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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATP1A1-CSN2 (FusionGDB2 ID:HG476TG1447)

Fusion Gene Summary for ATP1A1-CSN2

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP1A1-CSN2
Fusion gene ID: hg476tg1447
HgeneTgene
Gene symbol

ATP1A1

CSN2

Gene ID

476

1447

Gene nameATPase Na+/K+ transporting subunit alpha 1casein beta
SynonymsCMT2DD|HOMGSMR2CASB
Cytomap('ATP1A1')('CSN2')

1p13.1

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionsodium/potassium-transporting ATPase subunit alpha-1ATPase, Na+/K+ transporting, alpha 1 polypeptideNa(+)/K(+) ATPase alpha-1 subunitNa+/K+ ATPase 1Na, K-ATPase, alpha-A catalytic polypeptideNa,K-ATPase alpha-1 subunitNa,K-ATPase catalytic subunit abeta-casein
Modification date2020031320200313
UniProtAcc

P05023

.
Ensembl transtripts involved in fusion geneENST00000295598, ENST00000369496, 
ENST00000537345, ENST00000491156, 
Fusion gene scores* DoF score16 X 18 X 7=201614 X 12 X 2=336
# samples 233
** MAII scorelog2(23/2016*10)=-3.13178987255554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/336*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP1A1 [Title/Abstract] AND CSN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP1A1(116931334)-CSN2(70823366), # samples:1
Anticipated loss of major functional domain due to fusion event.ATP1A1-CSN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP1A1-CSN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP1A1

GO:0006883

cellular sodium ion homeostasis

10636900|19542013

HgeneATP1A1

GO:0030007

cellular potassium ion homeostasis

10636900|19542013

HgeneATP1A1

GO:0036376

sodium ion export across plasma membrane

10636900|19542013

HgeneATP1A1

GO:0071383

cellular response to steroid hormone stimulus

11546672

HgeneATP1A1

GO:0086009

membrane repolarization

19542013

HgeneATP1A1

GO:1903416

response to glycoside

11546672

HgeneATP1A1

GO:1990573

potassium ion import across plasma membrane

10636900|19542013

TgeneCSN2

GO:0007595

lactation

7979373

TgeneCSN2

GO:2000117

negative regulation of cysteine-type endopeptidase activity

12788072


check buttonFusion gene breakpoints across ATP1A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CSN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A1KO-01AATP1A1chr1

116931334

+CSN2chr4

70823366

-


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Fusion Gene ORF analysis for ATP1A1-CSN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000295598ENST00000353151ATP1A1chr1

116931334

+CSN2chr4

70823366

-
In-frameENST00000369496ENST00000353151ATP1A1chr1

116931334

+CSN2chr4

70823366

-
In-frameENST00000537345ENST00000353151ATP1A1chr1

116931334

+CSN2chr4

70823366

-
intron-3CDSENST00000491156ENST00000353151ATP1A1chr1

116931334

+CSN2chr4

70823366

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000295598ATP1A1chr1116931334+ENST00000353151CSN2chr470823366-1567813237818193
ENST00000537345ATP1A1chr1116931334+ENST00000353151CSN2chr470823366-1678924318929203
ENST00000369496ATP1A1chr1116931334+ENST00000353151CSN2chr470823366-1487733163738191

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000295598ENST00000353151ATP1A1chr1116931334+CSN2chr470823366-0.0024216610.9975783
ENST00000537345ENST00000353151ATP1A1chr1116931334+CSN2chr470823366-0.003112810.99688715
ENST00000369496ENST00000353151ATP1A1chr1116931334+CSN2chr470823366-0.0050834460.99491656

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Fusion Genomic Features for ATP1A1-CSN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ATP1A1-CSN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:116931334/chr4:70823366)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP1A1

P05023

.
FUNCTION: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+12382_8401024.0RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+12382_840993.0RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+12382_8401024.0RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+1231007_102301024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123109_13101024.0Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123153_28801024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123309_32001024.0Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123339_77201024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+1236_8701024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123793_80201024.0Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123824_84301024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123867_91801024.0Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123939_95101024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123971_98501024.0Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+1231007_10230993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123109_1310993.0Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123153_2880993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123309_3200993.0Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123339_7720993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+1236_870993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123793_8020993.0Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123824_8430993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123867_9180993.0Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123939_9510993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123971_9850993.0Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+1231007_102301024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123109_13101024.0Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123153_28801024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123309_32001024.0Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123339_77201024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+1236_8701024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123793_80201024.0Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123824_84301024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123867_91801024.0Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123939_95101024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123971_98501024.0Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123132_15201024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123289_30801024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123321_33801024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123773_79201024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123803_82301024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123844_86601024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+12388_10801024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123919_93801024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123952_97001024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123986_100601024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123132_1520993.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123289_3080993.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123321_3380993.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123773_7920993.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123803_8230993.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123844_8660993.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+12388_1080993.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123919_9380993.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123952_9700993.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123986_10060993.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123132_15201024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123289_30801024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123321_33801024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123773_79201024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123803_82301024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123844_86601024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+12388_10801024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123919_93801024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123952_97001024.0TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123986_100601024.0TransmembraneHelical


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Fusion Gene Sequence for ATP1A1-CSN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7779_7779_1_ATP1A1-CSN2_ATP1A1_chr1_116931334_ENST00000295598_CSN2_chr4_70823366_ENST00000353151_length(transcript)=1567nt_BP=813nt
CTGGGGCGCAGAGCAGCGGCGGGAGGAGGCGGACACGTGGCAACAGCGGTAGCAGCCCGGGCGGCGGCAGCAACAGCGGCGGCGGCATCG
GCCCGAGCCGCCGGCCGCCCTCCCACCCTCCCGCCCCGCGGCAGCCCTAGCTCCCTCCACTTGGCTCCCCTGGTCCCGCTCGCTCGGCCG
GGAGCTGCTCTGTGCTTTTCTCTCTGATTCTCCAGCGACAGGACCCGGCGCCGGGCACTGAGCACCGCCACCATGGGGAAGGGGGTTGGA
CGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGACAGGGACATGGATGAACTGAAG
AAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGCCGGGGATTAACATCTGCT
CGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATCAAGTTTTGTCGGCAGCTC
TTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCTACAGAAGAGGAACCTCAA
AACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTAATCATAACTGGTTGCTTCTCCTACTATCAAGAAGCTAAAAGTTCAAAG
ATCATGGAATCCTTCAAAAACATGGTCCCTCAGGTAAAAGGAGGAGACCGAATTCCTGCTGACCTCAGAATCATATCTGCAAATGGCTGC
AAGAATTGACTGAGACTGGAAATATGATGCCTTTTCCGTCTTTGTATCACGTTACCCCAAATTAAGTATGTTTGAATGAGTTTATATGGA
AAAAATGAACTTTGTCCCTTTATTTATTTTATATATTATGTCATTCATTTAATTTGAAATTTGACTCATGAACTATTTACATTTTCCAAA
TCTTAATTCAACTAGTACCACAGAAGTTCAATACTCATTTGGAAATGCTACAAACATATCAAACATATGTATACAAATTGTTTCTGGAAT
TGTGCTTATTTTTATTTCTTTAAGAATCTATTTCCTTTCCAGTCATTTCAATAAATTATTCTTAAGCATAGTCTAAGAAGATTTCAAAGT
TAATTTTCCCTCCTTATTTTTGGTCCCTAAAGCTAAAGACACTGTCTACACTAAGGGCAGAGTGATGCCTGTCCTTAAATCTCCAACGAT
ACCCTTTTTTGACCCTCAAATCCCAAAACTCACTGATCTTGAAAATCTGCATCTTCCTCTGCCTCTGCTCCAGCCCTTGATGCAGCAGGT
CCCTCAGCCTATTCCTCAGACTCTTGCACTTCCCCCTCAGCCCCTGTGGTCTGTTCCTCAGCCCAAAGTCCTGCCTATCCCCCAGCAAGT
GGTGCCCTACCCTCAGAGAGCTGTGCCTGTTCAAGCCCTTCTGCTCAACCAAGAACTTCTACTTAACCCCACCCACCAGATCTACCCTGT

>7779_7779_1_ATP1A1-CSN2_ATP1A1_chr1_116931334_ENST00000295598_CSN2_chr4_70823366_ENST00000353151_length(amino acids)=193AA_BP=
MSTATMGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPT
TPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQVKGGDRIP

--------------------------------------------------------------
>7779_7779_2_ATP1A1-CSN2_ATP1A1_chr1_116931334_ENST00000369496_CSN2_chr4_70823366_ENST00000353151_length(transcript)=1487nt_BP=733nt
GATATGTAATAATGTCTTTGCAAAGCAAAGAATATAAACAGTATAAAAGTACTAGCATTTAGATGTATTGTATCATTTAATCCTTAAAAA
CATGAAATGAGGTTGGCACTATTCTTTATCTCCACGCTGTGGAAGAGGAAATTGAAATGTAGAAGTTAGTAACTTGCCTAAGGATACACT
GCTGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGACAGGGACATGGA
TGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGCCGGGGATT
AACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATCAAGTTTTG
TCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCTACAGAAGA
GGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTAATCATAACTGGTTGCTTCTCCTACTATCAAGAAGCTAA
AAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCCTCAGGTAAAAGGAGGAGACCGAATTCCTGCTGACCTCAGAATCATATCTGC
AAATGGCTGCAAGAATTGACTGAGACTGGAAATATGATGCCTTTTCCGTCTTTGTATCACGTTACCCCAAATTAAGTATGTTTGAATGAG
TTTATATGGAAAAAATGAACTTTGTCCCTTTATTTATTTTATATATTATGTCATTCATTTAATTTGAAATTTGACTCATGAACTATTTAC
ATTTTCCAAATCTTAATTCAACTAGTACCACAGAAGTTCAATACTCATTTGGAAATGCTACAAACATATCAAACATATGTATACAAATTG
TTTCTGGAATTGTGCTTATTTTTATTTCTTTAAGAATCTATTTCCTTTCCAGTCATTTCAATAAATTATTCTTAAGCATAGTCTAAGAAG
ATTTCAAAGTTAATTTTCCCTCCTTATTTTTGGTCCCTAAAGCTAAAGACACTGTCTACACTAAGGGCAGAGTGATGCCTGTCCTTAAAT
CTCCAACGATACCCTTTTTTGACCCTCAAATCCCAAAACTCACTGATCTTGAAAATCTGCATCTTCCTCTGCCTCTGCTCCAGCCCTTGA
TGCAGCAGGTCCCTCAGCCTATTCCTCAGACTCTTGCACTTCCCCCTCAGCCCCTGTGGTCTGTTCCTCAGCCCAAAGTCCTGCCTATCC
CCCAGCAAGTGGTGCCCTACCCTCAGAGAGCTGTGCCTGTTCAAGCCCTTCTGCTCAACCAAGAACTTCTACTTAACCCCACCCACCAGA

>7779_7779_2_ATP1A1-CSN2_ATP1A1_chr1_116931334_ENST00000369496_CSN2_chr4_70823366_ENST00000353151_length(amino acids)=191AA_BP=
MPKDTLLVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTP
EWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQVKGGDRIPAD

--------------------------------------------------------------
>7779_7779_3_ATP1A1-CSN2_ATP1A1_chr1_116931334_ENST00000537345_CSN2_chr4_70823366_ENST00000353151_length(transcript)=1678nt_BP=924nt
AGCAGCGGGGGCGGCCCCGGGACTGAGCCGGCATCCCTGAGCCTGGCTCCCCTCCCTGCGACCGCCGTCACCTCCTTCTCCTTCCTTTTC
CCTCCGCCCTCCGTGCCCTGAGGAAAGGCGCGCTCCTCCCCTTCCCCTGGGGCGCTCCGCCGGGGCCTCCTCCCGGGCCTCCGTTCCCGC
CGCGGCCCCGGTTCCGGCGGGGGCAGCCTCCGGGTTCGGGGCTCCTTCTCCTGGGGACGCTGGGGCTTAGCTTGCTCCGCGCAGAGGCGG
CCGCCCTCCCCCAAAGAAAAAACTGGCTGCTTCTAAGTGCGAAGCCGGCTGGGCGGGCTGGTGCCAGAAAGGGTGTGTCTTCACTGCCCT
AAGATGGCCTTTAAGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGAC
AGGGACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTG
AGCCGGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGG
ATCAAGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCT
GCTACAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTAATCATAACTGGTTGCTTCTCCTACTAT
CAAGAAGCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCCTCAGGTAAAAGGAGGAGACCGAATTCCTGCTGACCTCAGA
ATCATATCTGCAAATGGCTGCAAGAATTGACTGAGACTGGAAATATGATGCCTTTTCCGTCTTTGTATCACGTTACCCCAAATTAAGTAT
GTTTGAATGAGTTTATATGGAAAAAATGAACTTTGTCCCTTTATTTATTTTATATATTATGTCATTCATTTAATTTGAAATTTGACTCAT
GAACTATTTACATTTTCCAAATCTTAATTCAACTAGTACCACAGAAGTTCAATACTCATTTGGAAATGCTACAAACATATCAAACATATG
TATACAAATTGTTTCTGGAATTGTGCTTATTTTTATTTCTTTAAGAATCTATTTCCTTTCCAGTCATTTCAATAAATTATTCTTAAGCAT
AGTCTAAGAAGATTTCAAAGTTAATTTTCCCTCCTTATTTTTGGTCCCTAAAGCTAAAGACACTGTCTACACTAAGGGCAGAGTGATGCC
TGTCCTTAAATCTCCAACGATACCCTTTTTTGACCCTCAAATCCCAAAACTCACTGATCTTGAAAATCTGCATCTTCCTCTGCCTCTGCT
CCAGCCCTTGATGCAGCAGGTCCCTCAGCCTATTCCTCAGACTCTTGCACTTCCCCCTCAGCCCCTGTGGTCTGTTCCTCAGCCCAAAGT
CCTGCCTATCCCCCAGCAAGTGGTGCCCTACCCTCAGAGAGCTGTGCCTGTTCAAGCCCTTCTGCTCAACCAAGAACTTCTACTTAACCC

>7779_7779_3_ATP1A1-CSN2_ATP1A1_chr1_116931334_ENST00000537345_CSN2_chr4_70823366_ENST00000353151_length(amino acids)=203AA_BP=
MGGLVPERVCLHCPKMAFKVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARD
GPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMV

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Fusion Gene PPI Analysis for ATP1A1-CSN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATP1A1-CSN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneATP1A1P05023DB00390DigoxinInhibitorSmall moleculeApproved
HgeneATP1A1P05023DB00511AcetyldigitoxinInhibitorSmall moleculeApproved
HgeneATP1A1P05023DB01078DeslanosideInhibitorSmall moleculeApproved
HgeneATP1A1P05023DB01092OuabainInhibitorSmall moleculeApproved
HgeneATP1A1P05023DB01119DiazoxideOtherSmall moleculeApproved
HgeneATP1A1P05023DB01158BretyliumInhibitorSmall moleculeApproved
HgeneATP1A1P05023DB01430AlmitrineBinderSmall moleculeApproved
HgeneATP1A1P05023DB13996Magnesium acetateSmall moleculeApproved
HgeneATP1A1P05023DB14500PotassiumRegulatorSmall moleculeApproved|Experimental
HgeneATP1A1P05023DB00903Etacrynic acidInhibitorSmall moleculeApproved|Investigational
HgeneATP1A1P05023DB01188CiclopiroxBinderSmall moleculeApproved|Investigational
HgeneATP1A1P05023DB01345Potassium cationSmall moleculeApproved|Investigational
HgeneATP1A1P05023DB01370AluminiumBinderSmall moleculeApproved|Investigational
HgeneATP1A1P05023DB01396DigitoxinInhibitorSmall moleculeApproved|Investigational
HgeneATP1A1P05023DB14498Potassium acetateSmall moleculeApproved|Investigational
HgeneATP1A1P05023DB14499Potassium sulfateSmall moleculeApproved|Investigational
HgeneATP1A1P05023DB14517Aluminium phosphateSmall moleculeApproved|Investigational
HgeneATP1A1P05023DB14518Aluminum acetateSmall moleculeApproved|Investigational
HgeneATP1A1P05023DB00774HydroflumethiazideInducerSmall moleculeApproved|Investigational|Withdrawn
HgeneATP1A1P05023DB01378Magnesium cationSmall moleculeApproved|Nutraceutical
HgeneATP1A1P05023DB01021TrichlormethiazideInhibitorSmall moleculeApproved|Vet_approved
HgeneATP1A1P05023DB01244BepridilInhibitorSmall moleculeApproved|Withdrawn

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Related Diseases for ATP1A1-CSN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATP1A1C0001430Adenoma2CTD_human
HgeneATP1A1C0205646Adenoma, Basal Cell2CTD_human
HgeneATP1A1C0205647Follicular adenoma2CTD_human
HgeneATP1A1C0205648Adenoma, Microcystic2CTD_human
HgeneATP1A1C0205649Adenoma, Monomorphic2CTD_human
HgeneATP1A1C0205650Papillary adenoma2CTD_human
HgeneATP1A1C0205651Adenoma, Trabecular2CTD_human
HgeneATP1A1C4747974CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2DD2GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneATP1A1C0005586Bipolar Disorder1PSYGENET
HgeneATP1A1C0017162Gastroenteritis, Transmissible, of Swine1CTD_human
HgeneATP1A1C0020428Hyperaldosteronism1CTD_human
HgeneATP1A1C0020538Hypertensive disease1CTD_human
HgeneATP1A1C0027051Myocardial Infarction1CTD_human
HgeneATP1A1C0027055Myocardial Reperfusion Injury1CTD_human
HgeneATP1A1C0036572Seizures1GENOMICS_ENGLAND
HgeneATP1A1C0042594Vestibular Diseases1CTD_human
HgeneATP1A1C0151723Hypomagnesemia1GENOMICS_ENGLAND
HgeneATP1A1C0151744Myocardial Ischemia1CTD_human
HgeneATP1A1C1384514Conn Syndrome1CTD_human
HgeneATP1A1C3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneATP1A1C4552839Hypomagnesemia, CTCAE1GENOMICS_ENGLAND
TgeneC0007097Carcinoma2CTD_human
TgeneC0024667Animal Mammary Neoplasms2CTD_human
TgeneC0024668Mammary Neoplasms, Experimental2CTD_human
TgeneC0205696Anaplastic carcinoma2CTD_human
TgeneC0205697Carcinoma, Spindle-Cell2CTD_human
TgeneC0205698Undifferentiated carcinoma2CTD_human
TgeneC0205699Carcinomatosis2CTD_human
TgeneC1257925Mammary Carcinoma, Animal2CTD_human