Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ASAH1-WWOX (FusionGDB2 ID:HG427TG51741)

Fusion Gene Summary for ASAH1-WWOX

check button Fusion gene summary
Fusion gene informationFusion gene name: ASAH1-WWOX
Fusion gene ID: hg427tg51741
HgeneTgene
Gene symbol

ASAH1

WWOX

Gene ID

427

51741

Gene nameN-acylsphingosine amidohydrolase 1WW domain containing oxidoreductase
SynonymsAC|ACDase|ASAH|PHP|PHP32|SMAPMED16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1
Cytomap('ASAH1')('WWOX')

8p22

16q23.1-q23.2

Type of geneprotein-codingprotein-coding
Descriptionacid ceramidaseN-acylethanolamine hydrolase ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 1acid CDaseacylsphingosine deacylaseputative 32 kDa heart proteinWW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262097, ENST00000381733, 
ENST00000417108, ENST00000520781, 
ENST00000314146, ENST00000520051, 
Fusion gene scores* DoF score15 X 16 X 7=168030 X 23 X 10=6900
# samples 1636
** MAII scorelog2(16/1680*10)=-3.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(36/6900*10)=-4.26052755022322
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASAH1 [Title/Abstract] AND WWOX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASAH1(17927301)-WWOX(79245505), # samples:1
Anticipated loss of major functional domain due to fusion event.ASAH1-WWOX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASAH1-WWOX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASAH1-WWOX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ASAH1-WWOX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ASAH1-WWOX seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ASAH1-WWOX seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ASAH1-WWOX seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ASAH1-WWOX seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASAH1

GO:0046512

sphingosine biosynthetic process

12815059

HgeneASAH1

GO:0046513

ceramide biosynthetic process

12764132|12815059

HgeneASAH1

GO:0046514

ceramide catabolic process

12815059

TgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

TgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691


check buttonFusion gene breakpoints across ASAH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across WWOX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-6545-01AASAH1chr8

17927301

-WWOXchr16

79245505

+


Top

Fusion Gene ORF analysis for ASAH1-WWOX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262097ENST00000355860ASAH1chr8

17927301

-WWOXchr16

79245505

+
5CDS-intronENST00000262097ENST00000408984ASAH1chr8

17927301

-WWOXchr16

79245505

+
5CDS-intronENST00000262097ENST00000565791ASAH1chr8

17927301

-WWOXchr16

79245505

+
5CDS-intronENST00000262097ENST00000569818ASAH1chr8

17927301

-WWOXchr16

79245505

+
5CDS-intronENST00000381733ENST00000355860ASAH1chr8

17927301

-WWOXchr16

79245505

+
5CDS-intronENST00000381733ENST00000408984ASAH1chr8

17927301

-WWOXchr16

79245505

+
5CDS-intronENST00000381733ENST00000565791ASAH1chr8

17927301

-WWOXchr16

79245505

+
5CDS-intronENST00000381733ENST00000569818ASAH1chr8

17927301

-WWOXchr16

79245505

+
5CDS-intronENST00000417108ENST00000355860ASAH1chr8

17927301

-WWOXchr16

79245505

+
5CDS-intronENST00000417108ENST00000408984ASAH1chr8

17927301

-WWOXchr16

79245505

+
5CDS-intronENST00000417108ENST00000565791ASAH1chr8

17927301

-WWOXchr16

79245505

+
5CDS-intronENST00000417108ENST00000569818ASAH1chr8

17927301

-WWOXchr16

79245505

+
5CDS-intronENST00000520781ENST00000355860ASAH1chr8

17927301

-WWOXchr16

79245505

+
5CDS-intronENST00000520781ENST00000408984ASAH1chr8

17927301

-WWOXchr16

79245505

+
5CDS-intronENST00000520781ENST00000565791ASAH1chr8

17927301

-WWOXchr16

79245505

+
5CDS-intronENST00000520781ENST00000569818ASAH1chr8

17927301

-WWOXchr16

79245505

+
Frame-shiftENST00000262097ENST00000402655ASAH1chr8

17927301

-WWOXchr16

79245505

+
Frame-shiftENST00000262097ENST00000406884ASAH1chr8

17927301

-WWOXchr16

79245505

+
Frame-shiftENST00000262097ENST00000566780ASAH1chr8

17927301

-WWOXchr16

79245505

+
Frame-shiftENST00000381733ENST00000402655ASAH1chr8

17927301

-WWOXchr16

79245505

+
Frame-shiftENST00000381733ENST00000406884ASAH1chr8

17927301

-WWOXchr16

79245505

+
Frame-shiftENST00000381733ENST00000566780ASAH1chr8

17927301

-WWOXchr16

79245505

+
Frame-shiftENST00000417108ENST00000402655ASAH1chr8

17927301

-WWOXchr16

79245505

+
Frame-shiftENST00000417108ENST00000406884ASAH1chr8

17927301

-WWOXchr16

79245505

+
Frame-shiftENST00000417108ENST00000566780ASAH1chr8

17927301

-WWOXchr16

79245505

+
Frame-shiftENST00000520781ENST00000402655ASAH1chr8

17927301

-WWOXchr16

79245505

+
Frame-shiftENST00000520781ENST00000406884ASAH1chr8

17927301

-WWOXchr16

79245505

+
Frame-shiftENST00000520781ENST00000566780ASAH1chr8

17927301

-WWOXchr16

79245505

+
In-frameENST00000262097ENST00000539474ASAH1chr8

17927301

-WWOXchr16

79245505

+
In-frameENST00000381733ENST00000539474ASAH1chr8

17927301

-WWOXchr16

79245505

+
In-frameENST00000417108ENST00000539474ASAH1chr8

17927301

-WWOXchr16

79245505

+
In-frameENST00000520781ENST00000539474ASAH1chr8

17927301

-WWOXchr16

79245505

+
intron-3CDSENST00000314146ENST00000402655ASAH1chr8

17927301

-WWOXchr16

79245505

+
intron-3CDSENST00000314146ENST00000406884ASAH1chr8

17927301

-WWOXchr16

79245505

+
intron-3CDSENST00000314146ENST00000539474ASAH1chr8

17927301

-WWOXchr16

79245505

+
intron-3CDSENST00000314146ENST00000566780ASAH1chr8

17927301

-WWOXchr16

79245505

+
intron-3CDSENST00000520051ENST00000402655ASAH1chr8

17927301

-WWOXchr16

79245505

+
intron-3CDSENST00000520051ENST00000406884ASAH1chr8

17927301

-WWOXchr16

79245505

+
intron-3CDSENST00000520051ENST00000539474ASAH1chr8

17927301

-WWOXchr16

79245505

+
intron-3CDSENST00000520051ENST00000566780ASAH1chr8

17927301

-WWOXchr16

79245505

+
intron-intronENST00000314146ENST00000355860ASAH1chr8

17927301

-WWOXchr16

79245505

+
intron-intronENST00000314146ENST00000408984ASAH1chr8

17927301

-WWOXchr16

79245505

+
intron-intronENST00000314146ENST00000565791ASAH1chr8

17927301

-WWOXchr16

79245505

+
intron-intronENST00000314146ENST00000569818ASAH1chr8

17927301

-WWOXchr16

79245505

+
intron-intronENST00000520051ENST00000355860ASAH1chr8

17927301

-WWOXchr16

79245505

+
intron-intronENST00000520051ENST00000408984ASAH1chr8

17927301

-WWOXchr16

79245505

+
intron-intronENST00000520051ENST00000565791ASAH1chr8

17927301

-WWOXchr16

79245505

+
intron-intronENST00000520051ENST00000569818ASAH1chr8

17927301

-WWOXchr16

79245505

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000262097ASAH1chr817927301-ENST00000539474WWOXchr1679245505+167561515803262
ENST00000381733ASAH1chr817927301-ENST00000539474WWOXchr1679245505+15785185706233
ENST00000417108ASAH1chr817927301-ENST00000539474WWOXchr1679245505+139933921527168
ENST00000520781ASAH1chr817927301-ENST00000539474WWOXchr1679245505+167561515803262

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262097ENST00000539474ASAH1chr817927301-WWOXchr1679245505+0.0250162260.97498375
ENST00000381733ENST00000539474ASAH1chr817927301-WWOXchr1679245505+0.112233930.88776606
ENST00000417108ENST00000539474ASAH1chr817927301-WWOXchr1679245505+0.0199213550.9800787
ENST00000520781ENST00000539474ASAH1chr817927301-WWOXchr1679245505+0.0250162260.97498375

Top

Fusion Genomic Features for ASAH1-WWOX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ASAH1chr817927300-WWOXchr1679245504+1.33E-060.9999987
ASAH1chr817927300-WWOXchr1679245504+1.33E-060.9999987

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ASAH1-WWOX


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:17927301/chr16:79245505)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWWOXchr8:17927301chr16:79245505ENST000003558600616_490190.0DomainWW 1
TgeneWWOXchr8:17927301chr16:79245505ENST000003558600657_900190.0DomainWW 2
TgeneWWOXchr8:17927301chr16:79245505ENST0000040898401016_490311.6666666666667DomainWW 1
TgeneWWOXchr8:17927301chr16:79245505ENST0000040898401057_900311.6666666666667DomainWW 2
TgeneWWOXchr8:17927301chr16:79245505ENST000005698180116_49037.0DomainWW 1
TgeneWWOXchr8:17927301chr16:79245505ENST000005698180157_90037.0DomainWW 2
TgeneWWOXchr8:17927301chr16:79245505ENST000003558600650_550190.0MotifNuclear localization signal
TgeneWWOXchr8:17927301chr16:79245505ENST0000040898401050_550311.6666666666667MotifNuclear localization signal
TgeneWWOXchr8:17927301chr16:79245505ENST000005698180150_55037.0MotifNuclear localization signal
TgeneWWOXchr8:17927301chr16:79245505ENST0000035586006131_1370190.0Nucleotide bindingNADP
TgeneWWOXchr8:17927301chr16:79245505ENST00000408984010131_1370311.6666666666667Nucleotide bindingNADP
TgeneWWOXchr8:17927301chr16:79245505ENST0000056981801131_137037.0Nucleotide bindingNADP
TgeneWWOXchr8:17927301chr16:79245505ENST0000035586006209_2730190.0RegionMediates targeting to the mitochondria
TgeneWWOXchr8:17927301chr16:79245505ENST0000040265535209_273136312.0RegionMediates targeting to the mitochondria
TgeneWWOXchr8:17927301chr16:79245505ENST0000040688446209_273172235.0RegionMediates targeting to the mitochondria
TgeneWWOXchr8:17927301chr16:79245505ENST00000408984010209_2730311.6666666666667RegionMediates targeting to the mitochondria
TgeneWWOXchr8:17927301chr16:79245505ENST0000056981801209_273037.0RegionMediates targeting to the mitochondria

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWWOXchr8:17927301chr16:79245505ENST000004026553516_49136312.0DomainWW 1
TgeneWWOXchr8:17927301chr16:79245505ENST000004026553557_90136312.0DomainWW 2
TgeneWWOXchr8:17927301chr16:79245505ENST000004068844616_49172235.0DomainWW 1
TgeneWWOXchr8:17927301chr16:79245505ENST000004068844657_90172235.0DomainWW 2
TgeneWWOXchr8:17927301chr16:79245505ENST000005667807916_49352415.0DomainWW 1
TgeneWWOXchr8:17927301chr16:79245505ENST000005667807957_90352415.0DomainWW 2
TgeneWWOXchr8:17927301chr16:79245505ENST000004026553550_55136312.0MotifNuclear localization signal
TgeneWWOXchr8:17927301chr16:79245505ENST000004068844650_55172235.0MotifNuclear localization signal
TgeneWWOXchr8:17927301chr16:79245505ENST000005667807950_55352415.0MotifNuclear localization signal
TgeneWWOXchr8:17927301chr16:79245505ENST0000040265535131_137136312.0Nucleotide bindingNADP
TgeneWWOXchr8:17927301chr16:79245505ENST0000040688446131_137172235.0Nucleotide bindingNADP
TgeneWWOXchr8:17927301chr16:79245505ENST0000056678079131_137352415.0Nucleotide bindingNADP
TgeneWWOXchr8:17927301chr16:79245505ENST0000056678079209_273352415.0RegionMediates targeting to the mitochondria


Top

Fusion Gene Sequence for ASAH1-WWOX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6947_6947_1_ASAH1-WWOX_ASAH1_chr8_17927301_ENST00000262097_WWOX_chr16_79245505_ENST00000539474_length(transcript)=1675nt_BP=615nt
GGCTCGGTCCGACTATTGCCCGCGGTGGGGGAGGGGGATGGATCACGCCACGCGCCAAAGGCGATCGCGACTCTCCTTCTGCAGGTAGCC
TGGAAGGCTCTCTCTCTTTCTCTACGCCACCCTTTTCGTGGCACTGAAAAGCCCCGTCCTCTCCTCCCAGTCCCGCCTCCTCCGAGCGTT
CCCCCTACTGCCTGGAATGGTGCGGTCCCAGGTCGCGGGTCACGCGGCGGAGGGGGCGTGGCCTGCCCCCGGCCCAGCCGGCTCTTCTTT
GCCTCTGCTGGAGTCCGGGGAGTGGCGTTGGCTGCTAGAGCGATGCCGGGCCGGAGTTGCGTCGCCTTAGTCCTCCTGGCTGCCGCCGTC
AGCTGTGCCGTCGCGCAGCACGCGCCGCCGTGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACGTACAGAGGTGCA
GTTCCATGGTACACCATAAATCTTGACTTACCACCCTACAAAAGATGGCATGAATTGATGCTTGACAAGGCACCAGTGCTAAAGGTTATA
GTGAATTCTCTGAAGAATATGATAAATACATTCGTGCCAAGTGGAAAAATTATGCAGGTGGTGGATGAAAAATTGCAACAGGGAGCTGCC
ACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAA
GCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAG
CTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACAC
AGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAG
TATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGT
TCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACC
ACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAG
ATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGA
TGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAA
ATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAG
GATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAA

>6947_6947_1_ASAH1-WWOX_ASAH1_chr8_17927301_ENST00000262097_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=262AA_BP=200
MPAVGEGDGSRHAPKAIATLLLQVAWKALSLSLRHPFRGTEKPRPLLPVPPPPSVPPTAWNGAVPGRGSRGGGGVACPRPSRLFFASAGV
RGVALAARAMPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLK

--------------------------------------------------------------
>6947_6947_2_ASAH1-WWOX_ASAH1_chr8_17927301_ENST00000381733_WWOX_chr16_79245505_ENST00000539474_length(transcript)=1578nt_BP=518nt
GGACTTTGAAATCCAACCCGGTCACCTACCCGCGCGACTGTGTCCACGGATGGCACGAAAGCCAAGCGAGTCCCCCTGCCGAGCTACTCG
CGTCCGCCTCCTCCCAAGCTGAGCTCTGCTCCGCCCACCTGAGTCCTTCGCCAGTTAGGAGGAAACACAGCCGCTTAATGAACTGCTGCA
TCGGGCTGGGAGAGAAAGCTCGCGGGTCCCACCGGGCCTCCTACCCAAGTCTCAGCGCGCTTTTCACCGAGGCCTCAATTCTGGGATTTG
GCAGCTTTGCTGTGAAAGCCCAATGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACGTACAGAGGTGCAGTTCCAT
GGTACACCATAAATCTTGACTTACCACCCTACAAAAGATGGCATGAATTGATGCTTGACAAGGCACCAGTGCTAAAGGTTATAGTGAATT
CTCTGAAGAATATGATAAATACATTCGTGCCAAGTGGAAAAATTATGCAGGTGGTGGATGAAAAATTGCAACAGGGAGCTGCCACCACCG
TGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGA
GCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAG
CGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCG
CAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACT
TTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTAT
CTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCA
CCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTG
TTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGT
GACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTT
AGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTT
TGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCT

>6947_6947_2_ASAH1-WWOX_ASAH1_chr8_17927301_ENST00000381733_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=233AA_BP=171
MKSNPVTYPRDCVHGWHESQASPPAELLASASSQAELCSAHLSPSPVRRKHSRLMNCCIGLGEKARGSHRASYPSLSALFTEASILGFGS
FAVKAQWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLQQGAATTVY

--------------------------------------------------------------
>6947_6947_3_ASAH1-WWOX_ASAH1_chr8_17927301_ENST00000417108_WWOX_chr16_79245505_ENST00000539474_length(transcript)=1399nt_BP=339nt
GCTGGAGTCCGGGGAGTGGCGTTGGCTGCTAGAGCGATGCCGGGCCGGAGTTGCGTCGCCTTAGTCCTCCTGGCTGCCGCCGTCAGCTGT
GCCGTCGCGCAGCACGCGCCGCCGTGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACGTACAGAGGTGCAGTTCCA
TGGTACACCATAAATCTTGACTTACCACCCTACAAAAGATGGCATGAATTGATGCTTGACAAGGCACCAGTGCTAAAGGTTATAGTGAAT
TCTCTGAAGAATATGATAAATACATTCGTGCCAAGTGGAAAAATTATGCAGGTGGTGGATGAAAAATTGCAACAGGGAGCTGCCACCACC
GTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAG
AGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGA
GCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCC
GCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCAC
TTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTA
TCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCC
ACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATT
GTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAG
TGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTT
TAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATT
TTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCC

>6947_6947_3_ASAH1-WWOX_ASAH1_chr8_17927301_ENST00000417108_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=168AA_BP=106
MAARAMPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMIN

--------------------------------------------------------------
>6947_6947_4_ASAH1-WWOX_ASAH1_chr8_17927301_ENST00000520781_WWOX_chr16_79245505_ENST00000539474_length(transcript)=1675nt_BP=615nt
GGCTCGGTCCGACTATTGCCCGCGGTGGGGGAGGGGGATGGATCACGCCACGCGCCAAAGGCGATCGCGACTCTCCTTCTGCAGGTAGCC
TGGAAGGCTCTCTCTCTTTCTCTACGCCACCCTTTTCGTGGCACTGAAAAGCCCCGTCCTCTCCTCCCAGTCCCGCCTCCTCCGAGCGTT
CCCCCTACTGCCTGGAATGGTGCGGTCCCAGGTCGCGGGTCACGCGGCGGAGGGGGCGTGGCCTGCCCCCGGCCCAGCCGGCTCTTCTTT
GCCTCTGCTGGAGTCCGGGGAGTGGCGTTGGCTGCTAGAGCGATGCCGGGCCGGAGTTGCGTCGCCTTAGTCCTCCTGGCTGCCGCCGTC
AGCTGTGCCGTCGCGCAGCACGCGCCGCCGTGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACGTACAGAGGTGCA
GTTCCATGGTACACCATAAATCTTGACTTACCACCCTACAAAAGATGGCATGAATTGATGCTTGACAAGGCACCAGTGCTAAAGGTTATA
GTGAATTCTCTGAAGAATATGATAAATACATTCGTGCCAAGTGGAAAAATTATGCAGGTGGTGGATGAAAAATTGCAACAGGGAGCTGCC
ACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAA
GCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAG
CTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACAC
AGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAG
TATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGT
TCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACC
ACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAG
ATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGA
TGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAA
ATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAG
GATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAA

>6947_6947_4_ASAH1-WWOX_ASAH1_chr8_17927301_ENST00000520781_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=262AA_BP=200
MPAVGEGDGSRHAPKAIATLLLQVAWKALSLSLRHPFRGTEKPRPLLPVPPPPSVPPTAWNGAVPGRGSRGGGGVACPRPSRLFFASAGV
RGVALAARAMPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ASAH1-WWOX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneWWOXchr8:17927301chr16:79245505ENST0000035586006125_4140190.0MAPT
TgeneWWOXchr8:17927301chr16:79245505ENST00000408984010125_4140311.6666666666667MAPT
TgeneWWOXchr8:17927301chr16:79245505ENST0000056981801125_414037.0MAPT


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneWWOXchr8:17927301chr16:79245505ENST0000040265535125_414136.33333333333334312.0MAPT
TgeneWWOXchr8:17927301chr16:79245505ENST0000040688446125_414172.0235.0MAPT
TgeneWWOXchr8:17927301chr16:79245505ENST0000056678079125_414352.0415.0MAPT


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ASAH1-WWOX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ASAH1-WWOX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASAH1C0268255Farber Lipogranulomatosis15CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneASAH1C1834569Jankovic Rivera syndrome4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneASAH1C0004238Atrial Fibrillation2CTD_human
HgeneASAH1C0023794Lipoidosis2CTD_human
HgeneASAH1C0235480Paroxysmal atrial fibrillation2CTD_human
HgeneASAH1C2585653Persistent atrial fibrillation2CTD_human
HgeneASAH1C3468561familial atrial fibrillation2CTD_human
HgeneASAH1C0020305Hydrops Fetalis1GENOMICS_ENGLAND
HgeneASAH1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneASAH1C0036341Schizophrenia1PSYGENET
HgeneASAH1C0221765Chronic schizophrenia1PSYGENET
HgeneASAH1C0455988Hydrops Fetalis, Non-Immune1GENOMICS_ENGLAND
HgeneASAH1C3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneC0279626Squamous cell carcinoma of esophagus3CTD_human;ORPHANET
TgeneC3280452SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 122GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC4015519EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 282CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0002395Alzheimer's Disease1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0007137Squamous cell carcinoma1CTD_human
TgeneC0011265Presenile dementia1CTD_human
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC0042076Urologic Neoplasms1CTD_human
TgeneC0087031Juvenile-Onset Still Disease1CTD_human
TgeneC0276496Familial Alzheimer Disease (FAD)1CTD_human
TgeneC0494463Alzheimer Disease, Late Onset1CTD_human
TgeneC0546126Acute Confusional Senile Dementia1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0750900Alzheimer's Disease, Focal Onset1CTD_human
TgeneC0750901Alzheimer Disease, Early Onset1CTD_human
TgeneC0751571Cancer of Urinary Tract1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC3495559Juvenile arthritis1CTD_human
TgeneC3714758Juvenile psoriatic arthritis1CTD_human
TgeneC451074446,XY partial gonadal dysgenesis1ORPHANET
TgeneC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human