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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATP6V0A4-TM4SF20 (FusionGDB2 ID:HG50617TG79853)

Fusion Gene Summary for ATP6V0A4-TM4SF20

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP6V0A4-TM4SF20
Fusion gene ID: hg50617tg79853
HgeneTgene
Gene symbol

ATP6V0A4

TM4SF20

Gene ID

50617

79853

Gene nameATPase H+ transporting V0 subunit a4transmembrane 4 L six family member 20
SynonymsA4|ATP6N1B|ATP6N2|RDRTA2|RTA1C|RTADR|STV1|VPH1|VPP2PRO994|SLI5|TCCE518
Cytomap('ATP6V0A4')('TM4SF20')

7q34

2q36.3

Type of geneprotein-codingprotein-coding
DescriptionV-type proton ATPase 116 kDa subunit a isoform 4V-type proton ATPase 116 kDa subunit aATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1BATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic actransmembrane 4 L6 family member 20
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000310018, ENST00000393054, 
ENST00000353492, ENST00000483139, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ATP6V0A4 [Title/Abstract] AND TM4SF20 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP6V0A4(138406642)-TM4SF20(228235696), # samples:3
Anticipated loss of major functional domain due to fusion event.ATP6V0A4-TM4SF20 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTM4SF20

GO:0045861

negative regulation of proteolysis

25310401|27499293


check buttonFusion gene breakpoints across ATP6V0A4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TM4SF20 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N8-A56S-01AATP6V0A4chr7

138406642

-TM4SF20chr2

228235696

-
ChimerDB4UCSTCGA-N8-A56SATP6V0A4chr7

138406642

-TM4SF20chr2

228235696

-


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Fusion Gene ORF analysis for ATP6V0A4-TM4SF20

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000310018ENST00000304568ATP6V0A4chr7

138406642

-TM4SF20chr2

228235696

-
Frame-shiftENST00000393054ENST00000304568ATP6V0A4chr7

138406642

-TM4SF20chr2

228235696

-
In-frameENST00000353492ENST00000304568ATP6V0A4chr7

138406642

-TM4SF20chr2

228235696

-
intron-3CDSENST00000483139ENST00000304568ATP6V0A4chr7

138406642

-TM4SF20chr2

228235696

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000353492ATP6V0A4chr7138406642-ENST00000304568TM4SF20chr2228235696-43022227492733894

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000353492ENST00000304568ATP6V0A4chr7138406642-TM4SF20chr2228235696-0.000543610.99945635

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Fusion Genomic Features for ATP6V0A4-TM4SF20


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ATP6V0A4-TM4SF20


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:138406642/chr2:228235696)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-19221_390713841.0Topological domainCytoplasmic
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-1922410_411713841.0Topological domainVacuolar
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-1922429_443713841.0Topological domainCytoplasmic
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-1922474_538713841.0Topological domainVacuolar
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-1922559_576713841.0Topological domainCytoplasmic
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-1922598_642713841.0Topological domainVacuolar
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-18211_390713841.0Topological domainCytoplasmic
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-1821410_411713841.0Topological domainVacuolar
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-1821429_443713841.0Topological domainCytoplasmic
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-1821474_538713841.0Topological domainVacuolar
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-1821559_576713841.0Topological domainCytoplasmic
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-1821598_642713841.0Topological domainVacuolar
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-18211_390713841.0Topological domainCytoplasmic
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-1821410_411713841.0Topological domainVacuolar
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-1821429_443713841.0Topological domainCytoplasmic
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-1821474_538713841.0Topological domainVacuolar
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-1821559_576713841.0Topological domainCytoplasmic
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-1821598_642713841.0Topological domainVacuolar
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-1922391_409713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-1922412_428713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-1922444_473713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-1922539_558713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-1922577_597713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-1922643_662713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-1821391_409713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-1821412_428713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-1821444_473713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-1821539_558713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-1821577_597713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-1821643_662713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-1821391_409713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-1821412_428713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-1821444_473713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-1821539_558713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-1821577_597713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-1821643_662713841.0TransmembraneHelical
TgeneTM4SF20chr7:138406642chr2:228235696ENST0000030456804105_18561230.0Topological domainCytoplasmic
TgeneTM4SF20chr7:138406642chr2:228235696ENST0000030456804207_22961230.0Topological domainLumenal
TgeneTM4SF20chr7:138406642chr2:228235696ENST000003045680466_8361230.0Topological domainLumenal
TgeneTM4SF20chr7:138406642chr2:228235696ENST0000030456804186_20661230.0TransmembraneHelical
TgeneTM4SF20chr7:138406642chr2:228235696ENST000003045680484_10461230.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-1922663_727713841.0Topological domainCytoplasmic
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-1922753_773713841.0Topological domainVacuolar
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-1922813_840713841.0Topological domainCytoplasmic
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-1821663_727713841.0Topological domainCytoplasmic
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-1821753_773713841.0Topological domainVacuolar
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-1821813_840713841.0Topological domainCytoplasmic
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-1821663_727713841.0Topological domainCytoplasmic
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-1821753_773713841.0Topological domainVacuolar
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-1821813_840713841.0Topological domainCytoplasmic
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-1922728_752713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000310018-1922774_812713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-1821728_752713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000353492-1821774_812713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-1821728_752713841.0TransmembraneHelical
HgeneATP6V0A4chr7:138406642chr2:228235696ENST00000393054-1821774_812713841.0TransmembraneHelical
TgeneTM4SF20chr7:138406642chr2:228235696ENST00000304568041_1461230.0Topological domainLumenal
TgeneTM4SF20chr7:138406642chr2:228235696ENST000003045680436_4461230.0Topological domainCytoplasmic
TgeneTM4SF20chr7:138406642chr2:228235696ENST000003045680415_3561230.0TransmembraneHelical
TgeneTM4SF20chr7:138406642chr2:228235696ENST000003045680445_6561230.0TransmembraneHelical


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Fusion Gene Sequence for ATP6V0A4-TM4SF20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8105_8105_1_ATP6V0A4-TM4SF20_ATP6V0A4_chr7_138406642_ENST00000353492_TM4SF20_chr2_228235696_ENST00000304568_length(transcript)=4302nt_BP=2227nt
GCTGGAGGCTGTGCTGAGTGCCCGGTGCAGGTGAGCCGGTCCTGCGGAGTTGTGCCGAGTGCCTGCTGCAGACCGAGGCTGGGCCAAGAT
GGTGTCTGTGTTTCGAAGCGAGGAGATGTGTTTGTCACAACTGTTTCTCCAGGTGGAAGCTGCATATTGCTGTGTGGCTGAGCTCGGAGA
GCTCGGATTGGTTCAGTTCAAAGATTTAAATATGAATGTGAACAGCTTTCAAAGGAAATTTGTGAATGAAGTCAGAAGGTGTGAATCACT
GGAGAGAATCCTCCGTTTTCTGGAAGACGAGATGCAAAATGAGATTGTAGTTCAGTTGCTCGAGAAAAGCCCACTGACCCCGCTCCCACG
GGAAATGATTACCCTGGAGACTGTTCTAGAAAAACTGGAAGGAGAGTTACAGGAAGCCAACCAGAACCAGCAGGCCTTGAAACAAAGCTT
CCTAGAACTGACAGAACTGAAATACCTCCTGAAGAAAACCCAAGACTTCTTTGAGACGGAAACCAATTTAGCTGATGATTTCTTTACTGA
GGACACTTCTGGCCTCCTGGAGTTGAAAGCAGTGCCTGCATATATGACCGGAAAGTTGGGGTTCATAGCCGGTGTGATCAACAGGGAGAG
GATGGCTTCCTTTGAGCGGTTACTGTGGCGAATCTGCCGAGGAAACGTGTACTTGAAGTTCAGTGAGATGGACGCCCCTCTGGAGGATCC
TGTGACGAAAGAAGAAATTCAGAAGAACATATTCATCATATTTTACCAAGGAGAGCAGCTCAGGCAGAAAATCAAGAAGATCTGTGATGG
GTTTCGAGCCACTGTCTACCCTTGCCCAGAGCCTGCGGTGGAGCGCAGAGAGATGTTGGAGAGCGTCAATGTGAGGCTGGAAGATTTAAT
CACCGTCATAACACAAACAGAGTCTCACCGCCAGCGCCTGCTGCAGGAAGCCGCTGCCAACTGGCACTCCTGGCTCATCAAGGTGCAGAA
GATGAAAGCTGTCTACCACATCCTGAACATGTGCAACATCGACGTCACCCAGCAGTGTGTCATCGCCGAGATCTGGTTCCCGGTGGCAGA
TGCCACACGTATCAAGAGGGCACTGGAGCAAGGCATGGAACTAAGTGGCTCCTCCATGGCCCCCATCATGACCACAGTGCAATCTAAAAC
AGCCCCTCCCACATTTAACAGGACCAATAAATTCACAGCTGGCTTCCAGAATATTGTTGATGCCTATGGTGTCGGCAGCTACCGGGAGAT
AAACCCAGCCCCCTACACCATCATCACTTTCCCCTTCCTGTTCGCTGTGATGTTTGGAGACTGTGGTCATGGAACCGTGATGCTCCTGGC
TGCACTTTGGATGATTCTGAATGAGAGACGCTTGCTCTCCCAGAAGACAGACAATGAGATTTGGAACACCTTCTTCCACGGGCGCTATCT
GATCCTACTTATGGGCATCTTCTCCATCTACACGGGTTTGATCTACAATGACTGCTTCTCCAAGTCCTTGAACATCTTTGGCTCTTCTTG
GAGTGTCCAACCCATGTTCAGAAACGGCACATGGAATACTCATGTAATGGAGGAAAGTCTATATCTGCAGCTGGACCCAGCCATACCAGG
AGTGTATTTTGGAAATCCATACCCGTTTGGGATTGATCCGATTTGGAACTTGGCTTCAAACAAACTCACATTTCTGAACTCGTATAAAAT
GAAGATGTCGGTGATCCTGGGAATTGTCCAGATGGTTTTCGGTGTCATCCTCAGCCTTTTCAATCACATATACTTCAGAAGAACTCTCAA
CATCATTCTGCAATTTATCCCTGAGATGATTTTTATCCTGTGTCTGTTTGGATACCTGGTTTTCATGATCATTTTCAAATGGTGCTGCTT
TGACGTCCATGTATCTCAGCACGCCCCCAGCATCCTCATCCACTTCATCAACATGTTTCTGTTTAACTACAGTGACTCTTCCAACGCACC
CCTCTACAAACATCAGCAAGAAGTCCAAAGTTTCTTTGTGGTTATGGCTTTGATTTCTGTGCCGTGGATGCTTCTGATTAAGCCGTTTAT
TCTTAGAGCCAGTCATCGGAAATCCCAGCTGCAGGCATCCAGGATCCAAGAAGATGCCACTGAGAACATTGAAGGTGATAGCTCCAGCCC
TTCTAGCCGTTCTGGCCAGAGGACTTCTGCAGATACCCACGGGGCTCTGGACGACCATGGAGAAGAGGCCATTCCAGCAACAACAATGTC
CTTGACAGCAAGAAAAAGAGCGTGCTGCAACAACAGAACTGGAATGTTTCTTTCATCACTTTTCAGTGTGATCACAGTCATTGGTGCTCT
GTATTGCATGCTGATATCCATCCAGGCTCTCTTAAAAGGTCCTCTCATGTGTAATTCTCCAAGCAACAGTAATGCCAATTGTGAATTTTC
ATTGAAAAACATCAGTGACATTCATCCAGAATCCTTCAACTTGCAGTGGTTTTTCAATGACTCTTGTGCACCTCCTACTGGTTTCAATAA
ACCCACCAGTAACGACACCATGGCGAGTGGCTGGAGAGCATCTAGTTTCCACTTCGATTCTGAAGAAAACAAACATAGGCTTATCCACTT
CTCAGTATTTTTAGGTCTATTGCTTGTTGGAATTCTGGAGGTCCTGTTTGGGCTCAGTCAGATAGTCATCGGTTTCCTTGGCTGTCTGTG
TGGAGTCTCTAAGCGAAGAAGTCAAATTGTGTAGTTTAATGGGAATAAAATGTAAGTATCAGTAGTTTGAATTAATTTGAGAAGTACACT
TGTTTTCAAAGTCATCTTTGAGATGATTTAAAAAATCAACCCTTCACGTAGAAAGCACGTTGTAAATGCATAACACTCTCATATCAGTGG
TTGATTTGGGAAAGGTGGAGAGAATTTTCAATTAGTTTTGTGTTGTACTATTCAAATTTTTTACCTCTTCACTGTGTGTAGAGAAAGGAG
AAGGGAAGGAGGATGAGAAGGAACGGAAGTCATCCTGAAAATAAAAGTACAGGACTTTTTTTTTTTTTTTTTGAGACAGGGTCTCAAAAA
AGGCTGGAGTACAGTAGTACAGTGGTGCTATCTCAGCTTACTGCAGCCTCAACCTCCTGGGCTCAGGTGATTCTCCCATCTCAGCCTCCC
TAGTAGCTGGGACTACAGGTGCGTGCCACTATGCCAAGCTAATTTTTGTATTTTTAGTAGAGATGGGGGTTTTCCATATTGCCCAGGCTG
GTCCCGAACTCATGGACTCAAGTGATCTGCCTGCCTCAGCCTCCTAAAGTGCTGCGATTACAGGCATGAGCCATCGCGCCTAAAGGACAG
GACCTTTTTATTGTATTTCTTTAAAGAATAAATACATAACCTGAATGCAATCAAGTCTTTAGATCTAATTCTCAGCTTGCAGGGAACACT
AGGACAAATCCAAAAAGTGGGTCAGCGGGCACAGAATGGCCCAATTTTCAACAGGAAAATGTTATAAAAGAAAAATATTTTTGAGGGAAC
TGTTATAGATTAAGAGAATAGAGGCATGTTTCAGCTAAACACATGTAAACTTTGTCAGAGATAATTGGGAGGAGTATGTAGAAGAATCGG
ATTATTGTTAATTTTGGTAGGTCTGATAATGGTTTTATAGTATAAAGGCTGAGTACCCCTTATCCAAAATGATTAAGATCAGAAGTGTTT
TGGCTTTCACATTTTTTTGGATTTTGGAATTTTGCCTATAATAATGAGACATCTTGGGGATGGGATGCAAGTCTAACCACAAAATTCATT
TATGTCTCATACACACTTTGAACACCTGGCCTGAAGGTAATTTCACACAATATTTTAAATAACTTTGTGCATGAAACACAATTTTGACTG
CATTTTGACTGCAACTCATCACATGAGGTCAGGTATGGAATTTTCCACTTGTGGTGTTACGTTACTGGCTCAAAAAGTTTTGGATCTCGG
AGCATTCTGGATTTTGAATTTTTGGATTAGTGATGCTCAACCTGTATACAGAAATGTCCTCATTTTTAAAAAAAGAAATGCATATTTATA
TGTTTTAAAATTACTTCAACCAAAAGCAACGGGGAGATGTTTACTGTTATATTTAGGTGACAGGTACATGGCAATTCATTATACCCTCCT
ATTTTCCTATGTTTACATTATTCATTAATTAAAAAACAATACCTAGAAAAACCCAAGACTTTCAAAAGCTATTTTCTATATGTGCCAATC

>8105_8105_1_ATP6V0A4-TM4SF20_ATP6V0A4_chr7_138406642_ENST00000353492_TM4SF20_chr2_228235696_ENST00000304568_length(amino acids)=894AA_BP=726
MCRVPAADRGWAKMVSVFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLERILRFLEDEMQNEIV
VQLLEKSPLTPLPREMITLETVLEKLEGELQEANQNQQALKQSFLELTELKYLLKKTQDFFETETNLADDFFTEDTSGLLELKAVPAYMT
GKLGFIAGVINRERMASFERLLWRICRGNVYLKFSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKKICDGFRATVYPCPEPAVERR
EMLESVNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQKMKAVYHILNMCNIDVTQQCVIAEIWFPVADATRIKRALEQGMELSG
SSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVMFGDCGHGTVMLLAALWMILNERRLLSQKT
DNEIWNTFFHGRYLILLMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVMEESLYLQLDPAIPGVYFGNPYPFGIDPIWN
LASNKLTFLNSYKMKMSVILGIVQMVFGVILSLFNHIYFRRTLNIILQFIPEMIFILCLFGYLVFMIIFKWCCFDVHVSQHAPSILIHFI
NMFLFNYSDSSNAPLYKHQQEVQSFFVVMALISVPWMLLIKPFILRASHRKSQLQASRIQEDATENIEGDSSSPSSRSGQRTSADTHGAL
DDHGEEAIPATTMSLTARKRACCNNRTGMFLSSLFSVITVIGALYCMLISIQALLKGPLMCNSPSNSNANCEFSLKNISDIHPESFNLQW

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Fusion Gene PPI Analysis for ATP6V0A4-TM4SF20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATP6V0A4-TM4SF20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATP6V0A4-TM4SF20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATP6V0A4C1864498RENAL TUBULAR ACIDOSIS, DISTAL, AUTOSOMAL RECESSIVE3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC3809483SPECIFIC LANGUAGE IMPAIRMENT 51CTD_human;GENOMICS_ENGLAND