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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ATP4A-FKBP4 (FusionGDB2 ID:HG495TG2288) |
Fusion Gene Summary for ATP4A-FKBP4 |
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Fusion gene information | Fusion gene name: ATP4A-FKBP4 | Fusion gene ID: hg495tg2288 | Hgene | Tgene | Gene symbol | ATP4A | FKBP4 | Gene ID | 495 | 2288 |
Gene name | ATPase H+/K+ transporting subunit alpha | FKBP prolyl isomerase 4 | |
Synonyms | ATP6A | FKBP51|FKBP52|FKBP59|HBI|Hsp56|PPIase|p52 | |
Cytomap | ('ATP4A')('FKBP4') 19q13.12 | 12p13.33 | |
Type of gene | protein-coding | protein-coding | |
Description | potassium-transporting ATPase alpha chain 1ATPase H+/K+ transporting alpha subunitATPase, H+/K+ exchanging, alpha polypeptideATPase, H+/K+ transporting, alpha polypeptideepididymis secretory sperm binding proteingastric H+/K+ ATPase alpha subunitgas | peptidyl-prolyl cis-trans isomerase FKBP4FK506 binding protein 4, 59kDaHSP binding immunophilinT-cell FK506-binding protein, 59kDpeptidylprolyl cis-trans isomeraserotamase | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P20648 | . | |
Ensembl transtripts involved in fusion gene | ENST00000262623, | ||
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: ATP4A [Title/Abstract] AND FKBP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ATP4A(36049894)-FKBP4(2908253), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | ATP4A-FKBP4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP4A-FKBP4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP4A-FKBP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ATP4A-FKBP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FKBP4 | GO:0061077 | chaperone-mediated protein folding | 11350175 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | ESCA | TCGA-JY-A939 | ATP4A | chr19 | 36049894 | - | FKBP4 | chr12 | 2908253 | + |
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Fusion Gene ORF analysis for ATP4A-FKBP4 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000262623 | ENST00000540260 | ATP4A | chr19 | 36049894 | - | FKBP4 | chr12 | 2908253 | + |
In-frame | ENST00000262623 | ENST00000001008 | ATP4A | chr19 | 36049894 | - | FKBP4 | chr12 | 2908253 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000262623 | ATP4A | chr19 | 36049894 | - | ENST00000001008 | FKBP4 | chr12 | 2908253 | + | 2850 | 1284 | 29 | 2149 | 706 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000262623 | ENST00000001008 | ATP4A | chr19 | 36049894 | - | FKBP4 | chr12 | 2908253 | + | 0.003975601 | 0.99602437 |
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Fusion Genomic Features for ATP4A-FKBP4 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ATP4A | chr19 | 36049894 | - | FKBP4 | chr12 | 2908253 | + | 0.000816054 | 0.99918395 |
ATP4A | chr19 | 36049894 | - | FKBP4 | chr12 | 2908253 | + | 0.000816054 | 0.99918395 |
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Fusion Protein Features for ATP4A-FKBP4 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:36049894/chr12:2908253) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ATP4A | . |
FUNCTION: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 120_142 | 418 | 1036.0 | Topological domain | Lumenal |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 164_299 | 418 | 1036.0 | Topological domain | Cytoplasmic |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 1_98 | 418 | 1036.0 | Topological domain | Cytoplasmic |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 320_331 | 418 | 1036.0 | Topological domain | Lumenal |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 143_163 | 418 | 1036.0 | Transmembrane | Helical |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 300_319 | 418 | 1036.0 | Transmembrane | Helical |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 332_349 | 418 | 1036.0 | Transmembrane | Helical |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 99_119 | 418 | 1036.0 | Transmembrane | Helical |
Tgene | FKBP4 | chr19:36049894 | chr12:2908253 | ENST00000001008 | 3 | 10 | 270_303 | 171 | 460.0 | Repeat | Note=TPR 1 | |
Tgene | FKBP4 | chr19:36049894 | chr12:2908253 | ENST00000001008 | 3 | 10 | 319_352 | 171 | 460.0 | Repeat | Note=TPR 2 | |
Tgene | FKBP4 | chr19:36049894 | chr12:2908253 | ENST00000001008 | 3 | 10 | 353_386 | 171 | 460.0 | Repeat | Note=TPR 3 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 1019_1035 | 418 | 1036.0 | Topological domain | Cytoplasmic |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 350_783 | 418 | 1036.0 | Topological domain | Cytoplasmic |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 804_813 | 418 | 1036.0 | Topological domain | Lumenal |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 835_854 | 418 | 1036.0 | Topological domain | Cytoplasmic |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 878_929 | 418 | 1036.0 | Topological domain | Lumenal |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 950_963 | 418 | 1036.0 | Topological domain | Cytoplasmic |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 983_997 | 418 | 1036.0 | Topological domain | Lumenal |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 784_803 | 418 | 1036.0 | Transmembrane | Helical |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 814_834 | 418 | 1036.0 | Transmembrane | Helical |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 855_877 | 418 | 1036.0 | Transmembrane | Helical |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 930_949 | 418 | 1036.0 | Transmembrane | Helical |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 964_982 | 418 | 1036.0 | Transmembrane | Helical |
Hgene | ATP4A | chr19:36049894 | chr12:2908253 | ENST00000262623 | - | 8 | 22 | 998_1018 | 418 | 1036.0 | Transmembrane | Helical |
Tgene | FKBP4 | chr19:36049894 | chr12:2908253 | ENST00000001008 | 3 | 10 | 167_253 | 171 | 460.0 | Domain | PPIase FKBP-type 2 | |
Tgene | FKBP4 | chr19:36049894 | chr12:2908253 | ENST00000001008 | 3 | 10 | 50_138 | 171 | 460.0 | Domain | PPIase FKBP-type 1 |
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Fusion Gene Sequence for ATP4A-FKBP4 |
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>7909_7909_1_ATP4A-FKBP4_ATP4A_chr19_36049894_ENST00000262623_FKBP4_chr12_2908253_ENST00000001008_length(transcript)=2850nt_BP=1284nt GTTGGGTGGGAGCACAGGCACCGGGCACCATGGGGAAGGCCGAGAACTATGAGCTCTACTCGGTGGAGCTGGGTCCTGGCCCTGGCGGGG ACATGGCTGCCAAGATGAGCAAGAAGAAGAAGGCGGGTGGCGGGGGTGGCAAGAGGAAGGAGAAGCTGGAGAACATGAAGAAGGAGATGG AGATTAACGACCACCAGCTGTCAGTGGCGGAGCTGGAACAGAAATACCAGACCAGTGCCACCAAGGGCCTCTCTGCGAGCCTGGCTGCTG AGCTGCTGCTGCGGGATGGGCCCAACGCACTGCGGCCACCACGGGGCACCCCAGAGTACGTCAAGTTCGCGAGGCAGCTGGCCGGGGGCC TGCAGTGCCTCATGTGGGTTGCCGCCGCCATCTGCCTCATCGCCTTTGCCATCCAGGCTAGTGAGGGGGACCTCACCACCGACGACAATC TGTACCTGGCAATCGCTCTCATTGCTGTGGTTGTCGTCACCGGCTGCTTTGGCTACTACCAGGAATTCAAGAGCACCAACATCATCGCCA GCTTTAAGAACCTTGTGCCACAGCAAGCCACTGTCATCCGCGATGGAGACAAATTCCAGATCAACGCTGACCAACTGGTGGTGGGCGACC TGGTGGAGATGAAAGGTGGGGACAGAGTGCCCGCCGACATCCGCATCCTGGCGGCCCAGGGCTGCAAGGTGGACAACTCCTCGCTGACAG GGGAGTCTGAGCCACAGACCCGCTCACCCGAGTGCACGCACGAGAGCCCTCTGGAGACCCGCAACATCGCCTTCTTCTCCACCATGTGCC TTGAGGGCACCGTGCAGGGCCTGGTGGTGAACACGGGCGACCGCACCATCATTGGGCGCATCGCATCGCTGGCGTCGGGGGTGGAAAACG AGAAGACACCCATCGCTATCGAGATCGAGCATTTTGTGGACATCATCGCGGGCCTGGCCATTCTCTTCGGTGCCACATTTTTTATTGTGG CCATGTGCATTGGCTACACCTTCCTGCGGGCCATGGTCTTCTTCATGGCCATCGTGGTGGCCTATGTGCCTGAGGGGCTGCTGGCCACTG TCACAGTCTGCCTGTCCCTGACAGCCAAGCGCCTGGCCAGTAAGAACTGCGTGGTCAAGAACCTGGAGGCGGTGGAGACATTGGGCTCCA CTTCGGTGATCTGCTCGGACAAGACAGGGACTCTCACTCAGAACCGCATGACTGTGTCCCATCTGTGGTTTGACAACCACATCCACACAG CTGACACCACGGAAGACCAGTCAGTTGCACTGGAAGGGTACTACAAGGACAAGCTCTTTGACCAGCGGGAGCTCCGCTTTGAGATTGGCG AGGGGGAGAACCTGGATCTGCCTTATGGTCTGGAGAGGGCCATTCAGCGCATGGAGAAAGGAGAACATTCCATCGTGTACCTCAAGCCCA GCTATGCTTTTGGCAGTGTTGGGAAGGAAAAGTTCCAAATCCCACCAAATGCTGAGCTGAAATATGAATTACACCTCAAGAGTTTTGAAA AGGCCAAGGAGTCTTGGGAGATGAATTCAGAAGAGAAGCTGGAACAGAGCACCATAGTGAAAGAGCGGGGCACTGTGTACTTCAAGGAAG GTAAATACAAGCAAGCTTTACTACAGTATAAGAAGATCGTGTCTTGGCTGGAATATGAGTCTAGTTTTTCCAATGAGGAAGCACAGAAAG CACAGGCCCTTCGACTGGCCTCTCACCTCAACCTGGCCATGTGTCATCTGAAACTACAGGCCTTCTCTGCTGCCATTGAAAGCTGTAACA AGGCCCTAGAACTGGACAGCAACAACGAGAAGGGCCTCTTCCGCCGGGGAGAGGCCCACCTGGCCGTGAATGACTTTGAACTGGCACGGG CTGATTTCCAGAAGGTCCTGCAGCTCTACCCCAACAACAAAGCCGCCAAGACCCAGCTGGCTGTGTGCCAGCAGCGGATCCGAAGGCAGC TTGCCCGGGAGAAGAAGCTCTATGCCAATATGTTTGAGAGGCTGGCTGAGGAGGAGAACAAGGCCAAGGCAGAGGCTTCCTCAGGAGACC ATCCCACTGACACAGAGATGAAGGAGGAGCAGAAGAGCAACACGGCAGGGAGCCAGTCTCAGGTGGAGACAGAAGCATAGCCCCTCTCCA CCAGCCCTACTCCTGCGGCTGCCTGCCCCCCAGTCTCCCCACTCCACCCTGTTAGTTTTGTAAAAACTGAAGAATTTTGAGTGAATTAGA CCTTTATTTTTCTATCTGGTTGGATGGTGGCTTTAGGGGAAGGGGGAAAGGTGTAGGCTGGGGGATTGAGGTGGGGAATCATTTTAGCTG GTGTCAGCCCCTCTTCCCTTCCTCCATTGCACATGAACATATGTCCATCCATATATATTCATCAGAATGTTAATTTATTTTGCTCCCTCT GTTAGGTCCATTTTCTAAGGGTAGAAGAGGCAAGTGGTAGGGATGAGGTCTGATAAGAACCCAGGGTGGAGAGGGAGACTCCTGGGCAGC CGTTTTCCTCATCCTTTCCCTCTCCCAGTCCATTTCCAAATGTGGCCTCCATGTGGGTGCTAGGGACATGGGAAAAACCACTGCTATGCC ATTTCTTCTCTCTGTTCCCTTCCTCACCCCCGACGGTGTGGCTGATGATGTCTTCTGGTGTCATGGTGACCACCCCCTGTTCCCTGTTCT GGTATTTCCCCTGTCAGTTTCCCCTCTCGGCCAGGTTGTGTCCCAAAATCCCCTCAGCCTCTTCTCTGCACGTTGCTGAAGGTCCAGGCT >7909_7909_1_ATP4A-FKBP4_ATP4A_chr19_36049894_ENST00000262623_FKBP4_chr12_2908253_ENST00000001008_length(amino acids)=706AA_BP=418 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNA LRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQA TVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVV NTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAK RLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSVALEGYYKDKLFDQRELRFEIGEGENLDLPYG LERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQY KKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLY -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ATP4A-FKBP4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | FKBP4 | chr19:36049894 | chr12:2908253 | ENST00000001008 | 3 | 10 | 267_400 | 171.33333333333334 | 460.0 | tubulin |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ATP4A-FKBP4 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ATP4A | P20648 | DB00213 | Pantoprazole | Inhibitor | Small molecule | Approved |
Hgene | ATP4A | P20648 | DB00448 | Lansoprazole | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ATP4A | P20648 | DB00736 | Esomeprazole | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ATP4A | P20648 | DB01129 | Rabeprazole | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ATP4A | P20648 | DB05351 | Dexlansoprazole | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ATP4A | P20648 | DB00338 | Omeprazole | Inhibitor | Small molecule | Approved|Investigational|Vet_approved |
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Related Diseases for ATP4A-FKBP4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0041696 | Unipolar Depression | 3 | PSYGENET | |
Tgene | C1269683 | Major Depressive Disorder | 3 | PSYGENET |