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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AFF1-UBR5 (FusionGDB2 ID:HG4299TG51366)

Fusion Gene Summary for AFF1-UBR5

check button Fusion gene summary
Fusion gene informationFusion gene name: AFF1-UBR5
Fusion gene ID: hg4299tg51366
HgeneTgene
Gene symbol

AFF1

UBR5

Gene ID

4299

51366

Gene nameAF4/FMR2 family member 1ubiquitin protein ligase E3 component n-recognin 5
SynonymsAF4|MLLT2|PBM1DD5|EDD|EDD1|HYD
Cytomap('AFF1')('UBR5')

4q21.3-q22.1

8q22.3

Type of geneprotein-codingprotein-coding
DescriptionAF4/FMR2 family member 1ALL1-fused gene from chromosome 4 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2pre-B-cell monocytic leukemia partner 1proto-oncogene AF4E3 ubiquitin-protein ligase UBR5E3 identified by differential displayE3 ubiquitin-protein ligase, HECT domain-containing 1HECT-type E3 ubiquitin transferase UBR5hyperplastic discs protein homologprogestin-induced protein
Modification date2020031320200315
UniProtAcc

P51825

.
Ensembl transtripts involved in fusion geneENST00000307808, ENST00000544085, 
ENST00000395146, ENST00000511996, 
Fusion gene scores* DoF score27 X 51 X 13=1790114 X 17 X 10=2380
# samples 6819
** MAII scorelog2(68/17901*10)=-4.71836162613835
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2380*10)=-3.64689024986436
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AFF1 [Title/Abstract] AND UBR5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAFF1(87928576)-UBR5(103373854), # samples:1
Anticipated loss of major functional domain due to fusion event.AFF1-UBR5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF1-UBR5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF1-UBR5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF1-UBR5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBR5

GO:0000209

protein polyubiquitination

21118991|28689657

TgeneUBR5

GO:0006974

cellular response to DNA damage stimulus

12011095

TgeneUBR5

GO:0010628

positive regulation of gene expression

18076571

TgeneUBR5

GO:0050847

progesterone receptor signaling pathway

12011095

TgeneUBR5

GO:0070936

protein K48-linked ubiquitination

28689657


check buttonFusion gene breakpoints across AFF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across UBR5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-1743AFF1chr4

87928576

+UBR5chr8

103373854

-


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Fusion Gene ORF analysis for AFF1-UBR5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000307808ENST00000518205AFF1chr4

87928576

+UBR5chr8

103373854

-
5CDS-intronENST00000307808ENST00000519528AFF1chr4

87928576

+UBR5chr8

103373854

-
5CDS-intronENST00000307808ENST00000521922AFF1chr4

87928576

+UBR5chr8

103373854

-
5UTR-3CDSENST00000544085ENST00000220959AFF1chr4

87928576

+UBR5chr8

103373854

-
5UTR-3CDSENST00000544085ENST00000520539AFF1chr4

87928576

+UBR5chr8

103373854

-
5UTR-intronENST00000544085ENST00000518205AFF1chr4

87928576

+UBR5chr8

103373854

-
5UTR-intronENST00000544085ENST00000519528AFF1chr4

87928576

+UBR5chr8

103373854

-
5UTR-intronENST00000544085ENST00000521922AFF1chr4

87928576

+UBR5chr8

103373854

-
In-frameENST00000307808ENST00000220959AFF1chr4

87928576

+UBR5chr8

103373854

-
In-frameENST00000307808ENST00000520539AFF1chr4

87928576

+UBR5chr8

103373854

-
intron-3CDSENST00000395146ENST00000220959AFF1chr4

87928576

+UBR5chr8

103373854

-
intron-3CDSENST00000395146ENST00000520539AFF1chr4

87928576

+UBR5chr8

103373854

-
intron-3CDSENST00000511996ENST00000220959AFF1chr4

87928576

+UBR5chr8

103373854

-
intron-3CDSENST00000511996ENST00000520539AFF1chr4

87928576

+UBR5chr8

103373854

-
intron-intronENST00000395146ENST00000518205AFF1chr4

87928576

+UBR5chr8

103373854

-
intron-intronENST00000395146ENST00000519528AFF1chr4

87928576

+UBR5chr8

103373854

-
intron-intronENST00000395146ENST00000521922AFF1chr4

87928576

+UBR5chr8

103373854

-
intron-intronENST00000511996ENST00000518205AFF1chr4

87928576

+UBR5chr8

103373854

-
intron-intronENST00000511996ENST00000519528AFF1chr4

87928576

+UBR5chr8

103373854

-
intron-intronENST00000511996ENST00000521922AFF1chr4

87928576

+UBR5chr8

103373854

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000307808AFF1chr487928576+ENST00000520539UBR5chr8103373854-1006543742087742784
ENST00000307808AFF1chr487928576+ENST00000220959UBR5chr8103373854-933843742087712783

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000307808ENST00000520539AFF1chr487928576+UBR5chr8103373854-0.0010911240.9989089
ENST00000307808ENST00000220959AFF1chr487928576+UBR5chr8103373854-0.0018443130.99815565

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Fusion Genomic Features for AFF1-UBR5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AFF1-UBR5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:87928576/chr8:103373854)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AFF1

P51825

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUBR5chr4:87928576chr8:103373854ENST000005205390591528_1537202800.0Compositional biasNote=Poly-Ser
TgeneUBR5chr4:87928576chr8:103373854ENST000005205390591671_1681202800.0Compositional biasNote=Poly-Ser
TgeneUBR5chr4:87928576chr8:103373854ENST000005205390591762_1768202800.0Compositional biasNote=Poly-Ala
TgeneUBR5chr4:87928576chr8:103373854ENST000005205390591986_1997202800.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneUBR5chr4:87928576chr8:103373854ENST000005205390592036_2059202800.0Compositional biasNote=Pro-rich
TgeneUBR5chr4:87928576chr8:103373854ENST000005205390592329_2348202800.0Compositional biasNote=Arg/Glu-rich (mixed charge)
TgeneUBR5chr4:87928576chr8:103373854ENST000005205390592357_2366202800.0Compositional biasNote=Arg/Asp-rich (mixed charge)
TgeneUBR5chr4:87928576chr8:103373854ENST000005205390592489_2500202800.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneUBR5chr4:87928576chr8:103373854ENST000005205390592737_2757202800.0Compositional biasNote=Pro-rich
TgeneUBR5chr4:87928576chr8:103373854ENST00000520539059940_945202800.0Compositional biasNote=Poly-Glu
TgeneUBR5chr4:87928576chr8:103373854ENST00000520539059980_985202800.0Compositional biasNote=Poly-Ser
TgeneUBR5chr4:87928576chr8:103373854ENST000005205390592377_2454202800.0DomainPABC
TgeneUBR5chr4:87928576chr8:103373854ENST000005205390592462_2799202800.0DomainHECT
TgeneUBR5chr4:87928576chr8:103373854ENST000005205390591177_1245202800.0Zinc fingerUBR-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAFF1chr4:87928576chr8:103373854ENST00000307808+120483_49251211.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:87928576chr8:103373854ENST00000307808+120835_84351211.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:87928576chr8:103373854ENST00000307808+120866_86951211.0Compositional biasNote=Poly-Pro
HgeneAFF1chr4:87928576chr8:103373854ENST00000307808+120871_87451211.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:87928576chr8:103373854ENST00000395146+121483_49201219.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:87928576chr8:103373854ENST00000395146+121835_84301219.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:87928576chr8:103373854ENST00000395146+121866_86901219.0Compositional biasNote=Poly-Pro
HgeneAFF1chr4:87928576chr8:103373854ENST00000395146+121871_87401219.0Compositional biasNote=Poly-Ser


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Fusion Gene Sequence for AFF1-UBR5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2670_2670_1_AFF1-UBR5_AFF1_chr4_87928576_ENST00000307808_UBR5_chr8_103373854_ENST00000220959_length(transcript)=9338nt_BP=437nt
GGCAATTTCTTTTCCTTTCTAACTGTGGCCCGCGTTGTGCTGTTGCTGGGCAGGCGTTGGGCGCCGGCGGTCTTCGAGCGTGGGGGCCCG
CTGGCTTTCCCTTCTCAGAAACTGCGCCGGGGGCGCTCGCTTGCCCCGGATTCGGACGCGGCGCTCCCCGGGCTCGTCTGAAGTGCAGAT
CGCCGCAGAGGCCCCAGTGCCCGGATGTCCATCAGGATTAGCGCGAGCCAATACGGGCCGAGCCCGGGGCTGCGCCGAGGACGCCCGGGG
CTCGAGAGCAGGTAGTCCCGTAACATCGGGGCGCCGCGCCGGGACGCGTCCCCGCCCGGCTCCGCCAAATGGTGAGCGCGGCGCTGGCAG
CAGGGCCCGCGGGGTGAAGGCGCTCATGGACGGAAGACCCCTGGCTCTATAAGCTGAATTATGGCAGCCCAGTCAAGGTTACGAGAAGTT
TCTGAGAAGCTGAACAAATATAATTTAAACAGCCACCCCCCTTTGAATGTATTGGAACAGGCTACTATTAAACAGTGTGTGGTGGGACCA
AATCATGCTGCCTTTCTTCTTGAGGATGGTAGAGTTTGCAGGATTGGTTTTTCAGTACAGCCAGACAGATTGGAATTGGGTAAACCTGAT
AATAATGATGGGTCAAAGTTGAACAGCAACTCGGGGGCAGGGAGGACGTCAAGGCCTGGTAGGACAAGCGACTCTCCATGGTTTCTCTCA
GGTTCTGAGACTCTAGGCAGGCTGGCAGGCAACACCTTAGGAAGCCGCTGGAGTTCTGGAGTGGGTGGAAGTGGTGGAGGATCCTCTGGT
AGGTCATCAGCTGGAGCTCGAGATTCCCGCCGGCAGACTCGAGTTATTCGGACAGGACGGGATCGAGGGTCTGGGCTTTTGGGCAGTCAG
CCCCAGCCAGTTATTCCAGCATCTGTCATTCCAGAGGAGCTGATTTCACAGGCCCAAGTTGTTTTACAAGGCAAATCCAGAAGTGTCATT
ATTCGAGAACTTCAGAGAACAAATCTTGATGTGAACCTTGCTGTAAATAATTTACTTAGCCGGGATGATGAAGATGGAGATGATGGGGAT
GATACAGCCAGCGAATCTTATTTGCCTGGAGAGGATCTTATGTCTCTCCTTGATGCCGACATTCATTCTGCCCACCCAAGTGTCATTATT
GATGCAGATGCCATGTTTTCTGAAGACATTAGCTATTTTGGTTACCCTTCTTTTCGTCGTTCATCACTTTCCAGGCTAGGCTCATCTCGA
GTTCTCCTTCTTCCCTTAGAGAGAGACTCTGAGCTGTTGCGTGAACGTGAATCCGTTTTACGTTTACGTGAACGAAGGTGGCTTGATGGA
GCCTCATTTGATAATGAAAGGGGTTCTACCAGCAAGGAAGGAGAGCCAAACTTGGATAAGAAGAATACACCTGTTCAAAGTCCAGTATCT
CTAGGAGAAGATTTGCAGTGGTGGCCTGATAAGGATGGAACAAAATTCATCTGTATTGGGGCTCTGTATTCTGAACTTCTGGCTGTCAGC
AGTAAAGGAGAACTTTATCAGTGGAAATGGAGTGAATCTGAGCCTTACAGAAATGCCCAGAATCCTTCATTACATCATCCACGAGCAACA
TTTTTGGGGTTAACCAATGAAAAGATAGTCCTCCTGTCTGCAAATAGCATAAGAGCAACTGTAGCTACAGAAAATAACAAGGTTGCTACA
TGGGTGGATGAAACTTTAAGTTCTGTGGCTTCTAAATTAGAGCACACTGCTCAGACTTACTCTGAACTTCAAGGAGAGCGGATAGTTTCT
TTACATTGCTGTGCCCTTTACACCTGCGCTCAGCTGGAAAACAGTTTATATTGGTGGGGTGTAGTTCCTTTTAGTCAAAGGAAGAAAATG
TTAGAGAAAGCTAGAGCAAAAAATAAAAAGCCTAAATCCAGTGCTGGTATTTCTTCAATGCCGAACATCACTGTTGGTACCCAGGTATGC
TTGAGAAATAATCCTCTTTATCATGCTGGAGCAGTTGCATTTTCAATTAGTGCTGGGATTCCTAAAGTTGGTGTCTTAATGGAGTCAGTT
TGGAATATGAATGACAGCTGTAGATTTCAACTTAGATCTCCTGAAAGCTTGAAAAACATGGAAAAAGCTAGCAAAACTACTGAAGCTAAG
CCTGAAAGTAAGCAGGAGCCAGTGAAAACAGAAATGGGTCCTCCACCATCTCCAGCATCCACGTGTAGTGATGCATCCTCAATTGCCAGC
AGTGCATCAATGCCATACAAACGACGACGGTCAACCCCTGCACCAAAAGAAGAGGAAAAGGTGAATGAAGAGCAGTGGTCTCTTCGGGAA
GTGGTTTTTGTGGAAGATGTCAAGAATGTTCCTGTTGGCAAGGTGCTAAAAGTAGATGGTGCCTATGTTGCTGTAAAATTTCCAGGAACC
TCCAGTAATACTAACTGTCAGAACAGCTCTGGTCCAGATGCTGACCCTTCTTCTCTCCTGCAGGATTGTAGGTTACTTAGAATTGATGAA
TTGCAGGTTGTCAAAACTGGTGGAACACCGAAGGTTCCCGACTGTTTCCAAAGGACTCCTAAAAAGCTTTGTATACCTGAAAAAACAGAA
ATATTAGCAGTGAATGTAGATTCCAAAGGTGTTCATGCTGTTCTGAAGACTGGAAATTGGGTACGATACTGTATCTTTGATCTTGCTACA
GGAAAAGCAGAACAGGAAAATAATTTTCCTACAAGCAGCATTGCTTTCCTTGGTCAGAATGAGAGGAATGTAGCCATTTTCACTGCTGGA
CAGGAATCTCCCATTATTCTTCGAGATGGAAATGGTACCATCTACCCAATGGCCAAAGATTGCATGGGAGGAATAAGGGATCCCGATTGG
CTGGATCTTCCACCTATTAGTAGTCTTGGAATGGGTGTGCATTCTTTAATAAATCTTCCTGCCAATTCAACAATCAAAAAGAAAGCTGCT
GTTATCATCATGGCTGTAGAGAAACAAACCTTAATGCAACACATTCTGCGCTGTGACTATGAGGCCTGTCGACAATATCTAATGAATCTT
GAGCAAGCGGTTGTTTTAGAGCAGAATCTACAGATGCTGCAGACATTCATCAGCCACAGATGTGATGGAAATCGAAATATTTTGCATGCT
TGTGTATCAGTTTGCTTTCCAACCAGCAATAAAGAAACTAAAGAAGAAGAGGAAGCGGAGCGTTCTGAAAGAAATACATTTGCAGAAAGG
CTTTCTGCTGTTGAGGCCATTGCAAATGCAATATCAGTTGTTTCAAGTAATGGCCCAGGTAATCGGGCTGGATCATCAAGTAGCCGAAGT
TTGAGATTACGGGAAATGATGAGACGTTCGTTGAGAGCAGCTGGTTTGGGTAGACATGAAGCTGGAGCTTCATCCAGTGACCACCAGGAT
CCAGTTTCACCCCCCATAGCTCCCCCTAGTTGGGTTCCTGACCCTCCTGCGATGGATCCTGATGGTGACATTGATTTTATCCTGGCCCCC
GCTGTGGGATCTCTTACCACAGCAGCAACCGGTACTGGTCAAGGACCAAGCACCTCCACTATTCCAGGTCCTTCCACAGAGCCATCTGTA
GTAGAATCCAAGGATCGAAAGGCGAATGCTCATTTTATATTGAAATTGTTATGTGACAGTGTGGTTCTCCAGCCCTATCTACGAGAACTT
CTTTCTGCCAAGGATGCAAGAGGGATGACCCCATTTATGTCAGCTGTAAGTGGCCGAGCTTATCCTGCTGCAATTACCATCTTAGAAACT
GCTCAGAAAATTGCAAAAGCTGAAATATCCTCAAGTGAAAAAGAGGAAGATGTATTCATGGGAATGGTTTGCCCATCAGGTACCAACCCT
GATGACTCTCCTTTATATGTTTTATGTTGTAATGACACTTGCAGTTTTACATGGACTGGAGCAGAGCACATTAACCAGGATATTTTTGAG
TGTCGAACTTGTGGCTTGCTGGAGTCACTGTGTTGTTGTACGGAATGTGCAAGGGTTTGTCATAAAGGTCATGATTGCAAACTCAAACGG
ACATCACCAACAGCCTACTGTGATTGTTGGGAGAAATGTAAATGTAAAACTCTTATTGCTGGACAGAAATCTGCTCGTCTTGATCTACTT
TATCGCCTGCTCACTGCTACTAATCTGGTTACTCTGCCAAACAGCAGGGGAGAGCACCTCTTACTATTCTTAGTACAGACAGTCGCAAGG
CAGACGGTGGAGCATTGTCAATACAGGCCACCTCGAATCAGGGAAGATCGTAACCGAAAAACAGCCAGTCCTGAAGATTCAGATATGCCA
GATCATGATTTAGAGCCTCCAAGATTTGCCCAGCTTGCATTGGAGCGTGTTCTACAGGACTGGAATGCCTTGAAATCTATGATTATGTTT
GGGTCGCAGGAGAATAAAGACCCTCTTAGTGCCAGCAGTAGAATAGGCCATCTTTTGCCAGAAGAGCAAGTATACCTCAATCAGCAAAGT
GGCACAATTCGGCTGGACTGTTTCACTCATTGCCTTATAGTTAAGTGTACAGCAGATATTTTGCTTTTAGATACTCTACTAGGTACACTA
GTGAAAGAACTCCAAAACAAATATACACCTGGACGTAGAGAAGAAGCTATTGCTGTGACAATGAGGTTTCTACGTTCAGTGGCAAGAGTT
TTTGTTATTCTGAGTGTGGAAATGGCTTCATCCAAAAAGAAAAACAACTTTATTCCACAGCCAATTGGAAAATGCAAGCGTGTATTCCAA
GCATTGCTACCTTACGCTGTGGAAGAATTGTGCAACGTAGCAGAGTCACTGATTGTTCCTGTCAGAATGGGGATTGCTCGTCCAACTGCA
CCATTTACCCTGGCTAGTACTAGCATAGATGCCATGCAGGGCAGTGAAGAATTATTTTCAGTGGAACCACTACCACCACGACCATCATCT
GATCAGTCTAGCAGCTCCAGTCAGTCTCAGTCATCCTACATCATCAGGAATCCACAGCAGAGGCGCATCAGCCAGTCACAGCCCGTTCGG
GGCAGAGATGAAGAACAGGATGATATTGTTTCAGCAGATGTGGAAGAGGTTGAGGTGGTGGAGGGTGTGGCTGGAGAAGAGGATCATCAT
GATGAACAGGAAGAACACGGGGAAGAAAATGCTGAGGCAGAGGGACAACATGATGAGCATGATGAAGACGGGAGTGATATGGAGCTGGAC
TTGTTAGCAGCAGCTGAAACAGAAAGTGATAGTGAAAGTAACCACAGCAACCAAGATAATGCTAGTGGGCGCAGAAGCGTTGTCACTGCA
GCAACTGCTGGTTCAGAAGCAGGAGCAAGCAGTGTTCCTGCCTTCTTTTCTGAAGATGATTCTCAATCGAATGACTCAAGTGATTCTGAT
AGCAGTAGTAGTCAGAGTGACGACATAGAACAGGAGACCTTTATGCTTGATGAGCCATTAGAAAGAACCACAAATAGCTCCCATGCCAAT
GGTGCTGCCCAAGCTCCCCGTTCAATGCAGTGGGCTGTCCGCAACACCCAGCATCAGCGAGCAGCCAGTACAGCCCCTTCCAGTACATCT
ACACCAGCAGCAAGTTCAGCGGGTTTGATTTATATTGATCCTTCAAACTTACGCCGGAGTGGTACCATCAGTACAAGTGCTGCAGCTGCA
GCAGCTGCTTTGGAAGCTAGCAACGCCAGCAGTTACCTAACATCTGCAAGCAGTTTAGCCAGGGCTTACAGCATTGTCATTAGACAAATC
TCGGACTTGATGGGCCTTATTCCTAAGTATAATCACCTAGTATACTCTCAGATTCCAGCAGCTGTGAAATTGACTTACCAAGATGCAGTA
AACTTACAGAACTATGTAGAAGAAAAGCTTATTCCCACTTGGAACTGGATGGTCAGTATTATGGATTCTACTGAAGCTCAATTACGTTAT
GGTTCTGCATTAGCATCTGCTGGTGATCCTGGACATCCAAATCATCCTCTTCACGCTTCTCAGAATTCAGCGAGAAGAGAGAGGATGACT
GCGCGAGAAGAAGCTAGCTTACGAACACTTGAAGGCAGACGACGTGCCACCTTGCTTAGCGCCCGTCAAGGAATGATGTCTGCACGAGGA
GACTTCCTAAATTATGCTCTGTCTCTAATGCGGTCTCATAATGATGAGCATTCTGATGTTCTTCCAGTTTTGGATGTTTGCTCATTGAAG
CATGTGGCATATGTTTTTCAAGCACTTATATACTGGATTAAGGCAATGAATCAGCAGACAACATTGGATACACCTCAACTAGAACGCAAA
AGGACGCGAGAACTCTTGGAACTGGGTATTGATAATGAAGATTCAGAACATGAAAATGATGATGACACCAATCAAAGTGCTACTTTGAAT
GATAAGGATGATGACTCTCTTCCTGCAGAAACTGGCCAAAACCATCCATTTTTCCGACGTTCAGACTCCATGACATTCCTTGGGTGTATA
CCCCCAAATCCATTTGAAGTGCCTCTGGCTGAAGCCATCCCCTTGGCTGATCAGCCACATCTGTTGCAGCCAAATGCTAGAAAGGAGGAT
CTTTTTGGCCGTCCAAGTCAGGGTCTTTATTCTTCATCTGCCAGTAGTGGGAAATGTTTAATGGAGGTTACAGTGGATAGAAACTGCCTA
GAGGTTCTTCCAACAAAAATGTCTTATGCTGCCAATCTGAAAAATGTAATGAACATGCAAAACCGGCAAAAAAAAGAAGGGGAAGAACAG
CCCGTGCTGCCAGAAGAAACTGAGAGTTCAAAACCAGGGCCATCTGCTCATGATCTTGCTGCACAATTAAAAAGTAGCTTACTAGCAGAA
ATAGGACTTACTGAAAGTGAAGGGCCACCTCTCACATCTTTCAGGCCACAGTGTAGCTTTATGGGAATGGTTATTTCCCATGATATGCTG
CTAGGACGTTGGCGCCTTTCTTTAGAACTGTTCGGCAGGGTATTCATGGAAGATGTTGGAGCAGAACCTGGATCAATCCTAACTGAATTG
GGTGGTTTTGAGGTAAAAGAATCAAAATTCCGCAGAGAAATGGAAAAACTGAGAAACCAGCAGTCAAGAGATTTGTCACTAGAGGTTGAT
CGGGATCGAGATCTTCTCATTCAGCAGACTATGAGGCAGCTTAACAATCACTTTGGTCGAAGATGTGCTACTACACCAATGGCTGTACAC
AGAGTAAAAGTCACATTTAAGGATGAGCCAGGAGAGGGCAGTGGTGTAGCACGAAGTTTTTATACAGCCATTGCACAAGCATTTTTATCA
AATGAAAAATTGCCAAATCTAGAGTGTATCCAAAATGCCAACAAAGGCACCCACACAAGTTTAATGCAGAGATTAAGGAACCGAGGAGAG
AGAGACCGGGAAAGGGAGAGAGAAAGGGAAATGAGGAGGAGTAGTGGTTTGCGAGCAGGTTCTCGGAGGGACCGGGATAGAGACTTTAGA
AGACAGCTTTCCATCGACACTAGGCCCTTTAGACCAGCCTCTGAAGGGAATCCTAGCGATGATCCTGAGCCTTTGCCAGCACATCGGCAG
GCACTTGGAGAGAGGCTTTATCCTCGTGTACAAGCAATGCAACCAGCATTTGCAAGTAAAATCACTGGCATGTTGTTGGAATTATCCCCA
GCTCAGCTGCTTCTCCTTCTAGCAAGTGAGGATTCTCTGAGAGCAAGAGTGGATGAGGCCATGGAACTCATTATTGCACATGGACGGGAA
AATGGAGCTGATAGTATCCTGGATCTTGGATTAGTAGACTCCTCAGAAAAGGTACAGGAAAACCGAAAGCGCCATGGCTCTAGTCGAAGT
GTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACCAACCTGGGAAAAGAGGATTTTATACTCCA
AGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTGGACTATGTCTGTTACAGAATGAACTATGT
CCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATGATTTTGCTTTTTTTGATCCTGTAATGTAT
GAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAGCAATGGATTTGGCATTTGCAATTGACCTG
TGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCACTCCACAGAATGTATATGAGTATGTGCGG
AAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCA
TTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTC
AATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAGTAGAGAAGATGAGCATGACAGAACGA
CAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCA
CCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAA
TTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTA
GATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCCCCTGGTGGTACCTTAAAGAGATAAAATGCAGACATT
CCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGCTATATTGGTTTGCTAGTCACCAACTTCTGGGTCTAACCC
CAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTATCTTTTTGCTGAGGGGGAAAAAATGTAAATGTTCTGAAAATTCAC
TGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATAGGGAATTTCAAAATAAAAAATTAAGTATGTTCTGTGTTT
TCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGTATCATGTATATGGAACTTGTAAAAAAGTTCTCGACATTC

>2670_2670_1_AFF1-UBR5_AFF1_chr4_87928576_ENST00000307808_UBR5_chr8_103373854_ENST00000220959_length(amino acids)=2783AA_BP=5
MAAQSRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAFLLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPG
RTSDSPWFLSGSETLGRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQV
VLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRR
SSLSRLGSSRVLLLPLERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDLQWWPDKDGTKFICIG
ALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTY
SELQGERIVSLHCCALYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGI
PKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEK
VNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTP
KKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKD
CMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHR
CDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHE
AGASSSDHQDPVSPPIAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDS
VVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTG
AEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHL
LLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLP
EEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQ
PIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQ
RRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDN
ASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQR
AASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPA
AVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLS
ARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHEND
DDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCL
MEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSF
MGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGR
RCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAG
SRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEA
MELIIAHGRENGADSILDLGLVDSSEKVQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRIL
GLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPV
TPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWS

--------------------------------------------------------------
>2670_2670_2_AFF1-UBR5_AFF1_chr4_87928576_ENST00000307808_UBR5_chr8_103373854_ENST00000520539_length(transcript)=10065nt_BP=437nt
GGCAATTTCTTTTCCTTTCTAACTGTGGCCCGCGTTGTGCTGTTGCTGGGCAGGCGTTGGGCGCCGGCGGTCTTCGAGCGTGGGGGCCCG
CTGGCTTTCCCTTCTCAGAAACTGCGCCGGGGGCGCTCGCTTGCCCCGGATTCGGACGCGGCGCTCCCCGGGCTCGTCTGAAGTGCAGAT
CGCCGCAGAGGCCCCAGTGCCCGGATGTCCATCAGGATTAGCGCGAGCCAATACGGGCCGAGCCCGGGGCTGCGCCGAGGACGCCCGGGG
CTCGAGAGCAGGTAGTCCCGTAACATCGGGGCGCCGCGCCGGGACGCGTCCCCGCCCGGCTCCGCCAAATGGTGAGCGCGGCGCTGGCAG
CAGGGCCCGCGGGGTGAAGGCGCTCATGGACGGAAGACCCCTGGCTCTATAAGCTGAATTATGGCAGCCCAGTCAAGGTTACGAGAAGTT
TCTGAGAAGCTGAACAAATATAATTTAAACAGCCACCCCCCTTTGAATGTATTGGAACAGGCTACTATTAAACAGTGTGTGGTGGGACCA
AATCATGCTGCCTTTCTTCTTGAGGATGGTAGAGTTTGCAGGATTGGTTTTTCAGTACAGCCAGACAGATTGGAATTGGGTAAACCTGAT
AATAATGATGGGTCAAAGTTGAACAGCAACTCGGGGGCAGGGAGGACGTCAAGGCCTGGTAGGACAAGCGACTCTCCATGGTTTCTCTCA
GGTTCTGAGACTCTAGGCAGGCTGGCAGGCAACACCTTAGGAAGCCGCTGGAGTTCTGGAGTGGGTGGAAGTGGTGGAGGATCCTCTGGT
AGGTCATCAGCTGGAGCTCGAGATTCCCGCCGGCAGACTCGAGTTATTCGGACAGGACGGGATCGAGGGTCTGGGCTTTTGGGCAGTCAG
CCCCAGCCAGTTATTCCAGCATCTGTCATTCCAGAGGAGCTGATTTCACAGGCCCAAGTTGTTTTACAAGGCAAATCCAGAAGTGTCATT
ATTCGAGAACTTCAGAGAACAAATCTTGATGTGAACCTTGCTGTAAATAATTTACTTAGCCGGGATGATGAAGATGGAGATGATGGGGAT
GATACAGCCAGCGAATCTTATTTGCCTGGAGAGGATCTTATGTCTCTCCTTGATGCCGACATTCATTCTGCCCACCCAAGTGTCATTATT
GATGCAGATGCCATGTTTTCTGAAGACATTAGCTATTTTGGTTACCCTTCTTTTCGTCGTTCATCACTTTCCAGGCTAGGCTCATCTCGA
GTTCTCCTTCTTCCCTTAGAGAGAGACTCTGAGCTGTTGCGTGAACGTGAATCCGTTTTACGTTTACGTGAACGAAGGTGGCTTGATGGA
GCCTCATTTGATAATGAAAGGGGTTCTACCAGCAAGGAAGGAGAGCCAAACTTGGATAAGAAGAATACACCTGTTCAAAGTCCAGTATCT
CTAGGAGAAGATTTGCAGTGGTGGCCTGATAAGGATGGAACAAAATTCATCTGTATTGGGGCTCTGTATTCTGAACTTCTGGCTGTCAGC
AGTAAAGGAGAACTTTATCAGTGGAAATGGAGTGAATCTGAGCCTTACAGAAATGCCCAGAATCCTTCATTACATCATCCACGAGCAACA
TTTTTGGGGTTAACCAATGAAAAGATAGTCCTCCTGTCTGCAAATAGCATAAGAGCAACTGTAGCTACAGAAAATAACAAGGTTGCTACA
TGGGTGGATGAAACTTTAAGTTCTGTGGCTTCTAAATTAGAGCACACTGCTCAGACTTACTCTGAACTTCAAGGAGAGCGGATAGTTTCT
TTACATTGCTGTGCCCTTTACACCTGCGCTCAGCTGGAAAACAGTTTATATTGGTGGGGTGTAGTTCCTTTTAGTCAAAGGAAGAAAATG
TTAGAGAAAGCTAGAGCAAAAAATAAAAAGCCTAAATCCAGTGCTGGTATTTCTTCAATGCCGAACATCACTGTTGGTACCCAGGTATGC
TTGAGAAATAATCCTCTTTATCATGCTGGAGCAGTTGCATTTTCAATTAGTGCTGGGATTCCTAAAGTTGGTGTCTTAATGGAGTCAGTT
TGGAATATGAATGACAGCTGTAGATTTCAACTTAGATCTCCTGAAAGCTTGAAAAACATGGAAAAAGCTAGCAAAACTACTGAAGCTAAG
CCTGAAAGTAAGCAGGAGCCAGTGAAAACAGAAATGGGTCCTCCACCATCTCCAGCATCCACGTGTAGTGATGCATCCTCAATTGCCAGC
AGTGCATCAATGCCATACAAACGACGACGGTCAACCCCTGCACCAAAAGAAGAGGAAAAGGTGAATGAAGAGCAGTGGTCTCTTCGGGAA
GTGGTTTTTGTGGAAGATGTCAAGAATGTTCCTGTTGGCAAGGTGCTAAAAGTAGATGGTGCCTATGTTGCTGTAAAATTTCCAGGAACC
TCCAGTAATACTAACTGTCAGAACAGCTCTGGTCCAGATGCTGACCCTTCTTCTCTCCTGCAGGATTGTAGGTTACTTAGAATTGATGAA
TTGCAGGTTGTCAAAACTGGTGGAACACCGAAGGTTCCCGACTGTTTCCAAAGGACTCCTAAAAAGCTTTGTATACCTGAAAAAACAGAA
ATATTAGCAGTGAATGTAGATTCCAAAGGTGTTCATGCTGTTCTGAAGACTGGAAATTGGGTACGATACTGTATCTTTGATCTTGCTACA
GGAAAAGCAGAACAGGAAAATAATTTTCCTACAAGCAGCATTGCTTTCCTTGGTCAGAATGAGAGGAATGTAGCCATTTTCACTGCTGGA
CAGGAATCTCCCATTATTCTTCGAGATGGAAATGGTACCATCTACCCAATGGCCAAAGATTGCATGGGAGGAATAAGGGATCCCGATTGG
CTGGATCTTCCACCTATTAGTAGTCTTGGAATGGGTGTGCATTCTTTAATAAATCTTCCTGCCAATTCAACAATCAAAAAGAAAGCTGCT
GTTATCATCATGGCTGTAGAGAAACAAACCTTAATGCAACACATTCTGCGCTGTGACTATGAGGCCTGTCGACAATATCTAATGAATCTT
GAGCAAGCGGTTGTTTTAGAGCAGAATCTACAGATGCTGCAGACATTCATCAGCCACAGATGTGATGGAAATCGAAATATTTTGCATGCT
TGTGTATCAGTTTGCTTTCCAACCAGCAATAAAGAAACTAAAGAAGAAGAGGAAGCGGAGCGTTCTGAAAGAAATACATTTGCAGAAAGG
CTTTCTGCTGTTGAGGCCATTGCAAATGCAATATCAGTTGTTTCAAGTAATGGCCCAGGTAATCGGGCTGGATCATCAAGTAGCCGAAGT
TTGAGATTACGGGAAATGATGAGACGTTCGTTGAGAGCAGCTGGTTTGGGTAGACATGAAGCTGGAGCTTCATCCAGTGACCACCAGGAT
CCAGTTTCACCCCCCATAGCTCCCCCTAGTTGGGTTCCTGACCCTCCTGCGATGGATCCTGATGGTGACATTGATTTTATCCTGGCCCCC
GCTGTGGGATCTCTTACCACAGCAGCAACCGGTACTGGTCAAGGACCAAGCACCTCCACTATTCCAGGTCCTTCCACAGAGCCATCTGTA
GTAGAATCCAAGGATCGAAAGGCGAATGCTCATTTTATATTGAAATTGTTATGTGACAGTGTGGTTCTCCAGCCCTATCTACGAGAACTT
CTTTCTGCCAAGGATGCAAGAGGGATGACCCCATTTATGTCAGCTGTAAGTGGCCGAGCTTATCCTGCTGCAATTACCATCTTAGAAACT
GCTCAGAAAATTGCAAAAGCTGAAATATCCTCAAGTGAAAAAGAGGAAGATGTATTCATGGGAATGGTTTGCCCATCAGGTACCAACCCT
GATGACTCTCCTTTATATGTTTTATGTTGTAATGACACTTGCAGTTTTACATGGACTGGAGCAGAGCACATTAACCAGGATATTTTTGAG
TGTCGAACTTGTGGCTTGCTGGAGTCACTGTGTTGTTGTACGGAATGTGCAAGGGTTTGTCATAAAGGTCATGATTGCAAACTCAAACGG
ACATCACCAACAGCCTACTGTGATTGTTGGGAGAAATGTAAATGTAAAACTCTTATTGCTGGACAGAAATCTGCTCGTCTTGATCTACTT
TATCGCCTGCTCACTGCTACTAATCTGGTTACTCTGCCAAACAGCAGGGGAGAGCACCTCTTACTATTCTTAGTACAGACAGTCGCAAGG
CAGACGGTGGAGCATTGTCAATACAGGCCACCTCGAATCAGGGAAGATCGTAACCGAAAAACAGCCAGTCCTGAAGATTCAGATATGCCA
GATCATGATTTAGAGCCTCCAAGATTTGCCCAGCTTGCATTGGAGCGTGTTCTACAGGACTGGAATGCCTTGAAATCTATGATTATGTTT
GGGTCGCAGGAGAATAAAGACCCTCTTAGTGCCAGCAGTAGAATAGGCCATCTTTTGCCAGAAGAGCAAGTATACCTCAATCAGCAAAGT
GGCACAATTCGGCTGGACTGTTTCACTCATTGCCTTATAGTTAAGTGTACAGCAGATATTTTGCTTTTAGATACTCTACTAGGTACACTA
GTGAAAGAACTCCAAAACAAATATACACCTGGACGTAGAGAAGAAGCTATTGCTGTGACAATGAGGTTTCTACGTTCAGTGGCAAGAGTT
TTTGTTATTCTGAGTGTGGAAATGGCTTCATCCAAAAAGAAAAACAACTTTATTCCACAGCCAATTGGAAAATGCAAGCGTGTATTCCAA
GCATTGCTACCTTACGCTGTGGAAGAATTGTGCAACGTAGCAGAGTCACTGATTGTTCCTGTCAGAATGGGGATTGCTCGTCCAACTGCA
CCATTTACCCTGGCTAGTACTAGCATAGATGCCATGCAGGGCAGTGAAGAATTATTTTCAGTGGAACCACTACCACCACGACCATCATCT
GATCAGTCTAGCAGCTCCAGTCAGTCTCAGTCATCCTACATCATCAGGAATCCACAGCAGAGGCGCATCAGCCAGTCACAGCCCGTTCGG
GGCAGAGATGAAGAACAGGATGATATTGTTTCAGCAGATGTGGAAGAGGTTGAGGTGGTGGAGGGTGTGGCTGGAGAAGAGGATCATCAT
GATGAACAGGAAGAACACGGGGAAGAAAATGCTGAGGCAGAGGGACAACATGATGAGCATGATGAAGACGGGAGTGATATGGAGCTGGAC
TTGTTAGCAGCAGCTGAAACAGAAAGTGATAGTGAAAGTAACCACAGCAACCAAGATAATGCTAGTGGGCGCAGAAGCGTTGTCACTGCA
GCAACTGCTGGTTCAGAAGCAGGAGCAAGCAGTGTTCCTGCCTTCTTTTCTGAAGATGATTCTCAATCGAATGACTCAAGTGATTCTGAT
AGCAGTAGTAGTCAGAGTGACGACATAGAACAGGAGACCTTTATGCTTGATGAGCCATTAGAAAGAACCACAAATAGCTCCCATGCCAAT
GGTGCTGCCCAAGCTCCCCGTTCAATGCAGTGGGCTGTCCGCAACACCCAGCATCAGCGAGCAGCCAGTACAGCCCCTTCCAGTACATCT
ACACCAGCAGCAAGTTCAGCGGGTTTGATTTATATTGATCCTTCAAACTTACGCCGGAGTGGTACCATCAGTACAAGTGCTGCAGCTGCA
GCAGCTGCTTTGGAAGCTAGCAACGCCAGCAGTTACCTAACATCTGCAAGCAGTTTAGCCAGGGCTTACAGCATTGTCATTAGACAAATC
TCGGACTTGATGGGCCTTATTCCTAAGTATAATCACCTAGTATACTCTCAGATTCCAGCAGCTGTGAAATTGACTTACCAAGATGCAGTA
AACTTACAGAACTATGTAGAAGAAAAGCTTATTCCCACTTGGAACTGGATGGTCAGTATTATGGATTCTACTGAAGCTCAATTACGTTAT
GGTTCTGCATTAGCATCTGCTGGTGATCCTGGACATCCAAATCATCCTCTTCACGCTTCTCAGAATTCAGCGAGAAGAGAGAGGATGACT
GCGCGAGAAGAAGCTAGCTTACGAACACTTGAAGGCAGACGACGTGCCACCTTGCTTAGCGCCCGTCAAGGAATGATGTCTGCACGAGGA
GACTTCCTAAATTATGCTCTGTCTCTAATGCGGTCTCATAATGATGAGCATTCTGATGTTCTTCCAGTTTTGGATGTTTGCTCATTGAAG
CATGTGGCATATGTTTTTCAAGCACTTATATACTGGATTAAGGCAATGAATCAGCAGACAACATTGGATACACCTCAACTAGAACGCAAA
AGGACGCGAGAACTCTTGGAACTGGGTATTGATAATGAAGATTCAGAACATGAAAATGATGATGACACCAATCAAAGTGCTACTTTGAAT
GATAAGGATGATGACTCTCTTCCTGCAGAAACTGGCCAAAACCATCCATTTTTCCGACGTTCAGACTCCATGACATTCCTTGGGTGTATA
CCCCCAAATCCATTTGAAGTGCCTCTGGCTGAAGCCATCCCCTTGGCTGATCAGCCACATCTGTTGCAGCCAAATGCTAGAAAGGAGGAT
CTTTTTGGCCGTCCAAGTCAGGGTCTTTATTCTTCATCTGCCAGTAGTGGGAAATGTTTAATGGAGGTTACAGTGGATAGAAACTGCCTA
GAGGTTCTTCCAACAAAAATGTCTTATGCTGCCAATCTGAAAAATGTAATGAACATGCAAAACCGGCAAAAAAAAGAAGGGGAAGAACAG
CCCGTGCTGCCAGAAGAAACTGAGAGTTCAAAACCAGGGCCATCTGCTCATGATCTTGCTGCACAATTAAAAAGTAGCTTACTAGCAGAA
ATAGGACTTACTGAAAGTGAAGGGCCACCTCTCACATCTTTCAGGCCACAGTGTAGCTTTATGGGAATGGTTATTTCCCATGATATGCTG
CTAGGACGTTGGCGCCTTTCTTTAGAACTGTTCGGCAGGGTATTCATGGAAGATGTTGGAGCAGAACCTGGATCAATCCTAACTGAATTG
GGTGGTTTTGAGGTAAAAGAATCAAAATTCCGCAGAGAAATGGAAAAACTGAGAAACCAGCAGTCAAGAGATTTGTCACTAGAGGTTGAT
CGGGATCGAGATCTTCTCATTCAGCAGACTATGAGGCAGCTTAACAATCACTTTGGTCGAAGATGTGCTACTACACCAATGGCTGTACAC
AGAGTAAAAGTCACATTTAAGGATGAGCCAGGAGAGGGCAGTGGTGTAGCACGAAGTTTTTATACAGCCATTGCACAAGCATTTTTATCA
AATGAAAAATTGCCAAATCTAGAGTGTATCCAAAATGCCAACAAAGGCACCCACACAAGTTTAATGCAGAGATTAAGGAACCGAGGAGAG
AGAGACCGGGAAAGGGAGAGAGAAAGGGAAATGAGGAGGAGTAGTGGTTTGCGAGCAGGTTCTCGGAGGGACCGGGATAGAGACTTTAGA
AGACAGCTTTCCATCGACACTAGGCCCTTTAGACCAGCCTCTGAAGGGAATCCTAGCGATGATCCTGAGCCTTTGCCAGCACATCGGCAG
GCACTTGGAGAGAGGCTTTATCCTCGTGTACAAGCAATGCAACCAGCATTTGCAAGTAAAATCACTGGCATGTTGTTGGAATTATCCCCA
GCTCAGCTGCTTCTCCTTCTAGCAAGTGAGGATTCTCTGAGAGCAAGAGTGGATGAGGCCATGGAACTCATTATTGCACATGGACGGGAA
AATGGAGCTGATAGTATCCTGGATCTTGGATTAGTAGACTCCTCAGAAAAGGTACAGCAGGAAAACCGAAAGCGCCATGGCTCTAGTCGA
AGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACCAACCTGGGAAAAGAGGATTTTATACT
CCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTGGACTATGTCTGTTACAGAATGAACTA
TGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATGATTTTGCTTTTTTTGATCCTGTAATG
TATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAGCAATGGATTTGGCATTTGCAATTGAC
CTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCACTCCACAGAATGTATATGAGTATGTG
CGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAGGTCTACTAGATGTGCTTCCAAAAAAT
TCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGCAAATGCTGATCAGTTTTACCTCT
TTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAGTAGAGAAGATGAGCATGACAGAA
CGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGCCTATGCCCTCAATCACAATAAGA
CCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATTCCTCTAAACAGATTCTCAAACAG
AAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCTGTGTAATATTACTAGCAAATTTT
GTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCCCCTGGTGGTACCTTAAAGAGATAAAATGCAGAC
ATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGCTATATTGGTTTGCTAGTCACCAACTTCTGGGTCTAA
CCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTATCTTTTTGCTGAGGGGGAAAAAATGTAAATGTTCTGAAAATT
CACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATAGGGAATTTCAAAATAAAAAATTAAGTATGTTCTGTG
TTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGTATCATGTATATGGAACTTGTAAAAAAGTTCTCGACA
TTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTATTGCGGTTTGACTGCATTGAGCTCTAGGATATTAAATGATA
TCACTAATATTTTGCATGTAATTTGCTCATTTGAGTGAGGGCACTTTTTTTGTACATATGATGGGGCCAATGCACAATACTTTTATCACA
ATCAACTTTTTCTTTGTATCCCTATTTCAATGAGCAGTCAGTCTCAAGAGGTTACTGCACTTCAGTTCTAACTAGACATTTGTACTAAGG
TATTTCAGTTATGTAAACTCAGCCTGGGCACTTTCTGATAACTGTAAAATGTTTTATAAGATCATGATTATTGAAGATACATTTTGGAAA
ATTTTAAATGTTCGTGAGCAGCTTAACTACTTTTGTATCTAGCCTTTTTTAAGTATCTTGTTACATTTACTTTTTTAAATAAAGAAATTA
CAGAAGAAATGTCAAGTAATATTGAAGAAACAATAGTTTTTATTTATGTAGTTGTACATTTTTAAACTAAGGGCAATACACTGACATGGT
TATGTGCATAAAAATTTTGACTTAAAGAACTGGAAGTTTATATACACCTGGACTATAAGAAACAGAAGAAAATCAGTCCACATTTTACAG
TTAGCAGAGAATCCTAAATGGCACTGGCCTGGCCACCTTTTCATTTTACAAATGGGGGAAGTGAAGTGTGACCCCTTACTTGGCATAGGA

>2670_2670_2_AFF1-UBR5_AFF1_chr4_87928576_ENST00000307808_UBR5_chr8_103373854_ENST00000520539_length(amino acids)=2784AA_BP=5
MAAQSRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAFLLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPG
RTSDSPWFLSGSETLGRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQV
VLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRR
SSLSRLGSSRVLLLPLERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDLQWWPDKDGTKFICIG
ALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTY
SELQGERIVSLHCCALYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGI
PKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEK
VNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTP
KKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKD
CMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHR
CDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHE
AGASSSDHQDPVSPPIAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDS
VVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTG
AEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHL
LLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLP
EEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQ
PIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQ
RRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDN
ASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQR
AASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPA
AVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLS
ARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHEND
DDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCL
MEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSF
MGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGR
RCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAG
SRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEA
MELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRI
LGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIP
VTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFW

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Fusion Gene PPI Analysis for AFF1-UBR5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AFF1-UBR5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AFF1-UBR5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource