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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ATP2B4-RBBP4 (FusionGDB2 ID:HG493TG5928) |
Fusion Gene Summary for ATP2B4-RBBP4 |
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Fusion gene information | Fusion gene name: ATP2B4-RBBP4 | Fusion gene ID: hg493tg5928 | Hgene | Tgene | Gene symbol | ATP2B4 | RBBP4 | Gene ID | 493 | 5928 |
Gene name | ATPase plasma membrane Ca2+ transporting 4 | RB binding protein 4, chromatin remodeling factor | |
Synonyms | ATP2B2|MXRA1|PMCA4|PMCA4b|PMCA4x | NURF55|RBAP48|lin-53 | |
Cytomap | ('ATP2B4')('RBBP4') 1q32.1 | 1p35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | plasma membrane calcium-transporting ATPase 4ATPase, Ca++ transporting, plasma membrane 4matrix-remodeling-associated protein 1sarcolemmal calcium pump | histone-binding protein RBBP4CAF-1 subunit CCAF-I 48 kDa subunitCAF-I p48MSI1 protein homologRBBP-4chromatin assembly factor 1 subunit Cchromatin assembly factor I p48 subunitchromatin assembly factor/CAF-1 p48 subunitnucleosome-remodeling factor | |
Modification date | 20200327 | 20200329 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000357681, ENST00000367218, ENST00000367219, ENST00000391954, ENST00000341360, ENST00000466407, | ||
Fusion gene scores | * DoF score | 14 X 5 X 8=560 | 6 X 8 X 4=192 |
# samples | 17 | 8 | |
** MAII score | log2(17/560*10)=-1.71989208080726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ATP2B4 [Title/Abstract] AND RBBP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ATP2B4(203596347)-RBBP4(33117515), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ATP2B4 | GO:0006874 | cellular calcium ion homeostasis | 19278978|25798335 |
Hgene | ATP2B4 | GO:0010629 | negative regulation of gene expression | 25147342 |
Hgene | ATP2B4 | GO:0010751 | negative regulation of nitric oxide mediated signal transduction | 19278978 |
Hgene | ATP2B4 | GO:0016525 | negative regulation of angiogenesis | 25147342 |
Hgene | ATP2B4 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19278978 |
Hgene | ATP2B4 | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 25147342 |
Hgene | ATP2B4 | GO:0045019 | negative regulation of nitric oxide biosynthetic process | 11591728|19278978 |
Hgene | ATP2B4 | GO:0051001 | negative regulation of nitric-oxide synthase activity | 11591728|17242280|19278978|19287093 |
Hgene | ATP2B4 | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade | 19287093|25147342 |
Hgene | ATP2B4 | GO:0071872 | cellular response to epinephrine stimulus | 19278978 |
Hgene | ATP2B4 | GO:0098736 | negative regulation of the force of heart contraction | 17242280 |
Hgene | ATP2B4 | GO:0140199 | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process | 17242280 |
Hgene | ATP2B4 | GO:1900082 | negative regulation of arginine catabolic process | 19278978 |
Hgene | ATP2B4 | GO:1901660 | calcium ion export | 25798335 |
Hgene | ATP2B4 | GO:1902548 | negative regulation of cellular response to vascular endothelial growth factor stimulus | 25147342 |
Hgene | ATP2B4 | GO:1903078 | positive regulation of protein localization to plasma membrane | 15955804 |
Hgene | ATP2B4 | GO:1903249 | negative regulation of citrulline biosynthetic process | 19278978 |
Hgene | ATP2B4 | GO:2000481 | positive regulation of cAMP-dependent protein kinase activity | 19278978 |
Tgene | RBBP4 | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
Tgene | RBBP4 | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
Tgene | RBBP4 | GO:0006338 | chromatin remodeling | 14609955 |
Tgene | RBBP4 | GO:0031497 | chromatin assembly | 8858152 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-HU-A4GH-01A | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
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Fusion Gene ORF analysis for ATP2B4-RBBP4 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000357681 | ENST00000373493 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-3CDS | ENST00000357681 | ENST00000414241 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-3CDS | ENST00000367218 | ENST00000373493 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-3CDS | ENST00000367218 | ENST00000414241 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-3CDS | ENST00000367219 | ENST00000373493 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-3CDS | ENST00000367219 | ENST00000414241 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-3CDS | ENST00000391954 | ENST00000373493 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-3CDS | ENST00000391954 | ENST00000414241 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-3UTR | ENST00000357681 | ENST00000524393 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-3UTR | ENST00000367218 | ENST00000524393 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-3UTR | ENST00000367219 | ENST00000524393 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-3UTR | ENST00000391954 | ENST00000524393 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-5UTR | ENST00000357681 | ENST00000373485 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-5UTR | ENST00000357681 | ENST00000458695 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-5UTR | ENST00000357681 | ENST00000544435 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-5UTR | ENST00000367218 | ENST00000373485 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-5UTR | ENST00000367218 | ENST00000458695 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-5UTR | ENST00000367218 | ENST00000544435 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-5UTR | ENST00000367219 | ENST00000373485 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-5UTR | ENST00000367219 | ENST00000458695 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-5UTR | ENST00000367219 | ENST00000544435 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-5UTR | ENST00000391954 | ENST00000373485 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-5UTR | ENST00000391954 | ENST00000458695 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
5UTR-5UTR | ENST00000391954 | ENST00000544435 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
intron-3CDS | ENST00000341360 | ENST00000373493 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
intron-3CDS | ENST00000341360 | ENST00000414241 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
intron-3CDS | ENST00000466407 | ENST00000373493 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
intron-3CDS | ENST00000466407 | ENST00000414241 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
intron-3UTR | ENST00000341360 | ENST00000524393 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
intron-3UTR | ENST00000466407 | ENST00000524393 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
intron-5UTR | ENST00000341360 | ENST00000373485 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
intron-5UTR | ENST00000341360 | ENST00000458695 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
intron-5UTR | ENST00000341360 | ENST00000544435 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
intron-5UTR | ENST00000466407 | ENST00000373485 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
intron-5UTR | ENST00000466407 | ENST00000458695 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
intron-5UTR | ENST00000466407 | ENST00000544435 | ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117515 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ATP2B4-RBBP4 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117514 | + | 0.0498626 | 0.9501374 |
ATP2B4 | chr1 | 203596347 | + | RBBP4 | chr1 | 33117514 | + | 0.0498626 | 0.9501374 |
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Fusion Protein Features for ATP2B4-RBBP4 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:203596347/:33117515) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ATP2B4-RBBP4 |
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Fusion Gene PPI Analysis for ATP2B4-RBBP4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ATP2B4-RBBP4 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ATP2B4-RBBP4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |