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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF165-ADAM10 (FusionGDB2 ID:HG494470TG102)

Fusion Gene Summary for RNF165-ADAM10

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF165-ADAM10
Fusion gene ID: hg494470tg102
HgeneTgene
Gene symbol

RNF165

ADAM10

Gene ID

494470

102

Gene namering finger protein 165ADAM metallopeptidase domain 10
SynonymsARKL2|Ark2C|RNF111L2AD10|AD18|CD156c|CDw156|HsT18717|MADM|RAK|kuz
Cytomap('RNF165')('ADAM10')

18q21.1

15q21.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF165disintegrin and metalloproteinase domain-containing protein 10a disintegrin and metalloprotease domain 10kuzbanian protein homologmammalian disintegrin-metalloprotease
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000269439, ENST00000587853, 
ENST00000588679, ENST00000590330, 
ENST00000543885, 
Fusion gene scores* DoF score5 X 3 X 5=7512 X 10 X 8=960
# samples 513
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/960*10)=-2.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF165 [Title/Abstract] AND ADAM10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF165(43914298)-ADAM10(58957396), # samples:1
Anticipated loss of major functional domain due to fusion event.RNF165-ADAM10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RNF165-ADAM10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RNF165-ADAM10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RNF165-ADAM10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RNF165-ADAM10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RNF165-ADAM10 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADAM10

GO:0006509

membrane protein ectodomain proteolysis

12714508|17557115|18355449|18419754|18676862|19114711

TgeneADAM10

GO:0007162

negative regulation of cell adhesion

12714508

TgeneADAM10

GO:0034612

response to tumor necrosis factor

11831872

TgeneADAM10

GO:0051089

constitutive protein ectodomain proteolysis

12714508


check buttonFusion gene breakpoints across RNF165 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ADAM10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-19-4065-02ARNF165chr18

43914298

+ADAM10chr15

58957396

-


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Fusion Gene ORF analysis for RNF165-ADAM10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000269439ENST00000558733RNF165chr18

43914298

+ADAM10chr15

58957396

-
5CDS-5UTRENST00000587853ENST00000558733RNF165chr18

43914298

+ADAM10chr15

58957396

-
5CDS-5UTRENST00000588679ENST00000558733RNF165chr18

43914298

+ADAM10chr15

58957396

-
5CDS-5UTRENST00000590330ENST00000558733RNF165chr18

43914298

+ADAM10chr15

58957396

-
5CDS-intronENST00000269439ENST00000396140RNF165chr18

43914298

+ADAM10chr15

58957396

-
5CDS-intronENST00000269439ENST00000402627RNF165chr18

43914298

+ADAM10chr15

58957396

-
5CDS-intronENST00000269439ENST00000561288RNF165chr18

43914298

+ADAM10chr15

58957396

-
5CDS-intronENST00000587853ENST00000396140RNF165chr18

43914298

+ADAM10chr15

58957396

-
5CDS-intronENST00000587853ENST00000402627RNF165chr18

43914298

+ADAM10chr15

58957396

-
5CDS-intronENST00000587853ENST00000561288RNF165chr18

43914298

+ADAM10chr15

58957396

-
5CDS-intronENST00000588679ENST00000396140RNF165chr18

43914298

+ADAM10chr15

58957396

-
5CDS-intronENST00000588679ENST00000402627RNF165chr18

43914298

+ADAM10chr15

58957396

-
5CDS-intronENST00000588679ENST00000561288RNF165chr18

43914298

+ADAM10chr15

58957396

-
5CDS-intronENST00000590330ENST00000396140RNF165chr18

43914298

+ADAM10chr15

58957396

-
5CDS-intronENST00000590330ENST00000402627RNF165chr18

43914298

+ADAM10chr15

58957396

-
5CDS-intronENST00000590330ENST00000561288RNF165chr18

43914298

+ADAM10chr15

58957396

-
5UTR-3CDSENST00000543885ENST00000260408RNF165chr18

43914298

+ADAM10chr15

58957396

-
5UTR-5UTRENST00000543885ENST00000558733RNF165chr18

43914298

+ADAM10chr15

58957396

-
5UTR-intronENST00000543885ENST00000396140RNF165chr18

43914298

+ADAM10chr15

58957396

-
5UTR-intronENST00000543885ENST00000402627RNF165chr18

43914298

+ADAM10chr15

58957396

-
5UTR-intronENST00000543885ENST00000561288RNF165chr18

43914298

+ADAM10chr15

58957396

-
Frame-shiftENST00000588679ENST00000260408RNF165chr18

43914298

+ADAM10chr15

58957396

-
In-frameENST00000269439ENST00000260408RNF165chr18

43914298

+ADAM10chr15

58957396

-
In-frameENST00000587853ENST00000260408RNF165chr18

43914298

+ADAM10chr15

58957396

-
In-frameENST00000590330ENST00000260408RNF165chr18

43914298

+ADAM10chr15

58957396

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000269439RNF165chr1843914298+ENST00000260408ADAM10chr1558957396-4218112511874607
ENST00000587853RNF165chr1843914298+ENST00000260408ADAM10chr1558957396-435725112013670
ENST00000590330RNF165chr1843914298+ENST00000260408ADAM10chr1558957396-441430872070687

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000269439ENST00000260408RNF165chr1843914298+ADAM10chr1558957396-0.0001026760.99989736
ENST00000587853ENST00000260408RNF165chr1843914298+ADAM10chr1558957396-0.0001034640.9998965
ENST00000590330ENST00000260408RNF165chr1843914298+ADAM10chr1558957396-0.0001078970.9998921

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Fusion Genomic Features for RNF165-ADAM10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for RNF165-ADAM10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:43914298/chr15:58957396)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADAM10chr18:43914298chr15:58957396ENST00000260408316555_673161749.0Compositional biasCys-rich
TgeneADAM10chr18:43914298chr15:58957396ENST00000260408316220_456161749.0DomainPeptidase M12B
TgeneADAM10chr18:43914298chr15:58957396ENST00000260408316457_551161749.0DomainDisintegrin
TgeneADAM10chr18:43914298chr15:58957396ENST00000260408316171_178161749.0MotifCysteine switch
TgeneADAM10chr18:43914298chr15:58957396ENST00000260408316708_715161749.0MotifSH3-binding
TgeneADAM10chr18:43914298chr15:58957396ENST00000260408316722_728161749.0MotifSH3-binding
TgeneADAM10chr18:43914298chr15:58957396ENST00000260408316694_748161749.0Topological domainCytoplasmic
TgeneADAM10chr18:43914298chr15:58957396ENST00000260408316673_693161749.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF165chr18:43914298chr15:58957396ENST00000269439+18266_26820347.0RegionUbiquitin binding
HgeneRNF165chr18:43914298chr15:58957396ENST00000269439+18309_31320347.0RegionUbiquitin binding
HgeneRNF165chr18:43914298chr15:58957396ENST00000543885+16266_2680155.0RegionUbiquitin binding
HgeneRNF165chr18:43914298chr15:58957396ENST00000543885+16309_3130155.0RegionUbiquitin binding
HgeneRNF165chr18:43914298chr15:58957396ENST00000269439+18294_33520347.0Zinc fingerRING-type%3B atypical
HgeneRNF165chr18:43914298chr15:58957396ENST00000543885+16294_3350155.0Zinc fingerRING-type%3B atypical
TgeneADAM10chr18:43914298chr15:58957396ENST0000026040831620_672161749.0Topological domainExtracellular


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Fusion Gene Sequence for RNF165-ADAM10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>74858_74858_1_RNF165-ADAM10_RNF165_chr18_43914298_ENST00000269439_ADAM10_chr15_58957396_ENST00000260408_length(transcript)=4218nt_BP=112nt
ACAAAGGGCCCGCGCGCAGCCGCCGCCGCCGCCGCCGCGCGAGGAGCCAGGATGGTCCTGGTCCACGTCGGCTATCTCGTGCTTCCAGTG
TTTGGCTCTGTGCGAAACAGAGACTATCCCCATAAATACGGTCCTCAGGGGGGCTGTGCAGATCATTCAGTATTTGAAAGAATGAGGAAA
TACCAGATGACTGGTGTAGAGGAAGTAACACAGATACCTCAAGAAGAACATGCTGCTAATGGTCCAGAACTTCTGAGGAAAAAACGTACA
ACTTCAGCTGAAAAAAATACTTGTCAGCTTTATATTCAGACTGATCATTTGTTCTTTAAATATTACGGAACACGAGAAGCTGTGATTGCC
CAGATATCCAGTCATGTTAAAGCGATTGATACAATTTACCAGACCACAGACTTCTCCGGAATCCGTAACATCAGTTTCATGGTGAAACGC
ATAAGAATCAATACAACTGCTGATGAGAAGGACCCTACAAATCCTTTCCGTTTCCCAAATATTGGTGTGGAGAAGTTTCTGGAATTGAAT
TCTGAGCAGAATCATGATGACTACTGTTTGGCCTATGTCTTCACAGACCGAGATTTTGATGATGGCGTACTTGGTCTGGCTTGGGTTGGA
GCACCTTCAGGAAGCTCTGGAGGAATATGTGAAAAAAGTAAACTCTATTCAGATGGTAAGAAGAAGTCCTTAAACACTGGAATTATTACT
GTTCAGAACTATGGGTCTCATGTACCTCCCAAAGTCTCTCACATTACTTTTGCTCACGAAGTTGGACATAACTTTGGATCCCCACATGAT
TCTGGAACAGAGTGCACACCAGGAGAATCTAAGAATTTGGGTCAAAAAGAAAATGGCAATTACATCATGTATGCAAGAGCAACATCTGGG
GACAAACTTAACAACAATAAATTCTCACTCTGTAGTATTAGAAATATAAGCCAAGTTCTTGAGAAGAAGAGAAACAACTGTTTTGTTGAA
TCTGGCCAACCTATTTGTGGAAATGGAATGGTAGAACAAGGTGAAGAATGTGATTGTGGCTATAGTGACCAGTGTAAAGATGAATGCTGC
TTCGATGCAAATCAACCAGAGGGAAGAAAATGCAAACTGAAACCTGGGAAACAGTGCAGTCCAAGTCAAGGTCCTTGTTGTACAGCACAG
TGTGCATTCAAGTCAAAGTCTGAGAAGTGTCGGGATGATTCAGACTGTGCAAGGGAAGGAATATGTAATGGCTTCACAGCTCTCTGCCCA
GCATCTGACCCTAAACCAAACTTCACAGACTGTAATAGGCATACACAAGTGTGCATTAATGGGCAATGTGCAGGTTCTATCTGTGAGAAA
TATGGCTTAGAGGAGTGTACGTGTGCCAGTTCTGATGGCAAAGATGATAAAGAATTATGCCATGTATGCTGTATGAAGAAAATGGACCCA
TCAACTTGTGCCAGTACAGGGTCTGTGCAGTGGAGTAGGCACTTCAGTGGTCGAACCATCACCCTGCAACCTGGATCCCCTTGCAACGAT
TTTAGAGGTTACTGTGATGTTTTCATGCGGTGCAGATTAGTAGATGCTGATGGTCCTCTAGCTAGGCTTAAAAAAGCAATTTTTAGTCCA
GAGCTCTATGAAAACATTGCTGAATGGATTGTGGCTCATTGGTGGGCAGTATTACTTATGGGAATTGCTCTGATCATGCTAATGGCTGGA
TTTATTAAGATATGCAGTGTTCATACTCCAAGTAGTAATCCAAAGTTGCCTCCTCCTAAACCACTTCCAGGCACTTTAAAGAGGAGGAGA
CCTCCACAGCCCATTCAGCAACCCCAGCGTCAGCGGCCCCGAGAGAGTTATCAAATGGGACACATGAGACGCTAACTGCAGCTTTTGCCT
TGGTTCTTCCTAGTGCCTACAATGGGAAAACTTCACTCCAAAGAGAAACCTATTAAGTCATCATCTCCAAACTAAACCCTCACAAGTAAC
AGTTGAAGAAAAAATGGCAAGAGATCATATCCTCAGACCAGGTGGAATTACTTAAATTTTAAAGCCTGAAAATTCCAATTTGGGGGTGGG
AGGTGGAAAAGGAACCCAATTTTCTTATGAACAGATATTTTTAACTTAATGGCACAAAGTCTTAGAATATTATTATGTGCCCCGTGTTCC
CTGTTCTTCGTTGCTGCATTTTCTTCACTTGCAGGCAAACTTGGCTCTCAATAAACTTTTACCACAAATTGAAATAAATATATTTTTTTC
AACTGCCAATCAAGGCTAGGAGGCTCGACCACCTCAACATTGGAGACATCACTTGCCAATGTACATACCTTGTTATATGCAGACATGTAT
TTCTTACGTACACTGTACTTCTGTGTGCAATTGTAAACAGAAATTGCAATATGGATGTTTCTTTGTATTATAAAATTTTTCCGCTCTTAA
TTAAAAATTACTGTTTAATTGACATACTCAGGATAACAGAGAATGGTGGTATTCAGTGGTCCAGGATTCTGTAATGCTTTACACAGGCAG
TTTTGAAATGAAAATCAATTTACCTTTCTGTTACGATGGAGTTGGTTTTGATACTCATTTTTTCTTTATCACATGGCTGCTACGGGCACA
AGTGACTATACTGAAGAACACAGTTAAGTGTTGTGCAAACTGGACATAGCAGCACATACTACTTCAGAGTTCATGATGTAGATGTCTGGT
TTCTGCTTACGTCTTTTAAACTTTCTAATTCAATTCCATTTTTCAATTAATAGGTGAAATTTTATTCATGCTTTGATAGAAATTATGTCA
ATGAAATGATTCTTTTTATTTGTAGCCTACTTATTTGTGTTTTTCATATATCTGAAATATGCTAATTATGTTTTCTGTCTGATATGGAAA
AGAAAAGCTGTGTCTTTATCAAAATATTTAAACGGTTTTTTCAGCATATCATCACTGATCATTGGTAACCACTAAAGATGAGTAATTTGC
TTAAGTAGTAGTTAAAATTGTAGATAGGCCTTCTGACATTTTTTTTCCTAAAATTTTTAACAGCATTGAAGGTGAAACAGCACAATGTCC
CATTCCAAATTTATTTTTGAAACAGATGTAAATAATTGGCATTTTAAAGAGAAAGCAAAAACATTTAATGTATTAACAGGCTTATTGCTA
TGCAGGAAATAGAAGGGGCATTACAAAAATTGAAGCTTGTGACATATTTATTGCTTCTGTTTTCCAACTACATCACTTCAACTAGAAGTA
AAGCTATGATTTTCCTGACTTCACATAGGAGGCAAATTTAGAGAAAGTTGTAAAGATTTCTATGTTTTGGGTTTTTTTTTTTCCTTTTTT
TTTTTAAGAGTATAAGGTTTACACAATCATTCTCATAATGTGACGCAAGCCAGCAAGGCCAAAAATGCTAGAGAAAATAACGGGATCTCT
TCCTTGTAAACTTGTACAGTATGTGGTGACTTTTTCAAAATACAGCTTTTTGTACATGATTTAGAGACAAATTTTGTACATGAAACCCCA
GATAGACTATAAATAATTCTAAACAAACAAGTAGGTAGATATGTATGTAATTGCTTTTAAATCATTTAAATGCCTTTGTTTTTGGACTGT
GCAAAGGTTGGAAGTGGGTTTGCATTTCTAAAATGGTGACTTTTATTCTGCAAGAGTTCTTAGTAACTTCTTGAGTGTGGTAGACTTTGG
AACATGTAAATTTTTTGCTTGTAATGTTATCCTGTGGTAGGATTTTGGCAGGTACACACACTGCCCTATTTTATTTTGAGTCTAAGTTAA
ATGTTTTCTGAAAAGAGATACATGCACTGAACTCTTTCCACTGCGAATCAAGATGTGGTAATATAAAAGGATCAAGACAAATGAGATCTA
ATACTACTGTCAGTTTTAATGTCCACTGTGTTTTATACAGTATCTTTTTTTGTTCACTTTGGAAATTTTTACTAAAAATTGCAAAAAATA
AAGTATTGTGCAAAGATGTAAGGTTTTTTGAAACTTGAAATGCATTAATAAATAGACGATTAAATCAACTTGAAGGTTCTATACTCTTTG
AACTCTGAGAACTATCACAAGAAGCTTCCCACAAGGCAGTGTTTTCTTACAGTTGTCTCTTCCTACAAAAGTATAGATTATCTTTATTCT

>74858_74858_1_RNF165-ADAM10_RNF165_chr18_43914298_ENST00000269439_ADAM10_chr15_58957396_ENST00000260408_length(amino acids)=607AA_BP=20
MVLVHVGYLVLPVFGSVRNRDYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHL
FFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDR
DFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKE
NGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGK
QCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDK
ELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAV

--------------------------------------------------------------
>74858_74858_2_RNF165-ADAM10_RNF165_chr18_43914298_ENST00000587853_ADAM10_chr15_58957396_ENST00000260408_length(transcript)=4357nt_BP=251nt
GCTGTCCCCCGCGGTTCCGGCGAGGCCGCGCCGCGCTGCGCTCCGCTCCCATTGGCTGCGCGCGCCTTTGTGTGGCGGCAGCTGCGGCCC
CAGCGCCTTTGAATGTCGAGAGGGGCCGGGAAGGGAGCCTTTCCATGGGCCATCTGGCCCGCGCGCAGCCGCCGCCGCCGCCGCCGCGCG
AGGAGCCAGGATGGTCCTGGTCCACGTCGGCTATCTCGTGCTTCCAGTGTTTGGCTCTGTGCGAAACAGAGACTATCCCCATAAATACGG
TCCTCAGGGGGGCTGTGCAGATCATTCAGTATTTGAAAGAATGAGGAAATACCAGATGACTGGTGTAGAGGAAGTAACACAGATACCTCA
AGAAGAACATGCTGCTAATGGTCCAGAACTTCTGAGGAAAAAACGTACAACTTCAGCTGAAAAAAATACTTGTCAGCTTTATATTCAGAC
TGATCATTTGTTCTTTAAATATTACGGAACACGAGAAGCTGTGATTGCCCAGATATCCAGTCATGTTAAAGCGATTGATACAATTTACCA
GACCACAGACTTCTCCGGAATCCGTAACATCAGTTTCATGGTGAAACGCATAAGAATCAATACAACTGCTGATGAGAAGGACCCTACAAA
TCCTTTCCGTTTCCCAAATATTGGTGTGGAGAAGTTTCTGGAATTGAATTCTGAGCAGAATCATGATGACTACTGTTTGGCCTATGTCTT
CACAGACCGAGATTTTGATGATGGCGTACTTGGTCTGGCTTGGGTTGGAGCACCTTCAGGAAGCTCTGGAGGAATATGTGAAAAAAGTAA
ACTCTATTCAGATGGTAAGAAGAAGTCCTTAAACACTGGAATTATTACTGTTCAGAACTATGGGTCTCATGTACCTCCCAAAGTCTCTCA
CATTACTTTTGCTCACGAAGTTGGACATAACTTTGGATCCCCACATGATTCTGGAACAGAGTGCACACCAGGAGAATCTAAGAATTTGGG
TCAAAAAGAAAATGGCAATTACATCATGTATGCAAGAGCAACATCTGGGGACAAACTTAACAACAATAAATTCTCACTCTGTAGTATTAG
AAATATAAGCCAAGTTCTTGAGAAGAAGAGAAACAACTGTTTTGTTGAATCTGGCCAACCTATTTGTGGAAATGGAATGGTAGAACAAGG
TGAAGAATGTGATTGTGGCTATAGTGACCAGTGTAAAGATGAATGCTGCTTCGATGCAAATCAACCAGAGGGAAGAAAATGCAAACTGAA
ACCTGGGAAACAGTGCAGTCCAAGTCAAGGTCCTTGTTGTACAGCACAGTGTGCATTCAAGTCAAAGTCTGAGAAGTGTCGGGATGATTC
AGACTGTGCAAGGGAAGGAATATGTAATGGCTTCACAGCTCTCTGCCCAGCATCTGACCCTAAACCAAACTTCACAGACTGTAATAGGCA
TACACAAGTGTGCATTAATGGGCAATGTGCAGGTTCTATCTGTGAGAAATATGGCTTAGAGGAGTGTACGTGTGCCAGTTCTGATGGCAA
AGATGATAAAGAATTATGCCATGTATGCTGTATGAAGAAAATGGACCCATCAACTTGTGCCAGTACAGGGTCTGTGCAGTGGAGTAGGCA
CTTCAGTGGTCGAACCATCACCCTGCAACCTGGATCCCCTTGCAACGATTTTAGAGGTTACTGTGATGTTTTCATGCGGTGCAGATTAGT
AGATGCTGATGGTCCTCTAGCTAGGCTTAAAAAAGCAATTTTTAGTCCAGAGCTCTATGAAAACATTGCTGAATGGATTGTGGCTCATTG
GTGGGCAGTATTACTTATGGGAATTGCTCTGATCATGCTAATGGCTGGATTTATTAAGATATGCAGTGTTCATACTCCAAGTAGTAATCC
AAAGTTGCCTCCTCCTAAACCACTTCCAGGCACTTTAAAGAGGAGGAGACCTCCACAGCCCATTCAGCAACCCCAGCGTCAGCGGCCCCG
AGAGAGTTATCAAATGGGACACATGAGACGCTAACTGCAGCTTTTGCCTTGGTTCTTCCTAGTGCCTACAATGGGAAAACTTCACTCCAA
AGAGAAACCTATTAAGTCATCATCTCCAAACTAAACCCTCACAAGTAACAGTTGAAGAAAAAATGGCAAGAGATCATATCCTCAGACCAG
GTGGAATTACTTAAATTTTAAAGCCTGAAAATTCCAATTTGGGGGTGGGAGGTGGAAAAGGAACCCAATTTTCTTATGAACAGATATTTT
TAACTTAATGGCACAAAGTCTTAGAATATTATTATGTGCCCCGTGTTCCCTGTTCTTCGTTGCTGCATTTTCTTCACTTGCAGGCAAACT
TGGCTCTCAATAAACTTTTACCACAAATTGAAATAAATATATTTTTTTCAACTGCCAATCAAGGCTAGGAGGCTCGACCACCTCAACATT
GGAGACATCACTTGCCAATGTACATACCTTGTTATATGCAGACATGTATTTCTTACGTACACTGTACTTCTGTGTGCAATTGTAAACAGA
AATTGCAATATGGATGTTTCTTTGTATTATAAAATTTTTCCGCTCTTAATTAAAAATTACTGTTTAATTGACATACTCAGGATAACAGAG
AATGGTGGTATTCAGTGGTCCAGGATTCTGTAATGCTTTACACAGGCAGTTTTGAAATGAAAATCAATTTACCTTTCTGTTACGATGGAG
TTGGTTTTGATACTCATTTTTTCTTTATCACATGGCTGCTACGGGCACAAGTGACTATACTGAAGAACACAGTTAAGTGTTGTGCAAACT
GGACATAGCAGCACATACTACTTCAGAGTTCATGATGTAGATGTCTGGTTTCTGCTTACGTCTTTTAAACTTTCTAATTCAATTCCATTT
TTCAATTAATAGGTGAAATTTTATTCATGCTTTGATAGAAATTATGTCAATGAAATGATTCTTTTTATTTGTAGCCTACTTATTTGTGTT
TTTCATATATCTGAAATATGCTAATTATGTTTTCTGTCTGATATGGAAAAGAAAAGCTGTGTCTTTATCAAAATATTTAAACGGTTTTTT
CAGCATATCATCACTGATCATTGGTAACCACTAAAGATGAGTAATTTGCTTAAGTAGTAGTTAAAATTGTAGATAGGCCTTCTGACATTT
TTTTTCCTAAAATTTTTAACAGCATTGAAGGTGAAACAGCACAATGTCCCATTCCAAATTTATTTTTGAAACAGATGTAAATAATTGGCA
TTTTAAAGAGAAAGCAAAAACATTTAATGTATTAACAGGCTTATTGCTATGCAGGAAATAGAAGGGGCATTACAAAAATTGAAGCTTGTG
ACATATTTATTGCTTCTGTTTTCCAACTACATCACTTCAACTAGAAGTAAAGCTATGATTTTCCTGACTTCACATAGGAGGCAAATTTAG
AGAAAGTTGTAAAGATTTCTATGTTTTGGGTTTTTTTTTTTCCTTTTTTTTTTTAAGAGTATAAGGTTTACACAATCATTCTCATAATGT
GACGCAAGCCAGCAAGGCCAAAAATGCTAGAGAAAATAACGGGATCTCTTCCTTGTAAACTTGTACAGTATGTGGTGACTTTTTCAAAAT
ACAGCTTTTTGTACATGATTTAGAGACAAATTTTGTACATGAAACCCCAGATAGACTATAAATAATTCTAAACAAACAAGTAGGTAGATA
TGTATGTAATTGCTTTTAAATCATTTAAATGCCTTTGTTTTTGGACTGTGCAAAGGTTGGAAGTGGGTTTGCATTTCTAAAATGGTGACT
TTTATTCTGCAAGAGTTCTTAGTAACTTCTTGAGTGTGGTAGACTTTGGAACATGTAAATTTTTTGCTTGTAATGTTATCCTGTGGTAGG
ATTTTGGCAGGTACACACACTGCCCTATTTTATTTTGAGTCTAAGTTAAATGTTTTCTGAAAAGAGATACATGCACTGAACTCTTTCCAC
TGCGAATCAAGATGTGGTAATATAAAAGGATCAAGACAAATGAGATCTAATACTACTGTCAGTTTTAATGTCCACTGTGTTTTATACAGT
ATCTTTTTTTGTTCACTTTGGAAATTTTTACTAAAAATTGCAAAAAATAAAGTATTGTGCAAAGATGTAAGGTTTTTTGAAACTTGAAAT
GCATTAATAAATAGACGATTAAATCAACTTGAAGGTTCTATACTCTTTGAACTCTGAGAACTATCACAAGAAGCTTCCCACAAGGCAGTG
TTTTCTTACAGTTGTCTCTTCCTACAAAAGTATAGATTATCTTTATTCTTAATACTTTGGAATCCATGTAGAAAATTTCCAGTTAGATAC

>74858_74858_2_RNF165-ADAM10_RNF165_chr18_43914298_ENST00000587853_ADAM10_chr15_58957396_ENST00000260408_length(amino acids)=670AA_BP=83
LSPAVPARPRRAALRSHWLRAPLCGGSCGPSAFECREGPGREPFHGPSGPRAAAAAAAARGARMVLVHVGYLVLPVFGSVRNRDYPHKYG
PQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQ
TTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSK
LYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIR
NISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDS
DCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRH
FSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNP

--------------------------------------------------------------
>74858_74858_3_RNF165-ADAM10_RNF165_chr18_43914298_ENST00000590330_ADAM10_chr15_58957396_ENST00000260408_length(transcript)=4414nt_BP=308nt
CGCGCCTTTGTGTGGCGGCAGCTGCGGCCCCAGCGCCTTTGAATGTCGAGAGGGGCCGGGAAGGGAGCCTTTCCATGGGCCATCTGTCTC
CCCGCCAGCCGCCGCCCCACCGCCGCCCGCGCCCCGCGCTCCGCCTCCCGCCCCGGCGGCTCCCGCAGCCCCGCCGCCGCCCGCGCCCGC
GCCCCGGAGCCGCGCCACAAAGGGCCCGCGCGCAGCCGCCGCCGCCGCCGCCGCGCGAGGAGCCAGGATGGTCCTGGTCCACGTCGGCTA
TCTCGTGCTTCCAGTGTTTGGCTCTGTGCGAAACAGAGACTATCCCCATAAATACGGTCCTCAGGGGGGCTGTGCAGATCATTCAGTATT
TGAAAGAATGAGGAAATACCAGATGACTGGTGTAGAGGAAGTAACACAGATACCTCAAGAAGAACATGCTGCTAATGGTCCAGAACTTCT
GAGGAAAAAACGTACAACTTCAGCTGAAAAAAATACTTGTCAGCTTTATATTCAGACTGATCATTTGTTCTTTAAATATTACGGAACACG
AGAAGCTGTGATTGCCCAGATATCCAGTCATGTTAAAGCGATTGATACAATTTACCAGACCACAGACTTCTCCGGAATCCGTAACATCAG
TTTCATGGTGAAACGCATAAGAATCAATACAACTGCTGATGAGAAGGACCCTACAAATCCTTTCCGTTTCCCAAATATTGGTGTGGAGAA
GTTTCTGGAATTGAATTCTGAGCAGAATCATGATGACTACTGTTTGGCCTATGTCTTCACAGACCGAGATTTTGATGATGGCGTACTTGG
TCTGGCTTGGGTTGGAGCACCTTCAGGAAGCTCTGGAGGAATATGTGAAAAAAGTAAACTCTATTCAGATGGTAAGAAGAAGTCCTTAAA
CACTGGAATTATTACTGTTCAGAACTATGGGTCTCATGTACCTCCCAAAGTCTCTCACATTACTTTTGCTCACGAAGTTGGACATAACTT
TGGATCCCCACATGATTCTGGAACAGAGTGCACACCAGGAGAATCTAAGAATTTGGGTCAAAAAGAAAATGGCAATTACATCATGTATGC
AAGAGCAACATCTGGGGACAAACTTAACAACAATAAATTCTCACTCTGTAGTATTAGAAATATAAGCCAAGTTCTTGAGAAGAAGAGAAA
CAACTGTTTTGTTGAATCTGGCCAACCTATTTGTGGAAATGGAATGGTAGAACAAGGTGAAGAATGTGATTGTGGCTATAGTGACCAGTG
TAAAGATGAATGCTGCTTCGATGCAAATCAACCAGAGGGAAGAAAATGCAAACTGAAACCTGGGAAACAGTGCAGTCCAAGTCAAGGTCC
TTGTTGTACAGCACAGTGTGCATTCAAGTCAAAGTCTGAGAAGTGTCGGGATGATTCAGACTGTGCAAGGGAAGGAATATGTAATGGCTT
CACAGCTCTCTGCCCAGCATCTGACCCTAAACCAAACTTCACAGACTGTAATAGGCATACACAAGTGTGCATTAATGGGCAATGTGCAGG
TTCTATCTGTGAGAAATATGGCTTAGAGGAGTGTACGTGTGCCAGTTCTGATGGCAAAGATGATAAAGAATTATGCCATGTATGCTGTAT
GAAGAAAATGGACCCATCAACTTGTGCCAGTACAGGGTCTGTGCAGTGGAGTAGGCACTTCAGTGGTCGAACCATCACCCTGCAACCTGG
ATCCCCTTGCAACGATTTTAGAGGTTACTGTGATGTTTTCATGCGGTGCAGATTAGTAGATGCTGATGGTCCTCTAGCTAGGCTTAAAAA
AGCAATTTTTAGTCCAGAGCTCTATGAAAACATTGCTGAATGGATTGTGGCTCATTGGTGGGCAGTATTACTTATGGGAATTGCTCTGAT
CATGCTAATGGCTGGATTTATTAAGATATGCAGTGTTCATACTCCAAGTAGTAATCCAAAGTTGCCTCCTCCTAAACCACTTCCAGGCAC
TTTAAAGAGGAGGAGACCTCCACAGCCCATTCAGCAACCCCAGCGTCAGCGGCCCCGAGAGAGTTATCAAATGGGACACATGAGACGCTA
ACTGCAGCTTTTGCCTTGGTTCTTCCTAGTGCCTACAATGGGAAAACTTCACTCCAAAGAGAAACCTATTAAGTCATCATCTCCAAACTA
AACCCTCACAAGTAACAGTTGAAGAAAAAATGGCAAGAGATCATATCCTCAGACCAGGTGGAATTACTTAAATTTTAAAGCCTGAAAATT
CCAATTTGGGGGTGGGAGGTGGAAAAGGAACCCAATTTTCTTATGAACAGATATTTTTAACTTAATGGCACAAAGTCTTAGAATATTATT
ATGTGCCCCGTGTTCCCTGTTCTTCGTTGCTGCATTTTCTTCACTTGCAGGCAAACTTGGCTCTCAATAAACTTTTACCACAAATTGAAA
TAAATATATTTTTTTCAACTGCCAATCAAGGCTAGGAGGCTCGACCACCTCAACATTGGAGACATCACTTGCCAATGTACATACCTTGTT
ATATGCAGACATGTATTTCTTACGTACACTGTACTTCTGTGTGCAATTGTAAACAGAAATTGCAATATGGATGTTTCTTTGTATTATAAA
ATTTTTCCGCTCTTAATTAAAAATTACTGTTTAATTGACATACTCAGGATAACAGAGAATGGTGGTATTCAGTGGTCCAGGATTCTGTAA
TGCTTTACACAGGCAGTTTTGAAATGAAAATCAATTTACCTTTCTGTTACGATGGAGTTGGTTTTGATACTCATTTTTTCTTTATCACAT
GGCTGCTACGGGCACAAGTGACTATACTGAAGAACACAGTTAAGTGTTGTGCAAACTGGACATAGCAGCACATACTACTTCAGAGTTCAT
GATGTAGATGTCTGGTTTCTGCTTACGTCTTTTAAACTTTCTAATTCAATTCCATTTTTCAATTAATAGGTGAAATTTTATTCATGCTTT
GATAGAAATTATGTCAATGAAATGATTCTTTTTATTTGTAGCCTACTTATTTGTGTTTTTCATATATCTGAAATATGCTAATTATGTTTT
CTGTCTGATATGGAAAAGAAAAGCTGTGTCTTTATCAAAATATTTAAACGGTTTTTTCAGCATATCATCACTGATCATTGGTAACCACTA
AAGATGAGTAATTTGCTTAAGTAGTAGTTAAAATTGTAGATAGGCCTTCTGACATTTTTTTTCCTAAAATTTTTAACAGCATTGAAGGTG
AAACAGCACAATGTCCCATTCCAAATTTATTTTTGAAACAGATGTAAATAATTGGCATTTTAAAGAGAAAGCAAAAACATTTAATGTATT
AACAGGCTTATTGCTATGCAGGAAATAGAAGGGGCATTACAAAAATTGAAGCTTGTGACATATTTATTGCTTCTGTTTTCCAACTACATC
ACTTCAACTAGAAGTAAAGCTATGATTTTCCTGACTTCACATAGGAGGCAAATTTAGAGAAAGTTGTAAAGATTTCTATGTTTTGGGTTT
TTTTTTTTCCTTTTTTTTTTTAAGAGTATAAGGTTTACACAATCATTCTCATAATGTGACGCAAGCCAGCAAGGCCAAAAATGCTAGAGA
AAATAACGGGATCTCTTCCTTGTAAACTTGTACAGTATGTGGTGACTTTTTCAAAATACAGCTTTTTGTACATGATTTAGAGACAAATTT
TGTACATGAAACCCCAGATAGACTATAAATAATTCTAAACAAACAAGTAGGTAGATATGTATGTAATTGCTTTTAAATCATTTAAATGCC
TTTGTTTTTGGACTGTGCAAAGGTTGGAAGTGGGTTTGCATTTCTAAAATGGTGACTTTTATTCTGCAAGAGTTCTTAGTAACTTCTTGA
GTGTGGTAGACTTTGGAACATGTAAATTTTTTGCTTGTAATGTTATCCTGTGGTAGGATTTTGGCAGGTACACACACTGCCCTATTTTAT
TTTGAGTCTAAGTTAAATGTTTTCTGAAAAGAGATACATGCACTGAACTCTTTCCACTGCGAATCAAGATGTGGTAATATAAAAGGATCA
AGACAAATGAGATCTAATACTACTGTCAGTTTTAATGTCCACTGTGTTTTATACAGTATCTTTTTTTGTTCACTTTGGAAATTTTTACTA
AAAATTGCAAAAAATAAAGTATTGTGCAAAGATGTAAGGTTTTTTGAAACTTGAAATGCATTAATAAATAGACGATTAAATCAACTTGAA
GGTTCTATACTCTTTGAACTCTGAGAACTATCACAAGAAGCTTCCCACAAGGCAGTGTTTTCTTACAGTTGTCTCTTCCTACAAAAGTAT
AGATTATCTTTATTCTTAATACTTTGGAATCCATGTAGAAAATTTCCAGTTAGATACTCTGCGTACACACAATAAACCTTTTTAAAACAC

>74858_74858_3_RNF165-ADAM10_RNF165_chr18_43914298_ENST00000590330_ADAM10_chr15_58957396_ENST00000260408_length(amino acids)=687AA_BP=45
MCGGSCGPSAFECREGPGREPFHGPSVSPPAAAPPPPAPRAPPPAPAAPAAPPPPAPAPRSRATKGPRAAAAAAAARGARMVLVHVGYLV
LPVFGSVRNRDYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREA
VIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLA
WVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARA
TSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCC
TAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKK
MDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIML

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RNF165-ADAM10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneADAM10chr18:43914298chr15:58957396ENST00000260408316734_748161.33333333333334749.0AP2A1%2C AP2A2 and AP2M1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF165-ADAM10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF165-ADAM10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC3810041ALZHEIMER DISEASE 182CTD_human;UNIPROT
TgeneC0002395Alzheimer's Disease1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0011265Presenile dementia1CTD_human
TgeneC0276496Familial Alzheimer Disease (FAD)1CTD_human
TgeneC0406811Reticulate acropigmentation of Kitamura1CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0494463Alzheimer Disease, Late Onset1CTD_human
TgeneC0546126Acute Confusional Senile Dementia1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0750900Alzheimer's Disease, Focal Onset1CTD_human
TgeneC0750901Alzheimer Disease, Early Onset1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human