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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASTN1-DHRS7 (FusionGDB2 ID:HG460TG51635)

Fusion Gene Summary for ASTN1-DHRS7

check button Fusion gene summary
Fusion gene informationFusion gene name: ASTN1-DHRS7
Fusion gene ID: hg460tg51635
HgeneTgene
Gene symbol

ASTN1

DHRS7

Gene ID

460

51635

Gene nameastrotactin 1dehydrogenase/reductase 7
SynonymsASTNCGI-86|SDR34C1|retDSR4|retSDR4
Cytomap('ASTN1')('DHRS7')

1q25.2

14q23.1

Type of geneprotein-codingprotein-coding
Descriptionastrotactin-1dehydrogenase/reductase SDR family member 7dehydrogenase/reductase (SDR family) member 7retinal short-chain dehydrogenase/reductase 4short chain dehydrogenase/reductase family 34C member 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000361833, ENST00000367654, 
ENST00000367657, ENST00000424564, 
ENST00000281881, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 2 X 3=18
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ASTN1 [Title/Abstract] AND DHRS7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASTN1(176903288)-DHRS7(60622870), # samples:1
Anticipated loss of major functional domain due to fusion event.ASTN1-DHRS7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASTN1-DHRS7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASTN1-DHRS7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ASTN1-DHRS7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ASTN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DHRS7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-5411-01AASTN1chr1

176903288

-DHRS7chr14

60622870

-


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Fusion Gene ORF analysis for ASTN1-DHRS7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000361833ENST00000536410ASTN1chr1

176903288

-DHRS7chr14

60622870

-
5CDS-5UTRENST00000367654ENST00000536410ASTN1chr1

176903288

-DHRS7chr14

60622870

-
5CDS-5UTRENST00000367657ENST00000536410ASTN1chr1

176903288

-DHRS7chr14

60622870

-
5CDS-5UTRENST00000424564ENST00000536410ASTN1chr1

176903288

-DHRS7chr14

60622870

-
5CDS-intronENST00000361833ENST00000553986ASTN1chr1

176903288

-DHRS7chr14

60622870

-
5CDS-intronENST00000367654ENST00000553986ASTN1chr1

176903288

-DHRS7chr14

60622870

-
5CDS-intronENST00000367657ENST00000553986ASTN1chr1

176903288

-DHRS7chr14

60622870

-
5CDS-intronENST00000424564ENST00000553986ASTN1chr1

176903288

-DHRS7chr14

60622870

-
In-frameENST00000361833ENST00000216500ASTN1chr1

176903288

-DHRS7chr14

60622870

-
In-frameENST00000361833ENST00000557185ASTN1chr1

176903288

-DHRS7chr14

60622870

-
In-frameENST00000367654ENST00000216500ASTN1chr1

176903288

-DHRS7chr14

60622870

-
In-frameENST00000367654ENST00000557185ASTN1chr1

176903288

-DHRS7chr14

60622870

-
In-frameENST00000367657ENST00000216500ASTN1chr1

176903288

-DHRS7chr14

60622870

-
In-frameENST00000367657ENST00000557185ASTN1chr1

176903288

-DHRS7chr14

60622870

-
In-frameENST00000424564ENST00000216500ASTN1chr1

176903288

-DHRS7chr14

60622870

-
In-frameENST00000424564ENST00000557185ASTN1chr1

176903288

-DHRS7chr14

60622870

-
intron-3CDSENST00000281881ENST00000216500ASTN1chr1

176903288

-DHRS7chr14

60622870

-
intron-3CDSENST00000281881ENST00000557185ASTN1chr1

176903288

-DHRS7chr14

60622870

-
intron-5UTRENST00000281881ENST00000536410ASTN1chr1

176903288

-DHRS7chr14

60622870

-
intron-intronENST00000281881ENST00000553986ASTN1chr1

176903288

-DHRS7chr14

60622870

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367657ASTN1chr1176903288-ENST00000216500DHRS7chr1460622870-4595286219137481185
ENST00000367657ASTN1chr1176903288-ENST00000557185DHRS7chr1460622870-3931286219137481185
ENST00000361833ASTN1chr1176903288-ENST00000216500DHRS7chr1460622870-441826851435711185
ENST00000361833ASTN1chr1176903288-ENST00000557185DHRS7chr1460622870-375426851435711185
ENST00000367654ASTN1chr1176903288-ENST00000216500DHRS7chr1460622870-4640290721237931193
ENST00000367654ASTN1chr1176903288-ENST00000557185DHRS7chr1460622870-3976290721237931193
ENST00000424564ASTN1chr1176903288-ENST00000216500DHRS7chr1460622870-44112678735641185
ENST00000424564ASTN1chr1176903288-ENST00000557185DHRS7chr1460622870-37472678735641185

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367657ENST00000216500ASTN1chr1176903288-DHRS7chr1460622870-0.0008853650.9991146
ENST00000367657ENST00000557185ASTN1chr1176903288-DHRS7chr1460622870-0.0015791780.99842083
ENST00000361833ENST00000216500ASTN1chr1176903288-DHRS7chr1460622870-0.0007107390.9992893
ENST00000361833ENST00000557185ASTN1chr1176903288-DHRS7chr1460622870-0.0012167020.9987833
ENST00000367654ENST00000216500ASTN1chr1176903288-DHRS7chr1460622870-0.0008624220.9991375
ENST00000367654ENST00000557185ASTN1chr1176903288-DHRS7chr1460622870-0.0015569140.99844307
ENST00000424564ENST00000216500ASTN1chr1176903288-DHRS7chr1460622870-0.0006992850.9993007
ENST00000424564ENST00000557185ASTN1chr1176903288-DHRS7chr1460622870-0.0011981510.9988018

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Fusion Genomic Features for ASTN1-DHRS7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ASTN1-DHRS7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:176903288/chr14:60622870)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASTN1chr1:176903288chr14:60622870ENST00000361833-1623459_5078901295.0DomainNote=EGF-like 1
HgeneASTN1chr1:176903288chr14:60622870ENST00000361833-1623608_6528901295.0DomainNote=EGF-like 2
HgeneASTN1chr1:176903288chr14:60622870ENST00000361833-1623656_7088901295.0DomainNote=EGF-like 3
HgeneASTN1chr1:176903288chr14:60622870ENST00000367654-1623459_5078981303.0DomainNote=EGF-like 1
HgeneASTN1chr1:176903288chr14:60622870ENST00000367654-1623608_6528981303.0DomainNote=EGF-like 2
HgeneASTN1chr1:176903288chr14:60622870ENST00000367654-1623656_7088981303.0DomainNote=EGF-like 3
HgeneASTN1chr1:176903288chr14:60622870ENST00000424564-1622459_5078901217.0DomainNote=EGF-like 1
HgeneASTN1chr1:176903288chr14:60622870ENST00000424564-1622608_6528901217.0DomainNote=EGF-like 2
HgeneASTN1chr1:176903288chr14:60622870ENST00000424564-1622656_7088901217.0DomainNote=EGF-like 3
HgeneASTN1chr1:176903288chr14:60622870ENST00000361833-1623175_3838901295.0Topological domainCytoplasmic
HgeneASTN1chr1:176903288chr14:60622870ENST00000361833-162322_1538901295.0Topological domainExtracellular
HgeneASTN1chr1:176903288chr14:60622870ENST00000367654-1623175_3838981303.0Topological domainCytoplasmic
HgeneASTN1chr1:176903288chr14:60622870ENST00000367654-162322_1538981303.0Topological domainExtracellular
HgeneASTN1chr1:176903288chr14:60622870ENST00000424564-1622175_3838901217.0Topological domainCytoplasmic
HgeneASTN1chr1:176903288chr14:60622870ENST00000424564-162222_1538901217.0Topological domainExtracellular
HgeneASTN1chr1:176903288chr14:60622870ENST00000361833-1623154_1748901295.0TransmembraneHelical
HgeneASTN1chr1:176903288chr14:60622870ENST00000361833-1623384_4028901295.0TransmembraneHelical
HgeneASTN1chr1:176903288chr14:60622870ENST00000367654-1623154_1748981303.0TransmembraneHelical
HgeneASTN1chr1:176903288chr14:60622870ENST00000367654-1623384_4028981303.0TransmembraneHelical
HgeneASTN1chr1:176903288chr14:60622870ENST00000424564-1622154_1748901217.0TransmembraneHelical
HgeneASTN1chr1:176903288chr14:60622870ENST00000424564-1622384_4028901217.0TransmembraneHelical
TgeneDHRS7chr1:176903288chr14:60622870ENST000002165001854_7844340.0Nucleotide bindingNAD
TgeneDHRS7chr1:176903288chr14:60622870ENST000005364100754_780290.0Nucleotide bindingNAD
TgeneDHRS7chr1:176903288chr14:60622870ENST000005571850754_7844340.0Nucleotide bindingNAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASTN1chr1:176903288chr14:60622870ENST00000361833-16231030_11458901295.0DomainNote=Fibronectin type-III
HgeneASTN1chr1:176903288chr14:60622870ENST00000367654-16231030_11458981303.0DomainNote=Fibronectin type-III
HgeneASTN1chr1:176903288chr14:60622870ENST00000424564-16221030_11458901217.0DomainNote=Fibronectin type-III
HgeneASTN1chr1:176903288chr14:60622870ENST00000361833-1623403_13028901295.0Topological domainExtracellular
HgeneASTN1chr1:176903288chr14:60622870ENST00000367654-1623403_13028981303.0Topological domainExtracellular
HgeneASTN1chr1:176903288chr14:60622870ENST00000424564-1622403_13028901217.0Topological domainExtracellular


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Fusion Gene Sequence for ASTN1-DHRS7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7262_7262_1_ASTN1-DHRS7_ASTN1_chr1_176903288_ENST00000361833_DHRS7_chr14_60622870_ENST00000216500_length(transcript)=4418nt_BP=2685nt
GGCCGGGGCTCAAGATGGCTTTAGCCGGGCTCTGCGCCCTGCTCGCCTGCTGCTGGGGGCCGGCGGCGGTGCTGGCCACGGCCGCCGGCG
ACGTGGATCCATCCAAGGAGCTGGAGTGCAAGCTCAAAAGCATCACGGTGTCGGCACTGCCCTTCCTGCGCGAGAACGACCTGAGCATCA
TGCACAGCCCCTCGGCCTCGGAGCCCAAGCTCCTCTTCTCGGTGCGCAACGACTTCCCGGGAGAAATGGTCGTGGTGGACGACCTGGAGA
ACACGGAGCTGCCCTACTTCGTGCTGGAGATCTCAGGGAACACAGAGGATATCCCTTTGGTGCGCTGGAGGCAGCAGTGGCTGGAGAATG
GCACTTTGCTTTTTCACATTCATCACCAAGATGGTGCCCCAAGCCTTCCTGGACAAGACCCCACTGAAGAACCCCAACATGAGTCGGCAG
AAGAGGAGCTGAGGATCCTCCACATCTCAGTCATGGGTGGCATGATCGCTCTGCTGCTGTCCATCTTGTGCCTGGTGATGATCCTGTATA
CTCGCCGGCGCTGGTGCAAACGCCGCCGGGTCCCGCAGCCCCAGAAGAGTGCCAGTGCTGAGGCAGCCAATGAGATTCACTACATTCCTT
CTGTGCTGATCGGCGGGCACGGACGGGAGAGCCTGCGCAATGCCCGCGTGCAGGGCCACAACTCCAGTGGCACCCTGAGCATCCGGGAGA
CACCTATCCTGGACGGCTATGAGTATGACATCACTGATCTGCGCCACCATCTGCAGAGGGAGTGCATGAACGGAGGGGAGGACTTTGCCA
GCCAGGTCACGCGCACCCTCGACTCCCTGCAGGGCTGCAATGAAAAGTCGGGGATGGACCTCACACCAGGAAGTGACAATGCCAAGCTGT
CACTGATGAACAAGTATAAAGATAATATTATAGCCACTAGCCCTGTGGACTCCAACCACCAGCAAGCCACCCTTCTCTCTCACACCTCCA
GCAGCCAGAGAAAGCGGATCAACAACAAAGCAAGAGCTGGTTCCGCCTTCTTGAACCCTGAAGGGGATTCTGGCACAGAGGCAGAAAACG
ACCCCCAGCTGACCTTTTACACGGATCCTTCAAGGAGCAGGAGGCGTAGTAGAGTGGGTTCTCCCCGAAGTCCTGTGAATAAGACCACCT
TGACCCTGATCAGCATCACCAGCTGTGTGATTGGCCTCGTGTGCTCCTCTCACGTCAACTGCCCTCTCGTTGTCAAGATCACCCTGCATG
TCCCTGAGCACCTGATTGCTGATGGGAGCCGCTTCATCTTGCTGGAGGGGAGCCAGCTGGATGCCAGTGACTGGCTGAACCCTGCCCAAG
TGGTTCTCTTCTCTCAGCAGAACTCCAGCGGACCCTGGGCCATGGACCTCTGTGCCCGGCGGCTCCTGGACCCCTGTGAACACCAATGTG
ACCCCGAAACTGGGGAATGCCTCTGCTATGAAGGCTACATGAAGGATCCAGTACATAAGCACCTTTGCATTCGGAACGAATGGGGGACAA
ACCAGGGGCCATGGCCTTACACAATATTTCAGCGAGGCTTTGACCTGGTTTTGGGAGAGCAGCCCTCTGATAAAATATTTAGATTCACCT
ACACTCTTGGGGAGGGCATGTGGTTGCCCCTCAGCAAGAGCTTTGTGATTCCACCAGCCGAACTGGCCATCAATCCATCAGCAAAGTGCA
AGACGGACATGACTGTGATGGAGGATGCTGTGGAGGTCAGAGAGGAGCTGATGACTTCATCCTCCTTCGACAGCCTGGAGGTTCTCTTAG
ATTCCTTTGGGCCGGTGCGCGACTGCAGCAAAGATAACGGGGGCTGCAGTAAGAATTTCCGCTGTATTTCAGATCGCAAGCTGGACTCCA
CTGGTTGCGTGTGCCCATCTGGACTCAGTCCCATGAAGGACAGCTCTGGCTGCTATGACCGCCACATCGGGGTGGACTGTTCCGACGGCT
TCAACGGCGGCTGTGAGCAGCTGTGCCTCCAGCAGATGGCGCCCTTCCCGGACGACCCCACCTTGTATAACATCCTCATGTTCTGTGGGT
GCATCGAGGACTACAAGCTTGGTGTGGATGGACGCTCTTGCCAACTCATCACGGAGACCTGTCCAGAGGGAAGTGACTGTGGGGAAAGCA
GGGAGCTTCCCATGAACCAGACCCTCTTTGGGGAGATGTTCTTTGGTTACAACAACCATTCCAAGGAAGTGGCTGCCGGACAGGTGCTGA
AAGGAACATTCAGGCAAAACAACTTTGCTCGTGGTTTAGACCAGCAACTGCCAGATGGTCTTGTGGTGGCCACTGTGCCCCTGGAGAATC
AATGCCTAGAGGAGATCTCGGAGCCCACCCCTGACCCTGACTTCCTGACTGGGATGGTGAACTTCAGTGAAGTGTCTGGGTACCCTGTGC
TGCAGCACTGGAAGGTCCGGTCTGTGATGTACCACATCAAACTCAACCAAGTGGCCATCTCTCAGGCCCTCAGCAATGCTCTCCACTCGC
TGGATGGGGCTACATCTCGTGCAGATTTTGTGGCGCTGTTGGACCAGTTCGGCAACCATTACATCCAGGAAGCTATCTACGGCTTTGAGG
AGTCCTGTTCTATCTGGTACCCAAACAAGCAGGTCCAGCGGCGACTCTGGCTGGAGTATGAAGACATCAGTAAAGAATGGGAGCTGACTG
ATATGGTGGTGTGGGTGACTGGAGCCTCGAGTGGAATTGGTGAGGAGCTGGCTTACCAGTTGTCTAAACTAGGAGTTTCTCTTGTGCTGT
CAGCCAGAAGAGTGCATGAGCTGGAAAGGGTGAAAAGAAGATGCCTAGAGAATGGCAATTTAAAAGAAAAAGATATACTTGTTTTGCCCC
TTGACCTGACCGACACTGGTTCCCATGAAGCGGCTACCAAAGCTGTTCTCCAGGAGTTTGGTAGAATCGACATTCTGGTCAACAATGGTG
GAATGTCCCAGCGTTCTCTGTGCATGGATACCAGCTTGGATGTCTACAGAAAGCTAATAGAGCTTAACTACTTAGGGACGGTGTCCTTGA
CAAAATGTGTTCTGCCTCACATGATCGAGAGGAAGCAAGGAAAGATTGTTACTGTGAATAGCATCCTGGGTATCATATCTGTACCTCTTT
CCATTGGATACTGTGCTAGCAAGCATGCTCTCCGGGGTTTTTTTAATGGCCTTCGAACAGAACTTGCCACATACCCAGGTATAATAGTTT
CTAACATTTGCCCAGGACCTGTGCAATCAAATATTGTGGAGAATTCCCTAGCTGGAGAAGTCACAAAGACTATAGGCAATAATGGAGACC
AGTCCCACAAGATGACAACCAGTCGTTGTGTGCGGCTGATGTTAATCAGCATGGCCAATGATTTGAAAGAAGTTTGGATCTCAGAACAAC
CTTTCTTGTTAGTAACATATTTGTGGCAATACATGCCAACCTGGGCCTGGTGGATAACCAACAAGATGGGGAAGAAAAGGATTGAGAACT
TTAAGAGTGGTGTGGATGCAGACTCTTCTTATTTTAAAATCTTTAAGACAAAACATGACTGAAAAGAGCACCTGTACTTTTCAAGCCACT
GGAGGGAGAAATGGAAAACATGAAAACAGCAATCTTCTTATGCTTCTGAATAATCAAAGACTAATTTGTGATTTTACTTTTTAATAGATA
TGACTTTGCTTCCAACATGGAATGAAATAAAAAATAAATAATAAAAGATTGCCATGAATCTTGCAAAAAAGGTATTAACTCATACTATAT
TCTTGGATAAAATAACCTTTTAAAATACTTTAGCACATATGCTTAAAATCTAAGTTAACAGATTTGTCTTAGTCCATTTGTGCTGCTATA
ACAAAATACCACAGATTTGGTAATTTATAAACAACAGAAATCTGTTTTTCCTGGCTCTTGAGGCTGGGAATTCCAAGACCAATGCACCAG
CAGAATTAGTGTCTGGTGAAGGCTGATCTCTGCTTCCAAGATGGCACCTCATTGCTGCATCCTCCACAGTGGAGGAATGTATGTCCTCAC
ATGGTGGAAGGGACAGAAGGGAAAGAGGAGCAAAATGCTTTCAAAAGAGCATTTAATCTCATTCATTACTCAGTCACCTCTTAAAGGCCA
CATCCTTTAATACTGTTGCTTTGGGGATTAAGTTTCGACATGAATTTTGGAGGGGACAAAAACATCCAAACCATAGCAACATAAATGTAT
AGAATATTTCACACAAAGCAGAGTGCTGGGTAATGACCAGATATAAAGAAGTATTTGAAATGACCTTACCTCCAAGATGCTTATACTCTT
AGAAAAGTTGACAGGTACAGATGGCTGTAATTTGAAGCAGCAGGTAGGATTCATTGCACCTATTATTCATTAAACACCTGTTGTATGTCT

>7262_7262_1_ASTN1-DHRS7_ASTN1_chr1_176903288_ENST00000361833_DHRS7_chr14_60622870_ENST00000216500_length(amino acids)=1185AA_BP=888
MALAGLCALLACCWGPAAVLATAAGDVDPSKELECKLKSITVSALPFLRENDLSIMHSPSASEPKLLFSVRNDFPGEMVVVDDLENTELP
YFVLEISGNTEDIPLVRWRQQWLENGTLLFHIHHQDGAPSLPGQDPTEEPQHESAEEELRILHISVMGGMIALLLSILCLVMILYTRRRW
CKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQRECMNGGEDFASQVTR
TLDSLQGCNEKSGMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKRINNKARAGSAFLNPEGDSGTEAENDPQLT
FYTDPSRSRRRSRVGSPRSPVNKTTLTLISITSCVIGLVCSSHVNCPLVVKITLHVPEHLIADGSRFILLEGSQLDASDWLNPAQVVLFS
QQNSSGPWAMDLCARRLLDPCEHQCDPETGECLCYEGYMKDPVHKHLCIRNEWGTNQGPWPYTIFQRGFDLVLGEQPSDKIFRFTYTLGE
GMWLPLSKSFVIPPAELAINPSAKCKTDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSKDNGGCSKNFRCISDRKLDSTGCVC
PSGLSPMKDSSGCYDRHIGVDCSDGFNGGCEQLCLQQMAPFPDDPTLYNILMFCGCIEDYKLGVDGRSCQLITETCPEGSDCGESRELPM
NQTLFGEMFFGYNNHSKEVAAGQVLKGTFRQNNFARGLDQQLPDGLVVATVPLENQCLEEISEPTPDPDFLTGMVNFSEVSGYPVLQHWK
VRSVMYHIKLNQVAISQALSNALHSLDGATSRADFVALLDQFGNHYIQEAIYGFEESCSIWYPNKQVQRRLWLEYEDISKEWELTDMVVW
VTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQR
SLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICP
GPVQSNIVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQYMPTWAWWITNKMGKKRIENFKSGV

--------------------------------------------------------------
>7262_7262_2_ASTN1-DHRS7_ASTN1_chr1_176903288_ENST00000361833_DHRS7_chr14_60622870_ENST00000557185_length(transcript)=3754nt_BP=2685nt
GGCCGGGGCTCAAGATGGCTTTAGCCGGGCTCTGCGCCCTGCTCGCCTGCTGCTGGGGGCCGGCGGCGGTGCTGGCCACGGCCGCCGGCG
ACGTGGATCCATCCAAGGAGCTGGAGTGCAAGCTCAAAAGCATCACGGTGTCGGCACTGCCCTTCCTGCGCGAGAACGACCTGAGCATCA
TGCACAGCCCCTCGGCCTCGGAGCCCAAGCTCCTCTTCTCGGTGCGCAACGACTTCCCGGGAGAAATGGTCGTGGTGGACGACCTGGAGA
ACACGGAGCTGCCCTACTTCGTGCTGGAGATCTCAGGGAACACAGAGGATATCCCTTTGGTGCGCTGGAGGCAGCAGTGGCTGGAGAATG
GCACTTTGCTTTTTCACATTCATCACCAAGATGGTGCCCCAAGCCTTCCTGGACAAGACCCCACTGAAGAACCCCAACATGAGTCGGCAG
AAGAGGAGCTGAGGATCCTCCACATCTCAGTCATGGGTGGCATGATCGCTCTGCTGCTGTCCATCTTGTGCCTGGTGATGATCCTGTATA
CTCGCCGGCGCTGGTGCAAACGCCGCCGGGTCCCGCAGCCCCAGAAGAGTGCCAGTGCTGAGGCAGCCAATGAGATTCACTACATTCCTT
CTGTGCTGATCGGCGGGCACGGACGGGAGAGCCTGCGCAATGCCCGCGTGCAGGGCCACAACTCCAGTGGCACCCTGAGCATCCGGGAGA
CACCTATCCTGGACGGCTATGAGTATGACATCACTGATCTGCGCCACCATCTGCAGAGGGAGTGCATGAACGGAGGGGAGGACTTTGCCA
GCCAGGTCACGCGCACCCTCGACTCCCTGCAGGGCTGCAATGAAAAGTCGGGGATGGACCTCACACCAGGAAGTGACAATGCCAAGCTGT
CACTGATGAACAAGTATAAAGATAATATTATAGCCACTAGCCCTGTGGACTCCAACCACCAGCAAGCCACCCTTCTCTCTCACACCTCCA
GCAGCCAGAGAAAGCGGATCAACAACAAAGCAAGAGCTGGTTCCGCCTTCTTGAACCCTGAAGGGGATTCTGGCACAGAGGCAGAAAACG
ACCCCCAGCTGACCTTTTACACGGATCCTTCAAGGAGCAGGAGGCGTAGTAGAGTGGGTTCTCCCCGAAGTCCTGTGAATAAGACCACCT
TGACCCTGATCAGCATCACCAGCTGTGTGATTGGCCTCGTGTGCTCCTCTCACGTCAACTGCCCTCTCGTTGTCAAGATCACCCTGCATG
TCCCTGAGCACCTGATTGCTGATGGGAGCCGCTTCATCTTGCTGGAGGGGAGCCAGCTGGATGCCAGTGACTGGCTGAACCCTGCCCAAG
TGGTTCTCTTCTCTCAGCAGAACTCCAGCGGACCCTGGGCCATGGACCTCTGTGCCCGGCGGCTCCTGGACCCCTGTGAACACCAATGTG
ACCCCGAAACTGGGGAATGCCTCTGCTATGAAGGCTACATGAAGGATCCAGTACATAAGCACCTTTGCATTCGGAACGAATGGGGGACAA
ACCAGGGGCCATGGCCTTACACAATATTTCAGCGAGGCTTTGACCTGGTTTTGGGAGAGCAGCCCTCTGATAAAATATTTAGATTCACCT
ACACTCTTGGGGAGGGCATGTGGTTGCCCCTCAGCAAGAGCTTTGTGATTCCACCAGCCGAACTGGCCATCAATCCATCAGCAAAGTGCA
AGACGGACATGACTGTGATGGAGGATGCTGTGGAGGTCAGAGAGGAGCTGATGACTTCATCCTCCTTCGACAGCCTGGAGGTTCTCTTAG
ATTCCTTTGGGCCGGTGCGCGACTGCAGCAAAGATAACGGGGGCTGCAGTAAGAATTTCCGCTGTATTTCAGATCGCAAGCTGGACTCCA
CTGGTTGCGTGTGCCCATCTGGACTCAGTCCCATGAAGGACAGCTCTGGCTGCTATGACCGCCACATCGGGGTGGACTGTTCCGACGGCT
TCAACGGCGGCTGTGAGCAGCTGTGCCTCCAGCAGATGGCGCCCTTCCCGGACGACCCCACCTTGTATAACATCCTCATGTTCTGTGGGT
GCATCGAGGACTACAAGCTTGGTGTGGATGGACGCTCTTGCCAACTCATCACGGAGACCTGTCCAGAGGGAAGTGACTGTGGGGAAAGCA
GGGAGCTTCCCATGAACCAGACCCTCTTTGGGGAGATGTTCTTTGGTTACAACAACCATTCCAAGGAAGTGGCTGCCGGACAGGTGCTGA
AAGGAACATTCAGGCAAAACAACTTTGCTCGTGGTTTAGACCAGCAACTGCCAGATGGTCTTGTGGTGGCCACTGTGCCCCTGGAGAATC
AATGCCTAGAGGAGATCTCGGAGCCCACCCCTGACCCTGACTTCCTGACTGGGATGGTGAACTTCAGTGAAGTGTCTGGGTACCCTGTGC
TGCAGCACTGGAAGGTCCGGTCTGTGATGTACCACATCAAACTCAACCAAGTGGCCATCTCTCAGGCCCTCAGCAATGCTCTCCACTCGC
TGGATGGGGCTACATCTCGTGCAGATTTTGTGGCGCTGTTGGACCAGTTCGGCAACCATTACATCCAGGAAGCTATCTACGGCTTTGAGG
AGTCCTGTTCTATCTGGTACCCAAACAAGCAGGTCCAGCGGCGACTCTGGCTGGAGTATGAAGACATCAGTAAAGAATGGGAGCTGACTG
ATATGGTGGTGTGGGTGACTGGAGCCTCGAGTGGAATTGGTGAGGAGCTGGCTTACCAGTTGTCTAAACTAGGAGTTTCTCTTGTGCTGT
CAGCCAGAAGAGTGCATGAGCTGGAAAGGGTGAAAAGAAGATGCCTAGAGAATGGCAATTTAAAAGAAAAAGATATACTTGTTTTGCCCC
TTGACCTGACCGACACTGGTTCCCATGAAGCGGCTACCAAAGCTGTTCTCCAGGAGTTTGGTAGAATCGACATTCTGGTCAACAATGGTG
GAATGTCCCAGCGTTCTCTGTGCATGGATACCAGCTTGGATGTCTACAGAAAGCTAATAGAGCTTAACTACTTAGGGACGGTGTCCTTGA
CAAAATGTGTTCTGCCTCACATGATCGAGAGGAAGCAAGGAAAGATTGTTACTGTGAATAGCATCCTGGGTATCATATCTGTACCTCTTT
CCATTGGATACTGTGCTAGCAAGCATGCTCTCCGGGGTTTTTTTAATGGCCTTCGAACAGAACTTGCCACATACCCAGGTATAATAGTTT
CTAACATTTGCCCAGGACCTGTGCAATCAAATATTGTGGAGAATTCCCTAGCTGGAGAAGTCACAAAGACTATAGGCAATAATGGAGACC
AGTCCCACAAGATGACAACCAGTCGTTGTGTGCGGCTGATGTTAATCAGCATGGCCAATGATTTGAAAGAAGTTTGGATCTCAGAACAAC
CTTTCTTGTTAGTAACATATTTGTGGCAATACATGCCAACCTGGGCCTGGTGGATAACCAACAAGATGGGGAAGAAAAGGATTGAGAACT
TTAAGAGTGGTGTGGATGCAGACTCTTCTTATTTTAAAATCTTTAAGACAAAACATGACTGAAAAGAGCACCTGTACTTTTCAAGCCACT
GGAGGGAGAAATGGAAAACATGAAAACAGCAATCTTCTTATGCTTCTGAATAATCAAAGACTAATTTGTGATTTTACTTTTTAATAGATA

>7262_7262_2_ASTN1-DHRS7_ASTN1_chr1_176903288_ENST00000361833_DHRS7_chr14_60622870_ENST00000557185_length(amino acids)=1185AA_BP=888
MALAGLCALLACCWGPAAVLATAAGDVDPSKELECKLKSITVSALPFLRENDLSIMHSPSASEPKLLFSVRNDFPGEMVVVDDLENTELP
YFVLEISGNTEDIPLVRWRQQWLENGTLLFHIHHQDGAPSLPGQDPTEEPQHESAEEELRILHISVMGGMIALLLSILCLVMILYTRRRW
CKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQRECMNGGEDFASQVTR
TLDSLQGCNEKSGMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKRINNKARAGSAFLNPEGDSGTEAENDPQLT
FYTDPSRSRRRSRVGSPRSPVNKTTLTLISITSCVIGLVCSSHVNCPLVVKITLHVPEHLIADGSRFILLEGSQLDASDWLNPAQVVLFS
QQNSSGPWAMDLCARRLLDPCEHQCDPETGECLCYEGYMKDPVHKHLCIRNEWGTNQGPWPYTIFQRGFDLVLGEQPSDKIFRFTYTLGE
GMWLPLSKSFVIPPAELAINPSAKCKTDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSKDNGGCSKNFRCISDRKLDSTGCVC
PSGLSPMKDSSGCYDRHIGVDCSDGFNGGCEQLCLQQMAPFPDDPTLYNILMFCGCIEDYKLGVDGRSCQLITETCPEGSDCGESRELPM
NQTLFGEMFFGYNNHSKEVAAGQVLKGTFRQNNFARGLDQQLPDGLVVATVPLENQCLEEISEPTPDPDFLTGMVNFSEVSGYPVLQHWK
VRSVMYHIKLNQVAISQALSNALHSLDGATSRADFVALLDQFGNHYIQEAIYGFEESCSIWYPNKQVQRRLWLEYEDISKEWELTDMVVW
VTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQR
SLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICP
GPVQSNIVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQYMPTWAWWITNKMGKKRIENFKSGV

--------------------------------------------------------------
>7262_7262_3_ASTN1-DHRS7_ASTN1_chr1_176903288_ENST00000367654_DHRS7_chr14_60622870_ENST00000216500_length(transcript)=4640nt_BP=2907nt
GCTCCGGGAAACAAAGAATCCGGGGCTCTCCAGACATCAGAGCTTAAACCCAGGACTCTGCAAGCGGCATCTCATTCCGGGGTCCAGGGC
TCTCCCGGCTCTCCATCCCCTCCCTAACCTCCCCCGCCTCCCGCGCTCGCTCCCTCGCTCCCTCCCCGCTCGCTTCCTCCCCCACCATCG
CAGCGCTAGGAGGAAGGCGGCCGGGGCTCAAGATGGCTTTAGCCGGGCTCTGCGCCCTGCTCGCCTGCTGCTGGGGGCCGGCGGCGGTGC
TGGCCACGGCCGCCGGCGACGTGGATCCATCCAAGGAGCTGGAGTGCAAGCTCAAAAGCATCACGGTGTCGGCACTGCCCTTCCTGCGCG
AGAACGACCTGAGCATCATGCACAGCCCCTCGGCCTCGGAGCCCAAGCTCCTCTTCTCGGTGCGCAACGACTTCCCGGGAGAAATGGTCG
TGGTGGACGACCTGGAGAACACGGAGCTGCCCTACTTCGTGCTGGAGATCTCAGGGAACACAGAGGATATCCCTTTGGTGCGCTGGAGGC
AGCAGTGGCTGGAGAATGGCACTTTGCTTTTTCACATTCATCACCAAGATGGTGCCCCAAGCCTTCCTGGACAAGACCCCACTGAAGAAC
CCCAACATGAGTCGGCAGAAGAGGAGCTGAGGATCCTCCACATCTCAGTCATGGGTGGCATGATCGCTCTGCTGCTGTCCATCTTGTGCC
TGGTGATGATCCTGTATACTCGCCGGCGCTGGTGCAAACGCCGCCGGGTCCCGCAGCCCCAGAAGAGTGCCAGTGCTGAGGCAGCCAATG
AGATTCACTACATTCCTTCTGTGCTGATCGGCGGGCACGGACGGGAGAGCCTGCGCAATGCCCGCGTGCAGGGCCACAACTCCAGTGGCA
CCCTGAGCATCCGGGAGACACCTATCCTGGACGGCTATGAGTATGACATCACTGATCTGCGCCACCATCTGCAGAGGGAGTGCATGAACG
GAGGGGAGGACTTTGCCAGCCAGGTCACGCGCACCCTCGACTCCCTGCAGGGCTGCAATGAAAAGTCGGGGATGGACCTCACACCAGGAA
GTGACAATGCCAAGCTGTCACTGATGAACAAGTATAAAGATAATATTATAGCCACTAGCCCTGTGGACTCCAACCACCAGCAAGCCACCC
TTCTCTCTCACACCTCCAGCAGCCAGAGAAAGCGGATCAACAACAAAGCAAGAGCTGGTTCCGCCTTCTTGAACCCTGAAGGGGATTCTG
GCACAGAGGCAGAAAACGACCCCCAGCTGACCTTTTACACGGATCCTTCAAGGAGCAGGAGGCGTAGTAGAGTGGGTTCTCCCCGAAGTC
CTGTGAATAAGACCACCTTGACCCTGATCAGCATCACCAGCTGTGTGATTGGCCTCGTGTGCTCCTCTCACGTCAACTGCCCTCTCGTTG
TCAAGATCACCCTGCATGTCCCTGAGCACCTGATTGCTGATGGGAGCCGCTTCATCTTGCTGGAGGGGAGCCAGCTGGATGCCAGTGACT
GGCTGAACCCTGCCCAAGTGGTTCTCTTCTCTCAGCAGAACTCCAGCGGACCCTGGGCCATGGACCTCTGTGCCCGGCGGCTCCTGGACC
CCTGTGAACACCAATGTGACCCCGAAACTGGTAGGCGGGAGCACCGGGCAGCGGGGGAATGCCTCTGCTATGAAGGCTACATGAAGGATC
CAGTACATAAGCACCTTTGCATTCGGAACGAATGGGGGACAAACCAGGGGCCATGGCCTTACACAATATTTCAGCGAGGCTTTGACCTGG
TTTTGGGAGAGCAGCCCTCTGATAAAATATTTAGATTCACCTACACTCTTGGGGAGGGCATGTGGTTGCCCCTCAGCAAGAGCTTTGTGA
TTCCACCAGCCGAACTGGCCATCAATCCATCAGCAAAGTGCAAGACGGACATGACTGTGATGGAGGATGCTGTGGAGGTCAGAGAGGAGC
TGATGACTTCATCCTCCTTCGACAGCCTGGAGGTTCTCTTAGATTCCTTTGGGCCGGTGCGCGACTGCAGCAAAGATAACGGGGGCTGCA
GTAAGAATTTCCGCTGTATTTCAGATCGCAAGCTGGACTCCACTGGTTGCGTGTGCCCATCTGGACTCAGTCCCATGAAGGACAGCTCTG
GCTGCTATGACCGCCACATCGGGGTGGACTGTTCCGACGGCTTCAACGGCGGCTGTGAGCAGCTGTGCCTCCAGCAGATGGCGCCCTTCC
CGGACGACCCCACCTTGTATAACATCCTCATGTTCTGTGGGTGCATCGAGGACTACAAGCTTGGTGTGGATGGACGCTCTTGCCAACTCA
TCACGGAGACCTGTCCAGAGGGAAGTGACTGTGGGGAAAGCAGGGAGCTTCCCATGAACCAGACCCTCTTTGGGGAGATGTTCTTTGGTT
ACAACAACCATTCCAAGGAAGTGGCTGCCGGACAGGTGCTGAAAGGAACATTCAGGCAAAACAACTTTGCTCGTGGTTTAGACCAGCAAC
TGCCAGATGGTCTTGTGGTGGCCACTGTGCCCCTGGAGAATCAATGCCTAGAGGAGATCTCGGAGCCCACCCCTGACCCTGACTTCCTGA
CTGGGATGGTGAACTTCAGTGAAGTGTCTGGGTACCCTGTGCTGCAGCACTGGAAGGTCCGGTCTGTGATGTACCACATCAAACTCAACC
AAGTGGCCATCTCTCAGGCCCTCAGCAATGCTCTCCACTCGCTGGATGGGGCTACATCTCGTGCAGATTTTGTGGCGCTGTTGGACCAGT
TCGGCAACCATTACATCCAGGAAGCTATCTACGGCTTTGAGGAGTCCTGTTCTATCTGGTACCCAAACAAGCAGGTCCAGCGGCGACTCT
GGCTGGAGTATGAAGACATCAGTAAAGAATGGGAGCTGACTGATATGGTGGTGTGGGTGACTGGAGCCTCGAGTGGAATTGGTGAGGAGC
TGGCTTACCAGTTGTCTAAACTAGGAGTTTCTCTTGTGCTGTCAGCCAGAAGAGTGCATGAGCTGGAAAGGGTGAAAAGAAGATGCCTAG
AGAATGGCAATTTAAAAGAAAAAGATATACTTGTTTTGCCCCTTGACCTGACCGACACTGGTTCCCATGAAGCGGCTACCAAAGCTGTTC
TCCAGGAGTTTGGTAGAATCGACATTCTGGTCAACAATGGTGGAATGTCCCAGCGTTCTCTGTGCATGGATACCAGCTTGGATGTCTACA
GAAAGCTAATAGAGCTTAACTACTTAGGGACGGTGTCCTTGACAAAATGTGTTCTGCCTCACATGATCGAGAGGAAGCAAGGAAAGATTG
TTACTGTGAATAGCATCCTGGGTATCATATCTGTACCTCTTTCCATTGGATACTGTGCTAGCAAGCATGCTCTCCGGGGTTTTTTTAATG
GCCTTCGAACAGAACTTGCCACATACCCAGGTATAATAGTTTCTAACATTTGCCCAGGACCTGTGCAATCAAATATTGTGGAGAATTCCC
TAGCTGGAGAAGTCACAAAGACTATAGGCAATAATGGAGACCAGTCCCACAAGATGACAACCAGTCGTTGTGTGCGGCTGATGTTAATCA
GCATGGCCAATGATTTGAAAGAAGTTTGGATCTCAGAACAACCTTTCTTGTTAGTAACATATTTGTGGCAATACATGCCAACCTGGGCCT
GGTGGATAACCAACAAGATGGGGAAGAAAAGGATTGAGAACTTTAAGAGTGGTGTGGATGCAGACTCTTCTTATTTTAAAATCTTTAAGA
CAAAACATGACTGAAAAGAGCACCTGTACTTTTCAAGCCACTGGAGGGAGAAATGGAAAACATGAAAACAGCAATCTTCTTATGCTTCTG
AATAATCAAAGACTAATTTGTGATTTTACTTTTTAATAGATATGACTTTGCTTCCAACATGGAATGAAATAAAAAATAAATAATAAAAGA
TTGCCATGAATCTTGCAAAAAAGGTATTAACTCATACTATATTCTTGGATAAAATAACCTTTTAAAATACTTTAGCACATATGCTTAAAA
TCTAAGTTAACAGATTTGTCTTAGTCCATTTGTGCTGCTATAACAAAATACCACAGATTTGGTAATTTATAAACAACAGAAATCTGTTTT
TCCTGGCTCTTGAGGCTGGGAATTCCAAGACCAATGCACCAGCAGAATTAGTGTCTGGTGAAGGCTGATCTCTGCTTCCAAGATGGCACC
TCATTGCTGCATCCTCCACAGTGGAGGAATGTATGTCCTCACATGGTGGAAGGGACAGAAGGGAAAGAGGAGCAAAATGCTTTCAAAAGA
GCATTTAATCTCATTCATTACTCAGTCACCTCTTAAAGGCCACATCCTTTAATACTGTTGCTTTGGGGATTAAGTTTCGACATGAATTTT
GGAGGGGACAAAAACATCCAAACCATAGCAACATAAATGTATAGAATATTTCACACAAAGCAGAGTGCTGGGTAATGACCAGATATAAAG
AAGTATTTGAAATGACCTTACCTCCAAGATGCTTATACTCTTAGAAAAGTTGACAGGTACAGATGGCTGTAATTTGAAGCAGCAGGTAGG

>7262_7262_3_ASTN1-DHRS7_ASTN1_chr1_176903288_ENST00000367654_DHRS7_chr14_60622870_ENST00000216500_length(amino acids)=1193AA_BP=896
MALAGLCALLACCWGPAAVLATAAGDVDPSKELECKLKSITVSALPFLRENDLSIMHSPSASEPKLLFSVRNDFPGEMVVVDDLENTELP
YFVLEISGNTEDIPLVRWRQQWLENGTLLFHIHHQDGAPSLPGQDPTEEPQHESAEEELRILHISVMGGMIALLLSILCLVMILYTRRRW
CKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQRECMNGGEDFASQVTR
TLDSLQGCNEKSGMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKRINNKARAGSAFLNPEGDSGTEAENDPQLT
FYTDPSRSRRRSRVGSPRSPVNKTTLTLISITSCVIGLVCSSHVNCPLVVKITLHVPEHLIADGSRFILLEGSQLDASDWLNPAQVVLFS
QQNSSGPWAMDLCARRLLDPCEHQCDPETGRREHRAAGECLCYEGYMKDPVHKHLCIRNEWGTNQGPWPYTIFQRGFDLVLGEQPSDKIF
RFTYTLGEGMWLPLSKSFVIPPAELAINPSAKCKTDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSKDNGGCSKNFRCISDRK
LDSTGCVCPSGLSPMKDSSGCYDRHIGVDCSDGFNGGCEQLCLQQMAPFPDDPTLYNILMFCGCIEDYKLGVDGRSCQLITETCPEGSDC
GESRELPMNQTLFGEMFFGYNNHSKEVAAGQVLKGTFRQNNFARGLDQQLPDGLVVATVPLENQCLEEISEPTPDPDFLTGMVNFSEVSG
YPVLQHWKVRSVMYHIKLNQVAISQALSNALHSLDGATSRADFVALLDQFGNHYIQEAIYGFEESCSIWYPNKQVQRRLWLEYEDISKEW
ELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDILV
NNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPG
IIVSNICPGPVQSNIVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQYMPTWAWWITNKMGKKR

--------------------------------------------------------------
>7262_7262_4_ASTN1-DHRS7_ASTN1_chr1_176903288_ENST00000367654_DHRS7_chr14_60622870_ENST00000557185_length(transcript)=3976nt_BP=2907nt
GCTCCGGGAAACAAAGAATCCGGGGCTCTCCAGACATCAGAGCTTAAACCCAGGACTCTGCAAGCGGCATCTCATTCCGGGGTCCAGGGC
TCTCCCGGCTCTCCATCCCCTCCCTAACCTCCCCCGCCTCCCGCGCTCGCTCCCTCGCTCCCTCCCCGCTCGCTTCCTCCCCCACCATCG
CAGCGCTAGGAGGAAGGCGGCCGGGGCTCAAGATGGCTTTAGCCGGGCTCTGCGCCCTGCTCGCCTGCTGCTGGGGGCCGGCGGCGGTGC
TGGCCACGGCCGCCGGCGACGTGGATCCATCCAAGGAGCTGGAGTGCAAGCTCAAAAGCATCACGGTGTCGGCACTGCCCTTCCTGCGCG
AGAACGACCTGAGCATCATGCACAGCCCCTCGGCCTCGGAGCCCAAGCTCCTCTTCTCGGTGCGCAACGACTTCCCGGGAGAAATGGTCG
TGGTGGACGACCTGGAGAACACGGAGCTGCCCTACTTCGTGCTGGAGATCTCAGGGAACACAGAGGATATCCCTTTGGTGCGCTGGAGGC
AGCAGTGGCTGGAGAATGGCACTTTGCTTTTTCACATTCATCACCAAGATGGTGCCCCAAGCCTTCCTGGACAAGACCCCACTGAAGAAC
CCCAACATGAGTCGGCAGAAGAGGAGCTGAGGATCCTCCACATCTCAGTCATGGGTGGCATGATCGCTCTGCTGCTGTCCATCTTGTGCC
TGGTGATGATCCTGTATACTCGCCGGCGCTGGTGCAAACGCCGCCGGGTCCCGCAGCCCCAGAAGAGTGCCAGTGCTGAGGCAGCCAATG
AGATTCACTACATTCCTTCTGTGCTGATCGGCGGGCACGGACGGGAGAGCCTGCGCAATGCCCGCGTGCAGGGCCACAACTCCAGTGGCA
CCCTGAGCATCCGGGAGACACCTATCCTGGACGGCTATGAGTATGACATCACTGATCTGCGCCACCATCTGCAGAGGGAGTGCATGAACG
GAGGGGAGGACTTTGCCAGCCAGGTCACGCGCACCCTCGACTCCCTGCAGGGCTGCAATGAAAAGTCGGGGATGGACCTCACACCAGGAA
GTGACAATGCCAAGCTGTCACTGATGAACAAGTATAAAGATAATATTATAGCCACTAGCCCTGTGGACTCCAACCACCAGCAAGCCACCC
TTCTCTCTCACACCTCCAGCAGCCAGAGAAAGCGGATCAACAACAAAGCAAGAGCTGGTTCCGCCTTCTTGAACCCTGAAGGGGATTCTG
GCACAGAGGCAGAAAACGACCCCCAGCTGACCTTTTACACGGATCCTTCAAGGAGCAGGAGGCGTAGTAGAGTGGGTTCTCCCCGAAGTC
CTGTGAATAAGACCACCTTGACCCTGATCAGCATCACCAGCTGTGTGATTGGCCTCGTGTGCTCCTCTCACGTCAACTGCCCTCTCGTTG
TCAAGATCACCCTGCATGTCCCTGAGCACCTGATTGCTGATGGGAGCCGCTTCATCTTGCTGGAGGGGAGCCAGCTGGATGCCAGTGACT
GGCTGAACCCTGCCCAAGTGGTTCTCTTCTCTCAGCAGAACTCCAGCGGACCCTGGGCCATGGACCTCTGTGCCCGGCGGCTCCTGGACC
CCTGTGAACACCAATGTGACCCCGAAACTGGTAGGCGGGAGCACCGGGCAGCGGGGGAATGCCTCTGCTATGAAGGCTACATGAAGGATC
CAGTACATAAGCACCTTTGCATTCGGAACGAATGGGGGACAAACCAGGGGCCATGGCCTTACACAATATTTCAGCGAGGCTTTGACCTGG
TTTTGGGAGAGCAGCCCTCTGATAAAATATTTAGATTCACCTACACTCTTGGGGAGGGCATGTGGTTGCCCCTCAGCAAGAGCTTTGTGA
TTCCACCAGCCGAACTGGCCATCAATCCATCAGCAAAGTGCAAGACGGACATGACTGTGATGGAGGATGCTGTGGAGGTCAGAGAGGAGC
TGATGACTTCATCCTCCTTCGACAGCCTGGAGGTTCTCTTAGATTCCTTTGGGCCGGTGCGCGACTGCAGCAAAGATAACGGGGGCTGCA
GTAAGAATTTCCGCTGTATTTCAGATCGCAAGCTGGACTCCACTGGTTGCGTGTGCCCATCTGGACTCAGTCCCATGAAGGACAGCTCTG
GCTGCTATGACCGCCACATCGGGGTGGACTGTTCCGACGGCTTCAACGGCGGCTGTGAGCAGCTGTGCCTCCAGCAGATGGCGCCCTTCC
CGGACGACCCCACCTTGTATAACATCCTCATGTTCTGTGGGTGCATCGAGGACTACAAGCTTGGTGTGGATGGACGCTCTTGCCAACTCA
TCACGGAGACCTGTCCAGAGGGAAGTGACTGTGGGGAAAGCAGGGAGCTTCCCATGAACCAGACCCTCTTTGGGGAGATGTTCTTTGGTT
ACAACAACCATTCCAAGGAAGTGGCTGCCGGACAGGTGCTGAAAGGAACATTCAGGCAAAACAACTTTGCTCGTGGTTTAGACCAGCAAC
TGCCAGATGGTCTTGTGGTGGCCACTGTGCCCCTGGAGAATCAATGCCTAGAGGAGATCTCGGAGCCCACCCCTGACCCTGACTTCCTGA
CTGGGATGGTGAACTTCAGTGAAGTGTCTGGGTACCCTGTGCTGCAGCACTGGAAGGTCCGGTCTGTGATGTACCACATCAAACTCAACC
AAGTGGCCATCTCTCAGGCCCTCAGCAATGCTCTCCACTCGCTGGATGGGGCTACATCTCGTGCAGATTTTGTGGCGCTGTTGGACCAGT
TCGGCAACCATTACATCCAGGAAGCTATCTACGGCTTTGAGGAGTCCTGTTCTATCTGGTACCCAAACAAGCAGGTCCAGCGGCGACTCT
GGCTGGAGTATGAAGACATCAGTAAAGAATGGGAGCTGACTGATATGGTGGTGTGGGTGACTGGAGCCTCGAGTGGAATTGGTGAGGAGC
TGGCTTACCAGTTGTCTAAACTAGGAGTTTCTCTTGTGCTGTCAGCCAGAAGAGTGCATGAGCTGGAAAGGGTGAAAAGAAGATGCCTAG
AGAATGGCAATTTAAAAGAAAAAGATATACTTGTTTTGCCCCTTGACCTGACCGACACTGGTTCCCATGAAGCGGCTACCAAAGCTGTTC
TCCAGGAGTTTGGTAGAATCGACATTCTGGTCAACAATGGTGGAATGTCCCAGCGTTCTCTGTGCATGGATACCAGCTTGGATGTCTACA
GAAAGCTAATAGAGCTTAACTACTTAGGGACGGTGTCCTTGACAAAATGTGTTCTGCCTCACATGATCGAGAGGAAGCAAGGAAAGATTG
TTACTGTGAATAGCATCCTGGGTATCATATCTGTACCTCTTTCCATTGGATACTGTGCTAGCAAGCATGCTCTCCGGGGTTTTTTTAATG
GCCTTCGAACAGAACTTGCCACATACCCAGGTATAATAGTTTCTAACATTTGCCCAGGACCTGTGCAATCAAATATTGTGGAGAATTCCC
TAGCTGGAGAAGTCACAAAGACTATAGGCAATAATGGAGACCAGTCCCACAAGATGACAACCAGTCGTTGTGTGCGGCTGATGTTAATCA
GCATGGCCAATGATTTGAAAGAAGTTTGGATCTCAGAACAACCTTTCTTGTTAGTAACATATTTGTGGCAATACATGCCAACCTGGGCCT
GGTGGATAACCAACAAGATGGGGAAGAAAAGGATTGAGAACTTTAAGAGTGGTGTGGATGCAGACTCTTCTTATTTTAAAATCTTTAAGA
CAAAACATGACTGAAAAGAGCACCTGTACTTTTCAAGCCACTGGAGGGAGAAATGGAAAACATGAAAACAGCAATCTTCTTATGCTTCTG
AATAATCAAAGACTAATTTGTGATTTTACTTTTTAATAGATATGACTTTGCTTCCAACATGGAATGAAATAAAAAATAAATAATAAAAGA

>7262_7262_4_ASTN1-DHRS7_ASTN1_chr1_176903288_ENST00000367654_DHRS7_chr14_60622870_ENST00000557185_length(amino acids)=1193AA_BP=896
MALAGLCALLACCWGPAAVLATAAGDVDPSKELECKLKSITVSALPFLRENDLSIMHSPSASEPKLLFSVRNDFPGEMVVVDDLENTELP
YFVLEISGNTEDIPLVRWRQQWLENGTLLFHIHHQDGAPSLPGQDPTEEPQHESAEEELRILHISVMGGMIALLLSILCLVMILYTRRRW
CKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQRECMNGGEDFASQVTR
TLDSLQGCNEKSGMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKRINNKARAGSAFLNPEGDSGTEAENDPQLT
FYTDPSRSRRRSRVGSPRSPVNKTTLTLISITSCVIGLVCSSHVNCPLVVKITLHVPEHLIADGSRFILLEGSQLDASDWLNPAQVVLFS
QQNSSGPWAMDLCARRLLDPCEHQCDPETGRREHRAAGECLCYEGYMKDPVHKHLCIRNEWGTNQGPWPYTIFQRGFDLVLGEQPSDKIF
RFTYTLGEGMWLPLSKSFVIPPAELAINPSAKCKTDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSKDNGGCSKNFRCISDRK
LDSTGCVCPSGLSPMKDSSGCYDRHIGVDCSDGFNGGCEQLCLQQMAPFPDDPTLYNILMFCGCIEDYKLGVDGRSCQLITETCPEGSDC
GESRELPMNQTLFGEMFFGYNNHSKEVAAGQVLKGTFRQNNFARGLDQQLPDGLVVATVPLENQCLEEISEPTPDPDFLTGMVNFSEVSG
YPVLQHWKVRSVMYHIKLNQVAISQALSNALHSLDGATSRADFVALLDQFGNHYIQEAIYGFEESCSIWYPNKQVQRRLWLEYEDISKEW
ELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDILV
NNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPG
IIVSNICPGPVQSNIVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQYMPTWAWWITNKMGKKR

--------------------------------------------------------------
>7262_7262_5_ASTN1-DHRS7_ASTN1_chr1_176903288_ENST00000367657_DHRS7_chr14_60622870_ENST00000216500_length(transcript)=4595nt_BP=2862nt
GGGGCTCTCCAGACATCAGAGCTTAAACCCAGGACTCTGCAAGCGGCATCTCATTCCGGGGTCCAGGGCTCTCCCGGCTCTCCATCCCCT
CCCTAACCTCCCCCGCCTCCCGCGCTCGCTCCCTCGCTCCCTCCCCGCTCGCTTCCTCCCCCACCATCGCAGCGCTAGGAGGAAGGCGGC
CGGGGCTCAAGATGGCTTTAGCCGGGCTCTGCGCCCTGCTCGCCTGCTGCTGGGGGCCGGCGGCGGTGCTGGCCACGGCCGCCGGCGACG
TGGATCCATCCAAGGAGCTGGAGTGCAAGCTCAAAAGCATCACGGTGTCGGCACTGCCCTTCCTGCGCGAGAACGACCTGAGCATCATGC
ACAGCCCCTCGGCCTCGGAGCCCAAGCTCCTCTTCTCGGTGCGCAACGACTTCCCGGGAGAAATGGTCGTGGTGGACGACCTGGAGAACA
CGGAGCTGCCCTACTTCGTGCTGGAGATCTCAGGGAACACAGAGGATATCCCTTTGGTGCGCTGGAGGCAGCAGTGGCTGGAGAATGGCA
CTTTGCTTTTTCACATTCATCACCAAGATGGTGCCCCAAGCCTTCCTGGACAAGACCCCACTGAAGAACCCCAACATGAGTCGGCAGAAG
AGGAGCTGAGGATCCTCCACATCTCAGTCATGGGTGGCATGATCGCTCTGCTGCTGTCCATCTTGTGCCTGGTGATGATCCTGTATACTC
GCCGGCGCTGGTGCAAACGCCGCCGGGTCCCGCAGCCCCAGAAGAGTGCCAGTGCTGAGGCAGCCAATGAGATTCACTACATTCCTTCTG
TGCTGATCGGCGGGCACGGACGGGAGAGCCTGCGCAATGCCCGCGTGCAGGGCCACAACTCCAGTGGCACCCTGAGCATCCGGGAGACAC
CTATCCTGGACGGCTATGAGTATGACATCACTGATCTGCGCCACCATCTGCAGAGGGAGTGCATGAACGGAGGGGAGGACTTTGCCAGCC
AGGTCACGCGCACCCTCGACTCCCTGCAGGGCTGCAATGAAAAGTCGGGGATGGACCTCACACCAGGAAGTGACAATGCCAAGCTGTCAC
TGATGAACAAGTATAAAGATAATATTATAGCCACTAGCCCTGTGGACTCCAACCACCAGCAAGCCACCCTTCTCTCTCACACCTCCAGCA
GCCAGAGAAAGCGGATCAACAACAAAGCAAGAGCTGGTTCCGCCTTCTTGAACCCTGAAGGGGATTCTGGCACAGAGGCAGAAAACGACC
CCCAGCTGACCTTTTACACGGATCCTTCAAGGAGCAGGAGGCGTAGTAGAGTGGGTTCTCCCCGAAGTCCTGTGAATAAGACCACCTTGA
CCCTGATCAGCATCACCAGCTGTGTGATTGGCCTCGTGTGCTCCTCTCACGTCAACTGCCCTCTCGTTGTCAAGATCACCCTGCATGTCC
CTGAGCACCTGATTGCTGATGGGAGCCGCTTCATCTTGCTGGAGGGGAGCCAGCTGGATGCCAGTGACTGGCTGAACCCTGCCCAAGTGG
TTCTCTTCTCTCAGCAGAACTCCAGCGGACCCTGGGCCATGGACCTCTGTGCCCGGCGGCTCCTGGACCCCTGTGAACACCAATGTGACC
CCGAAACTGGGGAATGCCTCTGCTATGAAGGCTACATGAAGGATCCAGTACATAAGCACCTTTGCATTCGGAACGAATGGGGGACAAACC
AGGGGCCATGGCCTTACACAATATTTCAGCGAGGCTTTGACCTGGTTTTGGGAGAGCAGCCCTCTGATAAAATATTTAGATTCACCTACA
CTCTTGGGGAGGGCATGTGGTTGCCCCTCAGCAAGAGCTTTGTGATTCCACCAGCCGAACTGGCCATCAATCCATCAGCAAAGTGCAAGA
CGGACATGACTGTGATGGAGGATGCTGTGGAGGTCAGAGAGGAGCTGATGACTTCATCCTCCTTCGACAGCCTGGAGGTTCTCTTAGATT
CCTTTGGGCCGGTGCGCGACTGCAGCAAAGATAACGGGGGCTGCAGTAAGAATTTCCGCTGTATTTCAGATCGCAAGCTGGACTCCACTG
GTTGCGTGTGCCCATCTGGACTCAGTCCCATGAAGGACAGCTCTGGCTGCTATGACCGCCACATCGGGGTGGACTGTTCCGACGGCTTCA
ACGGCGGCTGTGAGCAGCTGTGCCTCCAGCAGATGGCGCCCTTCCCGGACGACCCCACCTTGTATAACATCCTCATGTTCTGTGGGTGCA
TCGAGGACTACAAGCTTGGTGTGGATGGACGCTCTTGCCAACTCATCACGGAGACCTGTCCAGAGGGAAGTGACTGTGGGGAAAGCAGGG
AGCTTCCCATGAACCAGACCCTCTTTGGGGAGATGTTCTTTGGTTACAACAACCATTCCAAGGAAGTGGCTGCCGGACAGGTGCTGAAAG
GAACATTCAGGCAAAACAACTTTGCTCGTGGTTTAGACCAGCAACTGCCAGATGGTCTTGTGGTGGCCACTGTGCCCCTGGAGAATCAAT
GCCTAGAGGAGATCTCGGAGCCCACCCCTGACCCTGACTTCCTGACTGGGATGGTGAACTTCAGTGAAGTGTCTGGGTACCCTGTGCTGC
AGCACTGGAAGGTCCGGTCTGTGATGTACCACATCAAACTCAACCAAGTGGCCATCTCTCAGGCCCTCAGCAATGCTCTCCACTCGCTGG
ATGGGGCTACATCTCGTGCAGATTTTGTGGCGCTGTTGGACCAGTTCGGCAACCATTACATCCAGGAAGCTATCTACGGCTTTGAGGAGT
CCTGTTCTATCTGGTACCCAAACAAGCAGGTCCAGCGGCGACTCTGGCTGGAGTATGAAGACATCAGTAAAGAATGGGAGCTGACTGATA
TGGTGGTGTGGGTGACTGGAGCCTCGAGTGGAATTGGTGAGGAGCTGGCTTACCAGTTGTCTAAACTAGGAGTTTCTCTTGTGCTGTCAG
CCAGAAGAGTGCATGAGCTGGAAAGGGTGAAAAGAAGATGCCTAGAGAATGGCAATTTAAAAGAAAAAGATATACTTGTTTTGCCCCTTG
ACCTGACCGACACTGGTTCCCATGAAGCGGCTACCAAAGCTGTTCTCCAGGAGTTTGGTAGAATCGACATTCTGGTCAACAATGGTGGAA
TGTCCCAGCGTTCTCTGTGCATGGATACCAGCTTGGATGTCTACAGAAAGCTAATAGAGCTTAACTACTTAGGGACGGTGTCCTTGACAA
AATGTGTTCTGCCTCACATGATCGAGAGGAAGCAAGGAAAGATTGTTACTGTGAATAGCATCCTGGGTATCATATCTGTACCTCTTTCCA
TTGGATACTGTGCTAGCAAGCATGCTCTCCGGGGTTTTTTTAATGGCCTTCGAACAGAACTTGCCACATACCCAGGTATAATAGTTTCTA
ACATTTGCCCAGGACCTGTGCAATCAAATATTGTGGAGAATTCCCTAGCTGGAGAAGTCACAAAGACTATAGGCAATAATGGAGACCAGT
CCCACAAGATGACAACCAGTCGTTGTGTGCGGCTGATGTTAATCAGCATGGCCAATGATTTGAAAGAAGTTTGGATCTCAGAACAACCTT
TCTTGTTAGTAACATATTTGTGGCAATACATGCCAACCTGGGCCTGGTGGATAACCAACAAGATGGGGAAGAAAAGGATTGAGAACTTTA
AGAGTGGTGTGGATGCAGACTCTTCTTATTTTAAAATCTTTAAGACAAAACATGACTGAAAAGAGCACCTGTACTTTTCAAGCCACTGGA
GGGAGAAATGGAAAACATGAAAACAGCAATCTTCTTATGCTTCTGAATAATCAAAGACTAATTTGTGATTTTACTTTTTAATAGATATGA
CTTTGCTTCCAACATGGAATGAAATAAAAAATAAATAATAAAAGATTGCCATGAATCTTGCAAAAAAGGTATTAACTCATACTATATTCT
TGGATAAAATAACCTTTTAAAATACTTTAGCACATATGCTTAAAATCTAAGTTAACAGATTTGTCTTAGTCCATTTGTGCTGCTATAACA
AAATACCACAGATTTGGTAATTTATAAACAACAGAAATCTGTTTTTCCTGGCTCTTGAGGCTGGGAATTCCAAGACCAATGCACCAGCAG
AATTAGTGTCTGGTGAAGGCTGATCTCTGCTTCCAAGATGGCACCTCATTGCTGCATCCTCCACAGTGGAGGAATGTATGTCCTCACATG
GTGGAAGGGACAGAAGGGAAAGAGGAGCAAAATGCTTTCAAAAGAGCATTTAATCTCATTCATTACTCAGTCACCTCTTAAAGGCCACAT
CCTTTAATACTGTTGCTTTGGGGATTAAGTTTCGACATGAATTTTGGAGGGGACAAAAACATCCAAACCATAGCAACATAAATGTATAGA
ATATTTCACACAAAGCAGAGTGCTGGGTAATGACCAGATATAAAGAAGTATTTGAAATGACCTTACCTCCAAGATGCTTATACTCTTAGA
AAAGTTGACAGGTACAGATGGCTGTAATTTGAAGCAGCAGGTAGGATTCATTGCACCTATTATTCATTAAACACCTGTTGTATGTCTTCT

>7262_7262_5_ASTN1-DHRS7_ASTN1_chr1_176903288_ENST00000367657_DHRS7_chr14_60622870_ENST00000216500_length(amino acids)=1185AA_BP=888
MALAGLCALLACCWGPAAVLATAAGDVDPSKELECKLKSITVSALPFLRENDLSIMHSPSASEPKLLFSVRNDFPGEMVVVDDLENTELP
YFVLEISGNTEDIPLVRWRQQWLENGTLLFHIHHQDGAPSLPGQDPTEEPQHESAEEELRILHISVMGGMIALLLSILCLVMILYTRRRW
CKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQRECMNGGEDFASQVTR
TLDSLQGCNEKSGMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKRINNKARAGSAFLNPEGDSGTEAENDPQLT
FYTDPSRSRRRSRVGSPRSPVNKTTLTLISITSCVIGLVCSSHVNCPLVVKITLHVPEHLIADGSRFILLEGSQLDASDWLNPAQVVLFS
QQNSSGPWAMDLCARRLLDPCEHQCDPETGECLCYEGYMKDPVHKHLCIRNEWGTNQGPWPYTIFQRGFDLVLGEQPSDKIFRFTYTLGE
GMWLPLSKSFVIPPAELAINPSAKCKTDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSKDNGGCSKNFRCISDRKLDSTGCVC
PSGLSPMKDSSGCYDRHIGVDCSDGFNGGCEQLCLQQMAPFPDDPTLYNILMFCGCIEDYKLGVDGRSCQLITETCPEGSDCGESRELPM
NQTLFGEMFFGYNNHSKEVAAGQVLKGTFRQNNFARGLDQQLPDGLVVATVPLENQCLEEISEPTPDPDFLTGMVNFSEVSGYPVLQHWK
VRSVMYHIKLNQVAISQALSNALHSLDGATSRADFVALLDQFGNHYIQEAIYGFEESCSIWYPNKQVQRRLWLEYEDISKEWELTDMVVW
VTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQR
SLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICP
GPVQSNIVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQYMPTWAWWITNKMGKKRIENFKSGV

--------------------------------------------------------------
>7262_7262_6_ASTN1-DHRS7_ASTN1_chr1_176903288_ENST00000367657_DHRS7_chr14_60622870_ENST00000557185_length(transcript)=3931nt_BP=2862nt
GGGGCTCTCCAGACATCAGAGCTTAAACCCAGGACTCTGCAAGCGGCATCTCATTCCGGGGTCCAGGGCTCTCCCGGCTCTCCATCCCCT
CCCTAACCTCCCCCGCCTCCCGCGCTCGCTCCCTCGCTCCCTCCCCGCTCGCTTCCTCCCCCACCATCGCAGCGCTAGGAGGAAGGCGGC
CGGGGCTCAAGATGGCTTTAGCCGGGCTCTGCGCCCTGCTCGCCTGCTGCTGGGGGCCGGCGGCGGTGCTGGCCACGGCCGCCGGCGACG
TGGATCCATCCAAGGAGCTGGAGTGCAAGCTCAAAAGCATCACGGTGTCGGCACTGCCCTTCCTGCGCGAGAACGACCTGAGCATCATGC
ACAGCCCCTCGGCCTCGGAGCCCAAGCTCCTCTTCTCGGTGCGCAACGACTTCCCGGGAGAAATGGTCGTGGTGGACGACCTGGAGAACA
CGGAGCTGCCCTACTTCGTGCTGGAGATCTCAGGGAACACAGAGGATATCCCTTTGGTGCGCTGGAGGCAGCAGTGGCTGGAGAATGGCA
CTTTGCTTTTTCACATTCATCACCAAGATGGTGCCCCAAGCCTTCCTGGACAAGACCCCACTGAAGAACCCCAACATGAGTCGGCAGAAG
AGGAGCTGAGGATCCTCCACATCTCAGTCATGGGTGGCATGATCGCTCTGCTGCTGTCCATCTTGTGCCTGGTGATGATCCTGTATACTC
GCCGGCGCTGGTGCAAACGCCGCCGGGTCCCGCAGCCCCAGAAGAGTGCCAGTGCTGAGGCAGCCAATGAGATTCACTACATTCCTTCTG
TGCTGATCGGCGGGCACGGACGGGAGAGCCTGCGCAATGCCCGCGTGCAGGGCCACAACTCCAGTGGCACCCTGAGCATCCGGGAGACAC
CTATCCTGGACGGCTATGAGTATGACATCACTGATCTGCGCCACCATCTGCAGAGGGAGTGCATGAACGGAGGGGAGGACTTTGCCAGCC
AGGTCACGCGCACCCTCGACTCCCTGCAGGGCTGCAATGAAAAGTCGGGGATGGACCTCACACCAGGAAGTGACAATGCCAAGCTGTCAC
TGATGAACAAGTATAAAGATAATATTATAGCCACTAGCCCTGTGGACTCCAACCACCAGCAAGCCACCCTTCTCTCTCACACCTCCAGCA
GCCAGAGAAAGCGGATCAACAACAAAGCAAGAGCTGGTTCCGCCTTCTTGAACCCTGAAGGGGATTCTGGCACAGAGGCAGAAAACGACC
CCCAGCTGACCTTTTACACGGATCCTTCAAGGAGCAGGAGGCGTAGTAGAGTGGGTTCTCCCCGAAGTCCTGTGAATAAGACCACCTTGA
CCCTGATCAGCATCACCAGCTGTGTGATTGGCCTCGTGTGCTCCTCTCACGTCAACTGCCCTCTCGTTGTCAAGATCACCCTGCATGTCC
CTGAGCACCTGATTGCTGATGGGAGCCGCTTCATCTTGCTGGAGGGGAGCCAGCTGGATGCCAGTGACTGGCTGAACCCTGCCCAAGTGG
TTCTCTTCTCTCAGCAGAACTCCAGCGGACCCTGGGCCATGGACCTCTGTGCCCGGCGGCTCCTGGACCCCTGTGAACACCAATGTGACC
CCGAAACTGGGGAATGCCTCTGCTATGAAGGCTACATGAAGGATCCAGTACATAAGCACCTTTGCATTCGGAACGAATGGGGGACAAACC
AGGGGCCATGGCCTTACACAATATTTCAGCGAGGCTTTGACCTGGTTTTGGGAGAGCAGCCCTCTGATAAAATATTTAGATTCACCTACA
CTCTTGGGGAGGGCATGTGGTTGCCCCTCAGCAAGAGCTTTGTGATTCCACCAGCCGAACTGGCCATCAATCCATCAGCAAAGTGCAAGA
CGGACATGACTGTGATGGAGGATGCTGTGGAGGTCAGAGAGGAGCTGATGACTTCATCCTCCTTCGACAGCCTGGAGGTTCTCTTAGATT
CCTTTGGGCCGGTGCGCGACTGCAGCAAAGATAACGGGGGCTGCAGTAAGAATTTCCGCTGTATTTCAGATCGCAAGCTGGACTCCACTG
GTTGCGTGTGCCCATCTGGACTCAGTCCCATGAAGGACAGCTCTGGCTGCTATGACCGCCACATCGGGGTGGACTGTTCCGACGGCTTCA
ACGGCGGCTGTGAGCAGCTGTGCCTCCAGCAGATGGCGCCCTTCCCGGACGACCCCACCTTGTATAACATCCTCATGTTCTGTGGGTGCA
TCGAGGACTACAAGCTTGGTGTGGATGGACGCTCTTGCCAACTCATCACGGAGACCTGTCCAGAGGGAAGTGACTGTGGGGAAAGCAGGG
AGCTTCCCATGAACCAGACCCTCTTTGGGGAGATGTTCTTTGGTTACAACAACCATTCCAAGGAAGTGGCTGCCGGACAGGTGCTGAAAG
GAACATTCAGGCAAAACAACTTTGCTCGTGGTTTAGACCAGCAACTGCCAGATGGTCTTGTGGTGGCCACTGTGCCCCTGGAGAATCAAT
GCCTAGAGGAGATCTCGGAGCCCACCCCTGACCCTGACTTCCTGACTGGGATGGTGAACTTCAGTGAAGTGTCTGGGTACCCTGTGCTGC
AGCACTGGAAGGTCCGGTCTGTGATGTACCACATCAAACTCAACCAAGTGGCCATCTCTCAGGCCCTCAGCAATGCTCTCCACTCGCTGG
ATGGGGCTACATCTCGTGCAGATTTTGTGGCGCTGTTGGACCAGTTCGGCAACCATTACATCCAGGAAGCTATCTACGGCTTTGAGGAGT
CCTGTTCTATCTGGTACCCAAACAAGCAGGTCCAGCGGCGACTCTGGCTGGAGTATGAAGACATCAGTAAAGAATGGGAGCTGACTGATA
TGGTGGTGTGGGTGACTGGAGCCTCGAGTGGAATTGGTGAGGAGCTGGCTTACCAGTTGTCTAAACTAGGAGTTTCTCTTGTGCTGTCAG
CCAGAAGAGTGCATGAGCTGGAAAGGGTGAAAAGAAGATGCCTAGAGAATGGCAATTTAAAAGAAAAAGATATACTTGTTTTGCCCCTTG
ACCTGACCGACACTGGTTCCCATGAAGCGGCTACCAAAGCTGTTCTCCAGGAGTTTGGTAGAATCGACATTCTGGTCAACAATGGTGGAA
TGTCCCAGCGTTCTCTGTGCATGGATACCAGCTTGGATGTCTACAGAAAGCTAATAGAGCTTAACTACTTAGGGACGGTGTCCTTGACAA
AATGTGTTCTGCCTCACATGATCGAGAGGAAGCAAGGAAAGATTGTTACTGTGAATAGCATCCTGGGTATCATATCTGTACCTCTTTCCA
TTGGATACTGTGCTAGCAAGCATGCTCTCCGGGGTTTTTTTAATGGCCTTCGAACAGAACTTGCCACATACCCAGGTATAATAGTTTCTA
ACATTTGCCCAGGACCTGTGCAATCAAATATTGTGGAGAATTCCCTAGCTGGAGAAGTCACAAAGACTATAGGCAATAATGGAGACCAGT
CCCACAAGATGACAACCAGTCGTTGTGTGCGGCTGATGTTAATCAGCATGGCCAATGATTTGAAAGAAGTTTGGATCTCAGAACAACCTT
TCTTGTTAGTAACATATTTGTGGCAATACATGCCAACCTGGGCCTGGTGGATAACCAACAAGATGGGGAAGAAAAGGATTGAGAACTTTA
AGAGTGGTGTGGATGCAGACTCTTCTTATTTTAAAATCTTTAAGACAAAACATGACTGAAAAGAGCACCTGTACTTTTCAAGCCACTGGA
GGGAGAAATGGAAAACATGAAAACAGCAATCTTCTTATGCTTCTGAATAATCAAAGACTAATTTGTGATTTTACTTTTTAATAGATATGA

>7262_7262_6_ASTN1-DHRS7_ASTN1_chr1_176903288_ENST00000367657_DHRS7_chr14_60622870_ENST00000557185_length(amino acids)=1185AA_BP=888
MALAGLCALLACCWGPAAVLATAAGDVDPSKELECKLKSITVSALPFLRENDLSIMHSPSASEPKLLFSVRNDFPGEMVVVDDLENTELP
YFVLEISGNTEDIPLVRWRQQWLENGTLLFHIHHQDGAPSLPGQDPTEEPQHESAEEELRILHISVMGGMIALLLSILCLVMILYTRRRW
CKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQRECMNGGEDFASQVTR
TLDSLQGCNEKSGMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKRINNKARAGSAFLNPEGDSGTEAENDPQLT
FYTDPSRSRRRSRVGSPRSPVNKTTLTLISITSCVIGLVCSSHVNCPLVVKITLHVPEHLIADGSRFILLEGSQLDASDWLNPAQVVLFS
QQNSSGPWAMDLCARRLLDPCEHQCDPETGECLCYEGYMKDPVHKHLCIRNEWGTNQGPWPYTIFQRGFDLVLGEQPSDKIFRFTYTLGE
GMWLPLSKSFVIPPAELAINPSAKCKTDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSKDNGGCSKNFRCISDRKLDSTGCVC
PSGLSPMKDSSGCYDRHIGVDCSDGFNGGCEQLCLQQMAPFPDDPTLYNILMFCGCIEDYKLGVDGRSCQLITETCPEGSDCGESRELPM
NQTLFGEMFFGYNNHSKEVAAGQVLKGTFRQNNFARGLDQQLPDGLVVATVPLENQCLEEISEPTPDPDFLTGMVNFSEVSGYPVLQHWK
VRSVMYHIKLNQVAISQALSNALHSLDGATSRADFVALLDQFGNHYIQEAIYGFEESCSIWYPNKQVQRRLWLEYEDISKEWELTDMVVW
VTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQR
SLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICP
GPVQSNIVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQYMPTWAWWITNKMGKKRIENFKSGV

--------------------------------------------------------------
>7262_7262_7_ASTN1-DHRS7_ASTN1_chr1_176903288_ENST00000424564_DHRS7_chr14_60622870_ENST00000216500_length(transcript)=4411nt_BP=2678nt
GCTCAAGATGGCTTTAGCCGGGCTCTGCGCCCTGCTCGCCTGCTGCTGGGGGCCGGCGGCGGTGCTGGCCACGGCCGCCGGCGACGTGGA
TCCATCCAAGGAGCTGGAGTGCAAGCTCAAAAGCATCACGGTGTCGGCACTGCCCTTCCTGCGCGAGAACGACCTGAGCATCATGCACAG
CCCCTCGGCCTCGGAGCCCAAGCTCCTCTTCTCGGTGCGCAACGACTTCCCGGGAGAAATGGTCGTGGTGGACGACCTGGAGAACACGGA
GCTGCCCTACTTCGTGCTGGAGATCTCAGGGAACACAGAGGATATCCCTTTGGTGCGCTGGAGGCAGCAGTGGCTGGAGAATGGCACTTT
GCTTTTTCACATTCATCACCAAGATGGTGCCCCAAGCCTTCCTGGACAAGACCCCACTGAAGAACCCCAACATGAGTCGGCAGAAGAGGA
GCTGAGGATCCTCCACATCTCAGTCATGGGTGGCATGATCGCTCTGCTGCTGTCCATCTTGTGCCTGGTGATGATCCTGTATACTCGCCG
GCGCTGGTGCAAACGCCGCCGGGTCCCGCAGCCCCAGAAGAGTGCCAGTGCTGAGGCAGCCAATGAGATTCACTACATTCCTTCTGTGCT
GATCGGCGGGCACGGACGGGAGAGCCTGCGCAATGCCCGCGTGCAGGGCCACAACTCCAGTGGCACCCTGAGCATCCGGGAGACACCTAT
CCTGGACGGCTATGAGTATGACATCACTGATCTGCGCCACCATCTGCAGAGGGAGTGCATGAACGGAGGGGAGGACTTTGCCAGCCAGGT
CACGCGCACCCTCGACTCCCTGCAGGGCTGCAATGAAAAGTCGGGGATGGACCTCACACCAGGAAGTGACAATGCCAAGCTGTCACTGAT
GAACAAGTATAAAGATAATATTATAGCCACTAGCCCTGTGGACTCCAACCACCAGCAAGCCACCCTTCTCTCTCACACCTCCAGCAGCCA
GAGAAAGCGGATCAACAACAAAGCAAGAGCTGGTTCCGCCTTCTTGAACCCTGAAGGGGATTCTGGCACAGAGGCAGAAAACGACCCCCA
GCTGACCTTTTACACGGATCCTTCAAGGAGCAGGAGGCGTAGTAGAGTGGGTTCTCCCCGAAGTCCTGTGAATAAGACCACCTTGACCCT
GATCAGCATCACCAGCTGTGTGATTGGCCTCGTGTGCTCCTCTCACGTCAACTGCCCTCTCGTTGTCAAGATCACCCTGCATGTCCCTGA
GCACCTGATTGCTGATGGGAGCCGCTTCATCTTGCTGGAGGGGAGCCAGCTGGATGCCAGTGACTGGCTGAACCCTGCCCAAGTGGTTCT
CTTCTCTCAGCAGAACTCCAGCGGACCCTGGGCCATGGACCTCTGTGCCCGGCGGCTCCTGGACCCCTGTGAACACCAATGTGACCCCGA
AACTGGGGAATGCCTCTGCTATGAAGGCTACATGAAGGATCCAGTACATAAGCACCTTTGCATTCGGAACGAATGGGGGACAAACCAGGG
GCCATGGCCTTACACAATATTTCAGCGAGGCTTTGACCTGGTTTTGGGAGAGCAGCCCTCTGATAAAATATTTAGATTCACCTACACTCT
TGGGGAGGGCATGTGGTTGCCCCTCAGCAAGAGCTTTGTGATTCCACCAGCCGAACTGGCCATCAATCCATCAGCAAAGTGCAAGACGGA
CATGACTGTGATGGAGGATGCTGTGGAGGTCAGAGAGGAGCTGATGACTTCATCCTCCTTCGACAGCCTGGAGGTTCTCTTAGATTCCTT
TGGGCCGGTGCGCGACTGCAGCAAAGATAACGGGGGCTGCAGTAAGAATTTCCGCTGTATTTCAGATCGCAAGCTGGACTCCACTGGTTG
CGTGTGCCCATCTGGACTCAGTCCCATGAAGGACAGCTCTGGCTGCTATGACCGCCACATCGGGGTGGACTGTTCCGACGGCTTCAACGG
CGGCTGTGAGCAGCTGTGCCTCCAGCAGATGGCGCCCTTCCCGGACGACCCCACCTTGTATAACATCCTCATGTTCTGTGGGTGCATCGA
GGACTACAAGCTTGGTGTGGATGGACGCTCTTGCCAACTCATCACGGAGACCTGTCCAGAGGGAAGTGACTGTGGGGAAAGCAGGGAGCT
TCCCATGAACCAGACCCTCTTTGGGGAGATGTTCTTTGGTTACAACAACCATTCCAAGGAAGTGGCTGCCGGACAGGTGCTGAAAGGAAC
ATTCAGGCAAAACAACTTTGCTCGTGGTTTAGACCAGCAACTGCCAGATGGTCTTGTGGTGGCCACTGTGCCCCTGGAGAATCAATGCCT
AGAGGAGATCTCGGAGCCCACCCCTGACCCTGACTTCCTGACTGGGATGGTGAACTTCAGTGAAGTGTCTGGGTACCCTGTGCTGCAGCA
CTGGAAGGTCCGGTCTGTGATGTACCACATCAAACTCAACCAAGTGGCCATCTCTCAGGCCCTCAGCAATGCTCTCCACTCGCTGGATGG
GGCTACATCTCGTGCAGATTTTGTGGCGCTGTTGGACCAGTTCGGCAACCATTACATCCAGGAAGCTATCTACGGCTTTGAGGAGTCCTG
TTCTATCTGGTACCCAAACAAGCAGGTCCAGCGGCGACTCTGGCTGGAGTATGAAGACATCAGTAAAGAATGGGAGCTGACTGATATGGT
GGTGTGGGTGACTGGAGCCTCGAGTGGAATTGGTGAGGAGCTGGCTTACCAGTTGTCTAAACTAGGAGTTTCTCTTGTGCTGTCAGCCAG
AAGAGTGCATGAGCTGGAAAGGGTGAAAAGAAGATGCCTAGAGAATGGCAATTTAAAAGAAAAAGATATACTTGTTTTGCCCCTTGACCT
GACCGACACTGGTTCCCATGAAGCGGCTACCAAAGCTGTTCTCCAGGAGTTTGGTAGAATCGACATTCTGGTCAACAATGGTGGAATGTC
CCAGCGTTCTCTGTGCATGGATACCAGCTTGGATGTCTACAGAAAGCTAATAGAGCTTAACTACTTAGGGACGGTGTCCTTGACAAAATG
TGTTCTGCCTCACATGATCGAGAGGAAGCAAGGAAAGATTGTTACTGTGAATAGCATCCTGGGTATCATATCTGTACCTCTTTCCATTGG
ATACTGTGCTAGCAAGCATGCTCTCCGGGGTTTTTTTAATGGCCTTCGAACAGAACTTGCCACATACCCAGGTATAATAGTTTCTAACAT
TTGCCCAGGACCTGTGCAATCAAATATTGTGGAGAATTCCCTAGCTGGAGAAGTCACAAAGACTATAGGCAATAATGGAGACCAGTCCCA
CAAGATGACAACCAGTCGTTGTGTGCGGCTGATGTTAATCAGCATGGCCAATGATTTGAAAGAAGTTTGGATCTCAGAACAACCTTTCTT
GTTAGTAACATATTTGTGGCAATACATGCCAACCTGGGCCTGGTGGATAACCAACAAGATGGGGAAGAAAAGGATTGAGAACTTTAAGAG
TGGTGTGGATGCAGACTCTTCTTATTTTAAAATCTTTAAGACAAAACATGACTGAAAAGAGCACCTGTACTTTTCAAGCCACTGGAGGGA
GAAATGGAAAACATGAAAACAGCAATCTTCTTATGCTTCTGAATAATCAAAGACTAATTTGTGATTTTACTTTTTAATAGATATGACTTT
GCTTCCAACATGGAATGAAATAAAAAATAAATAATAAAAGATTGCCATGAATCTTGCAAAAAAGGTATTAACTCATACTATATTCTTGGA
TAAAATAACCTTTTAAAATACTTTAGCACATATGCTTAAAATCTAAGTTAACAGATTTGTCTTAGTCCATTTGTGCTGCTATAACAAAAT
ACCACAGATTTGGTAATTTATAAACAACAGAAATCTGTTTTTCCTGGCTCTTGAGGCTGGGAATTCCAAGACCAATGCACCAGCAGAATT
AGTGTCTGGTGAAGGCTGATCTCTGCTTCCAAGATGGCACCTCATTGCTGCATCCTCCACAGTGGAGGAATGTATGTCCTCACATGGTGG
AAGGGACAGAAGGGAAAGAGGAGCAAAATGCTTTCAAAAGAGCATTTAATCTCATTCATTACTCAGTCACCTCTTAAAGGCCACATCCTT
TAATACTGTTGCTTTGGGGATTAAGTTTCGACATGAATTTTGGAGGGGACAAAAACATCCAAACCATAGCAACATAAATGTATAGAATAT
TTCACACAAAGCAGAGTGCTGGGTAATGACCAGATATAAAGAAGTATTTGAAATGACCTTACCTCCAAGATGCTTATACTCTTAGAAAAG
TTGACAGGTACAGATGGCTGTAATTTGAAGCAGCAGGTAGGATTCATTGCACCTATTATTCATTAAACACCTGTTGTATGTCTTCTACTG

>7262_7262_7_ASTN1-DHRS7_ASTN1_chr1_176903288_ENST00000424564_DHRS7_chr14_60622870_ENST00000216500_length(amino acids)=1185AA_BP=888
MALAGLCALLACCWGPAAVLATAAGDVDPSKELECKLKSITVSALPFLRENDLSIMHSPSASEPKLLFSVRNDFPGEMVVVDDLENTELP
YFVLEISGNTEDIPLVRWRQQWLENGTLLFHIHHQDGAPSLPGQDPTEEPQHESAEEELRILHISVMGGMIALLLSILCLVMILYTRRRW
CKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQRECMNGGEDFASQVTR
TLDSLQGCNEKSGMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKRINNKARAGSAFLNPEGDSGTEAENDPQLT
FYTDPSRSRRRSRVGSPRSPVNKTTLTLISITSCVIGLVCSSHVNCPLVVKITLHVPEHLIADGSRFILLEGSQLDASDWLNPAQVVLFS
QQNSSGPWAMDLCARRLLDPCEHQCDPETGECLCYEGYMKDPVHKHLCIRNEWGTNQGPWPYTIFQRGFDLVLGEQPSDKIFRFTYTLGE
GMWLPLSKSFVIPPAELAINPSAKCKTDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSKDNGGCSKNFRCISDRKLDSTGCVC
PSGLSPMKDSSGCYDRHIGVDCSDGFNGGCEQLCLQQMAPFPDDPTLYNILMFCGCIEDYKLGVDGRSCQLITETCPEGSDCGESRELPM
NQTLFGEMFFGYNNHSKEVAAGQVLKGTFRQNNFARGLDQQLPDGLVVATVPLENQCLEEISEPTPDPDFLTGMVNFSEVSGYPVLQHWK
VRSVMYHIKLNQVAISQALSNALHSLDGATSRADFVALLDQFGNHYIQEAIYGFEESCSIWYPNKQVQRRLWLEYEDISKEWELTDMVVW
VTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQR
SLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICP
GPVQSNIVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQYMPTWAWWITNKMGKKRIENFKSGV

--------------------------------------------------------------
>7262_7262_8_ASTN1-DHRS7_ASTN1_chr1_176903288_ENST00000424564_DHRS7_chr14_60622870_ENST00000557185_length(transcript)=3747nt_BP=2678nt
GCTCAAGATGGCTTTAGCCGGGCTCTGCGCCCTGCTCGCCTGCTGCTGGGGGCCGGCGGCGGTGCTGGCCACGGCCGCCGGCGACGTGGA
TCCATCCAAGGAGCTGGAGTGCAAGCTCAAAAGCATCACGGTGTCGGCACTGCCCTTCCTGCGCGAGAACGACCTGAGCATCATGCACAG
CCCCTCGGCCTCGGAGCCCAAGCTCCTCTTCTCGGTGCGCAACGACTTCCCGGGAGAAATGGTCGTGGTGGACGACCTGGAGAACACGGA
GCTGCCCTACTTCGTGCTGGAGATCTCAGGGAACACAGAGGATATCCCTTTGGTGCGCTGGAGGCAGCAGTGGCTGGAGAATGGCACTTT
GCTTTTTCACATTCATCACCAAGATGGTGCCCCAAGCCTTCCTGGACAAGACCCCACTGAAGAACCCCAACATGAGTCGGCAGAAGAGGA
GCTGAGGATCCTCCACATCTCAGTCATGGGTGGCATGATCGCTCTGCTGCTGTCCATCTTGTGCCTGGTGATGATCCTGTATACTCGCCG
GCGCTGGTGCAAACGCCGCCGGGTCCCGCAGCCCCAGAAGAGTGCCAGTGCTGAGGCAGCCAATGAGATTCACTACATTCCTTCTGTGCT
GATCGGCGGGCACGGACGGGAGAGCCTGCGCAATGCCCGCGTGCAGGGCCACAACTCCAGTGGCACCCTGAGCATCCGGGAGACACCTAT
CCTGGACGGCTATGAGTATGACATCACTGATCTGCGCCACCATCTGCAGAGGGAGTGCATGAACGGAGGGGAGGACTTTGCCAGCCAGGT
CACGCGCACCCTCGACTCCCTGCAGGGCTGCAATGAAAAGTCGGGGATGGACCTCACACCAGGAAGTGACAATGCCAAGCTGTCACTGAT
GAACAAGTATAAAGATAATATTATAGCCACTAGCCCTGTGGACTCCAACCACCAGCAAGCCACCCTTCTCTCTCACACCTCCAGCAGCCA
GAGAAAGCGGATCAACAACAAAGCAAGAGCTGGTTCCGCCTTCTTGAACCCTGAAGGGGATTCTGGCACAGAGGCAGAAAACGACCCCCA
GCTGACCTTTTACACGGATCCTTCAAGGAGCAGGAGGCGTAGTAGAGTGGGTTCTCCCCGAAGTCCTGTGAATAAGACCACCTTGACCCT
GATCAGCATCACCAGCTGTGTGATTGGCCTCGTGTGCTCCTCTCACGTCAACTGCCCTCTCGTTGTCAAGATCACCCTGCATGTCCCTGA
GCACCTGATTGCTGATGGGAGCCGCTTCATCTTGCTGGAGGGGAGCCAGCTGGATGCCAGTGACTGGCTGAACCCTGCCCAAGTGGTTCT
CTTCTCTCAGCAGAACTCCAGCGGACCCTGGGCCATGGACCTCTGTGCCCGGCGGCTCCTGGACCCCTGTGAACACCAATGTGACCCCGA
AACTGGGGAATGCCTCTGCTATGAAGGCTACATGAAGGATCCAGTACATAAGCACCTTTGCATTCGGAACGAATGGGGGACAAACCAGGG
GCCATGGCCTTACACAATATTTCAGCGAGGCTTTGACCTGGTTTTGGGAGAGCAGCCCTCTGATAAAATATTTAGATTCACCTACACTCT
TGGGGAGGGCATGTGGTTGCCCCTCAGCAAGAGCTTTGTGATTCCACCAGCCGAACTGGCCATCAATCCATCAGCAAAGTGCAAGACGGA
CATGACTGTGATGGAGGATGCTGTGGAGGTCAGAGAGGAGCTGATGACTTCATCCTCCTTCGACAGCCTGGAGGTTCTCTTAGATTCCTT
TGGGCCGGTGCGCGACTGCAGCAAAGATAACGGGGGCTGCAGTAAGAATTTCCGCTGTATTTCAGATCGCAAGCTGGACTCCACTGGTTG
CGTGTGCCCATCTGGACTCAGTCCCATGAAGGACAGCTCTGGCTGCTATGACCGCCACATCGGGGTGGACTGTTCCGACGGCTTCAACGG
CGGCTGTGAGCAGCTGTGCCTCCAGCAGATGGCGCCCTTCCCGGACGACCCCACCTTGTATAACATCCTCATGTTCTGTGGGTGCATCGA
GGACTACAAGCTTGGTGTGGATGGACGCTCTTGCCAACTCATCACGGAGACCTGTCCAGAGGGAAGTGACTGTGGGGAAAGCAGGGAGCT
TCCCATGAACCAGACCCTCTTTGGGGAGATGTTCTTTGGTTACAACAACCATTCCAAGGAAGTGGCTGCCGGACAGGTGCTGAAAGGAAC
ATTCAGGCAAAACAACTTTGCTCGTGGTTTAGACCAGCAACTGCCAGATGGTCTTGTGGTGGCCACTGTGCCCCTGGAGAATCAATGCCT
AGAGGAGATCTCGGAGCCCACCCCTGACCCTGACTTCCTGACTGGGATGGTGAACTTCAGTGAAGTGTCTGGGTACCCTGTGCTGCAGCA
CTGGAAGGTCCGGTCTGTGATGTACCACATCAAACTCAACCAAGTGGCCATCTCTCAGGCCCTCAGCAATGCTCTCCACTCGCTGGATGG
GGCTACATCTCGTGCAGATTTTGTGGCGCTGTTGGACCAGTTCGGCAACCATTACATCCAGGAAGCTATCTACGGCTTTGAGGAGTCCTG
TTCTATCTGGTACCCAAACAAGCAGGTCCAGCGGCGACTCTGGCTGGAGTATGAAGACATCAGTAAAGAATGGGAGCTGACTGATATGGT
GGTGTGGGTGACTGGAGCCTCGAGTGGAATTGGTGAGGAGCTGGCTTACCAGTTGTCTAAACTAGGAGTTTCTCTTGTGCTGTCAGCCAG
AAGAGTGCATGAGCTGGAAAGGGTGAAAAGAAGATGCCTAGAGAATGGCAATTTAAAAGAAAAAGATATACTTGTTTTGCCCCTTGACCT
GACCGACACTGGTTCCCATGAAGCGGCTACCAAAGCTGTTCTCCAGGAGTTTGGTAGAATCGACATTCTGGTCAACAATGGTGGAATGTC
CCAGCGTTCTCTGTGCATGGATACCAGCTTGGATGTCTACAGAAAGCTAATAGAGCTTAACTACTTAGGGACGGTGTCCTTGACAAAATG
TGTTCTGCCTCACATGATCGAGAGGAAGCAAGGAAAGATTGTTACTGTGAATAGCATCCTGGGTATCATATCTGTACCTCTTTCCATTGG
ATACTGTGCTAGCAAGCATGCTCTCCGGGGTTTTTTTAATGGCCTTCGAACAGAACTTGCCACATACCCAGGTATAATAGTTTCTAACAT
TTGCCCAGGACCTGTGCAATCAAATATTGTGGAGAATTCCCTAGCTGGAGAAGTCACAAAGACTATAGGCAATAATGGAGACCAGTCCCA
CAAGATGACAACCAGTCGTTGTGTGCGGCTGATGTTAATCAGCATGGCCAATGATTTGAAAGAAGTTTGGATCTCAGAACAACCTTTCTT
GTTAGTAACATATTTGTGGCAATACATGCCAACCTGGGCCTGGTGGATAACCAACAAGATGGGGAAGAAAAGGATTGAGAACTTTAAGAG
TGGTGTGGATGCAGACTCTTCTTATTTTAAAATCTTTAAGACAAAACATGACTGAAAAGAGCACCTGTACTTTTCAAGCCACTGGAGGGA
GAAATGGAAAACATGAAAACAGCAATCTTCTTATGCTTCTGAATAATCAAAGACTAATTTGTGATTTTACTTTTTAATAGATATGACTTT

>7262_7262_8_ASTN1-DHRS7_ASTN1_chr1_176903288_ENST00000424564_DHRS7_chr14_60622870_ENST00000557185_length(amino acids)=1185AA_BP=888
MALAGLCALLACCWGPAAVLATAAGDVDPSKELECKLKSITVSALPFLRENDLSIMHSPSASEPKLLFSVRNDFPGEMVVVDDLENTELP
YFVLEISGNTEDIPLVRWRQQWLENGTLLFHIHHQDGAPSLPGQDPTEEPQHESAEEELRILHISVMGGMIALLLSILCLVMILYTRRRW
CKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQRECMNGGEDFASQVTR
TLDSLQGCNEKSGMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKRINNKARAGSAFLNPEGDSGTEAENDPQLT
FYTDPSRSRRRSRVGSPRSPVNKTTLTLISITSCVIGLVCSSHVNCPLVVKITLHVPEHLIADGSRFILLEGSQLDASDWLNPAQVVLFS
QQNSSGPWAMDLCARRLLDPCEHQCDPETGECLCYEGYMKDPVHKHLCIRNEWGTNQGPWPYTIFQRGFDLVLGEQPSDKIFRFTYTLGE
GMWLPLSKSFVIPPAELAINPSAKCKTDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSKDNGGCSKNFRCISDRKLDSTGCVC
PSGLSPMKDSSGCYDRHIGVDCSDGFNGGCEQLCLQQMAPFPDDPTLYNILMFCGCIEDYKLGVDGRSCQLITETCPEGSDCGESRELPM
NQTLFGEMFFGYNNHSKEVAAGQVLKGTFRQNNFARGLDQQLPDGLVVATVPLENQCLEEISEPTPDPDFLTGMVNFSEVSGYPVLQHWK
VRSVMYHIKLNQVAISQALSNALHSLDGATSRADFVALLDQFGNHYIQEAIYGFEESCSIWYPNKQVQRRLWLEYEDISKEWELTDMVVW
VTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQR
SLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICP
GPVQSNIVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQYMPTWAWWITNKMGKKRIENFKSGV

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Fusion Gene PPI Analysis for ASTN1-DHRS7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASTN1-DHRS7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASTN1-DHRS7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASTN1C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneASTN1C0014544Epilepsy1GENOMICS_ENGLAND
HgeneASTN1C0740858Substance abuse problem1PSYGENET
HgeneASTN1C2748861Cortical malformations1GENOMICS_ENGLAND
HgeneASTN1C3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneC0015695Fatty Liver1CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC2711227Steatohepatitis1CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human