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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:ASPH-KCTD3 (FusionGDB2 ID:HG444TG51133)

Fusion Gene Summary for ASPH-KCTD3

check button Fusion gene summary
Fusion gene informationFusion gene name: ASPH-KCTD3
Fusion gene ID: hg444tg51133
HgeneTgene
Gene symbol

ASPH

KCTD3

Gene ID

444

51133

Gene nameaspartate beta-hydroxylasepotassium channel tetramerization domain containing 3
SynonymsAAH|BAH|CASQ2BP1|FDLAB|HAAH|JCTN|junctinNY-REN-45
Cytomap('ASPH')('KCTD3')

8q12.3

1q41

Type of geneprotein-codingprotein-coding
Descriptionaspartyl/asparaginyl beta-hydroxylaseA beta H-J-JASP beta-hydroxylasecardiac junctinhumbugjunctatepeptide-aspartate beta-dioxygenaseBTB/POZ domain-containing protein KCTD3NY-REN-45 antigenpotassium channel tetramerisation domain containing 3renal carcinoma antigen NY-REN-45
Modification date2020031520200313
UniProtAcc.

Q9Y597

Ensembl transtripts involved in fusion geneENST00000356457, ENST00000379454, 
ENST00000445642, ENST00000517847, 
ENST00000517903, ENST00000518068, 
ENST00000522835, ENST00000541428, 
ENST00000379449, ENST00000389204, 
ENST00000517661, ENST00000517856, 
ENST00000522603, ENST00000522919, 
ENST00000523897, 
Fusion gene scores* DoF score20 X 16 X 7=22407 X 7 X 6=294
# samples 217
** MAII scorelog2(21/2240*10)=-3.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASPH [Title/Abstract] AND KCTD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASPH(62563609)-KCTD3(215768698), # samples:1
Anticipated loss of major functional domain due to fusion event.ASPH-KCTD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASPH-KCTD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASPH-KCTD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ASPH-KCTD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASPH

GO:0045862

positive regulation of proteolysis

18387192

HgeneASPH

GO:0097202

activation of cysteine-type endopeptidase activity

18387192


check buttonFusion gene breakpoints across ASPH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across KCTD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01AASPHchr8

62563609

-KCTD3chr1

215768698

+


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Fusion Gene ORF analysis for ASPH-KCTD3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000356457ENST00000495537ASPHchr8

62563609

-KCTD3chr1

215768698

+
5CDS-intronENST00000379454ENST00000495537ASPHchr8

62563609

-KCTD3chr1

215768698

+
5CDS-intronENST00000445642ENST00000495537ASPHchr8

62563609

-KCTD3chr1

215768698

+
5CDS-intronENST00000517847ENST00000495537ASPHchr8

62563609

-KCTD3chr1

215768698

+
5CDS-intronENST00000517903ENST00000495537ASPHchr8

62563609

-KCTD3chr1

215768698

+
5CDS-intronENST00000518068ENST00000495537ASPHchr8

62563609

-KCTD3chr1

215768698

+
5CDS-intronENST00000522835ENST00000495537ASPHchr8

62563609

-KCTD3chr1

215768698

+
5CDS-intronENST00000541428ENST00000495537ASPHchr8

62563609

-KCTD3chr1

215768698

+
In-frameENST00000356457ENST00000259154ASPHchr8

62563609

-KCTD3chr1

215768698

+
In-frameENST00000379454ENST00000259154ASPHchr8

62563609

-KCTD3chr1

215768698

+
In-frameENST00000445642ENST00000259154ASPHchr8

62563609

-KCTD3chr1

215768698

+
In-frameENST00000517847ENST00000259154ASPHchr8

62563609

-KCTD3chr1

215768698

+
In-frameENST00000517903ENST00000259154ASPHchr8

62563609

-KCTD3chr1

215768698

+
In-frameENST00000518068ENST00000259154ASPHchr8

62563609

-KCTD3chr1

215768698

+
In-frameENST00000522835ENST00000259154ASPHchr8

62563609

-KCTD3chr1

215768698

+
In-frameENST00000541428ENST00000259154ASPHchr8

62563609

-KCTD3chr1

215768698

+
intron-3CDSENST00000379449ENST00000259154ASPHchr8

62563609

-KCTD3chr1

215768698

+
intron-3CDSENST00000389204ENST00000259154ASPHchr8

62563609

-KCTD3chr1

215768698

+
intron-3CDSENST00000517661ENST00000259154ASPHchr8

62563609

-KCTD3chr1

215768698

+
intron-3CDSENST00000517856ENST00000259154ASPHchr8

62563609

-KCTD3chr1

215768698

+
intron-3CDSENST00000522603ENST00000259154ASPHchr8

62563609

-KCTD3chr1

215768698

+
intron-3CDSENST00000522919ENST00000259154ASPHchr8

62563609

-KCTD3chr1

215768698

+
intron-3CDSENST00000523897ENST00000259154ASPHchr8

62563609

-KCTD3chr1

215768698

+
intron-intronENST00000379449ENST00000495537ASPHchr8

62563609

-KCTD3chr1

215768698

+
intron-intronENST00000389204ENST00000495537ASPHchr8

62563609

-KCTD3chr1

215768698

+
intron-intronENST00000517661ENST00000495537ASPHchr8

62563609

-KCTD3chr1

215768698

+
intron-intronENST00000517856ENST00000495537ASPHchr8

62563609

-KCTD3chr1

215768698

+
intron-intronENST00000522603ENST00000495537ASPHchr8

62563609

-KCTD3chr1

215768698

+
intron-intronENST00000522919ENST00000495537ASPHchr8

62563609

-KCTD3chr1

215768698

+
intron-intronENST00000523897ENST00000495537ASPHchr8

62563609

-KCTD3chr1

215768698

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000541428ASPHchr862563609-ENST00000259154KCTD3chr1215768698+33845641162194692
ENST00000379454ASPHchr862563609-ENST00000259154KCTD3chr1215768698+34986781432308721
ENST00000356457ASPHchr862563609-ENST00000259154KCTD3chr1215768698+35357151802345721
ENST00000518068ASPHchr862563609-ENST00000259154KCTD3chr1215768698+35076871522317721
ENST00000517903ASPHchr862563609-ENST00000259154KCTD3chr1215768698+3359539462169707
ENST00000445642ASPHchr862563609-ENST00000259154KCTD3chr1215768698+3348528352158707
ENST00000517847ASPHchr862563609-ENST00000259154KCTD3chr1215768698+3348528352158707
ENST00000522835ASPHchr862563609-ENST00000259154KCTD3chr1215768698+3392572792202707

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541428ENST00000259154ASPHchr862563609-KCTD3chr1215768698+0.0004363630.99956363
ENST00000379454ENST00000259154ASPHchr862563609-KCTD3chr1215768698+0.0006374230.99936265
ENST00000356457ENST00000259154ASPHchr862563609-KCTD3chr1215768698+0.0005982580.9994017
ENST00000518068ENST00000259154ASPHchr862563609-KCTD3chr1215768698+0.0006222230.9993777
ENST00000517903ENST00000259154ASPHchr862563609-KCTD3chr1215768698+0.0001796720.9998204
ENST00000445642ENST00000259154ASPHchr862563609-KCTD3chr1215768698+0.0001832740.9998167
ENST00000517847ENST00000259154ASPHchr862563609-KCTD3chr1215768698+0.0001832740.9998167
ENST00000522835ENST00000259154ASPHchr862563609-KCTD3chr1215768698+0.0001875820.9998124

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Fusion Genomic Features for ASPH-KCTD3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ASPHchr862563608-KCTD3chr1215768697+2.01E-050.99997985
ASPHchr862563608-KCTD3chr1215768697+2.01E-050.99997985

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ASPH-KCTD3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:62563609/chr1:215768698)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KCTD3

Q9Y597

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASPHchr8:62563609chr1:215768698ENST00000356457-51490_102163314.0Calcium bindingOntology_term=ECO:0000305
HgeneASPHchr8:62563609chr1:215768698ENST00000379454-52590_102163759.0Calcium bindingOntology_term=ECO:0000305
HgeneASPHchr8:62563609chr1:215768698ENST00000445642-61690_102149651.6666666666666Calcium bindingOntology_term=ECO:0000305
HgeneASPHchr8:62563609chr1:215768698ENST00000517847-61590_102149300.0Calcium bindingOntology_term=ECO:0000305
HgeneASPHchr8:62563609chr1:215768698ENST00000517903-61590_102149299.0Calcium bindingOntology_term=ECO:0000305
HgeneASPHchr8:62563609chr1:215768698ENST00000518068-51390_102163271.0Calcium bindingOntology_term=ECO:0000305
HgeneASPHchr8:62563609chr1:215768698ENST00000522835-61490_102149257.0Calcium bindingOntology_term=ECO:0000305
HgeneASPHchr8:62563609chr1:215768698ENST00000541428-52590_102134730.0Calcium bindingOntology_term=ECO:0000305
HgeneASPHchr8:62563609chr1:215768698ENST00000356457-5149_29163314.0Compositional biasNote=Ser-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000379454-5259_29163759.0Compositional biasNote=Ser-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000445642-6169_29149651.6666666666666Compositional biasNote=Ser-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000517847-6159_29149300.0Compositional biasNote=Ser-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000517903-6159_29149299.0Compositional biasNote=Ser-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000518068-5139_29163271.0Compositional biasNote=Ser-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000522835-6149_29149257.0Compositional biasNote=Ser-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000541428-5259_29134730.0Compositional biasNote=Ser-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000356457-5141_53163314.0Topological domainCytoplasmic
HgeneASPHchr8:62563609chr1:215768698ENST00000379454-5251_53163759.0Topological domainCytoplasmic
HgeneASPHchr8:62563609chr1:215768698ENST00000445642-6161_53149651.6666666666666Topological domainCytoplasmic
HgeneASPHchr8:62563609chr1:215768698ENST00000517847-6151_53149300.0Topological domainCytoplasmic
HgeneASPHchr8:62563609chr1:215768698ENST00000517903-6151_53149299.0Topological domainCytoplasmic
HgeneASPHchr8:62563609chr1:215768698ENST00000518068-5131_53163271.0Topological domainCytoplasmic
HgeneASPHchr8:62563609chr1:215768698ENST00000522835-6141_53149257.0Topological domainCytoplasmic
HgeneASPHchr8:62563609chr1:215768698ENST00000541428-5251_53134730.0Topological domainCytoplasmic
HgeneASPHchr8:62563609chr1:215768698ENST00000356457-51454_74163314.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneASPHchr8:62563609chr1:215768698ENST00000379454-52554_74163759.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneASPHchr8:62563609chr1:215768698ENST00000445642-61654_74149651.6666666666666TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneASPHchr8:62563609chr1:215768698ENST00000517847-61554_74149300.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneASPHchr8:62563609chr1:215768698ENST00000517903-61554_74149299.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneASPHchr8:62563609chr1:215768698ENST00000518068-51354_74163271.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneASPHchr8:62563609chr1:215768698ENST00000522835-61454_74149257.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneASPHchr8:62563609chr1:215768698ENST00000541428-52554_74134730.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneKCTD3chr8:62563609chr1:215768698ENST00000259154818270_305272816.0RepeatNote=WD 3
TgeneKCTD3chr8:62563609chr1:215768698ENST00000259154818310_342272816.0RepeatNote=WD 4
TgeneKCTD3chr8:62563609chr1:215768698ENST00000259154818354_404272816.0RepeatNote=WD 5
TgeneKCTD3chr8:62563609chr1:215768698ENST00000259154818412_449272816.0RepeatNote=WD 6
TgeneKCTD3chr8:62563609chr1:215768698ENST00000259154818457_504272816.0RepeatNote=WD 7
TgeneKCTD3chr8:62563609chr1:215768698ENST00000259154818510_569272816.0RepeatNote=WD 8

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASPHchr8:62563609chr1:215768698ENST00000379449-1590_1020204.0Calcium bindingOntology_term=ECO:0000305
HgeneASPHchr8:62563609chr1:215768698ENST00000389204-1690_1020226.0Calcium bindingOntology_term=ECO:0000305
HgeneASPHchr8:62563609chr1:215768698ENST00000522603-1590_1020211.0Calcium bindingOntology_term=ECO:0000305
HgeneASPHchr8:62563609chr1:215768698ENST00000356457-514111_312163314.0Compositional biasNote=Glu-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000356457-514323_332163314.0Compositional biasNote=Poly-Lys
HgeneASPHchr8:62563609chr1:215768698ENST00000379449-15111_3120204.0Compositional biasNote=Glu-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000379449-15323_3320204.0Compositional biasNote=Poly-Lys
HgeneASPHchr8:62563609chr1:215768698ENST00000379449-159_290204.0Compositional biasNote=Ser-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000379454-525111_312163759.0Compositional biasNote=Glu-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000379454-525323_332163759.0Compositional biasNote=Poly-Lys
HgeneASPHchr8:62563609chr1:215768698ENST00000389204-16111_3120226.0Compositional biasNote=Glu-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000389204-16323_3320226.0Compositional biasNote=Poly-Lys
HgeneASPHchr8:62563609chr1:215768698ENST00000389204-169_290226.0Compositional biasNote=Ser-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000445642-616111_312149651.6666666666666Compositional biasNote=Glu-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000445642-616323_332149651.6666666666666Compositional biasNote=Poly-Lys
HgeneASPHchr8:62563609chr1:215768698ENST00000517847-615111_312149300.0Compositional biasNote=Glu-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000517847-615323_332149300.0Compositional biasNote=Poly-Lys
HgeneASPHchr8:62563609chr1:215768698ENST00000517903-615111_312149299.0Compositional biasNote=Glu-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000517903-615323_332149299.0Compositional biasNote=Poly-Lys
HgeneASPHchr8:62563609chr1:215768698ENST00000518068-513111_312163271.0Compositional biasNote=Glu-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000518068-513323_332163271.0Compositional biasNote=Poly-Lys
HgeneASPHchr8:62563609chr1:215768698ENST00000522603-15111_3120211.0Compositional biasNote=Glu-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000522603-15323_3320211.0Compositional biasNote=Poly-Lys
HgeneASPHchr8:62563609chr1:215768698ENST00000522603-159_290211.0Compositional biasNote=Ser-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000522835-614111_312149257.0Compositional biasNote=Glu-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000522835-614323_332149257.0Compositional biasNote=Poly-Lys
HgeneASPHchr8:62563609chr1:215768698ENST00000541428-525111_312134730.0Compositional biasNote=Glu-rich
HgeneASPHchr8:62563609chr1:215768698ENST00000541428-525323_332134730.0Compositional biasNote=Poly-Lys
HgeneASPHchr8:62563609chr1:215768698ENST00000356457-514688_690163314.0Region2-oxoglutarate binding
HgeneASPHchr8:62563609chr1:215768698ENST00000379449-15688_6900204.0Region2-oxoglutarate binding
HgeneASPHchr8:62563609chr1:215768698ENST00000379454-525688_690163759.0Region2-oxoglutarate binding
HgeneASPHchr8:62563609chr1:215768698ENST00000389204-16688_6900226.0Region2-oxoglutarate binding
HgeneASPHchr8:62563609chr1:215768698ENST00000445642-616688_690149651.6666666666666Region2-oxoglutarate binding
HgeneASPHchr8:62563609chr1:215768698ENST00000517847-615688_690149300.0Region2-oxoglutarate binding
HgeneASPHchr8:62563609chr1:215768698ENST00000517903-615688_690149299.0Region2-oxoglutarate binding
HgeneASPHchr8:62563609chr1:215768698ENST00000518068-513688_690163271.0Region2-oxoglutarate binding
HgeneASPHchr8:62563609chr1:215768698ENST00000522603-15688_6900211.0Region2-oxoglutarate binding
HgeneASPHchr8:62563609chr1:215768698ENST00000522835-614688_690149257.0Region2-oxoglutarate binding
HgeneASPHchr8:62563609chr1:215768698ENST00000541428-525688_690134730.0Region2-oxoglutarate binding
HgeneASPHchr8:62563609chr1:215768698ENST00000356457-514341_374163314.0RepeatNote=TPR 1
HgeneASPHchr8:62563609chr1:215768698ENST00000356457-514454_487163314.0RepeatNote=TPR 2
HgeneASPHchr8:62563609chr1:215768698ENST00000356457-514489_521163314.0RepeatNote=TPR 3
HgeneASPHchr8:62563609chr1:215768698ENST00000356457-514525_557163314.0RepeatNote=TPR 4
HgeneASPHchr8:62563609chr1:215768698ENST00000379449-15341_3740204.0RepeatNote=TPR 1
HgeneASPHchr8:62563609chr1:215768698ENST00000379449-15454_4870204.0RepeatNote=TPR 2
HgeneASPHchr8:62563609chr1:215768698ENST00000379449-15489_5210204.0RepeatNote=TPR 3
HgeneASPHchr8:62563609chr1:215768698ENST00000379449-15525_5570204.0RepeatNote=TPR 4
HgeneASPHchr8:62563609chr1:215768698ENST00000379454-525341_374163759.0RepeatNote=TPR 1
HgeneASPHchr8:62563609chr1:215768698ENST00000379454-525454_487163759.0RepeatNote=TPR 2
HgeneASPHchr8:62563609chr1:215768698ENST00000379454-525489_521163759.0RepeatNote=TPR 3
HgeneASPHchr8:62563609chr1:215768698ENST00000379454-525525_557163759.0RepeatNote=TPR 4
HgeneASPHchr8:62563609chr1:215768698ENST00000389204-16341_3740226.0RepeatNote=TPR 1
HgeneASPHchr8:62563609chr1:215768698ENST00000389204-16454_4870226.0RepeatNote=TPR 2
HgeneASPHchr8:62563609chr1:215768698ENST00000389204-16489_5210226.0RepeatNote=TPR 3
HgeneASPHchr8:62563609chr1:215768698ENST00000389204-16525_5570226.0RepeatNote=TPR 4
HgeneASPHchr8:62563609chr1:215768698ENST00000445642-616341_374149651.6666666666666RepeatNote=TPR 1
HgeneASPHchr8:62563609chr1:215768698ENST00000445642-616454_487149651.6666666666666RepeatNote=TPR 2
HgeneASPHchr8:62563609chr1:215768698ENST00000445642-616489_521149651.6666666666666RepeatNote=TPR 3
HgeneASPHchr8:62563609chr1:215768698ENST00000445642-616525_557149651.6666666666666RepeatNote=TPR 4
HgeneASPHchr8:62563609chr1:215768698ENST00000517847-615341_374149300.0RepeatNote=TPR 1
HgeneASPHchr8:62563609chr1:215768698ENST00000517847-615454_487149300.0RepeatNote=TPR 2
HgeneASPHchr8:62563609chr1:215768698ENST00000517847-615489_521149300.0RepeatNote=TPR 3
HgeneASPHchr8:62563609chr1:215768698ENST00000517847-615525_557149300.0RepeatNote=TPR 4
HgeneASPHchr8:62563609chr1:215768698ENST00000517903-615341_374149299.0RepeatNote=TPR 1
HgeneASPHchr8:62563609chr1:215768698ENST00000517903-615454_487149299.0RepeatNote=TPR 2
HgeneASPHchr8:62563609chr1:215768698ENST00000517903-615489_521149299.0RepeatNote=TPR 3
HgeneASPHchr8:62563609chr1:215768698ENST00000517903-615525_557149299.0RepeatNote=TPR 4
HgeneASPHchr8:62563609chr1:215768698ENST00000518068-513341_374163271.0RepeatNote=TPR 1
HgeneASPHchr8:62563609chr1:215768698ENST00000518068-513454_487163271.0RepeatNote=TPR 2
HgeneASPHchr8:62563609chr1:215768698ENST00000518068-513489_521163271.0RepeatNote=TPR 3
HgeneASPHchr8:62563609chr1:215768698ENST00000518068-513525_557163271.0RepeatNote=TPR 4
HgeneASPHchr8:62563609chr1:215768698ENST00000522603-15341_3740211.0RepeatNote=TPR 1
HgeneASPHchr8:62563609chr1:215768698ENST00000522603-15454_4870211.0RepeatNote=TPR 2
HgeneASPHchr8:62563609chr1:215768698ENST00000522603-15489_5210211.0RepeatNote=TPR 3
HgeneASPHchr8:62563609chr1:215768698ENST00000522603-15525_5570211.0RepeatNote=TPR 4
HgeneASPHchr8:62563609chr1:215768698ENST00000522835-614341_374149257.0RepeatNote=TPR 1
HgeneASPHchr8:62563609chr1:215768698ENST00000522835-614454_487149257.0RepeatNote=TPR 2
HgeneASPHchr8:62563609chr1:215768698ENST00000522835-614489_521149257.0RepeatNote=TPR 3
HgeneASPHchr8:62563609chr1:215768698ENST00000522835-614525_557149257.0RepeatNote=TPR 4
HgeneASPHchr8:62563609chr1:215768698ENST00000541428-525341_374134730.0RepeatNote=TPR 1
HgeneASPHchr8:62563609chr1:215768698ENST00000541428-525454_487134730.0RepeatNote=TPR 2
HgeneASPHchr8:62563609chr1:215768698ENST00000541428-525489_521134730.0RepeatNote=TPR 3
HgeneASPHchr8:62563609chr1:215768698ENST00000541428-525525_557134730.0RepeatNote=TPR 4
HgeneASPHchr8:62563609chr1:215768698ENST00000356457-51475_758163314.0Topological domainLumenal
HgeneASPHchr8:62563609chr1:215768698ENST00000379449-151_530204.0Topological domainCytoplasmic
HgeneASPHchr8:62563609chr1:215768698ENST00000379449-1575_7580204.0Topological domainLumenal
HgeneASPHchr8:62563609chr1:215768698ENST00000379454-52575_758163759.0Topological domainLumenal
HgeneASPHchr8:62563609chr1:215768698ENST00000389204-161_530226.0Topological domainCytoplasmic
HgeneASPHchr8:62563609chr1:215768698ENST00000389204-1675_7580226.0Topological domainLumenal
HgeneASPHchr8:62563609chr1:215768698ENST00000445642-61675_758149651.6666666666666Topological domainLumenal
HgeneASPHchr8:62563609chr1:215768698ENST00000517847-61575_758149300.0Topological domainLumenal
HgeneASPHchr8:62563609chr1:215768698ENST00000517903-61575_758149299.0Topological domainLumenal
HgeneASPHchr8:62563609chr1:215768698ENST00000518068-51375_758163271.0Topological domainLumenal
HgeneASPHchr8:62563609chr1:215768698ENST00000522603-151_530211.0Topological domainCytoplasmic
HgeneASPHchr8:62563609chr1:215768698ENST00000522603-1575_7580211.0Topological domainLumenal
HgeneASPHchr8:62563609chr1:215768698ENST00000522835-61475_758149257.0Topological domainLumenal
HgeneASPHchr8:62563609chr1:215768698ENST00000541428-52575_758134730.0Topological domainLumenal
HgeneASPHchr8:62563609chr1:215768698ENST00000379449-1554_740204.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneASPHchr8:62563609chr1:215768698ENST00000389204-1654_740226.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneASPHchr8:62563609chr1:215768698ENST00000522603-1554_740211.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneKCTD3chr8:62563609chr1:215768698ENST0000025915481818_87272816.0DomainBTB
TgeneKCTD3chr8:62563609chr1:215768698ENST00000259154818174_218272816.0RepeatNote=WD 1
TgeneKCTD3chr8:62563609chr1:215768698ENST00000259154818224_263272816.0RepeatNote=WD 2


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Fusion Gene Sequence for ASPH-KCTD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7208_7208_1_ASPH-KCTD3_ASPH_chr8_62563609_ENST00000356457_KCTD3_chr1_215768698_ENST00000259154_length(transcript)=3535nt_BP=715nt
AGGGAGTCACAGGTTCGTACACGCGAGGCCGGGCGCGCGCAGCCGGCAGGCGGGTGAAGTCTTCCCAGGTGCTGCAGGCGGTGCTGAGGC
ACAGGGTCTGCTGCAGGAGCAGCGGCCCGAACCCGCTCCAGCGGCCCGCCGCCGCCAGCGGTTCCCGCGTCGCGTGTGTACCCCCGCGCA
CTGAAGGAGGTCCGCCAGCCCTCACCAGCCCCCGCGGACCGTGCAATGGCCCAGCGTAAGAATGCCAAGAGCAGCGGCAACAGCAGCAGC
AGCGGCTCCGGCAGCGGTAGCACGAGTGCGGGCAGCAGCAGCCCCGGGGCCCGGAGAGAGACAAAGCATGGAGGACACAAGAATGGGAGG
AAAGGCGGACTCTCAGGAACTTCATTCTTCACGTGGTTTATGGTGATTGCATTGCTGGGCGTCTGGACATCTGTAGCTGTCGTTTGGTTT
GATCTTGTTGACTATGAGGAAGTTCTAGGAAAACTAGGAATCTATGATGCTGATGGTGATGGAGATTTTGATGTGGATGATGCCAAAGTT
TTATTAGGACTTAAAGAGAGATCTACTTCAGAGCCAGCAGTCCCGCCAGAAGAGGCTGAGCCACACACTGAGCCCGAGGAGCAGGTTCCT
GTGGAGGCAGAACCCCAGAATATCGAAGATGAAGCAAAAGAACAAATTCAGTCCCTTCTCCATGAAATGGTACACGCAGAACATGGAGTG
TTCAGCCTGGGTGTTCCTGTAGATGCTCTCTTCTTTATTGGTAACCAGTTGGTGGCCACGAGTCATACAGGGAAAGTGGGAGTGTGGAAT
GCTGTCACTCAGCACTGGCAGGTTCAAGATGTTGTTCCTATAACTAGTTATGACACTGCTGGATCATTCCTTCTGCTTGGATGTAACAAT
GGATCAATATATTACATAGATATGCAGAAGTTCCCCTTGCGAATGAAAGATAATGATCTTCTTGTAACTGAACTGTATCATGATCCTTCA
AATGATGCTATTACTGCTCTGAGTGTTTACCTCACACCCAAAACAAGTGTCAGTGGTAACTGGATCGAGATCGCCTATGGTACGAGCTCT
GGAGCAGTACGAGTGATTGTACAACACCCAGAGACAGTTGGGTCAGGTCCTCAGCTTTTTCAGACTTTCACAGTTCACCGAAGTCCCGTA
ACAAAAATCATGCTATCAGAGAAGCATCTTGTATCAGTCTGTGCAGATAATAATCATGTCCGGACGTGGACAGTAACACGATTCAGAGGA
ATGATCTCTACTCAGCCAGGTTCTACTCCTTTAGCGTCATTCAAGATACTATCCCTGGAGGAGACAGAAAGTCATGGTAGCTATTCCTCT
GGAAATGACATAGGACCTTTTGGAGAGCGAGACGATCAACAGGTGTTTATCCAGAAAGTTGTTCCCATCACCAACAAACTATTTGTAAGA
CTCTCATCGACTGGAAAAAGAATATGTGAGATCCAGGCTGTTGACTGTACTACAATATCCTCATTTACAGTGAGGGAATGTGAGGGATCC
AGTAGGATGGGCTCAAGACCAAGGCGCTACTTGTTCACAGGCCATACAAATGGCAGTATTCAAATGTGGGATCTGACCACTGCTATGGAT
ATGGTTAACAAAAGTGAAGATAAGGATGTAGGTGGTCCAACCGAAGAAGAGCTACTCAAATTACTCGATCAATGTGATTTGAGCACATCT
CGCTGTGCTACTCCTAACATCAGTCCAGCAACTTCCGTAGTTCAGCATAGCCACTTACGAGAATCAAATTCTAGCCTTCAGCTTCAGCAC
CATGATACCACCCATGAAGCAGCTACTTACGGTTCCATGAGGCCTTACAGAGAAAGTCCTTTATTAGCAAGGGCAAGAAGGACTGAGAGC
TTTCACAGTTATAGGGACTTCCAGACTATTAATTTGAACAGAAATGTAGAAAGAGCTGTCCCTGAAAATGGTAACTTGGGTCCAATACAA
GCTGAAGTGAAAGGGGCAACAGGGGAATGTAATATATCTGAGAGAAAGTCTCCTGGAGTAGAAATAAAAAGTTTGAGAGAATTGGATAGT
GGATTGGAAGTGCATAAAATAGCTGAAGGTTTTTCAGAATCCAAGAAAAGGTCATCAGAAGATGAAAATGAAAATAAAATAGAGTTTAGG
AAGAAAGGAGGATTTGAAGGGGGAGGATTCCTTGGAAGAAAGAAAGTTCCCTATCTGGCGTCATCACCAAGTACTTCCGATGGAGGAACT
GACTCACCTGGTACTGCGTCCCCATCTCCTACAAAGACTACTCCATCTCCTCGGCATAAAAAAAGTGATTCTTCAGGTCAGGAGTACAGC
TTGTGAAAACTCACCAAAATGAATAGTTGTTTCGTTACATTTAGATGAAAGTTAAACTTTACTGAATTTCAGTACATTAGTTTTTACACT
AAAACTTTACAAGATAAAATTGGACTTCATTTAGTATCTTTTTAACAGAATTACTTGGAATAATGAGATACAATAATCATATCTCTTTTG
ACATTTTGGAAATTTTTTTAATTTTACAAGTACATTTAACAGATCATTTATAAAGCAGGAGTCCATTTTAACACTTACCGACTTTTTTTG
GTTTGGAAACATATTACCACGTCTTAATAGGATGGTGCCCATATAGGTGAGCATCCCTTTAGATCATGGGAACCAGCAGACTGCATTCCT
AATCTTCATTATGCCTGAGACTTGTCTTACAATGTTACCTTTAAGTGAATCACATAATTGTCTTTGGAACTTGGTCTCCCAACACTTATT
GTGATTGCAAAGTGTTTACCAGATATTTGATGAGGTGCTATGTTTGTGAAAAACATATCATGTAATTCAAAAACACTATTGATATTGAAT
ACCAGATACCACTATGTAGTAAGTCTTTTAGGATGATTTTAATTTAGTCGTGCGTCATTTTCTGATTCTCATCATTGGGAGATCTTAAAT
CTTAGCAAGCATTAGCAATATTAAATGCCAAAATTCCATTGAAACTTTCAAGTTGGAGCAATTGTCTGTGTTTGAAAAGATGAAATAAAA
ATAATAATCAAGGGCAAAGCTTTGAGTGCCCAGAAGGGAAAGCTGTACCAGTTGCTAACCTGTCTTGTTTCAGGAGCCACCATGTTTTTT
TTTCAGTGTTAACAACAATCATGATAATTAAATTAAAACACTAGTTTGTTCACTTGTAGGACTGCAGTTCTGAATTTTGGGTTAAAGGTT
TTGGCTGCTGTAAGAATGTGAATTTGAATGTATTTTGAATTGTAAGAGCAAAAGAACGTTTTTGTACAATTTTTTTTCATTTAATTGGAA
TGATCTTCAGGTTTCTACAAATAGGGTAATTGTAAATTTAAAGCATTAGCATTTATTGGTGAATAATGTATATATCCCCATTCCAAGAAA
TATAAGTGAGTGAAGTTGAAATAAAATCTTTAAAATTTACTATATTGCCAGTGGTTTCACAACAGTTCTCTTGTATTTATTTATCAATTA
AATCAAATAAAAATGATTATGTCAA

>7208_7208_1_ASPH-KCTD3_ASPH_chr8_62563609_ENST00000356457_KCTD3_chr1_215768698_ENST00000259154_length(amino acids)=721AA_BP=178
MKEVRQPSPAPADRAMAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGGHKNGRKGGLSGTSFFTWFMVIALLGVWTSVAVVWF
DLVDYEEVLGKLGIYDADGDGDFDVDDAKVLLGLKERSTSEPAVPPEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHGV
FSLGVPVDALFFIGNQLVATSHTGKVGVWNAVTQHWQVQDVVPITSYDTAGSFLLLGCNNGSIYYIDMQKFPLRMKDNDLLVTELYHDPS
NDAITALSVYLTPKTSVSGNWIEIAYGTSSGAVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLVSVCADNNHVRTWTVTRFRG
MISTQPGSTPLASFKILSLEETESHGSYSSGNDIGPFGERDDQQVFIQKVVPITNKLFVRLSSTGKRICEIQAVDCTTISSFTVRECEGS
SRMGSRPRRYLFTGHTNGSIQMWDLTTAMDMVNKSEDKDVGGPTEEELLKLLDQCDLSTSRCATPNISPATSVVQHSHLRESNSSLQLQH
HDTTHEAATYGSMRPYRESPLLARARRTESFHSYRDFQTINLNRNVERAVPENGNLGPIQAEVKGATGECNISERKSPGVEIKSLRELDS
GLEVHKIAEGFSESKKRSSEDENENKIEFRKKGGFEGGGFLGRKKVPYLASSPSTSDGGTDSPGTASPSPTKTTPSPRHKKSDSSGQEYS
L

--------------------------------------------------------------
>7208_7208_2_ASPH-KCTD3_ASPH_chr8_62563609_ENST00000379454_KCTD3_chr1_215768698_ENST00000259154_length(transcript)=3498nt_BP=678nt
CGCAGCCGGCAGGCGGGTGAAGTCTTCCCAGGTGCTGCAGGCGGTGCTGAGGCACAGGGTCTGCTGCAGGAGCAGCGGCCCGAACCCGCT
CCAGCGGCCCGCCGCCGCCAGCGGTTCCCGCGTCGCGTGTGTACCCCCGCGCACTGAAGGAGGTCCGCCAGCCCTCACCAGCCCCCGCGG
ACCGTGCAATGGCCCAGCGTAAGAATGCCAAGAGCAGCGGCAACAGCAGCAGCAGCGGCTCCGGCAGCGGTAGCACGAGTGCGGGCAGCA
GCAGCCCCGGGGCCCGGAGAGAGACAAAGCATGGAGGACACAAGAATGGGAGGAAAGGCGGACTCTCAGGAACTTCATTCTTCACGTGGT
TTATGGTGATTGCATTGCTGGGCGTCTGGACATCTGTAGCTGTCGTTTGGTTTGATCTTGTTGACTATGAGGAAGTTCTAGGAAAACTAG
GAATCTATGATGCTGATGGTGATGGAGATTTTGATGTGGATGATGCCAAAGTTTTATTAGGACTTAAAGAGAGATCTACTTCAGAGCCAG
CAGTCCCGCCAGAAGAGGCTGAGCCACACACTGAGCCCGAGGAGCAGGTTCCTGTGGAGGCAGAACCCCAGAATATCGAAGATGAAGCAA
AAGAACAAATTCAGTCCCTTCTCCATGAAATGGTACACGCAGAACATGGAGTGTTCAGCCTGGGTGTTCCTGTAGATGCTCTCTTCTTTA
TTGGTAACCAGTTGGTGGCCACGAGTCATACAGGGAAAGTGGGAGTGTGGAATGCTGTCACTCAGCACTGGCAGGTTCAAGATGTTGTTC
CTATAACTAGTTATGACACTGCTGGATCATTCCTTCTGCTTGGATGTAACAATGGATCAATATATTACATAGATATGCAGAAGTTCCCCT
TGCGAATGAAAGATAATGATCTTCTTGTAACTGAACTGTATCATGATCCTTCAAATGATGCTATTACTGCTCTGAGTGTTTACCTCACAC
CCAAAACAAGTGTCAGTGGTAACTGGATCGAGATCGCCTATGGTACGAGCTCTGGAGCAGTACGAGTGATTGTACAACACCCAGAGACAG
TTGGGTCAGGTCCTCAGCTTTTTCAGACTTTCACAGTTCACCGAAGTCCCGTAACAAAAATCATGCTATCAGAGAAGCATCTTGTATCAG
TCTGTGCAGATAATAATCATGTCCGGACGTGGACAGTAACACGATTCAGAGGAATGATCTCTACTCAGCCAGGTTCTACTCCTTTAGCGT
CATTCAAGATACTATCCCTGGAGGAGACAGAAAGTCATGGTAGCTATTCCTCTGGAAATGACATAGGACCTTTTGGAGAGCGAGACGATC
AACAGGTGTTTATCCAGAAAGTTGTTCCCATCACCAACAAACTATTTGTAAGACTCTCATCGACTGGAAAAAGAATATGTGAGATCCAGG
CTGTTGACTGTACTACAATATCCTCATTTACAGTGAGGGAATGTGAGGGATCCAGTAGGATGGGCTCAAGACCAAGGCGCTACTTGTTCA
CAGGCCATACAAATGGCAGTATTCAAATGTGGGATCTGACCACTGCTATGGATATGGTTAACAAAAGTGAAGATAAGGATGTAGGTGGTC
CAACCGAAGAAGAGCTACTCAAATTACTCGATCAATGTGATTTGAGCACATCTCGCTGTGCTACTCCTAACATCAGTCCAGCAACTTCCG
TAGTTCAGCATAGCCACTTACGAGAATCAAATTCTAGCCTTCAGCTTCAGCACCATGATACCACCCATGAAGCAGCTACTTACGGTTCCA
TGAGGCCTTACAGAGAAAGTCCTTTATTAGCAAGGGCAAGAAGGACTGAGAGCTTTCACAGTTATAGGGACTTCCAGACTATTAATTTGA
ACAGAAATGTAGAAAGAGCTGTCCCTGAAAATGGTAACTTGGGTCCAATACAAGCTGAAGTGAAAGGGGCAACAGGGGAATGTAATATAT
CTGAGAGAAAGTCTCCTGGAGTAGAAATAAAAAGTTTGAGAGAATTGGATAGTGGATTGGAAGTGCATAAAATAGCTGAAGGTTTTTCAG
AATCCAAGAAAAGGTCATCAGAAGATGAAAATGAAAATAAAATAGAGTTTAGGAAGAAAGGAGGATTTGAAGGGGGAGGATTCCTTGGAA
GAAAGAAAGTTCCCTATCTGGCGTCATCACCAAGTACTTCCGATGGAGGAACTGACTCACCTGGTACTGCGTCCCCATCTCCTACAAAGA
CTACTCCATCTCCTCGGCATAAAAAAAGTGATTCTTCAGGTCAGGAGTACAGCTTGTGAAAACTCACCAAAATGAATAGTTGTTTCGTTA
CATTTAGATGAAAGTTAAACTTTACTGAATTTCAGTACATTAGTTTTTACACTAAAACTTTACAAGATAAAATTGGACTTCATTTAGTAT
CTTTTTAACAGAATTACTTGGAATAATGAGATACAATAATCATATCTCTTTTGACATTTTGGAAATTTTTTTAATTTTACAAGTACATTT
AACAGATCATTTATAAAGCAGGAGTCCATTTTAACACTTACCGACTTTTTTTGGTTTGGAAACATATTACCACGTCTTAATAGGATGGTG
CCCATATAGGTGAGCATCCCTTTAGATCATGGGAACCAGCAGACTGCATTCCTAATCTTCATTATGCCTGAGACTTGTCTTACAATGTTA
CCTTTAAGTGAATCACATAATTGTCTTTGGAACTTGGTCTCCCAACACTTATTGTGATTGCAAAGTGTTTACCAGATATTTGATGAGGTG
CTATGTTTGTGAAAAACATATCATGTAATTCAAAAACACTATTGATATTGAATACCAGATACCACTATGTAGTAAGTCTTTTAGGATGAT
TTTAATTTAGTCGTGCGTCATTTTCTGATTCTCATCATTGGGAGATCTTAAATCTTAGCAAGCATTAGCAATATTAAATGCCAAAATTCC
ATTGAAACTTTCAAGTTGGAGCAATTGTCTGTGTTTGAAAAGATGAAATAAAAATAATAATCAAGGGCAAAGCTTTGAGTGCCCAGAAGG
GAAAGCTGTACCAGTTGCTAACCTGTCTTGTTTCAGGAGCCACCATGTTTTTTTTTCAGTGTTAACAACAATCATGATAATTAAATTAAA
ACACTAGTTTGTTCACTTGTAGGACTGCAGTTCTGAATTTTGGGTTAAAGGTTTTGGCTGCTGTAAGAATGTGAATTTGAATGTATTTTG
AATTGTAAGAGCAAAAGAACGTTTTTGTACAATTTTTTTTCATTTAATTGGAATGATCTTCAGGTTTCTACAAATAGGGTAATTGTAAAT
TTAAAGCATTAGCATTTATTGGTGAATAATGTATATATCCCCATTCCAAGAAATATAAGTGAGTGAAGTTGAAATAAAATCTTTAAAATT
TACTATATTGCCAGTGGTTTCACAACAGTTCTCTTGTATTTATTTATCAATTAAATCAAATAAAAATGATTATGTCAA

>7208_7208_2_ASPH-KCTD3_ASPH_chr8_62563609_ENST00000379454_KCTD3_chr1_215768698_ENST00000259154_length(amino acids)=721AA_BP=178
MKEVRQPSPAPADRAMAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGGHKNGRKGGLSGTSFFTWFMVIALLGVWTSVAVVWF
DLVDYEEVLGKLGIYDADGDGDFDVDDAKVLLGLKERSTSEPAVPPEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHGV
FSLGVPVDALFFIGNQLVATSHTGKVGVWNAVTQHWQVQDVVPITSYDTAGSFLLLGCNNGSIYYIDMQKFPLRMKDNDLLVTELYHDPS
NDAITALSVYLTPKTSVSGNWIEIAYGTSSGAVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLVSVCADNNHVRTWTVTRFRG
MISTQPGSTPLASFKILSLEETESHGSYSSGNDIGPFGERDDQQVFIQKVVPITNKLFVRLSSTGKRICEIQAVDCTTISSFTVRECEGS
SRMGSRPRRYLFTGHTNGSIQMWDLTTAMDMVNKSEDKDVGGPTEEELLKLLDQCDLSTSRCATPNISPATSVVQHSHLRESNSSLQLQH
HDTTHEAATYGSMRPYRESPLLARARRTESFHSYRDFQTINLNRNVERAVPENGNLGPIQAEVKGATGECNISERKSPGVEIKSLRELDS
GLEVHKIAEGFSESKKRSSEDENENKIEFRKKGGFEGGGFLGRKKVPYLASSPSTSDGGTDSPGTASPSPTKTTPSPRHKKSDSSGQEYS
L

--------------------------------------------------------------
>7208_7208_3_ASPH-KCTD3_ASPH_chr8_62563609_ENST00000445642_KCTD3_chr1_215768698_ENST00000259154_length(transcript)=3348nt_BP=528nt
CCTGCCAGCAGTACTTTTGAGTTTTTTTTTTTGTTTTGTTTTACTTTAGCATTTATTATTCATGGATTGAAGAAATCAAAATGGCTGAAG
ATAAAGAGACAAAGCATGGAGGACACAAGAATGGGAGGAAAGGCGGACTCTCAGGAACTTCATTCTTCACGTGGTTTATGGTGATTGCAT
TGCTGGGCGTCTGGACATCTGTAGCTGTCGTTTGGTTTGATCTTGTTGACTATGAGGAAGTTCTAGCCAAAGCAAAGGACTTCCGTTATA
ACTTATCAGAGGTGCTTCAAGGAAAACTAGGAATCTATGATGCTGATGGTGATGGAGATTTTGATGTGGATGATGCCAAAGTTTTATTAG
GACTTAAAGAGAGATCTACTTCAGAGCCAGCAGTCCCGCCAGAAGAGGCTGAGCCACACACTGAGCCCGAGGAGCAGGTTCCTGTGGAGG
CAGAACCCCAGAATATCGAAGATGAAGCAAAAGAACAAATTCAGTCCCTTCTCCATGAAATGGTACACGCAGAACATGGAGTGTTCAGCC
TGGGTGTTCCTGTAGATGCTCTCTTCTTTATTGGTAACCAGTTGGTGGCCACGAGTCATACAGGGAAAGTGGGAGTGTGGAATGCTGTCA
CTCAGCACTGGCAGGTTCAAGATGTTGTTCCTATAACTAGTTATGACACTGCTGGATCATTCCTTCTGCTTGGATGTAACAATGGATCAA
TATATTACATAGATATGCAGAAGTTCCCCTTGCGAATGAAAGATAATGATCTTCTTGTAACTGAACTGTATCATGATCCTTCAAATGATG
CTATTACTGCTCTGAGTGTTTACCTCACACCCAAAACAAGTGTCAGTGGTAACTGGATCGAGATCGCCTATGGTACGAGCTCTGGAGCAG
TACGAGTGATTGTACAACACCCAGAGACAGTTGGGTCAGGTCCTCAGCTTTTTCAGACTTTCACAGTTCACCGAAGTCCCGTAACAAAAA
TCATGCTATCAGAGAAGCATCTTGTATCAGTCTGTGCAGATAATAATCATGTCCGGACGTGGACAGTAACACGATTCAGAGGAATGATCT
CTACTCAGCCAGGTTCTACTCCTTTAGCGTCATTCAAGATACTATCCCTGGAGGAGACAGAAAGTCATGGTAGCTATTCCTCTGGAAATG
ACATAGGACCTTTTGGAGAGCGAGACGATCAACAGGTGTTTATCCAGAAAGTTGTTCCCATCACCAACAAACTATTTGTAAGACTCTCAT
CGACTGGAAAAAGAATATGTGAGATCCAGGCTGTTGACTGTACTACAATATCCTCATTTACAGTGAGGGAATGTGAGGGATCCAGTAGGA
TGGGCTCAAGACCAAGGCGCTACTTGTTCACAGGCCATACAAATGGCAGTATTCAAATGTGGGATCTGACCACTGCTATGGATATGGTTA
ACAAAAGTGAAGATAAGGATGTAGGTGGTCCAACCGAAGAAGAGCTACTCAAATTACTCGATCAATGTGATTTGAGCACATCTCGCTGTG
CTACTCCTAACATCAGTCCAGCAACTTCCGTAGTTCAGCATAGCCACTTACGAGAATCAAATTCTAGCCTTCAGCTTCAGCACCATGATA
CCACCCATGAAGCAGCTACTTACGGTTCCATGAGGCCTTACAGAGAAAGTCCTTTATTAGCAAGGGCAAGAAGGACTGAGAGCTTTCACA
GTTATAGGGACTTCCAGACTATTAATTTGAACAGAAATGTAGAAAGAGCTGTCCCTGAAAATGGTAACTTGGGTCCAATACAAGCTGAAG
TGAAAGGGGCAACAGGGGAATGTAATATATCTGAGAGAAAGTCTCCTGGAGTAGAAATAAAAAGTTTGAGAGAATTGGATAGTGGATTGG
AAGTGCATAAAATAGCTGAAGGTTTTTCAGAATCCAAGAAAAGGTCATCAGAAGATGAAAATGAAAATAAAATAGAGTTTAGGAAGAAAG
GAGGATTTGAAGGGGGAGGATTCCTTGGAAGAAAGAAAGTTCCCTATCTGGCGTCATCACCAAGTACTTCCGATGGAGGAACTGACTCAC
CTGGTACTGCGTCCCCATCTCCTACAAAGACTACTCCATCTCCTCGGCATAAAAAAAGTGATTCTTCAGGTCAGGAGTACAGCTTGTGAA
AACTCACCAAAATGAATAGTTGTTTCGTTACATTTAGATGAAAGTTAAACTTTACTGAATTTCAGTACATTAGTTTTTACACTAAAACTT
TACAAGATAAAATTGGACTTCATTTAGTATCTTTTTAACAGAATTACTTGGAATAATGAGATACAATAATCATATCTCTTTTGACATTTT
GGAAATTTTTTTAATTTTACAAGTACATTTAACAGATCATTTATAAAGCAGGAGTCCATTTTAACACTTACCGACTTTTTTTGGTTTGGA
AACATATTACCACGTCTTAATAGGATGGTGCCCATATAGGTGAGCATCCCTTTAGATCATGGGAACCAGCAGACTGCATTCCTAATCTTC
ATTATGCCTGAGACTTGTCTTACAATGTTACCTTTAAGTGAATCACATAATTGTCTTTGGAACTTGGTCTCCCAACACTTATTGTGATTG
CAAAGTGTTTACCAGATATTTGATGAGGTGCTATGTTTGTGAAAAACATATCATGTAATTCAAAAACACTATTGATATTGAATACCAGAT
ACCACTATGTAGTAAGTCTTTTAGGATGATTTTAATTTAGTCGTGCGTCATTTTCTGATTCTCATCATTGGGAGATCTTAAATCTTAGCA
AGCATTAGCAATATTAAATGCCAAAATTCCATTGAAACTTTCAAGTTGGAGCAATTGTCTGTGTTTGAAAAGATGAAATAAAAATAATAA
TCAAGGGCAAAGCTTTGAGTGCCCAGAAGGGAAAGCTGTACCAGTTGCTAACCTGTCTTGTTTCAGGAGCCACCATGTTTTTTTTTCAGT
GTTAACAACAATCATGATAATTAAATTAAAACACTAGTTTGTTCACTTGTAGGACTGCAGTTCTGAATTTTGGGTTAAAGGTTTTGGCTG
CTGTAAGAATGTGAATTTGAATGTATTTTGAATTGTAAGAGCAAAAGAACGTTTTTGTACAATTTTTTTTCATTTAATTGGAATGATCTT
CAGGTTTCTACAAATAGGGTAATTGTAAATTTAAAGCATTAGCATTTATTGGTGAATAATGTATATATCCCCATTCCAAGAAATATAAGT
GAGTGAAGTTGAAATAAAATCTTTAAAATTTACTATATTGCCAGTGGTTTCACAACAGTTCTCTTGTATTTATTTATCAATTAAATCAAA
TAAAAATGATTATGTCAA

>7208_7208_3_ASPH-KCTD3_ASPH_chr8_62563609_ENST00000445642_KCTD3_chr1_215768698_ENST00000259154_length(amino acids)=707AA_BP=164
MFYFSIYYSWIEEIKMAEDKETKHGGHKNGRKGGLSGTSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLAKAKDFRYNLSEVLQGKLGI
YDADGDGDFDVDDAKVLLGLKERSTSEPAVPPEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHGVFSLGVPVDALFFIG
NQLVATSHTGKVGVWNAVTQHWQVQDVVPITSYDTAGSFLLLGCNNGSIYYIDMQKFPLRMKDNDLLVTELYHDPSNDAITALSVYLTPK
TSVSGNWIEIAYGTSSGAVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLVSVCADNNHVRTWTVTRFRGMISTQPGSTPLASF
KILSLEETESHGSYSSGNDIGPFGERDDQQVFIQKVVPITNKLFVRLSSTGKRICEIQAVDCTTISSFTVRECEGSSRMGSRPRRYLFTG
HTNGSIQMWDLTTAMDMVNKSEDKDVGGPTEEELLKLLDQCDLSTSRCATPNISPATSVVQHSHLRESNSSLQLQHHDTTHEAATYGSMR
PYRESPLLARARRTESFHSYRDFQTINLNRNVERAVPENGNLGPIQAEVKGATGECNISERKSPGVEIKSLRELDSGLEVHKIAEGFSES
KKRSSEDENENKIEFRKKGGFEGGGFLGRKKVPYLASSPSTSDGGTDSPGTASPSPTKTTPSPRHKKSDSSGQEYSL

--------------------------------------------------------------
>7208_7208_4_ASPH-KCTD3_ASPH_chr8_62563609_ENST00000517847_KCTD3_chr1_215768698_ENST00000259154_length(transcript)=3348nt_BP=528nt
CCTGCCAGCAGTACTTTTGAGTTTTTTTTTTTGTTTTGTTTTACTTTAGCATTTATTATTCATGGATTGAAGAAATCAAAATGGCTGAAG
ATAAAGAGACAAAGCATGGAGGACACAAGAATGGGAGGAAAGGCGGACTCTCAGGAACTTCATTCTTCACGTGGTTTATGGTGATTGCAT
TGCTGGGCGTCTGGACATCTGTAGCTGTCGTTTGGTTTGATCTTGTTGACTATGAGGAAGTTCTAGCCAAAGCAAAGGACTTCCGTTATA
ACTTATCAGAGGTGCTTCAAGGAAAACTAGGAATCTATGATGCTGATGGTGATGGAGATTTTGATGTGGATGATGCCAAAGTTTTATTAG
GACTTAAAGAGAGATCTACTTCAGAGCCAGCAGTCCCGCCAGAAGAGGCTGAGCCACACACTGAGCCCGAGGAGCAGGTTCCTGTGGAGG
CAGAACCCCAGAATATCGAAGATGAAGCAAAAGAACAAATTCAGTCCCTTCTCCATGAAATGGTACACGCAGAACATGGAGTGTTCAGCC
TGGGTGTTCCTGTAGATGCTCTCTTCTTTATTGGTAACCAGTTGGTGGCCACGAGTCATACAGGGAAAGTGGGAGTGTGGAATGCTGTCA
CTCAGCACTGGCAGGTTCAAGATGTTGTTCCTATAACTAGTTATGACACTGCTGGATCATTCCTTCTGCTTGGATGTAACAATGGATCAA
TATATTACATAGATATGCAGAAGTTCCCCTTGCGAATGAAAGATAATGATCTTCTTGTAACTGAACTGTATCATGATCCTTCAAATGATG
CTATTACTGCTCTGAGTGTTTACCTCACACCCAAAACAAGTGTCAGTGGTAACTGGATCGAGATCGCCTATGGTACGAGCTCTGGAGCAG
TACGAGTGATTGTACAACACCCAGAGACAGTTGGGTCAGGTCCTCAGCTTTTTCAGACTTTCACAGTTCACCGAAGTCCCGTAACAAAAA
TCATGCTATCAGAGAAGCATCTTGTATCAGTCTGTGCAGATAATAATCATGTCCGGACGTGGACAGTAACACGATTCAGAGGAATGATCT
CTACTCAGCCAGGTTCTACTCCTTTAGCGTCATTCAAGATACTATCCCTGGAGGAGACAGAAAGTCATGGTAGCTATTCCTCTGGAAATG
ACATAGGACCTTTTGGAGAGCGAGACGATCAACAGGTGTTTATCCAGAAAGTTGTTCCCATCACCAACAAACTATTTGTAAGACTCTCAT
CGACTGGAAAAAGAATATGTGAGATCCAGGCTGTTGACTGTACTACAATATCCTCATTTACAGTGAGGGAATGTGAGGGATCCAGTAGGA
TGGGCTCAAGACCAAGGCGCTACTTGTTCACAGGCCATACAAATGGCAGTATTCAAATGTGGGATCTGACCACTGCTATGGATATGGTTA
ACAAAAGTGAAGATAAGGATGTAGGTGGTCCAACCGAAGAAGAGCTACTCAAATTACTCGATCAATGTGATTTGAGCACATCTCGCTGTG
CTACTCCTAACATCAGTCCAGCAACTTCCGTAGTTCAGCATAGCCACTTACGAGAATCAAATTCTAGCCTTCAGCTTCAGCACCATGATA
CCACCCATGAAGCAGCTACTTACGGTTCCATGAGGCCTTACAGAGAAAGTCCTTTATTAGCAAGGGCAAGAAGGACTGAGAGCTTTCACA
GTTATAGGGACTTCCAGACTATTAATTTGAACAGAAATGTAGAAAGAGCTGTCCCTGAAAATGGTAACTTGGGTCCAATACAAGCTGAAG
TGAAAGGGGCAACAGGGGAATGTAATATATCTGAGAGAAAGTCTCCTGGAGTAGAAATAAAAAGTTTGAGAGAATTGGATAGTGGATTGG
AAGTGCATAAAATAGCTGAAGGTTTTTCAGAATCCAAGAAAAGGTCATCAGAAGATGAAAATGAAAATAAAATAGAGTTTAGGAAGAAAG
GAGGATTTGAAGGGGGAGGATTCCTTGGAAGAAAGAAAGTTCCCTATCTGGCGTCATCACCAAGTACTTCCGATGGAGGAACTGACTCAC
CTGGTACTGCGTCCCCATCTCCTACAAAGACTACTCCATCTCCTCGGCATAAAAAAAGTGATTCTTCAGGTCAGGAGTACAGCTTGTGAA
AACTCACCAAAATGAATAGTTGTTTCGTTACATTTAGATGAAAGTTAAACTTTACTGAATTTCAGTACATTAGTTTTTACACTAAAACTT
TACAAGATAAAATTGGACTTCATTTAGTATCTTTTTAACAGAATTACTTGGAATAATGAGATACAATAATCATATCTCTTTTGACATTTT
GGAAATTTTTTTAATTTTACAAGTACATTTAACAGATCATTTATAAAGCAGGAGTCCATTTTAACACTTACCGACTTTTTTTGGTTTGGA
AACATATTACCACGTCTTAATAGGATGGTGCCCATATAGGTGAGCATCCCTTTAGATCATGGGAACCAGCAGACTGCATTCCTAATCTTC
ATTATGCCTGAGACTTGTCTTACAATGTTACCTTTAAGTGAATCACATAATTGTCTTTGGAACTTGGTCTCCCAACACTTATTGTGATTG
CAAAGTGTTTACCAGATATTTGATGAGGTGCTATGTTTGTGAAAAACATATCATGTAATTCAAAAACACTATTGATATTGAATACCAGAT
ACCACTATGTAGTAAGTCTTTTAGGATGATTTTAATTTAGTCGTGCGTCATTTTCTGATTCTCATCATTGGGAGATCTTAAATCTTAGCA
AGCATTAGCAATATTAAATGCCAAAATTCCATTGAAACTTTCAAGTTGGAGCAATTGTCTGTGTTTGAAAAGATGAAATAAAAATAATAA
TCAAGGGCAAAGCTTTGAGTGCCCAGAAGGGAAAGCTGTACCAGTTGCTAACCTGTCTTGTTTCAGGAGCCACCATGTTTTTTTTTCAGT
GTTAACAACAATCATGATAATTAAATTAAAACACTAGTTTGTTCACTTGTAGGACTGCAGTTCTGAATTTTGGGTTAAAGGTTTTGGCTG
CTGTAAGAATGTGAATTTGAATGTATTTTGAATTGTAAGAGCAAAAGAACGTTTTTGTACAATTTTTTTTCATTTAATTGGAATGATCTT
CAGGTTTCTACAAATAGGGTAATTGTAAATTTAAAGCATTAGCATTTATTGGTGAATAATGTATATATCCCCATTCCAAGAAATATAAGT
GAGTGAAGTTGAAATAAAATCTTTAAAATTTACTATATTGCCAGTGGTTTCACAACAGTTCTCTTGTATTTATTTATCAATTAAATCAAA
TAAAAATGATTATGTCAA

>7208_7208_4_ASPH-KCTD3_ASPH_chr8_62563609_ENST00000517847_KCTD3_chr1_215768698_ENST00000259154_length(amino acids)=707AA_BP=164
MFYFSIYYSWIEEIKMAEDKETKHGGHKNGRKGGLSGTSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLAKAKDFRYNLSEVLQGKLGI
YDADGDGDFDVDDAKVLLGLKERSTSEPAVPPEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHGVFSLGVPVDALFFIG
NQLVATSHTGKVGVWNAVTQHWQVQDVVPITSYDTAGSFLLLGCNNGSIYYIDMQKFPLRMKDNDLLVTELYHDPSNDAITALSVYLTPK
TSVSGNWIEIAYGTSSGAVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLVSVCADNNHVRTWTVTRFRGMISTQPGSTPLASF
KILSLEETESHGSYSSGNDIGPFGERDDQQVFIQKVVPITNKLFVRLSSTGKRICEIQAVDCTTISSFTVRECEGSSRMGSRPRRYLFTG
HTNGSIQMWDLTTAMDMVNKSEDKDVGGPTEEELLKLLDQCDLSTSRCATPNISPATSVVQHSHLRESNSSLQLQHHDTTHEAATYGSMR
PYRESPLLARARRTESFHSYRDFQTINLNRNVERAVPENGNLGPIQAEVKGATGECNISERKSPGVEIKSLRELDSGLEVHKIAEGFSES
KKRSSEDENENKIEFRKKGGFEGGGFLGRKKVPYLASSPSTSDGGTDSPGTASPSPTKTTPSPRHKKSDSSGQEYSL

--------------------------------------------------------------
>7208_7208_5_ASPH-KCTD3_ASPH_chr8_62563609_ENST00000517903_KCTD3_chr1_215768698_ENST00000259154_length(transcript)=3359nt_BP=539nt
TGTGCCTAAAACCTGCCAGCAGTACTTTTGAGTTTTTTTTTTTGTTTTGTTTTACTTTAGCATTTATTATTCATGGATTGAAGAAATCAA
AATGGCTGAAGATAAAGAGACAAAGCATGGAGGACACAAGAATGGGAGGAAAGGCGGACTCTCAGGAACTTCATTCTTCACGTGGTTTAT
GGTGATTGCATTGCTGGGCGTCTGGACATCTGTAGCTGTCGTTTGGTTTGATCTTGTTGACTATGAGGAAGTTCTAGCCAAAGCAAAGGA
CTTCCGTTATAACTTATCAGAGGTGCTTCAAGGAAAACTAGGAATCTATGATGCTGATGGTGATGGAGATTTTGATGTGGATGATGCCAA
AGTTTTATTAGGACTTAAAGAGAGATCTACTTCAGAGCCAGCAGTCCCGCCAGAAGAGGCTGAGCCACACACTGAGCCCGAGGAGCAGGT
TCCTGTGGAGGCAGAACCCCAGAATATCGAAGATGAAGCAAAAGAACAAATTCAGTCCCTTCTCCATGAAATGGTACACGCAGAACATGG
AGTGTTCAGCCTGGGTGTTCCTGTAGATGCTCTCTTCTTTATTGGTAACCAGTTGGTGGCCACGAGTCATACAGGGAAAGTGGGAGTGTG
GAATGCTGTCACTCAGCACTGGCAGGTTCAAGATGTTGTTCCTATAACTAGTTATGACACTGCTGGATCATTCCTTCTGCTTGGATGTAA
CAATGGATCAATATATTACATAGATATGCAGAAGTTCCCCTTGCGAATGAAAGATAATGATCTTCTTGTAACTGAACTGTATCATGATCC
TTCAAATGATGCTATTACTGCTCTGAGTGTTTACCTCACACCCAAAACAAGTGTCAGTGGTAACTGGATCGAGATCGCCTATGGTACGAG
CTCTGGAGCAGTACGAGTGATTGTACAACACCCAGAGACAGTTGGGTCAGGTCCTCAGCTTTTTCAGACTTTCACAGTTCACCGAAGTCC
CGTAACAAAAATCATGCTATCAGAGAAGCATCTTGTATCAGTCTGTGCAGATAATAATCATGTCCGGACGTGGACAGTAACACGATTCAG
AGGAATGATCTCTACTCAGCCAGGTTCTACTCCTTTAGCGTCATTCAAGATACTATCCCTGGAGGAGACAGAAAGTCATGGTAGCTATTC
CTCTGGAAATGACATAGGACCTTTTGGAGAGCGAGACGATCAACAGGTGTTTATCCAGAAAGTTGTTCCCATCACCAACAAACTATTTGT
AAGACTCTCATCGACTGGAAAAAGAATATGTGAGATCCAGGCTGTTGACTGTACTACAATATCCTCATTTACAGTGAGGGAATGTGAGGG
ATCCAGTAGGATGGGCTCAAGACCAAGGCGCTACTTGTTCACAGGCCATACAAATGGCAGTATTCAAATGTGGGATCTGACCACTGCTAT
GGATATGGTTAACAAAAGTGAAGATAAGGATGTAGGTGGTCCAACCGAAGAAGAGCTACTCAAATTACTCGATCAATGTGATTTGAGCAC
ATCTCGCTGTGCTACTCCTAACATCAGTCCAGCAACTTCCGTAGTTCAGCATAGCCACTTACGAGAATCAAATTCTAGCCTTCAGCTTCA
GCACCATGATACCACCCATGAAGCAGCTACTTACGGTTCCATGAGGCCTTACAGAGAAAGTCCTTTATTAGCAAGGGCAAGAAGGACTGA
GAGCTTTCACAGTTATAGGGACTTCCAGACTATTAATTTGAACAGAAATGTAGAAAGAGCTGTCCCTGAAAATGGTAACTTGGGTCCAAT
ACAAGCTGAAGTGAAAGGGGCAACAGGGGAATGTAATATATCTGAGAGAAAGTCTCCTGGAGTAGAAATAAAAAGTTTGAGAGAATTGGA
TAGTGGATTGGAAGTGCATAAAATAGCTGAAGGTTTTTCAGAATCCAAGAAAAGGTCATCAGAAGATGAAAATGAAAATAAAATAGAGTT
TAGGAAGAAAGGAGGATTTGAAGGGGGAGGATTCCTTGGAAGAAAGAAAGTTCCCTATCTGGCGTCATCACCAAGTACTTCCGATGGAGG
AACTGACTCACCTGGTACTGCGTCCCCATCTCCTACAAAGACTACTCCATCTCCTCGGCATAAAAAAAGTGATTCTTCAGGTCAGGAGTA
CAGCTTGTGAAAACTCACCAAAATGAATAGTTGTTTCGTTACATTTAGATGAAAGTTAAACTTTACTGAATTTCAGTACATTAGTTTTTA
CACTAAAACTTTACAAGATAAAATTGGACTTCATTTAGTATCTTTTTAACAGAATTACTTGGAATAATGAGATACAATAATCATATCTCT
TTTGACATTTTGGAAATTTTTTTAATTTTACAAGTACATTTAACAGATCATTTATAAAGCAGGAGTCCATTTTAACACTTACCGACTTTT
TTTGGTTTGGAAACATATTACCACGTCTTAATAGGATGGTGCCCATATAGGTGAGCATCCCTTTAGATCATGGGAACCAGCAGACTGCAT
TCCTAATCTTCATTATGCCTGAGACTTGTCTTACAATGTTACCTTTAAGTGAATCACATAATTGTCTTTGGAACTTGGTCTCCCAACACT
TATTGTGATTGCAAAGTGTTTACCAGATATTTGATGAGGTGCTATGTTTGTGAAAAACATATCATGTAATTCAAAAACACTATTGATATT
GAATACCAGATACCACTATGTAGTAAGTCTTTTAGGATGATTTTAATTTAGTCGTGCGTCATTTTCTGATTCTCATCATTGGGAGATCTT
AAATCTTAGCAAGCATTAGCAATATTAAATGCCAAAATTCCATTGAAACTTTCAAGTTGGAGCAATTGTCTGTGTTTGAAAAGATGAAAT
AAAAATAATAATCAAGGGCAAAGCTTTGAGTGCCCAGAAGGGAAAGCTGTACCAGTTGCTAACCTGTCTTGTTTCAGGAGCCACCATGTT
TTTTTTTCAGTGTTAACAACAATCATGATAATTAAATTAAAACACTAGTTTGTTCACTTGTAGGACTGCAGTTCTGAATTTTGGGTTAAA
GGTTTTGGCTGCTGTAAGAATGTGAATTTGAATGTATTTTGAATTGTAAGAGCAAAAGAACGTTTTTGTACAATTTTTTTTCATTTAATT
GGAATGATCTTCAGGTTTCTACAAATAGGGTAATTGTAAATTTAAAGCATTAGCATTTATTGGTGAATAATGTATATATCCCCATTCCAA
GAAATATAAGTGAGTGAAGTTGAAATAAAATCTTTAAAATTTACTATATTGCCAGTGGTTTCACAACAGTTCTCTTGTATTTATTTATCA
ATTAAATCAAATAAAAATGATTATGTCAA

>7208_7208_5_ASPH-KCTD3_ASPH_chr8_62563609_ENST00000517903_KCTD3_chr1_215768698_ENST00000259154_length(amino acids)=707AA_BP=164
MFYFSIYYSWIEEIKMAEDKETKHGGHKNGRKGGLSGTSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLAKAKDFRYNLSEVLQGKLGI
YDADGDGDFDVDDAKVLLGLKERSTSEPAVPPEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHGVFSLGVPVDALFFIG
NQLVATSHTGKVGVWNAVTQHWQVQDVVPITSYDTAGSFLLLGCNNGSIYYIDMQKFPLRMKDNDLLVTELYHDPSNDAITALSVYLTPK
TSVSGNWIEIAYGTSSGAVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLVSVCADNNHVRTWTVTRFRGMISTQPGSTPLASF
KILSLEETESHGSYSSGNDIGPFGERDDQQVFIQKVVPITNKLFVRLSSTGKRICEIQAVDCTTISSFTVRECEGSSRMGSRPRRYLFTG
HTNGSIQMWDLTTAMDMVNKSEDKDVGGPTEEELLKLLDQCDLSTSRCATPNISPATSVVQHSHLRESNSSLQLQHHDTTHEAATYGSMR
PYRESPLLARARRTESFHSYRDFQTINLNRNVERAVPENGNLGPIQAEVKGATGECNISERKSPGVEIKSLRELDSGLEVHKIAEGFSES
KKRSSEDENENKIEFRKKGGFEGGGFLGRKKVPYLASSPSTSDGGTDSPGTASPSPTKTTPSPRHKKSDSSGQEYSL

--------------------------------------------------------------
>7208_7208_6_ASPH-KCTD3_ASPH_chr8_62563609_ENST00000518068_KCTD3_chr1_215768698_ENST00000259154_length(transcript)=3507nt_BP=687nt
CCGGGCGCGCGCAGCCGGCAGGCGGGTGAAGTCTTCCCAGGTGCTGCAGGCGGTGCTGAGGCACAGGGTCTGCTGCAGGAGCAGCGGCCC
GAACCCGCTCCAGCGGCCCGCCGCCGCCAGCGGTTCCCGCGTCGCGTGTGTACCCCCGCGCACTGAAGGAGGTCCGCCAGCCCTCACCAG
CCCCCGCGGACCGTGCAATGGCCCAGCGTAAGAATGCCAAGAGCAGCGGCAACAGCAGCAGCAGCGGCTCCGGCAGCGGTAGCACGAGTG
CGGGCAGCAGCAGCCCCGGGGCCCGGAGAGAGACAAAGCATGGAGGACACAAGAATGGGAGGAAAGGCGGACTCTCAGGAACTTCATTCT
TCACGTGGTTTATGGTGATTGCATTGCTGGGCGTCTGGACATCTGTAGCTGTCGTTTGGTTTGATCTTGTTGACTATGAGGAAGTTCTAG
GAAAACTAGGAATCTATGATGCTGATGGTGATGGAGATTTTGATGTGGATGATGCCAAAGTTTTATTAGGACTTAAAGAGAGATCTACTT
CAGAGCCAGCAGTCCCGCCAGAAGAGGCTGAGCCACACACTGAGCCCGAGGAGCAGGTTCCTGTGGAGGCAGAACCCCAGAATATCGAAG
ATGAAGCAAAAGAACAAATTCAGTCCCTTCTCCATGAAATGGTACACGCAGAACATGGAGTGTTCAGCCTGGGTGTTCCTGTAGATGCTC
TCTTCTTTATTGGTAACCAGTTGGTGGCCACGAGTCATACAGGGAAAGTGGGAGTGTGGAATGCTGTCACTCAGCACTGGCAGGTTCAAG
ATGTTGTTCCTATAACTAGTTATGACACTGCTGGATCATTCCTTCTGCTTGGATGTAACAATGGATCAATATATTACATAGATATGCAGA
AGTTCCCCTTGCGAATGAAAGATAATGATCTTCTTGTAACTGAACTGTATCATGATCCTTCAAATGATGCTATTACTGCTCTGAGTGTTT
ACCTCACACCCAAAACAAGTGTCAGTGGTAACTGGATCGAGATCGCCTATGGTACGAGCTCTGGAGCAGTACGAGTGATTGTACAACACC
CAGAGACAGTTGGGTCAGGTCCTCAGCTTTTTCAGACTTTCACAGTTCACCGAAGTCCCGTAACAAAAATCATGCTATCAGAGAAGCATC
TTGTATCAGTCTGTGCAGATAATAATCATGTCCGGACGTGGACAGTAACACGATTCAGAGGAATGATCTCTACTCAGCCAGGTTCTACTC
CTTTAGCGTCATTCAAGATACTATCCCTGGAGGAGACAGAAAGTCATGGTAGCTATTCCTCTGGAAATGACATAGGACCTTTTGGAGAGC
GAGACGATCAACAGGTGTTTATCCAGAAAGTTGTTCCCATCACCAACAAACTATTTGTAAGACTCTCATCGACTGGAAAAAGAATATGTG
AGATCCAGGCTGTTGACTGTACTACAATATCCTCATTTACAGTGAGGGAATGTGAGGGATCCAGTAGGATGGGCTCAAGACCAAGGCGCT
ACTTGTTCACAGGCCATACAAATGGCAGTATTCAAATGTGGGATCTGACCACTGCTATGGATATGGTTAACAAAAGTGAAGATAAGGATG
TAGGTGGTCCAACCGAAGAAGAGCTACTCAAATTACTCGATCAATGTGATTTGAGCACATCTCGCTGTGCTACTCCTAACATCAGTCCAG
CAACTTCCGTAGTTCAGCATAGCCACTTACGAGAATCAAATTCTAGCCTTCAGCTTCAGCACCATGATACCACCCATGAAGCAGCTACTT
ACGGTTCCATGAGGCCTTACAGAGAAAGTCCTTTATTAGCAAGGGCAAGAAGGACTGAGAGCTTTCACAGTTATAGGGACTTCCAGACTA
TTAATTTGAACAGAAATGTAGAAAGAGCTGTCCCTGAAAATGGTAACTTGGGTCCAATACAAGCTGAAGTGAAAGGGGCAACAGGGGAAT
GTAATATATCTGAGAGAAAGTCTCCTGGAGTAGAAATAAAAAGTTTGAGAGAATTGGATAGTGGATTGGAAGTGCATAAAATAGCTGAAG
GTTTTTCAGAATCCAAGAAAAGGTCATCAGAAGATGAAAATGAAAATAAAATAGAGTTTAGGAAGAAAGGAGGATTTGAAGGGGGAGGAT
TCCTTGGAAGAAAGAAAGTTCCCTATCTGGCGTCATCACCAAGTACTTCCGATGGAGGAACTGACTCACCTGGTACTGCGTCCCCATCTC
CTACAAAGACTACTCCATCTCCTCGGCATAAAAAAAGTGATTCTTCAGGTCAGGAGTACAGCTTGTGAAAACTCACCAAAATGAATAGTT
GTTTCGTTACATTTAGATGAAAGTTAAACTTTACTGAATTTCAGTACATTAGTTTTTACACTAAAACTTTACAAGATAAAATTGGACTTC
ATTTAGTATCTTTTTAACAGAATTACTTGGAATAATGAGATACAATAATCATATCTCTTTTGACATTTTGGAAATTTTTTTAATTTTACA
AGTACATTTAACAGATCATTTATAAAGCAGGAGTCCATTTTAACACTTACCGACTTTTTTTGGTTTGGAAACATATTACCACGTCTTAAT
AGGATGGTGCCCATATAGGTGAGCATCCCTTTAGATCATGGGAACCAGCAGACTGCATTCCTAATCTTCATTATGCCTGAGACTTGTCTT
ACAATGTTACCTTTAAGTGAATCACATAATTGTCTTTGGAACTTGGTCTCCCAACACTTATTGTGATTGCAAAGTGTTTACCAGATATTT
GATGAGGTGCTATGTTTGTGAAAAACATATCATGTAATTCAAAAACACTATTGATATTGAATACCAGATACCACTATGTAGTAAGTCTTT
TAGGATGATTTTAATTTAGTCGTGCGTCATTTTCTGATTCTCATCATTGGGAGATCTTAAATCTTAGCAAGCATTAGCAATATTAAATGC
CAAAATTCCATTGAAACTTTCAAGTTGGAGCAATTGTCTGTGTTTGAAAAGATGAAATAAAAATAATAATCAAGGGCAAAGCTTTGAGTG
CCCAGAAGGGAAAGCTGTACCAGTTGCTAACCTGTCTTGTTTCAGGAGCCACCATGTTTTTTTTTCAGTGTTAACAACAATCATGATAAT
TAAATTAAAACACTAGTTTGTTCACTTGTAGGACTGCAGTTCTGAATTTTGGGTTAAAGGTTTTGGCTGCTGTAAGAATGTGAATTTGAA
TGTATTTTGAATTGTAAGAGCAAAAGAACGTTTTTGTACAATTTTTTTTCATTTAATTGGAATGATCTTCAGGTTTCTACAAATAGGGTA
ATTGTAAATTTAAAGCATTAGCATTTATTGGTGAATAATGTATATATCCCCATTCCAAGAAATATAAGTGAGTGAAGTTGAAATAAAATC
TTTAAAATTTACTATATTGCCAGTGGTTTCACAACAGTTCTCTTGTATTTATTTATCAATTAAATCAAATAAAAATGATTATGTCAA

>7208_7208_6_ASPH-KCTD3_ASPH_chr8_62563609_ENST00000518068_KCTD3_chr1_215768698_ENST00000259154_length(amino acids)=721AA_BP=178
MKEVRQPSPAPADRAMAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGGHKNGRKGGLSGTSFFTWFMVIALLGVWTSVAVVWF
DLVDYEEVLGKLGIYDADGDGDFDVDDAKVLLGLKERSTSEPAVPPEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHGV
FSLGVPVDALFFIGNQLVATSHTGKVGVWNAVTQHWQVQDVVPITSYDTAGSFLLLGCNNGSIYYIDMQKFPLRMKDNDLLVTELYHDPS
NDAITALSVYLTPKTSVSGNWIEIAYGTSSGAVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLVSVCADNNHVRTWTVTRFRG
MISTQPGSTPLASFKILSLEETESHGSYSSGNDIGPFGERDDQQVFIQKVVPITNKLFVRLSSTGKRICEIQAVDCTTISSFTVRECEGS
SRMGSRPRRYLFTGHTNGSIQMWDLTTAMDMVNKSEDKDVGGPTEEELLKLLDQCDLSTSRCATPNISPATSVVQHSHLRESNSSLQLQH
HDTTHEAATYGSMRPYRESPLLARARRTESFHSYRDFQTINLNRNVERAVPENGNLGPIQAEVKGATGECNISERKSPGVEIKSLRELDS
GLEVHKIAEGFSESKKRSSEDENENKIEFRKKGGFEGGGFLGRKKVPYLASSPSTSDGGTDSPGTASPSPTKTTPSPRHKKSDSSGQEYS
L

--------------------------------------------------------------
>7208_7208_7_ASPH-KCTD3_ASPH_chr8_62563609_ENST00000522835_KCTD3_chr1_215768698_ENST00000259154_length(transcript)=3392nt_BP=572nt
CAGTCTCAAGCTCTGGTAGGCAAGTGCATGCAGTGTGCCTAAAACCTGCCAGCAGTACTTTTGAGTTTTTTTTTTTGTTTTGTTTTACTT
TAGCATTTATTATTCATGGATTGAAGAAATCAAAATGGCTGAAGATAAAGAGACAAAGCATGGAGGACACAAGAATGGGAGGAAAGGCGG
ACTCTCAGGAACTTCATTCTTCACGTGGTTTATGGTGATTGCATTGCTGGGCGTCTGGACATCTGTAGCTGTCGTTTGGTTTGATCTTGT
TGACTATGAGGAAGTTCTAGCCAAAGCAAAGGACTTCCGTTATAACTTATCAGAGGTGCTTCAAGGAAAACTAGGAATCTATGATGCTGA
TGGTGATGGAGATTTTGATGTGGATGATGCCAAAGTTTTATTAGGACTTAAAGAGAGATCTACTTCAGAGCCAGCAGTCCCGCCAGAAGA
GGCTGAGCCACACACTGAGCCCGAGGAGCAGGTTCCTGTGGAGGCAGAACCCCAGAATATCGAAGATGAAGCAAAAGAACAAATTCAGTC
CCTTCTCCATGAAATGGTACACGCAGAACATGGAGTGTTCAGCCTGGGTGTTCCTGTAGATGCTCTCTTCTTTATTGGTAACCAGTTGGT
GGCCACGAGTCATACAGGGAAAGTGGGAGTGTGGAATGCTGTCACTCAGCACTGGCAGGTTCAAGATGTTGTTCCTATAACTAGTTATGA
CACTGCTGGATCATTCCTTCTGCTTGGATGTAACAATGGATCAATATATTACATAGATATGCAGAAGTTCCCCTTGCGAATGAAAGATAA
TGATCTTCTTGTAACTGAACTGTATCATGATCCTTCAAATGATGCTATTACTGCTCTGAGTGTTTACCTCACACCCAAAACAAGTGTCAG
TGGTAACTGGATCGAGATCGCCTATGGTACGAGCTCTGGAGCAGTACGAGTGATTGTACAACACCCAGAGACAGTTGGGTCAGGTCCTCA
GCTTTTTCAGACTTTCACAGTTCACCGAAGTCCCGTAACAAAAATCATGCTATCAGAGAAGCATCTTGTATCAGTCTGTGCAGATAATAA
TCATGTCCGGACGTGGACAGTAACACGATTCAGAGGAATGATCTCTACTCAGCCAGGTTCTACTCCTTTAGCGTCATTCAAGATACTATC
CCTGGAGGAGACAGAAAGTCATGGTAGCTATTCCTCTGGAAATGACATAGGACCTTTTGGAGAGCGAGACGATCAACAGGTGTTTATCCA
GAAAGTTGTTCCCATCACCAACAAACTATTTGTAAGACTCTCATCGACTGGAAAAAGAATATGTGAGATCCAGGCTGTTGACTGTACTAC
AATATCCTCATTTACAGTGAGGGAATGTGAGGGATCCAGTAGGATGGGCTCAAGACCAAGGCGCTACTTGTTCACAGGCCATACAAATGG
CAGTATTCAAATGTGGGATCTGACCACTGCTATGGATATGGTTAACAAAAGTGAAGATAAGGATGTAGGTGGTCCAACCGAAGAAGAGCT
ACTCAAATTACTCGATCAATGTGATTTGAGCACATCTCGCTGTGCTACTCCTAACATCAGTCCAGCAACTTCCGTAGTTCAGCATAGCCA
CTTACGAGAATCAAATTCTAGCCTTCAGCTTCAGCACCATGATACCACCCATGAAGCAGCTACTTACGGTTCCATGAGGCCTTACAGAGA
AAGTCCTTTATTAGCAAGGGCAAGAAGGACTGAGAGCTTTCACAGTTATAGGGACTTCCAGACTATTAATTTGAACAGAAATGTAGAAAG
AGCTGTCCCTGAAAATGGTAACTTGGGTCCAATACAAGCTGAAGTGAAAGGGGCAACAGGGGAATGTAATATATCTGAGAGAAAGTCTCC
TGGAGTAGAAATAAAAAGTTTGAGAGAATTGGATAGTGGATTGGAAGTGCATAAAATAGCTGAAGGTTTTTCAGAATCCAAGAAAAGGTC
ATCAGAAGATGAAAATGAAAATAAAATAGAGTTTAGGAAGAAAGGAGGATTTGAAGGGGGAGGATTCCTTGGAAGAAAGAAAGTTCCCTA
TCTGGCGTCATCACCAAGTACTTCCGATGGAGGAACTGACTCACCTGGTACTGCGTCCCCATCTCCTACAAAGACTACTCCATCTCCTCG
GCATAAAAAAAGTGATTCTTCAGGTCAGGAGTACAGCTTGTGAAAACTCACCAAAATGAATAGTTGTTTCGTTACATTTAGATGAAAGTT
AAACTTTACTGAATTTCAGTACATTAGTTTTTACACTAAAACTTTACAAGATAAAATTGGACTTCATTTAGTATCTTTTTAACAGAATTA
CTTGGAATAATGAGATACAATAATCATATCTCTTTTGACATTTTGGAAATTTTTTTAATTTTACAAGTACATTTAACAGATCATTTATAA
AGCAGGAGTCCATTTTAACACTTACCGACTTTTTTTGGTTTGGAAACATATTACCACGTCTTAATAGGATGGTGCCCATATAGGTGAGCA
TCCCTTTAGATCATGGGAACCAGCAGACTGCATTCCTAATCTTCATTATGCCTGAGACTTGTCTTACAATGTTACCTTTAAGTGAATCAC
ATAATTGTCTTTGGAACTTGGTCTCCCAACACTTATTGTGATTGCAAAGTGTTTACCAGATATTTGATGAGGTGCTATGTTTGTGAAAAA
CATATCATGTAATTCAAAAACACTATTGATATTGAATACCAGATACCACTATGTAGTAAGTCTTTTAGGATGATTTTAATTTAGTCGTGC
GTCATTTTCTGATTCTCATCATTGGGAGATCTTAAATCTTAGCAAGCATTAGCAATATTAAATGCCAAAATTCCATTGAAACTTTCAAGT
TGGAGCAATTGTCTGTGTTTGAAAAGATGAAATAAAAATAATAATCAAGGGCAAAGCTTTGAGTGCCCAGAAGGGAAAGCTGTACCAGTT
GCTAACCTGTCTTGTTTCAGGAGCCACCATGTTTTTTTTTCAGTGTTAACAACAATCATGATAATTAAATTAAAACACTAGTTTGTTCAC
TTGTAGGACTGCAGTTCTGAATTTTGGGTTAAAGGTTTTGGCTGCTGTAAGAATGTGAATTTGAATGTATTTTGAATTGTAAGAGCAAAA
GAACGTTTTTGTACAATTTTTTTTCATTTAATTGGAATGATCTTCAGGTTTCTACAAATAGGGTAATTGTAAATTTAAAGCATTAGCATT
TATTGGTGAATAATGTATATATCCCCATTCCAAGAAATATAAGTGAGTGAAGTTGAAATAAAATCTTTAAAATTTACTATATTGCCAGTG
GTTTCACAACAGTTCTCTTGTATTTATTTATCAATTAAATCAAATAAAAATGATTATGTCAA

>7208_7208_7_ASPH-KCTD3_ASPH_chr8_62563609_ENST00000522835_KCTD3_chr1_215768698_ENST00000259154_length(amino acids)=707AA_BP=164
MFYFSIYYSWIEEIKMAEDKETKHGGHKNGRKGGLSGTSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLAKAKDFRYNLSEVLQGKLGI
YDADGDGDFDVDDAKVLLGLKERSTSEPAVPPEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHGVFSLGVPVDALFFIG
NQLVATSHTGKVGVWNAVTQHWQVQDVVPITSYDTAGSFLLLGCNNGSIYYIDMQKFPLRMKDNDLLVTELYHDPSNDAITALSVYLTPK
TSVSGNWIEIAYGTSSGAVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLVSVCADNNHVRTWTVTRFRGMISTQPGSTPLASF
KILSLEETESHGSYSSGNDIGPFGERDDQQVFIQKVVPITNKLFVRLSSTGKRICEIQAVDCTTISSFTVRECEGSSRMGSRPRRYLFTG
HTNGSIQMWDLTTAMDMVNKSEDKDVGGPTEEELLKLLDQCDLSTSRCATPNISPATSVVQHSHLRESNSSLQLQHHDTTHEAATYGSMR
PYRESPLLARARRTESFHSYRDFQTINLNRNVERAVPENGNLGPIQAEVKGATGECNISERKSPGVEIKSLRELDSGLEVHKIAEGFSES
KKRSSEDENENKIEFRKKGGFEGGGFLGRKKVPYLASSPSTSDGGTDSPGTASPSPTKTTPSPRHKKSDSSGQEYSL

--------------------------------------------------------------
>7208_7208_8_ASPH-KCTD3_ASPH_chr8_62563609_ENST00000541428_KCTD3_chr1_215768698_ENST00000259154_length(transcript)=3384nt_BP=564nt
TTTCAGTTCTAGAGGCCCTTACAGTGCAGGGATTGGCCAGTCTCAAGCTCTGGTAGGCAAGTGCATGCAGTGTGCCTAAAACCTGCCAGC
AGTACTTTTGAGTTTTTTTTTTTGTTTTGTTTTACTTTAGCATTTATTATTCATGGATTGAAGAAATCAAAATGGCTGAAGATAAAGAGA
CAAAGCATGGAGGACACAAGAATGGGAGGAAAGGCGGACTCTCAGGAACTTCATTCTTCACGTGGTTTATGGTGATTGCATTGCTGGGCG
TCTGGACATCTGTAGCTGTCGTTTGGTTTGATCTTGTTGACTATGAGGAAGTTCTAGGAAAACTAGGAATCTATGATGCTGATGGTGATG
GAGATTTTGATGTGGATGATGCCAAAGTTTTATTAGGACTTAAAGAGAGATCTACTTCAGAGCCAGCAGTCCCGCCAGAAGAGGCTGAGC
CACACACTGAGCCCGAGGAGCAGGTTCCTGTGGAGGCAGAACCCCAGAATATCGAAGATGAAGCAAAAGAACAAATTCAGTCCCTTCTCC
ATGAAATGGTACACGCAGAACATGGAGTGTTCAGCCTGGGTGTTCCTGTAGATGCTCTCTTCTTTATTGGTAACCAGTTGGTGGCCACGA
GTCATACAGGGAAAGTGGGAGTGTGGAATGCTGTCACTCAGCACTGGCAGGTTCAAGATGTTGTTCCTATAACTAGTTATGACACTGCTG
GATCATTCCTTCTGCTTGGATGTAACAATGGATCAATATATTACATAGATATGCAGAAGTTCCCCTTGCGAATGAAAGATAATGATCTTC
TTGTAACTGAACTGTATCATGATCCTTCAAATGATGCTATTACTGCTCTGAGTGTTTACCTCACACCCAAAACAAGTGTCAGTGGTAACT
GGATCGAGATCGCCTATGGTACGAGCTCTGGAGCAGTACGAGTGATTGTACAACACCCAGAGACAGTTGGGTCAGGTCCTCAGCTTTTTC
AGACTTTCACAGTTCACCGAAGTCCCGTAACAAAAATCATGCTATCAGAGAAGCATCTTGTATCAGTCTGTGCAGATAATAATCATGTCC
GGACGTGGACAGTAACACGATTCAGAGGAATGATCTCTACTCAGCCAGGTTCTACTCCTTTAGCGTCATTCAAGATACTATCCCTGGAGG
AGACAGAAAGTCATGGTAGCTATTCCTCTGGAAATGACATAGGACCTTTTGGAGAGCGAGACGATCAACAGGTGTTTATCCAGAAAGTTG
TTCCCATCACCAACAAACTATTTGTAAGACTCTCATCGACTGGAAAAAGAATATGTGAGATCCAGGCTGTTGACTGTACTACAATATCCT
CATTTACAGTGAGGGAATGTGAGGGATCCAGTAGGATGGGCTCAAGACCAAGGCGCTACTTGTTCACAGGCCATACAAATGGCAGTATTC
AAATGTGGGATCTGACCACTGCTATGGATATGGTTAACAAAAGTGAAGATAAGGATGTAGGTGGTCCAACCGAAGAAGAGCTACTCAAAT
TACTCGATCAATGTGATTTGAGCACATCTCGCTGTGCTACTCCTAACATCAGTCCAGCAACTTCCGTAGTTCAGCATAGCCACTTACGAG
AATCAAATTCTAGCCTTCAGCTTCAGCACCATGATACCACCCATGAAGCAGCTACTTACGGTTCCATGAGGCCTTACAGAGAAAGTCCTT
TATTAGCAAGGGCAAGAAGGACTGAGAGCTTTCACAGTTATAGGGACTTCCAGACTATTAATTTGAACAGAAATGTAGAAAGAGCTGTCC
CTGAAAATGGTAACTTGGGTCCAATACAAGCTGAAGTGAAAGGGGCAACAGGGGAATGTAATATATCTGAGAGAAAGTCTCCTGGAGTAG
AAATAAAAAGTTTGAGAGAATTGGATAGTGGATTGGAAGTGCATAAAATAGCTGAAGGTTTTTCAGAATCCAAGAAAAGGTCATCAGAAG
ATGAAAATGAAAATAAAATAGAGTTTAGGAAGAAAGGAGGATTTGAAGGGGGAGGATTCCTTGGAAGAAAGAAAGTTCCCTATCTGGCGT
CATCACCAAGTACTTCCGATGGAGGAACTGACTCACCTGGTACTGCGTCCCCATCTCCTACAAAGACTACTCCATCTCCTCGGCATAAAA
AAAGTGATTCTTCAGGTCAGGAGTACAGCTTGTGAAAACTCACCAAAATGAATAGTTGTTTCGTTACATTTAGATGAAAGTTAAACTTTA
CTGAATTTCAGTACATTAGTTTTTACACTAAAACTTTACAAGATAAAATTGGACTTCATTTAGTATCTTTTTAACAGAATTACTTGGAAT
AATGAGATACAATAATCATATCTCTTTTGACATTTTGGAAATTTTTTTAATTTTACAAGTACATTTAACAGATCATTTATAAAGCAGGAG
TCCATTTTAACACTTACCGACTTTTTTTGGTTTGGAAACATATTACCACGTCTTAATAGGATGGTGCCCATATAGGTGAGCATCCCTTTA
GATCATGGGAACCAGCAGACTGCATTCCTAATCTTCATTATGCCTGAGACTTGTCTTACAATGTTACCTTTAAGTGAATCACATAATTGT
CTTTGGAACTTGGTCTCCCAACACTTATTGTGATTGCAAAGTGTTTACCAGATATTTGATGAGGTGCTATGTTTGTGAAAAACATATCAT
GTAATTCAAAAACACTATTGATATTGAATACCAGATACCACTATGTAGTAAGTCTTTTAGGATGATTTTAATTTAGTCGTGCGTCATTTT
CTGATTCTCATCATTGGGAGATCTTAAATCTTAGCAAGCATTAGCAATATTAAATGCCAAAATTCCATTGAAACTTTCAAGTTGGAGCAA
TTGTCTGTGTTTGAAAAGATGAAATAAAAATAATAATCAAGGGCAAAGCTTTGAGTGCCCAGAAGGGAAAGCTGTACCAGTTGCTAACCT
GTCTTGTTTCAGGAGCCACCATGTTTTTTTTTCAGTGTTAACAACAATCATGATAATTAAATTAAAACACTAGTTTGTTCACTTGTAGGA
CTGCAGTTCTGAATTTTGGGTTAAAGGTTTTGGCTGCTGTAAGAATGTGAATTTGAATGTATTTTGAATTGTAAGAGCAAAAGAACGTTT
TTGTACAATTTTTTTTCATTTAATTGGAATGATCTTCAGGTTTCTACAAATAGGGTAATTGTAAATTTAAAGCATTAGCATTTATTGGTG
AATAATGTATATATCCCCATTCCAAGAAATATAAGTGAGTGAAGTTGAAATAAAATCTTTAAAATTTACTATATTGCCAGTGGTTTCACA
ACAGTTCTCTTGTATTTATTTATCAATTAAATCAAATAAAAATGATTATGTCAA

>7208_7208_8_ASPH-KCTD3_ASPH_chr8_62563609_ENST00000541428_KCTD3_chr1_215768698_ENST00000259154_length(amino acids)=692AA_BP=149
MFYFSIYYSWIEEIKMAEDKETKHGGHKNGRKGGLSGTSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLGKLGIYDADGDGDFDVDDAK
VLLGLKERSTSEPAVPPEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHGVFSLGVPVDALFFIGNQLVATSHTGKVGVW
NAVTQHWQVQDVVPITSYDTAGSFLLLGCNNGSIYYIDMQKFPLRMKDNDLLVTELYHDPSNDAITALSVYLTPKTSVSGNWIEIAYGTS
SGAVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLVSVCADNNHVRTWTVTRFRGMISTQPGSTPLASFKILSLEETESHGSYS
SGNDIGPFGERDDQQVFIQKVVPITNKLFVRLSSTGKRICEIQAVDCTTISSFTVRECEGSSRMGSRPRRYLFTGHTNGSIQMWDLTTAM
DMVNKSEDKDVGGPTEEELLKLLDQCDLSTSRCATPNISPATSVVQHSHLRESNSSLQLQHHDTTHEAATYGSMRPYRESPLLARARRTE
SFHSYRDFQTINLNRNVERAVPENGNLGPIQAEVKGATGECNISERKSPGVEIKSLRELDSGLEVHKIAEGFSESKKRSSEDENENKIEF
RKKGGFEGGGFLGRKKVPYLASSPSTSDGGTDSPGTASPSPTKTTPSPRHKKSDSSGQEYSL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ASPH-KCTD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneKCTD3chr8:62563609chr1:215768698ENST00000259154818512_815272.3333333333333816.0HCN3


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASPH-KCTD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASPH-KCTD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASPHC1832167Ectopia Lentis, Spontaneous Filtering Blebs, and Craniofacial Dysmorphism1CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0543888Epileptic encephalopathy1GENOMICS_ENGLAND