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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAOA-ACTB (FusionGDB2 ID:HG4128TG60)

Fusion Gene Summary for MAOA-ACTB

check button Fusion gene summary
Fusion gene informationFusion gene name: MAOA-ACTB
Fusion gene ID: hg4128tg60
HgeneTgene
Gene symbol

MAOA

ACTB

Gene ID

4128

60

Gene namemonoamine oxidase Aactin beta
SynonymsBRNRS|MAO-ABRWS1|PS1TP5BP1
Cytomap('MAOA')('ACTB')

Xp11.3

7p22.1

Type of geneprotein-codingprotein-coding
Descriptionamine oxidase [flavin-containing] Amonoamine oxidase type Aactin, cytoplasmic 1I(2)-actinPS1TP5-binding protein 1beta cytoskeletal actin
Modification date2020032920200327
UniProtAcc

P21397

P60709

Ensembl transtripts involved in fusion geneENST00000338702, ENST00000542639, 
ENST00000497485, 
Fusion gene scores* DoF score3 X 3 X 2=1852 X 37 X 11=21164
# samples 358
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(58/21164*10)=-5.1894156123924
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAOA [Title/Abstract] AND ACTB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAOA(43601227)-ACTB(5568016), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACTB

GO:0098974

postsynaptic actin cytoskeleton organization

18341992



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for MAOA-ACTB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MAOA-ACTB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for MAOA-ACTB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:43601227/:5568016)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAOA

P21397

ACTB

P60709

FUNCTION: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.FUNCTION: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). {ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MAOA-ACTB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MAOA-ACTB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAOA-ACTB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMAOAP21397DB00780PhenelzineAntagonistSmall moleculeApproved
HgeneMAOAP21397DB00805MinaprineInhibitorSmall moleculeApproved
HgeneMAOAP21397DB01247IsocarboxazidInhibitorSmall moleculeApproved
HgeneMAOAP21397DB01626PargylineInhibitorSmall moleculeApproved
HgeneMAOAP21397DB03147Flavin adenine dinucleotideSmall moleculeApproved
HgeneMAOAP21397DB00191PhentermineAntagonistSmall moleculeApproved|Illicit
HgeneMAOAP21397DB01577MetamfetamineInhibitorSmall moleculeApproved|Illicit
HgeneMAOAP21397DB00752TranylcypromineInhibitorSmall moleculeApproved|Investigational
HgeneMAOAP21397DB00909ZonisamideInhibitorSmall moleculeApproved|Investigational
HgeneMAOAP21397DB01171MoclobemideAntagonist|InhibitorSmall moleculeApproved|Investigational
HgeneMAOAP21397DB14914Flortaucipir F-18BinderSmall moleculeApproved|Investigational
HgeneMAOAP21397DB01037SelegilineInhibitorSmall moleculeApproved|Investigational|Vet_approved
HgeneMAOAP21397DB04820NialamideSmall moleculeApproved|Withdrawn
HgeneMAOAP21397DB04821NomifensineSmall moleculeApproved|Withdrawn
HgeneMAOAP21397DB04832ZimelidineInhibitorSmall moleculeApproved|Withdrawn

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Related Diseases for MAOA-ACTB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAOAC0001973Alcoholic Intoxication, Chronic5PSYGENET
HgeneMAOAC0005586Bipolar Disorder5PSYGENET
HgeneMAOAC0011570Mental Depression5PSYGENET
HgeneMAOAC0011581Depressive disorder5PSYGENET
HgeneMAOAC0041696Unipolar Depression5PSYGENET
HgeneMAOAC0525045Mood Disorders5PSYGENET
HgeneMAOAC1269683Major Depressive Disorder5PSYGENET
HgeneMAOAC0796275Brunner Syndrome4CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneMAOAC0003431Antisocial Personality Disorder3CTD_human
HgeneMAOAC0004352Autistic Disorder3CTD_human
HgeneMAOAC0013409Dyssocial Behavior3CTD_human
HgeneMAOAC0019147Hepatic Coma3CTD_human
HgeneMAOAC0019151Hepatic Encephalopathy3CTD_human
HgeneMAOAC0751197Fulminant Hepatic Failure with Cerebral Edema3CTD_human
HgeneMAOAC0751198Hepatic Stupor3CTD_human
HgeneMAOAC0036341Schizophrenia2PSYGENET
HgeneMAOAC0085762Alcohol abuse2PSYGENET
HgeneMAOAC0270458Severe major depression with psychotic features2PSYGENET
HgeneMAOAC2362914clinical depression2PSYGENET
HgeneMAOAC0004930Behavior Disorders1CTD_human
HgeneMAOAC0004936Mental disorders1CTD_human
HgeneMAOAC0005587Depression, Bipolar1PSYGENET
HgeneMAOAC0009241Cognition Disorders1CTD_human
HgeneMAOAC0013415Dysthymic Disorder1PSYGENET
HgeneMAOAC0014175Endometriosis1CTD_human
HgeneMAOAC0020179Huntington Disease1CTD_human
HgeneMAOAC0020649Hypotension1CTD_human
HgeneMAOAC0026848Myopathy1CTD_human
HgeneMAOAC0030567Parkinson Disease1CTD_human
HgeneMAOAC0031511Pheochromocytoma1CTD_human
HgeneMAOAC0033054Prenatal Exposure Delayed Effects1CTD_human
HgeneMAOAC0033975Psychotic Disorders1PSYGENET
HgeneMAOAC0038644Sudden infant death syndrome1GENOMICS_ENGLAND
HgeneMAOAC0158850Fetal Malnutrition1CTD_human
HgeneMAOAC0269102Endometrioma1CTD_human
HgeneMAOAC0376338Diagnosis, Psychiatric1CTD_human
HgeneMAOAC0393574Huntington Disease, Late Onset1CTD_human
HgeneMAOAC0600427Cocaine Dependence1PSYGENET
HgeneMAOAC0745744End Stage Liver Disease1CTD_human
HgeneMAOAC0751207Akinetic-Rigid Variant of Huntington Disease1CTD_human
HgeneMAOAC0751208Juvenile Huntington Disease1CTD_human
HgeneMAOAC1136249Mental Retardation, X-Linked1CTD_human
HgeneMAOAC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
HgeneMAOAC1285261Fetal Nutrition Disorders1CTD_human
HgeneMAOAC2063866Depressive Disorder, Treatment-Resistant1PSYGENET
HgeneMAOAC2936476Chronic Liver Failure1CTD_human
HgeneMAOAC4046029Mental Disorders, Severe1CTD_human
TgeneC1855722Iris Coloboma with Ptosis, Hypertelorism, and Mental Retardation6CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC1846331Juvenile-onset dystonia2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC1853623Fryns-Aftimos Syndrome2GENOMICS_ENGLAND
TgeneC2239176Liver carcinoma2CTD_human
TgeneC0003129Anoxemia1CTD_human
TgeneC0003130Anoxia1CTD_human
TgeneC0005586Bipolar Disorder1PSYGENET
TgeneC0005818Blood Platelet Disorders1GENOMICS_ENGLAND
TgeneC0007097Carcinoma1CTD_human
TgeneC0009363Congenital ocular coloboma (disorder)1CTD_human
TgeneC0013393Dysostoses1CTD_human
TgeneC0013421Dystonia1CTD_human
TgeneC0014859Esophageal Neoplasms1CTD_human
TgeneC0018784Sensorineural Hearing Loss (disorder)1CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0024121Lung Neoplasms1CTD_human
TgeneC0024667Animal Mammary Neoplasms1CTD_human
TgeneC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneC0027626Neoplasm Invasiveness1CTD_human
TgeneC0029408Degenerative polyarthritis1CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0086743Osteoarthrosis Deformans1CTD_human
TgeneC0151744Myocardial Ischemia1CTD_human
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC0242184Hypoxia1CTD_human
TgeneC0242379Malignant neoplasm of lung1CTD_human
TgeneC0263579Pigmented hairy epidermal nevus1ORPHANET
TgeneC0265541Cranioschisis1CTD_human
TgeneC0272183Qualitative abnormality of granulocyte1GENOMICS_ENGLAND
TgeneC0376634Craniofacial Abnormalities1CTD_human
TgeneC0393588Dystonia, Paroxysmal1CTD_human
TgeneC0393610Dystonia, Diurnal1CTD_human
TgeneC0497552Congenital neurologic anomalies1CTD_human
TgeneC0546837Malignant neoplasm of esophagus1CTD_human
TgeneC0700292Hypoxemia1CTD_human
TgeneC0751093Dystonia, Limb1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1257925Mammary Carcinoma, Animal1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC1691779Sensory hearing loss1CTD_human
TgeneC1858042Becker Nevus Syndrome1ORPHANET
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneC4554007Uveoretinal Coloboma1CTD_human