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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASPH-TACC1 (FusionGDB2 ID:HG444TG6867)

Fusion Gene Summary for ASPH-TACC1

check button Fusion gene summary
Fusion gene informationFusion gene name: ASPH-TACC1
Fusion gene ID: hg444tg6867
HgeneTgene
Gene symbol

ASPH

TACC1

Gene ID

444

6867

Gene nameaspartate beta-hydroxylasetransforming acidic coiled-coil containing protein 1
SynonymsAAH|BAH|CASQ2BP1|FDLAB|HAAH|JCTN|junctinGa55
Cytomap('ASPH')('TACC1')

8q12.3

8p11.22

Type of geneprotein-codingprotein-coding
Descriptionaspartyl/asparaginyl beta-hydroxylaseA beta H-J-JASP beta-hydroxylasecardiac junctinhumbugjunctatepeptide-aspartate beta-dioxygenasetransforming acidic coiled-coil-containing protein 1gastric cancer antigen Ga55taxin-1
Modification date2020031520200320
UniProtAcc.

O75410

Ensembl transtripts involved in fusion geneENST00000379454, ENST00000522919, 
ENST00000541428, ENST00000523897, 
ENST00000356457, ENST00000379449, 
ENST00000389204, ENST00000445642, 
ENST00000517661, ENST00000517847, 
ENST00000517856, ENST00000517903, 
ENST00000518068, ENST00000522603, 
ENST00000522835, 
Fusion gene scores* DoF score20 X 16 X 7=224018 X 21 X 10=3780
# samples 2123
** MAII scorelog2(21/2240*10)=-3.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(23/3780*10)=-4.03868046816406
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASPH [Title/Abstract] AND TACC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASPH(62531537)-TACC1(38599869), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASPH

GO:0045862

positive regulation of proteolysis

18387192

HgeneASPH

GO:0097202

activation of cysteine-type endopeptidase activity

18387192



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-YC-A89H-01AASPHchr8

62531537

-TACC1chr8

38599869

+


Top

Fusion Gene ORF analysis for ASPH-TACC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000379454ENST00000443286ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-5UTRENST00000379454ENST00000518415ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-5UTRENST00000379454ENST00000520340ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-5UTRENST00000522919ENST00000443286ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-5UTRENST00000522919ENST00000518415ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-5UTRENST00000522919ENST00000520340ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-5UTRENST00000541428ENST00000443286ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-5UTRENST00000541428ENST00000518415ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-5UTRENST00000541428ENST00000520340ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000379454ENST00000276520ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000379454ENST00000317827ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000379454ENST00000330691ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000379454ENST00000348567ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000379454ENST00000379931ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000379454ENST00000519416ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000379454ENST00000520611ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000379454ENST00000520615ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000379454ENST00000520973ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000379454ENST00000522752ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000522919ENST00000276520ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000522919ENST00000317827ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000522919ENST00000330691ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000522919ENST00000348567ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000522919ENST00000379931ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000522919ENST00000519416ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000522919ENST00000520611ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000522919ENST00000520615ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000522919ENST00000520973ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000522919ENST00000522752ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000541428ENST00000276520ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000541428ENST00000317827ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000541428ENST00000330691ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000541428ENST00000348567ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000541428ENST00000379931ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000541428ENST00000519416ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000541428ENST00000520611ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000541428ENST00000520615ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000541428ENST00000520973ASPHchr8

62531537

-TACC1chr8

38599869

+
5CDS-intronENST00000541428ENST00000522752ASPHchr8

62531537

-TACC1chr8

38599869

+
5UTR-5UTRENST00000523897ENST00000443286ASPHchr8

62531537

-TACC1chr8

38599869

+
5UTR-5UTRENST00000523897ENST00000518415ASPHchr8

62531537

-TACC1chr8

38599869

+
5UTR-5UTRENST00000523897ENST00000520340ASPHchr8

62531537

-TACC1chr8

38599869

+
5UTR-intronENST00000523897ENST00000276520ASPHchr8

62531537

-TACC1chr8

38599869

+
5UTR-intronENST00000523897ENST00000317827ASPHchr8

62531537

-TACC1chr8

38599869

+
5UTR-intronENST00000523897ENST00000330691ASPHchr8

62531537

-TACC1chr8

38599869

+
5UTR-intronENST00000523897ENST00000348567ASPHchr8

62531537

-TACC1chr8

38599869

+
5UTR-intronENST00000523897ENST00000379931ASPHchr8

62531537

-TACC1chr8

38599869

+
5UTR-intronENST00000523897ENST00000519416ASPHchr8

62531537

-TACC1chr8

38599869

+
5UTR-intronENST00000523897ENST00000520611ASPHchr8

62531537

-TACC1chr8

38599869

+
5UTR-intronENST00000523897ENST00000520615ASPHchr8

62531537

-TACC1chr8

38599869

+
5UTR-intronENST00000523897ENST00000520973ASPHchr8

62531537

-TACC1chr8

38599869

+
5UTR-intronENST00000523897ENST00000522752ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000356457ENST00000443286ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000356457ENST00000518415ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000356457ENST00000520340ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000379449ENST00000443286ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000379449ENST00000518415ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000379449ENST00000520340ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000389204ENST00000443286ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000389204ENST00000518415ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000389204ENST00000520340ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000445642ENST00000443286ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000445642ENST00000518415ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000445642ENST00000520340ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000517661ENST00000443286ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000517661ENST00000518415ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000517661ENST00000520340ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000517847ENST00000443286ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000517847ENST00000518415ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000517847ENST00000520340ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000517856ENST00000443286ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000517856ENST00000518415ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000517856ENST00000520340ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000517903ENST00000443286ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000517903ENST00000518415ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000517903ENST00000520340ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000518068ENST00000443286ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000518068ENST00000518415ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000518068ENST00000520340ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000522603ENST00000443286ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000522603ENST00000518415ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000522603ENST00000520340ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000522835ENST00000443286ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000522835ENST00000518415ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-5UTRENST00000522835ENST00000520340ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000356457ENST00000276520ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000356457ENST00000317827ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000356457ENST00000330691ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000356457ENST00000348567ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000356457ENST00000379931ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000356457ENST00000519416ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000356457ENST00000520611ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000356457ENST00000520615ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000356457ENST00000520973ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000356457ENST00000522752ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000379449ENST00000276520ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000379449ENST00000317827ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000379449ENST00000330691ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000379449ENST00000348567ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000379449ENST00000379931ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000379449ENST00000519416ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000379449ENST00000520611ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000379449ENST00000520615ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000379449ENST00000520973ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000379449ENST00000522752ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000389204ENST00000276520ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000389204ENST00000317827ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000389204ENST00000330691ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000389204ENST00000348567ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000389204ENST00000379931ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000389204ENST00000519416ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000389204ENST00000520611ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000389204ENST00000520615ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000389204ENST00000520973ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000389204ENST00000522752ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000445642ENST00000276520ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000445642ENST00000317827ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000445642ENST00000330691ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000445642ENST00000348567ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000445642ENST00000379931ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000445642ENST00000519416ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000445642ENST00000520611ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000445642ENST00000520615ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000445642ENST00000520973ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000445642ENST00000522752ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517661ENST00000276520ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517661ENST00000317827ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517661ENST00000330691ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517661ENST00000348567ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517661ENST00000379931ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517661ENST00000519416ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517661ENST00000520611ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517661ENST00000520615ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517661ENST00000520973ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517661ENST00000522752ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517847ENST00000276520ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517847ENST00000317827ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517847ENST00000330691ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517847ENST00000348567ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517847ENST00000379931ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517847ENST00000519416ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517847ENST00000520611ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517847ENST00000520615ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517847ENST00000520973ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517847ENST00000522752ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517856ENST00000276520ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517856ENST00000317827ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517856ENST00000330691ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517856ENST00000348567ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517856ENST00000379931ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517856ENST00000519416ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517856ENST00000520611ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517856ENST00000520615ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517856ENST00000520973ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517856ENST00000522752ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517903ENST00000276520ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517903ENST00000317827ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517903ENST00000330691ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517903ENST00000348567ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517903ENST00000379931ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517903ENST00000519416ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517903ENST00000520611ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517903ENST00000520615ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517903ENST00000520973ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000517903ENST00000522752ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000518068ENST00000276520ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000518068ENST00000317827ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000518068ENST00000330691ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000518068ENST00000348567ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000518068ENST00000379931ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000518068ENST00000519416ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000518068ENST00000520611ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000518068ENST00000520615ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000518068ENST00000520973ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000518068ENST00000522752ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522603ENST00000276520ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522603ENST00000317827ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522603ENST00000330691ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522603ENST00000348567ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522603ENST00000379931ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522603ENST00000519416ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522603ENST00000520611ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522603ENST00000520615ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522603ENST00000520973ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522603ENST00000522752ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522835ENST00000276520ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522835ENST00000317827ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522835ENST00000330691ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522835ENST00000348567ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522835ENST00000379931ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522835ENST00000519416ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522835ENST00000520611ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522835ENST00000520615ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522835ENST00000520973ASPHchr8

62531537

-TACC1chr8

38599869

+
intron-intronENST00000522835ENST00000522752ASPHchr8

62531537

-TACC1chr8

38599869

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ASPH-TACC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ASPHchr862531536-TACC1chr838599868+2.21E-050.99997795
ASPHchr862531536-TACC1chr838599868+2.21E-050.99997795


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ASPH-TACC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:62531537/:38599869)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TACC1

O75410

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ASPH-TACC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ASPH-TACC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASPH-TACC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASPH-TACC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASPHC1832167Ectopia Lentis, Spontaneous Filtering Blebs, and Craniofacial Dysmorphism1CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0206726gliosarcoma1ORPHANET
TgeneC0334588Giant Cell Glioblastoma1ORPHANET