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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CD99-DHRSX (FusionGDB2 ID:HG4267TG207063)

Fusion Gene Summary for CD99-DHRSX

check button Fusion gene summary
Fusion gene informationFusion gene name: CD99-DHRSX
Fusion gene ID: hg4267tg207063
HgeneTgene
Gene symbol

CD99

DHRSX

Gene ID

4267

207063

Gene nameCD99 molecule (Xg blood group)dehydrogenase/reductase X-linked
SynonymsHBA71|MIC2|MIC2X|MIC2Y|MSK5XCXorf11|DHRS5X|DHRS5Y|DHRSXY|DHRSY|SDR46C1|SDR7C6
Cytomap('CD99')('DHRSX')

Xp22.33 and Yp11.2

Xp22.33 and Yp11.2

Type of geneprotein-codingprotein-coding
DescriptionCD99 antigenE2 antigenMIC2 (monoclonal antibody 12E7)T-cell surface glycoprotein E2antigen identified by monoclonal 12E7, Y homologantigen identified by monoclonal antibodies 12E7, F21 and O13cell surface antigen 12E7cell surface antigen HBA-71celdehydrogenase/reductase SDR family member on chromosome Xdehydrogenase/reductase (SDR family) X chromosomedehydrogenase/reductase (SDR family) X-linkeddehydrogenase/reductase (SDR family) Y-linkedshort chain dehydrogenase/reductase family 46C member 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000482405, ENST00000381180, 
ENST00000381184, ENST00000381187, 
ENST00000381192, 
Fusion gene scores* DoF score16 X 8 X 2=25617 X 16 X 8=2176
# samples 1617
** MAII scorelog2(16/256*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(17/2176*10)=-3.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD99 [Title/Abstract] AND DHRSX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCD99(2559468)-DHRSX(2159644), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CD99 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DHRSX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-7299CD99chrY

2559468

+DHRSXchrY

2159644

-


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Fusion Gene ORF analysis for CD99-DHRSX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000482405ENST00000334651CD99chrY

2559468

+DHRSXchrY

2159644

-
3UTR-intronENST00000482405ENST00000464935CD99chrY

2559468

+DHRSXchrY

2159644

-
5CDS-intronENST00000381180ENST00000464935CD99chrY

2559468

+DHRSXchrY

2159644

-
5CDS-intronENST00000381184ENST00000464935CD99chrY

2559468

+DHRSXchrY

2159644

-
5CDS-intronENST00000381187ENST00000464935CD99chrY

2559468

+DHRSXchrY

2159644

-
5CDS-intronENST00000381192ENST00000464935CD99chrY

2559468

+DHRSXchrY

2159644

-
In-frameENST00000381180ENST00000334651CD99chrY

2559468

+DHRSXchrY

2159644

-
In-frameENST00000381184ENST00000334651CD99chrY

2559468

+DHRSXchrY

2159644

-
In-frameENST00000381187ENST00000334651CD99chrY

2559468

+DHRSXchrY

2159644

-
In-frameENST00000381192ENST00000334651CD99chrY

2559468

+DHRSXchrY

2159644

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000381192CD99chrY2559468+ENST00000334651DHRSXchrY2159644-2481249143955270
ENST00000381187CD99chrY2559468+ENST00000334651DHRSXchrY2159644-238415246858270
ENST00000381184CD99chrY2559468+ENST00000334651DHRSXchrY2159644-238014842854270
ENST00000381180CD99chrY2559468+ENST00000334651DHRSXchrY2159644-2299670773257

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381192ENST00000334651CD99chrY2559468+DHRSXchrY2159644-0.0009858170.99901414
ENST00000381187ENST00000334651CD99chrY2559468+DHRSXchrY2159644-0.0009066590.9990933
ENST00000381184ENST00000334651CD99chrY2559468+DHRSXchrY2159644-0.0009876120.99901235
ENST00000381180ENST00000334651CD99chrY2559468+DHRSXchrY2159644-0.0008757890.9991242

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Fusion Genomic Features for CD99-DHRSX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CD99-DHRSX


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrY:2559468/chrY:2159644)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD99chrY:2559468chrY:2159644ENST00000381187+19148_18522170.0Topological domainCytoplasmic
HgeneCD99chrY:2559468chrY:2159644ENST00000381187+1923_12222170.0Topological domainExtracellular
HgeneCD99chrY:2559468chrY:2159644ENST00000381192+110148_18522186.0Topological domainCytoplasmic
HgeneCD99chrY:2559468chrY:2159644ENST00000381192+11023_12222186.0Topological domainExtracellular
HgeneCD99chrY:2559468chrY:2159644ENST00000381187+19123_14722170.0TransmembraneHelical
HgeneCD99chrY:2559468chrY:2159644ENST00000381192+110123_14722186.0TransmembraneHelical
TgeneDHRSXchrY:2559468chrY:2159644ENST000003346512747_7195331.0Nucleotide bindingNAD or NADP


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Fusion Gene Sequence for CD99-DHRSX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14713_14713_1_CD99-DHRSX_CD99_chrY_2559468_ENST00000381180_DHRSX_chrY_2159644_ENST00000334651_length(transcript)=2299nt_BP=67nt
ATGGCCCGCGGGGCTGCGCTGGCGCTGCTGCTCTTCGGCCTGCTGGGTGTTCTGGTCGCCGCCCCGGTGGAATTTTTATACTGTGACTTG
GCTTCCATGACTTCCATCCGGCAGTTTGTGCAGAAGTTCAAGATGAAGAAGATTCCTCTCCATGTCCTGATCAACAATGCTGGGGTGATG
ATGGTCCCTCAGAGGAAAACCAGAGATGGATTCGAAGAACATTTCGGCCTGAACTACCTAGGGCACTTCCTGCTGACCAACCTTCTCTTG
GATACGCTGAAAGAGTCTGGGTCCCCTGGCCACAGTGCGAGGGTGGTCACCGTCTCCTCTGCCACCCATTACGTCGCTGAGCTGAACATG
GATGACCTTCAGAGCAGTGCCTGCTACTCACCCCACGCAGCCTACGCCCAGAGCAAGCTGGCCCTTGTCCTGTTCACCTACCACCTCCAG
CGGCTGCTGGCGGCTGAGGGAAGCCACGTGACCGCCAACGTGGTGGACCCCGGGGTGGTCAACACGGACGTCTACAAGCACGTGTTCTGG
GCCACCCGTCTGGCGAAGAAGCTTCTCGGCTGGTTGCTTTTCAAGACCCCCGATGAAGGAGCGTGGACTTCCATCTACGCAGCAGTCACC
CCAGAGCTGGAAGGAGTTGGTGGCCATTACCTATACAACGAGAAAGAGACCAAGTCCCTCCACGTCACCTACAACCAGAAACTGCAGCAG
CAGCTGTGGTCTAAGAGTTGTGAGATGACTGGGGTCCTTGATGTGACCCTGTGATATCCTGTCTCAGGATAGCTGCTGCCCCAAGAAACA
CATTGCACCTGCCAATAGCTTGTGGGTCTGTGAAGACTGCGGTGTTTGAGTTTCTCACACCCACCTGCCCACAGGGCTCTGTCCTCTAGT
TTTGAGACAGCTGCCTCAACCTCTGCAGAACTTCAAGAAGCCAAATAAACATTTTGGAGGATAATCACCCCAAGTGGTCTTCAACCATAA
ACTTTGTGATTCCAAAGTGCCCAGTTGTCACAGGTGCCATAAATAATTACATTTTCCAACATAAATGTGCCATTTTCCTTGCCGCGTTAA
TACAACTGAGTACAAAAGTTCCAAGAGAGATGCTCTCTTTTCAGGGGCTGCAATGTCCTCTCTGAGACCTAGTGGTGGATGAGGTCTCCT
GTTTGATTTTGTTCCTGCACTCACTCATTTTTCCAGAGACCCAGCTGTGATTCACAGGTGTCAGACATGGGGAGGTGTGAGCCTTGCTTG
CTACAGCCTGTAGGATGAGTTTGACGTGGCCAGCAGCACCATCTGGTCAACCTCATTCCAGAATGGCACAGTCACAAGTGAAGCATGCCA
CTGTCAAATCCGAGAATGTAAACCGCTGAACAGCTATGGATCAAATGGTAGCCCTCAAAAGATATGTTCATGCCCTAACCCTCAGAACCT
ATAAATATTACTTTATTTGGAAAAGAATCTTTGCAGATAGAATTAAGAATTTTGAGATGGGTCATTATGGATCATCCCAGTGAACCTAAT
GCCATCACGAGGGTTCTTATCAGAGACAGGTAGAGGGAGATTTGAGTACAGAAGACAAGATATTCGTGTGATGATGCAGACAGAGACTGG
AGTGATGCCACCACAAGCCAAGCAATGCCTGGAGCCACCAGGAGCTGGGACAGGCAGGAAGGATTCTCCCTTATACCCCTCAGAGCAATC
TTGGCCCCTCTGACGTCTTGACTTTAGACTTCTGGTCCCCAGAACGGAGAGAGAATAAATCTTTCTTGTTTTAAGGCTCCAACAAATTGG
TAGTCACTTGTTACAGCAACCACAGGAAATGTATACAGCTTCTGATACTTCTGAAAACCTCACACAGCCAAAGGGTACATCCTTGGTATA
GAGGCTCACTCTTACTCACCAGCCAGGCAAGGAAGGCTCAATCCTTTGGTGTTAGAGAGATAGATGTTGGGTTTTCAAATTTCAACATAG
AGAAATCAGTCATTTGCAATGCTTTTGAGAAAGTACTGTGTATACCCTACGAGCCTGCACTCCTTATGTGTGAGACTGATGACCATTGGT
TGGCTTATTATCCATTCCACTAAGTGACAAAATCCCACTGACTATTCAAATCCAGGCTCCTGGCATGCCTGTACCTTAGAATCACAACCA
GCTGCAATTCCAGGATGGAGTTCAAACTAATTGTGGGGGCATGTGCTTCTTACATGACTGCTAGATTGTTCCCAGATGGGGAAGGTTGCC

>14713_14713_1_CD99-DHRSX_CD99_chrY_2559468_ENST00000381180_DHRSX_chrY_2159644_ENST00000334651_length(amino acids)=257AA_BP=21
MARGAALALLLFGLLGVLVAAPVEFLYCDLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLL
DTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYHLQRLLAAEGSHVTANVVDPGVVNTDVYKHVFW

--------------------------------------------------------------
>14713_14713_2_CD99-DHRSX_CD99_chrY_2559468_ENST00000381184_DHRSX_chrY_2159644_ENST00000334651_length(transcript)=2380nt_BP=148nt
GGCCCGTGGGGGAGTATCTGTCCTGCCGCCTTCGCCCACGCCCTGCACTCCGGGACCGTCCCTGCGCGCTCTGGGCGCACCATGGCCCGC
GGGGCTGCGCTGGCGCTGCTGCTCTTCGGCCTGCTGGGTGTTCTGGTCGCCGCCCCGGTGGAATTTTTATACTGTGACTTGGCTTCCATG
ACTTCCATCCGGCAGTTTGTGCAGAAGTTCAAGATGAAGAAGATTCCTCTCCATGTCCTGATCAACAATGCTGGGGTGATGATGGTCCCT
CAGAGGAAAACCAGAGATGGATTCGAAGAACATTTCGGCCTGAACTACCTAGGGCACTTCCTGCTGACCAACCTTCTCTTGGATACGCTG
AAAGAGTCTGGGTCCCCTGGCCACAGTGCGAGGGTGGTCACCGTCTCCTCTGCCACCCATTACGTCGCTGAGCTGAACATGGATGACCTT
CAGAGCAGTGCCTGCTACTCACCCCACGCAGCCTACGCCCAGAGCAAGCTGGCCCTTGTCCTGTTCACCTACCACCTCCAGCGGCTGCTG
GCGGCTGAGGGAAGCCACGTGACCGCCAACGTGGTGGACCCCGGGGTGGTCAACACGGACGTCTACAAGCACGTGTTCTGGGCCACCCGT
CTGGCGAAGAAGCTTCTCGGCTGGTTGCTTTTCAAGACCCCCGATGAAGGAGCGTGGACTTCCATCTACGCAGCAGTCACCCCAGAGCTG
GAAGGAGTTGGTGGCCATTACCTATACAACGAGAAAGAGACCAAGTCCCTCCACGTCACCTACAACCAGAAACTGCAGCAGCAGCTGTGG
TCTAAGAGTTGTGAGATGACTGGGGTCCTTGATGTGACCCTGTGATATCCTGTCTCAGGATAGCTGCTGCCCCAAGAAACACATTGCACC
TGCCAATAGCTTGTGGGTCTGTGAAGACTGCGGTGTTTGAGTTTCTCACACCCACCTGCCCACAGGGCTCTGTCCTCTAGTTTTGAGACA
GCTGCCTCAACCTCTGCAGAACTTCAAGAAGCCAAATAAACATTTTGGAGGATAATCACCCCAAGTGGTCTTCAACCATAAACTTTGTGA
TTCCAAAGTGCCCAGTTGTCACAGGTGCCATAAATAATTACATTTTCCAACATAAATGTGCCATTTTCCTTGCCGCGTTAATACAACTGA
GTACAAAAGTTCCAAGAGAGATGCTCTCTTTTCAGGGGCTGCAATGTCCTCTCTGAGACCTAGTGGTGGATGAGGTCTCCTGTTTGATTT
TGTTCCTGCACTCACTCATTTTTCCAGAGACCCAGCTGTGATTCACAGGTGTCAGACATGGGGAGGTGTGAGCCTTGCTTGCTACAGCCT
GTAGGATGAGTTTGACGTGGCCAGCAGCACCATCTGGTCAACCTCATTCCAGAATGGCACAGTCACAAGTGAAGCATGCCACTGTCAAAT
CCGAGAATGTAAACCGCTGAACAGCTATGGATCAAATGGTAGCCCTCAAAAGATATGTTCATGCCCTAACCCTCAGAACCTATAAATATT
ACTTTATTTGGAAAAGAATCTTTGCAGATAGAATTAAGAATTTTGAGATGGGTCATTATGGATCATCCCAGTGAACCTAATGCCATCACG
AGGGTTCTTATCAGAGACAGGTAGAGGGAGATTTGAGTACAGAAGACAAGATATTCGTGTGATGATGCAGACAGAGACTGGAGTGATGCC
ACCACAAGCCAAGCAATGCCTGGAGCCACCAGGAGCTGGGACAGGCAGGAAGGATTCTCCCTTATACCCCTCAGAGCAATCTTGGCCCCT
CTGACGTCTTGACTTTAGACTTCTGGTCCCCAGAACGGAGAGAGAATAAATCTTTCTTGTTTTAAGGCTCCAACAAATTGGTAGTCACTT
GTTACAGCAACCACAGGAAATGTATACAGCTTCTGATACTTCTGAAAACCTCACACAGCCAAAGGGTACATCCTTGGTATAGAGGCTCAC
TCTTACTCACCAGCCAGGCAAGGAAGGCTCAATCCTTTGGTGTTAGAGAGATAGATGTTGGGTTTTCAAATTTCAACATAGAGAAATCAG
TCATTTGCAATGCTTTTGAGAAAGTACTGTGTATACCCTACGAGCCTGCACTCCTTATGTGTGAGACTGATGACCATTGGTTGGCTTATT
ATCCATTCCACTAAGTGACAAAATCCCACTGACTATTCAAATCCAGGCTCCTGGCATGCCTGTACCTTAGAATCACAACCAGCTGCAATT
CCAGGATGGAGTTCAAACTAATTGTGGGGGCATGTGCTTCTTACATGACTGCTAGATTGTTCCCAGATGGGGAAGGTTGCCCTGATAAGC

>14713_14713_2_CD99-DHRSX_CD99_chrY_2559468_ENST00000381184_DHRSX_chrY_2159644_ENST00000334651_length(amino acids)=270AA_BP=34
MHSGTVPARSGRTMARGAALALLLFGLLGVLVAAPVEFLYCDLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGL
NYLGHFLLTNLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYHLQRLLAAEGSHVTANVVDP
GVVNTDVYKHVFWATRLAKKLLGWLLFKTPDEGAWTSIYAAVTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKSCEMTGVLDVTL

--------------------------------------------------------------
>14713_14713_3_CD99-DHRSX_CD99_chrY_2559468_ENST00000381187_DHRSX_chrY_2159644_ENST00000334651_length(transcript)=2384nt_BP=152nt
ACCCGGCCCGTGGGGGAGTATCTGTCCTGCCGCCTTCGCCCACGCCCTGCACTCCGGGACCGTCCCTGCGCGCTCTGGGCGCACCATGGC
CCGCGGGGCTGCGCTGGCGCTGCTGCTCTTCGGCCTGCTGGGTGTTCTGGTCGCCGCCCCGGTGGAATTTTTATACTGTGACTTGGCTTC
CATGACTTCCATCCGGCAGTTTGTGCAGAAGTTCAAGATGAAGAAGATTCCTCTCCATGTCCTGATCAACAATGCTGGGGTGATGATGGT
CCCTCAGAGGAAAACCAGAGATGGATTCGAAGAACATTTCGGCCTGAACTACCTAGGGCACTTCCTGCTGACCAACCTTCTCTTGGATAC
GCTGAAAGAGTCTGGGTCCCCTGGCCACAGTGCGAGGGTGGTCACCGTCTCCTCTGCCACCCATTACGTCGCTGAGCTGAACATGGATGA
CCTTCAGAGCAGTGCCTGCTACTCACCCCACGCAGCCTACGCCCAGAGCAAGCTGGCCCTTGTCCTGTTCACCTACCACCTCCAGCGGCT
GCTGGCGGCTGAGGGAAGCCACGTGACCGCCAACGTGGTGGACCCCGGGGTGGTCAACACGGACGTCTACAAGCACGTGTTCTGGGCCAC
CCGTCTGGCGAAGAAGCTTCTCGGCTGGTTGCTTTTCAAGACCCCCGATGAAGGAGCGTGGACTTCCATCTACGCAGCAGTCACCCCAGA
GCTGGAAGGAGTTGGTGGCCATTACCTATACAACGAGAAAGAGACCAAGTCCCTCCACGTCACCTACAACCAGAAACTGCAGCAGCAGCT
GTGGTCTAAGAGTTGTGAGATGACTGGGGTCCTTGATGTGACCCTGTGATATCCTGTCTCAGGATAGCTGCTGCCCCAAGAAACACATTG
CACCTGCCAATAGCTTGTGGGTCTGTGAAGACTGCGGTGTTTGAGTTTCTCACACCCACCTGCCCACAGGGCTCTGTCCTCTAGTTTTGA
GACAGCTGCCTCAACCTCTGCAGAACTTCAAGAAGCCAAATAAACATTTTGGAGGATAATCACCCCAAGTGGTCTTCAACCATAAACTTT
GTGATTCCAAAGTGCCCAGTTGTCACAGGTGCCATAAATAATTACATTTTCCAACATAAATGTGCCATTTTCCTTGCCGCGTTAATACAA
CTGAGTACAAAAGTTCCAAGAGAGATGCTCTCTTTTCAGGGGCTGCAATGTCCTCTCTGAGACCTAGTGGTGGATGAGGTCTCCTGTTTG
ATTTTGTTCCTGCACTCACTCATTTTTCCAGAGACCCAGCTGTGATTCACAGGTGTCAGACATGGGGAGGTGTGAGCCTTGCTTGCTACA
GCCTGTAGGATGAGTTTGACGTGGCCAGCAGCACCATCTGGTCAACCTCATTCCAGAATGGCACAGTCACAAGTGAAGCATGCCACTGTC
AAATCCGAGAATGTAAACCGCTGAACAGCTATGGATCAAATGGTAGCCCTCAAAAGATATGTTCATGCCCTAACCCTCAGAACCTATAAA
TATTACTTTATTTGGAAAAGAATCTTTGCAGATAGAATTAAGAATTTTGAGATGGGTCATTATGGATCATCCCAGTGAACCTAATGCCAT
CACGAGGGTTCTTATCAGAGACAGGTAGAGGGAGATTTGAGTACAGAAGACAAGATATTCGTGTGATGATGCAGACAGAGACTGGAGTGA
TGCCACCACAAGCCAAGCAATGCCTGGAGCCACCAGGAGCTGGGACAGGCAGGAAGGATTCTCCCTTATACCCCTCAGAGCAATCTTGGC
CCCTCTGACGTCTTGACTTTAGACTTCTGGTCCCCAGAACGGAGAGAGAATAAATCTTTCTTGTTTTAAGGCTCCAACAAATTGGTAGTC
ACTTGTTACAGCAACCACAGGAAATGTATACAGCTTCTGATACTTCTGAAAACCTCACACAGCCAAAGGGTACATCCTTGGTATAGAGGC
TCACTCTTACTCACCAGCCAGGCAAGGAAGGCTCAATCCTTTGGTGTTAGAGAGATAGATGTTGGGTTTTCAAATTTCAACATAGAGAAA
TCAGTCATTTGCAATGCTTTTGAGAAAGTACTGTGTATACCCTACGAGCCTGCACTCCTTATGTGTGAGACTGATGACCATTGGTTGGCT
TATTATCCATTCCACTAAGTGACAAAATCCCACTGACTATTCAAATCCAGGCTCCTGGCATGCCTGTACCTTAGAATCACAACCAGCTGC
AATTCCAGGATGGAGTTCAAACTAATTGTGGGGGCATGTGCTTCTTACATGACTGCTAGATTGTTCCCAGATGGGGAAGGTTGCCCTGAT

>14713_14713_3_CD99-DHRSX_CD99_chrY_2559468_ENST00000381187_DHRSX_chrY_2159644_ENST00000334651_length(amino acids)=270AA_BP=34
MHSGTVPARSGRTMARGAALALLLFGLLGVLVAAPVEFLYCDLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGL
NYLGHFLLTNLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYHLQRLLAAEGSHVTANVVDP
GVVNTDVYKHVFWATRLAKKLLGWLLFKTPDEGAWTSIYAAVTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKSCEMTGVLDVTL

--------------------------------------------------------------
>14713_14713_4_CD99-DHRSX_CD99_chrY_2559468_ENST00000381192_DHRSX_chrY_2159644_ENST00000334651_length(transcript)=2481nt_BP=249nt
GCGCGCGTGGAGGCCGGGGCGGGGCGGGCGCAGCCGGCGCTGAGCTTGCAGGGCCGCTCCCCTCACCCGCCCCCTTCGAGTCCCCGGGCT
TCGCCCCACCCGGCCCGTGGGGGAGTATCTGTCCTGCCGCCTTCGCCCACGCCCTGCACTCCGGGACCGTCCCTGCGCGCTCTGGGCGCA
CCATGGCCCGCGGGGCTGCGCTGGCGCTGCTGCTCTTCGGCCTGCTGGGTGTTCTGGTCGCCGCCCCGGTGGAATTTTTATACTGTGACT
TGGCTTCCATGACTTCCATCCGGCAGTTTGTGCAGAAGTTCAAGATGAAGAAGATTCCTCTCCATGTCCTGATCAACAATGCTGGGGTGA
TGATGGTCCCTCAGAGGAAAACCAGAGATGGATTCGAAGAACATTTCGGCCTGAACTACCTAGGGCACTTCCTGCTGACCAACCTTCTCT
TGGATACGCTGAAAGAGTCTGGGTCCCCTGGCCACAGTGCGAGGGTGGTCACCGTCTCCTCTGCCACCCATTACGTCGCTGAGCTGAACA
TGGATGACCTTCAGAGCAGTGCCTGCTACTCACCCCACGCAGCCTACGCCCAGAGCAAGCTGGCCCTTGTCCTGTTCACCTACCACCTCC
AGCGGCTGCTGGCGGCTGAGGGAAGCCACGTGACCGCCAACGTGGTGGACCCCGGGGTGGTCAACACGGACGTCTACAAGCACGTGTTCT
GGGCCACCCGTCTGGCGAAGAAGCTTCTCGGCTGGTTGCTTTTCAAGACCCCCGATGAAGGAGCGTGGACTTCCATCTACGCAGCAGTCA
CCCCAGAGCTGGAAGGAGTTGGTGGCCATTACCTATACAACGAGAAAGAGACCAAGTCCCTCCACGTCACCTACAACCAGAAACTGCAGC
AGCAGCTGTGGTCTAAGAGTTGTGAGATGACTGGGGTCCTTGATGTGACCCTGTGATATCCTGTCTCAGGATAGCTGCTGCCCCAAGAAA
CACATTGCACCTGCCAATAGCTTGTGGGTCTGTGAAGACTGCGGTGTTTGAGTTTCTCACACCCACCTGCCCACAGGGCTCTGTCCTCTA
GTTTTGAGACAGCTGCCTCAACCTCTGCAGAACTTCAAGAAGCCAAATAAACATTTTGGAGGATAATCACCCCAAGTGGTCTTCAACCAT
AAACTTTGTGATTCCAAAGTGCCCAGTTGTCACAGGTGCCATAAATAATTACATTTTCCAACATAAATGTGCCATTTTCCTTGCCGCGTT
AATACAACTGAGTACAAAAGTTCCAAGAGAGATGCTCTCTTTTCAGGGGCTGCAATGTCCTCTCTGAGACCTAGTGGTGGATGAGGTCTC
CTGTTTGATTTTGTTCCTGCACTCACTCATTTTTCCAGAGACCCAGCTGTGATTCACAGGTGTCAGACATGGGGAGGTGTGAGCCTTGCT
TGCTACAGCCTGTAGGATGAGTTTGACGTGGCCAGCAGCACCATCTGGTCAACCTCATTCCAGAATGGCACAGTCACAAGTGAAGCATGC
CACTGTCAAATCCGAGAATGTAAACCGCTGAACAGCTATGGATCAAATGGTAGCCCTCAAAAGATATGTTCATGCCCTAACCCTCAGAAC
CTATAAATATTACTTTATTTGGAAAAGAATCTTTGCAGATAGAATTAAGAATTTTGAGATGGGTCATTATGGATCATCCCAGTGAACCTA
ATGCCATCACGAGGGTTCTTATCAGAGACAGGTAGAGGGAGATTTGAGTACAGAAGACAAGATATTCGTGTGATGATGCAGACAGAGACT
GGAGTGATGCCACCACAAGCCAAGCAATGCCTGGAGCCACCAGGAGCTGGGACAGGCAGGAAGGATTCTCCCTTATACCCCTCAGAGCAA
TCTTGGCCCCTCTGACGTCTTGACTTTAGACTTCTGGTCCCCAGAACGGAGAGAGAATAAATCTTTCTTGTTTTAAGGCTCCAACAAATT
GGTAGTCACTTGTTACAGCAACCACAGGAAATGTATACAGCTTCTGATACTTCTGAAAACCTCACACAGCCAAAGGGTACATCCTTGGTA
TAGAGGCTCACTCTTACTCACCAGCCAGGCAAGGAAGGCTCAATCCTTTGGTGTTAGAGAGATAGATGTTGGGTTTTCAAATTTCAACAT
AGAGAAATCAGTCATTTGCAATGCTTTTGAGAAAGTACTGTGTATACCCTACGAGCCTGCACTCCTTATGTGTGAGACTGATGACCATTG
GTTGGCTTATTATCCATTCCACTAAGTGACAAAATCCCACTGACTATTCAAATCCAGGCTCCTGGCATGCCTGTACCTTAGAATCACAAC
CAGCTGCAATTCCAGGATGGAGTTCAAACTAATTGTGGGGGCATGTGCTTCTTACATGACTGCTAGATTGTTCCCAGATGGGGAAGGTTG

>14713_14713_4_CD99-DHRSX_CD99_chrY_2559468_ENST00000381192_DHRSX_chrY_2159644_ENST00000334651_length(amino acids)=270AA_BP=34
MHSGTVPARSGRTMARGAALALLLFGLLGVLVAAPVEFLYCDLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGL
NYLGHFLLTNLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYHLQRLLAAEGSHVTANVVDP
GVVNTDVYKHVFWATRLAKKLLGWLLFKTPDEGAWTSIYAAVTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKSCEMTGVLDVTL

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Fusion Gene PPI Analysis for CD99-DHRSX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CD99-DHRSX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CD99-DHRSX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD99C0206637Mesenchymal Chondrosarcoma1CTD_human