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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGEF3-ACP6 (FusionGDB2 ID:HG50650TG51205)

Fusion Gene Summary for ARHGEF3-ACP6

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF3-ACP6
Fusion gene ID: hg50650tg51205
HgeneTgene
Gene symbol

ARHGEF3

ACP6

Gene ID

50650

51205

Gene nameRho guanine nucleotide exchange factor 3acid phosphatase 6, lysophosphatidic
SynonymsGEF3|STA3|XPLNACPL1|LPAP|PACPL1
Cytomap('ARHGEF3')('ACP6')

3p14.3

1q21.2

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 359.8 kDA proteinRho guanine nucleotide exchange factor (GEF) 3RhoGEF proteinexchange factor found in platelets and leukemic and neuronal tissues, XPLNlysophosphatidic acid phosphatase type 6acid phosphatase-like protein 1
Modification date2020032720200313
UniProtAcc

Q9NR81

.
Ensembl transtripts involved in fusion geneENST00000338458, ENST00000496106, 
ENST00000498517, ENST00000296315, 
ENST00000413728, ENST00000495373, 
ENST00000497267, 
Fusion gene scores* DoF score19 X 17 X 8=25842 X 2 X 2=8
# samples 233
** MAII scorelog2(23/2584*10)=-3.48990030374955
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/8*10)=1.90689059560852
Context

PubMed: ARHGEF3 [Title/Abstract] AND ACP6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF3(56916320)-ACP6(147131890), # samples:3
Anticipated loss of major functional domain due to fusion event.ARHGEF3-ACP6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF3-ACP6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACP6

GO:2001311

lysobisphosphatidic acid metabolic process

23807634


check buttonFusion gene breakpoints across ARHGEF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ACP6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A0J6-01AARHGEF3chr3

56916320

-ACP6chr1

147131890

-
ChimerDB4BRCATCGA-AO-A0J6ARHGEF3chr3

56916319

-ACP6chr1

147131890

-


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Fusion Gene ORF analysis for ARHGEF3-ACP6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000338458ENST00000392988ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
5CDS-intronENST00000338458ENST00000392988ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
5CDS-intronENST00000338458ENST00000460583ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
5CDS-intronENST00000338458ENST00000460583ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
5CDS-intronENST00000496106ENST00000392988ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
5CDS-intronENST00000496106ENST00000392988ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
5CDS-intronENST00000496106ENST00000460583ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
5CDS-intronENST00000496106ENST00000460583ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
5UTR-3CDSENST00000498517ENST00000369238ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
5UTR-3CDSENST00000498517ENST00000369238ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
5UTR-intronENST00000498517ENST00000392988ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
5UTR-intronENST00000498517ENST00000392988ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
5UTR-intronENST00000498517ENST00000460583ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
5UTR-intronENST00000498517ENST00000460583ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
In-frameENST00000338458ENST00000369238ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
In-frameENST00000338458ENST00000369238ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
In-frameENST00000496106ENST00000369238ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
In-frameENST00000496106ENST00000369238ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
intron-3CDSENST00000296315ENST00000369238ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-3CDSENST00000296315ENST00000369238ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
intron-3CDSENST00000413728ENST00000369238ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-3CDSENST00000413728ENST00000369238ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
intron-3CDSENST00000495373ENST00000369238ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-3CDSENST00000495373ENST00000369238ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
intron-3CDSENST00000497267ENST00000369238ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-3CDSENST00000497267ENST00000369238ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
intron-intronENST00000296315ENST00000392988ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-intronENST00000296315ENST00000392988ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
intron-intronENST00000296315ENST00000460583ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-intronENST00000296315ENST00000460583ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
intron-intronENST00000413728ENST00000392988ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-intronENST00000413728ENST00000392988ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
intron-intronENST00000413728ENST00000460583ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-intronENST00000413728ENST00000460583ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
intron-intronENST00000495373ENST00000392988ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-intronENST00000495373ENST00000392988ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
intron-intronENST00000495373ENST00000460583ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-intronENST00000495373ENST00000460583ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
intron-intronENST00000497267ENST00000392988ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-intronENST00000497267ENST00000392988ARHGEF3chr3

56916319

-ACP6chr1

147131890

-
intron-intronENST00000497267ENST00000460583ARHGEF3chr3

56916320

-ACP6chr1

147131890

-
intron-intronENST00000497267ENST00000460583ARHGEF3chr3

56916319

-ACP6chr1

147131890

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000338458ARHGEF3chr356916320-ENST00000369238ACP6chr1147131890-65613021101369419
ENST00000496106ARHGEF3chr356916320-ENST00000369238ACP6chr1147131890-6485226821293403
ENST00000338458ARHGEF3chr356916319-ENST00000369238ACP6chr1147131890-65613021101369419
ENST00000496106ARHGEF3chr356916319-ENST00000369238ACP6chr1147131890-6485226821293403

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000338458ENST00000369238ARHGEF3chr356916320-ACP6chr1147131890-0.0003262550.9996737
ENST00000496106ENST00000369238ARHGEF3chr356916320-ACP6chr1147131890-0.0002455730.99975437
ENST00000338458ENST00000369238ARHGEF3chr356916319-ACP6chr1147131890-0.0003262550.9996737
ENST00000496106ENST00000369238ARHGEF3chr356916319-ACP6chr1147131890-0.0002455730.99975437

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Fusion Genomic Features for ARHGEF3-ACP6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARHGEF3-ACP6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:56916320/chr1:147131890)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGEF3

Q9NR81

.
FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. {ECO:0000269|PubMed:12221096}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF3chr3:56916319chr1:147131890ENST00000296315-110122_3040527.0DomainDH
HgeneARHGEF3chr3:56916319chr1:147131890ENST00000296315-110291_4490527.0DomainPH
HgeneARHGEF3chr3:56916319chr1:147131890ENST00000338458-413122_30464559.0DomainDH
HgeneARHGEF3chr3:56916319chr1:147131890ENST00000338458-413291_44964559.0DomainPH
HgeneARHGEF3chr3:56916319chr1:147131890ENST00000413728-110122_3040533.0DomainDH
HgeneARHGEF3chr3:56916319chr1:147131890ENST00000413728-110291_4490533.0DomainPH
HgeneARHGEF3chr3:56916320chr1:147131890ENST00000296315-110122_3040527.0DomainDH
HgeneARHGEF3chr3:56916320chr1:147131890ENST00000296315-110291_4490527.0DomainPH
HgeneARHGEF3chr3:56916320chr1:147131890ENST00000338458-413122_30464559.0DomainDH
HgeneARHGEF3chr3:56916320chr1:147131890ENST00000338458-413291_44964559.0DomainPH
HgeneARHGEF3chr3:56916320chr1:147131890ENST00000413728-110122_3040533.0DomainDH
HgeneARHGEF3chr3:56916320chr1:147131890ENST00000413728-110291_4490533.0DomainPH
TgeneACP6chr3:56916319chr1:147131890ENST0000036923801058_16873429.0RegionSubstrate binding
TgeneACP6chr3:56916319chr1:147131890ENST000003929880758_16873272.0RegionSubstrate binding
TgeneACP6chr3:56916320chr1:147131890ENST0000036923801058_16873429.0RegionSubstrate binding
TgeneACP6chr3:56916320chr1:147131890ENST000003929880758_16873272.0RegionSubstrate binding


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Fusion Gene Sequence for ARHGEF3-ACP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6308_6308_1_ARHGEF3-ACP6_ARHGEF3_chr3_56916319_ENST00000338458_ACP6_chr1_147131890_ENST00000369238_length(transcript)=6561nt_BP=302nt
AGCCCAGGGGAGCCGCCGCCGCAGCCGCCGCCGCCGCGGTGAGTTTTCCAGCCTGGAGAGGCCGAACCAGCGCGGGGGTCGAGGAGACCT
GAGCCTGCCATACTGAGTCTATGGACAGTTCCACAGCAATGAATCAATGCAGCTGTAGAGGAATGGAAGAAAACAAGGAAAGGCCTAAAC
GGCAGCGGCAAAACAACTTTCCCATGTTTCCCTCTCCTAAAGCCTGGAATTTCAGAGGGCGAAAACGGAAACAGAGCACCCAAGATGAAG
ATGCTGTTAGCCTTTGCAGTCTCGACATAAGTGTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCAGTTTGATTACACAG
TCACCAATCTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGGCATGTTTGCTGGGC
AGCTGACCAAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCCCTTTCTTTCACCAA
CCTTCAACCCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGCTGGGCTTTTCCAGT
GTCAGAAAGAAGGACCCATCATCATCCACACTGATGAAGCAGATTCAGAAGTCTTGTATCCCAACTACCAAAGCTGCTGGAGCCTGAGGC
AGAGAACCAGAGGCCGGAGGCAGACTGCCTCTTTACAGCCAGGAATCTCAGAGGATTTGAAAAAGGTGAAGGACAGGATGGGCATTGACA
GTAGTGATAAAGTGGACTTCTTCATCCTCCTGGACAACGTGGCTGCCGAGCAGGCACACAACCTCCCAAGCTGCCCCATGCTGAAGAGAT
TTGCAAGGATGATCGAACAGAGAGCTGTGGACACATCCTTGTACATACTGCCCAAGGAAGACAGGGAAAGTCTTCAGATGGCAGTAGGCC
CATTCCTCCACATCCTAGAGAGCAACCTGCTGAAAGCCGTGGACTCTGCCACTGCCCCCGACAAGATCAGAAAGCTGTATCTCTATGCGG
CTCATGATGTGACCTTCATACCGCTCTTAATGACCCTGGGGATTTTTGACCACAAATGGCCACCGTTTGCTGTTGACCTGACCATGGAAC
TTTACCAGCACCTGGAATCTAAGGAGTGGTTTGTGCAGCTCTATTACCACGGGAAGGAGCAGGTGCCGAGAGGTTGCCCTGATGGGCTCT
GCCCGCTGGACATGTTCTTGAATGCCATGTCAGTTTATACCTTAAGCCCAGAAAAATACCACGCACTCTGCTCTCAAACTCAGGTGATGG
AAGTTGGAAATGAAGAGTAACTGATTTATAAAAGCAGGATGTGTTGATTTTAAAATAAAGTGCCTTTATACAATGCCTCCTGCTTTGTGT
GTTTGGGAAGAGGAGAGAGCAAGGGGTAATGTACTTTAATATAATGTAAGGATATTTCCTTTCTGTGGGTTTACTAAGATTTCTTCCTGA
ACGGAAAAGGGGTATAATATTGAGACCAAAAGGATATTTCTCTATTTTGTGAGTTGGTTTCTAAGGTTAGAAGCATCTTTGTGTGACACG
GGCTGGGGACATCATGACCCTGTAGAATTGTGTCGGTTTTGGACTTTAGTTCTTTTCTCCTATATTAATTTCACATGTATTGAGCTACCT
ACTAAGTAGTGATCATTATAAAGGTGAAAACACTCTGCCCTCAAGTTGTTGCAGTCCAGTGGGAGAGGCAGCCGAGTAAATCAGTGATAC
AGTGCTGTATGTTTTATGCTGTAATAGGTATTTGAGGGGCTATTTGGGTATAGAGAAGAAACTTCCTGCTCACATGGCAGGGGATGTGGG
GAACAGTCAAGGAAGGCTTCTGAAAAAGTCCTGGCCTGATCTGAGTAGAGAAAGGTGGGTAGGAGTTAACCAGGAAAGCAAGGATGAAAG
CGTGTTGCGTTTAGATAAAGGATAGGCTTCAAGGTCAGGGAACGTTGCTGGGTGGTGAGATGGAACCCTGATGTGGAGGCTCAGCAGGAA
GAAGCAGGAAGGACACTGGGCCCCTGGTGGTTTTAGTTCCAGAAACAAATGTGGGCCCCAGGGCTCTGCAATGGTAAGGCTGGAACTACT
CAACATAAGAGCTCCACCTTTAACTGTGCCCCCTAAGAGTACCTGATGATCCCCCTATCTCCTTGTCAATGTTGCTGTTCTTCTCCAGAA
TCTATTTCAACCCTTCTCTGATTTCAAACCACCAGTCCCTTTACCTCTCAGAGAAAACAGCAACCACAAAAGCCTCTCCACTTCCTACTA
TCTTAATATTGACAACTTCCAGATCAGGGAGCTGAGATATCTCAAGCTCAGGTTTCTCTTCTGAGCTTCAGACGCTTTTATCCACTTGGA
TTTCACTGGCACAAAACTTTCCATGTTAGAATCAAACCCCCCTCCTCCCAGACCTGCTTCTCCCACACACTTCCCTATCTGAATGAAAGA
CACCTCCACTCTCCACCCAGTTGCCAAATCAGAAATCTGTCTTTGTTTTCTTTGTCTCACATTTTCCTATGTCTAATCAGTTAAGTTTTA
TCAATACTACCTGTTTATTTCTTTAATCTATTCACATATCTTTATCCTCAATCTTCAGCATCCCCTTCCCATCCTCAGTCTGCTGGTTAC
TGTATTTCCTATTTTACTAAGAATCTAAAAGAGATCAGAAGAAAACTTCCACATCCCCCAACACCCAACCACCAAATCTGCTAACCCAGT
TGCATTGGTGCTTTTATAGCCTTCCTTCCTCCCTCTTACTAAGAATGAACCAACACTATTCCTATCAAAGCCCAACCCTCTAGCTTTACA
TTGACTCCTAGTGTCTTTTTTCTGGATTGTCAATTTTTTTCCTGACCAATTATTCTATTAGCAATACAAATATGCTGTAAAATCTCTTAA
ACTTTTTTCTCTGCATCTTTGAACTGCTGTTCTCTTTTCCTTCTCCCCTTCATAGCAGAACTCCTCAAAAGAGTTGCTACCTCTAATTCT
TCCCTTCCAGTTCTCTCATGAACCAGCTACAATTAAGTATTCACCCCCACCACTCCATGGAAACTGCTCTTGTCAAAATCATCAATAGCC
TTTGTGTGGTGAATCCAATAGCCAGTTTTCATTCTTCTTACTAAGCTTCTCATCAGTATTCCTAGACTATTTCCTTCACTGGCTTCGACA
AATGCTTTCTTGGTTTTCCTCCAATTTCTCGACTTTGTTCCTGCTGAATCTACCTTTTTCTAATCCGTAAGTGTTGGGGTGTCCCAGGGC
TTACTCCTTGGACCTTTTTTCCACCTTTTCCCCTACACTCACCCACTAGGTGATCTCAAGAATTTCCAGTTTGAGGCCGGGCGCGGTGGC
TCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGGCCAGGAGTTCGAGACCAGCCTGGCCAACATGGCAAA
ACCCTGTCTCCACTAAACCTGCCTCTACTAAAAATACAAAAATTATTATATTTTTATAAAATTATTATAATTTTATAAAATTATTATATT
TATGGAGTACAATGTGATGTAATCCCAGCTACTCGGAAGGCTGTATGTGTCTATTTATGGAGTACAATGTGCCTGTAATCCCAGCTACTT
GGGAGGCTGAGGCAGGAGAATCACTTCAACCTAGGAGGCAGAGGTTGTGCTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACA
AGAGAGAAATAACATCTCAAAAAAAAAAAAAAAGAATTTCCAGTTTTAAATATTTACACAATGTCTCCTAAATTTATACCTTCAACCTAG
ACCTTTCCCTGTGAATCCCAGTCTCATTTCCAACAGTCTAATCAATGTCTCTATTTGGATGTTTAAGATATACAATAGGTATCAAACTTC
CCATTGTCCACAATAAACTCTCAATTTCCGTGCCTTTTCAAACTTACTCCTTCCACAGGCTTTCCCATCTAGGTAAATGACACCACCATT
CACCCTGTTGCTTTGGCCAAGAACTTTAGAACTGCCCTTGACTCCCCTCTTTTTCTCATATCCTACCTCTACTACATCAGTAACTCCTGT
TGTATCTCTCTTCAAACTATATCCAGAATTGACCATGTCCCAATACTTCCATTGCTACTGTCTTAGTCCCAGTGTCATCTTTTACCTGGA
TTATTGTAAAGGCCTCGTAACTAGTCTTCCTGTTTCTGCCCTTCCCTTCTCTGCCCATCTATTCTCAACACAGTGTTGCTTTTAAAACAA
AGTAAGATCGTGCCACTCTTCTGCTCTAAATTCCCCATTGGTTTCTCATCTCAAACTAAGGGCCAGTCATAATGCCCTCACGGTCCTATG
ACATCTCACTGCACCCCAGCCATACTCGCCATCTTACCATTCTTCTTCTTTTTTGTAATAAAAACTTTTTACTTTCTTTTTAGTTGACAG
ATAATAATTGCGTATATTTATGGAGTACAATGTGATGTTTTGATATATGTATGCATGAGGGAATGATTAAATCAAGCTAATTAACATATT
CATCACTTCATCTACTCATCACTTTCTTGTGGTGAAAATGTTTCAGATATACTCTTTAGTAGTTTTCAGGTGTACAGTCGCTGTGGTTTG
AGTGCTTTTGTCTTCTCTAAATTTGATGTTGACACTTAGTGCCCAGTACAATGTTACTGGGAGGTGGAGCCTAATGGGGATGTTTAATGG
ATTAATGCCATTATAAAAAGGGCTTGCAGGAATGGGTTCCTTCTCTTTTGCTTTTCTGCCATATGATGACAAAGTGTTCCTCCTCTCTGG
AGGATGCAGCAACAGGCACCATCTTTGAAGCAGAGAGACCAGGCCCTAACCTTCTGGTGCCTTGATCTTGGACTTCTCAGCTTCCAGAAC
TGTGAGATAATAAATTTCTGTTCATTACAAATTACCCCATCTGTGGTATTCTGTTATAGCAACACAAAATGGACTAAGACAACAGTATAC
TGTTATGAACTATGGTCACCATGCTGTGCACTAGATCACAAAAACTTATTTCTACTGTTTAACTGAAACTTTGTACATTTTGACTAACAT
CTCCCTTTTTCCCATCATCCCATCCCATTCTTACTATCGTTGAAGATGGAGTATGCCAAGTAGTCCTGAGCCATGTCCTCACCTCGGGGT
GAGCACCTGTTGTTCCTGTGCCTGGAATGCTCTCCTAGACATTTGCGTGGCTAGCTCCCTCTTTTCATTCAGATCTCAGCTCATTGTCAT
CTCAGAGAGGCCCTCCTTGCCCTCCTTCTACCTCCTGCCTTAGGTATACTCTGCCACCTTCTGTCATGGGCTGAATTGTGTCCCCCCTAA
ATCCATATGTTGACATCTTAACCCCTAGTACAGTAAGTCCTCACTTGATGCTATCAATAGGCTCTTGGAAATGTCGGCTTTCAGTGAAAG
GACATATAGCAGGTCCTTGAATAACATTGTGTTTTGTTCAACATCGTTGCCTTGTAACACTGATGAGCAAAACAGTTGGTTCTCTAATAT
GTTGTTTTACTTAAAGCTACAGTTTCCAAGAACCTATCAATGATGTTGAGGACTGAATGTACCTCAGGTGTAATGTATTTGGAGATAGGG
CCTTTTAAGAGGTAAAGTAAATGAGGTCATATGGGTAGGCTGTAATCCAATATGACTGGAATCCTTATAAGAAGAGGAAATGAGGACACA
GACACAGAGGGAAGATGACTATCTGCAAGTCAAGGAGAGAGGCCTCAGAAGAAACCAATGCTGCTGACACCACGATCTTGGACTTCTAGC
CTCTAGCACTGTGAGGAAATAAATTTCTGTTGTTTAAGCCACCTAGTCTGTGATACTTTGCTACGGCAGGCCCTAGCAAATGAATACACT
TGTCTTGTCTTTCCCCCGCCCTGTGATATTTATCAGTGCCGGATATTACATATTTGTGTATCTATATGCTTATTTCCCTGACTAAAATGG
AAGCTCCATGAAGGCAGATTTCCTCTTGTTCACTGATGTGTCCCCAGCACCTGGAATAGTGCCTAGTGCATGCCAGTGCTCAGACACTTG
GACATTTGAATGACATATCCCCTCTGTCACTTCTCTCCGGGGCCCAAGGCCACCCTCCTAGGTTACCACAGTGGCTTCCTAATGGGCCAT
ACCCTCACTTGCTTTCCATCACCCCCTGAGACCTGGCCCCTGCATACCTCTCCAGCTTCACCCCTCACATATCTCCCTAGCCAGACCTAT
AGTATGTTTTAAAAAAAAAGGAAATCGCACTCCTCTGGCCTCTTTACCTTGGCACACATTTTTCCATCACCTGACCCCTGACCCACACTC
CCTTTTCCTGTGTAATCCAATTATCTCTAGGCCTCCCGTGTTTCTGTTTGTCCTTCAATAGAAGGTTGTTTGTCTTGTCTTTTATTGTAT

>6308_6308_1_ARHGEF3-ACP6_ARHGEF3_chr3_56916319_ENST00000338458_ACP6_chr1_147131890_ENST00000369238_length(amino acids)=419AA_BP=64
MDSSTAMNQCSCRGMEENKERPKRQRQNNFPMFPSPKAWNFRGRKRKQSTQDEDAVSLCSLDISVEWNPQLLEVPPQTQFDYTVTNLAGG
PKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPI
IIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQ
RAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAVDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLES

--------------------------------------------------------------
>6308_6308_2_ARHGEF3-ACP6_ARHGEF3_chr3_56916319_ENST00000496106_ACP6_chr1_147131890_ENST00000369238_length(transcript)=6485nt_BP=226nt
ATGCAGCCCAAGTGGCGGGGAGGAGTTCCTTCAGGGAAACTATGCTCAGCCCTGTTCAGAGAATCCTGTGCACAGGGCTCCACTGCAGTT
AGGAGCCGGTGAGTCCGGGTGGATGAGGTCAGAGCGCCCCATGGTGTGGTGCTGCCTCTTTGTCCGTTCGCAGCGAAAACGGAAACAGAG
CACCCAAGATGAAGATGCTGTTAGCCTTTGCAGTCTCGACATAAGTGTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCA
GTTTGATTACACAGTCACCAATCTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGG
CATGTTTGCTGGGCAGCTGACCAAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCC
CTTTCTTTCACCAACCTTCAACCCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGC
TGGGCTTTTCCAGTGTCAGAAAGAAGGACCCATCATCATCCACACTGATGAAGCAGATTCAGAAGTCTTGTATCCCAACTACCAAAGCTG
CTGGAGCCTGAGGCAGAGAACCAGAGGCCGGAGGCAGACTGCCTCTTTACAGCCAGGAATCTCAGAGGATTTGAAAAAGGTGAAGGACAG
GATGGGCATTGACAGTAGTGATAAAGTGGACTTCTTCATCCTCCTGGACAACGTGGCTGCCGAGCAGGCACACAACCTCCCAAGCTGCCC
CATGCTGAAGAGATTTGCAAGGATGATCGAACAGAGAGCTGTGGACACATCCTTGTACATACTGCCCAAGGAAGACAGGGAAAGTCTTCA
GATGGCAGTAGGCCCATTCCTCCACATCCTAGAGAGCAACCTGCTGAAAGCCGTGGACTCTGCCACTGCCCCCGACAAGATCAGAAAGCT
GTATCTCTATGCGGCTCATGATGTGACCTTCATACCGCTCTTAATGACCCTGGGGATTTTTGACCACAAATGGCCACCGTTTGCTGTTGA
CCTGACCATGGAACTTTACCAGCACCTGGAATCTAAGGAGTGGTTTGTGCAGCTCTATTACCACGGGAAGGAGCAGGTGCCGAGAGGTTG
CCCTGATGGGCTCTGCCCGCTGGACATGTTCTTGAATGCCATGTCAGTTTATACCTTAAGCCCAGAAAAATACCACGCACTCTGCTCTCA
AACTCAGGTGATGGAAGTTGGAAATGAAGAGTAACTGATTTATAAAAGCAGGATGTGTTGATTTTAAAATAAAGTGCCTTTATACAATGC
CTCCTGCTTTGTGTGTTTGGGAAGAGGAGAGAGCAAGGGGTAATGTACTTTAATATAATGTAAGGATATTTCCTTTCTGTGGGTTTACTA
AGATTTCTTCCTGAACGGAAAAGGGGTATAATATTGAGACCAAAAGGATATTTCTCTATTTTGTGAGTTGGTTTCTAAGGTTAGAAGCAT
CTTTGTGTGACACGGGCTGGGGACATCATGACCCTGTAGAATTGTGTCGGTTTTGGACTTTAGTTCTTTTCTCCTATATTAATTTCACAT
GTATTGAGCTACCTACTAAGTAGTGATCATTATAAAGGTGAAAACACTCTGCCCTCAAGTTGTTGCAGTCCAGTGGGAGAGGCAGCCGAG
TAAATCAGTGATACAGTGCTGTATGTTTTATGCTGTAATAGGTATTTGAGGGGCTATTTGGGTATAGAGAAGAAACTTCCTGCTCACATG
GCAGGGGATGTGGGGAACAGTCAAGGAAGGCTTCTGAAAAAGTCCTGGCCTGATCTGAGTAGAGAAAGGTGGGTAGGAGTTAACCAGGAA
AGCAAGGATGAAAGCGTGTTGCGTTTAGATAAAGGATAGGCTTCAAGGTCAGGGAACGTTGCTGGGTGGTGAGATGGAACCCTGATGTGG
AGGCTCAGCAGGAAGAAGCAGGAAGGACACTGGGCCCCTGGTGGTTTTAGTTCCAGAAACAAATGTGGGCCCCAGGGCTCTGCAATGGTA
AGGCTGGAACTACTCAACATAAGAGCTCCACCTTTAACTGTGCCCCCTAAGAGTACCTGATGATCCCCCTATCTCCTTGTCAATGTTGCT
GTTCTTCTCCAGAATCTATTTCAACCCTTCTCTGATTTCAAACCACCAGTCCCTTTACCTCTCAGAGAAAACAGCAACCACAAAAGCCTC
TCCACTTCCTACTATCTTAATATTGACAACTTCCAGATCAGGGAGCTGAGATATCTCAAGCTCAGGTTTCTCTTCTGAGCTTCAGACGCT
TTTATCCACTTGGATTTCACTGGCACAAAACTTTCCATGTTAGAATCAAACCCCCCTCCTCCCAGACCTGCTTCTCCCACACACTTCCCT
ATCTGAATGAAAGACACCTCCACTCTCCACCCAGTTGCCAAATCAGAAATCTGTCTTTGTTTTCTTTGTCTCACATTTTCCTATGTCTAA
TCAGTTAAGTTTTATCAATACTACCTGTTTATTTCTTTAATCTATTCACATATCTTTATCCTCAATCTTCAGCATCCCCTTCCCATCCTC
AGTCTGCTGGTTACTGTATTTCCTATTTTACTAAGAATCTAAAAGAGATCAGAAGAAAACTTCCACATCCCCCAACACCCAACCACCAAA
TCTGCTAACCCAGTTGCATTGGTGCTTTTATAGCCTTCCTTCCTCCCTCTTACTAAGAATGAACCAACACTATTCCTATCAAAGCCCAAC
CCTCTAGCTTTACATTGACTCCTAGTGTCTTTTTTCTGGATTGTCAATTTTTTTCCTGACCAATTATTCTATTAGCAATACAAATATGCT
GTAAAATCTCTTAAACTTTTTTCTCTGCATCTTTGAACTGCTGTTCTCTTTTCCTTCTCCCCTTCATAGCAGAACTCCTCAAAAGAGTTG
CTACCTCTAATTCTTCCCTTCCAGTTCTCTCATGAACCAGCTACAATTAAGTATTCACCCCCACCACTCCATGGAAACTGCTCTTGTCAA
AATCATCAATAGCCTTTGTGTGGTGAATCCAATAGCCAGTTTTCATTCTTCTTACTAAGCTTCTCATCAGTATTCCTAGACTATTTCCTT
CACTGGCTTCGACAAATGCTTTCTTGGTTTTCCTCCAATTTCTCGACTTTGTTCCTGCTGAATCTACCTTTTTCTAATCCGTAAGTGTTG
GGGTGTCCCAGGGCTTACTCCTTGGACCTTTTTTCCACCTTTTCCCCTACACTCACCCACTAGGTGATCTCAAGAATTTCCAGTTTGAGG
CCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGGCCAGGAGTTCGAGACCAGCCTG
GCCAACATGGCAAAACCCTGTCTCCACTAAACCTGCCTCTACTAAAAATACAAAAATTATTATATTTTTATAAAATTATTATAATTTTAT
AAAATTATTATATTTATGGAGTACAATGTGATGTAATCCCAGCTACTCGGAAGGCTGTATGTGTCTATTTATGGAGTACAATGTGCCTGT
AATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTCAACCTAGGAGGCAGAGGTTGTGCTGAGCCAAGATCGTGCCATTGCACTC
CAGCCTGGGCAACAAGAGAGAAATAACATCTCAAAAAAAAAAAAAAAGAATTTCCAGTTTTAAATATTTACACAATGTCTCCTAAATTTA
TACCTTCAACCTAGACCTTTCCCTGTGAATCCCAGTCTCATTTCCAACAGTCTAATCAATGTCTCTATTTGGATGTTTAAGATATACAAT
AGGTATCAAACTTCCCATTGTCCACAATAAACTCTCAATTTCCGTGCCTTTTCAAACTTACTCCTTCCACAGGCTTTCCCATCTAGGTAA
ATGACACCACCATTCACCCTGTTGCTTTGGCCAAGAACTTTAGAACTGCCCTTGACTCCCCTCTTTTTCTCATATCCTACCTCTACTACA
TCAGTAACTCCTGTTGTATCTCTCTTCAAACTATATCCAGAATTGACCATGTCCCAATACTTCCATTGCTACTGTCTTAGTCCCAGTGTC
ATCTTTTACCTGGATTATTGTAAAGGCCTCGTAACTAGTCTTCCTGTTTCTGCCCTTCCCTTCTCTGCCCATCTATTCTCAACACAGTGT
TGCTTTTAAAACAAAGTAAGATCGTGCCACTCTTCTGCTCTAAATTCCCCATTGGTTTCTCATCTCAAACTAAGGGCCAGTCATAATGCC
CTCACGGTCCTATGACATCTCACTGCACCCCAGCCATACTCGCCATCTTACCATTCTTCTTCTTTTTTGTAATAAAAACTTTTTACTTTC
TTTTTAGTTGACAGATAATAATTGCGTATATTTATGGAGTACAATGTGATGTTTTGATATATGTATGCATGAGGGAATGATTAAATCAAG
CTAATTAACATATTCATCACTTCATCTACTCATCACTTTCTTGTGGTGAAAATGTTTCAGATATACTCTTTAGTAGTTTTCAGGTGTACA
GTCGCTGTGGTTTGAGTGCTTTTGTCTTCTCTAAATTTGATGTTGACACTTAGTGCCCAGTACAATGTTACTGGGAGGTGGAGCCTAATG
GGGATGTTTAATGGATTAATGCCATTATAAAAAGGGCTTGCAGGAATGGGTTCCTTCTCTTTTGCTTTTCTGCCATATGATGACAAAGTG
TTCCTCCTCTCTGGAGGATGCAGCAACAGGCACCATCTTTGAAGCAGAGAGACCAGGCCCTAACCTTCTGGTGCCTTGATCTTGGACTTC
TCAGCTTCCAGAACTGTGAGATAATAAATTTCTGTTCATTACAAATTACCCCATCTGTGGTATTCTGTTATAGCAACACAAAATGGACTA
AGACAACAGTATACTGTTATGAACTATGGTCACCATGCTGTGCACTAGATCACAAAAACTTATTTCTACTGTTTAACTGAAACTTTGTAC
ATTTTGACTAACATCTCCCTTTTTCCCATCATCCCATCCCATTCTTACTATCGTTGAAGATGGAGTATGCCAAGTAGTCCTGAGCCATGT
CCTCACCTCGGGGTGAGCACCTGTTGTTCCTGTGCCTGGAATGCTCTCCTAGACATTTGCGTGGCTAGCTCCCTCTTTTCATTCAGATCT
CAGCTCATTGTCATCTCAGAGAGGCCCTCCTTGCCCTCCTTCTACCTCCTGCCTTAGGTATACTCTGCCACCTTCTGTCATGGGCTGAAT
TGTGTCCCCCCTAAATCCATATGTTGACATCTTAACCCCTAGTACAGTAAGTCCTCACTTGATGCTATCAATAGGCTCTTGGAAATGTCG
GCTTTCAGTGAAAGGACATATAGCAGGTCCTTGAATAACATTGTGTTTTGTTCAACATCGTTGCCTTGTAACACTGATGAGCAAAACAGT
TGGTTCTCTAATATGTTGTTTTACTTAAAGCTACAGTTTCCAAGAACCTATCAATGATGTTGAGGACTGAATGTACCTCAGGTGTAATGT
ATTTGGAGATAGGGCCTTTTAAGAGGTAAAGTAAATGAGGTCATATGGGTAGGCTGTAATCCAATATGACTGGAATCCTTATAAGAAGAG
GAAATGAGGACACAGACACAGAGGGAAGATGACTATCTGCAAGTCAAGGAGAGAGGCCTCAGAAGAAACCAATGCTGCTGACACCACGAT
CTTGGACTTCTAGCCTCTAGCACTGTGAGGAAATAAATTTCTGTTGTTTAAGCCACCTAGTCTGTGATACTTTGCTACGGCAGGCCCTAG
CAAATGAATACACTTGTCTTGTCTTTCCCCCGCCCTGTGATATTTATCAGTGCCGGATATTACATATTTGTGTATCTATATGCTTATTTC
CCTGACTAAAATGGAAGCTCCATGAAGGCAGATTTCCTCTTGTTCACTGATGTGTCCCCAGCACCTGGAATAGTGCCTAGTGCATGCCAG
TGCTCAGACACTTGGACATTTGAATGACATATCCCCTCTGTCACTTCTCTCCGGGGCCCAAGGCCACCCTCCTAGGTTACCACAGTGGCT
TCCTAATGGGCCATACCCTCACTTGCTTTCCATCACCCCCTGAGACCTGGCCCCTGCATACCTCTCCAGCTTCACCCCTCACATATCTCC
CTAGCCAGACCTATAGTATGTTTTAAAAAAAAAGGAAATCGCACTCCTCTGGCCTCTTTACCTTGGCACACATTTTTCCATCACCTGACC
CCTGACCCACACTCCCTTTTCCTGTGTAATCCAATTATCTCTAGGCCTCCCGTGTTTCTGTTTGTCCTTCAATAGAAGGTTGTTTGTCTT
GTCTTTTATTGTATTTCTAGAACCAAGTGCAGAGACTGTACAAAGTGGACCTCAGCAAAGATTTACCGAATGAATAAATGAGTTCAGAAC

>6308_6308_2_ARHGEF3-ACP6_ARHGEF3_chr3_56916319_ENST00000496106_ACP6_chr1_147131890_ENST00000369238_length(amino acids)=403AA_BP=48
MQLGAGESGWMRSERPMVWCCLFVRSQRKRKQSTQDEDAVSLCSLDISVEWNPQLLEVPPQTQFDYTVTNLAGGPKPYSPYDSQYHETTL
KGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPNY
QSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQRAVDTSLYILPKEDRE
SLQMAVGPFLHILESNLLKAVDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQVP

--------------------------------------------------------------
>6308_6308_3_ARHGEF3-ACP6_ARHGEF3_chr3_56916320_ENST00000338458_ACP6_chr1_147131890_ENST00000369238_length(transcript)=6561nt_BP=302nt
AGCCCAGGGGAGCCGCCGCCGCAGCCGCCGCCGCCGCGGTGAGTTTTCCAGCCTGGAGAGGCCGAACCAGCGCGGGGGTCGAGGAGACCT
GAGCCTGCCATACTGAGTCTATGGACAGTTCCACAGCAATGAATCAATGCAGCTGTAGAGGAATGGAAGAAAACAAGGAAAGGCCTAAAC
GGCAGCGGCAAAACAACTTTCCCATGTTTCCCTCTCCTAAAGCCTGGAATTTCAGAGGGCGAAAACGGAAACAGAGCACCCAAGATGAAG
ATGCTGTTAGCCTTTGCAGTCTCGACATAAGTGTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCAGTTTGATTACACAG
TCACCAATCTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGGCATGTTTGCTGGGC
AGCTGACCAAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCCCTTTCTTTCACCAA
CCTTCAACCCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGCTGGGCTTTTCCAGT
GTCAGAAAGAAGGACCCATCATCATCCACACTGATGAAGCAGATTCAGAAGTCTTGTATCCCAACTACCAAAGCTGCTGGAGCCTGAGGC
AGAGAACCAGAGGCCGGAGGCAGACTGCCTCTTTACAGCCAGGAATCTCAGAGGATTTGAAAAAGGTGAAGGACAGGATGGGCATTGACA
GTAGTGATAAAGTGGACTTCTTCATCCTCCTGGACAACGTGGCTGCCGAGCAGGCACACAACCTCCCAAGCTGCCCCATGCTGAAGAGAT
TTGCAAGGATGATCGAACAGAGAGCTGTGGACACATCCTTGTACATACTGCCCAAGGAAGACAGGGAAAGTCTTCAGATGGCAGTAGGCC
CATTCCTCCACATCCTAGAGAGCAACCTGCTGAAAGCCGTGGACTCTGCCACTGCCCCCGACAAGATCAGAAAGCTGTATCTCTATGCGG
CTCATGATGTGACCTTCATACCGCTCTTAATGACCCTGGGGATTTTTGACCACAAATGGCCACCGTTTGCTGTTGACCTGACCATGGAAC
TTTACCAGCACCTGGAATCTAAGGAGTGGTTTGTGCAGCTCTATTACCACGGGAAGGAGCAGGTGCCGAGAGGTTGCCCTGATGGGCTCT
GCCCGCTGGACATGTTCTTGAATGCCATGTCAGTTTATACCTTAAGCCCAGAAAAATACCACGCACTCTGCTCTCAAACTCAGGTGATGG
AAGTTGGAAATGAAGAGTAACTGATTTATAAAAGCAGGATGTGTTGATTTTAAAATAAAGTGCCTTTATACAATGCCTCCTGCTTTGTGT
GTTTGGGAAGAGGAGAGAGCAAGGGGTAATGTACTTTAATATAATGTAAGGATATTTCCTTTCTGTGGGTTTACTAAGATTTCTTCCTGA
ACGGAAAAGGGGTATAATATTGAGACCAAAAGGATATTTCTCTATTTTGTGAGTTGGTTTCTAAGGTTAGAAGCATCTTTGTGTGACACG
GGCTGGGGACATCATGACCCTGTAGAATTGTGTCGGTTTTGGACTTTAGTTCTTTTCTCCTATATTAATTTCACATGTATTGAGCTACCT
ACTAAGTAGTGATCATTATAAAGGTGAAAACACTCTGCCCTCAAGTTGTTGCAGTCCAGTGGGAGAGGCAGCCGAGTAAATCAGTGATAC
AGTGCTGTATGTTTTATGCTGTAATAGGTATTTGAGGGGCTATTTGGGTATAGAGAAGAAACTTCCTGCTCACATGGCAGGGGATGTGGG
GAACAGTCAAGGAAGGCTTCTGAAAAAGTCCTGGCCTGATCTGAGTAGAGAAAGGTGGGTAGGAGTTAACCAGGAAAGCAAGGATGAAAG
CGTGTTGCGTTTAGATAAAGGATAGGCTTCAAGGTCAGGGAACGTTGCTGGGTGGTGAGATGGAACCCTGATGTGGAGGCTCAGCAGGAA
GAAGCAGGAAGGACACTGGGCCCCTGGTGGTTTTAGTTCCAGAAACAAATGTGGGCCCCAGGGCTCTGCAATGGTAAGGCTGGAACTACT
CAACATAAGAGCTCCACCTTTAACTGTGCCCCCTAAGAGTACCTGATGATCCCCCTATCTCCTTGTCAATGTTGCTGTTCTTCTCCAGAA
TCTATTTCAACCCTTCTCTGATTTCAAACCACCAGTCCCTTTACCTCTCAGAGAAAACAGCAACCACAAAAGCCTCTCCACTTCCTACTA
TCTTAATATTGACAACTTCCAGATCAGGGAGCTGAGATATCTCAAGCTCAGGTTTCTCTTCTGAGCTTCAGACGCTTTTATCCACTTGGA
TTTCACTGGCACAAAACTTTCCATGTTAGAATCAAACCCCCCTCCTCCCAGACCTGCTTCTCCCACACACTTCCCTATCTGAATGAAAGA
CACCTCCACTCTCCACCCAGTTGCCAAATCAGAAATCTGTCTTTGTTTTCTTTGTCTCACATTTTCCTATGTCTAATCAGTTAAGTTTTA
TCAATACTACCTGTTTATTTCTTTAATCTATTCACATATCTTTATCCTCAATCTTCAGCATCCCCTTCCCATCCTCAGTCTGCTGGTTAC
TGTATTTCCTATTTTACTAAGAATCTAAAAGAGATCAGAAGAAAACTTCCACATCCCCCAACACCCAACCACCAAATCTGCTAACCCAGT
TGCATTGGTGCTTTTATAGCCTTCCTTCCTCCCTCTTACTAAGAATGAACCAACACTATTCCTATCAAAGCCCAACCCTCTAGCTTTACA
TTGACTCCTAGTGTCTTTTTTCTGGATTGTCAATTTTTTTCCTGACCAATTATTCTATTAGCAATACAAATATGCTGTAAAATCTCTTAA
ACTTTTTTCTCTGCATCTTTGAACTGCTGTTCTCTTTTCCTTCTCCCCTTCATAGCAGAACTCCTCAAAAGAGTTGCTACCTCTAATTCT
TCCCTTCCAGTTCTCTCATGAACCAGCTACAATTAAGTATTCACCCCCACCACTCCATGGAAACTGCTCTTGTCAAAATCATCAATAGCC
TTTGTGTGGTGAATCCAATAGCCAGTTTTCATTCTTCTTACTAAGCTTCTCATCAGTATTCCTAGACTATTTCCTTCACTGGCTTCGACA
AATGCTTTCTTGGTTTTCCTCCAATTTCTCGACTTTGTTCCTGCTGAATCTACCTTTTTCTAATCCGTAAGTGTTGGGGTGTCCCAGGGC
TTACTCCTTGGACCTTTTTTCCACCTTTTCCCCTACACTCACCCACTAGGTGATCTCAAGAATTTCCAGTTTGAGGCCGGGCGCGGTGGC
TCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGGCCAGGAGTTCGAGACCAGCCTGGCCAACATGGCAAA
ACCCTGTCTCCACTAAACCTGCCTCTACTAAAAATACAAAAATTATTATATTTTTATAAAATTATTATAATTTTATAAAATTATTATATT
TATGGAGTACAATGTGATGTAATCCCAGCTACTCGGAAGGCTGTATGTGTCTATTTATGGAGTACAATGTGCCTGTAATCCCAGCTACTT
GGGAGGCTGAGGCAGGAGAATCACTTCAACCTAGGAGGCAGAGGTTGTGCTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACA
AGAGAGAAATAACATCTCAAAAAAAAAAAAAAAGAATTTCCAGTTTTAAATATTTACACAATGTCTCCTAAATTTATACCTTCAACCTAG
ACCTTTCCCTGTGAATCCCAGTCTCATTTCCAACAGTCTAATCAATGTCTCTATTTGGATGTTTAAGATATACAATAGGTATCAAACTTC
CCATTGTCCACAATAAACTCTCAATTTCCGTGCCTTTTCAAACTTACTCCTTCCACAGGCTTTCCCATCTAGGTAAATGACACCACCATT
CACCCTGTTGCTTTGGCCAAGAACTTTAGAACTGCCCTTGACTCCCCTCTTTTTCTCATATCCTACCTCTACTACATCAGTAACTCCTGT
TGTATCTCTCTTCAAACTATATCCAGAATTGACCATGTCCCAATACTTCCATTGCTACTGTCTTAGTCCCAGTGTCATCTTTTACCTGGA
TTATTGTAAAGGCCTCGTAACTAGTCTTCCTGTTTCTGCCCTTCCCTTCTCTGCCCATCTATTCTCAACACAGTGTTGCTTTTAAAACAA
AGTAAGATCGTGCCACTCTTCTGCTCTAAATTCCCCATTGGTTTCTCATCTCAAACTAAGGGCCAGTCATAATGCCCTCACGGTCCTATG
ACATCTCACTGCACCCCAGCCATACTCGCCATCTTACCATTCTTCTTCTTTTTTGTAATAAAAACTTTTTACTTTCTTTTTAGTTGACAG
ATAATAATTGCGTATATTTATGGAGTACAATGTGATGTTTTGATATATGTATGCATGAGGGAATGATTAAATCAAGCTAATTAACATATT
CATCACTTCATCTACTCATCACTTTCTTGTGGTGAAAATGTTTCAGATATACTCTTTAGTAGTTTTCAGGTGTACAGTCGCTGTGGTTTG
AGTGCTTTTGTCTTCTCTAAATTTGATGTTGACACTTAGTGCCCAGTACAATGTTACTGGGAGGTGGAGCCTAATGGGGATGTTTAATGG
ATTAATGCCATTATAAAAAGGGCTTGCAGGAATGGGTTCCTTCTCTTTTGCTTTTCTGCCATATGATGACAAAGTGTTCCTCCTCTCTGG
AGGATGCAGCAACAGGCACCATCTTTGAAGCAGAGAGACCAGGCCCTAACCTTCTGGTGCCTTGATCTTGGACTTCTCAGCTTCCAGAAC
TGTGAGATAATAAATTTCTGTTCATTACAAATTACCCCATCTGTGGTATTCTGTTATAGCAACACAAAATGGACTAAGACAACAGTATAC
TGTTATGAACTATGGTCACCATGCTGTGCACTAGATCACAAAAACTTATTTCTACTGTTTAACTGAAACTTTGTACATTTTGACTAACAT
CTCCCTTTTTCCCATCATCCCATCCCATTCTTACTATCGTTGAAGATGGAGTATGCCAAGTAGTCCTGAGCCATGTCCTCACCTCGGGGT
GAGCACCTGTTGTTCCTGTGCCTGGAATGCTCTCCTAGACATTTGCGTGGCTAGCTCCCTCTTTTCATTCAGATCTCAGCTCATTGTCAT
CTCAGAGAGGCCCTCCTTGCCCTCCTTCTACCTCCTGCCTTAGGTATACTCTGCCACCTTCTGTCATGGGCTGAATTGTGTCCCCCCTAA
ATCCATATGTTGACATCTTAACCCCTAGTACAGTAAGTCCTCACTTGATGCTATCAATAGGCTCTTGGAAATGTCGGCTTTCAGTGAAAG
GACATATAGCAGGTCCTTGAATAACATTGTGTTTTGTTCAACATCGTTGCCTTGTAACACTGATGAGCAAAACAGTTGGTTCTCTAATAT
GTTGTTTTACTTAAAGCTACAGTTTCCAAGAACCTATCAATGATGTTGAGGACTGAATGTACCTCAGGTGTAATGTATTTGGAGATAGGG
CCTTTTAAGAGGTAAAGTAAATGAGGTCATATGGGTAGGCTGTAATCCAATATGACTGGAATCCTTATAAGAAGAGGAAATGAGGACACA
GACACAGAGGGAAGATGACTATCTGCAAGTCAAGGAGAGAGGCCTCAGAAGAAACCAATGCTGCTGACACCACGATCTTGGACTTCTAGC
CTCTAGCACTGTGAGGAAATAAATTTCTGTTGTTTAAGCCACCTAGTCTGTGATACTTTGCTACGGCAGGCCCTAGCAAATGAATACACT
TGTCTTGTCTTTCCCCCGCCCTGTGATATTTATCAGTGCCGGATATTACATATTTGTGTATCTATATGCTTATTTCCCTGACTAAAATGG
AAGCTCCATGAAGGCAGATTTCCTCTTGTTCACTGATGTGTCCCCAGCACCTGGAATAGTGCCTAGTGCATGCCAGTGCTCAGACACTTG
GACATTTGAATGACATATCCCCTCTGTCACTTCTCTCCGGGGCCCAAGGCCACCCTCCTAGGTTACCACAGTGGCTTCCTAATGGGCCAT
ACCCTCACTTGCTTTCCATCACCCCCTGAGACCTGGCCCCTGCATACCTCTCCAGCTTCACCCCTCACATATCTCCCTAGCCAGACCTAT
AGTATGTTTTAAAAAAAAAGGAAATCGCACTCCTCTGGCCTCTTTACCTTGGCACACATTTTTCCATCACCTGACCCCTGACCCACACTC
CCTTTTCCTGTGTAATCCAATTATCTCTAGGCCTCCCGTGTTTCTGTTTGTCCTTCAATAGAAGGTTGTTTGTCTTGTCTTTTATTGTAT

>6308_6308_3_ARHGEF3-ACP6_ARHGEF3_chr3_56916320_ENST00000338458_ACP6_chr1_147131890_ENST00000369238_length(amino acids)=419AA_BP=64
MDSSTAMNQCSCRGMEENKERPKRQRQNNFPMFPSPKAWNFRGRKRKQSTQDEDAVSLCSLDISVEWNPQLLEVPPQTQFDYTVTNLAGG
PKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPI
IIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQ
RAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAVDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLES

--------------------------------------------------------------
>6308_6308_4_ARHGEF3-ACP6_ARHGEF3_chr3_56916320_ENST00000496106_ACP6_chr1_147131890_ENST00000369238_length(transcript)=6485nt_BP=226nt
ATGCAGCCCAAGTGGCGGGGAGGAGTTCCTTCAGGGAAACTATGCTCAGCCCTGTTCAGAGAATCCTGTGCACAGGGCTCCACTGCAGTT
AGGAGCCGGTGAGTCCGGGTGGATGAGGTCAGAGCGCCCCATGGTGTGGTGCTGCCTCTTTGTCCGTTCGCAGCGAAAACGGAAACAGAG
CACCCAAGATGAAGATGCTGTTAGCCTTTGCAGTCTCGACATAAGTGTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCA
GTTTGATTACACAGTCACCAATCTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGG
CATGTTTGCTGGGCAGCTGACCAAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCC
CTTTCTTTCACCAACCTTCAACCCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGC
TGGGCTTTTCCAGTGTCAGAAAGAAGGACCCATCATCATCCACACTGATGAAGCAGATTCAGAAGTCTTGTATCCCAACTACCAAAGCTG
CTGGAGCCTGAGGCAGAGAACCAGAGGCCGGAGGCAGACTGCCTCTTTACAGCCAGGAATCTCAGAGGATTTGAAAAAGGTGAAGGACAG
GATGGGCATTGACAGTAGTGATAAAGTGGACTTCTTCATCCTCCTGGACAACGTGGCTGCCGAGCAGGCACACAACCTCCCAAGCTGCCC
CATGCTGAAGAGATTTGCAAGGATGATCGAACAGAGAGCTGTGGACACATCCTTGTACATACTGCCCAAGGAAGACAGGGAAAGTCTTCA
GATGGCAGTAGGCCCATTCCTCCACATCCTAGAGAGCAACCTGCTGAAAGCCGTGGACTCTGCCACTGCCCCCGACAAGATCAGAAAGCT
GTATCTCTATGCGGCTCATGATGTGACCTTCATACCGCTCTTAATGACCCTGGGGATTTTTGACCACAAATGGCCACCGTTTGCTGTTGA
CCTGACCATGGAACTTTACCAGCACCTGGAATCTAAGGAGTGGTTTGTGCAGCTCTATTACCACGGGAAGGAGCAGGTGCCGAGAGGTTG
CCCTGATGGGCTCTGCCCGCTGGACATGTTCTTGAATGCCATGTCAGTTTATACCTTAAGCCCAGAAAAATACCACGCACTCTGCTCTCA
AACTCAGGTGATGGAAGTTGGAAATGAAGAGTAACTGATTTATAAAAGCAGGATGTGTTGATTTTAAAATAAAGTGCCTTTATACAATGC
CTCCTGCTTTGTGTGTTTGGGAAGAGGAGAGAGCAAGGGGTAATGTACTTTAATATAATGTAAGGATATTTCCTTTCTGTGGGTTTACTA
AGATTTCTTCCTGAACGGAAAAGGGGTATAATATTGAGACCAAAAGGATATTTCTCTATTTTGTGAGTTGGTTTCTAAGGTTAGAAGCAT
CTTTGTGTGACACGGGCTGGGGACATCATGACCCTGTAGAATTGTGTCGGTTTTGGACTTTAGTTCTTTTCTCCTATATTAATTTCACAT
GTATTGAGCTACCTACTAAGTAGTGATCATTATAAAGGTGAAAACACTCTGCCCTCAAGTTGTTGCAGTCCAGTGGGAGAGGCAGCCGAG
TAAATCAGTGATACAGTGCTGTATGTTTTATGCTGTAATAGGTATTTGAGGGGCTATTTGGGTATAGAGAAGAAACTTCCTGCTCACATG
GCAGGGGATGTGGGGAACAGTCAAGGAAGGCTTCTGAAAAAGTCCTGGCCTGATCTGAGTAGAGAAAGGTGGGTAGGAGTTAACCAGGAA
AGCAAGGATGAAAGCGTGTTGCGTTTAGATAAAGGATAGGCTTCAAGGTCAGGGAACGTTGCTGGGTGGTGAGATGGAACCCTGATGTGG
AGGCTCAGCAGGAAGAAGCAGGAAGGACACTGGGCCCCTGGTGGTTTTAGTTCCAGAAACAAATGTGGGCCCCAGGGCTCTGCAATGGTA
AGGCTGGAACTACTCAACATAAGAGCTCCACCTTTAACTGTGCCCCCTAAGAGTACCTGATGATCCCCCTATCTCCTTGTCAATGTTGCT
GTTCTTCTCCAGAATCTATTTCAACCCTTCTCTGATTTCAAACCACCAGTCCCTTTACCTCTCAGAGAAAACAGCAACCACAAAAGCCTC
TCCACTTCCTACTATCTTAATATTGACAACTTCCAGATCAGGGAGCTGAGATATCTCAAGCTCAGGTTTCTCTTCTGAGCTTCAGACGCT
TTTATCCACTTGGATTTCACTGGCACAAAACTTTCCATGTTAGAATCAAACCCCCCTCCTCCCAGACCTGCTTCTCCCACACACTTCCCT
ATCTGAATGAAAGACACCTCCACTCTCCACCCAGTTGCCAAATCAGAAATCTGTCTTTGTTTTCTTTGTCTCACATTTTCCTATGTCTAA
TCAGTTAAGTTTTATCAATACTACCTGTTTATTTCTTTAATCTATTCACATATCTTTATCCTCAATCTTCAGCATCCCCTTCCCATCCTC
AGTCTGCTGGTTACTGTATTTCCTATTTTACTAAGAATCTAAAAGAGATCAGAAGAAAACTTCCACATCCCCCAACACCCAACCACCAAA
TCTGCTAACCCAGTTGCATTGGTGCTTTTATAGCCTTCCTTCCTCCCTCTTACTAAGAATGAACCAACACTATTCCTATCAAAGCCCAAC
CCTCTAGCTTTACATTGACTCCTAGTGTCTTTTTTCTGGATTGTCAATTTTTTTCCTGACCAATTATTCTATTAGCAATACAAATATGCT
GTAAAATCTCTTAAACTTTTTTCTCTGCATCTTTGAACTGCTGTTCTCTTTTCCTTCTCCCCTTCATAGCAGAACTCCTCAAAAGAGTTG
CTACCTCTAATTCTTCCCTTCCAGTTCTCTCATGAACCAGCTACAATTAAGTATTCACCCCCACCACTCCATGGAAACTGCTCTTGTCAA
AATCATCAATAGCCTTTGTGTGGTGAATCCAATAGCCAGTTTTCATTCTTCTTACTAAGCTTCTCATCAGTATTCCTAGACTATTTCCTT
CACTGGCTTCGACAAATGCTTTCTTGGTTTTCCTCCAATTTCTCGACTTTGTTCCTGCTGAATCTACCTTTTTCTAATCCGTAAGTGTTG
GGGTGTCCCAGGGCTTACTCCTTGGACCTTTTTTCCACCTTTTCCCCTACACTCACCCACTAGGTGATCTCAAGAATTTCCAGTTTGAGG
CCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGGCCAGGAGTTCGAGACCAGCCTG
GCCAACATGGCAAAACCCTGTCTCCACTAAACCTGCCTCTACTAAAAATACAAAAATTATTATATTTTTATAAAATTATTATAATTTTAT
AAAATTATTATATTTATGGAGTACAATGTGATGTAATCCCAGCTACTCGGAAGGCTGTATGTGTCTATTTATGGAGTACAATGTGCCTGT
AATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTCAACCTAGGAGGCAGAGGTTGTGCTGAGCCAAGATCGTGCCATTGCACTC
CAGCCTGGGCAACAAGAGAGAAATAACATCTCAAAAAAAAAAAAAAAGAATTTCCAGTTTTAAATATTTACACAATGTCTCCTAAATTTA
TACCTTCAACCTAGACCTTTCCCTGTGAATCCCAGTCTCATTTCCAACAGTCTAATCAATGTCTCTATTTGGATGTTTAAGATATACAAT
AGGTATCAAACTTCCCATTGTCCACAATAAACTCTCAATTTCCGTGCCTTTTCAAACTTACTCCTTCCACAGGCTTTCCCATCTAGGTAA
ATGACACCACCATTCACCCTGTTGCTTTGGCCAAGAACTTTAGAACTGCCCTTGACTCCCCTCTTTTTCTCATATCCTACCTCTACTACA
TCAGTAACTCCTGTTGTATCTCTCTTCAAACTATATCCAGAATTGACCATGTCCCAATACTTCCATTGCTACTGTCTTAGTCCCAGTGTC
ATCTTTTACCTGGATTATTGTAAAGGCCTCGTAACTAGTCTTCCTGTTTCTGCCCTTCCCTTCTCTGCCCATCTATTCTCAACACAGTGT
TGCTTTTAAAACAAAGTAAGATCGTGCCACTCTTCTGCTCTAAATTCCCCATTGGTTTCTCATCTCAAACTAAGGGCCAGTCATAATGCC
CTCACGGTCCTATGACATCTCACTGCACCCCAGCCATACTCGCCATCTTACCATTCTTCTTCTTTTTTGTAATAAAAACTTTTTACTTTC
TTTTTAGTTGACAGATAATAATTGCGTATATTTATGGAGTACAATGTGATGTTTTGATATATGTATGCATGAGGGAATGATTAAATCAAG
CTAATTAACATATTCATCACTTCATCTACTCATCACTTTCTTGTGGTGAAAATGTTTCAGATATACTCTTTAGTAGTTTTCAGGTGTACA
GTCGCTGTGGTTTGAGTGCTTTTGTCTTCTCTAAATTTGATGTTGACACTTAGTGCCCAGTACAATGTTACTGGGAGGTGGAGCCTAATG
GGGATGTTTAATGGATTAATGCCATTATAAAAAGGGCTTGCAGGAATGGGTTCCTTCTCTTTTGCTTTTCTGCCATATGATGACAAAGTG
TTCCTCCTCTCTGGAGGATGCAGCAACAGGCACCATCTTTGAAGCAGAGAGACCAGGCCCTAACCTTCTGGTGCCTTGATCTTGGACTTC
TCAGCTTCCAGAACTGTGAGATAATAAATTTCTGTTCATTACAAATTACCCCATCTGTGGTATTCTGTTATAGCAACACAAAATGGACTA
AGACAACAGTATACTGTTATGAACTATGGTCACCATGCTGTGCACTAGATCACAAAAACTTATTTCTACTGTTTAACTGAAACTTTGTAC
ATTTTGACTAACATCTCCCTTTTTCCCATCATCCCATCCCATTCTTACTATCGTTGAAGATGGAGTATGCCAAGTAGTCCTGAGCCATGT
CCTCACCTCGGGGTGAGCACCTGTTGTTCCTGTGCCTGGAATGCTCTCCTAGACATTTGCGTGGCTAGCTCCCTCTTTTCATTCAGATCT
CAGCTCATTGTCATCTCAGAGAGGCCCTCCTTGCCCTCCTTCTACCTCCTGCCTTAGGTATACTCTGCCACCTTCTGTCATGGGCTGAAT
TGTGTCCCCCCTAAATCCATATGTTGACATCTTAACCCCTAGTACAGTAAGTCCTCACTTGATGCTATCAATAGGCTCTTGGAAATGTCG
GCTTTCAGTGAAAGGACATATAGCAGGTCCTTGAATAACATTGTGTTTTGTTCAACATCGTTGCCTTGTAACACTGATGAGCAAAACAGT
TGGTTCTCTAATATGTTGTTTTACTTAAAGCTACAGTTTCCAAGAACCTATCAATGATGTTGAGGACTGAATGTACCTCAGGTGTAATGT
ATTTGGAGATAGGGCCTTTTAAGAGGTAAAGTAAATGAGGTCATATGGGTAGGCTGTAATCCAATATGACTGGAATCCTTATAAGAAGAG
GAAATGAGGACACAGACACAGAGGGAAGATGACTATCTGCAAGTCAAGGAGAGAGGCCTCAGAAGAAACCAATGCTGCTGACACCACGAT
CTTGGACTTCTAGCCTCTAGCACTGTGAGGAAATAAATTTCTGTTGTTTAAGCCACCTAGTCTGTGATACTTTGCTACGGCAGGCCCTAG
CAAATGAATACACTTGTCTTGTCTTTCCCCCGCCCTGTGATATTTATCAGTGCCGGATATTACATATTTGTGTATCTATATGCTTATTTC
CCTGACTAAAATGGAAGCTCCATGAAGGCAGATTTCCTCTTGTTCACTGATGTGTCCCCAGCACCTGGAATAGTGCCTAGTGCATGCCAG
TGCTCAGACACTTGGACATTTGAATGACATATCCCCTCTGTCACTTCTCTCCGGGGCCCAAGGCCACCCTCCTAGGTTACCACAGTGGCT
TCCTAATGGGCCATACCCTCACTTGCTTTCCATCACCCCCTGAGACCTGGCCCCTGCATACCTCTCCAGCTTCACCCCTCACATATCTCC
CTAGCCAGACCTATAGTATGTTTTAAAAAAAAAGGAAATCGCACTCCTCTGGCCTCTTTACCTTGGCACACATTTTTCCATCACCTGACC
CCTGACCCACACTCCCTTTTCCTGTGTAATCCAATTATCTCTAGGCCTCCCGTGTTTCTGTTTGTCCTTCAATAGAAGGTTGTTTGTCTT
GTCTTTTATTGTATTTCTAGAACCAAGTGCAGAGACTGTACAAAGTGGACCTCAGCAAAGATTTACCGAATGAATAAATGAGTTCAGAAC

>6308_6308_4_ARHGEF3-ACP6_ARHGEF3_chr3_56916320_ENST00000496106_ACP6_chr1_147131890_ENST00000369238_length(amino acids)=403AA_BP=48
MQLGAGESGWMRSERPMVWCCLFVRSQRKRKQSTQDEDAVSLCSLDISVEWNPQLLEVPPQTQFDYTVTNLAGGPKPYSPYDSQYHETTL
KGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPNY
QSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQRAVDTSLYILPKEDRE
SLQMAVGPFLHILESNLLKAVDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQVP

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Fusion Gene PPI Analysis for ARHGEF3-ACP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGEF3-ACP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGEF3-ACP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource