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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ATF1-HP1BP3 (FusionGDB2 ID:HG466TG50809) |
Fusion Gene Summary for ATF1-HP1BP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATF1-HP1BP3 | Fusion gene ID: hg466tg50809 | Hgene | Tgene | Gene symbol | ATF1 | HP1BP3 | Gene ID | 466 | 50809 |
| Gene name | activating transcription factor 1 | heterochromatin protein 1 binding protein 3 | |
| Synonyms | EWS-ATF1|FUS/ATF-1|TREB36 | HP1-BP74|HP1BP74 | |
| Cytomap | ('ATF1')('HP1BP3') 12q13.12 | 1p36.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclic AMP-dependent transcription factor ATF-1cAMP-dependent transcription factor ATF-1 | heterochromatin protein 1-binding protein 3 | |
| Modification date | 20200315 | 20200313 | |
| UniProtAcc | P18846 | Q5SSJ5 | |
| Ensembl transtripts involved in fusion gene | ENST00000262053, ENST00000539132, | ||
| Fusion gene scores | * DoF score | 8 X 7 X 6=336 | 22 X 14 X 10=3080 |
| # samples | 7 | 24 | |
| ** MAII score | log2(7/336*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(24/3080*10)=-3.68182403997374 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ATF1 [Title/Abstract] AND HP1BP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ATF1(51208222)-HP1BP3(21100103), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ATF1-HP1BP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATF1-HP1BP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATF1-HP1BP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ATF1-HP1BP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATF1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 1655749 |
| Tgene | HP1BP3 | GO:0071456 | cellular response to hypoxia | 25100860 |
| Fusion gene breakpoints across ATF1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across HP1BP3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A2-A0T5-01A | ATF1 | chr12 | 51208222 | + | HP1BP3 | chr1 | 21100103 | - |
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Fusion Gene ORF analysis for ATF1-HP1BP3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000262053 | ENST00000375003 | ATF1 | chr12 | 51208222 | + | HP1BP3 | chr1 | 21100103 | - |
| 5CDS-5UTR | ENST00000539132 | ENST00000375003 | ATF1 | chr12 | 51208222 | + | HP1BP3 | chr1 | 21100103 | - |
| 5CDS-intron | ENST00000262053 | ENST00000375000 | ATF1 | chr12 | 51208222 | + | HP1BP3 | chr1 | 21100103 | - |
| 5CDS-intron | ENST00000262053 | ENST00000487117 | ATF1 | chr12 | 51208222 | + | HP1BP3 | chr1 | 21100103 | - |
| 5CDS-intron | ENST00000539132 | ENST00000375000 | ATF1 | chr12 | 51208222 | + | HP1BP3 | chr1 | 21100103 | - |
| 5CDS-intron | ENST00000539132 | ENST00000487117 | ATF1 | chr12 | 51208222 | + | HP1BP3 | chr1 | 21100103 | - |
| In-frame | ENST00000262053 | ENST00000312239 | ATF1 | chr12 | 51208222 | + | HP1BP3 | chr1 | 21100103 | - |
| In-frame | ENST00000539132 | ENST00000312239 | ATF1 | chr12 | 51208222 | + | HP1BP3 | chr1 | 21100103 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000262053 | ATF1 | chr12 | 51208222 | + | ENST00000312239 | HP1BP3 | chr1 | 21100103 | - | 4141 | 693 | 16 | 2004 | 662 |
| ENST00000539132 | ATF1 | chr12 | 51208222 | + | ENST00000312239 | HP1BP3 | chr1 | 21100103 | - | 4042 | 594 | 280 | 1905 | 541 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000262053 | ENST00000312239 | ATF1 | chr12 | 51208222 | + | HP1BP3 | chr1 | 21100103 | - | 0.00037719 | 0.9996228 |
| ENST00000539132 | ENST00000312239 | ATF1 | chr12 | 51208222 | + | HP1BP3 | chr1 | 21100103 | - | 0.000502137 | 0.9994979 |
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Fusion Genomic Features for ATF1-HP1BP3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ATF1-HP1BP3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:51208222/chr1:21100103) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATF1 | HP1BP3 |
| FUNCTION: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}. | FUNCTION: Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ATF1 | chr12:51208222 | chr1:21100103 | ENST00000262053 | + | 6 | 7 | 31_90 | 223 | 272.0 | Domain | KID |
| Tgene | HP1BP3 | chr12:51208222 | chr1:21100103 | ENST00000312239 | 3 | 13 | 454_553 | 116 | 554.0 | Compositional bias | Note=Lys-rich | |
| Tgene | HP1BP3 | chr12:51208222 | chr1:21100103 | ENST00000375000 | 0 | 5 | 454_553 | 0 | 134.0 | Compositional bias | Note=Lys-rich | |
| Tgene | HP1BP3 | chr12:51208222 | chr1:21100103 | ENST00000375003 | 0 | 9 | 454_553 | 0 | 402.0 | Compositional bias | Note=Lys-rich | |
| Tgene | HP1BP3 | chr12:51208222 | chr1:21100103 | ENST00000312239 | 3 | 13 | 157_232 | 116 | 554.0 | Domain | H15 1 | |
| Tgene | HP1BP3 | chr12:51208222 | chr1:21100103 | ENST00000312239 | 3 | 13 | 255_330 | 116 | 554.0 | Domain | H15 2 | |
| Tgene | HP1BP3 | chr12:51208222 | chr1:21100103 | ENST00000312239 | 3 | 13 | 337_413 | 116 | 554.0 | Domain | H15 3 | |
| Tgene | HP1BP3 | chr12:51208222 | chr1:21100103 | ENST00000375000 | 0 | 5 | 157_232 | 0 | 134.0 | Domain | H15 1 | |
| Tgene | HP1BP3 | chr12:51208222 | chr1:21100103 | ENST00000375000 | 0 | 5 | 255_330 | 0 | 134.0 | Domain | H15 2 | |
| Tgene | HP1BP3 | chr12:51208222 | chr1:21100103 | ENST00000375000 | 0 | 5 | 337_413 | 0 | 134.0 | Domain | H15 3 | |
| Tgene | HP1BP3 | chr12:51208222 | chr1:21100103 | ENST00000375003 | 0 | 9 | 157_232 | 0 | 402.0 | Domain | H15 1 | |
| Tgene | HP1BP3 | chr12:51208222 | chr1:21100103 | ENST00000375003 | 0 | 9 | 255_330 | 0 | 402.0 | Domain | H15 2 | |
| Tgene | HP1BP3 | chr12:51208222 | chr1:21100103 | ENST00000375003 | 0 | 9 | 337_413 | 0 | 402.0 | Domain | H15 3 | |
| Tgene | HP1BP3 | chr12:51208222 | chr1:21100103 | ENST00000312239 | 3 | 13 | 255_259 | 116 | 554.0 | Motif | PxVxL motif | |
| Tgene | HP1BP3 | chr12:51208222 | chr1:21100103 | ENST00000375000 | 0 | 5 | 255_259 | 0 | 134.0 | Motif | PxVxL motif | |
| Tgene | HP1BP3 | chr12:51208222 | chr1:21100103 | ENST00000375003 | 0 | 9 | 255_259 | 0 | 402.0 | Motif | PxVxL motif |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ATF1 | chr12:51208222 | chr1:21100103 | ENST00000262053 | + | 6 | 7 | 213_271 | 223 | 272.0 | Domain | bZIP |
| Hgene | ATF1 | chr12:51208222 | chr1:21100103 | ENST00000262053 | + | 6 | 7 | 215_239 | 223 | 272.0 | Region | Basic motif |
| Hgene | ATF1 | chr12:51208222 | chr1:21100103 | ENST00000262053 | + | 6 | 7 | 241_262 | 223 | 272.0 | Region | Leucine-zipper |
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Fusion Gene Sequence for ATF1-HP1BP3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >7403_7403_1_ATF1-HP1BP3_ATF1_chr12_51208222_ENST00000262053_HP1BP3_chr1_21100103_ENST00000312239_length(transcript)=4141nt_BP=693nt GAGGCGGCAGCCACAGTTGATTATGGAAGATTCCCACAAGAGTACCACGTCAGAGACAGCACCTCAACCTGGTTCAGCAGTTCAGGGAGC TCACATTTCTCATATTGCTCAACAGGTATCATCTTTATCAGAAAGTGAGGAGTCCCAGGACTCATCCGACAGCATAGGCTCCTCACAGAA AGCCCACGGGATCCTAGCACGGCGCCCATCTTACAGAAAAATTTTGAAAGACTTATCTTCTGAAGATACACGGGGCAGAAAAGGAGACGG AGAAAATTCTGGAGTTTCTGCTGCTGTCACTTCTATGTCTGTTCCAACTCCCATCTATCAGACTAGCAGCGGACAGTACATTGCCATTGC CCCAAATGGAGCCTTACAGTTGGCAAGTCCAGGCACAGATGGAGTACAGGGACTTCAGACATTAACCATGACAAATTCAGGCAGTACTCA GCAAGGTACAACTATTCTTCAGTATGCACAGACCTCTGATGGACAGCAGATACTTGTGCCCAGCAATCAGGTGGTCGTACAAACTGCATC AGGAGATATGCAAACATATCAGATCCGAACTACACCTTCAGCTACTTCTCTGCCACAAACTGTGGTGATGACATCTCCTGTGACTCTCAC CTCTCAGACAACTAAGACAGATGACCCCCAATTGAAAAGAGAAATAAGGTTAATGAAAAACAGTGAGAAAGATCAGTCTAAAGAAAAGGA GAAGAAAGTGAAAAAAACAATTCCTTCCTGGGCTACCCTTTCTGCCAGCCAGCTAGCCAGGGCCCAGAAACAAACACCGATGGCTTCTTC CCCACGTCCCAAGATGGATGCAATCTTAACTGAGGCCATTAAGGCATGCTTCCAGAAGAGTGGTGCATCAGTGGTTGCTATTCGAAAATA CATCATCCATAAGTATCCTTCTCTGGAGCTGGAGAGAAGGGGTTATCTCCTTAAACAAGCACTGAAAAGAGAATTAAATAGAGGAGTCAT CAAACAGGTTAAAGGAAAAGGTGCTTCTGGAAGTTTTGTTGTGGTTCAGAAATCAAGAAAAACACCTCAGAAATCCAGAAACAGAAAGAA TAGGAGCTCTGCAGTGGATCCAGAACCACAAGTAAAATTGGAGGATGTCCTCCCACTGGCCTTTACTCGCCTTTGTGAACCTAAAGAAGC TTCCTACAGTCTCATCAGGAAATATGTGTCTCAGTATTATCCTAAGCTTAGAGTGGACATCAGGCCTCAGCTGTTGAAGAACGCTCTGCA GAGAGCAGTAGAGAGGGGCCAGTTAGAACAGATAACTGGCAAAGGTGCTTCGGGGACATTCCAGCTGAAGAAATCAGGGGAGAAACCCCT GCTTGGTGGAAGCCTGATGGAATATGCAATCTTGTCTGCCATTGCTGCCATGAATGAGCCGAAGACCTGCTCTACCACTGCTCTGAAGAA GTATGTCCTAGAGAATCACCCAGGAACCAATTCTAACTATCAAATGCATTTGCTGAAAAAAACCCTGCAGAAATGCGAAAAGAATGGGTG GATGGAACAGATCTCTGGGAAAGGGTTCAGTGGCACCTTCCAGCTCTGTTTTCCCTATTATCCCAGCCCAGGAGTTCTGTTTCCGAAGAA AGAGCCAGATGATTCTAGAGATGAGGATGAAGATGAAGATGAGTCATCAGAAGAAGACTCTGAGGATGAAGAGCCGCCACCTAAGAGAAG GTTGCAGAAGAAAACCCCAGCCAAGTCCCCAGGGAAGGCCGCATCTGTGAAGCAGAGAGGGTCCAAACCTGCACCTAAAGTCTCAGCTGC CCAGCGGGGGAAAGCTAGGCCCTTGCCTAAGAAAGCACCTCCTAAGGCCAAAACGCCTGCCAAGAAGACCAGACCCTCATCCACAGTCAT CAAGAAACCTAGTGGTGGCTCCTCAAAGAAGCCTGCAACCAGTGCAAGAAAGGAAGTAAAATTGCCGGGCAAGGGCAAATCCACCATGAA GAAGTCTTTCAGAGTGAAAAAGTAAATTTTATAGGAAAAAAGGGTATCATGATGAAATTCAAAATCTTATTTTCTAAGGTCAGTGTGCAT TTGTTTAGTTTTGATGCTTTTCAAATTACATTATTTTCCTCCCCTATGAACATTGTGGGGAGGGACTCTAAATAAACCAGTTTAGGCATT TGCTAGCTTTAGGTGCTTTTATTGGTGCCTGCCCTTTTCCTTGTTCATTTTAATTTCTGCAATAATCCTGGACTTTCCTAAACTATGTAA TGTATACTTGTCCTTTTTCTCTGCCTCCCCCAACCCCCTGTTGTTTTTATGGTCAGCTTTGCCTTTTTTTTTTCTTCCAATTTTATCTAA ACAGTTGCAGAGATTTTTATATTTGTAGAAAGCATCAAGAACGGTATGCCAGTCAGGTCCTGGAAGTAAAATGGAGGCACAATATAGCAC TGACTGAGTTGTAAAGCCTCCTGCCTGGAGACTTCAGTTATAGCTGTAATAATTAATCTTATTTATAAAAGCCACTCCACTAACCTTTTC TCTCCAACTGTAAACACAGAGACAGCTTTGGGAATAAGCCAAAAACAGGGTGATCTCATTAGATTTTGAAGATATATGACTCCTTTGGGC TACATTTCATATTGATCAATTTCTAGGTATTTTTCACTGGCCCAAAGTATTGCATTCCCTTAACAGCAAGCACAAGTTCTCTATATCACT TGTTTTTTGTTGTTGTTGTTGTTGTCGTCGTTGTTTTGAGACGGAGTCTTGCTCAGGTGCCCCGGAGTGCAGTGGTGCAATCTCAGCTCA CTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCTTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTACCACCACGCCTGGCA ATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCGTGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTCGG CCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCACTGTGCCTGGCCTATCCCACTTGGTTTTTGACTGAAGGGGAAGTGTAGAAATATAT TGATTTGTGATTTCTGGTGTCACCTGTGTTACCAAAAATCAAAACAAATCTTTTTTATTTTTTATTATTATTATTATTTTTGAGACAGAG TCTCGCTCTGTCGCCCAGTGTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCGCCTCCCAGGTTCAAGCGATTCTCCCACCTC AGCCTCCTGAGTTGGGTCCTACAGGCGCACACGACCACGCCCAGCTAATTTTTTGTATTTTTAGTAGAGTTGGGGTTTCACCATGTTAGC CAGGATGGTCTCGATCTCCTGACCTCGTGATCCACTCACCTCAGCCTCCCAAAATCCTGGGGTTACAGATGTGAGCTACCACTCACGGCC CAAATCTTCTTGATCATATGTTTAAATATATTTTTTAATATTTGGAGCATGAGTTGTCACTTCTTGTTTGCCTTTTTTATAAGGAAATGT TGGAGAGTTACATCATTGCTAATGTAGAAATGTTAAGTGGAAAAATATACAGTTTGGTAAAATAAACTAGATTCTACATTTATTTGTGGG TTTTTTTCCCCTCCTTTCTTTCCACAGCACTTTTGATATCAAGCAAGTGGCTTCCTTTTTGAGATATTAAAAAAAAAAAGAAAAGGAAAA AAGTAAATGAAGCCCAACTACCTAACCCTTTCTTATTTGTATTTGTTTTAGTATTGTGAAGTTGTGTTAAATAGTACTAGCTAGAAATAC AAATTTCTGGTTATCATTTCTCTTCCCTGTGGCACTTGACATTTTAATTGTCTTAAAGTTTTTGAAGTACATCTTCTGGCCCCTTGAGTA CTGCCAGAGGCAAAAGATGTTTGTTTCTTATTCATTCCACTTTTGTCTCCTGGGATCCCTTCTGTAGCCTAAAGTATGGCTGGGAAATGG ACTTGAGAAGATTGGCTTGAATTAGATCATAATCATGTGTGATCCCATCATGAATTCATTGGAATTTGTGTTGCATGTAAGGCAATCTTT CCTGTTGTAAATCTTCCTTTTTTAATGTACATATATTTTGAAAAATATGAATAAACATGAAATTTTAAAAGCTGCTGAACCGTAGCTTAT >7403_7403_1_ATF1-HP1BP3_ATF1_chr12_51208222_ENST00000262053_HP1BP3_chr1_21100103_ENST00000312239_length(amino acids)=662AA_BP=225 MIMEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENSGV SAAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQT YQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNSEKDQSKEKEKKVKKTIPSWATLSASQLARAQKQTPMASSPRPKM DAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAV DPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSL MEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDS RDEDEDEDESSEEDSEDEEPPPKRRLQKKTPAKSPGKAASVKQRGSKPAPKVSAAQRGKARPLPKKAPPKAKTPAKKTRPSSTVIKKPSG -------------------------------------------------------------- >7403_7403_2_ATF1-HP1BP3_ATF1_chr12_51208222_ENST00000539132_HP1BP3_chr1_21100103_ENST00000312239_length(transcript)=4042nt_BP=594nt TCCGCGCCTCGGTGCAGAGCTGCGCTGCGCCCTTCCAGTCGTGCGTCTCCTCCTTTCCCTCGCCCCCAAATAAAAAGACGAGGTCTTGCT ACATTGTCCAGGATGGAGAAGTAGGAATTCTTAAGGATATTGTTATGGAGGGAAAAAAATCATTGATTATGGAAGATTCCCACAAGAGTA CCACGTCAGAGACAGCACCTCAACCTGGTTCAGCAGTTCAGGGAGCTCACATTTCTCATATTGCTCAACAGTTGCCATTGCCCCAAATGG AGCCTTACAGTTGGCAAGTCCAGGCACAGATGGAGTACAGGGACTTCAGACATTAACCATGACAAATTCAGGCAGTACTCAGCAAGGTAC AACTATTCTTCAGTATGCACAGACCTCTGATGGACAGCAGATACTTGTGCCCAGCAATCAGGTGGTCGTACAAACTGCATCAGGAGATAT GCAAACATATCAGATCCGAACTACACCTTCAGCTACTTCTCTGCCACAAACTGTGGTGATGACATCTCCTGTGACTCTCACCTCTCAGAC AACTAAGACAGATGACCCCCAATTGAAAAGAGAAATAAGGTTAATGAAAAACAGTGAGAAAGATCAGTCTAAAGAAAAGGAGAAGAAAGT GAAAAAAACAATTCCTTCCTGGGCTACCCTTTCTGCCAGCCAGCTAGCCAGGGCCCAGAAACAAACACCGATGGCTTCTTCCCCACGTCC CAAGATGGATGCAATCTTAACTGAGGCCATTAAGGCATGCTTCCAGAAGAGTGGTGCATCAGTGGTTGCTATTCGAAAATACATCATCCA TAAGTATCCTTCTCTGGAGCTGGAGAGAAGGGGTTATCTCCTTAAACAAGCACTGAAAAGAGAATTAAATAGAGGAGTCATCAAACAGGT TAAAGGAAAAGGTGCTTCTGGAAGTTTTGTTGTGGTTCAGAAATCAAGAAAAACACCTCAGAAATCCAGAAACAGAAAGAATAGGAGCTC TGCAGTGGATCCAGAACCACAAGTAAAATTGGAGGATGTCCTCCCACTGGCCTTTACTCGCCTTTGTGAACCTAAAGAAGCTTCCTACAG TCTCATCAGGAAATATGTGTCTCAGTATTATCCTAAGCTTAGAGTGGACATCAGGCCTCAGCTGTTGAAGAACGCTCTGCAGAGAGCAGT AGAGAGGGGCCAGTTAGAACAGATAACTGGCAAAGGTGCTTCGGGGACATTCCAGCTGAAGAAATCAGGGGAGAAACCCCTGCTTGGTGG AAGCCTGATGGAATATGCAATCTTGTCTGCCATTGCTGCCATGAATGAGCCGAAGACCTGCTCTACCACTGCTCTGAAGAAGTATGTCCT AGAGAATCACCCAGGAACCAATTCTAACTATCAAATGCATTTGCTGAAAAAAACCCTGCAGAAATGCGAAAAGAATGGGTGGATGGAACA GATCTCTGGGAAAGGGTTCAGTGGCACCTTCCAGCTCTGTTTTCCCTATTATCCCAGCCCAGGAGTTCTGTTTCCGAAGAAAGAGCCAGA TGATTCTAGAGATGAGGATGAAGATGAAGATGAGTCATCAGAAGAAGACTCTGAGGATGAAGAGCCGCCACCTAAGAGAAGGTTGCAGAA GAAAACCCCAGCCAAGTCCCCAGGGAAGGCCGCATCTGTGAAGCAGAGAGGGTCCAAACCTGCACCTAAAGTCTCAGCTGCCCAGCGGGG GAAAGCTAGGCCCTTGCCTAAGAAAGCACCTCCTAAGGCCAAAACGCCTGCCAAGAAGACCAGACCCTCATCCACAGTCATCAAGAAACC TAGTGGTGGCTCCTCAAAGAAGCCTGCAACCAGTGCAAGAAAGGAAGTAAAATTGCCGGGCAAGGGCAAATCCACCATGAAGAAGTCTTT CAGAGTGAAAAAGTAAATTTTATAGGAAAAAAGGGTATCATGATGAAATTCAAAATCTTATTTTCTAAGGTCAGTGTGCATTTGTTTAGT TTTGATGCTTTTCAAATTACATTATTTTCCTCCCCTATGAACATTGTGGGGAGGGACTCTAAATAAACCAGTTTAGGCATTTGCTAGCTT TAGGTGCTTTTATTGGTGCCTGCCCTTTTCCTTGTTCATTTTAATTTCTGCAATAATCCTGGACTTTCCTAAACTATGTAATGTATACTT GTCCTTTTTCTCTGCCTCCCCCAACCCCCTGTTGTTTTTATGGTCAGCTTTGCCTTTTTTTTTTCTTCCAATTTTATCTAAACAGTTGCA GAGATTTTTATATTTGTAGAAAGCATCAAGAACGGTATGCCAGTCAGGTCCTGGAAGTAAAATGGAGGCACAATATAGCACTGACTGAGT TGTAAAGCCTCCTGCCTGGAGACTTCAGTTATAGCTGTAATAATTAATCTTATTTATAAAAGCCACTCCACTAACCTTTTCTCTCCAACT GTAAACACAGAGACAGCTTTGGGAATAAGCCAAAAACAGGGTGATCTCATTAGATTTTGAAGATATATGACTCCTTTGGGCTACATTTCA TATTGATCAATTTCTAGGTATTTTTCACTGGCCCAAAGTATTGCATTCCCTTAACAGCAAGCACAAGTTCTCTATATCACTTGTTTTTTG TTGTTGTTGTTGTTGTCGTCGTTGTTTTGAGACGGAGTCTTGCTCAGGTGCCCCGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCT CCACCTCCTGGGTTCAAGCAATTCTCCTGCTTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTACCACCACGCCTGGCAATTTTTTTG TATTTTTAGTAGAGATGGGGTTTCGCCGTGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAA GTGCTGGGATTACAGGAGTGAGCCACTGTGCCTGGCCTATCCCACTTGGTTTTTGACTGAAGGGGAAGTGTAGAAATATATTGATTTGTG ATTTCTGGTGTCACCTGTGTTACCAAAAATCAAAACAAATCTTTTTTATTTTTTATTATTATTATTATTTTTGAGACAGAGTCTCGCTCT GTCGCCCAGTGTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCGCCTCCCAGGTTCAAGCGATTCTCCCACCTCAGCCTCCTG AGTTGGGTCCTACAGGCGCACACGACCACGCCCAGCTAATTTTTTGTATTTTTAGTAGAGTTGGGGTTTCACCATGTTAGCCAGGATGGT CTCGATCTCCTGACCTCGTGATCCACTCACCTCAGCCTCCCAAAATCCTGGGGTTACAGATGTGAGCTACCACTCACGGCCCAAATCTTC TTGATCATATGTTTAAATATATTTTTTAATATTTGGAGCATGAGTTGTCACTTCTTGTTTGCCTTTTTTATAAGGAAATGTTGGAGAGTT ACATCATTGCTAATGTAGAAATGTTAAGTGGAAAAATATACAGTTTGGTAAAATAAACTAGATTCTACATTTATTTGTGGGTTTTTTTCC CCTCCTTTCTTTCCACAGCACTTTTGATATCAAGCAAGTGGCTTCCTTTTTGAGATATTAAAAAAAAAAAGAAAAGGAAAAAAGTAAATG AAGCCCAACTACCTAACCCTTTCTTATTTGTATTTGTTTTAGTATTGTGAAGTTGTGTTAAATAGTACTAGCTAGAAATACAAATTTCTG GTTATCATTTCTCTTCCCTGTGGCACTTGACATTTTAATTGTCTTAAAGTTTTTGAAGTACATCTTCTGGCCCCTTGAGTACTGCCAGAG GCAAAAGATGTTTGTTTCTTATTCATTCCACTTTTGTCTCCTGGGATCCCTTCTGTAGCCTAAAGTATGGCTGGGAAATGGACTTGAGAA GATTGGCTTGAATTAGATCATAATCATGTGTGATCCCATCATGAATTCATTGGAATTTGTGTTGCATGTAAGGCAATCTTTCCTGTTGTA >7403_7403_2_ATF1-HP1BP3_ATF1_chr12_51208222_ENST00000539132_HP1BP3_chr1_21100103_ENST00000312239_length(amino acids)=541AA_BP=104 MASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKT DDPQLKREIRLMKNSEKDQSKEKEKKVKKTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYP SLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIR KYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENH PGTNSNYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKKTP AKSPGKAASVKQRGSKPAPKVSAAQRGKARPLPKKAPPKAKTPAKKTRPSSTVIKKPSGGSSKKPATSARKEVKLPGKGKSTMKKSFRVK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ATF1-HP1BP3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ATF1-HP1BP3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ATF1-HP1BP3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ATF1 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
| Hgene | ATF1 | C0206651 | Clear Cell Sarcoma of Soft Tissue | 1 | ORPHANET |
| Hgene | ATF1 | C1136382 | Sclerocystic Ovaries | 1 | CTD_human |
| Tgene | C0221074 | Depression, Postpartum | 1 | PSYGENET |
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