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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASAP1-CDKN2B (FusionGDB2 ID:HG50807TG1030)

Fusion Gene Summary for ASAP1-CDKN2B

check button Fusion gene summary
Fusion gene informationFusion gene name: ASAP1-CDKN2B
Fusion gene ID: hg50807tg1030
HgeneTgene
Gene symbol

ASAP1

CDKN2B

Gene ID

50807

1030

Gene nameArfGAP with SH3 domain, ankyrin repeat and PH domain 1cyclin dependent kinase inhibitor 2B
SynonymsAMAP1|CENTB4|DDEF1|PAG2|PAP|ZG14PCDK4I|INK4B|MTS2|P15|TP15|p15INK4b
Cytomap('ASAP1')('CDKN2B')

8q24.21-q24.22

9p21.3

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating proteinADP-ribosylcyclin-dependent kinase 4 inhibitor BCDK inhibitory proteinCDK4B inhibitorMTS-2cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)cyclin-dependent kinases 4 and 6 binding proteinmultiple tumor suppressor 2p14-INK4bp14_CDK inhibitorp14_INK4B
Modification date2020032720200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000357668, ENST00000518721, 
ENST00000520625, 
Fusion gene scores* DoF score25 X 17 X 13=55251 X 1 X 1=1
# samples 281
** MAII scorelog2(28/5525*10)=-4.30247573222119
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ASAP1 [Title/Abstract] AND CDKN2B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASAP1(131370263)-CDKN2B(22006246), # samples:2
Anticipated loss of major functional domain due to fusion event.ASAP1-CDKN2B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASAP1-CDKN2B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ASAP1-CDKN2B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ASAP1-CDKN2B seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCDKN2B

GO:0000079

regulation of cyclin-dependent protein serine/threonine kinase activity

8078588

TgeneCDKN2B

GO:0042326

negative regulation of phosphorylation

8078588


check buttonFusion gene breakpoints across ASAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CDKN2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-FS-A1ZE-06AASAP1chr8

131370263

-CDKN2Bchr9

22006246

-


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Fusion Gene ORF analysis for ASAP1-CDKN2B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000357668ENST00000380142ASAP1chr8

131370263

-CDKN2Bchr9

22006246

-
5CDS-3UTRENST00000518721ENST00000380142ASAP1chr8

131370263

-CDKN2Bchr9

22006246

-
5CDS-intronENST00000357668ENST00000539462ASAP1chr8

131370263

-CDKN2Bchr9

22006246

-
5CDS-intronENST00000518721ENST00000539462ASAP1chr8

131370263

-CDKN2Bchr9

22006246

-
Frame-shiftENST00000357668ENST00000276925ASAP1chr8

131370263

-CDKN2Bchr9

22006246

-
In-frameENST00000518721ENST00000276925ASAP1chr8

131370263

-CDKN2Bchr9

22006246

-
intron-3CDSENST00000520625ENST00000276925ASAP1chr8

131370263

-CDKN2Bchr9

22006246

-
intron-3UTRENST00000520625ENST00000380142ASAP1chr8

131370263

-CDKN2Bchr9

22006246

-
intron-intronENST00000520625ENST00000539462ASAP1chr8

131370263

-CDKN2Bchr9

22006246

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000518721ASAP1chr8131370263-ENST00000276925CDKN2Bchr922006246-3759414228674148

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000518721ENST00000276925ASAP1chr8131370263-CDKN2Bchr922006246-0.0191511380.98084885

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Fusion Genomic Features for ASAP1-CDKN2B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ASAP1-CDKN2B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:131370263/chr9:22006246)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDKN2Bchr8:131370263chr9:22006246ENST0000027692502112_13852139.0RepeatNote=ANK 4
TgeneCDKN2Bchr8:131370263chr9:22006246ENST000002769250279_10852139.0RepeatNote=ANK 3
TgeneCDKN2Bchr8:131370263chr9:22006246ENST0000038014202112_1389379.0RepeatNote=ANK 4
TgeneCDKN2Bchr8:131370263chr9:22006246ENST0000053946201112_138079.0RepeatNote=ANK 4
TgeneCDKN2Bchr8:131370263chr9:22006246ENST000005394620113_39079.0RepeatNote=ANK 1%3B truncated
TgeneCDKN2Bchr8:131370263chr9:22006246ENST000005394620146_74079.0RepeatNote=ANK 2
TgeneCDKN2Bchr8:131370263chr9:22006246ENST000005394620179_108079.0RepeatNote=ANK 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASAP1chr8:131370263chr9:22006246ENST00000357668-229783_993621130.0Compositional biasNote=Pro-rich
HgeneASAP1chr8:131370263chr9:22006246ENST00000518721-330783_993621130.0Compositional biasNote=Pro-rich
HgeneASAP1chr8:131370263chr9:22006246ENST00000357668-2291067_1129621130.0DomainSH3
HgeneASAP1chr8:131370263chr9:22006246ENST00000357668-229324_416621130.0DomainPH
HgeneASAP1chr8:131370263chr9:22006246ENST00000357668-229439_560621130.0DomainArf-GAP
HgeneASAP1chr8:131370263chr9:22006246ENST00000518721-3301067_1129621130.0DomainSH3
HgeneASAP1chr8:131370263chr9:22006246ENST00000518721-330324_416621130.0DomainPH
HgeneASAP1chr8:131370263chr9:22006246ENST00000518721-330439_560621130.0DomainArf-GAP
HgeneASAP1chr8:131370263chr9:22006246ENST00000357668-229600_632621130.0RepeatNote=ANK 1
HgeneASAP1chr8:131370263chr9:22006246ENST00000357668-229636_665621130.0RepeatNote=ANK 2
HgeneASAP1chr8:131370263chr9:22006246ENST00000518721-330600_632621130.0RepeatNote=ANK 1
HgeneASAP1chr8:131370263chr9:22006246ENST00000518721-330636_665621130.0RepeatNote=ANK 2
HgeneASAP1chr8:131370263chr9:22006246ENST00000357668-229454_477621130.0Zinc fingerC4-type
HgeneASAP1chr8:131370263chr9:22006246ENST00000518721-330454_477621130.0Zinc fingerC4-type
TgeneCDKN2Bchr8:131370263chr9:22006246ENST000002769250213_3952139.0RepeatNote=ANK 1%3B truncated
TgeneCDKN2Bchr8:131370263chr9:22006246ENST000002769250246_7452139.0RepeatNote=ANK 2
TgeneCDKN2Bchr8:131370263chr9:22006246ENST000003801420213_399379.0RepeatNote=ANK 1%3B truncated
TgeneCDKN2Bchr8:131370263chr9:22006246ENST000003801420246_749379.0RepeatNote=ANK 2
TgeneCDKN2Bchr8:131370263chr9:22006246ENST000003801420279_1089379.0RepeatNote=ANK 3


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Fusion Gene Sequence for ASAP1-CDKN2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6952_6952_1_ASAP1-CDKN2B_ASAP1_chr8_131370263_ENST00000518721_CDKN2B_chr9_22006246_ENST00000276925_length(transcript)=3759nt_BP=414nt
CCCTTCCTGCGCCGCGCTCGGCTCCCGCGCCTCGCCTGGCCTGGCCGCTGCCGCGGGCGAGCACTGTGCGCTGGGCAGCCCCGGGCCCGC
GCCTCCCGCCCAGCCGGCGCTTCCCGGTCGCAGTTCGCTTTCCCACCCGAGAGCCGCGAGCGCCCGGCCGAACCCGCGATGGAATAATGC
CCAGCGGCCCGCCAGGTCCCGGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGA
GATTCACTATGGAATCGGATGCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCC
AGCTTCACCACGCGGCTGCACAACTGCAGGAACACCGTCACGCTGCTGGAGGAGGTCATGATGATGGGCAGCGCCCGCGTGGCGGAGCTG
CTGCTGCTCCACGGCGCGGAGCCCAACTGCGCAGACCCTGCCACTCTCACCCGACCGGTGCATGATGCTGCCCGGGAGGGCTTCCTGGAC
ACGCTGGTGGTGCTGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGTCGTCTGCCCGTGGACTTGGCCGAGGAGCGGGGC
CACCGCGACGTTGCAGGGTACCTGCGCACAGCCACGGGGGACTGACGCCAGGTTCCCCAGCCGCCCACAACGACTTTATTTTCTTACCCA
ATTTCCCACCCCCACCCACCTAATTCGATGAAGGCTGCCAACGGGGAGCGGCGGAAAGCCTGTAAGCCTGCAAGCCTGTCTGAGACTCAC
AGGAAGGAGGAGCCGACCGGGAATAACCTTCCATACATTTTTTTCTTTGTCTTATCTGGCCCTCGACACTCACCATGAAGCGAAACACAG
AGAAGCGGATTTCCAGGGATATTTAGGAGTGTGTGACATTCCAGGGGTCGTTTGCTTTTCAGGGTTTTCTGAGGGAAAGTGCATATGAAA
TCCTTGACTGGACCTGGTGGCTACGAATCTTCCGATGGATGAATCTCCCACTCCAGCGCTGAGTGGGAGAAGGCAGTGATTAGCACTTGG
GTGACGGCAGTCGATGCGTTCACTCCAATGTCTGCTGAGGAGTTATGGTGAACCCACAACTTAGGCCCTAGCGGCAGAAAGGAAAACCTG
AAGACTGAGGACAAAGTGGAGGAGGGCCGAGGTGGGCTTCAGTAAGTCCCCGGCGGCGCTTTAGTTTGAGCGCATGGCAAGTCACATGCG
TAAACGACACTCTCTGGAAGCCCTGGAGACCCTCGCCCAACTCCACCAGATAGCAGAGGGGTAAGAGAGGATGTGCAAGCGACGACAGAT
GCTAAAATCCCTGGATCACGACGCTGCAGAGCACCTTTGCACAGGATGCTGGCCTTTGCTCTTACTACACTGAGGAGAGATTCCCGCGGG
TTCCGCAGGCAGACTACACAGGATGAGGTGGTGGAGTGGAGTGAGAGCAATTGTAACGGTTAACTGTAACGTTTTCTTTCACACACACAC
ACACACACACACACACACATGCTAGGATGCGGAAATCCCCTTATGACTTGCTACTTTTTGATTTTGTGATATTTTGTACTTTTTAGTTGT
TCAGCAACTGTCTTATTTAATGGGGAGATTTTAAGTAACATAACTAGTGGCTCTCAGTTAAAATGTGAGGAAGAACTACAGCTCTTAAAT
GTAGCAATGGCACTGTTGCAAACTCAGTGCAAACGCCTAGATTGCTTTCTTCTTAACCTATTTATTTCTTTGTTAAATTTTTCTGATTGT
TTCCTTTATAGAGTGTCTCAGGGTGCAGAGGTCAGACTAAGAAATATTCCAAATGTCTTTTAGAAGATAGATGCACTTATGCAGTAAATT
ATCTTGGGATAGTTCCCAAAAGATTGCTGAAAAAGTAGATTGAGTATAAAAACTTGAAAATATATGATGGCTCGTGGGATGTCCTACTAT
CACTGAACAAACTAAAGGTGCACTGCTTTGGGATTTAATTTCCAGGGTTGCTTGATCATTATATCATTGGAACAACTGATACTTCACTAC
TTTAATAAAGAATTAACAGAGATTGAACTCCAAGAGGTGGGTAATTTGGTTTAAAAATACATGTTCATGGGTTTACCACTAACTCCTGAG
AAATGTTAAAGGTTCACAGGGGTTCCCTTCTCTCAATGTTTGTAATAATTGCTCATAAGCAATACCAGCAATTCATAAAAACTGCTTACT
TATGCCATAGAAAATTAAACACAAAGTGTATACATGTATTATGCTTCTAAATGCTCATTCTACCAGATACACATTTAAAAGAGAAAAAAG
GAACAGAAACAAGTCATTTGAGAGTGGAGACTTATAAGAAGGAGTACATTTGAGTTGAATACACAAATCTTTACTTCTCTACCAATTCCT
ATTCCCAAAATGAACATATTACTGGGGAAAGTTAGTTGAGAATCAGAGCATATGTTATTGGGGAAAGGATATGTTTATTGACACATAATC
TGTACCAGGTATGCATTAAAATATATTTGTTAATTTAATATTTAAACCTGAGAGATAGGTATTGTTTCCCAGATGAGGACAATGAGGCAA
AGAAATATCAAGTAACTTGCCAAAGGTTACAAGATATTCATTCCATGGATGCACAAAGAAGTGCATCTAGTTCCACAGCTGATTATGGTT
GTCTTGCTTTTCTTCCCATTGCACCAGCTTGTCCTCCAAAATCATGAATGATACACATGAAGATAACTTTTTTTAAAAAAAAGCAGAAAT
ACACAATGATCTCCCTTGTAAGCTCCTAAGGTGGCTTTTCTTTCTCTAACTTCTAGTAAATATAAACGGTTTGTTTGAAAACTATTTTAA
AATGTCAACAATATGGAGAATAACCCCCCCCAACACACCTATAAAAACCCAAATTTTTGGAACAAAGATAATGGAACCTCCATTTTCAAA
CTGAAGCACAGGGACAGAAAATATATTTCTAGTTATCACTTAAGCACTCAATCATTAGAGGCTACAAGAATAATATTTTTAAAGTTACAG
TATTTTACAATTATTAGAAAACATTCTATATAAAAGAAGTCAGTTGATACTTTAAAATCTCCCATTTGGTTTATAAAATCCCTTAATTTG
ACCTCTATATCTTAAATTCCAAGATGTTTAAATTTGCTAGTTGCATTATACTGGGTCATGAAAAATTATCCCTTGAAATAGATATGAAAC
ATGTTACTTCATTTCTGGTTTAAATAACTTGTGGAATCTTTCCTAATGACAACCTGATATTAAGGGAAACTAAAGAAAATGTTATTGTGG
ATCCCACAGTACTATATTACACTGTTTTTTTTGTTTGTTTTGTTAGTTTTTTTTATTTAAAGCAAACCTCAAACATTATTGGGTATCAAT
TACCACCTGGTTGTATTGAAATAGTAACTTATCAATGCCATGTAAAAATTAATTCCATTTTCGAAGCCACCTGGCAGACAGGTTTAGCTG
TTTCATCAGCAGCCTAATATATACTGTTAAATTTGTTAAGGATTTCACTTTGAAGGATACATGCAAAACATATAGTTACTATTTTCATGA
GTCCTGCTTCTAGCTCCATTGTGGAATACAGAAAATTAAATATACCTGTTAAGTTCGTATCTAAACCTAAGACATTACCAAGGTTTGTAC

>6952_6952_1_ASAP1-CDKN2B_ASAP1_chr8_131370263_ENST00000518721_CDKN2B_chr9_22006246_ENST00000276925_length(amino acids)=148AA_BP=62
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEVMMMGSARVAELLLLHGAEPNCADPATL

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Fusion Gene PPI Analysis for ASAP1-CDKN2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASAP1-CDKN2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASAP1-CDKN2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASAP1C0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneASAP1C0005695Bladder Neoplasm1CTD_human
HgeneASAP1C0041327Tuberculosis, Pulmonary1CTD_human
HgeneASAP1C0087031Juvenile-Onset Still Disease1CTD_human
HgeneASAP1C3495559Juvenile arthritis1CTD_human
HgeneASAP1C3714758Juvenile psoriatic arthritis1CTD_human
HgeneASAP1C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneASAP1C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneC0017638Glioma2CGI;CTD_human
TgeneC0259783mixed gliomas2CTD_human
TgeneC0555198Malignant Glioma2CTD_human
TgeneC0010054Coronary Arteriosclerosis1CTD_human
TgeneC0017601Glaucoma1CTD_human
TgeneC0024299Lymphoma1CTD_human
TgeneC0025267Multiple Endocrine Neoplasia Type 11ORPHANET
TgeneC1956346Coronary Artery Disease1CTD_human
TgeneC2713368Hematopoetic Myelodysplasia1CTD_human
TgeneC3463824MYELODYSPLASTIC SYNDROME1CTD_human