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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATM-ENPP2 (FusionGDB2 ID:HG472TG5168)

Fusion Gene Summary for ATM-ENPP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ATM-ENPP2
Fusion gene ID: hg472tg5168
HgeneTgene
Gene symbol

ATM

ENPP2

Gene ID

472

5168

Gene nameATM serine/threonine kinaseectonucleotide pyrophosphatase/phosphodiesterase 2
SynonymsAT1|ATA|ATC|ATD|ATDC|ATE|TEL1|TELO1ATX|ATX-X|AUTOTAXIN|LysoPLD|NPP2|PD-IALPHA|PDNP2
Cytomap('ATM')('ENPP2')

11q22.3

8q24.12

Type of geneprotein-codingprotein-coding
Descriptionserine-protein kinase ATMA-T mutatedAT mutatedTEL1, telomere maintenance 1, homologataxia telangiectasia mutatedectonucleotide pyrophosphatase/phosphodiesterase family member 2E-NPP 2autotaxin-textracellular lysophospholipase Dphosphodiesterase I/nucleotide pyrophosphatase 2plasma lysophospholipase D
Modification date2020032220200313
UniProtAcc

Q13315

.
Ensembl transtripts involved in fusion geneENST00000278616, ENST00000452508, 
ENST00000525178, 
Fusion gene scores* DoF score5 X 5 X 4=10010 X 9 X 6=540
# samples 511
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/540*10)=-2.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATM [Title/Abstract] AND ENPP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATM(108190785)-ENPP2(120650767), # samples:1
Anticipated loss of major functional domain due to fusion event.ATM-ENPP2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ATM-ENPP2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ATM-ENPP2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ATM-ENPP2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ATM-ENPP2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ATM-ENPP2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ATM-ENPP2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATM

GO:0006468

protein phosphorylation

15916964

HgeneATM

GO:0006974

cellular response to DNA damage stimulus

9733515|16213212

HgeneATM

GO:0010212

response to ionizing radiation

9733515|11375976

HgeneATM

GO:0018105

peptidyl-serine phosphorylation

9733515|26323318

HgeneATM

GO:0046777

protein autophosphorylation

9733515|15790808

HgeneATM

GO:0071044

histone mRNA catabolic process

16086026

HgeneATM

GO:0071480

cellular response to gamma radiation

9925639|16213212

HgeneATM

GO:0071481

cellular response to X-ray

26323318

HgeneATM

GO:0071500

cellular response to nitrosative stress

23878245

TgeneENPP2

GO:0009395

phospholipid catabolic process

15280042|26371182

TgeneENPP2

GO:0030149

sphingolipid catabolic process

14500380

TgeneENPP2

GO:0030334

regulation of cell migration

1733949

TgeneENPP2

GO:0034638

phosphatidylcholine catabolic process

21240271

TgeneENPP2

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

18054784



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0908-01BATMchr11

108190785

+ENPP2chr8

120650767

-


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Fusion Gene ORF analysis for ATM-ENPP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000278616ENST00000075322ATMchr11

108190785

+ENPP2chr8

120650767

-
5CDS-intronENST00000278616ENST00000518109ATMchr11

108190785

+ENPP2chr8

120650767

-
5CDS-intronENST00000278616ENST00000522167ATMchr11

108190785

+ENPP2chr8

120650767

-
5CDS-intronENST00000278616ENST00000522826ATMchr11

108190785

+ENPP2chr8

120650767

-
5CDS-intronENST00000452508ENST00000075322ATMchr11

108190785

+ENPP2chr8

120650767

-
5CDS-intronENST00000452508ENST00000518109ATMchr11

108190785

+ENPP2chr8

120650767

-
5CDS-intronENST00000452508ENST00000522167ATMchr11

108190785

+ENPP2chr8

120650767

-
5CDS-intronENST00000452508ENST00000522826ATMchr11

108190785

+ENPP2chr8

120650767

-
Frame-shiftENST00000278616ENST00000259486ATMchr11

108190785

+ENPP2chr8

120650767

-
Frame-shiftENST00000278616ENST00000427067ATMchr11

108190785

+ENPP2chr8

120650767

-
Frame-shiftENST00000452508ENST00000259486ATMchr11

108190785

+ENPP2chr8

120650767

-
Frame-shiftENST00000452508ENST00000427067ATMchr11

108190785

+ENPP2chr8

120650767

-
intron-3CDSENST00000525178ENST00000259486ATMchr11

108190785

+ENPP2chr8

120650767

-
intron-3CDSENST00000525178ENST00000427067ATMchr11

108190785

+ENPP2chr8

120650767

-
intron-intronENST00000525178ENST00000075322ATMchr11

108190785

+ENPP2chr8

120650767

-
intron-intronENST00000525178ENST00000518109ATMchr11

108190785

+ENPP2chr8

120650767

-
intron-intronENST00000525178ENST00000522167ATMchr11

108190785

+ENPP2chr8

120650767

-
intron-intronENST00000525178ENST00000522826ATMchr11

108190785

+ENPP2chr8

120650767

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ATM-ENPP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ATM-ENPP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:108190785/:120650767)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATM

Q13315

.
FUNCTION: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:9843217, PubMed:9733515, PubMed:10550055, PubMed:10766245, PubMed:10839545, PubMed:10910365, PubMed:10802669, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:30612738, PubMed:30886146). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). {ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ATM-ENPP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ATM-ENPP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATM-ENPP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneATMQ13315DB00201CaffeineInhibitorSmall moleculeApproved

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Related Diseases for ATM-ENPP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATMC0004135Ataxia Telangiectasia37CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneATMC0009405Hereditary Nonpolyposis Colorectal Neoplasms6CLINGEN
HgeneATMC1112155Hereditary non-polyposis colorectal cancer syndrome6CLINGEN
HgeneATMC1333990Hereditary Nonpolyposis Colorectal Cancer6CLINGEN
HgeneATMC1333991Hereditary Non-Polyposis Colon Cancer Type 26CLINGEN
HgeneATMC2936783Colorectal cancer, hereditary nonpolyposis, type 16CLINGEN
HgeneATMC0346153Breast Cancer, Familial5CLINGEN
HgeneATMC0033578Prostatic Neoplasms4CTD_human
HgeneATMC0376358Malignant neoplasm of prostate4CTD_human
HgeneATMC0023434Chronic Lymphocytic Leukemia2CTD_human;ORPHANET;UNIPROT
HgeneATMC0030297Pancreatic Neoplasm2CTD_human
HgeneATMC0346647Malignant neoplasm of pancreas2CTD_human
HgeneATMC0005684Malignant neoplasm of urinary bladder1CGI;CTD_human
HgeneATMC0005695Bladder Neoplasm1CGI;CTD_human
HgeneATMC0006142Malignant neoplasm of breast1CTD_human;GENOMICS_ENGLAND
HgeneATMC0006826Malignant Neoplasms1CTD_human
HgeneATMC0007137Squamous cell carcinoma1CTD_human
HgeneATMC0007193Cardiomyopathy, Dilated1CTD_human
HgeneATMC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneATMC0016059Fibrosis1CTD_human
HgeneATMC0017638Glioma1CGI;GENOMICS_ENGLAND
HgeneATMC0021051Immunologic Deficiency Syndromes1GENOMICS_ENGLAND
HgeneATMC0023418leukemia1CGI;GENOMICS_ENGLAND
HgeneATMC0024299Lymphoma1CGI;GENOMICS_ENGLAND
HgeneATMC0024623Malignant neoplasm of stomach1CGI;CTD_human
HgeneATMC0025149Medulloblastoma1CGI;GENOMICS_ENGLAND
HgeneATMC0025202melanoma1CTD_human
HgeneATMC0027051Myocardial Infarction1CTD_human
HgeneATMC0027651Neoplasms1CTD_human
HgeneATMC0033054Prenatal Exposure Delayed Effects1CTD_human
HgeneATMC0036341Schizophrenia1PSYGENET
HgeneATMC0038356Stomach Neoplasms1CGI;CTD_human
HgeneATMC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
HgeneATMC0079774Peripheral T-Cell Lymphoma1CTD_human
HgeneATMC0086543Cataract1CTD_human
HgeneATMC0086692Benign Neoplasm1CTD_human
HgeneATMC0242698Ventricular Dysfunction, Left1CTD_human
HgeneATMC0334634Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse1CGI;GENOMICS_ENGLAND;UNIPROT
HgeneATMC0376407Granulomatous Slack Skin1CTD_human
HgeneATMC0524524Pseudoaphakia1CTD_human
HgeneATMC0555202Malignant lymphoma - lymphocytic, intermediate differentiation1ORPHANET
HgeneATMC0855095Small Lymphocytic Lymphoma1ORPHANET
HgeneATMC1449563Cardiomyopathy, Familial Idiopathic1CTD_human
HgeneATMC1510497Lens Opacities1CTD_human
HgeneATMC1623038Cirrhosis1CTD_human
HgeneATMC1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneATMC1843542T-CELL PROLYMPHOCYTIC LEUKEMIA, SOMATIC1GENOMICS_ENGLAND
HgeneATMC1868683B-CELL MALIGNANCY, LOW-GRADE1ORPHANET
HgeneATMC1876175Ataxia-Telangiectasia Variant1ORPHANET
HgeneATMC2239176Liver carcinoma1CTD_human
HgeneATMC2931456Prostate cancer, familial1CTD_human
HgeneATMC4722327PROSTATE CANCER, HEREDITARY, 11CTD_human
TgeneC0005612Birth Weight1CTD_human
TgeneC0019158Hepatitis1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0027627Neoplasm Metastasis1CTD_human
TgeneC0040136Thyroid Neoplasm1CTD_human
TgeneC0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneC0549473Thyroid carcinoma1CTD_human