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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GPX8-TTLL1 (FusionGDB2 ID:HG493869TG25809)

Fusion Gene Summary for GPX8-TTLL1

check button Fusion gene summary
Fusion gene informationFusion gene name: GPX8-TTLL1
Fusion gene ID: hg493869tg25809
HgeneTgene
Gene symbol

GPX8

TTLL1

Gene ID

493869

25809

Gene nameglutathione peroxidase 8 (putative)tubulin tyrosine ligase like 1
SynonymsEPLA847|GPx-8|GSHPx-8|UNQ847C22orf7|HS323M22B
Cytomap('GPX8')('TTLL1')

5q11.2

22q13.2

Type of geneprotein-codingprotein-coding
Descriptionprobable glutathione peroxidase 8probable tubulin polyglutamylase TTLL1PGs3catalytic subunit of neural tubulin polyglutamylasetubulin polyglutamylase complex subunit 3tubulin tyrosine ligase-like family, member 1tubulin--tyrosine ligase-like protein 1tubulin-tyrosine ligase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000506123, ENST00000296734, 
ENST00000503787, ENST00000515370, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 8 X 6=336
# samples 213
** MAII scorelog2(2/8*10)=1.32192809488736log2(13/336*10)=-1.36994960975031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPX8 [Title/Abstract] AND TTLL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGPX8(54456071)-TTLL1(43455533), # samples:2
Anticipated loss of major functional domain due to fusion event.GPX8-TTLL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GPX8-TTLL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GPX8-TTLL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GPX8-TTLL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GPX8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TTLL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-93-8067-01AGPX8chr5

54456071

-TTLL1chr22

43455533

-
ChimerDB4LUADTCGA-93-8067-01AGPX8chr5

54456071

+TTLL1chr22

43455533

-


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Fusion Gene ORF analysis for GPX8-TTLL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000506123ENST00000266254GPX8chr5

54456071

+TTLL1chr22

43455533

-
3UTR-3CDSENST00000506123ENST00000331018GPX8chr5

54456071

+TTLL1chr22

43455533

-
3UTR-intronENST00000506123ENST00000445824GPX8chr5

54456071

+TTLL1chr22

43455533

-
5CDS-intronENST00000296734ENST00000445824GPX8chr5

54456071

+TTLL1chr22

43455533

-
5CDS-intronENST00000503787ENST00000445824GPX8chr5

54456071

+TTLL1chr22

43455533

-
5CDS-intronENST00000515370ENST00000445824GPX8chr5

54456071

+TTLL1chr22

43455533

-
In-frameENST00000296734ENST00000266254GPX8chr5

54456071

+TTLL1chr22

43455533

-
In-frameENST00000296734ENST00000331018GPX8chr5

54456071

+TTLL1chr22

43455533

-
In-frameENST00000503787ENST00000266254GPX8chr5

54456071

+TTLL1chr22

43455533

-
In-frameENST00000503787ENST00000331018GPX8chr5

54456071

+TTLL1chr22

43455533

-
In-frameENST00000515370ENST00000266254GPX8chr5

54456071

+TTLL1chr22

43455533

-
In-frameENST00000515370ENST00000331018GPX8chr5

54456071

+TTLL1chr22

43455533

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000503787GPX8chr554456071+ENST00000331018TTLL1chr2243455533-85115312590192
ENST00000503787GPX8chr554456071+ENST00000266254TTLL1chr2243455533-81015312677221
ENST00000296734GPX8chr554456071+ENST00000331018TTLL1chr2243455533-85115312590192
ENST00000296734GPX8chr554456071+ENST00000266254TTLL1chr2243455533-81015312677221
ENST00000515370GPX8chr554456071+ENST00000331018TTLL1chr2243455533-7727423511162
ENST00000515370GPX8chr554456071+ENST00000266254TTLL1chr2243455533-7317423598191

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000503787ENST00000331018GPX8chr554456071+TTLL1chr2243455533-0.87063190.12936807
ENST00000503787ENST00000266254GPX8chr554456071+TTLL1chr2243455533-0.038838150.9611618
ENST00000296734ENST00000331018GPX8chr554456071+TTLL1chr2243455533-0.87063190.12936807
ENST00000296734ENST00000266254GPX8chr554456071+TTLL1chr2243455533-0.038838150.9611618
ENST00000515370ENST00000331018GPX8chr554456071+TTLL1chr2243455533-0.0182921640.9817078
ENST00000515370ENST00000266254GPX8chr554456071+TTLL1chr2243455533-0.0126397480.9873603

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Fusion Genomic Features for GPX8-TTLL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for GPX8-TTLL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:54456071/chr22:43455533)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTTLL1chr5:54456071chr22:43455533ENST00000445824041_367060.0DomainTTL
TgeneTTLL1chr5:54456071chr22:43455533ENST0000044582404181_184060.0Nucleotide bindingATP binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPX8chr5:54456071chr22:43455533ENST00000503787+1318_400210.0TransmembraneHelical
TgeneTTLL1chr5:54456071chr22:43455533ENST000002662546111_367249424.0DomainTTL
TgeneTTLL1chr5:54456071chr22:43455533ENST000003310186101_367249395.0DomainTTL
TgeneTTLL1chr5:54456071chr22:43455533ENST00000266254611181_184249424.0Nucleotide bindingATP binding
TgeneTTLL1chr5:54456071chr22:43455533ENST00000331018610181_184249395.0Nucleotide bindingATP binding


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Fusion Gene Sequence for GPX8-TTLL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34570_34570_1_GPX8-TTLL1_GPX8_chr5_54456071_ENST00000296734_TTLL1_chr22_43455533_ENST00000266254_length(transcript)=810nt_BP=153nt
GTATTTGCAGTTTTGCTGTCTATAGTTCTATGCACAGTAACGCTATTTCTTCTACAACTAAAATTCCTCAAACCTAAAATCAACAGCTTT
TATGCCTTTGAAGTGAAGGATGCAAAAGGAAGAACTGTTTCTCTGGAAAAGTATAAAGGCAAAGAGGACTACAACCACATCCATGGGGGC
AAGTGGACAGTGAGTAACCTGCGGCTCTACCTGGAGAGCACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGATCCACTGGATC
ATCGTGCAGTCCCTGAAGGCTGTGGCGCCGGTGATGAACAATGACAAGCACTGCTTTGAATGCTATGGCTACGACATCATCATCGACGAC
AAGCTGAAGCCCTGGCTGATCGAGGTGAATGCGTCCCCGTCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCAAGTACAACCTGATT
AATGACACCCTCAACATCGCCGTCCCGAATGGTGAAATCCCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAGTCCTCGGCAATTAC
GAGATTCTGTATGATGAAGAATTGGCCCAGGGTGACGGGGCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGGGGCCCAGAGCA
GGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACCACCTGGAAGTGAGTCCCACCTGGACCTTATCAAAACTACTCACTCCACCTGGGC
CCCTGCTGAAGCCCTATTTTGAAATTTCCCTTTTGTAGAGCTTTTTTCCTTTCCTAAGCCCTGTAAATAAACGAAGGCACTTCTTTGGAA

>34570_34570_1_GPX8-TTLL1_GPX8_chr5_54456071_ENST00000296734_TTLL1_chr22_43455533_ENST00000266254_length(amino acids)=221AA_BP=47
MLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTVSLEKYKGKEDYNHIHGGKWTVSNLRLYLESTRGKEVTSKLFDEIHWIIVQS
LKAVAPVMNNDKHCFECYGYDIIIDDKLKPWLIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILY

--------------------------------------------------------------
>34570_34570_2_GPX8-TTLL1_GPX8_chr5_54456071_ENST00000296734_TTLL1_chr22_43455533_ENST00000331018_length(transcript)=851nt_BP=153nt
GTATTTGCAGTTTTGCTGTCTATAGTTCTATGCACAGTAACGCTATTTCTTCTACAACTAAAATTCCTCAAACCTAAAATCAACAGCTTT
TATGCCTTTGAAGTGAAGGATGCAAAAGGAAGAACTGTTTCTCTGGAAAAGTATAAAGGCAAAGAGGACTACAACCACATCCATGGGGGC
AAGTGGACAGTGAGTAACCTGCGGCTCTACCTGGAGAGCACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGATCCACTGGATC
ATCGTGCAGTCCCTGAAGGCTGTGGCGGTGAATGCGTCCCCGTCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCAAGTACAACCTG
ATTAATGACACCCTCAACATCGCCGTCCCGAATGGTGAAATCCCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAGTCCTCGGCAAT
TACGAGATTCTGTATGATGAAGAATTGGCCCAGGGTGACGGGGCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGGGGCCCAGA
GCAGGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACCACCTGGAAGTGAGTCCCACCTGGACCTTATCAAAACTACTCACTCCACCTG
GGCCCCTGCTGAAGCCCTATTTTGAAATTTCCCTTTTGTAGAGCTTTTTTCCTTTCCTAAGCCCTGTAAATAAACGAAGGCACTTCTTTG
GAAGGTTATGGAGTCTGTTTGACTAGTGCTAAAGGAAACAATTCATGCGGATGTATAAAACTCGCTCTTTTTTTTTTAATTTTTAACCTA

>34570_34570_2_GPX8-TTLL1_GPX8_chr5_54456071_ENST00000296734_TTLL1_chr22_43455533_ENST00000331018_length(amino acids)=192AA_BP=47
MLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTVSLEKYKGKEDYNHIHGGKWTVSNLRLYLESTRGKEVTSKLFDEIHWIIVQS
LKAVAVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILYDEELAQGDGADRELRSRQGQSLGPRAGRS

--------------------------------------------------------------
>34570_34570_3_GPX8-TTLL1_GPX8_chr5_54456071_ENST00000503787_TTLL1_chr22_43455533_ENST00000266254_length(transcript)=810nt_BP=153nt
GTATTTGCAGTTTTGCTGTCTATAGTTCTATGCACAGTAACGCTATTTCTTCTACAACTAAAATTCCTCAAACCTAAAATCAACAGCTTT
TATGCCTTTGAAGTGAAGGATGCAAAAGGAAGAACTGTTTCTCTGGAAAAGTATAAAGGCAAAGAGGACTACAACCACATCCATGGGGGC
AAGTGGACAGTGAGTAACCTGCGGCTCTACCTGGAGAGCACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGATCCACTGGATC
ATCGTGCAGTCCCTGAAGGCTGTGGCGCCGGTGATGAACAATGACAAGCACTGCTTTGAATGCTATGGCTACGACATCATCATCGACGAC
AAGCTGAAGCCCTGGCTGATCGAGGTGAATGCGTCCCCGTCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCAAGTACAACCTGATT
AATGACACCCTCAACATCGCCGTCCCGAATGGTGAAATCCCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAGTCCTCGGCAATTAC
GAGATTCTGTATGATGAAGAATTGGCCCAGGGTGACGGGGCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGGGGCCCAGAGCA
GGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACCACCTGGAAGTGAGTCCCACCTGGACCTTATCAAAACTACTCACTCCACCTGGGC
CCCTGCTGAAGCCCTATTTTGAAATTTCCCTTTTGTAGAGCTTTTTTCCTTTCCTAAGCCCTGTAAATAAACGAAGGCACTTCTTTGGAA

>34570_34570_3_GPX8-TTLL1_GPX8_chr5_54456071_ENST00000503787_TTLL1_chr22_43455533_ENST00000266254_length(amino acids)=221AA_BP=47
MLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTVSLEKYKGKEDYNHIHGGKWTVSNLRLYLESTRGKEVTSKLFDEIHWIIVQS
LKAVAPVMNNDKHCFECYGYDIIIDDKLKPWLIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILY

--------------------------------------------------------------
>34570_34570_4_GPX8-TTLL1_GPX8_chr5_54456071_ENST00000503787_TTLL1_chr22_43455533_ENST00000331018_length(transcript)=851nt_BP=153nt
GTATTTGCAGTTTTGCTGTCTATAGTTCTATGCACAGTAACGCTATTTCTTCTACAACTAAAATTCCTCAAACCTAAAATCAACAGCTTT
TATGCCTTTGAAGTGAAGGATGCAAAAGGAAGAACTGTTTCTCTGGAAAAGTATAAAGGCAAAGAGGACTACAACCACATCCATGGGGGC
AAGTGGACAGTGAGTAACCTGCGGCTCTACCTGGAGAGCACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGATCCACTGGATC
ATCGTGCAGTCCCTGAAGGCTGTGGCGGTGAATGCGTCCCCGTCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCAAGTACAACCTG
ATTAATGACACCCTCAACATCGCCGTCCCGAATGGTGAAATCCCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAGTCCTCGGCAAT
TACGAGATTCTGTATGATGAAGAATTGGCCCAGGGTGACGGGGCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGGGGCCCAGA
GCAGGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACCACCTGGAAGTGAGTCCCACCTGGACCTTATCAAAACTACTCACTCCACCTG
GGCCCCTGCTGAAGCCCTATTTTGAAATTTCCCTTTTGTAGAGCTTTTTTCCTTTCCTAAGCCCTGTAAATAAACGAAGGCACTTCTTTG
GAAGGTTATGGAGTCTGTTTGACTAGTGCTAAAGGAAACAATTCATGCGGATGTATAAAACTCGCTCTTTTTTTTTTAATTTTTAACCTA

>34570_34570_4_GPX8-TTLL1_GPX8_chr5_54456071_ENST00000503787_TTLL1_chr22_43455533_ENST00000331018_length(amino acids)=192AA_BP=47
MLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTVSLEKYKGKEDYNHIHGGKWTVSNLRLYLESTRGKEVTSKLFDEIHWIIVQS
LKAVAVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILYDEELAQGDGADRELRSRQGQSLGPRAGRS

--------------------------------------------------------------
>34570_34570_5_GPX8-TTLL1_GPX8_chr5_54456071_ENST00000515370_TTLL1_chr22_43455533_ENST00000266254_length(transcript)=731nt_BP=74nt
ACTTCCCTCTAGAATCCTCCAACATGGAGCCTCTTGCAGCTTACCCGCTAAAATGTTCCGGGCCCAGAGCAAAGGAGGACTACAACCACA
TCCATGGGGGCAAGTGGACAGTGAGTAACCTGCGGCTCTACCTGGAGAGCACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGA
TCCACTGGATCATCGTGCAGTCCCTGAAGGCTGTGGCGCCGGTGATGAACAATGACAAGCACTGCTTTGAATGCTATGGCTACGACATCA
TCATCGACGACAAGCTGAAGCCCTGGCTGATCGAGGTGAATGCGTCCCCGTCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCAAGT
ACAACCTGATTAATGACACCCTCAACATCGCCGTCCCGAATGGTGAAATCCCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAGTCC
TCGGCAATTACGAGATTCTGTATGATGAAGAATTGGCCCAGGGTGACGGGGCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGG
GGCCCAGAGCAGGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACCACCTGGAAGTGAGTCCCACCTGGACCTTATCAAAACTACTCAC
TCCACCTGGGCCCCTGCTGAAGCCCTATTTTGAAATTTCCCTTTTGTAGAGCTTTTTTCCTTTCCTAAGCCCTGTAAATAAACGAAGGCA

>34570_34570_5_GPX8-TTLL1_GPX8_chr5_54456071_ENST00000515370_TTLL1_chr22_43455533_ENST00000266254_length(amino acids)=191AA_BP=17
MEPLAAYPLKCSGPRAKEDYNHIHGGKWTVSNLRLYLESTRGKEVTSKLFDEIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDKLKP
WLIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILYDEELAQGDGADRELRSRQGQSLGPRAGRSR

--------------------------------------------------------------
>34570_34570_6_GPX8-TTLL1_GPX8_chr5_54456071_ENST00000515370_TTLL1_chr22_43455533_ENST00000331018_length(transcript)=772nt_BP=74nt
ACTTCCCTCTAGAATCCTCCAACATGGAGCCTCTTGCAGCTTACCCGCTAAAATGTTCCGGGCCCAGAGCAAAGGAGGACTACAACCACA
TCCATGGGGGCAAGTGGACAGTGAGTAACCTGCGGCTCTACCTGGAGAGCACCCGCGGCAAGGAGGTGACCAGCAAGCTGTTCGACGAGA
TCCACTGGATCATCGTGCAGTCCCTGAAGGCTGTGGCGGTGAATGCGTCCCCGTCTCTCACGTCCAGCACTGCCAATGACCGAATCCTCA
AGTACAACCTGATTAATGACACCCTCAACATCGCCGTCCCGAATGGTGAAATCCCAGACTGCAAATGGAACAAGTCGCCACCTAAGGAAG
TCCTCGGCAATTACGAGATTCTGTATGATGAAGAATTGGCCCAGGGTGACGGGGCTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTC
TGGGGCCCAGAGCAGGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACCACCTGGAAGTGAGTCCCACCTGGACCTTATCAAAACTACT
CACTCCACCTGGGCCCCTGCTGAAGCCCTATTTTGAAATTTCCCTTTTGTAGAGCTTTTTTCCTTTCCTAAGCCCTGTAAATAAACGAAG
GCACTTCTTTGGAAGGTTATGGAGTCTGTTTGACTAGTGCTAAAGGAAACAATTCATGCGGATGTATAAAACTCGCTCTTTTTTTTTTAA

>34570_34570_6_GPX8-TTLL1_GPX8_chr5_54456071_ENST00000515370_TTLL1_chr22_43455533_ENST00000331018_length(amino acids)=162AA_BP=17
MEPLAAYPLKCSGPRAKEDYNHIHGGKWTVSNLRLYLESTRGKEVTSKLFDEIHWIIVQSLKAVAVNASPSLTSSTANDRILKYNLINDT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GPX8-TTLL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GPX8-TTLL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GPX8-TTLL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGPX8C0023893Liver Cirrhosis, Experimental1CTD_human