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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NARS-DAXX (FusionGDB2 ID:HG4677TG1616)

Fusion Gene Summary for NARS-DAXX

check button Fusion gene summary
Fusion gene informationFusion gene name: NARS-DAXX
Fusion gene ID: hg4677tg1616
HgeneTgene
Gene symbol

NARS

DAXX

Gene ID

4677

1616

Gene nameasparaginyl-tRNA synthetase 1death domain associated protein
SynonymsASNRS|NARSBING2|DAP6|EAP1|SMIM40
Cytomap('NARS')('DAXX')

18q21.31

6p21.32

Type of geneprotein-codingprotein-coding
Descriptionasparagine--tRNA ligase, cytoplasmicasparagine tRNA ligase 1, cytoplasmicasparaginyl-tRNA synthetase, cytoplasmicdeath domain-associated protein 6CENP-C binding proteinETS1-associated protein 1Fas-binding proteindeath-associated protein 6fas death domain-associated protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000256854, ENST00000423481, 
Fusion gene scores* DoF score6 X 6 X 2=727 X 4 X 5=140
# samples 67
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NARS [Title/Abstract] AND DAXX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNARS(55269587)-DAXX(33288237), # samples:1
Anticipated loss of major functional domain due to fusion event.NARS-DAXX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NARS-DAXX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NARS-DAXX seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NARS-DAXX seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
NARS-DAXX seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NARS-DAXX seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNARS

GO:0006421

asparaginyl-tRNA aminoacylation

9421509

HgeneNARS

GO:0016477

cell migration

9421509

TgeneDAXX

GO:0006334

nucleosome assembly

20504901|20651253

TgeneDAXX

GO:0006338

chromatin remodeling

20651253

TgeneDAXX

GO:0006355

regulation of transcription, DNA-templated

15878163

TgeneDAXX

GO:0030521

androgen receptor signaling pathway

15572661

TgeneDAXX

GO:0031396

regulation of protein ubiquitination

18566590

TgeneDAXX

GO:0034605

cellular response to heat

15016915

TgeneDAXX

GO:0034620

cellular response to unfolded protein

15016915

TgeneDAXX

GO:0045892

negative regulation of transcription, DNA-templated

12140263|15572661

TgeneDAXX

GO:0071276

cellular response to cadmium ion

15016915

TgeneDAXX

GO:0071280

cellular response to copper ion

15016915

TgeneDAXX

GO:0072738

cellular response to diamide

15016915

TgeneDAXX

GO:1903936

cellular response to sodium arsenite

15016915


check buttonFusion gene breakpoints across NARS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DAXX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PD-01ANARSchr18

55269587

-DAXXchr6

33288237

-


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Fusion Gene ORF analysis for NARS-DAXX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000256854ENST00000477162NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-5UTRENST00000423481ENST00000477162NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000256854ENST00000383062NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000256854ENST00000383194NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000256854ENST00000399060NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000256854ENST00000399344NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000256854ENST00000414388NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000256854ENST00000433482NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000256854ENST00000436311NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000256854ENST00000445009NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000256854ENST00000455860NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000256854ENST00000461796NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000256854ENST00000469277NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000256854ENST00000472399NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000256854ENST00000494562NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000423481ENST00000383062NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000423481ENST00000383194NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000423481ENST00000399060NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000423481ENST00000399344NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000423481ENST00000414388NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000423481ENST00000433482NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000423481ENST00000436311NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000423481ENST00000445009NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000423481ENST00000455860NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000423481ENST00000461796NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000423481ENST00000469277NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000423481ENST00000472399NARSchr18

55269587

-DAXXchr6

33288237

-
5CDS-intronENST00000423481ENST00000494562NARSchr18

55269587

-DAXXchr6

33288237

-
Frame-shiftENST00000256854ENST00000266000NARSchr18

55269587

-DAXXchr6

33288237

-
Frame-shiftENST00000256854ENST00000374542NARSchr18

55269587

-DAXXchr6

33288237

-
Frame-shiftENST00000256854ENST00000414083NARSchr18

55269587

-DAXXchr6

33288237

-
In-frameENST00000423481ENST00000266000NARSchr18

55269587

-DAXXchr6

33288237

-
In-frameENST00000423481ENST00000374542NARSchr18

55269587

-DAXXchr6

33288237

-
In-frameENST00000423481ENST00000414083NARSchr18

55269587

-DAXXchr6

33288237

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000423481NARSchr1855269587-ENST00000266000DAXXchr633288237-2412117415722411280
ENST00000423481NARSchr1855269587-ENST00000374542DAXXchr633288237-2412117415722411280
ENST00000423481NARSchr1855269587-ENST00000414083DAXXchr633288237-2251117414112250280

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000423481ENST00000266000NARSchr1855269587-DAXXchr633288237-0.0054659480.994534
ENST00000423481ENST00000374542NARSchr1855269587-DAXXchr633288237-0.0054659480.994534
ENST00000423481ENST00000414083NARSchr1855269587-DAXXchr633288237-0.0058338930.99416614

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Fusion Genomic Features for NARS-DAXX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for NARS-DAXX


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:55269587/chr6:33288237)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDAXXchr18:55269587chr6:33288237ENST0000026600008180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000026600008358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000026600008430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000037454208180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000037454208358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000037454208430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000038306208180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000038306208358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000038306208430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000038319408180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000038319408358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000038319408430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000039906008180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000039906008358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000039906008430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000039934408180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000039934408358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000039934408430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000041408307180_2170666.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000041408307358_3990666.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000041408307430_4890666.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000043348208180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000043348208358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000043348208430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000043631108180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000043631108358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000043631108430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000044500908180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000044500908358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000044500908430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000045586008180_2170741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000045586008358_3990741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST0000045586008430_4890741.0Coiled coilOntology_term=ECO:0000255
TgeneDAXXchr18:55269587chr6:33288237ENST000002660000811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr18:55269587chr6:33288237ENST0000026600008434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr18:55269587chr6:33288237ENST000003745420811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr18:55269587chr6:33288237ENST0000037454208434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr18:55269587chr6:33288237ENST000003830620811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr18:55269587chr6:33288237ENST0000038306208434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr18:55269587chr6:33288237ENST000003831940811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr18:55269587chr6:33288237ENST0000038319408434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr18:55269587chr6:33288237ENST000003990600811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr18:55269587chr6:33288237ENST0000039906008434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr18:55269587chr6:33288237ENST000003993440811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr18:55269587chr6:33288237ENST0000039934408434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr18:55269587chr6:33288237ENST000004140830711_160666.0Compositional biasNote=Poly-Asp
TgeneDAXXchr18:55269587chr6:33288237ENST0000041408307434_5720666.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr18:55269587chr6:33288237ENST000004334820811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr18:55269587chr6:33288237ENST0000043348208434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr18:55269587chr6:33288237ENST000004363110811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr18:55269587chr6:33288237ENST0000043631108434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr18:55269587chr6:33288237ENST000004450090811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr18:55269587chr6:33288237ENST0000044500908434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr18:55269587chr6:33288237ENST000004558600811_160741.0Compositional biasNote=Poly-Asp
TgeneDAXXchr18:55269587chr6:33288237ENST0000045586008434_5720741.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneDAXXchr18:55269587chr6:33288237ENST0000026600008391_3950741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000026600008628_6340741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000037454208391_3950741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000037454208628_6340741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000038306208391_3950741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000038306208628_6340741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000038319408391_3950741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000038319408628_6340741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000039906008391_3950741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000039906008628_6340741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000039934408391_3950741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000039934408628_6340741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000041408307391_3950666.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000041408307628_6340666.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000043348208391_3950741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000043348208628_6340741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000043631108391_3950741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000043631108628_6340741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000044500908391_3950741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000044500908628_6340741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000045586008391_3950741.0MotifNuclear localization signal
TgeneDAXXchr18:55269587chr6:33288237ENST0000045586008628_6340741.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NARS-DAXX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57289_57289_1_NARS-DAXX_NARS_chr18_55269587_ENST00000423481_DAXX_chr6_33288237_ENST00000266000_length(transcript)=2412nt_BP=1174nt
GTTGGAGTCATAAGACGGCGTCGGTGTTGCAGTCTGTGTCCTTGGAGGTGACCAGGGCCACTGCAGGCATGGTGCTAGCAGAGCTGTACG
TCTCTGACCGAGAGGGAAGCGATGCCACGGGAGATGGAACCAAGGAGAAACCATTTAAAACAGGTCTAAAGGCTTTGATGACAGTAGGGA
AAGAACCATTTCCTACCATTTACGTAGATTCACAAAAAGAAAATGAGAGGTGGAATGTTATTTCTAAATCACAGTTGAAGAACATTAAAA
AGATGTGGCATAGGGAACAAATGAAGAGTGAATCCCGGGAAAAGAAAGAGGCAGAAGATAGTTTACGAAGAGAAAAGAACCTGGAAGAAG
CAAAGAAGATTACCATTAAAAATGATCCAAGTCTCCCAGAGCCAAAATGTGTGAAGATTGGTGCTTTAGAGATCACTTCTTTGATAGGGG
GTACTATGAAGTTACTCCTCCAACATTAGTGCAAACACAAGTAGAAGGTGGTGCCACACTCTTCAAGCTTGACTATTTTGGGGAAGAGGC
ATTTTTGACTCAATCCTCTCAGTTGTACTTGGAGACCTGCCTCCCAGCCCTGGGAGATGTTTTTTGTATTGCTCAGTCATACCGGGCAGA
GCAGTCCAGAACACGAAGGCACCTGGCTGAGTACACTCACGTGGAAGCTGAGTGTCCTTTCCTGACTTTTGACGACCTCCTGAACCGGTT
GGAGGACTTGGTTTGTGATGTGGTAGATCGAATATTGAAGTCACCTGCAGGGAGCATAGTGCATGAGCTCAACCCGAACTTTCAGCCCCC
CAAACGGCCTTTCAAACGGATGAACTATTCAGATGCTATCGTTTGGCTAAAAGAACATGATGTAAAGAAAGAAGATGGAACTTTCTATGA
ATTTGGAGAAGATATCCCAGAAGCTCCTGAGAGACTGATGACAGACACCATTAATGAACCAATCTTGCTGTGTCGATTTCCTGTGGAGAT
CAAGTCCTTCTACATGCAGCGATGTCCTGAGGATTCCCGTCTTACTGAATCTGTCGACGTGTTGATGCCCAATGTTGGTGAGATTGTGGG
AGGCTCAATGCGTATCTTTGATAGTGAAGAAATACTGGCAGGTTATAAAAGGGAAGGGATTGACCCCACTCCCTATTACTGGTATACGGA
TCAGACAAGTGTGGCCACACAATGCGATCCAGAAGAGATCATCGTGCTCTCAGACTCTGATTAGCTGCCTCCCCTTCTCCCTGCCTCCAG
AATGTTCTGGGATAACATTTGGAGGAAGGTGGGAAGCAGATGACTGAGGAAGGGATGGACTAAGCTAATCCCCTTTTGGTGGTGTTTCTT
TAAAAAAAAAAAAAAGCTTAAGTTTTACACAGAAACATTAATAAACAATAAAGTTCTTTTCTTACTGTACTATGTGGAAAGGCAAAGGTC
AGTGCATGAGAAGAATGGGAAAAAGATATGTACCCTGCCCAGCCCACCTTCCCCCTTGGCTTCCTTGGCCCCAGTTGCTGATTCCTCCAC
GAGGGTGGACTCTCCCAGCCATGGCCTGGTGACCAGCTCCCTCTGCATCCCTTCTCCAGCCCGGCTGTCCCAAACCCCCCATTCACAGCC
TCCTCGGCCTGGTACTTGCAAGGTAAAGATGGAGACAAGAGCCCCATGTCCTCACTACAGATCTCCAATGAAAAGAACCTGGAACCTGGC
AAACAGATCAGCAGATCTTCAGGGGAGCAGCAAAACAAAGGACGCATAGTGTCACCATCGTTACTGTCAGAAGAACCCCTGGCCCCCTCC
AGCATAGATGCTGAAAGCAATGGAGAACAGCCTGAGGAGCTGACCCTGGAGGAAGAAAGCCCTGTGTCTCAGCTCTTTGAGCTAGAGATT
GAAGCTTTGCCCCTGGATACCCCTTCCTCTGTGGAGACGGACATTTCCTCTTCCAGGAAGCAATCAGAGGAGCCCTTCACCACTGTCTTA
GAGAATGGAGCAGGCATGGTCTCTTCTACTTCCTTCAATGGAGGCGTCTCTCCTCACAACTGGGGAGATTCTGGTCCCCCCTGCAAAAAA
TCTCGGAAGGAGAAGAAGCAAACAGGATCAGGGCCATTAGGAAACAGGGCCCTAGTGGAATGGCATCCCAGGGGTGCCCTTCTGCCTCCA
GAGCTGAGACAGATGACGAAGACGATGAGGAGAGTGATGAGGAAGAGGAGGAGGAGGAGGAAGAAGAAGAGGAGGAGGCCACAGATTCTG
AAGAGGAGGAGGATCTGGAACAGATGCAGGAGGGTCAGGAGGATGATGAAGAGGAGGACGAAGAGGAAGAAGCAGCAGCAGAGAAAAAAG

>57289_57289_1_NARS-DAXX_NARS_chr18_55269587_ENST00000423481_DAXX_chr6_33288237_ENST00000266000_length(amino acids)=280AA_BP=253
MHPFSSPAVPNPPFTASSAWYLQGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEEL
TLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLG
NRALVEWHPRGALLPPELRQMTKTMRRVMRKRRRRRKKKRRRPQILKRRRIWNRCRRVRRMMKRRTKRKKQQQRKKRRARLQGTSSHSAD

--------------------------------------------------------------
>57289_57289_2_NARS-DAXX_NARS_chr18_55269587_ENST00000423481_DAXX_chr6_33288237_ENST00000374542_length(transcript)=2412nt_BP=1174nt
GTTGGAGTCATAAGACGGCGTCGGTGTTGCAGTCTGTGTCCTTGGAGGTGACCAGGGCCACTGCAGGCATGGTGCTAGCAGAGCTGTACG
TCTCTGACCGAGAGGGAAGCGATGCCACGGGAGATGGAACCAAGGAGAAACCATTTAAAACAGGTCTAAAGGCTTTGATGACAGTAGGGA
AAGAACCATTTCCTACCATTTACGTAGATTCACAAAAAGAAAATGAGAGGTGGAATGTTATTTCTAAATCACAGTTGAAGAACATTAAAA
AGATGTGGCATAGGGAACAAATGAAGAGTGAATCCCGGGAAAAGAAAGAGGCAGAAGATAGTTTACGAAGAGAAAAGAACCTGGAAGAAG
CAAAGAAGATTACCATTAAAAATGATCCAAGTCTCCCAGAGCCAAAATGTGTGAAGATTGGTGCTTTAGAGATCACTTCTTTGATAGGGG
GTACTATGAAGTTACTCCTCCAACATTAGTGCAAACACAAGTAGAAGGTGGTGCCACACTCTTCAAGCTTGACTATTTTGGGGAAGAGGC
ATTTTTGACTCAATCCTCTCAGTTGTACTTGGAGACCTGCCTCCCAGCCCTGGGAGATGTTTTTTGTATTGCTCAGTCATACCGGGCAGA
GCAGTCCAGAACACGAAGGCACCTGGCTGAGTACACTCACGTGGAAGCTGAGTGTCCTTTCCTGACTTTTGACGACCTCCTGAACCGGTT
GGAGGACTTGGTTTGTGATGTGGTAGATCGAATATTGAAGTCACCTGCAGGGAGCATAGTGCATGAGCTCAACCCGAACTTTCAGCCCCC
CAAACGGCCTTTCAAACGGATGAACTATTCAGATGCTATCGTTTGGCTAAAAGAACATGATGTAAAGAAAGAAGATGGAACTTTCTATGA
ATTTGGAGAAGATATCCCAGAAGCTCCTGAGAGACTGATGACAGACACCATTAATGAACCAATCTTGCTGTGTCGATTTCCTGTGGAGAT
CAAGTCCTTCTACATGCAGCGATGTCCTGAGGATTCCCGTCTTACTGAATCTGTCGACGTGTTGATGCCCAATGTTGGTGAGATTGTGGG
AGGCTCAATGCGTATCTTTGATAGTGAAGAAATACTGGCAGGTTATAAAAGGGAAGGGATTGACCCCACTCCCTATTACTGGTATACGGA
TCAGACAAGTGTGGCCACACAATGCGATCCAGAAGAGATCATCGTGCTCTCAGACTCTGATTAGCTGCCTCCCCTTCTCCCTGCCTCCAG
AATGTTCTGGGATAACATTTGGAGGAAGGTGGGAAGCAGATGACTGAGGAAGGGATGGACTAAGCTAATCCCCTTTTGGTGGTGTTTCTT
TAAAAAAAAAAAAAAGCTTAAGTTTTACACAGAAACATTAATAAACAATAAAGTTCTTTTCTTACTGTACTATGTGGAAAGGCAAAGGTC
AGTGCATGAGAAGAATGGGAAAAAGATATGTACCCTGCCCAGCCCACCTTCCCCCTTGGCTTCCTTGGCCCCAGTTGCTGATTCCTCCAC
GAGGGTGGACTCTCCCAGCCATGGCCTGGTGACCAGCTCCCTCTGCATCCCTTCTCCAGCCCGGCTGTCCCAAACCCCCCATTCACAGCC
TCCTCGGCCTGGTACTTGCAAGGTAAAGATGGAGACAAGAGCCCCATGTCCTCACTACAGATCTCCAATGAAAAGAACCTGGAACCTGGC
AAACAGATCAGCAGATCTTCAGGGGAGCAGCAAAACAAAGGACGCATAGTGTCACCATCGTTACTGTCAGAAGAACCCCTGGCCCCCTCC
AGCATAGATGCTGAAAGCAATGGAGAACAGCCTGAGGAGCTGACCCTGGAGGAAGAAAGCCCTGTGTCTCAGCTCTTTGAGCTAGAGATT
GAAGCTTTGCCCCTGGATACCCCTTCCTCTGTGGAGACGGACATTTCCTCTTCCAGGAAGCAATCAGAGGAGCCCTTCACCACTGTCTTA
GAGAATGGAGCAGGCATGGTCTCTTCTACTTCCTTCAATGGAGGCGTCTCTCCTCACAACTGGGGAGATTCTGGTCCCCCCTGCAAAAAA
TCTCGGAAGGAGAAGAAGCAAACAGGATCAGGGCCATTAGGAAACAGGGCCCTAGTGGAATGGCATCCCAGGGGTGCCCTTCTGCCTCCA
GAGCTGAGACAGATGACGAAGACGATGAGGAGAGTGATGAGGAAGAGGAGGAGGAGGAGGAAGAAGAAGAGGAGGAGGCCACAGATTCTG
AAGAGGAGGAGGATCTGGAACAGATGCAGGAGGGTCAGGAGGATGATGAAGAGGAGGACGAAGAGGAAGAAGCAGCAGCAGAGAAAAAAG

>57289_57289_2_NARS-DAXX_NARS_chr18_55269587_ENST00000423481_DAXX_chr6_33288237_ENST00000374542_length(amino acids)=280AA_BP=253
MHPFSSPAVPNPPFTASSAWYLQGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEEL
TLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLG
NRALVEWHPRGALLPPELRQMTKTMRRVMRKRRRRRKKKRRRPQILKRRRIWNRCRRVRRMMKRRTKRKKQQQRKKRRARLQGTSSHSAD

--------------------------------------------------------------
>57289_57289_3_NARS-DAXX_NARS_chr18_55269587_ENST00000423481_DAXX_chr6_33288237_ENST00000414083_length(transcript)=2251nt_BP=1174nt
GTTGGAGTCATAAGACGGCGTCGGTGTTGCAGTCTGTGTCCTTGGAGGTGACCAGGGCCACTGCAGGCATGGTGCTAGCAGAGCTGTACG
TCTCTGACCGAGAGGGAAGCGATGCCACGGGAGATGGAACCAAGGAGAAACCATTTAAAACAGGTCTAAAGGCTTTGATGACAGTAGGGA
AAGAACCATTTCCTACCATTTACGTAGATTCACAAAAAGAAAATGAGAGGTGGAATGTTATTTCTAAATCACAGTTGAAGAACATTAAAA
AGATGTGGCATAGGGAACAAATGAAGAGTGAATCCCGGGAAAAGAAAGAGGCAGAAGATAGTTTACGAAGAGAAAAGAACCTGGAAGAAG
CAAAGAAGATTACCATTAAAAATGATCCAAGTCTCCCAGAGCCAAAATGTGTGAAGATTGGTGCTTTAGAGATCACTTCTTTGATAGGGG
GTACTATGAAGTTACTCCTCCAACATTAGTGCAAACACAAGTAGAAGGTGGTGCCACACTCTTCAAGCTTGACTATTTTGGGGAAGAGGC
ATTTTTGACTCAATCCTCTCAGTTGTACTTGGAGACCTGCCTCCCAGCCCTGGGAGATGTTTTTTGTATTGCTCAGTCATACCGGGCAGA
GCAGTCCAGAACACGAAGGCACCTGGCTGAGTACACTCACGTGGAAGCTGAGTGTCCTTTCCTGACTTTTGACGACCTCCTGAACCGGTT
GGAGGACTTGGTTTGTGATGTGGTAGATCGAATATTGAAGTCACCTGCAGGGAGCATAGTGCATGAGCTCAACCCGAACTTTCAGCCCCC
CAAACGGCCTTTCAAACGGATGAACTATTCAGATGCTATCGTTTGGCTAAAAGAACATGATGTAAAGAAAGAAGATGGAACTTTCTATGA
ATTTGGAGAAGATATCCCAGAAGCTCCTGAGAGACTGATGACAGACACCATTAATGAACCAATCTTGCTGTGTCGATTTCCTGTGGAGAT
CAAGTCCTTCTACATGCAGCGATGTCCTGAGGATTCCCGTCTTACTGAATCTGTCGACGTGTTGATGCCCAATGTTGGTGAGATTGTGGG
AGGCTCAATGCGTATCTTTGATAGTGAAGAAATACTGGCAGGTTATAAAAGGGAAGGGATTGACCCCACTCCCTATTACTGGTATACGGA
TCAGACAAGTGTGGCCACACAATGCGATCCAGAAGAGATCATCGTGCTCTCAGACTCTGATTAGCTGCCTCCCCTTCTCCCTGCCTCCCT
ATGTGGAAAGGCAAAGGTCAGTGCATGAGAAGAATGGGAAAAAGATATGTACCCTGCCCAGCCCACCTTCCCCCTTGGCTTCCTTGGCCC
CAGTTGCTGATTCCTCCACGAGGGTGGACTCTCCCAGCCATGGCCTGGTGACCAGCTCCCTCTGCATCCCTTCTCCAGCCCGGCTGTCCC
AAACCCCCCATTCACAGCCTCCTCGGCCTGGTACTTGCAAGGTAAAGATGGAGACAAGAGCCCCATGTCCTCACTACAGATCTCCAATGA
AAAGAACCTGGAACCTGGCAAACAGATCAGCAGATCTTCAGGGGAGCAGCAAAACAAAGGACGCATAGTGTCACCATCGTTACTGTCAGA
AGAACCCCTGGCCCCCTCCAGCATAGATGCTGAAAGCAATGGAGAACAGCCTGAGGAGCTGACCCTGGAGGAAGAAAGCCCTGTGTCTCA
GCTCTTTGAGCTAGAGATTGAAGCTTTGCCCCTGGATACCCCTTCCTCTGTGGAGACGGACATTTCCTCTTCCAGGAAGCAATCAGAGGA
GCCCTTCACCACTGTCTTAGAGAATGGAGCAGGCATGGTCTCTTCTACTTCCTTCAATGGAGGCGTCTCTCCTCACAACTGGGGAGATTC
TGGTCCCCCCTGCAAAAAATCTCGGAAGGAGAAGAAGCAAACAGGATCAGGGCCATTAGGAAACAGGGCCCTAGTGGAATGGCATCCCAG
GGGTGCCCTTCTGCCTCCAGAGCTGAGACAGATGACGAAGACGATGAGGAGAGTGATGAGGAAGAGGAGGAGGAGGAGGAAGAAGAAGAG
GAGGAGGCCACAGATTCTGAAGAGGAGGAGGATCTGGAACAGATGCAGGAGGGTCAGGAGGATGATGAAGAGGAGGACGAAGAGGAAGAA
GCAGCAGCAGAGAAAAAAGAGAAGAGCTCGGCTCCAAGGCACCTCTTCCCACTCTGCAGACACCCCCGAAGCCTCCTTGGATTCTGGTGA

>57289_57289_3_NARS-DAXX_NARS_chr18_55269587_ENST00000423481_DAXX_chr6_33288237_ENST00000414083_length(amino acids)=280AA_BP=253
MHPFSSPAVPNPPFTASSAWYLQGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEEL
TLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLG
NRALVEWHPRGALLPPELRQMTKTMRRVMRKRRRRRKKKRRRPQILKRRRIWNRCRRVRRMMKRRTKRKKQQQRKKRRARLQGTSSHSAD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NARS-DAXX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneDAXXchr18:55269587chr6:33288237ENST0000026600008183_4170741.0histone H3.3
TgeneDAXXchr18:55269587chr6:33288237ENST0000037454208183_4170741.0histone H3.3
TgeneDAXXchr18:55269587chr6:33288237ENST0000038306208183_4170741.0histone H3.3
TgeneDAXXchr18:55269587chr6:33288237ENST0000038319408183_4170741.0histone H3.3
TgeneDAXXchr18:55269587chr6:33288237ENST0000039906008183_4170741.0histone H3.3
TgeneDAXXchr18:55269587chr6:33288237ENST0000039934408183_4170741.0histone H3.3
TgeneDAXXchr18:55269587chr6:33288237ENST0000041408307183_4170666.0histone H3.3
TgeneDAXXchr18:55269587chr6:33288237ENST0000043348208183_4170741.0histone H3.3
TgeneDAXXchr18:55269587chr6:33288237ENST0000043631108183_4170741.0histone H3.3
TgeneDAXXchr18:55269587chr6:33288237ENST0000044500908183_4170741.0histone H3.3
TgeneDAXXchr18:55269587chr6:33288237ENST0000045586008183_4170741.0histone H3.3
TgeneDAXXchr18:55269587chr6:33288237ENST0000026600008501_6250741.0MAP3K5
TgeneDAXXchr18:55269587chr6:33288237ENST0000037454208501_6250741.0MAP3K5
TgeneDAXXchr18:55269587chr6:33288237ENST0000038306208501_6250741.0MAP3K5
TgeneDAXXchr18:55269587chr6:33288237ENST0000038319408501_6250741.0MAP3K5
TgeneDAXXchr18:55269587chr6:33288237ENST0000039906008501_6250741.0MAP3K5
TgeneDAXXchr18:55269587chr6:33288237ENST0000039934408501_6250741.0MAP3K5
TgeneDAXXchr18:55269587chr6:33288237ENST0000041408307501_6250666.0MAP3K5
TgeneDAXXchr18:55269587chr6:33288237ENST0000043348208501_6250741.0MAP3K5
TgeneDAXXchr18:55269587chr6:33288237ENST0000043631108501_6250741.0MAP3K5
TgeneDAXXchr18:55269587chr6:33288237ENST0000044500908501_6250741.0MAP3K5
TgeneDAXXchr18:55269587chr6:33288237ENST0000045586008501_6250741.0MAP3K5
TgeneDAXXchr18:55269587chr6:33288237ENST0000026600008626_7400741.0SPOP
TgeneDAXXchr18:55269587chr6:33288237ENST0000037454208626_7400741.0SPOP
TgeneDAXXchr18:55269587chr6:33288237ENST0000038306208626_7400741.0SPOP
TgeneDAXXchr18:55269587chr6:33288237ENST0000038319408626_7400741.0SPOP
TgeneDAXXchr18:55269587chr6:33288237ENST0000039906008626_7400741.0SPOP
TgeneDAXXchr18:55269587chr6:33288237ENST0000039934408626_7400741.0SPOP
TgeneDAXXchr18:55269587chr6:33288237ENST0000041408307626_7400666.0SPOP
TgeneDAXXchr18:55269587chr6:33288237ENST0000043348208626_7400741.0SPOP
TgeneDAXXchr18:55269587chr6:33288237ENST0000043631108626_7400741.0SPOP
TgeneDAXXchr18:55269587chr6:33288237ENST0000044500908626_7400741.0SPOP
TgeneDAXXchr18:55269587chr6:33288237ENST0000045586008626_7400741.0SPOP


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NARS-DAXX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NARS-DAXX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0030297Pancreatic Neoplasm1CTD_human
TgeneC0206686Adrenocortical carcinoma1CTD_human
TgeneC0206754Neuroendocrine Tumors1CTD_human
TgeneC0346647Malignant neoplasm of pancreas1CTD_human