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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARRB1-TPCN2 (FusionGDB2 ID:HG408TG219931)

Fusion Gene Summary for ARRB1-TPCN2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARRB1-TPCN2
Fusion gene ID: hg408tg219931
HgeneTgene
Gene symbol

ARRB1

TPCN2

Gene ID

408

219931

Gene namearrestin beta 1two pore segment channel 2
SynonymsARB1|ARR1SHEP10|TPC2
Cytomap('ARRB1')('TPCN2')

11q13.4

11q13.3

Type of geneprotein-codingprotein-coding
Descriptionbeta-arrestin-1arrestin 2non-visual arrestin-2two pore calcium channel protein 2voltage-dependent calcium channel protein TPC2
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000360025, ENST00000393505, 
ENST00000420843, 
Fusion gene scores* DoF score18 X 10 X 9=162011 X 9 X 6=594
# samples 2312
** MAII scorelog2(23/1620*10)=-2.81628804682761
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/594*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARRB1 [Title/Abstract] AND TPCN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARRB1(74994331)-TPCN2(68845950), # samples:1
Anticipated loss of major functional domain due to fusion event.ARRB1-TPCN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARRB1-TPCN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARRB1-TPCN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARRB1-TPCN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARRB1

GO:0031397

negative regulation of protein ubiquitination

16378096

HgeneARRB1

GO:0032088

negative regulation of NF-kappaB transcription factor activity

16378096

HgeneARRB1

GO:0032715

negative regulation of interleukin-6 production

16378096

HgeneARRB1

GO:0032717

negative regulation of interleukin-8 production

16378096

HgeneARRB1

GO:0070374

positive regulation of ERK1 and ERK2 cascade

10644702

TgeneTPCN2

GO:0006874

cellular calcium ion homeostasis

19387438


check buttonFusion gene breakpoints across ARRB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TPCN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A109-01AARRB1chr11

74994331

-TPCN2chr11

68845950

+


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Fusion Gene ORF analysis for ARRB1-TPCN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000360025ENST00000442692ARRB1chr11

74994331

-TPCN2chr11

68845950

+
5CDS-3UTRENST00000393505ENST00000442692ARRB1chr11

74994331

-TPCN2chr11

68845950

+
5CDS-3UTRENST00000420843ENST00000442692ARRB1chr11

74994331

-TPCN2chr11

68845950

+
In-frameENST00000360025ENST00000294309ARRB1chr11

74994331

-TPCN2chr11

68845950

+
In-frameENST00000360025ENST00000542467ARRB1chr11

74994331

-TPCN2chr11

68845950

+
In-frameENST00000393505ENST00000294309ARRB1chr11

74994331

-TPCN2chr11

68845950

+
In-frameENST00000393505ENST00000542467ARRB1chr11

74994331

-TPCN2chr11

68845950

+
In-frameENST00000420843ENST00000294309ARRB1chr11

74994331

-TPCN2chr11

68845950

+
In-frameENST00000420843ENST00000542467ARRB1chr11

74994331

-TPCN2chr11

68845950

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000420843ARRB1chr1174994331-ENST00000294309TPCN2chr1168845950+2052452321480482
ENST00000420843ARRB1chr1174994331-ENST00000542467TPCN2chr1168845950+118545210302343
ENST00000393505ARRB1chr1174994331-ENST00000294309TPCN2chr1168845950+2176576211604527
ENST00000393505ARRB1chr1174994331-ENST00000542467TPCN2chr1168845950+130957611540385
ENST00000360025ARRB1chr1174994331-ENST00000294309TPCN2chr1168845950+2052452321480482
ENST00000360025ARRB1chr1174994331-ENST00000542467TPCN2chr1168845950+118545210302343

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000420843ENST00000294309ARRB1chr1174994331-TPCN2chr1168845950+0.0054584040.9945416
ENST00000420843ENST00000542467ARRB1chr1174994331-TPCN2chr1168845950+0.0118732210.98812675
ENST00000393505ENST00000294309ARRB1chr1174994331-TPCN2chr1168845950+0.0055339080.9944661
ENST00000393505ENST00000542467ARRB1chr1174994331-TPCN2chr1168845950+0.0086269470.99137306
ENST00000360025ENST00000294309ARRB1chr1174994331-TPCN2chr1168845950+0.0054584040.9945416
ENST00000360025ENST00000542467ARRB1chr1174994331-TPCN2chr1168845950+0.0118732210.98812675

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Fusion Genomic Features for ARRB1-TPCN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARRB1chr1174994330-TPCN2chr1168845949+1.68E-050.9999832
ARRB1chr1174994330-TPCN2chr1168845949+1.68E-050.9999832

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARRB1-TPCN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:74994331/chr11:68845950)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225636_658410753.0IntramembraneHelical%3B Pore-forming
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225460_465410753.0Topological domainExtracellular
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225487_502410753.0Topological domainCytoplasmic
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225524_554410753.0Topological domainExtracellular
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225576_580410753.0Topological domainCytoplasmic
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225602_635410753.0Topological domainExtracellular
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225659_673410753.0Topological domainExtracellular
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225695_752410753.0Topological domainCytoplasmic
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225437_459410753.0TransmembraneHelical%3B Name%3DS1 of repeat II
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225466_486410753.0TransmembraneHelical%3B Name%3DS2 of repeat II
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225503_523410753.0TransmembraneHelical%3B Name%3DS3 of repeat II
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225555_575410753.0TransmembraneHelical%3B Name%3DS4 of repeat II
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225581_601410753.0TransmembraneHelical%3B Name%3DS5 of repeat II
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225674_694410753.0TransmembraneHelical%3B Name%3DS6 of repeat II

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARRB1chr11:74994331chr11:68845950ENST00000360025-515385_395118411.0MotifNote=[DE]-X(1%2C2)-F-X-X-[FL]-X-X-X-R motif
HgeneARRB1chr11:74994331chr11:68845950ENST00000420843-516385_395118419.0MotifNote=[DE]-X(1%2C2)-F-X-X-[FL]-X-X-X-R motif
TgeneTPCN2chr11:74994331chr11:68845950ENST00000294309122517_20410753.0Compositional biasNote=Poly-Gly
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225255_279410753.0IntramembraneHelical%3B Pore-forming
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225106_127410753.0Topological domainExtracellular
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225149_155410753.0Topological domainCytoplasmic
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225177_183410753.0Topological domainExtracellular
TgeneTPCN2chr11:74994331chr11:68845950ENST0000029430912251_84410753.0Topological domainCytoplasmic
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225205_218410753.0Topological domainCytoplasmic
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225240_254410753.0Topological domainExtracellular
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225280_289410753.0Topological domainExtracellular
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225311_436410753.0Topological domainCytoplasmic
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225128_148410753.0TransmembraneHelical%3B Name%3DS2 of repeat I
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225156_176410753.0TransmembraneHelical%3B Name%3DS3 of repeat I
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225184_204410753.0TransmembraneHelical%3B Name%3DS4 of repeat I
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225219_239410753.0TransmembraneHelical%3B Name%3DS5 of repeat I
TgeneTPCN2chr11:74994331chr11:68845950ENST000002943091225290_310410753.0TransmembraneHelical%3B Name%3DS6 of repeat I
TgeneTPCN2chr11:74994331chr11:68845950ENST00000294309122585_105410753.0TransmembraneHelical%3B Name%3DS1 of repeat I


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Fusion Gene Sequence for ARRB1-TPCN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6848_6848_1_ARRB1-TPCN2_ARRB1_chr11_74994331_ENST00000360025_TPCN2_chr11_68845950_ENST00000294309_length(transcript)=2052nt_BP=452nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGAGTGTTCAAGAAGGCCAGTCCAAATGGAAAGCTCACCGTCTACCTGGGAAAGCGGGACTTTG
TGGACCACATCGACCTCGTGGACCCTGTGGATGGTGTGGTCCTGGTGGATCCTGAGTATCTCAAAGAGCGGAGAGTCTATGTGACGCTGA
CCTGCGCCTTCCGCTATGGCCGGGAGGACCTGGATGTCCTGGGCCTGACCTTTCGCAAGGACCTGTTTGTGGCCAACGTACAGTCGTTCC
CACCGGCCCCCGAGGACAAGAAGCCCCTGACGCGGCTGCAGGAACGCCTCATCAAGAAGCTGGGCGAGCACGCTTACCCTTTCACCTTTG
AGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACC
TCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGG
GGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACC
CCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTGGCTGTGTACCGATTGCCACACCCAGGCT
GGAGGCCGGAGATGGTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCC
CCAGCATGAAGCTGATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGTGCGTTTGGCGGGATCCTGGTGGTGGTCT
ACTACGTATTTGCCATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCT
CGGCGCCCTGTGGGAGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCGGCTGCCCTGGTCACTCTGTGGAACTTGA
TGGTGGTGAACAACTGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGG
TGTCGTCTGTCATCTGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCC
TTGCTGGGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAG
AGAGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCT
ACACAGGTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGAC
AGGAACCAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTT
ATAGCTGCTTCAGTGAGAATTCCCTCGTCGACTCCACAGGGACCTTTCAGACAAAAATGCAAGAAGCAGCGGCCTCCCCTGTCCCCTGCA
GCTTCCGTGGTGCCTTTGCTGCCGGCAGCCCTTGGGGACCACAGGCCTGACCAGGGCCTGCACAGGTTAACCGTCAGACTTCCGGGGCAT
TCAGGTGGGGATGCTGGTGGTTTGACATGGAGAGAACCTTGACTGTGTTTTATTATTTCATGGCTTGTATGAGTGTGACTGGGTGTGTTT

>6848_6848_1_ARRB1-TPCN2_ARRB1_chr11_74994331_ENST00000360025_TPCN2_chr11_68845950_ENST00000294309_length(amino acids)=482AA_BP=140
MLAGDFPAWALTPRTSLRPSRTMGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDL
DVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSIC
VFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL
WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLE
YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM

--------------------------------------------------------------
>6848_6848_2_ARRB1-TPCN2_ARRB1_chr11_74994331_ENST00000360025_TPCN2_chr11_68845950_ENST00000542467_length(transcript)=1185nt_BP=452nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGAGTGTTCAAGAAGGCCAGTCCAAATGGAAAGCTCACCGTCTACCTGGGAAAGCGGGACTTTG
TGGACCACATCGACCTCGTGGACCCTGTGGATGGTGTGGTCCTGGTGGATCCTGAGTATCTCAAAGAGCGGAGAGTCTATGTGACGCTGA
CCTGCGCCTTCCGCTATGGCCGGGAGGACCTGGATGTCCTGGGCCTGACCTTTCGCAAGGACCTGTTTGTGGCCAACGTACAGTCGTTCC
CACCGGCCCCCGAGGACAAGAAGCCCCTGACGCGGCTGCAGGAACGCCTCATCAAGAAGCTGGGCGAGCACGCTTACCCTTTCACCTTTG
AGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACC
TCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGG
GGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACC
CCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTG
GGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGC
TGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAG
GTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAAC
CAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCT

>6848_6848_2_ARRB1-TPCN2_ARRB1_chr11_74994331_ENST00000360025_TPCN2_chr11_68845950_ENST00000542467_length(amino acids)=343AA_BP=1
MAGHSMAASSMTGTCVGQPLSPAAPAGTAARTSPAQPQVRVLAQPLCELILPGLLQNIPEQELHSHLVGGLWGPSKGLQVAAGVPLVKEV
QQDNGEEPVKHVAGVGQVPSQAQGKDLEQHLQQVVHNEDAVENPQDEVITLSRQHICIQHQEHANGHQVCQGDEVPQVVKVVVAEEELGA
LQKRRLVLGPRRVLKGERVSVLAQLLDEAFLQPRQGLLVLGGRWERLYVGHKQVLAKGQAQDIQVLPAIAEGAGQRHIDSPLFEILRIHQ

--------------------------------------------------------------
>6848_6848_3_ARRB1-TPCN2_ARRB1_chr11_74994331_ENST00000393505_TPCN2_chr11_68845950_ENST00000294309_length(transcript)=2176nt_BP=576nt
ACCCCGCGCGGTTCCACGCCCCTGGCCGCGGCCCGGGCGCTGCGCTGCTCGACGCGGCGGGCGGCGGGCGGGGACCGGGGGCGGGGGCGG
CGGCGGCGGCCGGGAGAGCGGAGGAGGCGGAGCAGGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCC
TGGGCGCTGACGCCGCGGACCTCCCTGCGACCGTCGCGGACCATGGGCGACAAAGGGACCCGAGTGTTCAAGAAGGCCAGTCCAAATGGA
AAGCTCACCGTCTACCTGGGAAAGCGGGACTTTGTGGACCACATCGACCTCGTGGACCCTGTGGATGGTGTGGTCCTGGTGGATCCTGAG
TATCTCAAAGAGCGGAGAGTCTATGTGACGCTGACCTGCGCCTTCCGCTATGGCCGGGAGGACCTGGATGTCCTGGGCCTGACCTTTCGC
AAGGACCTGTTTGTGGCCAACGTACAGTCGTTCCCACCGGCCCCCGAGGACAAGAAGCCCCTGACGCGGCTGCAGGAACGCCTCATCAAG
AAGCTGGGCGAGCACGCTTACCCTTTCACCTTTGAGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTC
TTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGAT
GTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTC
TTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCA
ACTCTGGCTGTGTACCGATTGCCACACCCAGGCTGGAGGCCGGAGATGGTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTGAAC
ATGCTCATCGTGTTCCGCTTCCTGCGTATCATCCCCAGCATGAAGCTGATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAAC
ATGCGTGCGTTTGGCGGGATCCTGGTGGTGGTCTACTACGTATTTGCCATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCTCTT
CCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCTCGGCGCCCTGTGGGAGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGAC
TTTGCGGCTGCCCTGGTCACTCTGTGGAACTTGATGGTGGTGAACAACTGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGCCCG
TGGTCCAAGATCTATTTTGTATTGTGGTGGCTGGTGTCGTCTGTCATCTGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTT
CACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGAT
ATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGT
CCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGGTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGA
GACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACCAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTG
CTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCTGCTTCAGTGAGAATTCCCTCGTCGACTCCACAGGGACCTTTCAGACAAAA
ATGCAAGAAGCAGCGGCCTCCCCTGTCCCCTGCAGCTTCCGTGGTGCCTTTGCTGCCGGCAGCCCTTGGGGACCACAGGCCTGACCAGGG
CCTGCACAGGTTAACCGTCAGACTTCCGGGGCATTCAGGTGGGGATGCTGGTGGTTTGACATGGAGAGAACCTTGACTGTGTTTTATTAT
TTCATGGCTTGTATGAGTGTGACTGGGTGTGTTTCTTTAGGGTTCTGATTGCCAGTTATTTTCATCAATAAGTCTTGCAAAGAATGGGAT

>6848_6848_3_ARRB1-TPCN2_ARRB1_chr11_74994331_ENST00000393505_TPCN2_chr11_68845950_ENST00000294309_length(amino acids)=527AA_BP=185
MAAARALRCSTRRAAGGDRGRGRRRRPGERRRRSREPGAGWPALLLLAGDFPAWALTPRTSLRPSRTMGDKGTRVFKKASPNGKLTVYLG
KRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAY
PFTFEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG
YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI
LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFV

--------------------------------------------------------------
>6848_6848_4_ARRB1-TPCN2_ARRB1_chr11_74994331_ENST00000393505_TPCN2_chr11_68845950_ENST00000542467_length(transcript)=1309nt_BP=576nt
ACCCCGCGCGGTTCCACGCCCCTGGCCGCGGCCCGGGCGCTGCGCTGCTCGACGCGGCGGGCGGCGGGCGGGGACCGGGGGCGGGGGCGG
CGGCGGCGGCCGGGAGAGCGGAGGAGGCGGAGCAGGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCC
TGGGCGCTGACGCCGCGGACCTCCCTGCGACCGTCGCGGACCATGGGCGACAAAGGGACCCGAGTGTTCAAGAAGGCCAGTCCAAATGGA
AAGCTCACCGTCTACCTGGGAAAGCGGGACTTTGTGGACCACATCGACCTCGTGGACCCTGTGGATGGTGTGGTCCTGGTGGATCCTGAG
TATCTCAAAGAGCGGAGAGTCTATGTGACGCTGACCTGCGCCTTCCGCTATGGCCGGGAGGACCTGGATGTCCTGGGCCTGACCTTTCGC
AAGGACCTGTTTGTGGCCAACGTACAGTCGTTCCCACCGGCCCCCGAGGACAAGAAGCCCCTGACGCGGCTGCAGGAACGCCTCATCAAG
AAGCTGGGCGAGCACGCTTACCCTTTCACCTTTGAGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTC
TTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGAT
GTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTC
TTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCACAAG
TGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTG
GAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGC
AGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGGTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTT
TCCTCTGACGGACCACTAAGCTGGGGACAGGAACCAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAG

>6848_6848_4_ARRB1-TPCN2_ARRB1_chr11_74994331_ENST00000393505_TPCN2_chr11_68845950_ENST00000542467_length(amino acids)=385AA_BP=1
MAGHSMAASSMTGTCVGQPLSPAAPAGTAARTSPAQPQVRVLAQPLCELILPGLLQNIPEQELHSHLVGGLWGPSKGLQVAAGVPLVKEV
QQDNGEEPVKHVAGVGQVPSQAQGKDLEQHLQQVVHNEDAVENPQDEVITLSRQHICIQHQEHANGHQVCQGDEVPQVVKVVVAEEELGA
LQKRRLVLGPRRVLKGERVSVLAQLLDEAFLQPRQGLLVLGGRWERLYVGHKQVLAKGQAQDIQVLPAIAEGAGQRHIDSPLFEILRIHQ
DHTIHRVHEVDVVHKVPLSQVDGELSIWTGLLEHSGPFVAHGPRRSQGGPRRQRPGWKIPSQQEERGPARSRLPAPPPPLSRPPPPPPPP

--------------------------------------------------------------
>6848_6848_5_ARRB1-TPCN2_ARRB1_chr11_74994331_ENST00000420843_TPCN2_chr11_68845950_ENST00000294309_length(transcript)=2052nt_BP=452nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGAGTGTTCAAGAAGGCCAGTCCAAATGGAAAGCTCACCGTCTACCTGGGAAAGCGGGACTTTG
TGGACCACATCGACCTCGTGGACCCTGTGGATGGTGTGGTCCTGGTGGATCCTGAGTATCTCAAAGAGCGGAGAGTCTATGTGACGCTGA
CCTGCGCCTTCCGCTATGGCCGGGAGGACCTGGATGTCCTGGGCCTGACCTTTCGCAAGGACCTGTTTGTGGCCAACGTACAGTCGTTCC
CACCGGCCCCCGAGGACAAGAAGCCCCTGACGCGGCTGCAGGAACGCCTCATCAAGAAGCTGGGCGAGCACGCTTACCCTTTCACCTTTG
AGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACC
TCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGG
GGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACC
CCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTGGCTGTGTACCGATTGCCACACCCAGGCT
GGAGGCCGGAGATGGTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCC
CCAGCATGAAGCTGATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGTGCGTTTGGCGGGATCCTGGTGGTGGTCT
ACTACGTATTTGCCATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCT
CGGCGCCCTGTGGGAGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCGGCTGCCCTGGTCACTCTGTGGAACTTGA
TGGTGGTGAACAACTGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGG
TGTCGTCTGTCATCTGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCC
TTGCTGGGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAG
AGAGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCT
ACACAGGTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGAC
AGGAACCAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTT
ATAGCTGCTTCAGTGAGAATTCCCTCGTCGACTCCACAGGGACCTTTCAGACAAAAATGCAAGAAGCAGCGGCCTCCCCTGTCCCCTGCA
GCTTCCGTGGTGCCTTTGCTGCCGGCAGCCCTTGGGGACCACAGGCCTGACCAGGGCCTGCACAGGTTAACCGTCAGACTTCCGGGGCAT
TCAGGTGGGGATGCTGGTGGTTTGACATGGAGAGAACCTTGACTGTGTTTTATTATTTCATGGCTTGTATGAGTGTGACTGGGTGTGTTT

>6848_6848_5_ARRB1-TPCN2_ARRB1_chr11_74994331_ENST00000420843_TPCN2_chr11_68845950_ENST00000294309_length(amino acids)=482AA_BP=140
MLAGDFPAWALTPRTSLRPSRTMGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDL
DVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSIC
VFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL
WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLE
YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM

--------------------------------------------------------------
>6848_6848_6_ARRB1-TPCN2_ARRB1_chr11_74994331_ENST00000420843_TPCN2_chr11_68845950_ENST00000542467_length(transcript)=1185nt_BP=452nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGAGTGTTCAAGAAGGCCAGTCCAAATGGAAAGCTCACCGTCTACCTGGGAAAGCGGGACTTTG
TGGACCACATCGACCTCGTGGACCCTGTGGATGGTGTGGTCCTGGTGGATCCTGAGTATCTCAAAGAGCGGAGAGTCTATGTGACGCTGA
CCTGCGCCTTCCGCTATGGCCGGGAGGACCTGGATGTCCTGGGCCTGACCTTTCGCAAGGACCTGTTTGTGGCCAACGTACAGTCGTTCC
CACCGGCCCCCGAGGACAAGAAGCCCCTGACGCGGCTGCAGGAACGCCTCATCAAGAAGCTGGGCGAGCACGCTTACCCTTTCACCTTTG
AGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACC
TCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGG
GGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACC
CCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTG
GGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGC
TGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAG
GTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAAC
CAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCT

>6848_6848_6_ARRB1-TPCN2_ARRB1_chr11_74994331_ENST00000420843_TPCN2_chr11_68845950_ENST00000542467_length(amino acids)=343AA_BP=1
MAGHSMAASSMTGTCVGQPLSPAAPAGTAARTSPAQPQVRVLAQPLCELILPGLLQNIPEQELHSHLVGGLWGPSKGLQVAAGVPLVKEV
QQDNGEEPVKHVAGVGQVPSQAQGKDLEQHLQQVVHNEDAVENPQDEVITLSRQHICIQHQEHANGHQVCQGDEVPQVVKVVVAEEELGA
LQKRRLVLGPRRVLKGERVSVLAQLLDEAFLQPRQGLLVLGGRWERLYVGHKQVLAKGQAQDIQVLPAIAEGAGQRHIDSPLFEILRIHQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARRB1-TPCN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneARRB1chr11:74994331chr11:68845950ENST00000360025-51545_86118.0411.0CHRM2
HgeneARRB1chr11:74994331chr11:68845950ENST00000420843-51645_86118.0419.0CHRM2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneARRB1chr11:74994331chr11:68845950ENST00000360025-5151_163118.0411.0SRC
HgeneARRB1chr11:74994331chr11:68845950ENST00000420843-5161_163118.0419.0SRC
HgeneARRB1chr11:74994331chr11:68845950ENST00000360025-515318_418118.0411.0TRAF6
HgeneARRB1chr11:74994331chr11:68845950ENST00000420843-516318_418118.0419.0TRAF6


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARRB1-TPCN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARRB1-TPCN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARRB1C0023890Liver Cirrhosis1CTD_human
HgeneARRB1C0041696Unipolar Depression1PSYGENET
HgeneARRB1C0239946Fibrosis, Liver1CTD_human
HgeneARRB1C1269683Major Depressive Disorder1PSYGENET
HgeneARRB1C3178803Social Anhedonia1PSYGENET