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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARRB1-PRCP (FusionGDB2 ID:HG408TG5547)

Fusion Gene Summary for ARRB1-PRCP

Fusion gene summary

Fusion gene information	Fusion gene name: ARRB1-PRCP
	Fusion gene ID: hg408tg5547
		Hgene	Tgene
	Gene symbol	ARRB1	PRCP
	Gene ID	408	5547
	Gene name	arrestin beta 1	prolylcarboxypeptidase
	Synonyms	ARB1\|ARR1	HUMPCP\|PCP
	Cytomap	('ARRB1')('PRCP') 11q13.4	11q14.1
	Type of gene	protein-coding	protein-coding
	Description	beta-arrestin-1arrestin 2non-visual arrestin-2	lysosomal Pro-X carboxypeptidaseangiotensinase Clysosomal carboxypeptidase Cproline carboxypeptidase
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000360025, ENST00000393505, ENST00000420843,
Fusion gene scores	* DoF score	18 X 10 X 9=1620	9 X 8 X 6=432
	# samples	23	11
	** MAII score	log2(23/1620*10)=-2.81628804682761 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/432*10)=-1.97352778863881 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ARRB1 [Title/Abstract] AND PRCP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARRB1(75062632)-PRCP(82550467), # samples:2
Anticipated loss of major functional domain due to fusion event.	ARRB1-PRCP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARRB1-PRCP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ARRB1	GO:0031397	negative regulation of protein ubiquitination	16378096
Hgene	ARRB1	GO:0032088	negative regulation of NF-kappaB transcription factor activity	16378096
Hgene	ARRB1	GO:0032715	negative regulation of interleukin-6 production	16378096
Hgene	ARRB1	GO:0032717	negative regulation of interleukin-8 production	16378096
Hgene	ARRB1	GO:0070374	positive regulation of ERK1 and ERK2 cascade	10644702

Fusion gene breakpoints across ARRB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PRCP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-EE-A2GR-06A	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-
ChimerDB4	SKCM	TCGA-EE-A2GR-06A	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-

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Fusion Gene ORF analysis for ARRB1-PRCP

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000360025	ENST00000525772	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-
5CDS-5UTR	ENST00000360025	ENST00000525772	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-
5CDS-5UTR	ENST00000393505	ENST00000525772	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-
5CDS-5UTR	ENST00000393505	ENST00000525772	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-
5CDS-5UTR	ENST00000420843	ENST00000525772	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-
5CDS-5UTR	ENST00000420843	ENST00000525772	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-
In-frame	ENST00000360025	ENST00000313010	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-
In-frame	ENST00000360025	ENST00000313010	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-
In-frame	ENST00000360025	ENST00000393399	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-
In-frame	ENST00000360025	ENST00000393399	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-
In-frame	ENST00000360025	ENST00000535099	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-
In-frame	ENST00000360025	ENST00000535099	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-
In-frame	ENST00000393505	ENST00000313010	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-
In-frame	ENST00000393505	ENST00000313010	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-
In-frame	ENST00000393505	ENST00000393399	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-
In-frame	ENST00000393505	ENST00000393399	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-
In-frame	ENST00000393505	ENST00000535099	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-
In-frame	ENST00000393505	ENST00000535099	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-
In-frame	ENST00000420843	ENST00000313010	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-
In-frame	ENST00000420843	ENST00000313010	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-
In-frame	ENST00000420843	ENST00000393399	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-
In-frame	ENST00000420843	ENST00000393399	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-
In-frame	ENST00000420843	ENST00000535099	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-
In-frame	ENST00000420843	ENST00000535099	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000420843	ARRB1	chr11	75062632	-	ENST00000313010	PRCP	chr11	82549616	-	1927	118	16	522	168
ENST00000420843	ARRB1	chr11	75062632	-	ENST00000393399	PRCP	chr11	82549616	-	1061	118	16	522	168
ENST00000420843	ARRB1	chr11	75062632	-	ENST00000535099	PRCP	chr11	82549616	-	639	118	16	522	168
ENST00000393505	ARRB1	chr11	75062632	-	ENST00000313010	PRCP	chr11	82549616	-	2051	242	44	646	200
ENST00000393505	ARRB1	chr11	75062632	-	ENST00000393399	PRCP	chr11	82549616	-	1185	242	44	646	200
ENST00000393505	ARRB1	chr11	75062632	-	ENST00000535099	PRCP	chr11	82549616	-	763	242	44	646	200
ENST00000360025	ARRB1	chr11	75062632	-	ENST00000313010	PRCP	chr11	82549616	-	1927	118	16	522	168
ENST00000360025	ARRB1	chr11	75062632	-	ENST00000393399	PRCP	chr11	82549616	-	1061	118	16	522	168
ENST00000360025	ARRB1	chr11	75062632	-	ENST00000535099	PRCP	chr11	82549616	-	639	118	16	522	168
ENST00000420843	ARRB1	chr11	75062632	-	ENST00000313010	PRCP	chr11	82550467	-	2092	118	16	687	223
ENST00000420843	ARRB1	chr11	75062632	-	ENST00000393399	PRCP	chr11	82550467	-	1226	118	16	687	223
ENST00000420843	ARRB1	chr11	75062632	-	ENST00000535099	PRCP	chr11	82550467	-	804	118	16	687	223
ENST00000393505	ARRB1	chr11	75062632	-	ENST00000313010	PRCP	chr11	82550467	-	2216	242	44	811	255
ENST00000393505	ARRB1	chr11	75062632	-	ENST00000393399	PRCP	chr11	82550467	-	1350	242	44	811	255
ENST00000393505	ARRB1	chr11	75062632	-	ENST00000535099	PRCP	chr11	82550467	-	928	242	44	811	255
ENST00000360025	ARRB1	chr11	75062632	-	ENST00000313010	PRCP	chr11	82550467	-	2092	118	16	687	223
ENST00000360025	ARRB1	chr11	75062632	-	ENST00000393399	PRCP	chr11	82550467	-	1226	118	16	687	223
ENST00000360025	ARRB1	chr11	75062632	-	ENST00000535099	PRCP	chr11	82550467	-	804	118	16	687	223

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000420843	ENST00000313010	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-	0.061036192	0.93896383
ENST00000420843	ENST00000393399	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-	0.055471014	0.94452894
ENST00000420843	ENST00000535099	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-	0.017895248	0.9821047
ENST00000393505	ENST00000313010	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-	0.023207936	0.97679204
ENST00000393505	ENST00000393399	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-	0.028480252	0.97151977
ENST00000393505	ENST00000535099	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-	0.01989625	0.98010373
ENST00000360025	ENST00000313010	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-	0.061036192	0.93896383
ENST00000360025	ENST00000393399	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-	0.055471014	0.94452894
ENST00000360025	ENST00000535099	ARRB1	chr11	75062632	-	PRCP	chr11	82549616	-	0.017895248	0.9821047
ENST00000420843	ENST00000313010	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-	0.043498747	0.95650125
ENST00000420843	ENST00000393399	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-	0.036736496	0.9632635
ENST00000420843	ENST00000535099	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-	0.019402849	0.9805972
ENST00000393505	ENST00000313010	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-	0.019871537	0.98012847
ENST00000393505	ENST00000393399	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-	0.028374655	0.9716253
ENST00000393505	ENST00000535099	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-	0.017121984	0.98287797
ENST00000360025	ENST00000313010	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-	0.043498747	0.95650125
ENST00000360025	ENST00000393399	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-	0.036736496	0.9632635
ENST00000360025	ENST00000535099	ARRB1	chr11	75062632	-	PRCP	chr11	82550467	-	0.019402849	0.9805972

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Fusion Genomic Features for ARRB1-PRCP

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for ARRB1-PRCP

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:75062632/chr11:82550467)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARRB1

chr11:75062632

chr11:82549616

ENST00000360025

385_395

411.0

Motif

Note=[DE]-X(1%2C2)-F-X-X-[FL]-X-X-X-R motif

Hgene

ARRB1

chr11:75062632

chr11:82549616

ENST00000420843

385_395

419.0

Motif

Note=[DE]-X(1%2C2)-F-X-X-[FL]-X-X-X-R motif

Hgene

ARRB1

chr11:75062632

chr11:82550467

ENST00000360025

385_395

411.0

Motif

Note=[DE]-X(1%2C2)-F-X-X-[FL]-X-X-X-R motif

Hgene

ARRB1

chr11:75062632

chr11:82550467

ENST00000420843

385_395

419.0

Motif

Note=[DE]-X(1%2C2)-F-X-X-[FL]-X-X-X-R motif

Tgene

PRCP

chr11:75062632

chr11:82549616

ENST00000313010

194_334

362

497.0

Region

Note=SKS domain

Tgene

PRCP

chr11:75062632

chr11:82549616

ENST00000393399

194_334

383

518.0

Region

Note=SKS domain

Tgene

PRCP

chr11:75062632

chr11:82550467

ENST00000313010

194_334

307

497.0

Region

Note=SKS domain

Tgene

PRCP

chr11:75062632

chr11:82550467

ENST00000393399

194_334

328

518.0

Region

Note=SKS domain

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Fusion Gene Sequence for ARRB1-PRCP

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>6845_6845_1_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000360025_PRCP_chr11_82549616_ENST00000313010_length(transcript)=1927nt_BP=118nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCGATGACATGTTTGAACCTCA
CTCATGGAACTTAAAGGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGATCACTACTATGTATGGAGG
CAAAAACATTAGTTCACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAGTAACTAAGGATATCACAGA
CACTCTGGTTGCAGTCACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATCCTATGTCTGTGCTGTTAGC
CCGCTCCTTGGAAGTTAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACTGAGAAACTTTTGATTGTTT
TCAATTTCTTCTTTTATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCTTTTGTTTATCATTAGATTT
GATGGGGCCAAAGTTGAGATAGAATAGAGGGTGATGACGGTAAGAGCAAGTGTCCCATGAATGTGATTTCCTGGGTTCTCACTGTCTTTG
CACCACGTCTAGGAAGAATCTTCTTGATAGCTCTCCCACACCATCAGTGGCCCTCATAACTGGAGTAGAGTTCCTGGTTGCTTTTCATAA
GAGGGAGAGTTACTTTCTTTGTATCTCTGCAAGCAGAGATTTCTCTTTGGTTTTGAGGTTGAAGTGTCTTTGGCCCATTTGTAAGTCCCC
ATCCCTACCCTACACAAAGTAAAAGCAGAAGATAGATAAAAAATGATGTAATTGCAGCTGGTAGGATGTCTGGTGCCAATCCAGGAAGTG
AGAGCCATTTCTTTTGTACCGGATTTAATGACTTTGAACTGTGCTGTAAATAAATAATACAGCTGGACCTTATACCTGTGTGTTGCTTCT
GAAGCTCACTTCAACTCCGGCTGATGGAAATGCTGTGTGCACTGGGCTTAGCTGTTTTTGGAAAGTCCTTTAATTTTTTCTCTTCCACTT
GGCAGCTTTTCTTAGTTCTGGGATGTTGGCCACTGTGGTACTGCCAGTAAGAAATCTGGCCTTTTTCTGCTCCATTTCTCTTTGTTTCTA
AGGTCAGTTTTAATTTGTTTGAATTCTGCCAGTTTAGGAAAATGACTCTGTTTTGTCTTTTTAAATCTGAGCAAGCTTTATGCTGTAGTC
ACTAATTATATTTCAGTAAGAAGCCTTTAAAAATTGATGAATCAGCTATTCCAAAAGTAGAATATAGTAATATTCAGCTTTTAAATTTTT
AAAATTTTATTTTCTGATAGTTGTTACTGCTGTCATTAAAACCAGAAGTGTTAGACACTAACAGGCAGGTGCACAAGAACTTTTCTGTAT
GACTTCCAAAAGACAAGCTGACTAATTCATGCAGGCAGCATATTTGACATTAATAAATGGCCAAGCCATTCCTATTTCCAAGGGGTTGGC
TTCTTTCAAGCAGTTCTTACACTGAGACCTTTCTTCAGAGAGCTTTTCTAGGATAACAAATAGGGTTGGATCAAAACCTTTCAGGGACAC
AGAGAGACAGAGAGAGAGAGACTAACAGTTTCTACTCTGTTGAAAGATTTCTTCCTCCTTGTTTCTTTTCATTTTCTCTCAATAATTTTT
TTTTCTTCACCCTGCCTTGGGAACATTTTCTGCTTTTAAAAAACTGTACCTTGAGCTTGATCATTTTTATGGCATTTTTTTTTTTTAAGG
GCATATATAGAGTTCATTCTTGGGATGGAAAGCTGAA

>6845_6845_1_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000360025_PRCP_chr11_82549616_ENST00000313010_length(amino acids)=168AA_BP=34
MARAPPAGWGFSSLGADAADLPATVADHGRQRDPACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISS
HTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_2_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000360025_PRCP_chr11_82549616_ENST00000393399_length(transcript)=1061nt_BP=118nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCGATGACATGTTTGAACCTCA
CTCATGGAACTTAAAGGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGATCACTACTATGTATGGAGG
CAAAAACATTAGTTCACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAGTAACTAAGGATATCACAGA
CACTCTGGTTGCAGTCACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATCCTATGTCTGTGCTGTTAGC
CCGCTCCTTGGAAGTTAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACTGAGAAACTTTTGATTGTTT
TCAATTTCTTCTTTTATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCTTTTGTTTATCATTAGATTT
GATGGGGCCAAAGTTGAGATAGAATAGAGGGTGATGACGGTAAGAGCAAGTGTCCCATGAATGTGATTTCCTGGGTTCTCACTGTCTTTG
CACCACGTCTAGGAAGAATCTTCTTGATAGCTCTCCCACACCATCAGTGGCCCTCATAACTGGAGTAGAGTTCCTGGTTGCTTTTCATAA
GAGGGAGAGTTACTTTCTTTGTATCTCTGCAAGCAGAGATTTCTCTTTGGTTTTGAGGTTGAAGTGTCTTTGGCCCATTTGTAAGTCCCC
ATCCCTACCCTACACAAAGTAAAAGCAGAAGATAGATAAAAAATGATGTAATTGCAGCTGGTAGGATGTCTGGTGCCAATCCAGGAAGTG
AGAGCCATTTCTTTTGTACCGGATTTAATGACTTTGAACTGTGCTGTAAATAAATAATACAGCTGGACCTT

>6845_6845_2_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000360025_PRCP_chr11_82549616_ENST00000393399_length(amino acids)=168AA_BP=34
MARAPPAGWGFSSLGADAADLPATVADHGRQRDPACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISS
HTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_3_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000360025_PRCP_chr11_82549616_ENST00000535099_length(transcript)=639nt_BP=118nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCGATGACATGTTTGAACCTCA
CTCATGGAACTTAAAGGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGATCACTACTATGTATGGAGG
CAAAAACATTAGTTCACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAGTAACTAAGGATATCACAGA
CACTCTGGTTGCAGTCACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATCCTATGTCTGTGCTGTTAGC
CCGCTCCTTGGAAGTTAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACTGAGAAACTTTTGATTGTTT
TCAATTTCTTCTTTTATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCTTTTGTTTATCATTAGATTT
GATGGGGCC

>6845_6845_3_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000360025_PRCP_chr11_82549616_ENST00000535099_length(amino acids)=168AA_BP=34
MARAPPAGWGFSSLGADAADLPATVADHGRQRDPACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISS
HTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_4_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000360025_PRCP_chr11_82550467_ENST00000313010_length(transcript)=2092nt_BP=118nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGGTAGTGTGCCAGTATTTGAAAAATCCCAATGTATCTGATTCACTGCTGCTGCAGAATATTTT
CCAAGCTCTGAATGTATATTACAATTATTCGGGCCAGGTGAAATGCCTGAATATTTCAGAGACAGCAACTAGCAGTCTGGGAACACTGGG
TTGGAGCTATCAGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCGATGACATGTTTGAACCTCACTCATGGAACTTAAA
GGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGATCACTACTATGTATGGAGGCAAAAACATTAGTTC
ACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAGTAACTAAGGATATCACAGACACTCTGGTTGCAGT
CACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATCCTATGTCTGTGCTGTTAGCCCGCTCCTTGGAAGT
TAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACTGAGAAACTTTTGATTGTTTTCAATTTCTTCTTTT
ATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCTTTTGTTTATCATTAGATTTGATGGGGCCAAAGTT
GAGATAGAATAGAGGGTGATGACGGTAAGAGCAAGTGTCCCATGAATGTGATTTCCTGGGTTCTCACTGTCTTTGCACCACGTCTAGGAA
GAATCTTCTTGATAGCTCTCCCACACCATCAGTGGCCCTCATAACTGGAGTAGAGTTCCTGGTTGCTTTTCATAAGAGGGAGAGTTACTT
TCTTTGTATCTCTGCAAGCAGAGATTTCTCTTTGGTTTTGAGGTTGAAGTGTCTTTGGCCCATTTGTAAGTCCCCATCCCTACCCTACAC
AAAGTAAAAGCAGAAGATAGATAAAAAATGATGTAATTGCAGCTGGTAGGATGTCTGGTGCCAATCCAGGAAGTGAGAGCCATTTCTTTT
GTACCGGATTTAATGACTTTGAACTGTGCTGTAAATAAATAATACAGCTGGACCTTATACCTGTGTGTTGCTTCTGAAGCTCACTTCAAC
TCCGGCTGATGGAAATGCTGTGTGCACTGGGCTTAGCTGTTTTTGGAAAGTCCTTTAATTTTTTCTCTTCCACTTGGCAGCTTTTCTTAG
TTCTGGGATGTTGGCCACTGTGGTACTGCCAGTAAGAAATCTGGCCTTTTTCTGCTCCATTTCTCTTTGTTTCTAAGGTCAGTTTTAATT
TGTTTGAATTCTGCCAGTTTAGGAAAATGACTCTGTTTTGTCTTTTTAAATCTGAGCAAGCTTTATGCTGTAGTCACTAATTATATTTCA
GTAAGAAGCCTTTAAAAATTGATGAATCAGCTATTCCAAAAGTAGAATATAGTAATATTCAGCTTTTAAATTTTTAAAATTTTATTTTCT
GATAGTTGTTACTGCTGTCATTAAAACCAGAAGTGTTAGACACTAACAGGCAGGTGCACAAGAACTTTTCTGTATGACTTCCAAAAGACA
AGCTGACTAATTCATGCAGGCAGCATATTTGACATTAATAAATGGCCAAGCCATTCCTATTTCCAAGGGGTTGGCTTCTTTCAAGCAGTT
CTTACACTGAGACCTTTCTTCAGAGAGCTTTTCTAGGATAACAAATAGGGTTGGATCAAAACCTTTCAGGGACACAGAGAGACAGAGAGA
GAGAGACTAACAGTTTCTACTCTGTTGAAAGATTTCTTCCTCCTTGTTTCTTTTCATTTTCTCTCAATAATTTTTTTTTCTTCACCCTGC
CTTGGGAACATTTTCTGCTTTTAAAAAACTGTACCTTGAGCTTGATCATTTTTATGGCATTTTTTTTTTTTAAGGGCATATATAGAGTTC
ATTCTTGGGATGGAAAGCTGAA

>6845_6845_4_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000360025_PRCP_chr11_82550467_ENST00000313010_length(amino acids)=223AA_BP=34
MARAPPAGWGFSSLGADAADLPATVADHGRQRDPVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQA
CTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEG
AHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_5_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000360025_PRCP_chr11_82550467_ENST00000393399_length(transcript)=1226nt_BP=118nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGGTAGTGTGCCAGTATTTGAAAAATCCCAATGTATCTGATTCACTGCTGCTGCAGAATATTTT
CCAAGCTCTGAATGTATATTACAATTATTCGGGCCAGGTGAAATGCCTGAATATTTCAGAGACAGCAACTAGCAGTCTGGGAACACTGGG
TTGGAGCTATCAGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCGATGACATGTTTGAACCTCACTCATGGAACTTAAA
GGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGATCACTACTATGTATGGAGGCAAAAACATTAGTTC
ACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAGTAACTAAGGATATCACAGACACTCTGGTTGCAGT
CACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATCCTATGTCTGTGCTGTTAGCCCGCTCCTTGGAAGT
TAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACTGAGAAACTTTTGATTGTTTTCAATTTCTTCTTTT
ATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCTTTTGTTTATCATTAGATTTGATGGGGCCAAAGTT
GAGATAGAATAGAGGGTGATGACGGTAAGAGCAAGTGTCCCATGAATGTGATTTCCTGGGTTCTCACTGTCTTTGCACCACGTCTAGGAA
GAATCTTCTTGATAGCTCTCCCACACCATCAGTGGCCCTCATAACTGGAGTAGAGTTCCTGGTTGCTTTTCATAAGAGGGAGAGTTACTT
TCTTTGTATCTCTGCAAGCAGAGATTTCTCTTTGGTTTTGAGGTTGAAGTGTCTTTGGCCCATTTGTAAGTCCCCATCCCTACCCTACAC
AAAGTAAAAGCAGAAGATAGATAAAAAATGATGTAATTGCAGCTGGTAGGATGTCTGGTGCCAATCCAGGAAGTGAGAGCCATTTCTTTT
GTACCGGATTTAATGACTTTGAACTGTGCTGTAAATAAATAATACAGCTGGACCTT

>6845_6845_5_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000360025_PRCP_chr11_82550467_ENST00000393399_length(amino acids)=223AA_BP=34
MARAPPAGWGFSSLGADAADLPATVADHGRQRDPVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQA
CTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEG
AHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_6_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000360025_PRCP_chr11_82550467_ENST00000535099_length(transcript)=804nt_BP=118nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGGTAGTGTGCCAGTATTTGAAAAATCCCAATGTATCTGATTCACTGCTGCTGCAGAATATTTT
CCAAGCTCTGAATGTATATTACAATTATTCGGGCCAGGTGAAATGCCTGAATATTTCAGAGACAGCAACTAGCAGTCTGGGAACACTGGG
TTGGAGCTATCAGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCGATGACATGTTTGAACCTCACTCATGGAACTTAAA
GGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGATCACTACTATGTATGGAGGCAAAAACATTAGTTC
ACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAGTAACTAAGGATATCACAGACACTCTGGTTGCAGT
CACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATCCTATGTCTGTGCTGTTAGCCCGCTCCTTGGAAGT
TAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACTGAGAAACTTTTGATTGTTTTCAATTTCTTCTTTT
ATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCTTTTGTTTATCATTAGATTTGATGGGGCC

>6845_6845_6_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000360025_PRCP_chr11_82550467_ENST00000535099_length(amino acids)=223AA_BP=34
MARAPPAGWGFSSLGADAADLPATVADHGRQRDPVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQA
CTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEG
AHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_7_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000393505_PRCP_chr11_82549616_ENST00000313010_length(transcript)=2051nt_BP=242nt
ACCCCGCGCGGTTCCACGCCCCTGGCCGCGGCCCGGGCGCTGCGCTGCTCGACGCGGCGGGCGGCGGGCGGGGACCGGGGGCGGGGGCGG
CGGCGGCGGCCGGGAGAGCGGAGGAGGCGGAGCAGGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCC
TGGGCGCTGACGCCGCGGACCTCCCTGCGACCGTCGCGGACCATGGGCGACAAAGGGACCCGGCCTGCACAGAAGTAGTCATGCCCTTTT
GTACTAATGGTGTCGATGACATGTTTGAACCTCACTCATGGAACTTAAAGGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGAC
CAAGGCCCTCCTGGATCACTACTATGTATGGAGGCAAAAACATTAGTTCACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCT
GGTCAGGAGGTGGAGTAACTAAGGATATCACAGACACTCTGGTTGCAGTCACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCA
AGAATGCCTTGGATCCTATGTCTGTGCTGTTAGCCCGCTCCTTGGAAGTTAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTG
CGGGAAAGCAGCACTGAGAAACTTTTGATTGTTTTCAATTTCTTCTTTTATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTAC
ATGTAATTACCTTCTTTTGTTTATCATTAGATTTGATGGGGCCAAAGTTGAGATAGAATAGAGGGTGATGACGGTAAGAGCAAGTGTCCC
ATGAATGTGATTTCCTGGGTTCTCACTGTCTTTGCACCACGTCTAGGAAGAATCTTCTTGATAGCTCTCCCACACCATCAGTGGCCCTCA
TAACTGGAGTAGAGTTCCTGGTTGCTTTTCATAAGAGGGAGAGTTACTTTCTTTGTATCTCTGCAAGCAGAGATTTCTCTTTGGTTTTGA
GGTTGAAGTGTCTTTGGCCCATTTGTAAGTCCCCATCCCTACCCTACACAAAGTAAAAGCAGAAGATAGATAAAAAATGATGTAATTGCA
GCTGGTAGGATGTCTGGTGCCAATCCAGGAAGTGAGAGCCATTTCTTTTGTACCGGATTTAATGACTTTGAACTGTGCTGTAAATAAATA
ATACAGCTGGACCTTATACCTGTGTGTTGCTTCTGAAGCTCACTTCAACTCCGGCTGATGGAAATGCTGTGTGCACTGGGCTTAGCTGTT
TTTGGAAAGTCCTTTAATTTTTTCTCTTCCACTTGGCAGCTTTTCTTAGTTCTGGGATGTTGGCCACTGTGGTACTGCCAGTAAGAAATC
TGGCCTTTTTCTGCTCCATTTCTCTTTGTTTCTAAGGTCAGTTTTAATTTGTTTGAATTCTGCCAGTTTAGGAAAATGACTCTGTTTTGT
CTTTTTAAATCTGAGCAAGCTTTATGCTGTAGTCACTAATTATATTTCAGTAAGAAGCCTTTAAAAATTGATGAATCAGCTATTCCAAAA
GTAGAATATAGTAATATTCAGCTTTTAAATTTTTAAAATTTTATTTTCTGATAGTTGTTACTGCTGTCATTAAAACCAGAAGTGTTAGAC
ACTAACAGGCAGGTGCACAAGAACTTTTCTGTATGACTTCCAAAAGACAAGCTGACTAATTCATGCAGGCAGCATATTTGACATTAATAA
ATGGCCAAGCCATTCCTATTTCCAAGGGGTTGGCTTCTTTCAAGCAGTTCTTACACTGAGACCTTTCTTCAGAGAGCTTTTCTAGGATAA
CAAATAGGGTTGGATCAAAACCTTTCAGGGACACAGAGAGACAGAGAGAGAGAGACTAACAGTTTCTACTCTGTTGAAAGATTTCTTCCT
CCTTGTTTCTTTTCATTTTCTCTCAATAATTTTTTTTTCTTCACCCTGCCTTGGGAACATTTTCTGCTTTTAAAAAACTGTACCTTGAGC
TTGATCATTTTTATGGCATTTTTTTTTTTTAAGGGCATATATAGAGTTCATTCTTGGGATGGAAAGCTGAA

>6845_6845_7_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000393505_PRCP_chr11_82549616_ENST00000313010_length(amino acids)=200AA_BP=66
MLDAAGGGRGPGAGAAAAAGRAEEAEQGAGSGLARAPPAGWGFSSLGADAADLPATVADHGRQRDPACTEVVMPFCTNGVDDMFEPHSWN
LKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSL
EVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_8_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000393505_PRCP_chr11_82549616_ENST00000393399_length(transcript)=1185nt_BP=242nt
ACCCCGCGCGGTTCCACGCCCCTGGCCGCGGCCCGGGCGCTGCGCTGCTCGACGCGGCGGGCGGCGGGCGGGGACCGGGGGCGGGGGCGG
CGGCGGCGGCCGGGAGAGCGGAGGAGGCGGAGCAGGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCC
TGGGCGCTGACGCCGCGGACCTCCCTGCGACCGTCGCGGACCATGGGCGACAAAGGGACCCGGCCTGCACAGAAGTAGTCATGCCCTTTT
GTACTAATGGTGTCGATGACATGTTTGAACCTCACTCATGGAACTTAAAGGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGAC
CAAGGCCCTCCTGGATCACTACTATGTATGGAGGCAAAAACATTAGTTCACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCT
GGTCAGGAGGTGGAGTAACTAAGGATATCACAGACACTCTGGTTGCAGTCACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCA
AGAATGCCTTGGATCCTATGTCTGTGCTGTTAGCCCGCTCCTTGGAAGTTAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTG
CGGGAAAGCAGCACTGAGAAACTTTTGATTGTTTTCAATTTCTTCTTTTATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTAC
ATGTAATTACCTTCTTTTGTTTATCATTAGATTTGATGGGGCCAAAGTTGAGATAGAATAGAGGGTGATGACGGTAAGAGCAAGTGTCCC
ATGAATGTGATTTCCTGGGTTCTCACTGTCTTTGCACCACGTCTAGGAAGAATCTTCTTGATAGCTCTCCCACACCATCAGTGGCCCTCA
TAACTGGAGTAGAGTTCCTGGTTGCTTTTCATAAGAGGGAGAGTTACTTTCTTTGTATCTCTGCAAGCAGAGATTTCTCTTTGGTTTTGA
GGTTGAAGTGTCTTTGGCCCATTTGTAAGTCCCCATCCCTACCCTACACAAAGTAAAAGCAGAAGATAGATAAAAAATGATGTAATTGCA
GCTGGTAGGATGTCTGGTGCCAATCCAGGAAGTGAGAGCCATTTCTTTTGTACCGGATTTAATGACTTTGAACTGTGCTGTAAATAAATA
ATACAGCTGGACCTT

>6845_6845_8_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000393505_PRCP_chr11_82549616_ENST00000393399_length(amino acids)=200AA_BP=66
MLDAAGGGRGPGAGAAAAAGRAEEAEQGAGSGLARAPPAGWGFSSLGADAADLPATVADHGRQRDPACTEVVMPFCTNGVDDMFEPHSWN
LKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSL
EVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_9_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000393505_PRCP_chr11_82549616_ENST00000535099_length(transcript)=763nt_BP=242nt
ACCCCGCGCGGTTCCACGCCCCTGGCCGCGGCCCGGGCGCTGCGCTGCTCGACGCGGCGGGCGGCGGGCGGGGACCGGGGGCGGGGGCGG
CGGCGGCGGCCGGGAGAGCGGAGGAGGCGGAGCAGGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCC
TGGGCGCTGACGCCGCGGACCTCCCTGCGACCGTCGCGGACCATGGGCGACAAAGGGACCCGGCCTGCACAGAAGTAGTCATGCCCTTTT
GTACTAATGGTGTCGATGACATGTTTGAACCTCACTCATGGAACTTAAAGGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGAC
CAAGGCCCTCCTGGATCACTACTATGTATGGAGGCAAAAACATTAGTTCACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCT
GGTCAGGAGGTGGAGTAACTAAGGATATCACAGACACTCTGGTTGCAGTCACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCA
AGAATGCCTTGGATCCTATGTCTGTGCTGTTAGCCCGCTCCTTGGAAGTTAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTG
CGGGAAAGCAGCACTGAGAAACTTTTGATTGTTTTCAATTTCTTCTTTTATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTAC
ATGTAATTACCTTCTTTTGTTTATCATTAGATTTGATGGGGCC

>6845_6845_9_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000393505_PRCP_chr11_82549616_ENST00000535099_length(amino acids)=200AA_BP=66
MLDAAGGGRGPGAGAAAAAGRAEEAEQGAGSGLARAPPAGWGFSSLGADAADLPATVADHGRQRDPACTEVVMPFCTNGVDDMFEPHSWN
LKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSL
EVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_10_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000393505_PRCP_chr11_82550467_ENST00000313010_length(transcript)=2216nt_BP=242nt
ACCCCGCGCGGTTCCACGCCCCTGGCCGCGGCCCGGGCGCTGCGCTGCTCGACGCGGCGGGCGGCGGGCGGGGACCGGGGGCGGGGGCGG
CGGCGGCGGCCGGGAGAGCGGAGGAGGCGGAGCAGGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCC
TGGGCGCTGACGCCGCGGACCTCCCTGCGACCGTCGCGGACCATGGGCGACAAAGGGACCCGGTAGTGTGCCAGTATTTGAAAAATCCCA
ATGTATCTGATTCACTGCTGCTGCAGAATATTTTCCAAGCTCTGAATGTATATTACAATTATTCGGGCCAGGTGAAATGCCTGAATATTT
CAGAGACAGCAACTAGCAGTCTGGGAACACTGGGTTGGAGCTATCAGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCG
ATGACATGTTTGAACCTCACTCATGGAACTTAAAGGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGA
TCACTACTATGTATGGAGGCAAAAACATTAGTTCACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAG
TAACTAAGGATATCACAGACACTCTGGTTGCAGTCACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATC
CTATGTCTGTGCTGTTAGCCCGCTCCTTGGAAGTTAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACT
GAGAAACTTTTGATTGTTTTCAATTTCTTCTTTTATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCT
TTTGTTTATCATTAGATTTGATGGGGCCAAAGTTGAGATAGAATAGAGGGTGATGACGGTAAGAGCAAGTGTCCCATGAATGTGATTTCC
TGGGTTCTCACTGTCTTTGCACCACGTCTAGGAAGAATCTTCTTGATAGCTCTCCCACACCATCAGTGGCCCTCATAACTGGAGTAGAGT
TCCTGGTTGCTTTTCATAAGAGGGAGAGTTACTTTCTTTGTATCTCTGCAAGCAGAGATTTCTCTTTGGTTTTGAGGTTGAAGTGTCTTT
GGCCCATTTGTAAGTCCCCATCCCTACCCTACACAAAGTAAAAGCAGAAGATAGATAAAAAATGATGTAATTGCAGCTGGTAGGATGTCT
GGTGCCAATCCAGGAAGTGAGAGCCATTTCTTTTGTACCGGATTTAATGACTTTGAACTGTGCTGTAAATAAATAATACAGCTGGACCTT
ATACCTGTGTGTTGCTTCTGAAGCTCACTTCAACTCCGGCTGATGGAAATGCTGTGTGCACTGGGCTTAGCTGTTTTTGGAAAGTCCTTT
AATTTTTTCTCTTCCACTTGGCAGCTTTTCTTAGTTCTGGGATGTTGGCCACTGTGGTACTGCCAGTAAGAAATCTGGCCTTTTTCTGCT
CCATTTCTCTTTGTTTCTAAGGTCAGTTTTAATTTGTTTGAATTCTGCCAGTTTAGGAAAATGACTCTGTTTTGTCTTTTTAAATCTGAG
CAAGCTTTATGCTGTAGTCACTAATTATATTTCAGTAAGAAGCCTTTAAAAATTGATGAATCAGCTATTCCAAAAGTAGAATATAGTAAT
ATTCAGCTTTTAAATTTTTAAAATTTTATTTTCTGATAGTTGTTACTGCTGTCATTAAAACCAGAAGTGTTAGACACTAACAGGCAGGTG
CACAAGAACTTTTCTGTATGACTTCCAAAAGACAAGCTGACTAATTCATGCAGGCAGCATATTTGACATTAATAAATGGCCAAGCCATTC
CTATTTCCAAGGGGTTGGCTTCTTTCAAGCAGTTCTTACACTGAGACCTTTCTTCAGAGAGCTTTTCTAGGATAACAAATAGGGTTGGAT
CAAAACCTTTCAGGGACACAGAGAGACAGAGAGAGAGAGACTAACAGTTTCTACTCTGTTGAAAGATTTCTTCCTCCTTGTTTCTTTTCA
TTTTCTCTCAATAATTTTTTTTTCTTCACCCTGCCTTGGGAACATTTTCTGCTTTTAAAAAACTGTACCTTGAGCTTGATCATTTTTATG
GCATTTTTTTTTTTTAAGGGCATATATAGAGTTCATTCTTGGGATGGAAAGCTGAA

>6845_6845_10_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000393505_PRCP_chr11_82550467_ENST00000313010_length(amino acids)=255AA_BP=66
MLDAAGGGRGPGAGAAAAAGRAEEAEQGAGSGLARAPPAGWGFSSLGADAADLPATVADHGRQRDPVVCQYLKNPNVSDSLLLQNIFQAL
NVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTN
IVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_11_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000393505_PRCP_chr11_82550467_ENST00000393399_length(transcript)=1350nt_BP=242nt
ACCCCGCGCGGTTCCACGCCCCTGGCCGCGGCCCGGGCGCTGCGCTGCTCGACGCGGCGGGCGGCGGGCGGGGACCGGGGGCGGGGGCGG
CGGCGGCGGCCGGGAGAGCGGAGGAGGCGGAGCAGGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCC
TGGGCGCTGACGCCGCGGACCTCCCTGCGACCGTCGCGGACCATGGGCGACAAAGGGACCCGGTAGTGTGCCAGTATTTGAAAAATCCCA
ATGTATCTGATTCACTGCTGCTGCAGAATATTTTCCAAGCTCTGAATGTATATTACAATTATTCGGGCCAGGTGAAATGCCTGAATATTT
CAGAGACAGCAACTAGCAGTCTGGGAACACTGGGTTGGAGCTATCAGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCG
ATGACATGTTTGAACCTCACTCATGGAACTTAAAGGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGA
TCACTACTATGTATGGAGGCAAAAACATTAGTTCACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAG
TAACTAAGGATATCACAGACACTCTGGTTGCAGTCACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATC
CTATGTCTGTGCTGTTAGCCCGCTCCTTGGAAGTTAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACT
GAGAAACTTTTGATTGTTTTCAATTTCTTCTTTTATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCT
TTTGTTTATCATTAGATTTGATGGGGCCAAAGTTGAGATAGAATAGAGGGTGATGACGGTAAGAGCAAGTGTCCCATGAATGTGATTTCC
TGGGTTCTCACTGTCTTTGCACCACGTCTAGGAAGAATCTTCTTGATAGCTCTCCCACACCATCAGTGGCCCTCATAACTGGAGTAGAGT
TCCTGGTTGCTTTTCATAAGAGGGAGAGTTACTTTCTTTGTATCTCTGCAAGCAGAGATTTCTCTTTGGTTTTGAGGTTGAAGTGTCTTT
GGCCCATTTGTAAGTCCCCATCCCTACCCTACACAAAGTAAAAGCAGAAGATAGATAAAAAATGATGTAATTGCAGCTGGTAGGATGTCT
GGTGCCAATCCAGGAAGTGAGAGCCATTTCTTTTGTACCGGATTTAATGACTTTGAACTGTGCTGTAAATAAATAATACAGCTGGACCTT

>6845_6845_11_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000393505_PRCP_chr11_82550467_ENST00000393399_length(amino acids)=255AA_BP=66
MLDAAGGGRGPGAGAAAAAGRAEEAEQGAGSGLARAPPAGWGFSSLGADAADLPATVADHGRQRDPVVCQYLKNPNVSDSLLLQNIFQAL
NVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTN
IVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_12_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000393505_PRCP_chr11_82550467_ENST00000535099_length(transcript)=928nt_BP=242nt
ACCCCGCGCGGTTCCACGCCCCTGGCCGCGGCCCGGGCGCTGCGCTGCTCGACGCGGCGGGCGGCGGGCGGGGACCGGGGGCGGGGGCGG
CGGCGGCGGCCGGGAGAGCGGAGGAGGCGGAGCAGGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCC
TGGGCGCTGACGCCGCGGACCTCCCTGCGACCGTCGCGGACCATGGGCGACAAAGGGACCCGGTAGTGTGCCAGTATTTGAAAAATCCCA
ATGTATCTGATTCACTGCTGCTGCAGAATATTTTCCAAGCTCTGAATGTATATTACAATTATTCGGGCCAGGTGAAATGCCTGAATATTT
CAGAGACAGCAACTAGCAGTCTGGGAACACTGGGTTGGAGCTATCAGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCG
ATGACATGTTTGAACCTCACTCATGGAACTTAAAGGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGA
TCACTACTATGTATGGAGGCAAAAACATTAGTTCACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAG
TAACTAAGGATATCACAGACACTCTGGTTGCAGTCACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATC
CTATGTCTGTGCTGTTAGCCCGCTCCTTGGAAGTTAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACT
GAGAAACTTTTGATTGTTTTCAATTTCTTCTTTTATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCT
TTTGTTTATCATTAGATTTGATGGGGCC

>6845_6845_12_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000393505_PRCP_chr11_82550467_ENST00000535099_length(amino acids)=255AA_BP=66
MLDAAGGGRGPGAGAAAAAGRAEEAEQGAGSGLARAPPAGWGFSSLGADAADLPATVADHGRQRDPVVCQYLKNPNVSDSLLLQNIFQAL
NVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTN
IVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_13_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000420843_PRCP_chr11_82549616_ENST00000313010_length(transcript)=1927nt_BP=118nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCGATGACATGTTTGAACCTCA
CTCATGGAACTTAAAGGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGATCACTACTATGTATGGAGG
CAAAAACATTAGTTCACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAGTAACTAAGGATATCACAGA
CACTCTGGTTGCAGTCACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATCCTATGTCTGTGCTGTTAGC
CCGCTCCTTGGAAGTTAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACTGAGAAACTTTTGATTGTTT
TCAATTTCTTCTTTTATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCTTTTGTTTATCATTAGATTT
GATGGGGCCAAAGTTGAGATAGAATAGAGGGTGATGACGGTAAGAGCAAGTGTCCCATGAATGTGATTTCCTGGGTTCTCACTGTCTTTG
CACCACGTCTAGGAAGAATCTTCTTGATAGCTCTCCCACACCATCAGTGGCCCTCATAACTGGAGTAGAGTTCCTGGTTGCTTTTCATAA
GAGGGAGAGTTACTTTCTTTGTATCTCTGCAAGCAGAGATTTCTCTTTGGTTTTGAGGTTGAAGTGTCTTTGGCCCATTTGTAAGTCCCC
ATCCCTACCCTACACAAAGTAAAAGCAGAAGATAGATAAAAAATGATGTAATTGCAGCTGGTAGGATGTCTGGTGCCAATCCAGGAAGTG
AGAGCCATTTCTTTTGTACCGGATTTAATGACTTTGAACTGTGCTGTAAATAAATAATACAGCTGGACCTTATACCTGTGTGTTGCTTCT
GAAGCTCACTTCAACTCCGGCTGATGGAAATGCTGTGTGCACTGGGCTTAGCTGTTTTTGGAAAGTCCTTTAATTTTTTCTCTTCCACTT
GGCAGCTTTTCTTAGTTCTGGGATGTTGGCCACTGTGGTACTGCCAGTAAGAAATCTGGCCTTTTTCTGCTCCATTTCTCTTTGTTTCTA
AGGTCAGTTTTAATTTGTTTGAATTCTGCCAGTTTAGGAAAATGACTCTGTTTTGTCTTTTTAAATCTGAGCAAGCTTTATGCTGTAGTC
ACTAATTATATTTCAGTAAGAAGCCTTTAAAAATTGATGAATCAGCTATTCCAAAAGTAGAATATAGTAATATTCAGCTTTTAAATTTTT
AAAATTTTATTTTCTGATAGTTGTTACTGCTGTCATTAAAACCAGAAGTGTTAGACACTAACAGGCAGGTGCACAAGAACTTTTCTGTAT
GACTTCCAAAAGACAAGCTGACTAATTCATGCAGGCAGCATATTTGACATTAATAAATGGCCAAGCCATTCCTATTTCCAAGGGGTTGGC
TTCTTTCAAGCAGTTCTTACACTGAGACCTTTCTTCAGAGAGCTTTTCTAGGATAACAAATAGGGTTGGATCAAAACCTTTCAGGGACAC
AGAGAGACAGAGAGAGAGAGACTAACAGTTTCTACTCTGTTGAAAGATTTCTTCCTCCTTGTTTCTTTTCATTTTCTCTCAATAATTTTT
TTTTCTTCACCCTGCCTTGGGAACATTTTCTGCTTTTAAAAAACTGTACCTTGAGCTTGATCATTTTTATGGCATTTTTTTTTTTTAAGG
GCATATATAGAGTTCATTCTTGGGATGGAAAGCTGAA

>6845_6845_13_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000420843_PRCP_chr11_82549616_ENST00000313010_length(amino acids)=168AA_BP=34
MARAPPAGWGFSSLGADAADLPATVADHGRQRDPACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISS
HTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_14_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000420843_PRCP_chr11_82549616_ENST00000393399_length(transcript)=1061nt_BP=118nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCGATGACATGTTTGAACCTCA
CTCATGGAACTTAAAGGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGATCACTACTATGTATGGAGG
CAAAAACATTAGTTCACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAGTAACTAAGGATATCACAGA
CACTCTGGTTGCAGTCACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATCCTATGTCTGTGCTGTTAGC
CCGCTCCTTGGAAGTTAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACTGAGAAACTTTTGATTGTTT
TCAATTTCTTCTTTTATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCTTTTGTTTATCATTAGATTT
GATGGGGCCAAAGTTGAGATAGAATAGAGGGTGATGACGGTAAGAGCAAGTGTCCCATGAATGTGATTTCCTGGGTTCTCACTGTCTTTG
CACCACGTCTAGGAAGAATCTTCTTGATAGCTCTCCCACACCATCAGTGGCCCTCATAACTGGAGTAGAGTTCCTGGTTGCTTTTCATAA
GAGGGAGAGTTACTTTCTTTGTATCTCTGCAAGCAGAGATTTCTCTTTGGTTTTGAGGTTGAAGTGTCTTTGGCCCATTTGTAAGTCCCC
ATCCCTACCCTACACAAAGTAAAAGCAGAAGATAGATAAAAAATGATGTAATTGCAGCTGGTAGGATGTCTGGTGCCAATCCAGGAAGTG
AGAGCCATTTCTTTTGTACCGGATTTAATGACTTTGAACTGTGCTGTAAATAAATAATACAGCTGGACCTT

>6845_6845_14_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000420843_PRCP_chr11_82549616_ENST00000393399_length(amino acids)=168AA_BP=34
MARAPPAGWGFSSLGADAADLPATVADHGRQRDPACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISS
HTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_15_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000420843_PRCP_chr11_82549616_ENST00000535099_length(transcript)=639nt_BP=118nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCGATGACATGTTTGAACCTCA
CTCATGGAACTTAAAGGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGATCACTACTATGTATGGAGG
CAAAAACATTAGTTCACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAGTAACTAAGGATATCACAGA
CACTCTGGTTGCAGTCACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATCCTATGTCTGTGCTGTTAGC
CCGCTCCTTGGAAGTTAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACTGAGAAACTTTTGATTGTTT
TCAATTTCTTCTTTTATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCTTTTGTTTATCATTAGATTT
GATGGGGCC

>6845_6845_15_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000420843_PRCP_chr11_82549616_ENST00000535099_length(amino acids)=168AA_BP=34
MARAPPAGWGFSSLGADAADLPATVADHGRQRDPACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISS
HTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_16_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000420843_PRCP_chr11_82550467_ENST00000313010_length(transcript)=2092nt_BP=118nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGGTAGTGTGCCAGTATTTGAAAAATCCCAATGTATCTGATTCACTGCTGCTGCAGAATATTTT
CCAAGCTCTGAATGTATATTACAATTATTCGGGCCAGGTGAAATGCCTGAATATTTCAGAGACAGCAACTAGCAGTCTGGGAACACTGGG
TTGGAGCTATCAGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCGATGACATGTTTGAACCTCACTCATGGAACTTAAA
GGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGATCACTACTATGTATGGAGGCAAAAACATTAGTTC
ACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAGTAACTAAGGATATCACAGACACTCTGGTTGCAGT
CACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATCCTATGTCTGTGCTGTTAGCCCGCTCCTTGGAAGT
TAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACTGAGAAACTTTTGATTGTTTTCAATTTCTTCTTTT
ATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCTTTTGTTTATCATTAGATTTGATGGGGCCAAAGTT
GAGATAGAATAGAGGGTGATGACGGTAAGAGCAAGTGTCCCATGAATGTGATTTCCTGGGTTCTCACTGTCTTTGCACCACGTCTAGGAA
GAATCTTCTTGATAGCTCTCCCACACCATCAGTGGCCCTCATAACTGGAGTAGAGTTCCTGGTTGCTTTTCATAAGAGGGAGAGTTACTT
TCTTTGTATCTCTGCAAGCAGAGATTTCTCTTTGGTTTTGAGGTTGAAGTGTCTTTGGCCCATTTGTAAGTCCCCATCCCTACCCTACAC
AAAGTAAAAGCAGAAGATAGATAAAAAATGATGTAATTGCAGCTGGTAGGATGTCTGGTGCCAATCCAGGAAGTGAGAGCCATTTCTTTT
GTACCGGATTTAATGACTTTGAACTGTGCTGTAAATAAATAATACAGCTGGACCTTATACCTGTGTGTTGCTTCTGAAGCTCACTTCAAC
TCCGGCTGATGGAAATGCTGTGTGCACTGGGCTTAGCTGTTTTTGGAAAGTCCTTTAATTTTTTCTCTTCCACTTGGCAGCTTTTCTTAG
TTCTGGGATGTTGGCCACTGTGGTACTGCCAGTAAGAAATCTGGCCTTTTTCTGCTCCATTTCTCTTTGTTTCTAAGGTCAGTTTTAATT
TGTTTGAATTCTGCCAGTTTAGGAAAATGACTCTGTTTTGTCTTTTTAAATCTGAGCAAGCTTTATGCTGTAGTCACTAATTATATTTCA
GTAAGAAGCCTTTAAAAATTGATGAATCAGCTATTCCAAAAGTAGAATATAGTAATATTCAGCTTTTAAATTTTTAAAATTTTATTTTCT
GATAGTTGTTACTGCTGTCATTAAAACCAGAAGTGTTAGACACTAACAGGCAGGTGCACAAGAACTTTTCTGTATGACTTCCAAAAGACA
AGCTGACTAATTCATGCAGGCAGCATATTTGACATTAATAAATGGCCAAGCCATTCCTATTTCCAAGGGGTTGGCTTCTTTCAAGCAGTT
CTTACACTGAGACCTTTCTTCAGAGAGCTTTTCTAGGATAACAAATAGGGTTGGATCAAAACCTTTCAGGGACACAGAGAGACAGAGAGA
GAGAGACTAACAGTTTCTACTCTGTTGAAAGATTTCTTCCTCCTTGTTTCTTTTCATTTTCTCTCAATAATTTTTTTTTCTTCACCCTGC
CTTGGGAACATTTTCTGCTTTTAAAAAACTGTACCTTGAGCTTGATCATTTTTATGGCATTTTTTTTTTTTAAGGGCATATATAGAGTTC
ATTCTTGGGATGGAAAGCTGAA

>6845_6845_16_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000420843_PRCP_chr11_82550467_ENST00000313010_length(amino acids)=223AA_BP=34
MARAPPAGWGFSSLGADAADLPATVADHGRQRDPVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQA
CTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEG
AHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_17_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000420843_PRCP_chr11_82550467_ENST00000393399_length(transcript)=1226nt_BP=118nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGGTAGTGTGCCAGTATTTGAAAAATCCCAATGTATCTGATTCACTGCTGCTGCAGAATATTTT
CCAAGCTCTGAATGTATATTACAATTATTCGGGCCAGGTGAAATGCCTGAATATTTCAGAGACAGCAACTAGCAGTCTGGGAACACTGGG
TTGGAGCTATCAGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCGATGACATGTTTGAACCTCACTCATGGAACTTAAA
GGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGATCACTACTATGTATGGAGGCAAAAACATTAGTTC
ACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAGTAACTAAGGATATCACAGACACTCTGGTTGCAGT
CACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATCCTATGTCTGTGCTGTTAGCCCGCTCCTTGGAAGT
TAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACTGAGAAACTTTTGATTGTTTTCAATTTCTTCTTTT
ATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCTTTTGTTTATCATTAGATTTGATGGGGCCAAAGTT
GAGATAGAATAGAGGGTGATGACGGTAAGAGCAAGTGTCCCATGAATGTGATTTCCTGGGTTCTCACTGTCTTTGCACCACGTCTAGGAA
GAATCTTCTTGATAGCTCTCCCACACCATCAGTGGCCCTCATAACTGGAGTAGAGTTCCTGGTTGCTTTTCATAAGAGGGAGAGTTACTT
TCTTTGTATCTCTGCAAGCAGAGATTTCTCTTTGGTTTTGAGGTTGAAGTGTCTTTGGCCCATTTGTAAGTCCCCATCCCTACCCTACAC
AAAGTAAAAGCAGAAGATAGATAAAAAATGATGTAATTGCAGCTGGTAGGATGTCTGGTGCCAATCCAGGAAGTGAGAGCCATTTCTTTT
GTACCGGATTTAATGACTTTGAACTGTGCTGTAAATAAATAATACAGCTGGACCTT

>6845_6845_17_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000420843_PRCP_chr11_82550467_ENST00000393399_length(amino acids)=223AA_BP=34
MARAPPAGWGFSSLGADAADLPATVADHGRQRDPVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQA
CTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEG
AHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------
>6845_6845_18_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000420843_PRCP_chr11_82550467_ENST00000535099_length(transcript)=804nt_BP=118nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGGTAGTGTGCCAGTATTTGAAAAATCCCAATGTATCTGATTCACTGCTGCTGCAGAATATTTT
CCAAGCTCTGAATGTATATTACAATTATTCGGGCCAGGTGAAATGCCTGAATATTTCAGAGACAGCAACTAGCAGTCTGGGAACACTGGG
TTGGAGCTATCAGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCGATGACATGTTTGAACCTCACTCATGGAACTTAAA
GGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGATCACTACTATGTATGGAGGCAAAAACATTAGTTC
ACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAGTAACTAAGGATATCACAGACACTCTGGTTGCAGT
CACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATCCTATGTCTGTGCTGTTAGCCCGCTCCTTGGAAGT
TAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACTGAGAAACTTTTGATTGTTTTCAATTTCTTCTTTT
ATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCTTTTGTTTATCATTAGATTTGATGGGGCC

>6845_6845_18_ARRB1-PRCP_ARRB1_chr11_75062632_ENST00000420843_PRCP_chr11_82550467_ENST00000535099_length(amino acids)=223AA_BP=34
MARAPPAGWGFSSLGADAADLPATVADHGRQRDPVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQA
CTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEG
AHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ARRB1-PRCP

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ARRB1	chr11:75062632	chr11:82549616	ENST00000360025	-	1	15	45_86	6.666666666666667	411.0	CHRM2
Hgene	ARRB1	chr11:75062632	chr11:82549616	ENST00000420843	-	1	16	45_86	6.666666666666667	419.0	CHRM2
Hgene	ARRB1	chr11:75062632	chr11:82550467	ENST00000360025	-	1	15	45_86	6.666666666666667	411.0	CHRM2
Hgene	ARRB1	chr11:75062632	chr11:82550467	ENST00000420843	-	1	16	45_86	6.666666666666667	419.0	CHRM2
Hgene	ARRB1	chr11:75062632	chr11:82549616	ENST00000360025	-	1	15	1_163	6.666666666666667	411.0	SRC
Hgene	ARRB1	chr11:75062632	chr11:82549616	ENST00000420843	-	1	16	1_163	6.666666666666667	419.0	SRC
Hgene	ARRB1	chr11:75062632	chr11:82550467	ENST00000360025	-	1	15	1_163	6.666666666666667	411.0	SRC
Hgene	ARRB1	chr11:75062632	chr11:82550467	ENST00000420843	-	1	16	1_163	6.666666666666667	419.0	SRC
Hgene	ARRB1	chr11:75062632	chr11:82549616	ENST00000360025	-	1	15	318_418	6.666666666666667	411.0	TRAF6
Hgene	ARRB1	chr11:75062632	chr11:82549616	ENST00000420843	-	1	16	318_418	6.666666666666667	419.0	TRAF6
Hgene	ARRB1	chr11:75062632	chr11:82550467	ENST00000360025	-	1	15	318_418	6.666666666666667	411.0	TRAF6
Hgene	ARRB1	chr11:75062632	chr11:82550467	ENST00000420843	-	1	16	318_418	6.666666666666667	419.0	TRAF6

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ARRB1-PRCP

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ARRB1-PRCP

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ARRB1	C0023890	Liver Cirrhosis	1	CTD_human
Hgene	ARRB1	C0041696	Unipolar Depression	1	PSYGENET
Hgene	ARRB1	C0239946	Fibrosis, Liver	1	CTD_human
Hgene	ARRB1	C1269683	Major Depressive Disorder	1	PSYGENET
Hgene	ARRB1	C3178803	Social Anhedonia	1	PSYGENET

Fusion Gene Studies in Kim Lab

Fusion gene:ARRB1-PRCP (FusionGDB2 ID:HG408TG5547)

Fusion Gene Summary for ARRB1-PRCP

Fusion Gene ORF analysis for ARRB1-PRCP

Fusion Genomic Features for ARRB1-PRCP

Fusion Protein Features for ARRB1-PRCP

Fusion Gene Sequence for ARRB1-PRCP

Fusion Gene PPI Analysis for ARRB1-PRCP

Related Drugs for ARRB1-PRCP

Related Diseases for ARRB1-PRCP

Fusion Gene Studies
in Kim Lab