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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MSH2-SLC3A1 (FusionGDB2 ID:HG4436TG6519)

Fusion Gene Summary for MSH2-SLC3A1

check button Fusion gene summary
Fusion gene informationFusion gene name: MSH2-SLC3A1
Fusion gene ID: hg4436tg6519
HgeneTgene
Gene symbol

MSH2

SLC3A1

Gene ID

4436

6519

Gene namemutS homolog 2solute carrier family 3 member 1
SynonymsCOCA1|FCC1|HNPCC|HNPCC1|LCFS2|hMSH2ATR1|CSNU1|D2H|NBAT|RBAT
Cytomap('MSH2')('SLC3A1')

2p21-p16.3

2p21

Type of geneprotein-codingprotein-coding
DescriptionDNA mismatch repair protein Msh2DNA mismatch repair protein Msh2 transcriptmutS homolog 2, colon cancer, nonpolyposis type 1neutral and basic amino acid transport protein rBATB(0,+)-type amino acid transport proteinSLC3A1 variant BSLC3A1 variant CSLC3A1 variant DSLC3A1 variant ESLC3A1 variant FSLC3A1 variant Gamino acid transporter 1solute carrier family 3 (amino acid
Modification date2020032220200313
UniProtAcc

P43246

.
Ensembl transtripts involved in fusion geneENST00000233146, ENST00000406134, 
ENST00000543555, ENST00000461394, 
Fusion gene scores* DoF score15 X 12 X 10=18001 X 2 X 1=2
# samples 232
** MAII scorelog2(23/1800*10)=-2.96829114027266
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Context

PubMed: MSH2 [Title/Abstract] AND SLC3A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMSH2(47637511)-SLC3A1(44539725), # samples:3
Anticipated loss of major functional domain due to fusion event.MSH2-SLC3A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MSH2-SLC3A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMSH2

GO:0006281

DNA repair

8942985

HgeneMSH2

GO:0006298

mismatch repair

7923193|11555625

HgeneMSH2

GO:0006301

postreplication repair

7923193

HgeneMSH2

GO:0045910

negative regulation of DNA recombination

17715146

HgeneMSH2

GO:0051096

positive regulation of helicase activity

17715146


check buttonFusion gene breakpoints across MSH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SLC3A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A04U-01AMSH2chr2

47637511

-SLC3A1chr2

44539725

+
ChimerDB4BRCATCGA-A2-A04U-01AMSH2chr2

47637511

+SLC3A1chr2

44539725

+
ChimerDB4BRCATCGA-A2-A04UMSH2chr2

47637511

+SLC3A1chr2

44539724

+


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Fusion Gene ORF analysis for MSH2-SLC3A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000233146ENST00000409229MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000233146ENST00000409229MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000233146ENST00000409294MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000233146ENST00000409294MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000233146ENST00000409380MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000233146ENST00000409380MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000233146ENST00000409740MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000233146ENST00000409740MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000233146ENST00000409741MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000233146ENST00000409741MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000233146ENST00000410056MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000233146ENST00000410056MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000406134ENST00000409229MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000406134ENST00000409229MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000406134ENST00000409294MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000406134ENST00000409294MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000406134ENST00000409380MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000406134ENST00000409380MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000406134ENST00000409740MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000406134ENST00000409740MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000406134ENST00000409741MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000406134ENST00000409741MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000406134ENST00000410056MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000406134ENST00000410056MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000543555ENST00000409229MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000543555ENST00000409229MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000543555ENST00000409294MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000543555ENST00000409294MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000543555ENST00000409380MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000543555ENST00000409380MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000543555ENST00000409740MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000543555ENST00000409740MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000543555ENST00000409741MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000543555ENST00000409741MSH2chr2

47637511

+SLC3A1chr2

44539724

+
5CDS-intronENST00000543555ENST00000410056MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000543555ENST00000410056MSH2chr2

47637511

+SLC3A1chr2

44539724

+
In-frameENST00000233146ENST00000260649MSH2chr2

47637511

+SLC3A1chr2

44539725

+
In-frameENST00000233146ENST00000260649MSH2chr2

47637511

+SLC3A1chr2

44539724

+
In-frameENST00000233146ENST00000409387MSH2chr2

47637511

+SLC3A1chr2

44539725

+
In-frameENST00000233146ENST00000409387MSH2chr2

47637511

+SLC3A1chr2

44539724

+
In-frameENST00000406134ENST00000260649MSH2chr2

47637511

+SLC3A1chr2

44539725

+
In-frameENST00000406134ENST00000260649MSH2chr2

47637511

+SLC3A1chr2

44539724

+
In-frameENST00000406134ENST00000409387MSH2chr2

47637511

+SLC3A1chr2

44539725

+
In-frameENST00000406134ENST00000409387MSH2chr2

47637511

+SLC3A1chr2

44539724

+
In-frameENST00000543555ENST00000260649MSH2chr2

47637511

+SLC3A1chr2

44539725

+
In-frameENST00000543555ENST00000260649MSH2chr2

47637511

+SLC3A1chr2

44539724

+
In-frameENST00000543555ENST00000409387MSH2chr2

47637511

+SLC3A1chr2

44539725

+
In-frameENST00000543555ENST00000409387MSH2chr2

47637511

+SLC3A1chr2

44539724

+
intron-3CDSENST00000461394ENST00000260649MSH2chr2

47637511

+SLC3A1chr2

44539725

+
intron-3CDSENST00000461394ENST00000260649MSH2chr2

47637511

+SLC3A1chr2

44539724

+
intron-3CDSENST00000461394ENST00000409387MSH2chr2

47637511

+SLC3A1chr2

44539725

+
intron-3CDSENST00000461394ENST00000409387MSH2chr2

47637511

+SLC3A1chr2

44539724

+
intron-intronENST00000461394ENST00000409229MSH2chr2

47637511

+SLC3A1chr2

44539725

+
intron-intronENST00000461394ENST00000409229MSH2chr2

47637511

+SLC3A1chr2

44539724

+
intron-intronENST00000461394ENST00000409294MSH2chr2

47637511

+SLC3A1chr2

44539725

+
intron-intronENST00000461394ENST00000409294MSH2chr2

47637511

+SLC3A1chr2

44539724

+
intron-intronENST00000461394ENST00000409380MSH2chr2

47637511

+SLC3A1chr2

44539725

+
intron-intronENST00000461394ENST00000409380MSH2chr2

47637511

+SLC3A1chr2

44539724

+
intron-intronENST00000461394ENST00000409740MSH2chr2

47637511

+SLC3A1chr2

44539725

+
intron-intronENST00000461394ENST00000409740MSH2chr2

47637511

+SLC3A1chr2

44539724

+
intron-intronENST00000461394ENST00000409741MSH2chr2

47637511

+SLC3A1chr2

44539725

+
intron-intronENST00000461394ENST00000409741MSH2chr2

47637511

+SLC3A1chr2

44539724

+
intron-intronENST00000461394ENST00000410056MSH2chr2

47637511

+SLC3A1chr2

44539725

+
intron-intronENST00000461394ENST00000410056MSH2chr2

47637511

+SLC3A1chr2

44539724

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000233146MSH2chr247637511+ENST00000260649SLC3A1chr244539725+24498682231593456
ENST00000233146MSH2chr247637511+ENST00000409387SLC3A1chr244539725+17918682231230335
ENST00000543555MSH2chr247637511+ENST00000260649SLC3A1chr244539725+216758671311434
ENST00000543555MSH2chr247637511+ENST00000409387SLC3A1chr244539725+15095867948313
ENST00000406134MSH2chr247637511+ENST00000260649SLC3A1chr244539725+2288707621432456
ENST00000406134MSH2chr247637511+ENST00000409387SLC3A1chr244539725+1630707621069335
ENST00000233146MSH2chr247637511+ENST00000260649SLC3A1chr244539724+24498682231593456
ENST00000233146MSH2chr247637511+ENST00000409387SLC3A1chr244539724+17918682231230335
ENST00000543555MSH2chr247637511+ENST00000260649SLC3A1chr244539724+216758671311434
ENST00000543555MSH2chr247637511+ENST00000409387SLC3A1chr244539724+15095867948313
ENST00000406134MSH2chr247637511+ENST00000260649SLC3A1chr244539724+2288707621432456
ENST00000406134MSH2chr247637511+ENST00000409387SLC3A1chr244539724+1630707621069335

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000233146ENST00000260649MSH2chr247637511+SLC3A1chr244539725+0.000279610.9997204
ENST00000233146ENST00000409387MSH2chr247637511+SLC3A1chr244539725+0.0002757990.9997242
ENST00000543555ENST00000260649MSH2chr247637511+SLC3A1chr244539725+0.0002207530.9997793
ENST00000543555ENST00000409387MSH2chr247637511+SLC3A1chr244539725+0.0003825710.99961746
ENST00000406134ENST00000260649MSH2chr247637511+SLC3A1chr244539725+0.0002662090.99973375
ENST00000406134ENST00000409387MSH2chr247637511+SLC3A1chr244539725+0.0002369390.9997631
ENST00000233146ENST00000260649MSH2chr247637511+SLC3A1chr244539724+0.000279610.9997204
ENST00000233146ENST00000409387MSH2chr247637511+SLC3A1chr244539724+0.0002757990.9997242
ENST00000543555ENST00000260649MSH2chr247637511+SLC3A1chr244539724+0.0002207530.9997793
ENST00000543555ENST00000409387MSH2chr247637511+SLC3A1chr244539724+0.0003825710.99961746
ENST00000406134ENST00000260649MSH2chr247637511+SLC3A1chr244539724+0.0002662090.99973375
ENST00000406134ENST00000409387MSH2chr247637511+SLC3A1chr244539724+0.0002369390.9997631

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Fusion Genomic Features for MSH2-SLC3A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MSH2-SLC3A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:47637511/chr2:44539725)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MSH2

P43246

.
FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand (PubMed:26300262). ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:17611581, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:26300262, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMSH2chr2:47637511chr2:44539724ENST00000233146+316669_676215935.0Nucleotide bindingATP
HgeneMSH2chr2:47637511chr2:44539724ENST00000543555+417669_676149869.0Nucleotide bindingATP
HgeneMSH2chr2:47637511chr2:44539725ENST00000233146+316669_676215935.0Nucleotide bindingATP
HgeneMSH2chr2:47637511chr2:44539725ENST00000543555+417669_676149869.0Nucleotide bindingATP
TgeneSLC3A1chr2:47637511chr2:44539724ENST00000260649610109_685444686.0Topological domainExtracellular
TgeneSLC3A1chr2:47637511chr2:44539724ENST000002606496101_87444686.0Topological domainCytoplasmic
TgeneSLC3A1chr2:47637511chr2:44539725ENST00000260649610109_685444686.0Topological domainExtracellular
TgeneSLC3A1chr2:47637511chr2:44539725ENST000002606496101_87444686.0Topological domainCytoplasmic
TgeneSLC3A1chr2:47637511chr2:44539724ENST0000026064961088_108444686.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneSLC3A1chr2:47637511chr2:44539725ENST0000026064961088_108444686.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for MSH2-SLC3A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55274_55274_1_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000233146_SLC3A1_chr2_44539724_ENST00000260649_length(transcript)=2449nt_BP=868nt
GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC
AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG
GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA
GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA
CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCA
GAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAG
AGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTT
TGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGT
GGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACC
AAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTC
GCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGG
AATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTC
AAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGATGTCCAAAAGACTCAGCC
CAGATCGGCTTTGAAGTTATATCAAGATTTAAGTCTACTTCATGCCAATGAGCTACTCCTCAACAGGGGCTGGTTTTGCCATTTGAGGAA
TGACAGCCACTATGTTGTGTACACAAGAGAGCTGGATGGCATCGACAGAATCTTTATCGTGGTTCTGAATTTTGGAGAATCAACACTGTT
AAATCTACATAATATGATTTCGGGCCTTCCCGCTAAAATGAGAATAAGGTTAAGTACCAATTCTGCCGACAAAGGCAGTAAAGTTGATAC
AAGTGGCATTTTTCTGGACAAGGGAGAGGGACTCATCTTTGAACACAACACGAAGAATCTCCTTCATCGCCAAACAGCTTTCAGAGATAG
ATGCTTTGTTTCCAATCGAGCATGCTATTCCAGTGTACTGAACATACTGTATACCTCGTGTTAGGCACCTTTATGAAGAGATGAAGACAC
TGGCATTTCAGTGGGATTGTAAGCATTTGTAATAGCTTCATGTACAGCATGCTGCTTGGTGAACAATCATTAATTCTTCGATATTTCTGT
AGCTTGAATGTAACTGCTTTAAGAAAGGTTCTCAAATGTTTTGAAAAAAATAAAATGTTTAAAAGTAAATTATGGCTTATAGGAGCTTAT
AACTTTATTCAGATAGCATCAATCAGGGATGACCAGAACACATTAGGACCCCAGATTATTCAAAAACTTTAACGAATTTTAAGGGGAAGA
ATTTTATCTTTTCCCTTAAAATGCAGTCATAGAAATTAGAGGATGACTCACTGCCACAGTGTCTAAAAGCATTTGCTAGCAAAGAGGCAG
GACACTAATTTGTAAACTGCTCAACTGTTCTGACTGGAAGGGAGGCCTGGAGCTCTGCTATCACCAATCCTTCCCTTCCCTCTACTCCAC
ATCCTTCTAAGGAGCATGATTTGAAAATTACTTTCCTAGGTTAATGGGCATGTGCATCAATGGAGAGAATAGTATAAGCAAGTGAGATGT
AGACTAAGCAAAATTTAGATGGAGAAGCACATTTTAAAAAATTAATAACTTAAAAGTCTCAAGTTATTAATTTTTTTTTTGCTAACTCAA
TTGGAAGTAAGACTATGAAATATTTCAGTGTGTTTCCAATTCCCAGTTGAATGCAGTGTTTCAGAATTTCAGGTATTTCTTAAGATCCTC
GAAAACACTGGTGCTGTCAAGTCCAAGTTCCTCGTACAGGAATTTAATTTGGGCTGTAATCTAAAAGAAACACATTAAAAAAATTAAATA

>55274_55274_1_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000233146_SLC3A1_chr2_44539724_ENST00000260649_length(amino acids)=456AA_BP=181
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYD
INTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGI
DRIFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLN

--------------------------------------------------------------
>55274_55274_2_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000233146_SLC3A1_chr2_44539724_ENST00000409387_length(transcript)=1791nt_BP=868nt
GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC
AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG
GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA
GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA
CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCA
GAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAG
AGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTT
TGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGT
GGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACC
AAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTC
GCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGG
AATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTC
AAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGATTCTTGCTCCGTCACCCA
TGCTCGAGTGCAGTGGCGTGATCTCGGCACACTGCAGCCTCTGCTTCCTGGGTTCAAGTGATTCTCCTGCTGCAGCCTCCCAAGTAGCTG
GGATTACAGGTGCACGTCATTATGCCCGGGTAATTTCTGTATTTTTTAGTAGAGATGGTGTTTCACCATGTTGGCCAGGCTGGTCTTGAA
CTCCTGACCTCTGGTGATCTGTCTGCCTTGCCTCCCAAAGTGCTAGGATTACGGGCCTGAGCCACCTTGCCTGGCCTGCAAAATTTGTTT
TTAATAGAAGACACAAGAAATGATTTAAATATTTTATCAACAGAAAACCAGTTCTATCAACTATGGGCCCAGTATGCAGCTTTTAAAAAT
GACAGTTCTATATACATTGATATGAGACCATTTCAAACAGGTATTCAATAAAGTATAGAATGGTAACATATCACCAACTGTGTAAAGAAA
AATATATAAACATATGAAATGATACATTCTGTGCCTATGCAAACATATGATACATTAAAAACAAAAGAACATATAGTGCCTGTCTCTGAG

>55274_55274_2_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000233146_SLC3A1_chr2_44539724_ENST00000409387_length(amino acids)=335AA_BP=181
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYD

--------------------------------------------------------------
>55274_55274_3_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000233146_SLC3A1_chr2_44539725_ENST00000260649_length(transcript)=2449nt_BP=868nt
GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC
AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG
GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA
GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA
CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCA
GAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAG
AGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTT
TGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGT
GGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACC
AAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTC
GCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGG
AATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTC
AAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGATGTCCAAAAGACTCAGCC
CAGATCGGCTTTGAAGTTATATCAAGATTTAAGTCTACTTCATGCCAATGAGCTACTCCTCAACAGGGGCTGGTTTTGCCATTTGAGGAA
TGACAGCCACTATGTTGTGTACACAAGAGAGCTGGATGGCATCGACAGAATCTTTATCGTGGTTCTGAATTTTGGAGAATCAACACTGTT
AAATCTACATAATATGATTTCGGGCCTTCCCGCTAAAATGAGAATAAGGTTAAGTACCAATTCTGCCGACAAAGGCAGTAAAGTTGATAC
AAGTGGCATTTTTCTGGACAAGGGAGAGGGACTCATCTTTGAACACAACACGAAGAATCTCCTTCATCGCCAAACAGCTTTCAGAGATAG
ATGCTTTGTTTCCAATCGAGCATGCTATTCCAGTGTACTGAACATACTGTATACCTCGTGTTAGGCACCTTTATGAAGAGATGAAGACAC
TGGCATTTCAGTGGGATTGTAAGCATTTGTAATAGCTTCATGTACAGCATGCTGCTTGGTGAACAATCATTAATTCTTCGATATTTCTGT
AGCTTGAATGTAACTGCTTTAAGAAAGGTTCTCAAATGTTTTGAAAAAAATAAAATGTTTAAAAGTAAATTATGGCTTATAGGAGCTTAT
AACTTTATTCAGATAGCATCAATCAGGGATGACCAGAACACATTAGGACCCCAGATTATTCAAAAACTTTAACGAATTTTAAGGGGAAGA
ATTTTATCTTTTCCCTTAAAATGCAGTCATAGAAATTAGAGGATGACTCACTGCCACAGTGTCTAAAAGCATTTGCTAGCAAAGAGGCAG
GACACTAATTTGTAAACTGCTCAACTGTTCTGACTGGAAGGGAGGCCTGGAGCTCTGCTATCACCAATCCTTCCCTTCCCTCTACTCCAC
ATCCTTCTAAGGAGCATGATTTGAAAATTACTTTCCTAGGTTAATGGGCATGTGCATCAATGGAGAGAATAGTATAAGCAAGTGAGATGT
AGACTAAGCAAAATTTAGATGGAGAAGCACATTTTAAAAAATTAATAACTTAAAAGTCTCAAGTTATTAATTTTTTTTTTGCTAACTCAA
TTGGAAGTAAGACTATGAAATATTTCAGTGTGTTTCCAATTCCCAGTTGAATGCAGTGTTTCAGAATTTCAGGTATTTCTTAAGATCCTC
GAAAACACTGGTGCTGTCAAGTCCAAGTTCCTCGTACAGGAATTTAATTTGGGCTGTAATCTAAAAGAAACACATTAAAAAAATTAAATA

>55274_55274_3_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000233146_SLC3A1_chr2_44539725_ENST00000260649_length(amino acids)=456AA_BP=181
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYD
INTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGI
DRIFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLN

--------------------------------------------------------------
>55274_55274_4_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000233146_SLC3A1_chr2_44539725_ENST00000409387_length(transcript)=1791nt_BP=868nt
GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC
AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG
GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA
GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA
CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCA
GAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAG
AGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTT
TGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGT
GGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACC
AAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTC
GCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGG
AATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTC
AAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGATTCTTGCTCCGTCACCCA
TGCTCGAGTGCAGTGGCGTGATCTCGGCACACTGCAGCCTCTGCTTCCTGGGTTCAAGTGATTCTCCTGCTGCAGCCTCCCAAGTAGCTG
GGATTACAGGTGCACGTCATTATGCCCGGGTAATTTCTGTATTTTTTAGTAGAGATGGTGTTTCACCATGTTGGCCAGGCTGGTCTTGAA
CTCCTGACCTCTGGTGATCTGTCTGCCTTGCCTCCCAAAGTGCTAGGATTACGGGCCTGAGCCACCTTGCCTGGCCTGCAAAATTTGTTT
TTAATAGAAGACACAAGAAATGATTTAAATATTTTATCAACAGAAAACCAGTTCTATCAACTATGGGCCCAGTATGCAGCTTTTAAAAAT
GACAGTTCTATATACATTGATATGAGACCATTTCAAACAGGTATTCAATAAAGTATAGAATGGTAACATATCACCAACTGTGTAAAGAAA
AATATATAAACATATGAAATGATACATTCTGTGCCTATGCAAACATATGATACATTAAAAACAAAAGAACATATAGTGCCTGTCTCTGAG

>55274_55274_4_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000233146_SLC3A1_chr2_44539725_ENST00000409387_length(amino acids)=335AA_BP=181
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYD

--------------------------------------------------------------
>55274_55274_5_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000406134_SLC3A1_chr2_44539724_ENST00000260649_length(transcript)=2288nt_BP=707nt
AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC
AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG
GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG
CAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAG
TTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTC
AGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGAC
AGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTC
TCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAG
ACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTT
ACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAA
TGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTG
ATGTCCAAAAGACTCAGCCCAGATCGGCTTTGAAGTTATATCAAGATTTAAGTCTACTTCATGCCAATGAGCTACTCCTCAACAGGGGCT
GGTTTTGCCATTTGAGGAATGACAGCCACTATGTTGTGTACACAAGAGAGCTGGATGGCATCGACAGAATCTTTATCGTGGTTCTGAATT
TTGGAGAATCAACACTGTTAAATCTACATAATATGATTTCGGGCCTTCCCGCTAAAATGAGAATAAGGTTAAGTACCAATTCTGCCGACA
AAGGCAGTAAAGTTGATACAAGTGGCATTTTTCTGGACAAGGGAGAGGGACTCATCTTTGAACACAACACGAAGAATCTCCTTCATCGCC
AAACAGCTTTCAGAGATAGATGCTTTGTTTCCAATCGAGCATGCTATTCCAGTGTACTGAACATACTGTATACCTCGTGTTAGGCACCTT
TATGAAGAGATGAAGACACTGGCATTTCAGTGGGATTGTAAGCATTTGTAATAGCTTCATGTACAGCATGCTGCTTGGTGAACAATCATT
AATTCTTCGATATTTCTGTAGCTTGAATGTAACTGCTTTAAGAAAGGTTCTCAAATGTTTTGAAAAAAATAAAATGTTTAAAAGTAAATT
ATGGCTTATAGGAGCTTATAACTTTATTCAGATAGCATCAATCAGGGATGACCAGAACACATTAGGACCCCAGATTATTCAAAAACTTTA
ACGAATTTTAAGGGGAAGAATTTTATCTTTTCCCTTAAAATGCAGTCATAGAAATTAGAGGATGACTCACTGCCACAGTGTCTAAAAGCA
TTTGCTAGCAAAGAGGCAGGACACTAATTTGTAAACTGCTCAACTGTTCTGACTGGAAGGGAGGCCTGGAGCTCTGCTATCACCAATCCT
TCCCTTCCCTCTACTCCACATCCTTCTAAGGAGCATGATTTGAAAATTACTTTCCTAGGTTAATGGGCATGTGCATCAATGGAGAGAATA
GTATAAGCAAGTGAGATGTAGACTAAGCAAAATTTAGATGGAGAAGCACATTTTAAAAAATTAATAACTTAAAAGTCTCAAGTTATTAAT
TTTTTTTTTGCTAACTCAATTGGAAGTAAGACTATGAAATATTTCAGTGTGTTTCCAATTCCCAGTTGAATGCAGTGTTTCAGAATTTCA
GGTATTTCTTAAGATCCTCGAAAACACTGGTGCTGTCAAGTCCAAGTTCCTCGTACAGGAATTTAATTTGGGCTGTAATCTAAAAGAAAC

>55274_55274_5_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000406134_SLC3A1_chr2_44539724_ENST00000260649_length(amino acids)=456AA_BP=181
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYD
INTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGI
DRIFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLN

--------------------------------------------------------------
>55274_55274_6_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000406134_SLC3A1_chr2_44539724_ENST00000409387_length(transcript)=1630nt_BP=707nt
AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC
AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG
GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG
CAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAG
TTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTC
AGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGAC
AGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTC
TCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAG
ACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTT
ACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAA
TGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTG
ATTCTTGCTCCGTCACCCATGCTCGAGTGCAGTGGCGTGATCTCGGCACACTGCAGCCTCTGCTTCCTGGGTTCAAGTGATTCTCCTGCT
GCAGCCTCCCAAGTAGCTGGGATTACAGGTGCACGTCATTATGCCCGGGTAATTTCTGTATTTTTTAGTAGAGATGGTGTTTCACCATGT
TGGCCAGGCTGGTCTTGAACTCCTGACCTCTGGTGATCTGTCTGCCTTGCCTCCCAAAGTGCTAGGATTACGGGCCTGAGCCACCTTGCC
TGGCCTGCAAAATTTGTTTTTAATAGAAGACACAAGAAATGATTTAAATATTTTATCAACAGAAAACCAGTTCTATCAACTATGGGCCCA
GTATGCAGCTTTTAAAAATGACAGTTCTATATACATTGATATGAGACCATTTCAAACAGGTATTCAATAAAGTATAGAATGGTAACATAT
CACCAACTGTGTAAAGAAAAATATATAAACATATGAAATGATACATTCTGTGCCTATGCAAACATATGATACATTAAAAACAAAAGAACA
TATAGTGCCTGTCTCTGAGGGGAACTGTGAAGCTATGGAAAGGTGTTGAAGAAAACCTTTTTATAGTATGTATTCTTGTAATTGAATAAA

>55274_55274_6_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000406134_SLC3A1_chr2_44539724_ENST00000409387_length(amino acids)=335AA_BP=181
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYD

--------------------------------------------------------------
>55274_55274_7_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000406134_SLC3A1_chr2_44539725_ENST00000260649_length(transcript)=2288nt_BP=707nt
AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC
AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG
GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG
CAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAG
TTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTC
AGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGAC
AGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTC
TCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAG
ACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTT
ACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAA
TGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTG
ATGTCCAAAAGACTCAGCCCAGATCGGCTTTGAAGTTATATCAAGATTTAAGTCTACTTCATGCCAATGAGCTACTCCTCAACAGGGGCT
GGTTTTGCCATTTGAGGAATGACAGCCACTATGTTGTGTACACAAGAGAGCTGGATGGCATCGACAGAATCTTTATCGTGGTTCTGAATT
TTGGAGAATCAACACTGTTAAATCTACATAATATGATTTCGGGCCTTCCCGCTAAAATGAGAATAAGGTTAAGTACCAATTCTGCCGACA
AAGGCAGTAAAGTTGATACAAGTGGCATTTTTCTGGACAAGGGAGAGGGACTCATCTTTGAACACAACACGAAGAATCTCCTTCATCGCC
AAACAGCTTTCAGAGATAGATGCTTTGTTTCCAATCGAGCATGCTATTCCAGTGTACTGAACATACTGTATACCTCGTGTTAGGCACCTT
TATGAAGAGATGAAGACACTGGCATTTCAGTGGGATTGTAAGCATTTGTAATAGCTTCATGTACAGCATGCTGCTTGGTGAACAATCATT
AATTCTTCGATATTTCTGTAGCTTGAATGTAACTGCTTTAAGAAAGGTTCTCAAATGTTTTGAAAAAAATAAAATGTTTAAAAGTAAATT
ATGGCTTATAGGAGCTTATAACTTTATTCAGATAGCATCAATCAGGGATGACCAGAACACATTAGGACCCCAGATTATTCAAAAACTTTA
ACGAATTTTAAGGGGAAGAATTTTATCTTTTCCCTTAAAATGCAGTCATAGAAATTAGAGGATGACTCACTGCCACAGTGTCTAAAAGCA
TTTGCTAGCAAAGAGGCAGGACACTAATTTGTAAACTGCTCAACTGTTCTGACTGGAAGGGAGGCCTGGAGCTCTGCTATCACCAATCCT
TCCCTTCCCTCTACTCCACATCCTTCTAAGGAGCATGATTTGAAAATTACTTTCCTAGGTTAATGGGCATGTGCATCAATGGAGAGAATA
GTATAAGCAAGTGAGATGTAGACTAAGCAAAATTTAGATGGAGAAGCACATTTTAAAAAATTAATAACTTAAAAGTCTCAAGTTATTAAT
TTTTTTTTTGCTAACTCAATTGGAAGTAAGACTATGAAATATTTCAGTGTGTTTCCAATTCCCAGTTGAATGCAGTGTTTCAGAATTTCA
GGTATTTCTTAAGATCCTCGAAAACACTGGTGCTGTCAAGTCCAAGTTCCTCGTACAGGAATTTAATTTGGGCTGTAATCTAAAAGAAAC

>55274_55274_7_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000406134_SLC3A1_chr2_44539725_ENST00000260649_length(amino acids)=456AA_BP=181
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYD
INTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGI
DRIFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLN

--------------------------------------------------------------
>55274_55274_8_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000406134_SLC3A1_chr2_44539725_ENST00000409387_length(transcript)=1630nt_BP=707nt
AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC
AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG
GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG
CAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAG
TTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTC
AGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGAC
AGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTC
TCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAG
ACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTT
ACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAA
TGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTG
ATTCTTGCTCCGTCACCCATGCTCGAGTGCAGTGGCGTGATCTCGGCACACTGCAGCCTCTGCTTCCTGGGTTCAAGTGATTCTCCTGCT
GCAGCCTCCCAAGTAGCTGGGATTACAGGTGCACGTCATTATGCCCGGGTAATTTCTGTATTTTTTAGTAGAGATGGTGTTTCACCATGT
TGGCCAGGCTGGTCTTGAACTCCTGACCTCTGGTGATCTGTCTGCCTTGCCTCCCAAAGTGCTAGGATTACGGGCCTGAGCCACCTTGCC
TGGCCTGCAAAATTTGTTTTTAATAGAAGACACAAGAAATGATTTAAATATTTTATCAACAGAAAACCAGTTCTATCAACTATGGGCCCA
GTATGCAGCTTTTAAAAATGACAGTTCTATATACATTGATATGAGACCATTTCAAACAGGTATTCAATAAAGTATAGAATGGTAACATAT
CACCAACTGTGTAAAGAAAAATATATAAACATATGAAATGATACATTCTGTGCCTATGCAAACATATGATACATTAAAAACAAAAGAACA
TATAGTGCCTGTCTCTGAGGGGAACTGTGAAGCTATGGAAAGGTGTTGAAGAAAACCTTTTTATAGTATGTATTCTTGTAATTGAATAAA

>55274_55274_8_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000406134_SLC3A1_chr2_44539725_ENST00000409387_length(amino acids)=335AA_BP=181
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYD

--------------------------------------------------------------
>55274_55274_9_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000543555_SLC3A1_chr2_44539724_ENST00000260649_length(transcript)=2167nt_BP=586nt
AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG
CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCT
TAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAA
GGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGA
TATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACA
GAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGT
TTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAA
TCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATAT
TGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTT
TTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGATGTCCAAAAGACTCAGCCCAGATCGGCTTT
GAAGTTATATCAAGATTTAAGTCTACTTCATGCCAATGAGCTACTCCTCAACAGGGGCTGGTTTTGCCATTTGAGGAATGACAGCCACTA
TGTTGTGTACACAAGAGAGCTGGATGGCATCGACAGAATCTTTATCGTGGTTCTGAATTTTGGAGAATCAACACTGTTAAATCTACATAA
TATGATTTCGGGCCTTCCCGCTAAAATGAGAATAAGGTTAAGTACCAATTCTGCCGACAAAGGCAGTAAAGTTGATACAAGTGGCATTTT
TCTGGACAAGGGAGAGGGACTCATCTTTGAACACAACACGAAGAATCTCCTTCATCGCCAAACAGCTTTCAGAGATAGATGCTTTGTTTC
CAATCGAGCATGCTATTCCAGTGTACTGAACATACTGTATACCTCGTGTTAGGCACCTTTATGAAGAGATGAAGACACTGGCATTTCAGT
GGGATTGTAAGCATTTGTAATAGCTTCATGTACAGCATGCTGCTTGGTGAACAATCATTAATTCTTCGATATTTCTGTAGCTTGAATGTA
ACTGCTTTAAGAAAGGTTCTCAAATGTTTTGAAAAAAATAAAATGTTTAAAAGTAAATTATGGCTTATAGGAGCTTATAACTTTATTCAG
ATAGCATCAATCAGGGATGACCAGAACACATTAGGACCCCAGATTATTCAAAAACTTTAACGAATTTTAAGGGGAAGAATTTTATCTTTT
CCCTTAAAATGCAGTCATAGAAATTAGAGGATGACTCACTGCCACAGTGTCTAAAAGCATTTGCTAGCAAAGAGGCAGGACACTAATTTG
TAAACTGCTCAACTGTTCTGACTGGAAGGGAGGCCTGGAGCTCTGCTATCACCAATCCTTCCCTTCCCTCTACTCCACATCCTTCTAAGG
AGCATGATTTGAAAATTACTTTCCTAGGTTAATGGGCATGTGCATCAATGGAGAGAATAGTATAAGCAAGTGAGATGTAGACTAAGCAAA
ATTTAGATGGAGAAGCACATTTTAAAAAATTAATAACTTAAAAGTCTCAAGTTATTAATTTTTTTTTTGCTAACTCAATTGGAAGTAAGA
CTATGAAATATTTCAGTGTGTTTCCAATTCCCAGTTGAATGCAGTGTTTCAGAATTTCAGGTATTTCTTAAGATCCTCGAAAACACTGGT
GCTGTCAAGTCCAAGTTCCTCGTACAGGAATTTAATTTGGGCTGTAATCTAAAAGAAACACATTAAAAAAATTAAATAGAAGGCCTTTGT

>55274_55274_9_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000543555_SLC3A1_chr2_44539724_ENST00000260649_length(amino acids)=434AA_BP=159
MGVVAVAGRRSGDVGGEAGNSLVGVGSRIFFNQEVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKAS
KENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLP
GGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQWDNSSNAGFSE
ASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGIDRIFIVVLNFGESTLLNLHNMI

--------------------------------------------------------------
>55274_55274_10_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000543555_SLC3A1_chr2_44539724_ENST00000409387_length(transcript)=1509nt_BP=586nt
AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG
CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCT
TAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAA
GGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGA
TATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACA
GAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGT
TTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAA
TCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATAT
TGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTT
TTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGATTCTTGCTCCGTCACCCATGCTCGAGTGCA
GTGGCGTGATCTCGGCACACTGCAGCCTCTGCTTCCTGGGTTCAAGTGATTCTCCTGCTGCAGCCTCCCAAGTAGCTGGGATTACAGGTG
CACGTCATTATGCCCGGGTAATTTCTGTATTTTTTAGTAGAGATGGTGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCT
GGTGATCTGTCTGCCTTGCCTCCCAAAGTGCTAGGATTACGGGCCTGAGCCACCTTGCCTGGCCTGCAAAATTTGTTTTTAATAGAAGAC
ACAAGAAATGATTTAAATATTTTATCAACAGAAAACCAGTTCTATCAACTATGGGCCCAGTATGCAGCTTTTAAAAATGACAGTTCTATA
TACATTGATATGAGACCATTTCAAACAGGTATTCAATAAAGTATAGAATGGTAACATATCACCAACTGTGTAAAGAAAAATATATAAACA
TATGAAATGATACATTCTGTGCCTATGCAAACATATGATACATTAAAAACAAAAGAACATATAGTGCCTGTCTCTGAGGGGAACTGTGAA

>55274_55274_10_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000543555_SLC3A1_chr2_44539724_ENST00000409387_length(amino acids)=313AA_BP=159
MGVVAVAGRRSGDVGGEAGNSLVGVGSRIFFNQEVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKAS
KENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLP
GGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQWDNSSNAGFSE

--------------------------------------------------------------
>55274_55274_11_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000543555_SLC3A1_chr2_44539725_ENST00000260649_length(transcript)=2167nt_BP=586nt
AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG
CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCT
TAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAA
GGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGA
TATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACA
GAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGT
TTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAA
TCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATAT
TGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTT
TTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGATGTCCAAAAGACTCAGCCCAGATCGGCTTT
GAAGTTATATCAAGATTTAAGTCTACTTCATGCCAATGAGCTACTCCTCAACAGGGGCTGGTTTTGCCATTTGAGGAATGACAGCCACTA
TGTTGTGTACACAAGAGAGCTGGATGGCATCGACAGAATCTTTATCGTGGTTCTGAATTTTGGAGAATCAACACTGTTAAATCTACATAA
TATGATTTCGGGCCTTCCCGCTAAAATGAGAATAAGGTTAAGTACCAATTCTGCCGACAAAGGCAGTAAAGTTGATACAAGTGGCATTTT
TCTGGACAAGGGAGAGGGACTCATCTTTGAACACAACACGAAGAATCTCCTTCATCGCCAAACAGCTTTCAGAGATAGATGCTTTGTTTC
CAATCGAGCATGCTATTCCAGTGTACTGAACATACTGTATACCTCGTGTTAGGCACCTTTATGAAGAGATGAAGACACTGGCATTTCAGT
GGGATTGTAAGCATTTGTAATAGCTTCATGTACAGCATGCTGCTTGGTGAACAATCATTAATTCTTCGATATTTCTGTAGCTTGAATGTA
ACTGCTTTAAGAAAGGTTCTCAAATGTTTTGAAAAAAATAAAATGTTTAAAAGTAAATTATGGCTTATAGGAGCTTATAACTTTATTCAG
ATAGCATCAATCAGGGATGACCAGAACACATTAGGACCCCAGATTATTCAAAAACTTTAACGAATTTTAAGGGGAAGAATTTTATCTTTT
CCCTTAAAATGCAGTCATAGAAATTAGAGGATGACTCACTGCCACAGTGTCTAAAAGCATTTGCTAGCAAAGAGGCAGGACACTAATTTG
TAAACTGCTCAACTGTTCTGACTGGAAGGGAGGCCTGGAGCTCTGCTATCACCAATCCTTCCCTTCCCTCTACTCCACATCCTTCTAAGG
AGCATGATTTGAAAATTACTTTCCTAGGTTAATGGGCATGTGCATCAATGGAGAGAATAGTATAAGCAAGTGAGATGTAGACTAAGCAAA
ATTTAGATGGAGAAGCACATTTTAAAAAATTAATAACTTAAAAGTCTCAAGTTATTAATTTTTTTTTTGCTAACTCAATTGGAAGTAAGA
CTATGAAATATTTCAGTGTGTTTCCAATTCCCAGTTGAATGCAGTGTTTCAGAATTTCAGGTATTTCTTAAGATCCTCGAAAACACTGGT
GCTGTCAAGTCCAAGTTCCTCGTACAGGAATTTAATTTGGGCTGTAATCTAAAAGAAACACATTAAAAAAATTAAATAGAAGGCCTTTGT

>55274_55274_11_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000543555_SLC3A1_chr2_44539725_ENST00000260649_length(amino acids)=434AA_BP=159
MGVVAVAGRRSGDVGGEAGNSLVGVGSRIFFNQEVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKAS
KENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLP
GGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQWDNSSNAGFSE
ASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGIDRIFIVVLNFGESTLLNLHNMI

--------------------------------------------------------------
>55274_55274_12_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000543555_SLC3A1_chr2_44539725_ENST00000409387_length(transcript)=1509nt_BP=586nt
AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG
CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCT
TAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAA
GGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGA
TATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACA
GAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGT
TTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAA
TCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATAT
TGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTT
TTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGATTCTTGCTCCGTCACCCATGCTCGAGTGCA
GTGGCGTGATCTCGGCACACTGCAGCCTCTGCTTCCTGGGTTCAAGTGATTCTCCTGCTGCAGCCTCCCAAGTAGCTGGGATTACAGGTG
CACGTCATTATGCCCGGGTAATTTCTGTATTTTTTAGTAGAGATGGTGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCT
GGTGATCTGTCTGCCTTGCCTCCCAAAGTGCTAGGATTACGGGCCTGAGCCACCTTGCCTGGCCTGCAAAATTTGTTTTTAATAGAAGAC
ACAAGAAATGATTTAAATATTTTATCAACAGAAAACCAGTTCTATCAACTATGGGCCCAGTATGCAGCTTTTAAAAATGACAGTTCTATA
TACATTGATATGAGACCATTTCAAACAGGTATTCAATAAAGTATAGAATGGTAACATATCACCAACTGTGTAAAGAAAAATATATAAACA
TATGAAATGATACATTCTGTGCCTATGCAAACATATGATACATTAAAAACAAAAGAACATATAGTGCCTGTCTCTGAGGGGAACTGTGAA

>55274_55274_12_MSH2-SLC3A1_MSH2_chr2_47637511_ENST00000543555_SLC3A1_chr2_44539725_ENST00000409387_length(amino acids)=313AA_BP=159
MGVVAVAGRRSGDVGGEAGNSLVGVGSRIFFNQEVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKAS
KENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLP
GGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQWDNSSNAGFSE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MSH2-SLC3A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMSH2chr2:47637511chr2:44539724ENST00000233146+316601_671215.0935.0EXO1
HgeneMSH2chr2:47637511chr2:44539724ENST00000543555+417601_671149.0869.0EXO1
HgeneMSH2chr2:47637511chr2:44539725ENST00000233146+316601_671215.0935.0EXO1
HgeneMSH2chr2:47637511chr2:44539725ENST00000543555+417601_671149.0869.0EXO1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MSH2-SLC3A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MSH2-SLC3A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMSH2C2936783Colorectal cancer, hereditary nonpolyposis, type 155GENOMICS_ENGLAND;UNIPROT
HgeneMSH2C0265325Turcot syndrome (disorder)14CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneMSH2C1333990Hereditary Nonpolyposis Colorectal Cancer11CLINGEN;CTD_human;ORPHANET
HgeneMSH2C4321324Constitutional Mismatch Repair Deficiency Syndrome10CLINGEN
HgeneMSH2C4552100Lynch Syndrome10CLINGEN;CTD_human;GENOMICS_ENGLAND
HgeneMSH2C0009405Hereditary Nonpolyposis Colorectal Neoplasms9CLINGEN;CTD_human
HgeneMSH2C1112155Hereditary non-polyposis colorectal cancer syndrome7CLINGEN;ORPHANET
HgeneMSH2C0009402Colorectal Carcinoma5CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneMSH2C1321489Torre-Muir syndrome4CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneMSH2C0346153Breast Cancer, Familial2CLINGEN
HgeneMSH2C0009404Colorectal Neoplasms1CTD_human
HgeneMSH2C0919267ovarian neoplasm1CGI;CTD_human
HgeneMSH2C1140680Malignant neoplasm of ovary1CGI;CTD_human;GENOMICS_ENGLAND
HgeneMSH2C2931459Lynch syndrome I (site-specific colonic cancer)1CTD_human
HgeneMSH2C4733333familial non-medullary thyroid cancer1GENOMICS_ENGLAND
TgeneC0010691Cystinuria20CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC1848030Hypotonia-Cystinuria Syndrome2CTD_human;ORPHANET
TgeneC1857388Cystinuria, Type A1ORPHANET
TgeneC43045372p21 microdeletion syndrome1ORPHANET