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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AK3-RCL1 (FusionGDB2 ID:HG50808TG10171)

Fusion Gene Summary for AK3-RCL1

check button Fusion gene summary
Fusion gene informationFusion gene name: AK3-RCL1
Fusion gene ID: hg50808tg10171
HgeneTgene
Gene symbol

AK3

RCL1

Gene ID

50808

10171

Gene nameadenylate kinase 3RNA terminal phosphate cyclase like 1
SynonymsAK3L1|AK6|AKL3L|AKL3L1|FIXRNAC|RPCL1
Cytomap('AK3')('RCL1')

9p24.1

9p24.1

Type of geneprotein-codingprotein-coding
DescriptionGTP:AMP phosphotransferase AK3, mitochondrialGTP:AMP phosphotransferase, mitochondrialadenylate kinase 3 alpha-like 1adenylate kinase 6, adenylate kinase 3 like 1RNA 3'-terminal phosphate cyclase-like proteinRNA cyclase homolog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000359883, ENST00000381809, 
ENST00000447596, 
Fusion gene scores* DoF score6 X 5 X 4=1207 X 8 X 6=336
# samples 89
** MAII scorelog2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AK3 [Title/Abstract] AND RCL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAK3(4722506)-RCL1(4823548), # samples:3
Anticipated loss of major functional domain due to fusion event.AK3-RCL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AK3-RCL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AK3-RCL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AK3-RCL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AK3-RCL1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
AK3-RCL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAK3

GO:0046033

AMP metabolic process

11485571

HgeneAK3

GO:0046039

GTP metabolic process

11485571

HgeneAK3

GO:0046041

ITP metabolic process

11485571

HgeneAK3

GO:0046051

UTP metabolic process

11485571


check buttonFusion gene breakpoints across AK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RCL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CR-7399-01AAK3chr9

4722506

-RCL1chr9

4823548

+
ChimerDB4HNSCTCGA-CR-7399AK3chr9

4722506

-RCL1chr9

4823548

+
ChimerDB4HNSCTCGA-CR-7399AK3chr9

4740936

-RCL1chr9

4823547

+
ChimerDB4HNSCTCGA-CR-7399AK3chr9

4740937

-RCL1chr9

4823548

+


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Fusion Gene ORF analysis for AK3-RCL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000359883ENST00000381728AK3chr9

4722506

-RCL1chr9

4823548

+
5CDS-intronENST00000359883ENST00000381730AK3chr9

4722506

-RCL1chr9

4823548

+
5CDS-intronENST00000359883ENST00000381732AK3chr9

4722506

-RCL1chr9

4823548

+
5CDS-intronENST00000359883ENST00000445485AK3chr9

4722506

-RCL1chr9

4823548

+
5CDS-intronENST00000359883ENST00000448872AK3chr9

4722506

-RCL1chr9

4823548

+
5CDS-intronENST00000381809ENST00000381728AK3chr9

4722506

-RCL1chr9

4823548

+
5CDS-intronENST00000381809ENST00000381728AK3chr9

4740936

-RCL1chr9

4823547

+
5CDS-intronENST00000381809ENST00000381728AK3chr9

4740937

-RCL1chr9

4823548

+
5CDS-intronENST00000381809ENST00000381730AK3chr9

4722506

-RCL1chr9

4823548

+
5CDS-intronENST00000381809ENST00000381730AK3chr9

4740936

-RCL1chr9

4823547

+
5CDS-intronENST00000381809ENST00000381730AK3chr9

4740937

-RCL1chr9

4823548

+
5CDS-intronENST00000381809ENST00000381732AK3chr9

4722506

-RCL1chr9

4823548

+
5CDS-intronENST00000381809ENST00000381732AK3chr9

4740936

-RCL1chr9

4823547

+
5CDS-intronENST00000381809ENST00000381732AK3chr9

4740937

-RCL1chr9

4823548

+
5CDS-intronENST00000381809ENST00000445485AK3chr9

4722506

-RCL1chr9

4823548

+
5CDS-intronENST00000381809ENST00000445485AK3chr9

4740936

-RCL1chr9

4823547

+
5CDS-intronENST00000381809ENST00000445485AK3chr9

4740937

-RCL1chr9

4823548

+
5CDS-intronENST00000381809ENST00000448872AK3chr9

4722506

-RCL1chr9

4823548

+
5CDS-intronENST00000381809ENST00000448872AK3chr9

4740936

-RCL1chr9

4823547

+
5CDS-intronENST00000381809ENST00000448872AK3chr9

4740937

-RCL1chr9

4823548

+
5CDS-intronENST00000447596ENST00000381728AK3chr9

4740936

-RCL1chr9

4823547

+
5CDS-intronENST00000447596ENST00000381728AK3chr9

4740937

-RCL1chr9

4823548

+
5CDS-intronENST00000447596ENST00000381730AK3chr9

4740936

-RCL1chr9

4823547

+
5CDS-intronENST00000447596ENST00000381730AK3chr9

4740937

-RCL1chr9

4823548

+
5CDS-intronENST00000447596ENST00000381732AK3chr9

4740936

-RCL1chr9

4823547

+
5CDS-intronENST00000447596ENST00000381732AK3chr9

4740937

-RCL1chr9

4823548

+
5CDS-intronENST00000447596ENST00000445485AK3chr9

4740936

-RCL1chr9

4823547

+
5CDS-intronENST00000447596ENST00000445485AK3chr9

4740937

-RCL1chr9

4823548

+
5CDS-intronENST00000447596ENST00000448872AK3chr9

4740936

-RCL1chr9

4823547

+
5CDS-intronENST00000447596ENST00000448872AK3chr9

4740937

-RCL1chr9

4823548

+
Frame-shiftENST00000359883ENST00000381750AK3chr9

4722506

-RCL1chr9

4823548

+
Frame-shiftENST00000381809ENST00000381750AK3chr9

4740936

-RCL1chr9

4823547

+
Frame-shiftENST00000381809ENST00000381750AK3chr9

4740937

-RCL1chr9

4823548

+
Frame-shiftENST00000447596ENST00000381750AK3chr9

4740936

-RCL1chr9

4823547

+
Frame-shiftENST00000447596ENST00000381750AK3chr9

4740937

-RCL1chr9

4823548

+
In-frameENST00000381809ENST00000381750AK3chr9

4722506

-RCL1chr9

4823548

+
intron-3CDSENST00000359883ENST00000381750AK3chr9

4740936

-RCL1chr9

4823547

+
intron-3CDSENST00000359883ENST00000381750AK3chr9

4740937

-RCL1chr9

4823548

+
intron-3CDSENST00000447596ENST00000381750AK3chr9

4722506

-RCL1chr9

4823548

+
intron-intronENST00000359883ENST00000381728AK3chr9

4740936

-RCL1chr9

4823547

+
intron-intronENST00000359883ENST00000381728AK3chr9

4740937

-RCL1chr9

4823548

+
intron-intronENST00000359883ENST00000381730AK3chr9

4740936

-RCL1chr9

4823547

+
intron-intronENST00000359883ENST00000381730AK3chr9

4740937

-RCL1chr9

4823548

+
intron-intronENST00000359883ENST00000381732AK3chr9

4740936

-RCL1chr9

4823547

+
intron-intronENST00000359883ENST00000381732AK3chr9

4740937

-RCL1chr9

4823548

+
intron-intronENST00000359883ENST00000445485AK3chr9

4740936

-RCL1chr9

4823547

+
intron-intronENST00000359883ENST00000445485AK3chr9

4740937

-RCL1chr9

4823548

+
intron-intronENST00000359883ENST00000448872AK3chr9

4740936

-RCL1chr9

4823547

+
intron-intronENST00000359883ENST00000448872AK3chr9

4740937

-RCL1chr9

4823548

+
intron-intronENST00000447596ENST00000381728AK3chr9

4722506

-RCL1chr9

4823548

+
intron-intronENST00000447596ENST00000381730AK3chr9

4722506

-RCL1chr9

4823548

+
intron-intronENST00000447596ENST00000381732AK3chr9

4722506

-RCL1chr9

4823548

+
intron-intronENST00000447596ENST00000445485AK3chr9

4722506

-RCL1chr9

4823548

+
intron-intronENST00000447596ENST00000448872AK3chr9

4722506

-RCL1chr9

4823548

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000381809AK3chr94722506-ENST00000381750RCL1chr94823548+22775021951487430

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381809ENST00000381750AK3chr94722506-RCL1chr94823548+0.0010773950.9989225

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Fusion Genomic Features for AK3-RCL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AK3chr94722505-RCL1chr94823547+7.22E-080.9999999
AK3chr94722505-RCL1chr94823547+7.22E-080.9999999
AK3chr94740936-RCL1chr94823547+5.44E-101
AK3chr94722505-RCL1chr94823547+7.22E-080.9999999
AK3chr94722505-RCL1chr94823547+7.22E-080.9999999
AK3chr94740936-RCL1chr94823547+5.44E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AK3-RCL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:4722506/chr9:4823548)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAK3chr9:4722506chr9:4823548ENST00000359883-2517_2220158.0Nucleotide bindingGTP
HgeneAK3chr9:4722506chr9:4823548ENST00000381809-2517_2290228.0Nucleotide bindingGTP
HgeneAK3chr9:4722506chr9:4823548ENST00000381809-2564_6690228.0Nucleotide bindingAMP
HgeneAK3chr9:4722506chr9:4823548ENST00000381809-2537_6690228.0RegionNMP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAK3chr9:4722506chr9:4823548ENST00000359883-25137_13820158.0Nucleotide bindingGTP
HgeneAK3chr9:4722506chr9:4823548ENST00000359883-2564_6620158.0Nucleotide bindingAMP
HgeneAK3chr9:4722506chr9:4823548ENST00000359883-2591_9420158.0Nucleotide bindingAMP
HgeneAK3chr9:4722506chr9:4823548ENST00000381809-25137_13890228.0Nucleotide bindingGTP
HgeneAK3chr9:4722506chr9:4823548ENST00000381809-2591_9490228.0Nucleotide bindingAMP
HgeneAK3chr9:4722506chr9:4823548ENST00000447596-14137_1380188.0Nucleotide bindingGTP
HgeneAK3chr9:4722506chr9:4823548ENST00000447596-1417_220188.0Nucleotide bindingGTP
HgeneAK3chr9:4722506chr9:4823548ENST00000447596-1464_660188.0Nucleotide bindingAMP
HgeneAK3chr9:4722506chr9:4823548ENST00000447596-1491_940188.0Nucleotide bindingAMP
HgeneAK3chr9:4722506chr9:4823548ENST00000359883-25127_16420158.0RegionLID
HgeneAK3chr9:4722506chr9:4823548ENST00000359883-2537_6620158.0RegionNMP
HgeneAK3chr9:4722506chr9:4823548ENST00000381809-25127_16490228.0RegionLID
HgeneAK3chr9:4722506chr9:4823548ENST00000447596-14127_1640188.0RegionLID
HgeneAK3chr9:4722506chr9:4823548ENST00000447596-1437_660188.0RegionNMP


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Fusion Gene Sequence for AK3-RCL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3242_3242_1_AK3-RCL1_AK3_chr9_4722506_ENST00000381809_RCL1_chr9_4823548_ENST00000381750_length(transcript)=2277nt_BP=502nt
GTCGGGGGCGGGGGGTGCGCCGGGGTAGCCGAGAGGCGGACGCAACAGCGGGGTCCCGCGCTGTCTGGGCGGCCCCAGGGGCTGTCGGCT
CACTTCCGGGAACGCCGGGGAACCGCAGTAGCCGCCTGCTAGTGGCGCTGCTAGCCGGCCGGCGCAGGCTGCCGAGCGGGTGAGCGCGCA
GGCCAGGCCAAAGCCCTGGTACCCGCGCGGTGCGGGCCTCAGTCTGCGGCCATGGGGGCGTCCGCGCGGCTGCTGCGAGCGGTGATCATG
GGGGCCCCGGGCTCGGGCAAGGGCACCGTGTCGTCGCGCATCACTACACACTTCGAGCTGAAGCACCTCTCCAGCGGGGACCTGCTCCGG
GACAACATGCTGCGGGGCACAGAAATTGGCGTGTTAGCCAAGGCTTTCATTGACCAAGGGAAACTCATCCCAGATGATGTCATGACTCGG
CTGGCCCTTCATGAGCTGAAAAATCTCACCCAGTATAGCTGGCTGTTGGATGATTTTGAAGCCAGCTTCATAAGGCTATTGGACAAAATA
ACGAATGGTTCTCGAATTGAAATAAACCAAACAGGAACAACCTTATATTATCAGCCTGGCCTCCTGTATGGTGGATCTGTGGAACATGAC
TGTAGCGTCCTTCGTGGCATTGGGTATTACCTGGAGAGTCTTCTTTGCTTGGCTCCATTTATGAAGCACCCGTTAAAAATAGTTCTACGA
GGAGTGACCAATGATCAGGTTGACCCTTCAGTTGATGTTCTTAAGGCAACAGCACTCCCTTTGTTGAAACAATTTGGGATTGATGGTGAA
TCATTTGAACTGAAGATTGTGCGACGGGGAATGCCTCCCGGAGGAGGAGGCGAAGTGGTTTTCTCATGTCCTGTGAGGAAGGTCTTGAAG
CCCATTCAACTCACAGATCCAGGAAAAATCAAACGTATTAGAGGAATGGCGTACTCTGTACGTGTGTCACCTCAGATGGCGAACCGGATT
GTGGATTCTGCAAGGAGCATCCTCAACAAGTTCATACCTGATATCTATATTTACACAGATCACATGAAAGGAGTCAACTCTGGGAAGTCT
CCGGGCTTTGGGTTGTCACTGGTTGCTGAGACCACCAGTGGCACCTTCCTCAGTGCTGAACTGGCCTCCAACCCCCAGGGCCAGGGAGCA
GCAGTACTTCCAGAGGACCTTGGCAGGAACTGTGCCCGGCTGCTGCTGGAGGAAATCTACAGGGGTGGATGCGTAGACTCGACCAACCAA
AGCCTGGCGCTACTACTCATGACCCTTGGACAGCAGGATGTTTCCAAAGTCCTGCTAGGCCCTCTCTCTCCCTACACGATAGAATTTTTG
CGGCATTTGAAGAGCTTTTTCCAGATTATGTTTAAAATTGAAACCAAGCCATGTGGTGAAGAACTCAAGGGTGGGGATAAAGTGCTGATG
ACCTGTGTTGGCATTGGTTTCTCCAACCTTAGCAAGACCCTCAAGTGATAACCATCACAAGATAAGGCCCCAATGCCTACAGACAAAGCA
GAAGCTGCCACGGACACCAATGGGACCAAGTCCAAATGGATTAATCCAGGACAGAATAGCCACTTGCTTAATTTTCTGTGAAGAAATATC
AATATACAAATAAAAGACATCCCTGTAGCATATGGTTTCCAGCTGTTTCTCCAGTGGCATTGCCATTGCCCAGGAGGGGCCCAGTCACCA
TGAGAGCTCCCTTGCCTTACCTGGAGGAAGAATGTGCCTTCAGGCCACAGTCGTGCTGCTAGAACAGTCTCGTAGCTGCAGTTCAGCTGT
GCTTCCTCAGCCTACTATCATAGGCTTCCTCAGCCCTCTGTCATATGGCTGTTTTGCAAACCTGTGGAGTCTGTTACTGTTCTTTCTGCA
AGGACTCACCTCCTTGAGCCTTGGTTTTTGTTGTAGGGATTAAATGAGATAATATGAGTGGCAGCTCTTCATGAGTCCTGCAGTGCTAAG
CAAATGTCAGAAATTGGTGTATTAGACTATTTATCTTTGATCTTCTGAATGGATTGCTGTCATGGACACGGACACGGATCTTCATCTGGT
TCATTGTATTTATATGTGAGGGATGGATGGCTGCGGGGCTCCAAGTAAGTTATTGGGATGTTTTTATATTCCAGGTGTGCTGTACATTCT
TATTTTATTTTCACAATAGCTCTGTGATGTAAGTGCTATCTCCATGAGAAAATTCATAAAGGGTGTTTTGTTCCTTTGAAATGTATAATG

>3242_3242_1_AK3-RCL1_AK3_chr9_4722506_ENST00000381809_RCL1_chr9_4823548_ENST00000381750_length(amino acids)=430AA_BP=102
MVPARCGPQSAAMGASARLLRAVIMGAPGSGKGTVSSRITTHFELKHLSSGDLLRDNMLRGTEIGVLAKAFIDQGKLIPDDVMTRLALHE
LKNLTQYSWLLDDFEASFIRLLDKITNGSRIEINQTGTTLYYQPGLLYGGSVEHDCSVLRGIGYYLESLLCLAPFMKHPLKIVLRGVTND
QVDPSVDVLKATALPLLKQFGIDGESFELKIVRRGMPPGGGGEVVFSCPVRKVLKPIQLTDPGKIKRIRGMAYSVRVSPQMANRIVDSAR
SILNKFIPDIYIYTDHMKGVNSGKSPGFGLSLVAETTSGTFLSAELASNPQGQGAAVLPEDLGRNCARLLLEEIYRGGCVDSTNQSLALL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AK3-RCL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AK3-RCL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AK3-RCL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0152013Adenocarcinoma of lung (disorder)1CTD_human