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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Fusion gene:HCG18-MAP2K4 (FusionGDB2 ID:HG414777TG6416)

Fusion Gene Summary for HCG18-MAP2K4

check button Fusion gene summary
Fusion gene informationFusion gene name: HCG18-MAP2K4
Fusion gene ID: hg414777tg6416
HgeneTgene
Gene symbol

HCG18

MAP2K4

Gene ID

414777

6416

Gene nameHLA complex group 18mitogen-activated protein kinase kinase 4
Synonyms-JNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1
Cytomap('HCG18')('MAP2K4')

6p22.1

17p12

Type of genencRNAprotein-coding
DescriptionHLA complex group 18 (non-protein coding)dual specificity mitogen-activated protein kinase kinase 4JNK-activated kinase 1JNK-activating kinase 1MAP kinase kinase 4MAPK/ERK kinase 4MAPKK 4MEK 4SAPK/ERK kinase 1c-Jun N-terminal kinase kinase 1stress-activated protein kinase kinase 1
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000412685, ENST00000426882, 
ENST00000438412, ENST00000413358, 
ENST00000416289, ENST00000421520, 
ENST00000432895, ENST00000443079, 
ENST00000443909, ENST00000444126, 
ENST00000449544, ENST00000454129, 
ENST00000454269, ENST00000458584, 
ENST00000602290, ENST00000602319, 
ENST00000602498, ENST00000602516, 
ENST00000602550, ENST00000602591, 
ENST00000602698, ENST00000602861, 
ENST00000412685, ENST00000413358, 
ENST00000426882, ENST00000438412, 
ENST00000444126, ENST00000449544, 
ENST00000454129, ENST00000454269, 
ENST00000602290, ENST00000602550, 
ENST00000416289, ENST00000421520, 
ENST00000432895, ENST00000443079, 
ENST00000443909, ENST00000458584, 
ENST00000602319, ENST00000602498, 
ENST00000602516, ENST00000602591, 
ENST00000602698, ENST00000602861, 
Fusion gene scores* DoF score4 X 5 X 7=1408 X 10 X 6=480
# samples 910
** MAII scorelog2(9/140*10)=-0.637429920615292
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HCG18 [Title/Abstract] AND MAP2K4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHCG18(30294131)-MAP2K4(12011107), # samples:1
HCG18(30294130)-MAP2K4(12011106), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0221-02AHCG18chr6

30294131

-MAP2K4chr17

12011107

+
ChimerDB4GBMTCGA-06-0221HCG18chr6

30294130

-MAP2K4chr17

12011106

+


Top

Fusion Gene ORF analysis for HCG18-MAP2K4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000412685ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3CDSENST00000412685ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
5UTR-3CDSENST00000412685ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3CDSENST00000412685ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
5UTR-3CDSENST00000426882ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3CDSENST00000426882ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
5UTR-3CDSENST00000426882ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3CDSENST00000426882ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
5UTR-3CDSENST00000438412ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3CDSENST00000438412ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
5UTR-3CDSENST00000438412ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3CDSENST00000438412ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
5UTR-3UTRENST00000412685ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3UTRENST00000412685ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
5UTR-3UTRENST00000426882ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3UTRENST00000426882ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
5UTR-3UTRENST00000438412ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
5UTR-3UTRENST00000438412ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000413358ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000413358ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000413358ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000413358ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000416289ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000416289ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000416289ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000416289ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000421520ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000421520ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000421520ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000421520ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000432895ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000432895ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000432895ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000432895ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000443079ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000443079ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000443079ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000443079ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000443909ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000443909ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000443909ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000443909ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000444126ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000444126ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000444126ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000444126ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000449544ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000449544ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000449544ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000449544ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000454129ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000454129ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000454129ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000454129ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000454269ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000454269ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000454269ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000454269ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000458584ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000458584ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000458584ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000458584ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000602290ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602290ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000602290ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602290ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000602319ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602319ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000602319ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602319ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000602498ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602498ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000602498ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602498ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000602516ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602516ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000602516ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602516ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000602550ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602550ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000602550ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602550ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000602591ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602591ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000602591ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602591ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000602698ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602698ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000602698ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602698ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000602861ENST00000353533HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602861ENST00000353533HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3CDSENST00000602861ENST00000415385HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3CDSENST00000602861ENST00000415385HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000413358ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000413358ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000416289ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000416289ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000421520ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000421520ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000432895ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000432895ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000443079ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000443079ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000443909ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000443909ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000444126ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000444126ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000449544ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000449544ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000454129ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000454129ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000454269ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000454269ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000458584ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000458584ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000602290ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000602290ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000602319ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000602319ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000602498ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000602498ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000602516ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000602516ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000602550ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000602550ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000602591ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000602591ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000602698ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000602698ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+
intron-3UTRENST00000602861ENST00000581941HCG18chr6

30294131

-MAP2K4chr17

12011107

+
intron-3UTRENST00000602861ENST00000581941HCG18chr6

30294130

-MAP2K4chr17

12011106

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for HCG18-MAP2K4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HCG18chr630294130-MAP2K4chr1712011106+0.0005454850.99945456
HCG18chr630294130-MAP2K4chr1712011106+0.0005454850.99945456
HCG18chr630294130-MAP2K4chr1712011106+0.0005454850.99945456
HCG18chr630294130-MAP2K4chr1712011106+0.0005454850.99945456


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for HCG18-MAP2K4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:30294131/:12011107)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HCG18-MAP2K4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HCG18-MAP2K4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HCG18-MAP2K4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HCG18-MAP2K4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource