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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ATP5B-IVNS1ABP (FusionGDB2 ID:HG506TG10625)

Fusion Gene Summary for ATP5B-IVNS1ABP

Fusion gene summary

Fusion gene information	Fusion gene name: ATP5B-IVNS1ABP
	Fusion gene ID: hg506tg10625
		Hgene	Tgene
	Gene symbol	ATP5B	IVNS1ABP
	Gene ID	506	10625
	Gene name	ATP synthase F1 subunit beta	influenza virus NS1A binding protein
	Synonyms	ATP5B\|ATPMB\|ATPSB\|HEL-S-271	ARA3\|FLARA3\|HSPC068\|KLHL39\|ND1\|NS-1\|NS1-BP\|NS1BP
	Cytomap	('ATP5B')('IVNS1ABP') 12q13.3	1q25.3
	Type of gene	protein-coding	protein-coding
	Description	ATP synthase subunit beta, mitochondrialATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptideepididymis secretory protein Li 271mitochondrial ATP synthase beta subunitmitochondrial ATP synthetase, beta subunit	influenza virus NS1A-binding proteinNCX downstream gene 1NS1-binding proteinaryl hydrocarbon receptor-associated 3aryl hydrocarbon receptor-associated protein 3kelch-like family member 39kelch-like protein 39
	Modification date	20200327	20200320
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000262030, ENST00000552919, ENST00000550162,
Fusion gene scores	* DoF score	17 X 19 X 7=2261	17 X 9 X 9=1377
	# samples	22	18
	** MAII score	log2(22/2261*10)=-3.36138556322687 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1377*10)=-2.93545974780529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ATP5B [Title/Abstract] AND IVNS1ABP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ATP5B(57037186)-IVNS1ABP(185274775), # samples:1
Anticipated loss of major functional domain due to fusion event.	ATP5B-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP5B-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ATP5B	GO:0042776	mitochondrial ATP synthesis coupled proton transport	12110673

Fusion gene breakpoints across ATP5B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IVNS1ABP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-F1-A72C	ATP5B	chr12	57037186	-	IVNS1ABP	chr1	185274775	-

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Fusion Gene ORF analysis for ATP5B-IVNS1ABP

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000262030	ENST00000392007	ATP5B	chr12	57037186	-	IVNS1ABP	chr1	185274775	-
5CDS-5UTR	ENST00000262030	ENST00000459929	ATP5B	chr12	57037186	-	IVNS1ABP	chr1	185274775	-
5CDS-5UTR	ENST00000552919	ENST00000392007	ATP5B	chr12	57037186	-	IVNS1ABP	chr1	185274775	-
5CDS-5UTR	ENST00000552919	ENST00000459929	ATP5B	chr12	57037186	-	IVNS1ABP	chr1	185274775	-
5CDS-intron	ENST00000262030	ENST00000367497	ATP5B	chr12	57037186	-	IVNS1ABP	chr1	185274775	-
5CDS-intron	ENST00000552919	ENST00000367497	ATP5B	chr12	57037186	-	IVNS1ABP	chr1	185274775	-
In-frame	ENST00000262030	ENST00000367498	ATP5B	chr12	57037186	-	IVNS1ABP	chr1	185274775	-
In-frame	ENST00000552919	ENST00000367498	ATP5B	chr12	57037186	-	IVNS1ABP	chr1	185274775	-
intron-3CDS	ENST00000550162	ENST00000367498	ATP5B	chr12	57037186	-	IVNS1ABP	chr1	185274775	-
intron-5UTR	ENST00000550162	ENST00000392007	ATP5B	chr12	57037186	-	IVNS1ABP	chr1	185274775	-
intron-5UTR	ENST00000550162	ENST00000459929	ATP5B	chr12	57037186	-	IVNS1ABP	chr1	185274775	-
intron-intron	ENST00000550162	ENST00000367497	ATP5B	chr12	57037186	-	IVNS1ABP	chr1	185274775	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000262030	ATP5B	chr12	57037186	-	ENST00000367498	IVNS1ABP	chr1	185274775	-	3762	843	51	2114	687
ENST00000552919	ATP5B	chr12	57037186	-	ENST00000367498	IVNS1ABP	chr1	185274775	-	3721	802	10	2073	687

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262030	ENST00000367498	ATP5B	chr12	57037186	-	IVNS1ABP	chr1	185274775	-	0.000439679	0.9995603
ENST00000552919	ENST00000367498	ATP5B	chr12	57037186	-	IVNS1ABP	chr1	185274775	-	0.000382122	0.9996178

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Fusion Genomic Features for ATP5B-IVNS1ABP

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for ATP5B-IVNS1ABP

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:57037186/chr1:185274775)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP5B

chr12:57037186

chr1:185274775

ENST00000262030

207_214

264

530.0

Nucleotide binding

ATP

Tgene

IVNS1ABP

chr12:57037186

chr1:185274775

ENST00000367498

369_415

219

643.0

Repeat

Note=Kelch 1

Tgene

IVNS1ABP

chr12:57037186

chr1:185274775

ENST00000367498

416_463

219

643.0

Repeat

Note=Kelch 2

Tgene

IVNS1ABP

chr12:57037186

chr1:185274775

ENST00000367498

465_512

219

643.0

Repeat

Note=Kelch 3

Tgene

IVNS1ABP

chr12:57037186

chr1:185274775

ENST00000367498

513_559

219

643.0

Repeat

Note=Kelch 4

Tgene

IVNS1ABP

chr12:57037186

chr1:185274775

ENST00000367498

560_606

219

643.0

Repeat

Note=Kelch 5

Tgene

IVNS1ABP

chr12:57037186

chr1:185274775

ENST00000367498

608_642

219

643.0

Repeat

Note=Kelch 6

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

IVNS1ABP

chr12:57037186

chr1:185274775

ENST00000367498

134_233

219

643.0

Domain

Note=BACK

Tgene

IVNS1ABP

chr12:57037186

chr1:185274775

ENST00000367498

32_99

219

643.0

Domain

BTB

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Fusion Gene Sequence for ATP5B-IVNS1ABP

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>7933_7933_1_ATP5B-IVNS1ABP_ATP5B_chr12_57037186_ENST00000262030_IVNS1ABP_chr1_185274775_ENST00000367498_length(transcript)=3762nt_BP=843nt
GAGCAGGCGGCTGCGGTTGCTGCAGCCTTCAGTCTCCACCCGGACTACGCCATGTTGGGGTTTGTGGGTCGGGTGGCCGCTGCTCCGGCC
TCCGGGGCCTTGCGGAGACTCACCCCTTCAGCGTCGCTGCCCCCAGCTCAGCTCTTACTGCGGGCCGCTCCGACGGCGGTCCATCCTGTC
AGGGACTATGCGGCGCAAACATCTCCTTCGCCAAAAGCAGGCGCCGCCACCGGGCGCATCGTGGCGGTCATTGGCGCAGTGGTGGACGTC
CAGTTTGATGAGGGACTACCACCAATTCTAAATGCCCTGGAAGTGCAAGGCAGGGAGACCAGACTGGTTTTGGAGGTGGCCCAGCATTTG
GGTGAGAGCACAGTAAGGACTATTGCTATGGATGGTACAGAAGGCTTGGTTAGAGGCCAGAAAGTACTGGATTCTGGTGCACCAATCAAA
ATTCCTGTTGGTCCTGAGACTTTGGGCAGAATCATGAATGTCATTGGAGAACCTATTGATGAAAGAGGTCCCATCAAAACCAAACAATTT
GCTCCCATTCATGCTGAGGCTCCAGAGTTCATGGAAATGAGTGTTGAGCAGGAAATTCTGGTGACTGGTATCAAGGTTGTCGATCTGCTA
GCTCCCTATGCCAAGGGTGGCAAAATTGGGCTTTTTGGTGGTGCTGGAGTTGGCAAGACTGTACTGATCATGGAGTTAATCAACAATGTC
GCCAAAGCCCATGGTGGTTACTCTGTGTTTGCTGGTGTTGGTGAGAGGACCCGTGAAGGCAATGATTTATACCATGAAATGATTGAATCT
GGTGTTATCAACTTAAAAGATGCCACCTCTAAGGTTCAAACCTTGTACTACTCAGCTGATCACAAGCTGCTTGATGGGAACCTACTAGAT
GGACAGGCTGAGGTGTTTGGCAGTGATGATGACCACATTCAGTTTGTGCAGAAAAAGCCACCACGTGAGAATGGCCATAAGCAGATAAGT
AGCAGTTCAACTGGATGTCTCTCTTCTCCAAATGCTACAGTACAAAGCCCTAAGCATGAGTGGAAAATCGTTGCTTCAGAAAAGACTTCA
AATAACACTTACTTGTGCCTGGCTGTGCTGGATGGTATATTCTGTGTCATTTTTCTTCATGGGAGAAACAGCCCACAGAGCTCACCAACA
AGTACTCCAAAACTAAGTAAGAGTTTAAGCTTTGAGATGCAACAAGATGAGCTAATCGAAAAGCCCATGTCTCCTATGCAGTACGCACGA
TCTGGTCTGGGAACAGCAGAGATGAATGGCAAACTCATAGCTGCAGGTGGCTATAACAGAGAGGAATGTCTTCGAACAGTCGAATGCTAT
AATCCACATACAGATCACTGGTCCTTTCTTGCTCCCATGAGAACACCAAGAGCCCGATTTCAAATGGCTGTACTCATGGGCCAGCTCTAT
GTGGTAGGTGGATCAAATGGCCACTCAGATGACCTGAGTTGTGGAGAGATGTATGATTCAAACATAGATGACTGGATTCCTGTTCCAGAA
TTGAGAACTAACCGTTGTAATGCAGGAGTGTGTGCTCTGAATGGAAAGTTATACATCGTTGGTGGCTCTGATCCATATGGTCAAAAAGGA
CTGAAAAATTGTGATGTATTTGATCCTGTAACAAAGTTGTGGACAAGCTGTGCCCCTCTTAACATTCGGAGACACCAGTCTGCAGTCTGT
GAGCTTGGTGGTTATTTGTACATAATCGGAGGTGCAGAATCTTGGAATTGTCTGAACACAGTAGAACGATACAATCCTGAAAATAATACC
TGGACTTTAATTGCACCCATGAATGTGGCTAGGCGAGGAGCTGGAGTGGCTGTTCTTAATGGAAAACTGTTTGTATGTGGTGGCTTTGAT
GGTTCTCATGCCATCAGTTGTGTGGAAATGTATGATCCAACTAGAAATGAATGGAAGATGATGGGAAATATGACTTCACCAAGGAGCAAT
GCTGGGATTGCAACTGTAGGGAACACCATTTATGCAGTGGGAGGATTCGATGGCAATGAATTTCTGAATACGGTGGAAGTCTATAACCTT
GAGTCAAATGAATGGAGCCCCTATACAAAGATTTTCCAGTTTTAACAAATTTAAGACCCTCTCAAACTAACAGGCTTAGTGATGTAATTA
TGGTTAGTAGAGGTACACTTGTGAATAAAGAGGGTGGGTGGGTATAGATGTTGCTAACAGCAACACAAAGCTTTTGCATATTGCATACTA
TTAAACATGCTGTACATACTTTTTGGGTTTATTTGGAAAGGAATGCAAAGATGAAGGTCTGTTTTGTGTACTTTTAAGACTTTGGTTATT
TTACTTTTTGGAAAAGAATAAACCAAGAATTGATTGGGCACATCATTTCAAGAAGTCCCCTCTCCTCCACATTTGTTTTGCCAATTTGCA
CATTAAATGACTCTTCCCTCAAATGTGTACTATGGGGTAAAAGGGGTAGGGTTTAAAGATGTAGACAGTTGGGTTTTTTAAGGGCCCTTT
TTCAATAACTGGAACACTCTATAACAAAGGATACTTATTTAAATAGATGACATTGACTATTTTTGTTTTTATTAAAAGGAAGCTTACATG
CCTACCAATATTTAATCTTTTATGATTGCCTTTTTATAACTTTTTATATTCTCAGCAGAGTGCTTTACCAATTGAAGTAAAATGTGGCAG
GCTGGAGTTATTGAAGCAGAGTGGCAGTCTTCAGTTTGCAGAGTAGGGGTCTGTCTTTTAAACTCTGAGTGCAAACTTCAGAGTTCTTGC
CTTGGCTGCAGTTTTTTTCCTTCAAGAATGCAGTACTAACATTTATTTGAGTGGAGTTACTGAACAGTAACATAGCTGTGATTTTTGGTA
TTTGAAACACTGGTTTTAAATATTTTGACTTGTTGAGGGTATGTTTTATATAGCAAGACATTATATAGCAGTAAAAAATGGTGTTTTATC
TTCTATATAATTCCTGTTTTTATTATTAACAAAACAGTCCTAAATAGCAGCCCTCAATTGTGAAAAAATTTACTTTAAACTACATTAGGT
TGTGAATGCAGGTTTTATCAGAACTATGTTTTTGTTCAGTTTATCTGTTCATATGGATAAATATTGGTTGGGATGACTTGGTGTCTAATG
TGTAGTGCTACACACCTAACTTATGGGGCCAAAATAGCATGTCCTAATGCTTGCTGCTGATTTAAACACATTAAAGGTACTTTGCAGGAA
ATCCTTGCACCATGGGATTAATATCCAATTGCTGCTTGTACACTCATTCATTACTAAAAGTTTTGAGAAATTTTTTTTTCCAGTAATGAG
CTTAAGAAATTTGTGGAAAATAACTCACCTGGCATCTTACATCTGAAATAAGGAATGATATAAGGTTTTTTTTTCTCACAGAAGATGAAG
CACACAGGAACCTAATGGGCCAACTGGGATGAGGTGACTATTCTGAGATGACTATTCAGTGGCTAACTTGGGTTAGGAAGAAAATAATTA
GGTATTTTCTCCAAATGTTCACTGGTACTCTGCCACTTTATTTCTCTCATCTGTTACACAAAGAACCACCAGGAAAGCAAATCAGTTTGG
TTGGTAACTCTGTAATTCCTAACTATCACTGGTTTGGTTCTGGACTAAAACTACATTGACAGATTGAATTTGCCTAATATGATGACTGTT
TTTAATATGGATCTGTATGTGTTCTATTCAGCACAAGGAAATAAAATTTTAGTTGAGGATTCAGCACTAAAA

>7933_7933_1_ATP5B-IVNS1ABP_ATP5B_chr12_57037186_ENST00000262030_IVNS1ABP_chr1_185274775_ENST00000367498_length(amino acids)=687AA_BP=264
MLGFVGRVAAAPASGALRRLTPSASLPPAQLLLRAAPTAVHPVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILNALEVQG
RETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQ
EILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVQTLYY
SADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVI
FLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPR
ARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSC
APLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNE
WKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKIFQF

--------------------------------------------------------------
>7933_7933_2_ATP5B-IVNS1ABP_ATP5B_chr12_57037186_ENST00000552919_IVNS1ABP_chr1_185274775_ENST00000367498_length(transcript)=3721nt_BP=802nt
GGACTACGCCATGTTGGGGTTTGTGGGTCGGGTGGCCGCTGCTCCGGCCTCCGGGGCCTTGCGGAGACTCACCCCTTCAGCGTCGCTGCC
CCCAGCTCAGCTCTTACTGCGGGCCGCTCCGACGGCGGTCCATCCTGTCAGGGACTATGCGGCGCAAACATCTCCTTCGCCAAAAGCAGG
CGCCGCCACCGGGCGCATCGTGGCGGTCATTGGCGCAGTGGTGGACGTCCAGTTTGATGAGGGACTACCACCAATTCTAAATGCCCTGGA
AGTGCAAGGCAGGGAGACCAGACTGGTTTTGGAGGTGGCCCAGCATTTGGGTGAGAGCACAGTAAGGACTATTGCTATGGATGGTACAGA
AGGCTTGGTTAGAGGCCAGAAAGTACTGGATTCTGGTGCACCAATCAAAATTCCTGTTGGTCCTGAGACTTTGGGCAGAATCATGAATGT
CATTGGAGAACCTATTGATGAAAGAGGTCCCATCAAAACCAAACAATTTGCTCCCATTCATGCTGAGGCTCCAGAGTTCATGGAAATGAG
TGTTGAGCAGGAAATTCTGGTGACTGGTATCAAGGTTGTCGATCTGCTAGCTCCCTATGCCAAGGGTGGCAAAATTGGGCTTTTTGGTGG
TGCTGGAGTTGGCAAGACTGTACTGATCATGGAGTTAATCAACAATGTCGCCAAAGCCCATGGTGGTTACTCTGTGTTTGCTGGTGTTGG
TGAGAGGACCCGTGAAGGCAATGATTTATACCATGAAATGATTGAATCTGGTGTTATCAACTTAAAAGATGCCACCTCTAAGGTTCAAAC
CTTGTACTACTCAGCTGATCACAAGCTGCTTGATGGGAACCTACTAGATGGACAGGCTGAGGTGTTTGGCAGTGATGATGACCACATTCA
GTTTGTGCAGAAAAAGCCACCACGTGAGAATGGCCATAAGCAGATAAGTAGCAGTTCAACTGGATGTCTCTCTTCTCCAAATGCTACAGT
ACAAAGCCCTAAGCATGAGTGGAAAATCGTTGCTTCAGAAAAGACTTCAAATAACACTTACTTGTGCCTGGCTGTGCTGGATGGTATATT
CTGTGTCATTTTTCTTCATGGGAGAAACAGCCCACAGAGCTCACCAACAAGTACTCCAAAACTAAGTAAGAGTTTAAGCTTTGAGATGCA
ACAAGATGAGCTAATCGAAAAGCCCATGTCTCCTATGCAGTACGCACGATCTGGTCTGGGAACAGCAGAGATGAATGGCAAACTCATAGC
TGCAGGTGGCTATAACAGAGAGGAATGTCTTCGAACAGTCGAATGCTATAATCCACATACAGATCACTGGTCCTTTCTTGCTCCCATGAG
AACACCAAGAGCCCGATTTCAAATGGCTGTACTCATGGGCCAGCTCTATGTGGTAGGTGGATCAAATGGCCACTCAGATGACCTGAGTTG
TGGAGAGATGTATGATTCAAACATAGATGACTGGATTCCTGTTCCAGAATTGAGAACTAACCGTTGTAATGCAGGAGTGTGTGCTCTGAA
TGGAAAGTTATACATCGTTGGTGGCTCTGATCCATATGGTCAAAAAGGACTGAAAAATTGTGATGTATTTGATCCTGTAACAAAGTTGTG
GACAAGCTGTGCCCCTCTTAACATTCGGAGACACCAGTCTGCAGTCTGTGAGCTTGGTGGTTATTTGTACATAATCGGAGGTGCAGAATC
TTGGAATTGTCTGAACACAGTAGAACGATACAATCCTGAAAATAATACCTGGACTTTAATTGCACCCATGAATGTGGCTAGGCGAGGAGC
TGGAGTGGCTGTTCTTAATGGAAAACTGTTTGTATGTGGTGGCTTTGATGGTTCTCATGCCATCAGTTGTGTGGAAATGTATGATCCAAC
TAGAAATGAATGGAAGATGATGGGAAATATGACTTCACCAAGGAGCAATGCTGGGATTGCAACTGTAGGGAACACCATTTATGCAGTGGG
AGGATTCGATGGCAATGAATTTCTGAATACGGTGGAAGTCTATAACCTTGAGTCAAATGAATGGAGCCCCTATACAAAGATTTTCCAGTT
TTAACAAATTTAAGACCCTCTCAAACTAACAGGCTTAGTGATGTAATTATGGTTAGTAGAGGTACACTTGTGAATAAAGAGGGTGGGTGG
GTATAGATGTTGCTAACAGCAACACAAAGCTTTTGCATATTGCATACTATTAAACATGCTGTACATACTTTTTGGGTTTATTTGGAAAGG
AATGCAAAGATGAAGGTCTGTTTTGTGTACTTTTAAGACTTTGGTTATTTTACTTTTTGGAAAAGAATAAACCAAGAATTGATTGGGCAC
ATCATTTCAAGAAGTCCCCTCTCCTCCACATTTGTTTTGCCAATTTGCACATTAAATGACTCTTCCCTCAAATGTGTACTATGGGGTAAA
AGGGGTAGGGTTTAAAGATGTAGACAGTTGGGTTTTTTAAGGGCCCTTTTTCAATAACTGGAACACTCTATAACAAAGGATACTTATTTA
AATAGATGACATTGACTATTTTTGTTTTTATTAAAAGGAAGCTTACATGCCTACCAATATTTAATCTTTTATGATTGCCTTTTTATAACT
TTTTATATTCTCAGCAGAGTGCTTTACCAATTGAAGTAAAATGTGGCAGGCTGGAGTTATTGAAGCAGAGTGGCAGTCTTCAGTTTGCAG
AGTAGGGGTCTGTCTTTTAAACTCTGAGTGCAAACTTCAGAGTTCTTGCCTTGGCTGCAGTTTTTTTCCTTCAAGAATGCAGTACTAACA
TTTATTTGAGTGGAGTTACTGAACAGTAACATAGCTGTGATTTTTGGTATTTGAAACACTGGTTTTAAATATTTTGACTTGTTGAGGGTA
TGTTTTATATAGCAAGACATTATATAGCAGTAAAAAATGGTGTTTTATCTTCTATATAATTCCTGTTTTTATTATTAACAAAACAGTCCT
AAATAGCAGCCCTCAATTGTGAAAAAATTTACTTTAAACTACATTAGGTTGTGAATGCAGGTTTTATCAGAACTATGTTTTTGTTCAGTT
TATCTGTTCATATGGATAAATATTGGTTGGGATGACTTGGTGTCTAATGTGTAGTGCTACACACCTAACTTATGGGGCCAAAATAGCATG
TCCTAATGCTTGCTGCTGATTTAAACACATTAAAGGTACTTTGCAGGAAATCCTTGCACCATGGGATTAATATCCAATTGCTGCTTGTAC
ACTCATTCATTACTAAAAGTTTTGAGAAATTTTTTTTTCCAGTAATGAGCTTAAGAAATTTGTGGAAAATAACTCACCTGGCATCTTACA
TCTGAAATAAGGAATGATATAAGGTTTTTTTTTCTCACAGAAGATGAAGCACACAGGAACCTAATGGGCCAACTGGGATGAGGTGACTAT
TCTGAGATGACTATTCAGTGGCTAACTTGGGTTAGGAAGAAAATAATTAGGTATTTTCTCCAAATGTTCACTGGTACTCTGCCACTTTAT
TTCTCTCATCTGTTACACAAAGAACCACCAGGAAAGCAAATCAGTTTGGTTGGTAACTCTGTAATTCCTAACTATCACTGGTTTGGTTCT
GGACTAAAACTACATTGACAGATTGAATTTGCCTAATATGATGACTGTTTTTAATATGGATCTGTATGTGTTCTATTCAGCACAAGGAAA
TAAAATTTTAGTTGAGGATTCAGCACTAAAA

>7933_7933_2_ATP5B-IVNS1ABP_ATP5B_chr12_57037186_ENST00000552919_IVNS1ABP_chr1_185274775_ENST00000367498_length(amino acids)=687AA_BP=264
MLGFVGRVAAAPASGALRRLTPSASLPPAQLLLRAAPTAVHPVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILNALEVQG
RETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQ
EILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVQTLYY
SADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVI
FLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPR
ARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSC
APLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNE
WKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKIFQF

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Fusion Gene PPI Analysis for ATP5B-IVNS1ABP

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ATP5B-IVNS1ABP

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ATP5B-IVNS1ABP

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C0033578	Prostatic Neoplasms	1	CTD_human
Tgene		C0376358	Malignant neoplasm of prostate	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:ATP5B-IVNS1ABP (FusionGDB2 ID:HG506TG10625)

Fusion Gene Summary for ATP5B-IVNS1ABP

Fusion Gene ORF analysis for ATP5B-IVNS1ABP

Fusion Genomic Features for ATP5B-IVNS1ABP

Fusion Protein Features for ATP5B-IVNS1ABP

Fusion Gene Sequence for ATP5B-IVNS1ABP

Fusion Gene PPI Analysis for ATP5B-IVNS1ABP

Related Drugs for ATP5B-IVNS1ABP

Related Diseases for ATP5B-IVNS1ABP

Fusion Gene Studies
in Kim Lab