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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:NPM1-ALK (FusionGDB2 ID:HG4869TG238) |
Fusion Gene Summary for NPM1-ALK |
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Fusion gene information | Fusion gene name: NPM1-ALK | Fusion gene ID: hg4869tg238 | Hgene | Tgene | Gene symbol | NPM1 | ALK | Gene ID | 4869 | 238 |
Gene name | nucleophosmin 1 | ALK receptor tyrosine kinase | |
Synonyms | B23|NPM | CD246|NBLST3 | |
Cytomap | ('NPM1')('ALK') 5q35.1 | 2p23.2-p23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | nucleophosminnucleolar protein NO38nucleophosmin (nucleolar phosphoprotein B23, numatrin)nucleophosmin/nucleoplasmin family, member 1testicular tissue protein Li 128 | ALK tyrosine kinase receptorCD246 antigenanaplastic lymphoma receptor tyrosine kinasemutant anaplastic lymphoma kinase | |
Modification date | 20200329 | 20200329 | |
UniProtAcc | P06748 | Q9UM73 | |
Ensembl transtripts involved in fusion gene | ENST00000296930, ENST00000351986, ENST00000393820, ENST00000517671, | ||
Fusion gene scores | * DoF score | 21 X 25 X 6=3150 | 56 X 74 X 20=82880 |
# samples | 32 | 57 | |
** MAII score | log2(32/3150*10)=-3.29920801838728 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(57/82880*10)=-7.18391827352181 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NPM1 [Title/Abstract] AND ALK [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | NPM1(170818803)-ALK(29446396), # samples:4 | ||
Anticipated loss of major functional domain due to fusion event. | NPM1-ALK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NPM1-ALK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NPM1-ALK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NPM1-ALK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NPM1-ALK seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. NPM1-ALK seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. NPM1-ALK seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. NPM1-ALK seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. NPM1-ALK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. NPM1-ALK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NPM1 | GO:0006281 | DNA repair | 19188445 |
Hgene | NPM1 | GO:0006334 | nucleosome assembly | 11602260 |
Hgene | NPM1 | GO:0006913 | nucleocytoplasmic transport | 16041368 |
Hgene | NPM1 | GO:0008104 | protein localization | 18420587 |
Hgene | NPM1 | GO:0008284 | positive regulation of cell proliferation | 22528486 |
Hgene | NPM1 | GO:0032071 | regulation of endodeoxyribonuclease activity | 19188445 |
Hgene | NPM1 | GO:0034644 | cellular response to UV | 19160485 |
Hgene | NPM1 | GO:0043066 | negative regulation of apoptotic process | 12882984 |
Hgene | NPM1 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation | 12882984 |
Hgene | NPM1 | GO:0045727 | positive regulation of translation | 12882984 |
Hgene | NPM1 | GO:0045893 | positive regulation of transcription, DNA-templated | 22528486 |
Hgene | NPM1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19160485 |
Hgene | NPM1 | GO:0060699 | regulation of endoribonuclease activity | 19188445 |
Hgene | NPM1 | GO:0060735 | regulation of eIF2 alpha phosphorylation by dsRNA | 12882984 |
Hgene | NPM1 | GO:1902751 | positive regulation of cell cycle G2/M phase transition | 22528486 |
Tgene | ALK | GO:0016310 | phosphorylation | 9174053 |
Tgene | ALK | GO:0046777 | protein autophosphorylation | 9174053 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | anaplastic large cell lymphoma;Hodgkin disease;npn Hodgkin lymphoma | D45915 | NPM1 | chr5 | 170818803 | ALK | chr2 | 29415642 | ||
ChimerKB3 | . | . | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29415642 | - |
ChimerKB3 | . | . | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29416090 | - |
ChimerKB3 | . | . | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29432744 | - |
ChimerKB3 | . | . | NPM1 | chr5 | 170819820 | + | ALK | chr2 | 29446394 | - |
ChimerKB4 | . | . | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29416090 | - |
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Fusion Gene ORF analysis for NPM1-ALK |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000296930 | ENST00000389048 | NPM1 | chr5 | 170818803 | ALK | chr2 | 29415642 | ||
5CDS-intron | ENST00000296930 | ENST00000389048 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29415642 | - |
5CDS-intron | ENST00000296930 | ENST00000431873 | NPM1 | chr5 | 170818803 | ALK | chr2 | 29415642 | ||
5CDS-intron | ENST00000296930 | ENST00000431873 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29415642 | - |
5CDS-intron | ENST00000296930 | ENST00000431873 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29416090 | - |
5CDS-intron | ENST00000296930 | ENST00000431873 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29432744 | - |
5CDS-intron | ENST00000296930 | ENST00000431873 | NPM1 | chr5 | 170819820 | + | ALK | chr2 | 29446394 | - |
5CDS-intron | ENST00000296930 | ENST00000498037 | NPM1 | chr5 | 170818803 | ALK | chr2 | 29415642 | ||
5CDS-intron | ENST00000296930 | ENST00000498037 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29415642 | - |
5CDS-intron | ENST00000296930 | ENST00000498037 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29416090 | - |
5CDS-intron | ENST00000296930 | ENST00000498037 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29432744 | - |
5CDS-intron | ENST00000296930 | ENST00000498037 | NPM1 | chr5 | 170819820 | + | ALK | chr2 | 29446394 | - |
5CDS-intron | ENST00000351986 | ENST00000389048 | NPM1 | chr5 | 170818803 | ALK | chr2 | 29415642 | ||
5CDS-intron | ENST00000351986 | ENST00000389048 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29415642 | - |
5CDS-intron | ENST00000351986 | ENST00000431873 | NPM1 | chr5 | 170818803 | ALK | chr2 | 29415642 | ||
5CDS-intron | ENST00000351986 | ENST00000431873 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29415642 | - |
5CDS-intron | ENST00000351986 | ENST00000431873 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29416090 | - |
5CDS-intron | ENST00000351986 | ENST00000431873 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29432744 | - |
5CDS-intron | ENST00000351986 | ENST00000431873 | NPM1 | chr5 | 170819820 | + | ALK | chr2 | 29446394 | - |
5CDS-intron | ENST00000351986 | ENST00000498037 | NPM1 | chr5 | 170818803 | ALK | chr2 | 29415642 | ||
5CDS-intron | ENST00000351986 | ENST00000498037 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29415642 | - |
5CDS-intron | ENST00000351986 | ENST00000498037 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29416090 | - |
5CDS-intron | ENST00000351986 | ENST00000498037 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29432744 | - |
5CDS-intron | ENST00000351986 | ENST00000498037 | NPM1 | chr5 | 170819820 | + | ALK | chr2 | 29446394 | - |
5CDS-intron | ENST00000393820 | ENST00000389048 | NPM1 | chr5 | 170818803 | ALK | chr2 | 29415642 | ||
5CDS-intron | ENST00000393820 | ENST00000389048 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29415642 | - |
5CDS-intron | ENST00000393820 | ENST00000431873 | NPM1 | chr5 | 170818803 | ALK | chr2 | 29415642 | ||
5CDS-intron | ENST00000393820 | ENST00000431873 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29415642 | - |
5CDS-intron | ENST00000393820 | ENST00000431873 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29416090 | - |
5CDS-intron | ENST00000393820 | ENST00000431873 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29432744 | - |
5CDS-intron | ENST00000393820 | ENST00000431873 | NPM1 | chr5 | 170819820 | + | ALK | chr2 | 29446394 | - |
5CDS-intron | ENST00000393820 | ENST00000498037 | NPM1 | chr5 | 170818803 | ALK | chr2 | 29415642 | ||
5CDS-intron | ENST00000393820 | ENST00000498037 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29415642 | - |
5CDS-intron | ENST00000393820 | ENST00000498037 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29416090 | - |
5CDS-intron | ENST00000393820 | ENST00000498037 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29432744 | - |
5CDS-intron | ENST00000393820 | ENST00000498037 | NPM1 | chr5 | 170819820 | + | ALK | chr2 | 29446394 | - |
5CDS-intron | ENST00000517671 | ENST00000389048 | NPM1 | chr5 | 170818803 | ALK | chr2 | 29415642 | ||
5CDS-intron | ENST00000517671 | ENST00000389048 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29415642 | - |
5CDS-intron | ENST00000517671 | ENST00000431873 | NPM1 | chr5 | 170818803 | ALK | chr2 | 29415642 | ||
5CDS-intron | ENST00000517671 | ENST00000431873 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29415642 | - |
5CDS-intron | ENST00000517671 | ENST00000431873 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29416090 | - |
5CDS-intron | ENST00000517671 | ENST00000431873 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29432744 | - |
5CDS-intron | ENST00000517671 | ENST00000431873 | NPM1 | chr5 | 170819820 | + | ALK | chr2 | 29446394 | - |
5CDS-intron | ENST00000517671 | ENST00000498037 | NPM1 | chr5 | 170818803 | ALK | chr2 | 29415642 | ||
5CDS-intron | ENST00000517671 | ENST00000498037 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29415642 | - |
5CDS-intron | ENST00000517671 | ENST00000498037 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29416090 | - |
5CDS-intron | ENST00000517671 | ENST00000498037 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29432744 | - |
5CDS-intron | ENST00000517671 | ENST00000498037 | NPM1 | chr5 | 170819820 | + | ALK | chr2 | 29446394 | - |
Frame-shift | ENST00000296930 | ENST00000389048 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29416090 | - |
Frame-shift | ENST00000296930 | ENST00000389048 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29432744 | - |
Frame-shift | ENST00000296930 | ENST00000389048 | NPM1 | chr5 | 170819820 | + | ALK | chr2 | 29446394 | - |
Frame-shift | ENST00000351986 | ENST00000389048 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29416090 | - |
Frame-shift | ENST00000351986 | ENST00000389048 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29432744 | - |
Frame-shift | ENST00000351986 | ENST00000389048 | NPM1 | chr5 | 170819820 | + | ALK | chr2 | 29446394 | - |
Frame-shift | ENST00000393820 | ENST00000389048 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29416090 | - |
Frame-shift | ENST00000393820 | ENST00000389048 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29432744 | - |
Frame-shift | ENST00000393820 | ENST00000389048 | NPM1 | chr5 | 170819820 | + | ALK | chr2 | 29446394 | - |
Frame-shift | ENST00000517671 | ENST00000389048 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29416090 | - |
Frame-shift | ENST00000517671 | ENST00000389048 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29432744 | - |
Frame-shift | ENST00000517671 | ENST00000389048 | NPM1 | chr5 | 170819820 | + | ALK | chr2 | 29446394 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000517671 | ENST00000389048 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29446396 | - | 0.002362132 | 0.99763787 |
ENST00000296930 | ENST00000389048 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29446396 | - | 0.001957753 | 0.9980422 |
ENST00000351986 | ENST00000389048 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29446396 | - | 0.002376777 | 0.99762326 |
ENST00000393820 | ENST00000389048 | NPM1 | chr5 | 170818803 | + | ALK | chr2 | 29446396 | - | 0.002370775 | 0.9976292 |
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Fusion Genomic Features for NPM1-ALK |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for NPM1-ALK |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:170818803/chr2:29446396) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
NPM1 | ALK |
FUNCTION: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). {ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. | FUNCTION: Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. Thinness gene involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). {ECO:0000250|UniProtKB:P97793, ECO:0000269|PubMed:11121404, ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:11387242, ECO:0000269|PubMed:11809760, ECO:0000269|PubMed:12107166, ECO:0000269|PubMed:12122009, ECO:0000269|PubMed:15226403, ECO:0000269|PubMed:15908427, ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:17274988}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000296930 | + | 4 | 11 | 1_9 | 117 | 295.0 | Compositional bias | Note=Met-rich |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000351986 | + | 4 | 10 | 1_9 | 117 | 266.0 | Compositional bias | Note=Met-rich |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000393820 | + | 4 | 10 | 1_9 | 117 | 260.0 | Compositional bias | Note=Met-rich |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000517671 | + | 5 | 12 | 1_9 | 117 | 295.0 | Compositional bias | Note=Met-rich |
Tgene | ALK | chr5:170818803 | chr2:29446396 | ENST00000389048 | 18 | 29 | 1116_1392 | 1057 | 1621.0 | Domain | Protein kinase | |
Tgene | ALK | chr5:170818803 | chr2:29446396 | ENST00000389048 | 18 | 29 | 1197_1199 | 1057 | 1621.0 | Region | Note=Inhibitor binding | |
Tgene | ALK | chr5:170818803 | chr2:29446396 | ENST00000389048 | 18 | 29 | 1060_1620 | 1057 | 1621.0 | Topological domain | Cytoplasmic |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000296930 | + | 4 | 11 | 120_132 | 117 | 295.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000296930 | + | 4 | 11 | 161_188 | 117 | 295.0 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000351986 | + | 4 | 10 | 120_132 | 117 | 266.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000351986 | + | 4 | 10 | 161_188 | 117 | 266.0 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000393820 | + | 4 | 10 | 120_132 | 117 | 260.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000393820 | + | 4 | 10 | 161_188 | 117 | 260.0 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000517671 | + | 5 | 12 | 120_132 | 117 | 295.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000517671 | + | 5 | 12 | 161_188 | 117 | 295.0 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000296930 | + | 4 | 11 | 152_157 | 117 | 295.0 | Motif | Nuclear localization signal |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000296930 | + | 4 | 11 | 191_197 | 117 | 295.0 | Motif | Nuclear localization signal |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000351986 | + | 4 | 10 | 152_157 | 117 | 266.0 | Motif | Nuclear localization signal |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000351986 | + | 4 | 10 | 191_197 | 117 | 266.0 | Motif | Nuclear localization signal |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000393820 | + | 4 | 10 | 152_157 | 117 | 260.0 | Motif | Nuclear localization signal |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000393820 | + | 4 | 10 | 191_197 | 117 | 260.0 | Motif | Nuclear localization signal |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000517671 | + | 5 | 12 | 152_157 | 117 | 295.0 | Motif | Nuclear localization signal |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000517671 | + | 5 | 12 | 191_197 | 117 | 295.0 | Motif | Nuclear localization signal |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000296930 | + | 4 | 11 | 243_294 | 117 | 295.0 | Region | Note=Required for nucleolar localization |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000351986 | + | 4 | 10 | 243_294 | 117 | 266.0 | Region | Note=Required for nucleolar localization |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000393820 | + | 4 | 10 | 243_294 | 117 | 260.0 | Region | Note=Required for nucleolar localization |
Hgene | NPM1 | chr5:170818803 | chr2:29446396 | ENST00000517671 | + | 5 | 12 | 243_294 | 117 | 295.0 | Region | Note=Required for nucleolar localization |
Tgene | ALK | chr5:170818803 | chr2:29446396 | ENST00000389048 | 18 | 29 | 816_940 | 1057 | 1621.0 | Compositional bias | Note=Gly-rich | |
Tgene | ALK | chr5:170818803 | chr2:29446396 | ENST00000389048 | 18 | 29 | 264_427 | 1057 | 1621.0 | Domain | MAM 1 | |
Tgene | ALK | chr5:170818803 | chr2:29446396 | ENST00000389048 | 18 | 29 | 437_473 | 1057 | 1621.0 | Domain | Note=LDL-receptor class A | |
Tgene | ALK | chr5:170818803 | chr2:29446396 | ENST00000389048 | 18 | 29 | 478_636 | 1057 | 1621.0 | Domain | MAM 2 | |
Tgene | ALK | chr5:170818803 | chr2:29446396 | ENST00000389048 | 18 | 29 | 19_1038 | 1057 | 1621.0 | Topological domain | Extracellular | |
Tgene | ALK | chr5:170818803 | chr2:29446396 | ENST00000389048 | 18 | 29 | 1039_1059 | 1057 | 1621.0 | Transmembrane | Helical |
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Fusion Gene Sequence for NPM1-ALK |
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>59963_59963_1_NPM1-ALK_NPM1_chr5_170818803_ENST00000296930_ALK_chr2_29446396_ENST00000389048_length(transcript)=2794nt_BP=653nt AGTGCGCGTGCTCGGTGGGAGCCCGCGGAGTACCTGGAAGGAGGTGGGGGCGAGGTAGAAAGGAGTGGGGTTGAAAAGCGCTTGCGCAGG ACGGCTACGGTACGGGGGTGGGAGGGCTTCGGAGCACGCGCGCGGAGGCGGGACTTGGGAAGCGCTCGCGAGATCTTCAGGGTCTATATA TAAGCGCGGGGAGCCTGCGTCCTTTCCCTGGTGTGATTCCGTCCTGCGCGGTTGTTCTCTGGAGCAGCGTTCTTTTATCTCCGTCCGCCT TCTCTCCTACCTAAGTGCGTGCCGCCACCCGATGGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCCAGAACTATCTTTTCGG TTGTGAACTAAAGGCCGACAAAGATTATCACTTTAAGGTGGATAATGATGAAAATGAGCACCAGTTATCTTTAAGAACGGTCAGTTTAGG GGCTGGTGCAAAGGATGAGTTGCACATTGTTGAAGCAGAGGCAATGAATTACGAAGGCAGTCCAATTAAAGTAACACTGGCAACTTTGAA AATGTCTGTACAGCCAACGGTTTCCCTTGGGGGCTTTGAAATAACACCACCAGTGGTCTTAAGGTTGAAGTGTGGTTCAGGGCCAGTGCA TATTAGTGGACAGCACTTAGTAGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGAGCCCTGAGTACAAGCT GAGCAAGCTCCGCACCTCGACCATCATGACCGACTACAACCCCAACTACTGCTTTGCTGGCAAGACCTCCTCCATCAGTGACCTGAAGGA GGTGCCGCGGAAAAACATCACCCTCATTCGGGGTCTGGGCCATGGCGCCTTTGGGGAGGTGTATGAAGGCCAGGTGTCCGGAATGCCCAA CGACCCAAGCCCCCTGCAAGTGGCTGTGAAGACGCTGCCTGAAGTGTGCTCTGAACAGGACGAACTGGATTTCCTCATGGAAGCCCTGAT CATCAGCAAATTCAACCACCAGAACATTGTTCGCTGCATTGGGGTGAGCCTGCAATCCCTGCCCCGGTTCATCCTGCTGGAGCTCATGGC GGGGGGAGACCTCAAGTCCTTCCTCCGAGAGACCCGCCCTCGCCCGAGCCAGCCCTCCTCCCTGGCCATGCTGGACCTTCTGCACGTGGC TCGGGACATTGCCTGTGGCTGTCAGTATTTGGAGGAAAACCACTTCATCCACCGAGACATTGCTGCCAGAAACTGCCTCTTGACCTGTCC AGGCCCTGGAAGAGTGGCCAAGATTGGAGACTTCGGGATGGCCCGAGACATCTACAGGGCGAGCTACTATAGAAAGGGAGGCTGTGCCAT GCTGCCAGTTAAGTGGATGCCCCCAGAGGCCTTCATGGAAGGAATATTCACTTCTAAAACAGACACATGGTCCTTTGGAGTGCTGCTATG GGAAATCTTTTCTCTTGGATATATGCCATACCCCAGCAAAAGCAACCAGGAAGTTCTGGAGTTTGTCACCAGTGGAGGCCGGATGGACCC ACCCAAGAACTGCCCTGGGCCTGTATACCGGATAATGACTCAGTGCTGGCAACATCAGCCTGAAGACAGGCCCAACTTTGCCATCATTTT GGAGAGGATTGAATACTGCACCCAGGACCCGGATGTAATCAACACCGCTTTGCCGATAGAATATGGTCCACTTGTGGAAGAGGAAGAGAA AGTGCCTGTGAGGCCCAAGGACCCTGAGGGGGTTCCTCCTCTCCTGGTCTCTCAACAGGCAAAACGGGAGGAGGAGCGCAGCCCAGCTGC CCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCAGAGATCTCTGTTCGAGTCCCTAGAGGGCCGGC CGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTGCACAAGGTCCACGGATCCAGAAACAAGCCCAC CAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAATAATCCTATAGCAAAGAAGGAGCCACACGACAG GGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGACTTCCGGGGGCCTCACTGCTCCTAGAGCCCTC TTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGTGGGAATGTCAATTACGGCTACCAGCAACAGGG CTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTGAAAAGCAAGAATAGCATGAACCAGCCTGGGCC CTGAGCTCGGTCGCACACTCACTTCTCTTCCTTGGGATCCCTAAGACCGTGGAGGAGAGAGAGGCAATGGCTCCTTCACAAACCAGAGAC CAAATGTCACGTTTTGTTTTGTGCCAACCTATTTTGAAGTACCACCAAAAAAGCTGTATTTTGAAAATGCTTTAGAAAGGTTTTGAGCAT GGGTTCATCCTATTCTTTCGAAAGAAGAAAATATCATAAAAATGAGTGATAAATACAAGGCCCAGATGTGGTTGCATAAGGTTTTTATGC ATGTTTGTTGTATACTTCCTTATGCTTCTTTCAAATTGTGTGTGCTCTGCTTCAATGTAGTCAGAATTAGCTGCTTCTATGTTTCATAGT TGGGGTCATAGATGTTTCCTTGCCTTGTTGATGTGGACATGAGCCATTTGAGGGGAGAGGGAACGGAAATAAAGGAGTTATTTGTAATGA >59963_59963_1_NPM1-ALK_NPM1_chr5_170818803_ENST00000296930_ALK_chr2_29446396_ENST00000389048_length(amino acids)=757AA_BP=194 MKSACAGRLRYGGGRASEHARGGGTWEALARSSGSIYKRGEPASFPWCDSVLRGCSLEQRSFISVRLLSYLSACRHPMEDSMDMDMSPLR PQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLK CGSGPVHISGQHLVVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEG QVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAM LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTW SFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGP LVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVH GSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVN -------------------------------------------------------------- >59963_59963_2_NPM1-ALK_NPM1_chr5_170818803_ENST00000351986_ALK_chr2_29446396_ENST00000389048_length(transcript)=2613nt_BP=472nt AAGCGCGGGGAGCCTGCGTCCTTTCCCTGGTGTGATTCCGTCCTGCGCGGTTGTTCTCTGGAGCAGCGTTCTTTTATCTCCGTCCGCCTT CTCTCCTACCTAAGTGCGTGCCGCCACCCGATGGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCCAGAACTATCTTTTCGGT TGTGAACTAAAGGCCGACAAAGATTATCACTTTAAGGTGGATAATGATGAAAATGAGCACCAGTTATCTTTAAGAACGGTCAGTTTAGGG GCTGGTGCAAAGGATGAGTTGCACATTGTTGAAGCAGAGGCAATGAATTACGAAGGCAGTCCAATTAAAGTAACACTGGCAACTTTGAAA ATGTCTGTACAGCCAACGGTTTCCCTTGGGGGCTTTGAAATAACACCACCAGTGGTCTTAAGGTTGAAGTGTGGTTCAGGGCCAGTGCAT ATTAGTGGACAGCACTTAGTAGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGAGCCCTGAGTACAAGCTG AGCAAGCTCCGCACCTCGACCATCATGACCGACTACAACCCCAACTACTGCTTTGCTGGCAAGACCTCCTCCATCAGTGACCTGAAGGAG GTGCCGCGGAAAAACATCACCCTCATTCGGGGTCTGGGCCATGGCGCCTTTGGGGAGGTGTATGAAGGCCAGGTGTCCGGAATGCCCAAC GACCCAAGCCCCCTGCAAGTGGCTGTGAAGACGCTGCCTGAAGTGTGCTCTGAACAGGACGAACTGGATTTCCTCATGGAAGCCCTGATC ATCAGCAAATTCAACCACCAGAACATTGTTCGCTGCATTGGGGTGAGCCTGCAATCCCTGCCCCGGTTCATCCTGCTGGAGCTCATGGCG GGGGGAGACCTCAAGTCCTTCCTCCGAGAGACCCGCCCTCGCCCGAGCCAGCCCTCCTCCCTGGCCATGCTGGACCTTCTGCACGTGGCT CGGGACATTGCCTGTGGCTGTCAGTATTTGGAGGAAAACCACTTCATCCACCGAGACATTGCTGCCAGAAACTGCCTCTTGACCTGTCCA GGCCCTGGAAGAGTGGCCAAGATTGGAGACTTCGGGATGGCCCGAGACATCTACAGGGCGAGCTACTATAGAAAGGGAGGCTGTGCCATG CTGCCAGTTAAGTGGATGCCCCCAGAGGCCTTCATGGAAGGAATATTCACTTCTAAAACAGACACATGGTCCTTTGGAGTGCTGCTATGG GAAATCTTTTCTCTTGGATATATGCCATACCCCAGCAAAAGCAACCAGGAAGTTCTGGAGTTTGTCACCAGTGGAGGCCGGATGGACCCA CCCAAGAACTGCCCTGGGCCTGTATACCGGATAATGACTCAGTGCTGGCAACATCAGCCTGAAGACAGGCCCAACTTTGCCATCATTTTG GAGAGGATTGAATACTGCACCCAGGACCCGGATGTAATCAACACCGCTTTGCCGATAGAATATGGTCCACTTGTGGAAGAGGAAGAGAAA GTGCCTGTGAGGCCCAAGGACCCTGAGGGGGTTCCTCCTCTCCTGGTCTCTCAACAGGCAAAACGGGAGGAGGAGCGCAGCCCAGCTGCC CCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCAGAGATCTCTGTTCGAGTCCCTAGAGGGCCGGCC GTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTGCACAAGGTCCACGGATCCAGAAACAAGCCCACC AGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAATAATCCTATAGCAAAGAAGGAGCCACACGACAGG GGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGACTTCCGGGGGCCTCACTGCTCCTAGAGCCCTCT TCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGTGGGAATGTCAATTACGGCTACCAGCAACAGGGC TTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTGAAAAGCAAGAATAGCATGAACCAGCCTGGGCCC TGAGCTCGGTCGCACACTCACTTCTCTTCCTTGGGATCCCTAAGACCGTGGAGGAGAGAGAGGCAATGGCTCCTTCACAAACCAGAGACC AAATGTCACGTTTTGTTTTGTGCCAACCTATTTTGAAGTACCACCAAAAAAGCTGTATTTTGAAAATGCTTTAGAAAGGTTTTGAGCATG GGTTCATCCTATTCTTTCGAAAGAAGAAAATATCATAAAAATGAGTGATAAATACAAGGCCCAGATGTGGTTGCATAAGGTTTTTATGCA TGTTTGTTGTATACTTCCTTATGCTTCTTTCAAATTGTGTGTGCTCTGCTTCAATGTAGTCAGAATTAGCTGCTTCTATGTTTCATAGTT GGGGTCATAGATGTTTCCTTGCCTTGTTGATGTGGACATGAGCCATTTGAGGGGAGAGGGAACGGAAATAAAGGAGTTATTTGTAATGAC >59963_59963_2_NPM1-ALK_NPM1_chr5_170818803_ENST00000351986_ALK_chr2_29446396_ENST00000389048_length(amino acids)=706AA_BP=143 MRGCSLEQRSFISVRLLSYLSACRHPMEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEA MNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNP NYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIG VSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMA RDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQ CWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAK KPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPN -------------------------------------------------------------- >59963_59963_3_NPM1-ALK_NPM1_chr5_170818803_ENST00000393820_ALK_chr2_29446396_ENST00000389048_length(transcript)=2591nt_BP=450nt TTCCCTGGTGTGATTCCGTCCTGCGCGGTTGTTCTCTGGAGCAGCGTTCTTTTATCTCCGTCCGCCTTCTCTCCTACCTAAGTGCGTGCC GCCACCCGATGGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCCAGAACTATCTTTTCGGTTGTGAACTAAAGGCCGACAAAG ATTATCACTTTAAGGTGGATAATGATGAAAATGAGCACCAGTTATCTTTAAGAACGGTCAGTTTAGGGGCTGGTGCAAAGGATGAGTTGC ACATTGTTGAAGCAGAGGCAATGAATTACGAAGGCAGTCCAATTAAAGTAACACTGGCAACTTTGAAAATGTCTGTACAGCCAACGGTTT CCCTTGGGGGCTTTGAAATAACACCACCAGTGGTCTTAAGGTTGAAGTGTGGTTCAGGGCCAGTGCATATTAGTGGACAGCACTTAGTAG TGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGAGCCCTGAGTACAAGCTGAGCAAGCTCCGCACCTCGACCA TCATGACCGACTACAACCCCAACTACTGCTTTGCTGGCAAGACCTCCTCCATCAGTGACCTGAAGGAGGTGCCGCGGAAAAACATCACCC TCATTCGGGGTCTGGGCCATGGCGCCTTTGGGGAGGTGTATGAAGGCCAGGTGTCCGGAATGCCCAACGACCCAAGCCCCCTGCAAGTGG CTGTGAAGACGCTGCCTGAAGTGTGCTCTGAACAGGACGAACTGGATTTCCTCATGGAAGCCCTGATCATCAGCAAATTCAACCACCAGA ACATTGTTCGCTGCATTGGGGTGAGCCTGCAATCCCTGCCCCGGTTCATCCTGCTGGAGCTCATGGCGGGGGGAGACCTCAAGTCCTTCC TCCGAGAGACCCGCCCTCGCCCGAGCCAGCCCTCCTCCCTGGCCATGCTGGACCTTCTGCACGTGGCTCGGGACATTGCCTGTGGCTGTC AGTATTTGGAGGAAAACCACTTCATCCACCGAGACATTGCTGCCAGAAACTGCCTCTTGACCTGTCCAGGCCCTGGAAGAGTGGCCAAGA TTGGAGACTTCGGGATGGCCCGAGACATCTACAGGGCGAGCTACTATAGAAAGGGAGGCTGTGCCATGCTGCCAGTTAAGTGGATGCCCC CAGAGGCCTTCATGGAAGGAATATTCACTTCTAAAACAGACACATGGTCCTTTGGAGTGCTGCTATGGGAAATCTTTTCTCTTGGATATA TGCCATACCCCAGCAAAAGCAACCAGGAAGTTCTGGAGTTTGTCACCAGTGGAGGCCGGATGGACCCACCCAAGAACTGCCCTGGGCCTG TATACCGGATAATGACTCAGTGCTGGCAACATCAGCCTGAAGACAGGCCCAACTTTGCCATCATTTTGGAGAGGATTGAATACTGCACCC AGGACCCGGATGTAATCAACACCGCTTTGCCGATAGAATATGGTCCACTTGTGGAAGAGGAAGAGAAAGTGCCTGTGAGGCCCAAGGACC CTGAGGGGGTTCCTCCTCTCCTGGTCTCTCAACAGGCAAAACGGGAGGAGGAGCGCAGCCCAGCTGCCCCACCACCTCTGCCTACCACCT CCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCAGAGATCTCTGTTCGAGTCCCTAGAGGGCCGGCCGTGGAAGGGGGACACGTGAATA TGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTGCACAAGGTCCACGGATCCAGAAACAAGCCCACCAGCTTGTGGAACCCAACGTACG GCTCCTGGTTTACAGAGAAACCCACCAAAAAGAATAATCCTATAGCAAAGAAGGAGCCACACGACAGGGGTAACCTGGGGCTGGAGGGAA GCTGTACTGTCCCACCTAACGTTGCAACTGGGAGACTTCCGGGGGCCTCACTGCTCCTAGAGCCCTCTTCGCTGACTGCCAATATGAAGG AGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGTGGGAATGTCAATTACGGCTACCAGCAACAGGGCTTGCCCTTAGAAGCCGCTACTG CCCCTGGAGCTGGTCATTACGAGGATACCATTCTGAAAAGCAAGAATAGCATGAACCAGCCTGGGCCCTGAGCTCGGTCGCACACTCACT TCTCTTCCTTGGGATCCCTAAGACCGTGGAGGAGAGAGAGGCAATGGCTCCTTCACAAACCAGAGACCAAATGTCACGTTTTGTTTTGTG CCAACCTATTTTGAAGTACCACCAAAAAAGCTGTATTTTGAAAATGCTTTAGAAAGGTTTTGAGCATGGGTTCATCCTATTCTTTCGAAA GAAGAAAATATCATAAAAATGAGTGATAAATACAAGGCCCAGATGTGGTTGCATAAGGTTTTTATGCATGTTTGTTGTATACTTCCTTAT GCTTCTTTCAAATTGTGTGTGCTCTGCTTCAATGTAGTCAGAATTAGCTGCTTCTATGTTTCATAGTTGGGGTCATAGATGTTTCCTTGC >59963_59963_3_NPM1-ALK_NPM1_chr5_170818803_ENST00000393820_ALK_chr2_29446396_ENST00000389048_length(amino acids)=706AA_BP=143 MRGCSLEQRSFISVRLLSYLSACRHPMEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEA MNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNP NYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIG VSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMA RDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQ CWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAK KPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPN -------------------------------------------------------------- >59963_59963_4_NPM1-ALK_NPM1_chr5_170818803_ENST00000517671_ALK_chr2_29446396_ENST00000389048_length(transcript)=2628nt_BP=487nt GGGCGATGTCCTTGCTAATTTGGAGACTGATTCAGTCCCCTTTTGGCCCCCAAGTTACGTAAAGATAAGGACTTTGGAGATGTTTTCTCA GGAAGGACAGAGCTGAAAAACAAAGTTCCTGCGTGCCGCCACCCGATGGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCCAG AACTATCTTTTCGGTTGTGAACTAAAGGCCGACAAAGATTATCACTTTAAGGTGGATAATGATGAAAATGAGCACCAGTTATCTTTAAGA ACGGTCAGTTTAGGGGCTGGTGCAAAGGATGAGTTGCACATTGTTGAAGCAGAGGCAATGAATTACGAAGGCAGTCCAATTAAAGTAACA CTGGCAACTTTGAAAATGTCTGTACAGCCAACGGTTTCCCTTGGGGGCTTTGAAATAACACCACCAGTGGTCTTAAGGTTGAAGTGTGGT TCAGGGCCAGTGCATATTAGTGGACAGCACTTAGTAGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGAGC CCTGAGTACAAGCTGAGCAAGCTCCGCACCTCGACCATCATGACCGACTACAACCCCAACTACTGCTTTGCTGGCAAGACCTCCTCCATC AGTGACCTGAAGGAGGTGCCGCGGAAAAACATCACCCTCATTCGGGGTCTGGGCCATGGCGCCTTTGGGGAGGTGTATGAAGGCCAGGTG TCCGGAATGCCCAACGACCCAAGCCCCCTGCAAGTGGCTGTGAAGACGCTGCCTGAAGTGTGCTCTGAACAGGACGAACTGGATTTCCTC ATGGAAGCCCTGATCATCAGCAAATTCAACCACCAGAACATTGTTCGCTGCATTGGGGTGAGCCTGCAATCCCTGCCCCGGTTCATCCTG CTGGAGCTCATGGCGGGGGGAGACCTCAAGTCCTTCCTCCGAGAGACCCGCCCTCGCCCGAGCCAGCCCTCCTCCCTGGCCATGCTGGAC CTTCTGCACGTGGCTCGGGACATTGCCTGTGGCTGTCAGTATTTGGAGGAAAACCACTTCATCCACCGAGACATTGCTGCCAGAAACTGC CTCTTGACCTGTCCAGGCCCTGGAAGAGTGGCCAAGATTGGAGACTTCGGGATGGCCCGAGACATCTACAGGGCGAGCTACTATAGAAAG GGAGGCTGTGCCATGCTGCCAGTTAAGTGGATGCCCCCAGAGGCCTTCATGGAAGGAATATTCACTTCTAAAACAGACACATGGTCCTTT GGAGTGCTGCTATGGGAAATCTTTTCTCTTGGATATATGCCATACCCCAGCAAAAGCAACCAGGAAGTTCTGGAGTTTGTCACCAGTGGA GGCCGGATGGACCCACCCAAGAACTGCCCTGGGCCTGTATACCGGATAATGACTCAGTGCTGGCAACATCAGCCTGAAGACAGGCCCAAC TTTGCCATCATTTTGGAGAGGATTGAATACTGCACCCAGGACCCGGATGTAATCAACACCGCTTTGCCGATAGAATATGGTCCACTTGTG GAAGAGGAAGAGAAAGTGCCTGTGAGGCCCAAGGACCCTGAGGGGGTTCCTCCTCTCCTGGTCTCTCAACAGGCAAAACGGGAGGAGGAG CGCAGCCCAGCTGCCCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCAGAGATCTCTGTTCGAGTC CCTAGAGGGCCGGCCGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTGCACAAGGTCCACGGATCC AGAAACAAGCCCACCAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAATAATCCTATAGCAAAGAAG GAGCCACACGACAGGGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGACTTCCGGGGGCCTCACTG CTCCTAGAGCCCTCTTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGTGGGAATGTCAATTACGGC TACCAGCAACAGGGCTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTGAAAAGCAAGAATAGCATG AACCAGCCTGGGCCCTGAGCTCGGTCGCACACTCACTTCTCTTCCTTGGGATCCCTAAGACCGTGGAGGAGAGAGAGGCAATGGCTCCTT CACAAACCAGAGACCAAATGTCACGTTTTGTTTTGTGCCAACCTATTTTGAAGTACCACCAAAAAAGCTGTATTTTGAAAATGCTTTAGA AAGGTTTTGAGCATGGGTTCATCCTATTCTTTCGAAAGAAGAAAATATCATAAAAATGAGTGATAAATACAAGGCCCAGATGTGGTTGCA TAAGGTTTTTATGCATGTTTGTTGTATACTTCCTTATGCTTCTTTCAAATTGTGTGTGCTCTGCTTCAATGTAGTCAGAATTAGCTGCTT CTATGTTTCATAGTTGGGGTCATAGATGTTTCCTTGCCTTGTTGATGTGGACATGAGCCATTTGAGGGGAGAGGGAACGGAAATAAAGGA >59963_59963_4_NPM1-ALK_NPM1_chr5_170818803_ENST00000517671_ALK_chr2_29446396_ENST00000389048_length(amino acids)=711AA_BP=148 MAPKLRKDKDFGDVFSGRTELKNKVPACRHPMEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHI VEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVVYRRKHQELQAMQMELQSPEYKLSKLRTSTIM TDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNI VRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIG DFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVY RIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSS GKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSC -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for NPM1-ALK |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NPM1-ALK |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | ALK | Q9UM73 | DB08865 | Crizotinib | Inhibitor | Small molecule | Approved |
Tgene | ALK | Q9UM73 | DB09063 | Ceritinib | Antagonist | Small molecule | Approved |
Tgene | ALK | Q9UM73 | DB11363 | Alectinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | ALK | Q9UM73 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | ALK | Q9UM73 | DB12130 | Lorlatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | ALK | Q9UM73 | DB12141 | Gilteritinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | ALK | Q9UM73 | DB12267 | Brigatinib | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for NPM1-ALK |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NPM1 | C0026998 | Acute Myeloid Leukemia, M1 | 6 | CTD_human;ORPHANET |
Hgene | NPM1 | C1879321 | Acute Myeloid Leukemia (AML-M2) | 6 | CTD_human;ORPHANET |
Hgene | NPM1 | C0023467 | Leukemia, Myelocytic, Acute | 5 | CGI;CTD_human |
Hgene | NPM1 | C0023487 | Acute Promyelocytic Leukemia | 2 | CGI;CTD_human;ORPHANET |
Hgene | NPM1 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
Hgene | NPM1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | NPM1 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Hgene | NPM1 | C0206182 | Lymphomatoid Papulosis | 1 | ORPHANET |
Hgene | NPM1 | C0265965 | Dyskeratosis Congenita | 1 | CTD_human;GENOMICS_ENGLAND |
Hgene | NPM1 | C1148551 | X-Linked Dyskeratosis Congenita | 1 | CTD_human |
Hgene | NPM1 | C1301362 | Primary Cutaneous Anaplastic Large Cell Lymphoma | 1 | ORPHANET |
Hgene | NPM1 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
Hgene | NPM1 | C2930974 | Acute erythroleukemia | 1 | CTD_human |
Hgene | NPM1 | C2930975 | Acute erythroleukemia - M6a subtype | 1 | CTD_human |
Hgene | NPM1 | C2930976 | Acute myeloid leukemia FAB-M6 | 1 | CTD_human |
Hgene | NPM1 | C2930977 | Acute erythroleukemia - M6b subtype | 1 | CTD_human |
Tgene | C0007131 | Non-Small Cell Lung Carcinoma | 28 | CGI;CTD_human | |
Tgene | C0027819 | Neuroblastoma | 13 | CGI;CTD_human;ORPHANET | |
Tgene | C0152013 | Adenocarcinoma of lung (disorder) | 8 | CGI;CTD_human | |
Tgene | C2751681 | NEUROBLASTOMA, SUSCEPTIBILITY TO, 3 | 8 | CLINGEN;UNIPROT | |
Tgene | C0206180 | Ki-1+ Anaplastic Large Cell Lymphoma | 6 | CGI;CTD_human | |
Tgene | C0334121 | Inflammatory Myofibroblastic Tumor | 4 | CGI;CTD_human;ORPHANET | |
Tgene | C0018199 | Granuloma, Plasma Cell | 3 | CTD_human | |
Tgene | C0007621 | Neoplastic Cell Transformation | 2 | CTD_human | |
Tgene | C0027627 | Neoplasm Metastasis | 2 | CTD_human | |
Tgene | C0238463 | Papillary thyroid carcinoma | 2 | ORPHANET | |
Tgene | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET | |
Tgene | C0006118 | Brain Neoplasms | 1 | CGI;CTD_human | |
Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human | |
Tgene | C0007134 | Renal Cell Carcinoma | 1 | CTD_human | |
Tgene | C0011570 | Mental Depression | 1 | PSYGENET | |
Tgene | C0011581 | Depressive disorder | 1 | PSYGENET | |
Tgene | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human | |
Tgene | C0036341 | Schizophrenia | 1 | PSYGENET | |
Tgene | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human | |
Tgene | C0085269 | Plasma Cell Granuloma, Pulmonary | 1 | CTD_human | |
Tgene | C0153633 | Malignant neoplasm of brain | 1 | CGI;CTD_human | |
Tgene | C0278601 | Inflammatory Breast Carcinoma | 1 | CTD_human | |
Tgene | C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | CTD_human | |
Tgene | C0496899 | Benign neoplasm of brain, unspecified | 1 | CTD_human | |
Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
Tgene | C0750974 | Brain Tumor, Primary | 1 | CTD_human | |
Tgene | C0750977 | Recurrent Brain Neoplasm | 1 | CTD_human | |
Tgene | C0750979 | Primary malignant neoplasm of brain | 1 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
Tgene | C1266042 | Chromophobe Renal Cell Carcinoma | 1 | CTD_human | |
Tgene | C1266043 | Sarcomatoid Renal Cell Carcinoma | 1 | CTD_human | |
Tgene | C1266044 | Collecting Duct Carcinoma of the Kidney | 1 | CTD_human | |
Tgene | C1306837 | Papillary Renal Cell Carcinoma | 1 | CTD_human | |
Tgene | C1332079 | Anaplastic Large Cell Lymphoma, ALK-Positive | 1 | ORPHANET | |
Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
Tgene | C1527390 | Neoplasms, Intracranial | 1 | CTD_human | |
Tgene | C2931189 | Neural crest tumor | 1 | ORPHANET | |
Tgene | C3899155 | hereditary neuroblastoma | 1 | GENOMICS_ENGLAND | |
Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |