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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MBP-FEZ1 (FusionGDB2 ID:HG4155TG9638) |
Fusion Gene Summary for MBP-FEZ1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MBP-FEZ1 | Fusion gene ID: hg4155tg9638 | Hgene | Tgene | Gene symbol | MBP | FEZ1 | Gene ID | 4155 | 9638 |
| Gene name | myelin basic protein | fasciculation and elongation protein zeta 1 | |
| Synonyms | - | UNC-76 | |
| Cytomap | ('MBP')('FEZ1') 18q23 | 11q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myelin basic proteinGolli-MBPproline-rich proteoglycan 2myelin A1 proteinmyelin membrane encephalitogenic protein | fasciculation and elongation protein zeta-1zygin Izygin-1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P02686 | Q99689 | |
| Ensembl transtripts involved in fusion gene | ENST00000354542, ENST00000355994, ENST00000359645, ENST00000382582, ENST00000397860, ENST00000397863, ENST00000397865, ENST00000397866, ENST00000397869, ENST00000397875, ENST00000487778, ENST00000526111, ENST00000527041, ENST00000528160, ENST00000578193, ENST00000579129, ENST00000580402, | ||
| Fusion gene scores | * DoF score | 26 X 20 X 7=3640 | 9 X 8 X 4=288 |
| # samples | 26 | 9 | |
| ** MAII score | log2(26/3640*10)=-3.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MBP [Title/Abstract] AND FEZ1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MBP(74691842)-FEZ1(125351471), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MBP | GO:0000165 | MAPK cascade | 22524708 |
| Hgene | MBP | GO:0034115 | negative regulation of heterotypic cell-cell adhesion | 22524708 |
| Hgene | MBP | GO:0035633 | maintenance of permeability of blood-brain barrier | 22524708 |
| Hgene | MBP | GO:1904209 | positive regulation of chemokine (C-C motif) ligand 2 secretion | 22524708 |
| Hgene | MBP | GO:1904685 | positive regulation of metalloendopeptidase activity | 22524708 |
| Hgene | MBP | GO:2000778 | positive regulation of interleukin-6 secretion | 22524708 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for MBP-FEZ1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for MBP-FEZ1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for MBP-FEZ1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:74691842/:125351471) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MBP | FEZ1 |
| FUNCTION: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}. | FUNCTION: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. {ECO:0000269|PubMed:20812761, ECO:0000269|PubMed:22354037}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for MBP-FEZ1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for MBP-FEZ1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MBP-FEZ1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MBP-FEZ1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MBP | C0036341 | Schizophrenia | 4 | PSYGENET |
| Hgene | MBP | C0014072 | Experimental Autoimmune Encephalomyelitis | 3 | CTD_human |
| Hgene | MBP | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Hgene | MBP | C0011303 | Demyelinating Diseases | 1 | CTD_human |
| Hgene | MBP | C0011304 | Demyelination | 1 | CTD_human |
| Hgene | MBP | C0027873 | Neuromyelitis Optica | 1 | CTD_human |
| Hgene | MBP | C2350037 | Clinically Isolated Syndrome, CNS Demyelinating | 1 | CTD_human |
| Tgene | C0036341 | Schizophrenia | 3 | PSYGENET | |
| Tgene | C0033975 | Psychotic Disorders | 1 | PSYGENET |
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