENST00000403724	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5UTR-intron	ENST00000515192	ENST00000405772	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
5UTR-intron	ENST00000515192	ENST00000407712	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
In-frame	ENST00000354396	ENST00000264122	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
In-frame	ENST00000358595	ENST00000264122	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
In-frame	ENST00000505755	ENST00000264122	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
intron-3CDS	ENST00000468970	ENST00000264122	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
intron-3UTR	ENST00000468970	ENST00000545639	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
intron-intron	ENST00000468970	ENST00000394027	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
intron-intron	ENST00000468970	ENST00000403724	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
intron-intron	ENST00000468970	ENST00000405772	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-
intron-intron	ENST00000468970	ENST00000407712	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000358595	ARNT	chr1	150849019	-	ENST00000264122	CBLB	chr3	105439094	-	5481	226	34	1971	645
ENST00000354396	ARNT	chr1	150849019	-	ENST00000264122	CBLB	chr3	105439094	-	5292	37	4	1782	592
ENST00000505755	ARNT	chr1	150849019	-	ENST00000264122	CBLB	chr3	105439094	-	5322	67	1	1812	603

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000358595	ENST00000264122	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-	0.001083971	0.99891603
ENST00000354396	ENST00000264122	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-	0.00104341	0.99895656
ENST00000505755	ENST00000264122	ARNT	chr1	150849019	-	CBLB	chr3	105439094	-	0.001034657	0.9989654

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Fusion Genomic Features for ARNT-CBLB

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for ARNT-CBLB

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:150849019/chr3:105439094)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000264122

477_925

401

983.0

Compositional bias

Note=Pro-rich

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000403724

477_925

401

771.0

Compositional bias

Note=Pro-rich

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000264122

931_970

401

983.0

Domain

UBA

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000403724

931_970

401

771.0

Domain

UBA

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000358595

503_507

790.0

Compositional bias

Note=Poly-Gln

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000358595

710_769

790.0

Compositional bias

Note=Gln-rich

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000358595

738_741

790.0

Compositional bias

Note=Poly-Ser

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000358595

99_102

790.0

Compositional bias

Note=Poly-Arg

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000505755

503_507

775.0

Compositional bias

Note=Poly-Gln

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000505755

710_769

775.0

Compositional bias

Note=Gln-rich

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000505755

738_741

775.0

Compositional bias

Note=Poly-Ser

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000505755

99_102

775.0

Compositional bias

Note=Poly-Arg

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000515192

503_507

776.0

Compositional bias

Note=Poly-Gln

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000515192

710_769

776.0

Compositional bias

Note=Gln-rich

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000515192

738_741

776.0

Compositional bias

Note=Poly-Ser

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000515192

99_102

776.0

Compositional bias

Note=Poly-Arg

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000358595

161_235

790.0

Domain

PAS 1

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000358595

349_419

790.0

Domain

PAS 2

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000358595

424_467

790.0

Domain

Note=PAC

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000358595

89_142

790.0

Domain

bHLH

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000505755

161_235

775.0

Domain

PAS 1

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000505755

349_419

775.0

Domain

PAS 2

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000505755

424_467

775.0

Domain

Note=PAC

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000505755

89_142

775.0

Domain

bHLH

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000515192

161_235

776.0

Domain

PAS 1

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000515192

349_419

776.0

Domain

PAS 2

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000515192

424_467

776.0

Domain

Note=PAC

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000515192

89_142

776.0

Domain

bHLH

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000358595

112_168

790.0

Region

Required for heterodimer formation with HIF1A

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000358595

112_264

790.0

Region

Required for heterodimer formation with EPAS1

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000358595

167_171

790.0

Region

Mediates the transcription activity and dimerization of the AHR:ARNT complex

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000358595

88_128

790.0

Region

DNA-binding

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000505755

112_168

775.0

Region

Required for heterodimer formation with HIF1A

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000505755

112_264

775.0

Region

Required for heterodimer formation with EPAS1

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000505755

167_171

775.0

Region

Mediates the transcription activity and dimerization of the AHR:ARNT complex

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000505755

88_128

775.0

Region

DNA-binding

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000515192

112_168

776.0

Region

Required for heterodimer formation with HIF1A

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000515192

112_264

776.0

Region

Required for heterodimer formation with EPAS1

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000515192

167_171

776.0

Region

Mediates the transcription activity and dimerization of the AHR:ARNT complex

Hgene

ARNT

chr1:150849019

chr3:105439094

ENST00000515192

88_128

776.0

Region

DNA-binding

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000264122

219_232

401

983.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000403724

219_232

401

771.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000264122

35_343

401

983.0

Domain

Cbl-PTB

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000403724

35_343

401

771.0

Domain

Cbl-PTB

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000264122

168_240

401

983.0

Region

Note=EF-hand-like

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000264122

241_343

401

983.0

Region

Note=SH2-like

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000264122

344_372

401

983.0

Region

Note=Linker

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000264122

35_167

401

983.0

Region

Note=4H

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000403724

168_240

401

771.0

Region

Note=EF-hand-like

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000403724

241_343

401

771.0

Region

Note=SH2-like

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000403724

344_372

401

771.0

Region

Note=Linker

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000403724

35_167

401

771.0

Region

Note=4H

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000264122

373_412

401

983.0

Zinc finger

RING-type

Tgene

CBLB

chr1:150849019

chr3:105439094

ENST00000403724

373_412

401

771.0

Zinc finger

RING-type

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Fusion Gene Sequence for ARNT-CBLB

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>6734_6734_1_ARNT-CBLB_ARNT_chr1_150849019_ENST00000354396_CBLB_chr3_105439094_ENST00000264122_length(transcript)=5292nt_BP=37nt
GCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGGAGTCGGATGGTCAGGGCTGCCCTTTCTGTCGTTGTGAAATAAAAGGAACTGA
GCCCATAATCGTGGACCCCTTTGATCCAAGAGATGAAGGCTCCAGGTGTTGCAGCATCATTGACCCCTTTGGCATGCCGATGCTAGACTT
GGACGACGATGATGATCGTGAGGAGTCCTTGATGATGAATCGGTTGGCAAACGTCCGAAAGTGCACTGACAGGCAGAACTCACCAGTCAC
ATCACCAGGATCCTCTCCCCTTGCCCAGAGAAGAAAGCCACAGCCTGACCCACTCCAGATCCCACATCTAAGCCTGCCACCCGTGCCTCC
TCGCCTGGATCTAATTCAGAAAGGCATAGTTAGATCTCCCTGTGGCAGCCCAACGGGTTCACCAAAGTCTTCTCCTTGCATGGTGAGAAA
ACAAGATAAACCACTCCCAGCACCACCTCCTCCCTTAAGAGATCCTCCTCCACCGCCACCTGAAAGACCTCCACCAATCCCACCAGACAA
TAGACTGAGTAGACACATCCATCATGTGGAAAGCGTGCCTTCCAGAGACCCGCCAATGCCTCTTGAAGCATGGTGCCCTCGGGATGTGTT
TGGGACTAATCAGCTTGTGGGATGTCGACTCCTAGGGGAGGGCTCTCCAAAACCTGGAATCACAGCGAGTTCAAATGTCAATGGAAGGCA
CAGTAGAGTGGGCTCTGACCCAGTGCTTATGCGGAAACACAGACGCCATGATTTGCCTTTAGAAGGAGCTAAGGTCTTTTCCAATGGTCA
CCTTGGAAGTGAAGAATATGATGTTCCTCCCCGGCTTTCTCCTCCTCCTCCAGTTACCACCCTCCTCCCTAGCATAAAGTGTACTGGTCC
GTTAGCAAATTCTCTTTCAGAGAAAACAAGAGACCCAGTAGAGGAAGATGATGATGAATACAAGATTCCTTCATCCCACCCTGTTTCCCT
GAATTCACAACCATCTCATTGTCATAATGTAAAACCTCCTGTTCGGTCTTGTGATAATGGTCACTGTATGCTGAATGGAACACATGGTCC
ATCTTCAGAGAAGAAATCAAACATCCCTGACTTAAGCATATATTTAAAGGGAGATGTTTTTGATTCAGCCTCTGATCCCGTGCCATTACC
ACCTGCCAGGCCTCCAACTCGGGACAATCCAAAGCATGGTTCTTCACTCAACAGGACGCCCTCTGATTATGATCTTCTCATCCCTCCATT
AGGTGAAGATGCTTTTGATGCCCTCCCTCCATCTCTCCCACCTCCCCCACCTCCTGCAAGGCATAGTCTCATTGAACATTCAAAACCTCC
TGGCTCCAGTAGCCGGCCATCCTCAGGACAGGATCTTTTTCTTCTTCCTTCAGATCCCTTTGTTGATCTAGCAAGTGGCCAAGTTCCTTT
GCCTCCTGCTAGAAGGTTACCAGGTGAAAATGTCAAAACTAACAGAACATCACAGGACTATGATCAGCTTCCTTCATGTTCAGATGGTTC
ACAGGCACCAGCCAGACCCCCTAAACCACGACCGCGCAGGACTGCACCAGAAATTCACCACAGAAAACCCCATGGGCCTGAGGCGGCATT
GGAAAATGTCGATGCAAAAATTGCAAAACTCATGGGAGAGGGTTATGCCTTTGAAGAGGTGAAGAGAGCCTTAGAGATAGCCCAGAATAA
TGTCGAAGTTGCCCGGAGCATCCTCCGAGAATTTGCCTTCCCTCCTCCAGTATCCCCACGTCTAAATCTATAGCAGCCAGAACTGTAGAC
ACCAAAATGGAAAGCAATCGATGTATTCCAAGAGTGTGGAAATAAAGAGAACTGAGATGGAATTCAAGAGAGAAGTGTCTCCTCCTCGTG
TAGCAGCTTGAGAAGAGGCTTGGGAGTGCAGCTTCTCAAAGGAGACCGATGCTTGCTCAGGATGTCGACAGCTGTGGCTTCCTTGTTTTT
GCTAGCCATATTTTTAAATCAGGGTTGAACTGACAAAAATAATTTAAAGACGTTTACTTCCCTTGAACTTTGAACCTGTGAAATGCTTTA
CCTTGTTTACAGTTTGGCAAAGTTGCAGTTTGTTCTTGTTTTTAGTTTAGTTTTGTTTTGGTGTTTTGATACCTGTACTGTGTTCTTCAC
AGACCCTTTGTAGCGTGGTCAGGTCTGCTGTAACATTTCCCACCAACTCTCTTGCTGTCCACATCAACAGCTAAATCATTTATTCATATG
GATCTCTACCATCCCCATGCCTTGCCCAGGTCCAGTTCCATTTCTCTCATTCACAAGATGCTTTGAAGGTTCTGATTTTCAACTGATCAA
ACTAATGCAAAAAAAAAAAAGTATGTATTCTTCACTACTGAGTTTCTTCTTTGGAAACCATCACTATTGAGAGATGGGAAAAACCTGAAT
GTATAAAGCATTTATTTGTCAATAAACTGCCTTTTGTAAGGGGTTTTCACATAACATAGAGGAGCTTCCCTTTTTTGTTTAAGTTTTGTA
ACCTTTAATCCTCCATATTCTCATGTCTGTCATCCCAGGGGTGTCACAACTGTAAAAATCTACAATATTAGAAAGCAGCTACTACAGATG
TGGAAGAGAGAACACTTGTATAAGACAATGCTGTACTGAAGTTATATAACAAGGTCCCCTGATACTTATGCCTGCATTACTTTGAGGGAT
GCTGAATGAGAGGACCATCTCCCTGAAATATATTAATAATTTTCAGATAAAATTATGAACATAACATACCTTTTCTCAAGTGGAATTAGA
GTTCATTTCCCATTTAAGTGATTACACTCTATCTCCTAAGAGCTGTGGGAACCAGTTCATATTGCAGTGGAAACATTAACTCTTCGTTGC
ACTGTTGAGTGTCAAGGCTACTGTGGCAATGTTTTTTGCAAAGTTCTCAGTAATTTTCTCTCTGCAATCAAATTAGAGTTCATATTTAAT
TTGCAGATTCTCTCATTCATTGCTCCACACTGCTTTATCAAATCAGGTGAAAGAAATTAATGTAGTTTTGCCTATTTTACAAAATGGTGG
TTGGTTCTTTAAACACCATGTTATTACTCTTAATAAATCTACAAATATTTATTGAGCATCTATGATATGCTTGGTGCTGTTAGGCACTGT
GTTTTTAAAGCACAAACTCTCAAAAGCTGATTCCAGCGTAATGTTTTATTTTTGTTTTTCTGTGTTTTTTATGACAAAGTCTGTCTGATA
GACAAAGCCTGGAAGGTTTCCCCCAGGGCTTTAGAATTTAGAATTAGCTGGTTTTCATTTCAAATGGGAAATTAATGGAGAAATGAGATA
AAATCATCTCTGTGTAAATGCTTGAACCCACAGAAAGTTTTCTAAATATGGACTAATTGTGGGTTTGTGCATATTTCTGTGTCTCCTCTT
TTCACTTCACACCCACCATGATATAAAAAGATGCATCAGAGAGTGAGCCTGCCTTCAGGACCTGAAAGGACATGACTGAACATCTAGTAG
ATCTGGTGGAAATTAATGTTATACAAAAGACACGTAGACTAAGTTGACCCTGGGAGAGGAGTTAATACATTCCTTTGCAAAGTGACATGT
GCCCTTTTTTTGACAGTCTGGCTTTCATGGTATGAGATGAGGACTCACAGGCCTTGGGTAATTTCTGCTTTTGTATGAATTTTTTCAGAT
GGTTCTGAGCTGGTTATGTCCCTGGAGGGGAATTTTTCATTTGCCTTAGATGTTCTTCCCATGAGTAGGTACATGAGTGAAGTTTCTTAC
ACTTTTAAAATTGCATTGGCAAATTTTCTTTTGCTTTATGAACCCCTGTTTTGTCATTATGATTTTTCACTTGTTTTAACAGTTTCAGAT
GTCACCTTGGAATAGCACTGTTTATTTTGGCCTTTTTATGATTGCTGATGATAGGTACAGTCTAAAGGCCAAAAGTTGCCACTTCATTGT
GATAACATTGTTGCAACATTCCTAATATATTAGAGAATGATGTAAAATAAGAATGTTAGAGAACATAGCACATTCTCATTCAGTTTATAA
ACAATATTTGAAAATTTCCAGTGAGAATTAAAAAAGGACTAGTGATGATATAGCAAACCTGGACCTGAAATTTGGGGGTGGGGGGTGGGG
GGATATCTGTTTTGCAGAGAAAATTTACCAGCCTCCAGCAAAATCTCTGCATCTTGTACTCAATAGCAACCATTAGTATTGTCATTTAAA
AAGAATGAATCAAAAATTCATACGTAATGGAATGAAAAGAGGAAAACTTTCTATTAAACACTGTCAAGAAAGACCCATTGCTATCTATCA
CCTATGAAATTAAACCTAAAAAAATTTTTTTTTATTGTAAAAGCGACTGCTCGTTGATGTCTGGAAGTGATCCAGACTTTGTTTCACTGT
GATCCAAAAAGTTAGACATTCCTTCCATTTCTCAAGATTTGGTAACAATTTTTTTTTAAGTCAGCATTTCATATAATACATAAAATTAAG
ACAAATTAACTTACTGATATGTGGCCAATATCAACCCTTCTCACCCAACCCAAACATGTTCTGGAGATAGAAGGACTTATCCTCAATTAT
ATTCCAGTAAATTTATCTCCATAATCTGTTTTATCCCCTAATGTATGATATATCTCACCAAATTTTTCTAGAATTGAATAAAAGCAGTTT
TTGCTTAACTTGAATTTCCTTCCACAAATACAACCTTCAGCTCTTCCCTCTCTGTTTCCCTTTTGCCCACATTGCAAATAGTCTTCATAA
TAGAACCCTCACTGCAACTTAAAAGGGTCCCATTTCTTAACTCAGCATTTCATATACCAAGAACACTTGCAAAGATTTCTTCATAATGTG
ATTTTTTAATTTTTCAGTTCCAGAAGCATTTCCTACAGTTCGAACGTTATTTTTTCTCTCAGATTTTCAACTTGAAGCTTTGATTTGCAC
TGAATTAACTTGGATAAAATTTTAGTTTCTCTCTTCAGCTAACAGATTTGGAAGCAAATTACAGTATACTTGAATAATTCAGGTACTACC
TGTTGACCTGGAATTTTAGTGATTCTGGGAAAGTTTTCCAGACAAAGACACCAATAGAGTGAAGGGTTTTTTCCCCAATTACTATTTTAT
TGTTTTTTAAAATGCCTTTTTAAAACTTGTGTGATGTGGCAAAATAGTCATATGTTCAATTAATTTATATTTTATTCATTCCTTTTCAAT

>6734_6734_1_ARNT-CBLB_ARNT_chr1_150849019_ENST00000354396_CBLB_chr3_105439094_ENST00000264122_length(amino acids)=592AA_BP=11
MRPWRRLLPTPESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTS
PGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNR
LSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHL
GSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPS
SEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPG
SSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALE

--------------------------------------------------------------
>6734_6734_2_ARNT-CBLB_ARNT_chr1_150849019_ENST00000358595_CBLB_chr3_105439094_ENST00000264122_length(transcript)=5481nt_BP=226nt
ATATAGGCGGGGTCTCCCCGCCGCAGGGGCTGGGATGCTGGGGGCTGCTGAAGCCGCCATCTTGGATTCCGCGGTAGCGGAGGCGGCGGT
CAGGCGCCGCTTCTGGGGAGTGGCCTTTCTTTTCCCCTCCCTCCCGGTTCGGTGGCGGCGGCTCCTCCCACTGGGGGGGGGGGTGGCGCG
GCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGGAGTCGGATGGTCAGGGCTGCCCTTTCTGTCGTTGTGAAATAAA
AGGAACTGAGCCCATAATCGTGGACCCCTTTGATCCAAGAGATGAAGGCTCCAGGTGTTGCAGCATCATTGACCCCTTTGGCATGCCGAT
GCTAGACTTGGACGACGATGATGATCGTGAGGAGTCCTTGATGATGAATCGGTTGGCAAACGTCCGAAAGTGCACTGACAGGCAGAACTC
ACCAGTCACATCACCAGGATCCTCTCCCCTTGCCCAGAGAAGAAAGCCACAGCCTGACCCACTCCAGATCCCACATCTAAGCCTGCCACC
CGTGCCTCCTCGCCTGGATCTAATTCAGAAAGGCATAGTTAGATCTCCCTGTGGCAGCCCAACGGGTTCACCAAAGTCTTCTCCTTGCAT
GGTGAGAAAACAAGATAAACCACTCCCAGCACCACCTCCTCCCTTAAGAGATCCTCCTCCACCGCCACCTGAAAGACCTCCACCAATCCC
ACCAGACAATAGACTGAGTAGACACATCCATCATGTGGAAAGCGTGCCTTCCAGAGACCCGCCAATGCCTCTTGAAGCATGGTGCCCTCG
GGATGTGTTTGGGACTAATCAGCTTGTGGGATGTCGACTCCTAGGGGAGGGCTCTCCAAAACCTGGAATCACAGCGAGTTCAAATGTCAA
TGGAAGGCACAGTAGAGTGGGCTCTGACCCAGTGCTTATGCGGAAACACAGACGCCATGATTTGCCTTTAGAAGGAGCTAAGGTCTTTTC
CAATGGTCACCTTGGAAGTGAAGAATATGATGTTCCTCCCCGGCTTTCTCCTCCTCCTCCAGTTACCACCCTCCTCCCTAGCATAAAGTG
TACTGGTCCGTTAGCAAATTCTCTTTCAGAGAAAACAAGAGACCCAGTAGAGGAAGATGATGATGAATACAAGATTCCTTCATCCCACCC
TGTTTCCCTGAATTCACAACCATCTCATTGTCATAATGTAAAACCTCCTGTTCGGTCTTGTGATAATGGTCACTGTATGCTGAATGGAAC
ACATGGTCCATCTTCAGAGAAGAAATCAAACATCCCTGACTTAAGCATATATTTAAAGGGAGATGTTTTTGATTCAGCCTCTGATCCCGT
GCCATTACCACCTGCCAGGCCTCCAACTCGGGACAATCCAAAGCATGGTTCTTCACTCAACAGGACGCCCTCTGATTATGATCTTCTCAT
CCCTCCATTAGGTGAAGATGCTTTTGATGCCCTCCCTCCATCTCTCCCACCTCCCCCACCTCCTGCAAGGCATAGTCTCATTGAACATTC
AAAACCTCCTGGCTCCAGTAGCCGGCCATCCTCAGGACAGGATCTTTTTCTTCTTCCTTCAGATCCCTTTGTTGATCTAGCAAGTGGCCA
AGTTCCTTTGCCTCCTGCTAGAAGGTTACCAGGTGAAAATGTCAAAACTAACAGAACATCACAGGACTATGATCAGCTTCCTTCATGTTC
AGATGGTTCACAGGCACCAGCCAGACCCCCTAAACCACGACCGCGCAGGACTGCACCAGAAATTCACCACAGAAAACCCCATGGGCCTGA
GGCGGCATTGGAAAATGTCGATGCAAAAATTGCAAAACTCATGGGAGAGGGTTATGCCTTTGAAGAGGTGAAGAGAGCCTTAGAGATAGC
CCAGAATAATGTCGAAGTTGCCCGGAGCATCCTCCGAGAATTTGCCTTCCCTCCTCCAGTATCCCCACGTCTAAATCTATAGCAGCCAGA
ACTGTAGACACCAAAATGGAAAGCAATCGATGTATTCCAAGAGTGTGGAAATAAAGAGAACTGAGATGGAATTCAAGAGAGAAGTGTCTC
CTCCTCGTGTAGCAGCTTGAGAAGAGGCTTGGGAGTGCAGCTTCTCAAAGGAGACCGATGCTTGCTCAGGATGTCGACAGCTGTGGCTTC
CTTGTTTTTGCTAGCCATATTTTTAAATCAGGGTTGAACTGACAAAAATAATTTAAAGACGTTTACTTCCCTTGAACTTTGAACCTGTGA
AATGCTTTACCTTGTTTACAGTTTGGCAAAGTTGCAGTTTGTTCTTGTTTTTAGTTTAGTTTTGTTTTGGTGTTTTGATACCTGTACTGT
GTTCTTCACAGACCCTTTGTAGCGTGGTCAGGTCTGCTGTAACATTTCCCACCAACTCTCTTGCTGTCCACATCAACAGCTAAATCATTT
ATTCATATGGATCTCTACCATCCCCATGCCTTGCCCAGGTCCAGTTCCATTTCTCTCATTCACAAGATGCTTTGAAGGTTCTGATTTTCA
ACTGATCAAACTAATGCAAAAAAAAAAAAGTATGTATTCTTCACTACTGAGTTTCTTCTTTGGAAACCATCACTATTGAGAGATGGGAAA
AACCTGAATGTATAAAGCATTTATTTGTCAATAAACTGCCTTTTGTAAGGGGTTTTCACATAACATAGAGGAGCTTCCCTTTTTTGTTTA
AGTTTTGTAACCTTTAATCCTCCATATTCTCATGTCTGTCATCCCAGGGGTGTCACAACTGTAAAAATCTACAATATTAGAAAGCAGCTA
CTACAGATGTGGAAGAGAGAACACTTGTATAAGACAATGCTGTACTGAAGTTATATAACAAGGTCCCCTGATACTTATGCCTGCATTACT
TTGAGGGATGCTGAATGAGAGGACCATCTCCCTGAAATATATTAATAATTTTCAGATAAAATTATGAACATAACATACCTTTTCTCAAGT
GGAATTAGAGTTCATTTCCCATTTAAGTGATTACACTCTATCTCCTAAGAGCTGTGGGAACCAGTTCATATTGCAGTGGAAACATTAACT
CTTCGTTGCACTGTTGAGTGTCAAGGCTACTGTGGCAATGTTTTTTGCAAAGTTCTCAGTAATTTTCTCTCTGCAATCAAATTAGAGTTC
ATATTTAATTTGCAGATTCTCTCATTCATTGCTCCACACTGCTTTATCAAATCAGGTGAAAGAAATTAATGTAGTTTTGCCTATTTTACA
AAATGGTGGTTGGTTCTTTAAACACCATGTTATTACTCTTAATAAATCTACAAATATTTATTGAGCATCTATGATATGCTTGGTGCTGTT
AGGCACTGTGTTTTTAAAGCACAAACTCTCAAAAGCTGATTCCAGCGTAATGTTTTATTTTTGTTTTTCTGTGTTTTTTATGACAAAGTC
TGTCTGATAGACAAAGCCTGGAAGGTTTCCCCCAGGGCTTTAGAATTTAGAATTAGCTGGTTTTCATTTCAAATGGGAAATTAATGGAGA
AATGAGATAAAATCATCTCTGTGTAAATGCTTGAACCCACAGAAAGTTTTCTAAATATGGACTAATTGTGGGTTTGTGCATATTTCTGTG
TCTCCTCTTTTCACTTCACACCCACCATGATATAAAAAGATGCATCAGAGAGTGAGCCTGCCTTCAGGACCTGAAAGGACATGACTGAAC
ATCTAGTAGATCTGGTGGAAATTAATGTTATACAAAAGACACGTAGACTAAGTTGACCCTGGGAGAGGAGTTAATACATTCCTTTGCAAA
GTGACATGTGCCCTTTTTTTGACAGTCTGGCTTTCATGGTATGAGATGAGGACTCACAGGCCTTGGGTAATTTCTGCTTTTGTATGAATT
TTTTCAGATGGTTCTGAGCTGGTTATGTCCCTGGAGGGGAATTTTTCATTTGCCTTAGATGTTCTTCCCATGAGTAGGTACATGAGTGAA
GTTTCTTACACTTTTAAAATTGCATTGGCAAATTTTCTTTTGCTTTATGAACCCCTGTTTTGTCATTATGATTTTTCACTTGTTTTAACA
GTTTCAGATGTCACCTTGGAATAGCACTGTTTATTTTGGCCTTTTTATGATTGCTGATGATAGGTACAGTCTAAAGGCCAAAAGTTGCCA
CTTCATTGTGATAACATTGTTGCAACATTCCTAATATATTAGAGAATGATGTAAAATAAGAATGTTAGAGAACATAGCACATTCTCATTC
AGTTTATAAACAATATTTGAAAATTTCCAGTGAGAATTAAAAAAGGACTAGTGATGATATAGCAAACCTGGACCTGAAATTTGGGGGTGG
GGGGTGGGGGGATATCTGTTTTGCAGAGAAAATTTACCAGCCTCCAGCAAAATCTCTGCATCTTGTACTCAATAGCAACCATTAGTATTG
TCATTTAAAAAGAATGAATCAAAAATTCATACGTAATGGAATGAAAAGAGGAAAACTTTCTATTAAACACTGTCAAGAAAGACCCATTGC
TATCTATCACCTATGAAATTAAACCTAAAAAAATTTTTTTTTATTGTAAAAGCGACTGCTCGTTGATGTCTGGAAGTGATCCAGACTTTG
TTTCACTGTGATCCAAAAAGTTAGACATTCCTTCCATTTCTCAAGATTTGGTAACAATTTTTTTTTAAGTCAGCATTTCATATAATACAT
AAAATTAAGACAAATTAACTTACTGATATGTGGCCAATATCAACCCTTCTCACCCAACCCAAACATGTTCTGGAGATAGAAGGACTTATC
CTCAATTATATTCCAGTAAATTTATCTCCATAATCTGTTTTATCCCCTAATGTATGATATATCTCACCAAATTTTTCTAGAATTGAATAA
AAGCAGTTTTTGCTTAACTTGAATTTCCTTCCACAAATACAACCTTCAGCTCTTCCCTCTCTGTTTCCCTTTTGCCCACATTGCAAATAG
TCTTCATAATAGAACCCTCACTGCAACTTAAAAGGGTCCCATTTCTTAACTCAGCATTTCATATACCAAGAACACTTGCAAAGATTTCTT
CATAATGTGATTTTTTAATTTTTCAGTTCCAGAAGCATTTCCTACAGTTCGAACGTTATTTTTTCTCTCAGATTTTCAACTTGAAGCTTT
GATTTGCACTGAATTAACTTGGATAAAATTTTAGTTTCTCTCTTCAGCTAACAGATTTGGAAGCAAATTACAGTATACTTGAATAATTCA
GGTACTACCTGTTGACCTGGAATTTTAGTGATTCTGGGAAAGTTTTCCAGACAAAGACACCAATAGAGTGAAGGGTTTTTTCCCCAATTA
CTATTTTATTGTTTTTTAAAATGCCTTTTTAAAACTTGTGTGATGTGGCAAAATAGTCATATGTTCAATTAATTTATATTTTATTCATTC

>6734_6734_2_ARNT-CBLB_ARNT_chr1_150849019_ENST00000358595_CBLB_chr3_105439094_ENST00000264122_length(amino acids)=645AA_BP=64
MLGAAEAAILDSAVAEAAVRRRFWGVAFLFPSLPVRWRRLLPLGGGVARRRWHLRPWRRLLPTPESDGQGCPFCRCEIKGTEPIIVDPFD
PRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKG
IVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGC
RLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEK
TRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRD
NPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPG
ENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSIL

--------------------------------------------------------------
>6734_6734_3_ARNT-CBLB_ARNT_chr1_150849019_ENST00000505755_CBLB_chr3_105439094_ENST00000264122_length(transcript)=5322nt_BP=67nt
ACTGGGGGGGGGGGTGGCGCGGCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGGAGTCGGATGGTCAGGGCTGCCC
TTTCTGTCGTTGTGAAATAAAAGGAACTGAGCCCATAATCGTGGACCCCTTTGATCCAAGAGATGAAGGCTCCAGGTGTTGCAGCATCAT
TGACCCCTTTGGCATGCCGATGCTAGACTTGGACGACGATGATGATCGTGAGGAGTCCTTGATGATGAATCGGTTGGCAAACGTCCGAAA
GTGCACTGACAGGCAGAACTCACCAGTCACATCACCAGGATCCTCTCCCCTTGCCCAGAGAAGAAAGCCACAGCCTGACCCACTCCAGAT
CCCACATCTAAGCCTGCCACCCGTGCCTCCTCGCCTGGATCTAATTCAGAAAGGCATAGTTAGATCTCCCTGTGGCAGCCCAACGGGTTC
ACCAAAGTCTTCTCCTTGCATGGTGAGAAAACAAGATAAACCACTCCCAGCACCACCTCCTCCCTTAAGAGATCCTCCTCCACCGCCACC
TGAAAGACCTCCACCAATCCCACCAGACAATAGACTGAGTAGACACATCCATCATGTGGAAAGCGTGCCTTCCAGAGACCCGCCAATGCC
TCTTGAAGCATGGTGCCCTCGGGATGTGTTTGGGACTAATCAGCTTGTGGGATGTCGACTCCTAGGGGAGGGCTCTCCAAAACCTGGAAT
CACAGCGAGTTCAAATGTCAATGGAAGGCACAGTAGAGTGGGCTCTGACCCAGTGCTTATGCGGAAACACAGACGCCATGATTTGCCTTT
AGAAGGAGCTAAGGTCTTTTCCAATGGTCACCTTGGAAGTGAAGAATATGATGTTCCTCCCCGGCTTTCTCCTCCTCCTCCAGTTACCAC
CCTCCTCCCTAGCATAAAGTGTACTGGTCCGTTAGCAAATTCTCTTTCAGAGAAAACAAGAGACCCAGTAGAGGAAGATGATGATGAATA
CAAGATTCCTTCATCCCACCCTGTTTCCCTGAATTCACAACCATCTCATTGTCATAATGTAAAACCTCCTGTTCGGTCTTGTGATAATGG
TCACTGTATGCTGAATGGAACACATGGTCCATCTTCAGAGAAGAAATCAAACATCCCTGACTTAAGCATATATTTAAAGGGAGATGTTTT
TGATTCAGCCTCTGATCCCGTGCCATTACCACCTGCCAGGCCTCCAACTCGGGACAATCCAAAGCATGGTTCTTCACTCAACAGGACGCC
CTCTGATTATGATCTTCTCATCCCTCCATTAGGTGAAGATGCTTTTGATGCCCTCCCTCCATCTCTCCCACCTCCCCCACCTCCTGCAAG
GCATAGTCTCATTGAACATTCAAAACCTCCTGGCTCCAGTAGCCGGCCATCCTCAGGACAGGATCTTTTTCTTCTTCCTTCAGATCCCTT
TGTTGATCTAGCAAGTGGCCAAGTTCCTTTGCCTCCTGCTAGAAGGTTACCAGGTGAAAATGTCAAAACTAACAGAACATCACAGGACTA
TGATCAGCTTCCTTCATGTTCAGATGGTTCACAGGCACCAGCCAGACCCCCTAAACCACGACCGCGCAGGACTGCACCAGAAATTCACCA
CAGAAAACCCCATGGGCCTGAGGCGGCATTGGAAAATGTCGATGCAAAAATTGCAAAACTCATGGGAGAGGGTTATGCCTTTGAAGAGGT
GAAGAGAGCCTTAGAGATAGCCCAGAATAATGTCGAAGTTGCCCGGAGCATCCTCCGAGAATTTGCCTTCCCTCCTCCAGTATCCCCACG
TCTAAATCTATAGCAGCCAGAACTGTAGACACCAAAATGGAAAGCAATCGATGTATTCCAAGAGTGTGGAAATAAAGAGAACTGAGATGG
AATTCAAGAGAGAAGTGTCTCCTCCTCGTGTAGCAGCTTGAGAAGAGGCTTGGGAGTGCAGCTTCTCAAAGGAGACCGATGCTTGCTCAG
GATGTCGACAGCTGTGGCTTCCTTGTTTTTGCTAGCCATATTTTTAAATCAGGGTTGAACTGACAAAAATAATTTAAAGACGTTTACTTC
CCTTGAACTTTGAACCTGTGAAATGCTTTACCTTGTTTACAGTTTGGCAAAGTTGCAGTTTGTTCTTGTTTTTAGTTTAGTTTTGTTTTG
GTGTTTTGATACCTGTACTGTGTTCTTCACAGACCCTTTGTAGCGTGGTCAGGTCTGCTGTAACATTTCCCACCAACTCTCTTGCTGTCC
ACATCAACAGCTAAATCATTTATTCATATGGATCTCTACCATCCCCATGCCTTGCCCAGGTCCAGTTCCATTTCTCTCATTCACAAGATG
CTTTGAAGGTTCTGATTTTCAACTGATCAAACTAATGCAAAAAAAAAAAAGTATGTATTCTTCACTACTGAGTTTCTTCTTTGGAAACCA
TCACTATTGAGAGATGGGAAAAACCTGAATGTATAAAGCATTTATTTGTCAATAAACTGCCTTTTGTAAGGGGTTTTCACATAACATAGA
GGAGCTTCCCTTTTTTGTTTAAGTTTTGTAACCTTTAATCCTCCATATTCTCATGTCTGTCATCCCAGGGGTGTCACAACTGTAAAAATC
TACAATATTAGAAAGCAGCTACTACAGATGTGGAAGAGAGAACACTTGTATAAGACAATGCTGTACTGAAGTTATATAACAAGGTCCCCT
GATACTTATGCCTGCATTACTTTGAGGGATGCTGAATGAGAGGACCATCTCCCTGAAATATATTAATAATTTTCAGATAAAATTATGAAC
ATAACATACCTTTTCTCAAGTGGAATTAGAGTTCATTTCCCATTTAAGTGATTACACTCTATCTCCTAAGAGCTGTGGGAACCAGTTCAT
ATTGCAGTGGAAACATTAACTCTTCGTTGCACTGTTGAGTGTCAAGGCTACTGTGGCAATGTTTTTTGCAAAGTTCTCAGTAATTTTCTC
TCTGCAATCAAATTAGAGTTCATATTTAATTTGCAGATTCTCTCATTCATTGCTCCACACTGCTTTATCAAATCAGGTGAAAGAAATTAA
TGTAGTTTTGCCTATTTTACAAAATGGTGGTTGGTTCTTTAAACACCATGTTATTACTCTTAATAAATCTACAAATATTTATTGAGCATC
TATGATATGCTTGGTGCTGTTAGGCACTGTGTTTTTAAAGCACAAACTCTCAAAAGCTGATTCCAGCGTAATGTTTTATTTTTGTTTTTC
TGTGTTTTTTATGACAAAGTCTGTCTGATAGACAAAGCCTGGAAGGTTTCCCCCAGGGCTTTAGAATTTAGAATTAGCTGGTTTTCATTT
CAAATGGGAAATTAATGGAGAAATGAGATAAAATCATCTCTGTGTAAATGCTTGAACCCACAGAAAGTTTTCTAAATATGGACTAATTGT
GGGTTTGTGCATATTTCTGTGTCTCCTCTTTTCACTTCACACCCACCATGATATAAAAAGATGCATCAGAGAGTGAGCCTGCCTTCAGGA
CCTGAAAGGACATGACTGAACATCTAGTAGATCTGGTGGAAATTAATGTTATACAAAAGACACGTAGACTAAGTTGACCCTGGGAGAGGA
GTTAATACATTCCTTTGCAAAGTGACATGTGCCCTTTTTTTGACAGTCTGGCTTTCATGGTATGAGATGAGGACTCACAGGCCTTGGGTA
ATTTCTGCTTTTGTATGAATTTTTTCAGATGGTTCTGAGCTGGTTATGTCCCTGGAGGGGAATTTTTCATTTGCCTTAGATGTTCTTCCC
ATGAGTAGGTACATGAGTGAAGTTTCTTACACTTTTAAAATTGCATTGGCAAATTTTCTTTTGCTTTATGAACCCCTGTTTTGTCATTAT
GATTTTTCACTTGTTTTAACAGTTTCAGATGTCACCTTGGAATAGCACTGTTTATTTTGGCCTTTTTATGATTGCTGATGATAGGTACAG
TCTAAAGGCCAAAAGTTGCCACTTCATTGTGATAACATTGTTGCAACATTCCTAATATATTAGAGAATGATGTAAAATAAGAATGTTAGA
GAACATAGCACATTCTCATTCAGTTTATAAACAATATTTGAAAATTTCCAGTGAGAATTAAAAAAGGACTAGTGATGATATAGCAAACCT
GGACCTGAAATTTGGGGGTGGGGGGTGGGGGGATATCTGTTTTGCAGAGAAAATTTACCAGCCTCCAGCAAAATCTCTGCATCTTGTACT
CAATAGCAACCATTAGTATTGTCATTTAAAAAGAATGAATCAAAAATTCATACGTAATGGAATGAAAAGAGGAAAACTTTCTATTAAACA
CTGTCAAGAAAGACCCATTGCTATCTATCACCTATGAAATTAAACCTAAAAAAATTTTTTTTTATTGTAAAAGCGACTGCTCGTTGATGT
CTGGAAGTGATCCAGACTTTGTTTCACTGTGATCCAAAAAGTTAGACATTCCTTCCATTTCTCAAGATTTGGTAACAATTTTTTTTTAAG
TCAGCATTTCATATAATACATAAAATTAAGACAAATTAACTTACTGATATGTGGCCAATATCAACCCTTCTCACCCAACCCAAACATGTT
CTGGAGATAGAAGGACTTATCCTCAATTATATTCCAGTAAATTTATCTCCATAATCTGTTTTATCCCCTAATGTATGATATATCTCACCA
AATTTTTCTAGAATTGAATAAAAGCAGTTTTTGCTTAACTTGAATTTCCTTCCACAAATACAACCTTCAGCTCTTCCCTCTCTGTTTCCC
TTTTGCCCACATTGCAAATAGTCTTCATAATAGAACCCTCACTGCAACTTAAAAGGGTCCCATTTCTTAACTCAGCATTTCATATACCAA
GAACACTTGCAAAGATTTCTTCATAATGTGATTTTTTAATTTTTCAGTTCCAGAAGCATTTCCTACAGTTCGAACGTTATTTTTTCTCTC
AGATTTTCAACTTGAAGCTTTGATTTGCACTGAATTAACTTGGATAAAATTTTAGTTTCTCTCTTCAGCTAACAGATTTGGAAGCAAATT
ACAGTATACTTGAATAATTCAGGTACTACCTGTTGACCTGGAATTTTAGTGATTCTGGGAAAGTTTTCCAGACAAAGACACCAATAGAGT
GAAGGGTTTTTTCCCCAATTACTATTTTATTGTTTTTTAAAATGCCTTTTTAAAACTTGTGTGATGTGGCAAAATAGTCATATGTTCAAT
TAATTTATATTTTATTCATTCCTTTTCAATTCTGGTTATTATGTAACCTCAAGTACTTTATCTGTTCTTTTAAAGTATTTTATAAAATGA

>6734_6734_3_ARNT-CBLB_ARNT_chr1_150849019_ENST00000505755_CBLB_chr3_105439094_ENST00000264122_length(amino acids)=603AA_BP=22
LGGGVARRRWHLRPWRRLLPTPESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRK
CTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPP
ERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPL
EGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNG
HCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPAR
HSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHH

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Fusion Gene PPI Analysis for ARNT-CBLB

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	CBLB	chr1:150849019	chr3:105439094	ENST00000264122		8	19	891_927	401.0	983.0	SH3KBP1
Tgene	CBLB	chr1:150849019	chr3:105439094	ENST00000403724		8	15	891_927	401.0	771.0	SH3KBP1
Tgene	CBLB	chr1:150849019	chr3:105439094	ENST00000264122		8	19	543_568	401.0	983.0	VAV1
Tgene	CBLB	chr1:150849019	chr3:105439094	ENST00000403724		8	15	543_568	401.0	771.0	VAV1

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ARNT-CBLB

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ARNT-CBLB

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ARNT	C0000786	Spontaneous abortion	1	CTD_human
Hgene	ARNT	C0000822	Abortion, Tubal	1	CTD_human
Hgene	ARNT	C0009402	Colorectal Carcinoma	1	CTD_human
Hgene	ARNT	C0009404	Colorectal Neoplasms	1	CTD_human
Hgene	ARNT	C0014175	Endometriosis	1	CTD_human
Hgene	ARNT	C0019193	Hepatitis, Toxic	1	CTD_human
Hgene	ARNT	C0023452	Childhood Acute Lymphoblastic Leukemia	1	CTD_human
Hgene	ARNT	C0023453	L2 Acute Lymphoblastic Leukemia	1	CTD_human
Hgene	ARNT	C0023890	Liver Cirrhosis	1	CTD_human
Hgene	ARNT	C0025202	melanoma	1	CTD_human
Hgene	ARNT	C0027659	Neoplasms, Experimental	1	CTD_human
Hgene	ARNT	C0239946	Fibrosis, Liver	1	CTD_human
Hgene	ARNT	C0269102	Endometrioma	1	CTD_human
Hgene	ARNT	C0860207	Drug-Induced Liver Disease	1	CTD_human
Hgene	ARNT	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Hgene	ARNT	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	1	CTD_human
Hgene	ARNT	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Hgene	ARNT	C3830362	Early Pregnancy Loss	1	CTD_human
Hgene	ARNT	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Hgene	ARNT	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human
Hgene	ARNT	C4552766	Miscarriage	1	CTD_human
Tgene		C0014072	Experimental Autoimmune Encephalomyelitis	1	CTD_human
Tgene		C0026769	Multiple Sclerosis	1	CTD_human
Tgene		C0751324	Multiple Sclerosis, Acute Fulminating	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:ARNT-CBLB (FusionGDB2 ID:HG405TG868)

Fusion Gene Summary for ARNT-CBLB

Fusion Gene ORF analysis for ARNT-CBLB

Fusion Genomic Features for ARNT-CBLB

Fusion Protein Features for ARNT-CBLB

Fusion Gene Sequence for ARNT-CBLB

Fusion Gene PPI Analysis for ARNT-CBLB

Related Drugs for ARNT-CBLB

Related Diseases for ARNT-CBLB

Fusion Gene Studies
in Kim Lab