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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MBP-AEBP2 (FusionGDB2 ID:HG4155TG121536)

Fusion Gene Summary for MBP-AEBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: MBP-AEBP2
Fusion gene ID: hg4155tg121536
HgeneTgene
Gene symbol

MBP

AEBP2

Gene ID

4155

121536

Gene namemyelin basic proteinAE binding protein 2
Synonyms--
Cytomap('MBP')('AEBP2')

18q23

12p12.3

Type of geneprotein-codingprotein-coding
Descriptionmyelin basic proteinGolli-MBPproline-rich proteoglycan 2myelin A1 proteinmyelin membrane encephalitogenic proteinzinc finger protein AEBP2AE(adipocyte enhancer)-binding protein 2adipocyte enhancer-binding protein 2
Modification date2020031320200313
UniProtAcc

P02686

Q6ZN18

Ensembl transtripts involved in fusion geneENST00000355994, ENST00000397860, 
ENST00000397863, ENST00000579129, 
ENST00000580402, ENST00000487778, 
ENST00000354542, ENST00000359645, 
ENST00000382582, ENST00000397865, 
ENST00000397866, ENST00000397869, 
ENST00000397875, ENST00000526111, 
ENST00000527041, ENST00000528160, 
ENST00000578193, 
Fusion gene scores* DoF score26 X 20 X 7=364011 X 13 X 6=858
# samples 2615
** MAII scorelog2(26/3640*10)=-3.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/858*10)=-2.51601514700366
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MBP [Title/Abstract] AND AEBP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMBP(74778254)-AEBP2(19705787), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMBP

GO:0000165

MAPK cascade

22524708

HgeneMBP

GO:0034115

negative regulation of heterotypic cell-cell adhesion

22524708

HgeneMBP

GO:0035633

maintenance of permeability of blood-brain barrier

22524708

HgeneMBP

GO:1904209

positive regulation of chemokine (C-C motif) ligand 2 secretion

22524708

HgeneMBP

GO:1904685

positive regulation of metalloendopeptidase activity

22524708

HgeneMBP

GO:2000778

positive regulation of interleukin-6 secretion

22524708



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2754-01AMBPchr18

74778254

-AEBP2chr12

19705787

+


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Fusion Gene ORF analysis for MBP-AEBP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000355994ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000355994ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000355994ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000355994ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000397860ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000397860ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000397860ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000397860ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000397863ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000397863ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000397863ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000397863ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000579129ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000579129ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000579129ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000579129ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000580402ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000580402ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000580402ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
5CDS-intronENST00000580402ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
5UTR-intronENST00000487778ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
5UTR-intronENST00000487778ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
5UTR-intronENST00000487778ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
5UTR-intronENST00000487778ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000354542ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000354542ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000354542ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000354542ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000359645ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000359645ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000359645ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000359645ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000382582ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000382582ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000382582ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000382582ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397865ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397865ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397865ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397865ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397866ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397866ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397866ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397866ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397869ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397869ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397869ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397869ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397875ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397875ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397875ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000397875ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000526111ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000526111ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000526111ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000526111ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000527041ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000527041ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000527041ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000527041ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000528160ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000528160ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000528160ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000528160ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000578193ENST00000266508MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000578193ENST00000360995MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000578193ENST00000398864MBPchr18

74778254

-AEBP2chr12

19705787

+
intron-intronENST00000578193ENST00000541908MBPchr18

74778254

-AEBP2chr12

19705787

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MBP-AEBP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for MBP-AEBP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:74778254/:19705787)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MBP

P02686

AEBP2

Q6ZN18

FUNCTION: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}.FUNCTION: Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:31959557, PubMed:29499137). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MBP-AEBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MBP-AEBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MBP-AEBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MBP-AEBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMBPC0036341Schizophrenia4PSYGENET
HgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
HgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneMBPC0011303Demyelinating Diseases1CTD_human
HgeneMBPC0011304Demyelination1CTD_human
HgeneMBPC0027873Neuromyelitis Optica1CTD_human
HgeneMBPC2350037Clinically Isolated Syndrome, CNS Demyelinating1CTD_human