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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:DDR2-ATF6 (FusionGDB2 ID:HG4921TG22926) |
Fusion Gene Summary for DDR2-ATF6 |
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Fusion gene information | Fusion gene name: DDR2-ATF6 | Fusion gene ID: hg4921tg22926 | Hgene | Tgene | Gene symbol | DDR2 | ATF6 | Gene ID | 4921 | 22926 |
Gene name | discoidin domain receptor tyrosine kinase 2 | activating transcription factor 6 | |
Synonyms | MIG20a|NTRKR3|TKT|TYRO10|WRCN | ACHM7|ATF6A | |
Cytomap | ('DDR2')('ATF6') 1q23.3 | 1q23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | discoidin domain-containing receptor 2CD167 antigen-like family member Bcell migration-inducing protein 20discoidin domain receptor 2discoidin domain receptor family, member 2discoidin domain-containing receptor tyrosine kinase 2hydroxyaryl-protein | cyclic AMP-dependent transcription factor ATF-6 alphacAMP-dependent transcription factor ATF-6 alpha | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | P18850 | |
Ensembl transtripts involved in fusion gene | ENST00000367921, ENST00000367922, | ||
Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 9 X 9 X 8=648 |
# samples | 4 | 12 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/648*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DDR2 [Title/Abstract] AND ATF6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | DDR2(162625164)-ATF6(161928236), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DDR2 | GO:0018108 | peptidyl-tyrosine phosphorylation | 20004161 |
Hgene | DDR2 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway | 16186108 |
Hgene | DDR2 | GO:0046777 | protein autophosphorylation | 16186108 |
Tgene | ATF6 | GO:0043065 | positive regulation of apoptotic process | 14752510 |
Tgene | ATF6 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 14973138 |
Tgene | ATF6 | GO:1903893 | positive regulation of ATF6-mediated unfolded protein response | 9837962 |
Tgene | ATF6 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 11163209|11256944|16469704 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | ACC | TCGA-OR-A5J8-01A | DDR2 | chr1 | 162625164 | + | ATF6 | chr1 | 161928236 | + |
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Fusion Gene ORF analysis for DDR2-ATF6 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000367921 | ENST00000367942 | DDR2 | chr1 | 162625164 | + | ATF6 | chr1 | 161928236 | + |
5UTR-3CDS | ENST00000367922 | ENST00000367942 | DDR2 | chr1 | 162625164 | + | ATF6 | chr1 | 161928236 | + |
5UTR-intron | ENST00000367921 | ENST00000476437 | DDR2 | chr1 | 162625164 | + | ATF6 | chr1 | 161928236 | + |
5UTR-intron | ENST00000367922 | ENST00000476437 | DDR2 | chr1 | 162625164 | + | ATF6 | chr1 | 161928236 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for DDR2-ATF6 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
DDR2 | chr1 | 162625164 | + | ATF6 | chr1 | 161928235 | + | 9.42E-06 | 0.9999906 |
DDR2 | chr1 | 162625164 | + | ATF6 | chr1 | 161928235 | + | 9.42E-06 | 0.9999906 |
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Fusion Protein Features for DDR2-ATF6 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:162625164/:161928236) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | ATF6 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: [Cyclic AMP-dependent transcription factor ATF-6 alpha]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane (PubMed:10564271, PubMed:11158310, PubMed:11779464). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:10564271, PubMed:11158310, PubMed:11779464). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11779464}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR (PubMed:10564271, PubMed:11163209, PubMed:11158310, PubMed:11779464). Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') (PubMed:10564271, PubMed:11158310, PubMed:11779464). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor (PubMed:10564271, PubMed:11158310, PubMed:11779464). May play a role in foveal development and cone function in the retina (PubMed:26029869). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11163209, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:26029869}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for DDR2-ATF6 |
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Fusion Gene PPI Analysis for DDR2-ATF6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DDR2-ATF6 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DDR2-ATF6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DDR2 | C1849011 | SPONDYLOMETAEPIPHYSEAL DYSPLASIA, SHORT LIMB-HAND TYPE | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | DDR2 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Tgene | C0152200 | Achromatopsia | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET | |
Tgene | C4225297 | ACHROMATOPSIA 7 | 2 | CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT | |
Tgene | C0003949 | Asbestosis | 1 | CTD_human | |
Tgene | C0009398 | Color vision defect | 1 | CTD_human | |
Tgene | C0022336 | Creutzfeldt-Jakob disease | 1 | CTD_human | |
Tgene | C0035334 | Retinitis Pigmentosa | 1 | CTD_human | |
Tgene | C0036457 | Scrapie | 1 | CTD_human | |
Tgene | C0085636 | Photophobia | 1 | CTD_human | |
Tgene | C0155015 | Color Blindness, Red | 1 | CTD_human | |
Tgene | C0155016 | Color Blindness, Red-Green | 1 | CTD_human | |
Tgene | C0155017 | Color Blindness, Blue | 1 | CTD_human | |
Tgene | C0155018 | Color Blindness, Acquired | 1 | CTD_human | |
Tgene | C0239777 | Color Blindness, Green | 1 | CTD_human | |
Tgene | C0242225 | Color blindness | 1 | CTD_human | |
Tgene | C0376329 | New Variant Creutzfeldt-Jakob Disease | 1 | CTD_human | |
Tgene | C0700501 | Congenital nystagmus | 1 | CTD_human | |
Tgene | C0751042 | Color Blindness, Inherited | 1 | CTD_human | |
Tgene | C0751043 | Monochromatopsia | 1 | CTD_human | |
Tgene | C0751254 | Creutzfeldt-Jakob Disease, Familial | 1 | CTD_human | |
Tgene | C2930617 | Pulmonary Fibrosis - from Asbestos Exposure | 1 | CTD_human | |
Tgene | C3489532 | Cone-Rod Dystrophy 2 | 1 | ORPHANET |