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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:NUCB1-BAX (FusionGDB2 ID:HG4924TG581) |
Fusion Gene Summary for NUCB1-BAX |
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Fusion gene information | Fusion gene name: NUCB1-BAX | Fusion gene ID: hg4924tg581 | Hgene | Tgene | Gene symbol | NUCB1 | BAX | Gene ID | 4924 | 581 |
Gene name | nucleobindin 1 | BCL2 associated X, apoptosis regulator | |
Synonyms | CALNUC|NUC | BCL2L4 | |
Cytomap | ('NUCB1')('BAX') 19q13.33 | 19q13.33 | |
Type of gene | protein-coding | protein-coding | |
Description | nucleobindin-1 | apoptosis regulator BAXBCL2 associated X proteinBCL2-associated X protein omegaBaxdelta2G9Baxdelta2G9omegaBaxdelta2omegabcl-2-like protein 4bcl2-L-4 | |
Modification date | 20200313 | 20200322 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000485798, ENST00000263273, ENST00000405315, ENST00000407032, | ||
Fusion gene scores | * DoF score | 9 X 11 X 6=594 | 4 X 3 X 3=36 |
# samples | 14 | 6 | |
** MAII score | log2(14/594*10)=-2.0850361038558 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NUCB1 [Title/Abstract] AND BAX [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | NUCB1(49404188)-BAX(49464066), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | NUCB1-BAX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NUCB1-BAX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NUCB1-BAX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NUCB1-BAX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NUCB1-BAX seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. NUCB1-BAX seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. NUCB1-BAX seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | BAX | GO:0001783 | B cell apoptotic process | 15214043|16424160 |
Tgene | BAX | GO:0001836 | release of cytochrome c from mitochondria | 9843949|16199525|17052454 |
Tgene | BAX | GO:0006915 | apoptotic process | 9660918 |
Tgene | BAX | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 11912183 |
Tgene | BAX | GO:0008053 | mitochondrial fusion | 14769861 |
Tgene | BAX | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c | 15214043 |
Tgene | BAX | GO:0008637 | apoptotic mitochondrial changes | 9843949 |
Tgene | BAX | GO:0009636 | response to toxic substance | 16307838 |
Tgene | BAX | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient | 9843949 |
Tgene | BAX | GO:0010917 | negative regulation of mitochondrial membrane potential | 16751333 |
Tgene | BAX | GO:0031334 | positive regulation of protein complex assembly | 9111042|19805544 |
Tgene | BAX | GO:0032091 | negative regulation of protein binding | 9388232 |
Tgene | BAX | GO:0032976 | release of matrix enzymes from mitochondria | 9843949 |
Tgene | BAX | GO:0043065 | positive regulation of apoptotic process | 16751333|17464193 |
Tgene | BAX | GO:0043525 | positive regulation of neuron apoptotic process | 15637643 |
Tgene | BAX | GO:0043653 | mitochondrial fragmentation involved in apoptotic process | 12499352 |
Tgene | BAX | GO:0051881 | regulation of mitochondrial membrane potential | 9843949 |
Tgene | BAX | GO:0090200 | positive regulation of release of cytochrome c from mitochondria | 14963330 |
Tgene | BAX | GO:0097190 | apoptotic signaling pathway | 16424160 |
Tgene | BAX | GO:0097191 | extrinsic apoptotic signaling pathway | 15214043 |
Tgene | BAX | GO:0097193 | intrinsic apoptotic signaling pathway | 9219694|16462759 |
Tgene | BAX | GO:1990117 | B cell receptor apoptotic signaling pathway | 15214043 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | OV | TCGA-13-0726 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
ChimerDB4 | PRAD | TCGA-HC-A76W | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
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Fusion Gene ORF analysis for NUCB1-BAX |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000485798 | ENST00000345358 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
3UTR-3CDS | ENST00000485798 | ENST00000539787 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
3UTR-3UTR | ENST00000485798 | ENST00000293288 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
3UTR-3UTR | ENST00000485798 | ENST00000354470 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
3UTR-3UTR | ENST00000485798 | ENST00000391871 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
3UTR-3UTR | ENST00000485798 | ENST00000415969 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
5CDS-3UTR | ENST00000263273 | ENST00000293288 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
5CDS-3UTR | ENST00000263273 | ENST00000354470 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
5CDS-3UTR | ENST00000263273 | ENST00000391871 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
5CDS-3UTR | ENST00000263273 | ENST00000415969 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
5CDS-3UTR | ENST00000405315 | ENST00000293288 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
5CDS-3UTR | ENST00000405315 | ENST00000354470 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
5CDS-3UTR | ENST00000405315 | ENST00000391871 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
5CDS-3UTR | ENST00000405315 | ENST00000415969 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
5CDS-3UTR | ENST00000407032 | ENST00000293288 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
5CDS-3UTR | ENST00000407032 | ENST00000354470 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
5CDS-3UTR | ENST00000407032 | ENST00000391871 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
5CDS-3UTR | ENST00000407032 | ENST00000415969 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
5UTR-3CDS | ENST00000405315 | ENST00000345358 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
5UTR-3CDS | ENST00000405315 | ENST00000539787 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
5UTR-3CDS | ENST00000407032 | ENST00000345358 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
5UTR-3CDS | ENST00000407032 | ENST00000539787 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
5UTR-3UTR | ENST00000405315 | ENST00000293288 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
5UTR-3UTR | ENST00000405315 | ENST00000354470 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
5UTR-3UTR | ENST00000405315 | ENST00000391871 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
5UTR-3UTR | ENST00000405315 | ENST00000415969 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
5UTR-3UTR | ENST00000407032 | ENST00000293288 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
5UTR-3UTR | ENST00000407032 | ENST00000354470 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
5UTR-3UTR | ENST00000407032 | ENST00000391871 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
5UTR-3UTR | ENST00000407032 | ENST00000415969 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
Frame-shift | ENST00000263273 | ENST00000539787 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
Frame-shift | ENST00000405315 | ENST00000539787 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
Frame-shift | ENST00000407032 | ENST00000539787 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
In-frame | ENST00000263273 | ENST00000345358 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
In-frame | ENST00000405315 | ENST00000345358 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
In-frame | ENST00000407032 | ENST00000345358 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
intron-3CDS | ENST00000263273 | ENST00000345358 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
intron-3CDS | ENST00000263273 | ENST00000539787 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
intron-3CDS | ENST00000485798 | ENST00000345358 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
intron-3CDS | ENST00000485798 | ENST00000539787 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
intron-3UTR | ENST00000263273 | ENST00000293288 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
intron-3UTR | ENST00000263273 | ENST00000354470 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
intron-3UTR | ENST00000263273 | ENST00000391871 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
intron-3UTR | ENST00000263273 | ENST00000415969 | NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + |
intron-3UTR | ENST00000485798 | ENST00000293288 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
intron-3UTR | ENST00000485798 | ENST00000354470 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
intron-3UTR | ENST00000485798 | ENST00000391871 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
intron-3UTR | ENST00000485798 | ENST00000415969 | NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for NUCB1-BAX |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + | 0.014194294 | 0.9858057 |
NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + | 2.73E-09 | 1 |
NUCB1 | chr19 | 49403629 | + | BAX | chr19 | 49459454 | + | 0.014194294 | 0.9858057 |
NUCB1 | chr19 | 49404188 | + | BAX | chr19 | 49464066 | + | 2.73E-09 | 1 |
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Fusion Protein Features for NUCB1-BAX |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:49404188/chr19:49464066) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000293288 | 3 | 5 | 150_165 | 123 | 219.0 | Motif | Note=BH2 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000345358 | 3 | 6 | 150_165 | 123 | 193.0 | Motif | Note=BH2 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000354470 | 2 | 5 | 150_165 | 74 | 144.0 | Motif | Note=BH2 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000354470 | 2 | 5 | 98_118 | 74 | 144.0 | Motif | Note=BH1 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000391871 | 2 | 5 | 150_165 | 105 | 88.33333333333333 | Motif | Note=BH2 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000415969 | 3 | 6 | 150_165 | 123 | 180.0 | Motif | Note=BH2 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000293288 | 3 | 5 | 172_192 | 123 | 219.0 | Transmembrane | Helical | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000345358 | 3 | 6 | 172_192 | 123 | 193.0 | Transmembrane | Helical | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000354470 | 2 | 5 | 172_192 | 74 | 144.0 | Transmembrane | Helical | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000391871 | 2 | 5 | 172_192 | 105 | 88.33333333333333 | Transmembrane | Helical | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000415969 | 3 | 6 | 172_192 | 123 | 180.0 | Transmembrane | Helical | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000539787 | 4 | 7 | 172_192 | 155 | 205.66666666666666 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000263273 | + | 1 | 12 | 253_264 | 45 | 462.0 | Calcium binding | 1 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000263273 | + | 1 | 12 | 305_316 | 45 | 462.0 | Calcium binding | 2 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000405315 | + | 2 | 13 | 253_264 | 45 | 462.0 | Calcium binding | 1 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000405315 | + | 2 | 13 | 305_316 | 45 | 462.0 | Calcium binding | 2 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000407032 | + | 2 | 14 | 253_264 | 45 | 666.6666666666666 | Calcium binding | 1 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000407032 | + | 2 | 14 | 305_316 | 45 | 666.6666666666666 | Calcium binding | 2 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000263273 | + | 1 | 12 | 150_218 | 45 | 462.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000263273 | + | 1 | 12 | 341_407 | 45 | 462.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000405315 | + | 2 | 13 | 150_218 | 45 | 462.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000405315 | + | 2 | 13 | 341_407 | 45 | 462.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000407032 | + | 2 | 14 | 150_218 | 45 | 666.6666666666666 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000407032 | + | 2 | 14 | 341_407 | 45 | 666.6666666666666 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000263273 | + | 1 | 12 | 401_407 | 45 | 462.0 | Compositional bias | Note=Poly-Gln |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000405315 | + | 2 | 13 | 401_407 | 45 | 462.0 | Compositional bias | Note=Poly-Gln |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000407032 | + | 2 | 14 | 401_407 | 45 | 666.6666666666666 | Compositional bias | Note=Poly-Gln |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000263273 | + | 1 | 12 | 172_218 | 45 | 462.0 | DNA binding | Ontology_term=ECO:0000255 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000405315 | + | 2 | 13 | 172_218 | 45 | 462.0 | DNA binding | Ontology_term=ECO:0000255 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000407032 | + | 2 | 14 | 172_218 | 45 | 666.6666666666666 | DNA binding | Ontology_term=ECO:0000255 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000263273 | + | 1 | 12 | 240_275 | 45 | 462.0 | Domain | EF-hand 1 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000263273 | + | 1 | 12 | 292_327 | 45 | 462.0 | Domain | EF-hand 2 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000405315 | + | 2 | 13 | 240_275 | 45 | 462.0 | Domain | EF-hand 1 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000405315 | + | 2 | 13 | 292_327 | 45 | 462.0 | Domain | EF-hand 2 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000407032 | + | 2 | 14 | 240_275 | 45 | 666.6666666666666 | Domain | EF-hand 1 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000407032 | + | 2 | 14 | 292_327 | 45 | 666.6666666666666 | Domain | EF-hand 2 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000263273 | + | 1 | 12 | 303_333 | 45 | 462.0 | Motif | GBA |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000405315 | + | 2 | 13 | 303_333 | 45 | 462.0 | Motif | GBA |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000407032 | + | 2 | 14 | 303_333 | 45 | 666.6666666666666 | Motif | GBA |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000263273 | + | 1 | 12 | 228_321 | 45 | 462.0 | Region | Binds to GNAI2 and GNAI3 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000263273 | + | 1 | 12 | 42_51 | 45 | 462.0 | Region | Note=O-glycosylated at one site |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000405315 | + | 2 | 13 | 228_321 | 45 | 462.0 | Region | Binds to GNAI2 and GNAI3 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000405315 | + | 2 | 13 | 42_51 | 45 | 462.0 | Region | Note=O-glycosylated at one site |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000407032 | + | 2 | 14 | 228_321 | 45 | 666.6666666666666 | Region | Binds to GNAI2 and GNAI3 |
Hgene | NUCB1 | chr19:49404188 | chr19:49464066 | ENST00000407032 | + | 2 | 14 | 42_51 | 45 | 666.6666666666666 | Region | Note=O-glycosylated at one site |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000293288 | 3 | 5 | 59_73 | 123 | 219.0 | Motif | Note=BH3 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000293288 | 3 | 5 | 98_118 | 123 | 219.0 | Motif | Note=BH1 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000345358 | 3 | 6 | 59_73 | 123 | 193.0 | Motif | Note=BH3 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000345358 | 3 | 6 | 98_118 | 123 | 193.0 | Motif | Note=BH1 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000354470 | 2 | 5 | 59_73 | 74 | 144.0 | Motif | Note=BH3 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000391871 | 2 | 5 | 59_73 | 105 | 88.33333333333333 | Motif | Note=BH3 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000391871 | 2 | 5 | 98_118 | 105 | 88.33333333333333 | Motif | Note=BH1 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000415969 | 3 | 6 | 59_73 | 123 | 180.0 | Motif | Note=BH3 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000415969 | 3 | 6 | 98_118 | 123 | 180.0 | Motif | Note=BH1 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000539787 | 4 | 7 | 150_165 | 155 | 205.66666666666666 | Motif | Note=BH2 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000539787 | 4 | 7 | 59_73 | 155 | 205.66666666666666 | Motif | Note=BH3 | |
Tgene | BAX | chr19:49404188 | chr19:49464066 | ENST00000539787 | 4 | 7 | 98_118 | 155 | 205.66666666666666 | Motif | Note=BH1 |
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Fusion Gene Sequence for NUCB1-BAX |
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Fusion Gene PPI Analysis for NUCB1-BAX |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NUCB1-BAX |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NUCB1-BAX |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NUCB1 | C0014518 | Toxic Epidermal Necrolysis | 1 | CTD_human |
Hgene | NUCB1 | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
Hgene | NUCB1 | C1274933 | Drug-Induced Stevens Johnson Syndrome | 1 | CTD_human |
Hgene | NUCB1 | C3658301 | Mycoplasma-Induced Stevens-Johnson Syndrome | 1 | CTD_human |
Hgene | NUCB1 | C3658302 | Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum | 1 | CTD_human |
Tgene | C0027051 | Myocardial Infarction | 2 | CTD_human | |
Tgene | C0002152 | Alloxan Diabetes | 1 | CTD_human | |
Tgene | C0002395 | Alzheimer's Disease | 1 | CTD_human | |
Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human | |
Tgene | C0007102 | Malignant tumor of colon | 1 | CTD_human | |
Tgene | C0009375 | Colonic Neoplasms | 1 | CTD_human | |
Tgene | C0011265 | Presenile dementia | 1 | CTD_human | |
Tgene | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human | |
Tgene | C0014859 | Esophageal Neoplasms | 1 | CTD_human | |
Tgene | C0019193 | Hepatitis, Toxic | 1 | CTD_human | |
Tgene | C0019693 | HIV Infections | 1 | CTD_human | |
Tgene | C0021364 | Male infertility | 1 | CTD_human | |
Tgene | C0021841 | Intestinal Neoplasms | 1 | CTD_human | |
Tgene | C0022116 | Ischemia | 1 | CTD_human | |
Tgene | C0022660 | Kidney Failure, Acute | 1 | CTD_human | |
Tgene | C0027055 | Myocardial Reperfusion Injury | 1 | CTD_human | |
Tgene | C0027746 | Nerve Degeneration | 1 | CTD_human | |
Tgene | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human | |
Tgene | C0033578 | Prostatic Neoplasms | 1 | CTD_human | |
Tgene | C0038433 | Streptozotocin Diabetes | 1 | CTD_human | |
Tgene | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human | |
Tgene | C0276496 | Familial Alzheimer Disease (FAD) | 1 | CTD_human | |
Tgene | C0346627 | Intestinal Cancer | 1 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human | |
Tgene | C0376407 | Granulomatous Slack Skin | 1 | CTD_human | |
Tgene | C0494463 | Alzheimer Disease, Late Onset | 1 | CTD_human | |
Tgene | C0546126 | Acute Confusional Senile Dementia | 1 | CTD_human | |
Tgene | C0546837 | Malignant neoplasm of esophagus | 1 | CTD_human | |
Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
Tgene | C0750900 | Alzheimer's Disease, Focal Onset | 1 | CTD_human | |
Tgene | C0750901 | Alzheimer Disease, Early Onset | 1 | CTD_human | |
Tgene | C0848676 | Subfertility, Male | 1 | CTD_human | |
Tgene | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human | |
Tgene | C0917731 | Male sterility | 1 | CTD_human | |
Tgene | C0920269 | Microsatellite Instability | 1 | CTD_human | |
Tgene | C1136382 | Sclerocystic Ovaries | 1 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
Tgene | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human | |
Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
Tgene | C1565662 | Acute Kidney Insufficiency | 1 | CTD_human | |
Tgene | C1721098 | Replication Error Phenotype | 1 | CTD_human | |
Tgene | C2609414 | Acute kidney injury | 1 | CTD_human | |
Tgene | C2937358 | Cerebral Hemorrhage | 1 | CTD_human | |
Tgene | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human | |
Tgene | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human | |
Tgene | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human | |
Tgene | C4505456 | HIV Coinfection | 1 | CTD_human | |
Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |