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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATP1B1-IL26 (FusionGDB2 ID:HG481TG55801)

Fusion Gene Summary for ATP1B1-IL26

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP1B1-IL26
Fusion gene ID: hg481tg55801
HgeneTgene
Gene symbol

ATP1B1

IL26

Gene ID

481

55801

Gene nameATPase Na+/K+ transporting subunit beta 1interleukin 26
SynonymsATP1BAK155|IL-26
Cytomap('ATP1B1')('IL26')

1q24.2

12q15

Type of geneprotein-codingprotein-coding
Descriptionsodium/potassium-transporting ATPase subunit beta-1ATPase, Na+/K+ transporting, beta 1 polypeptideBeta 1-subunit of Na(+),K(+)-ATPaseNa, K-ATPase beta-1 polypeptideadenosinetriphosphatasesodium pump subunit beta-1sodium-potassium ATPase subunit betainterleukin-26
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000367813, ENST00000367815, 
ENST00000367816, ENST00000499679, 
Fusion gene scores* DoF score11 X 12 X 7=9245 X 2 X 2=20
# samples 165
** MAII scorelog2(16/924*10)=-2.5298209465287
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATP1B1 [Title/Abstract] AND IL26 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP1B1(169080736)-IL26(68619063), # samples:2
Anticipated loss of major functional domain due to fusion event.ATP1B1-IL26 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ATP1B1-IL26 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP1B1

GO:0006883

cellular sodium ion homeostasis

10636900|19542013

HgeneATP1B1

GO:0030007

cellular potassium ion homeostasis

10636900|19542013

HgeneATP1B1

GO:0032781

positive regulation of ATPase activity

10636900

HgeneATP1B1

GO:0036376

sodium ion export across plasma membrane

10636900|19542013

HgeneATP1B1

GO:0046034

ATP metabolic process

23954377

HgeneATP1B1

GO:0050821

protein stabilization

10636900

HgeneATP1B1

GO:0072659

protein localization to plasma membrane

18522992

HgeneATP1B1

GO:0086009

membrane repolarization

19542013

HgeneATP1B1

GO:1901018

positive regulation of potassium ion transmembrane transporter activity

10636900

HgeneATP1B1

GO:1903278

positive regulation of sodium ion export across plasma membrane

10636900

HgeneATP1B1

GO:1903288

positive regulation of potassium ion import

10636900

HgeneATP1B1

GO:1990573

potassium ion import across plasma membrane

10636900|19542013

TgeneIL26

GO:0032874

positive regulation of stress-activated MAPK cascade

18483078

TgeneIL26

GO:0045944

positive regulation of transcription by RNA polymerase II

18483078

TgeneIL26

GO:0046427

positive regulation of JAK-STAT cascade

18483078

TgeneIL26

GO:0050680

negative regulation of epithelial cell proliferation

18483078

TgeneIL26

GO:0050715

positive regulation of cytokine secretion

18483078

TgeneIL26

GO:0051897

positive regulation of protein kinase B signaling

18483078

TgeneIL26

GO:0070374

positive regulation of ERK1 and ERK2 cascade

18483078



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1KU-01AATP1B1chr1

169080736

-IL26chr12

68619063

-
ChimerDB4SARCTCGA-DX-A1KU-01AATP1B1chr1

169080736

+IL26chr12

68619063

-


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Fusion Gene ORF analysis for ATP1B1-IL26

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000367813ENST00000229134ATP1B1chr1

169080736

+IL26chr12

68619063

-
Frame-shiftENST00000367815ENST00000229134ATP1B1chr1

169080736

+IL26chr12

68619063

-
Frame-shiftENST00000367816ENST00000229134ATP1B1chr1

169080736

+IL26chr12

68619063

-
Frame-shiftENST00000499679ENST00000229134ATP1B1chr1

169080736

+IL26chr12

68619063

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ATP1B1-IL26


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ATP1B1-IL26


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:169080736/:68619063)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ATP1B1-IL26


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ATP1B1-IL26


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATP1B1-IL26


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATP1B1-IL26


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATP1B1C0013146Drug abuse1CTD_human
HgeneATP1B1C0013170Drug habituation1CTD_human
HgeneATP1B1C0013222Drug Use Disorders1CTD_human
HgeneATP1B1C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneATP1B1C0026998Acute Myeloid Leukemia, M11CTD_human
HgeneATP1B1C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneATP1B1C0038580Substance Dependence1CTD_human
HgeneATP1B1C0038586Substance Use Disorders1CTD_human
HgeneATP1B1C0236969Substance-Related Disorders1CTD_human
HgeneATP1B1C0740858Substance abuse problem1CTD_human
HgeneATP1B1C1510472Drug Dependence1CTD_human
HgeneATP1B1C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneATP1B1C4316881Prescription Drug Abuse1CTD_human