Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MDM2-EGFR (FusionGDB2 ID:HG4193TG1956)

Fusion Gene Summary for MDM2-EGFR

Fusion gene summary

Fusion gene information	Fusion gene name: MDM2-EGFR
	Fusion gene ID: hg4193tg1956
		Hgene	Tgene
	Gene symbol	MDM2	EGFR
	Gene ID	4193	1956
	Gene name	MDM2 proto-oncogene	epidermal growth factor receptor
	Synonyms	ACTFS\|HDMX\|LSKB\|hdm2	ERBB\|ERBB1\|HER1\|NISBD2\|PIG61\|mENA
	Cytomap	('MDM2')('EGFR') 12q15	7p11.2
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hum	epidermal growth factor receptoravian erythroblastic leukemia viral (v-erb-b) oncogene homologcell growth inhibiting protein 40cell proliferation-inducing protein 61epidermal growth factor receptor tyrosine kinase domainerb-b2 receptor tyrosine kinas
	Modification date	20200329	20200329
	UniProtAcc	Q00987	.
	Ensembl transtripts involved in fusion gene	ENST00000258148, ENST00000258149, ENST00000299252, ENST00000348801, ENST00000350057, ENST00000356290, ENST00000360430, ENST00000393410, ENST00000393412, ENST00000393413, ENST00000428863, ENST00000462284, ENST00000478070, ENST00000517852, ENST00000540827, ENST00000544561, ENST00000545204, ENST00000544125,
Fusion gene scores	* DoF score	39 X 20 X 11=8580	17 X 20 X 8=2720
	# samples	47	22
	** MAII score	log2(47/8580*10)=-4.19024498582191 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/2720*10)=-3.62803122261304 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MDM2 [Title/Abstract] AND EGFR [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MDM2(69203072)-EGFR(55231426), # samples:2
Anticipated loss of major functional domain due to fusion event.	MDM2-EGFR seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. MDM2-EGFR seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. MDM2-EGFR seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. MDM2-EGFR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. MDM2-EGFR seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MDM2	GO:0000122	negative regulation of transcription by RNA polymerase II	9271120\|17310983
Hgene	MDM2	GO:0006511	ubiquitin-dependent protein catabolic process	11278372\|15314173\|16173922\|17310983
Hgene	MDM2	GO:0016567	protein ubiquitination	9450543\|15878855\|19656744\|20153724
Hgene	MDM2	GO:0031648	protein destabilization	9529249\|10360174\|15314173
Hgene	MDM2	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	11278372
Hgene	MDM2	GO:0034504	protein localization to nucleus	10360174
Hgene	MDM2	GO:0042176	regulation of protein catabolic process	9153395
Hgene	MDM2	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	9529249\|10360174
Hgene	MDM2	GO:0045184	establishment of protein localization	10360174
Hgene	MDM2	GO:0045892	negative regulation of transcription, DNA-templated	9271120
Hgene	MDM2	GO:0065003	protein-containing complex assembly	10608892\|12915590
Hgene	MDM2	GO:0071157	negative regulation of cell cycle arrest	9529249
Hgene	MDM2	GO:0071480	cellular response to gamma radiation	16213212
Hgene	MDM2	GO:0072717	cellular response to actinomycin D	15314173
Hgene	MDM2	GO:1901797	negative regulation of signal transduction by p53 class mediator	16173922
Tgene	EGFR	GO:0001934	positive regulation of protein phosphorylation	20551055
Tgene	EGFR	GO:0007165	signal transduction	10572067
Tgene	EGFR	GO:0007166	cell surface receptor signaling pathway	7736574
Tgene	EGFR	GO:0007173	epidermal growth factor receptor signaling pathway	7736574\|12435727
Tgene	EGFR	GO:0008283	cell proliferation	17115032
Tgene	EGFR	GO:0008284	positive regulation of cell proliferation	7736574
Tgene	EGFR	GO:0010750	positive regulation of nitric oxide mediated signal transduction	12828935
Tgene	EGFR	GO:0018108	peptidyl-tyrosine phosphorylation	22732145
Tgene	EGFR	GO:0030307	positive regulation of cell growth	15467833
Tgene	EGFR	GO:0042177	negative regulation of protein catabolic process	17115032
Tgene	EGFR	GO:0042327	positive regulation of phosphorylation	15082764
Tgene	EGFR	GO:0043406	positive regulation of MAP kinase activity	10572067
Tgene	EGFR	GO:0045739	positive regulation of DNA repair	17115032
Tgene	EGFR	GO:0045740	positive regulation of DNA replication	17115032
Tgene	EGFR	GO:0045944	positive regulation of transcription by RNA polymerase II	20551055
Tgene	EGFR	GO:0050679	positive regulation of epithelial cell proliferation	10572067
Tgene	EGFR	GO:0050999	regulation of nitric-oxide synthase activity	12828935
Tgene	EGFR	GO:0070141	response to UV-A	18483258
Tgene	EGFR	GO:0070374	positive regulation of ERK1 and ERK2 cascade	20551055
Tgene	EGFR	GO:0071392	cellular response to estradiol stimulus	20551055
Tgene	EGFR	GO:1900020	positive regulation of protein kinase C activity	22732145
Tgene	EGFR	GO:1903078	positive regulation of protein localization to plasma membrane	22732145

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-19-2624-01A	MDM2	chr12	69203072	-	EGFR	chr7	55231426	+
ChimerDB4	GBM	TCGA-19-2624-01A	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
ChimerDB4	GBM	TCGA-19-2624	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+

Top

Fusion Gene ORF analysis for MDM2-EGFR

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000258148	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258148	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258148	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258148	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258148	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258148	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258148	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258148	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258148	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258148	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258149	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258149	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258149	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258149	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258149	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258149	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258149	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258149	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000258149	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000258149	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000299252	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000299252	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000299252	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000299252	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000299252	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000299252	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000299252	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000299252	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000299252	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000299252	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000348801	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000348801	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000348801	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000348801	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000348801	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000348801	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000348801	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000348801	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000348801	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000348801	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000350057	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000350057	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000350057	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000350057	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000350057	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000350057	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000350057	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000350057	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000350057	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000350057	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000356290	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000356290	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000356290	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000356290	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000356290	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000356290	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000356290	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000356290	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000356290	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000356290	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000360430	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000360430	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000360430	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000360430	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000360430	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000360430	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000360430	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000360430	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000360430	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000360430	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393410	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393410	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393410	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393410	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393410	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393410	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393410	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393410	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393410	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393410	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393412	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393412	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393412	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393412	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393412	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393412	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393412	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393412	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393412	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393412	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393413	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393413	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393413	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393413	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393413	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393413	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393413	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393413	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000393413	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000393413	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000428863	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000428863	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000428863	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000428863	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000428863	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000428863	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000428863	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000428863	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000428863	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000428863	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000462284	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000462284	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000462284	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000462284	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000462284	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000462284	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000462284	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000462284	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000462284	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000462284	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000478070	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000478070	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000478070	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000478070	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000478070	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000478070	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000478070	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000478070	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000478070	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000478070	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000517852	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000517852	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000517852	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000517852	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000517852	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000517852	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000517852	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000517852	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000517852	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000517852	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000540827	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000540827	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000540827	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000540827	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000540827	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000540827	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000540827	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000540827	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000540827	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000540827	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000544561	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000544561	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000544561	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000544561	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000544561	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000544561	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000544561	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000544561	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000544561	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000544561	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000545204	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000545204	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000545204	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000545204	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000545204	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000545204	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000545204	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000545204	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
5CDS-intron	ENST00000545204	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
5CDS-intron	ENST00000545204	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000258148	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000258148	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000258148	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000258148	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000258148	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000258148	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000258149	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000258149	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000258149	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000258149	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000258149	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000258149	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000299252	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000299252	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000299252	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000299252	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000299252	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000299252	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000348801	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000348801	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000348801	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000348801	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000348801	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000348801	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000350057	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000350057	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000350057	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000350057	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000350057	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000350057	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000356290	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000356290	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000356290	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000356290	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000356290	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000356290	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000360430	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000360430	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000360430	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000360430	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000360430	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000360430	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393410	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393410	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393410	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393410	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393410	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393410	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393412	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393412	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393412	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393412	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393412	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393412	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393413	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393413	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393413	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393413	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000393413	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000393413	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000428863	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000428863	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000428863	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000428863	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000428863	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000428863	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000462284	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000462284	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000462284	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000462284	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000462284	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000462284	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000478070	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000478070	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000478070	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000478070	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000478070	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000478070	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000517852	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000517852	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000517852	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000517852	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000517852	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000517852	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000540827	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000540827	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000540827	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000540827	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000540827	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000540827	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000544561	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000544561	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000544561	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000544561	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000544561	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000544561	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000545204	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000545204	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000545204	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000545204	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
Frame-shift	ENST00000545204	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
Frame-shift	ENST00000545204	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
intron-3CDS	ENST00000544125	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
intron-3CDS	ENST00000544125	ENST00000342916	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
intron-3CDS	ENST00000544125	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
intron-3CDS	ENST00000544125	ENST00000344576	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
intron-3CDS	ENST00000544125	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
intron-3CDS	ENST00000544125	ENST00000455089	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
intron-intron	ENST00000544125	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
intron-intron	ENST00000544125	ENST00000275493	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
intron-intron	ENST00000544125	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
intron-intron	ENST00000544125	ENST00000420316	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
intron-intron	ENST00000544125	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
intron-intron	ENST00000544125	ENST00000442591	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
intron-intron	ENST00000544125	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
intron-intron	ENST00000544125	ENST00000454757	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+
intron-intron	ENST00000544125	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231426	+
intron-intron	ENST00000544125	ENST00000463948	MDM2	chr12	69203072	+	EGFR	chr7	55231425	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for MDM2-EGFR

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MDM2-EGFR

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:69203072/:55231426)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MDM2 Q00987	.
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250\|UniProtKB:P23804, ECO:0000269\|PubMed:12821780, ECO:0000269\|PubMed:15053880, ECO:0000269\|PubMed:15195100, ECO:0000269\|PubMed:15632057, ECO:0000269\|PubMed:16337594, ECO:0000269\|PubMed:17290220, ECO:0000269\|PubMed:19098711, ECO:0000269\|PubMed:19219073, ECO:0000269\|PubMed:19837670, ECO:0000269\|PubMed:19965871, ECO:0000269\|PubMed:20173098, ECO:0000269\|PubMed:20385133, ECO:0000269\|PubMed:20858735, ECO:0000269\|PubMed:22128911, ECO:0000269\|PubMed:30879903}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for MDM2-EGFR

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for MDM2-EGFR

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MDM2-EGFR

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	MDM2	Q00987	DB14548	Zinc sulfate, unspecified form	Binder	Small molecule	Approved\|Experimental
Hgene	MDM2	Q00987	DB01593	Zinc		Small molecule	Approved\|Investigational
Hgene	MDM2	Q00987	DB14487	Zinc acetate		Small molecule	Approved\|Investigational
Hgene	MDM2	Q00987	DB14533	Zinc chloride	Binder	Small molecule	Approved\|Investigational

Top

Related Diseases for MDM2-EGFR

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	MDM2	C0007131	Non-Small Cell Lung Carcinoma	2	CTD_human
Hgene	MDM2	C0006142	Malignant neoplasm of breast	1	CTD_human
Hgene	MDM2	C0007621	Neoplastic Cell Transformation	1	CTD_human
Hgene	MDM2	C0019693	HIV Infections	1	CTD_human
Hgene	MDM2	C0021364	Male infertility	1	CTD_human
Hgene	MDM2	C0025202	melanoma	1	CTD_human
Hgene	MDM2	C0032927	Precancerous Conditions	1	CTD_human
Hgene	MDM2	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	MDM2	C0085390	Li-Fraumeni Syndrome	1	ORPHANET
Hgene	MDM2	C0263859	Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome	1	CTD_human
Hgene	MDM2	C0282313	Condition, Preneoplastic	1	CTD_human
Hgene	MDM2	C0376358	Malignant neoplasm of prostate	1	CTD_human
Hgene	MDM2	C0678222	Breast Carcinoma	1	CTD_human
Hgene	MDM2	C0848676	Subfertility, Male	1	CTD_human
Hgene	MDM2	C0917731	Male sterility	1	CTD_human
Hgene	MDM2	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	MDM2	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	MDM2	C4505456	HIV Coinfection	1	CTD_human
Hgene	MDM2	C4704874	Mammary Carcinoma, Human	1	CTD_human
Tgene		C0007131	Non-Small Cell Lung Carcinoma	16	CGI;CTD_human
Tgene		C0024121	Lung Neoplasms	7	CGI;CTD_human
Tgene		C0242379	Malignant neoplasm of lung	7	CGI;CTD_human
Tgene		C0006142	Malignant neoplasm of breast	6	CTD_human
Tgene		C0678222	Breast Carcinoma	6	CTD_human
Tgene		C1257931	Mammary Neoplasms, Human	6	CTD_human
Tgene		C1458155	Mammary Neoplasms	6	CTD_human
Tgene		C4704874	Mammary Carcinoma, Human	6	CTD_human
Tgene		C0001418	Adenocarcinoma	5	CTD_human
Tgene		C0205641	Adenocarcinoma, Basal Cell	5	CTD_human
Tgene		C0205642	Adenocarcinoma, Oxyphilic	5	CTD_human
Tgene		C0205643	Carcinoma, Cribriform	5	CTD_human
Tgene		C0205644	Carcinoma, Granular Cell	5	CTD_human
Tgene		C0205645	Adenocarcinoma, Tubular	5	CTD_human
Tgene		C0334588	Giant Cell Glioblastoma	5	CTD_human;ORPHANET
Tgene		C0007137	Squamous cell carcinoma	3	CTD_human
Tgene		C0007873	Uterine Cervical Neoplasm	3	CTD_human
Tgene		C0014859	Esophageal Neoplasms	3	CGI;CTD_human
Tgene		C0017636	Glioblastoma	3	CGI;CTD_human
Tgene		C0018671	Head and Neck Neoplasms	3	CGI;CTD_human
Tgene		C0018675	Head Neoplasms	3	CTD_human
Tgene		C0024623	Malignant neoplasm of stomach	3	CTD_human
Tgene		C0027533	Neck Neoplasms	3	CTD_human
Tgene		C0027627	Neoplasm Metastasis	3	CTD_human
Tgene		C0033578	Prostatic Neoplasms	3	CTD_human
Tgene		C0038356	Stomach Neoplasms	3	CTD_human
Tgene		C0278996	Malignant Head and Neck Neoplasm	3	CGI;CTD_human
Tgene		C0376358	Malignant neoplasm of prostate	3	CTD_human
Tgene		C0546837	Malignant neoplasm of esophagus	3	CGI;CTD_human
Tgene		C0746787	Cancer of Neck	3	CTD_human
Tgene		C0751177	Cancer of Head	3	CTD_human
Tgene		C0887900	Upper Aerodigestive Tract Neoplasms	3	CTD_human
Tgene		C1621958	Glioblastoma Multiforme	3	CTD_human
Tgene		C1708349	Hereditary Diffuse Gastric Cancer	3	CTD_human
Tgene		C4048328	cervical cancer	3	CTD_human
Tgene		C0005684	Malignant neoplasm of urinary bladder	2	CTD_human
Tgene		C0005695	Bladder Neoplasm	2	CTD_human
Tgene		C0007102	Malignant tumor of colon	2	CTD_human
Tgene		C0009375	Colonic Neoplasms	2	CTD_human
Tgene		C0009402	Colorectal Carcinoma	2	CTD_human
Tgene		C0009404	Colorectal Neoplasms	2	CTD_human
Tgene		C0024668	Mammary Neoplasms, Experimental	2	CTD_human
Tgene		C0027626	Neoplasm Invasiveness	2	CTD_human
Tgene		C0027643	Neoplasm Recurrence, Local	2	CTD_human
Tgene		C0152013	Adenocarcinoma of lung (disorder)	2	CGI;CTD_human
Tgene		C0206726	gliosarcoma	2	ORPHANET
Tgene		C0919267	ovarian neoplasm	2	CTD_human
Tgene		C1140680	Malignant neoplasm of ovary	2	CTD_human
Tgene		C4015130	INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL, 2	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene		C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Tgene		C0003865	Arthritis, Adjuvant-Induced	1	CTD_human
Tgene		C0005396	Bile Duct Neoplasms	1	CTD_human
Tgene		C0007097	Carcinoma	1	CTD_human
Tgene		C0007113	Rectal Carcinoma	1	CTD_human
Tgene		C0007193	Cardiomyopathy, Dilated	1	CTD_human
Tgene		C0011603	Dermatitis	1	CTD_human
Tgene		C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
Tgene		C0014175	Endometriosis	1	CTD_human
Tgene		C0016978	gallbladder neoplasm	1	CTD_human
Tgene		C0021655	Insulin Resistance	1	CTD_human
Tgene		C0022660	Kidney Failure, Acute	1	CTD_human
Tgene		C0024667	Animal Mammary Neoplasms	1	CTD_human
Tgene		C0024809	Marijuana Abuse	1	PSYGENET
Tgene		C0025500	Mesothelioma	1	CTD_human
Tgene		C0027439	Nasopharyngeal Neoplasms	1	CTD_human
Tgene		C0029463	Osteosarcoma	1	CTD_human
Tgene		C0030297	Pancreatic Neoplasm	1	CTD_human
Tgene		C0030354	Papilloma	1	CTD_human
Tgene		C0032580	Adenomatous Polyposis Coli	1	CTD_human
Tgene		C0034885	Rectal Neoplasms	1	CTD_human
Tgene		C0041696	Unipolar Depression	1	PSYGENET
Tgene		C0085548	Autosomal Recessive Polycystic Kidney Disease	1	CTD_human
Tgene		C0085762	Alcohol abuse	1	PSYGENET
Tgene		C0149925	Small cell carcinoma of lung	1	CTD_human
Tgene		C0153452	Malignant neoplasm of gallbladder	1	CTD_human
Tgene		C0205696	Anaplastic carcinoma	1	CTD_human
Tgene		C0205697	Carcinoma, Spindle-Cell	1	CTD_human
Tgene		C0205698	Undifferentiated carcinoma	1	CTD_human
Tgene		C0205699	Carcinomatosis	1	CTD_human
Tgene		C0205874	Papilloma, Squamous Cell	1	CTD_human
Tgene		C0205875	Papillomatosis	1	CTD_human
Tgene		C0206686	Adrenocortical carcinoma	1	CTD_human
Tgene		C0206698	Cholangiocarcinoma	1	CTD_human
Tgene		C0235874	Disease Exacerbation	1	CTD_human
Tgene		C0238301	Cancer of Nasopharynx	1	CTD_human
Tgene		C0263454	Chloracne	1	CTD_human
Tgene		C0269102	Endometrioma	1	CTD_human
Tgene		C0279626	Squamous cell carcinoma of esophagus	1	CGI;CTD_human
Tgene		C0345905	Intrahepatic Cholangiocarcinoma	1	CTD_human
Tgene		C0345967	Malignant mesothelioma	1	CTD_human
Tgene		C0346647	Malignant neoplasm of pancreas	1	CTD_human
Tgene		C0376634	Craniofacial Abnormalities	1	CTD_human
Tgene		C0740277	Bile duct carcinoma	1	CTD_human
Tgene		C0920563	Insulin Sensitivity	1	CTD_human
Tgene		C0971858	Arthritis, Collagen-Induced	1	CTD_human
Tgene		C0993582	Arthritis, Experimental	1	CTD_human
Tgene		C1257925	Mammary Carcinoma, Animal	1	CTD_human
Tgene		C1269683	Major Depressive Disorder	1	PSYGENET
Tgene		C1449563	Cardiomyopathy, Familial Idiopathic	1	CTD_human
Tgene		C1565662	Acute Kidney Insufficiency	1	CTD_human
Tgene		C2239176	Liver carcinoma	1	CTD_human
Tgene		C2609414	Acute kidney injury	1	CTD_human
Tgene		C2713442	Polyposis, Adenomatous Intestinal	1	CTD_human
Tgene		C2713443	Familial Intestinal Polyposis	1	CTD_human
Tgene		C3805278	Extrahepatic Cholangiocarcinoma	1	CTD_human
Tgene		C4751120	Neonatal inflammatory skin and bowel disease	1	ORPHANET

Fusion Gene Studies in Kim Lab

Fusion gene:MDM2-EGFR (FusionGDB2 ID:HG4193TG1956)

Fusion Gene Summary for MDM2-EGFR

Fusion Gene ORF analysis for MDM2-EGFR

Fusion Genomic Features for MDM2-EGFR

Fusion Protein Features for MDM2-EGFR

Fusion Gene Sequence for MDM2-EGFR

Fusion Gene PPI Analysis for MDM2-EGFR

Related Drugs for MDM2-EGFR

Related Diseases for MDM2-EGFR

Fusion Gene Studies
in Kim Lab