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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PCBP2-CDS2 (FusionGDB2 ID:HG5094TG8760)

Fusion Gene Summary for PCBP2-CDS2

check button Fusion gene summary
Fusion gene informationFusion gene name: PCBP2-CDS2
Fusion gene ID: hg5094tg8760
HgeneTgene
Gene symbol

PCBP2

CDS2

Gene ID

5094

8760

Gene namepoly(rC) binding protein 2CDP-diacylglycerol synthase 2
SynonymsHNRNPE2|HNRPE2|hnRNP-E2-
Cytomap('PCBP2')('CDS2')

12q13.13

20p12.3

Type of geneprotein-codingprotein-coding
Descriptionpoly(rC)-binding protein 2alpha-CP2epididymis secretory sperm binding proteinheterogeneous nuclear ribonucleoprotein E2heterogenous nuclear ribonucleoprotein E2hnRNP E2phosphatidate cytidylyltransferase 2CDP-DAG synthase 2CDP-DG synthase 2CDP-DG synthetase 2CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2CDP-diglyceride diphosphorylase 2CDP-diglyceride pyrophosphorylase 2CDP-diglyceride synthase
Modification date2020031320200327
UniProtAcc.

O95674

Ensembl transtripts involved in fusion geneENST00000359282, ENST00000359462, 
ENST00000437231, ENST00000447282, 
ENST00000455667, ENST00000546463, 
ENST00000549863, ENST00000552819, 
ENST00000603815, ENST00000439930, 
ENST00000541275, ENST00000548933, 
ENST00000552296, 
ENST00000359282, 
ENST00000359462, ENST00000437231, 
ENST00000447282, ENST00000455667, 
ENST00000549863, ENST00000552819, 
ENST00000603815, ENST00000439930, 
ENST00000541275, ENST00000546463, 
ENST00000548933, ENST00000552296, 
Fusion gene scores* DoF score34 X 29 X 12=1183210 X 11 X 7=770
# samples 4513
** MAII scorelog2(45/11832*10)=-4.71662514588203
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/770*10)=-2.56634682255381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCBP2 [Title/Abstract] AND CDS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPCBP2(53873467)-CDS2(5177892), # samples:112
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePCBP2

GO:0039694

viral RNA genome replication

12414943

HgenePCBP2

GO:0075522

IRES-dependent viral translational initiation

12414943



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-49-4490-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-49-6745-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-49-6761-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-50-5930-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-50-5935-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-55-6975-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-55-6981-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-55-6984-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-55-6984-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-55-6986-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-91-6847-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-91-6849-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-A3-3358-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-A3-3387-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-A7-A0CH-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-A7-A0CH-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-AC-A23H-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-AC-A2FB-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-AC-A2FF-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-AJ-A3NC-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-AX-A0IZ-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-B0-4712-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-B0-4712-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-B0-5402-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-B0-5402-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-B0-5690-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-B0-5690-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-B0-5701-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-B0-5701-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-B0-5703-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-B0-5709-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-B0-5711-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-B0-5711-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-B0-5712-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-B2-5641-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-B8-4619-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-B8-4622-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-B8-5549-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A0B7-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A0B7-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A0BA-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A0BM-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A0BQ-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A0BQ-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A0BS-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A0BT-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A0BV-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A0BW-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A0BZ-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A0C0-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A0C3-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A0DG-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A0DL-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A0DO-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A0DP-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A0DQ-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A0DT-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A0DT-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A0DV-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A0DV-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A0H5-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A0H5-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A0H7-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A0HA-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A18M-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A18N-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A18N-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A18P-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A18Q-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A18R-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A18S-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A18V-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A1EN-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A1EN-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A1EO-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A1EO-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A1ET-11BPCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A1EU-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A1EV-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A1EV-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A1EW-11BPCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A1EW-11BPCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A1F0-11BPCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A1F0-11BPCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A1F2-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A1F2-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A1F6-11BPCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A1F6-11BPCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A1FE-11BPCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A1FG-11BPCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A1FG-11BPCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A1FH-11BPCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A1FJ-11BPCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A1FM-11BPCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A1FM-11BPCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A1FN-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A1FN-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A1FR-11BPCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A203-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BH-A203-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BH-A209-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BJ-A2N7-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-BJ-A2N7-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BJ-A2N8-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BT-A20U-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-BT-A2LA-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CJ-5677-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CJ-5678-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CJ-5680-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CJ-5680-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CJ-5681-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CJ-6030-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CW-5580-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CW-5580-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CW-5584-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CW-5584-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CW-5585-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CW-6087-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CW-6087-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CW-6088-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CW-6088-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CW-6090-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CW-6090-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CZ-5451-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CZ-5451-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CZ-5453-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CZ-5453-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CZ-5454-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CZ-5454-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CZ-5457-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CZ-5458-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CZ-5461-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CZ-5463-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CZ-5465-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CZ-5465-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CZ-5466-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CZ-5466-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CZ-5467-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CZ-5468-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CZ-5469-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CZ-5469-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CZ-5470-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CZ-5470-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CZ-5982-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CZ-5985-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CZ-5985-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CZ-5986-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CZ-5987-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-CZ-5987-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-CZ-5989-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-E2-A153-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-E2-A15I-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-E2-A15I-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-E2-A15M-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-E2-A1LH-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-E2-A1LS-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-E9-A1N6-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-E9-A1N6-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-E9-A1ND-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-E9-A1ND-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-E9-A1RB-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-E9-A1RC-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-E9-A1RD-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-E9-A1RH-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-E9-A1RI-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-E9-A1RI-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-EL-A3H1-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-EL-A3MY-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-EL-A3N2-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-EL-A3ZG-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-EL-A3ZL-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-EL-A3ZP-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-EL-A3ZP-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-EM-A1CT-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-EM-A1CT-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-ET-A3DP-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-ET-A3DP-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-FL-A1YI-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-GI-A2C9-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-GN-A4U8-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-GN-A4U8-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-HM-A3JJ-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-KL-8326-11APCBP2chr12

53873452

+CDS2chr20

5177877

+
ChimerDB4Non-CancerTCGA-KL-8326-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-KL-8332-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-KN-8424-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-KN-8428-11APCBP2chr12

53873467

+CDS2chr20

5177892

+
ChimerDB4Non-CancerTCGA-KS-A41I-11APCBP2chr12

53873467

+CDS2chr20

5177892

+


Top

Fusion Gene ORF analysis for PCBP2-CDS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000359282ENST00000460006PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-3UTRENST00000359282ENST00000460006PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-3UTRENST00000359462ENST00000460006PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-3UTRENST00000359462ENST00000460006PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-3UTRENST00000437231ENST00000460006PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-3UTRENST00000437231ENST00000460006PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-3UTRENST00000447282ENST00000460006PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-3UTRENST00000447282ENST00000460006PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-3UTRENST00000455667ENST00000460006PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-3UTRENST00000455667ENST00000460006PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-3UTRENST00000546463ENST00000460006PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-3UTRENST00000549863ENST00000460006PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-3UTRENST00000549863ENST00000460006PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-3UTRENST00000552819ENST00000460006PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-3UTRENST00000552819ENST00000460006PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-3UTRENST00000603815ENST00000460006PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-3UTRENST00000603815ENST00000460006PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000359282ENST00000379062PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000359282ENST00000379062PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000359282ENST00000379070PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000359282ENST00000379070PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000359282ENST00000535100PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000359282ENST00000535100PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000359462ENST00000379062PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000359462ENST00000379062PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000359462ENST00000379070PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000359462ENST00000379070PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000359462ENST00000535100PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000359462ENST00000535100PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000437231ENST00000379062PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000437231ENST00000379062PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000437231ENST00000379070PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000437231ENST00000379070PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000437231ENST00000535100PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000437231ENST00000535100PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000447282ENST00000379062PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000447282ENST00000379062PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000447282ENST00000379070PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000447282ENST00000379070PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000447282ENST00000535100PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000447282ENST00000535100PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000455667ENST00000379062PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000455667ENST00000379062PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000455667ENST00000379070PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000455667ENST00000379070PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000455667ENST00000535100PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000455667ENST00000535100PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000546463ENST00000379062PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000546463ENST00000379070PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000546463ENST00000535100PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000549863ENST00000379062PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000549863ENST00000379062PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000549863ENST00000379070PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000549863ENST00000379070PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000549863ENST00000535100PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000549863ENST00000535100PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000552819ENST00000379062PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000552819ENST00000379062PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000552819ENST00000379070PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000552819ENST00000379070PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000552819ENST00000535100PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000552819ENST00000535100PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000603815ENST00000379062PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000603815ENST00000379062PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000603815ENST00000379070PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000603815ENST00000379070PCBP2chr12

53873452

+CDS2chr20

5177877

+
3UTR-intronENST00000603815ENST00000535100PCBP2chr12

53873467

+CDS2chr20

5177892

+
3UTR-intronENST00000603815ENST00000535100PCBP2chr12

53873452

+CDS2chr20

5177877

+
5CDS-3UTRENST00000546463ENST00000460006PCBP2chr12

53873467

+CDS2chr20

5177892

+
5CDS-intronENST00000546463ENST00000379062PCBP2chr12

53873467

+CDS2chr20

5177892

+
5CDS-intronENST00000546463ENST00000379070PCBP2chr12

53873467

+CDS2chr20

5177892

+
5CDS-intronENST00000546463ENST00000535100PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-3UTRENST00000439930ENST00000460006PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-3UTRENST00000439930ENST00000460006PCBP2chr12

53873452

+CDS2chr20

5177877

+
intron-3UTRENST00000541275ENST00000460006PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-3UTRENST00000541275ENST00000460006PCBP2chr12

53873452

+CDS2chr20

5177877

+
intron-3UTRENST00000548933ENST00000460006PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-3UTRENST00000548933ENST00000460006PCBP2chr12

53873452

+CDS2chr20

5177877

+
intron-3UTRENST00000552296ENST00000460006PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-3UTRENST00000552296ENST00000460006PCBP2chr12

53873452

+CDS2chr20

5177877

+
intron-intronENST00000439930ENST00000379062PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-intronENST00000439930ENST00000379062PCBP2chr12

53873452

+CDS2chr20

5177877

+
intron-intronENST00000439930ENST00000379070PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-intronENST00000439930ENST00000379070PCBP2chr12

53873452

+CDS2chr20

5177877

+
intron-intronENST00000439930ENST00000535100PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-intronENST00000439930ENST00000535100PCBP2chr12

53873452

+CDS2chr20

5177877

+
intron-intronENST00000541275ENST00000379062PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-intronENST00000541275ENST00000379062PCBP2chr12

53873452

+CDS2chr20

5177877

+
intron-intronENST00000541275ENST00000379070PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-intronENST00000541275ENST00000379070PCBP2chr12

53873452

+CDS2chr20

5177877

+
intron-intronENST00000541275ENST00000535100PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-intronENST00000541275ENST00000535100PCBP2chr12

53873452

+CDS2chr20

5177877

+
intron-intronENST00000548933ENST00000379062PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-intronENST00000548933ENST00000379062PCBP2chr12

53873452

+CDS2chr20

5177877

+
intron-intronENST00000548933ENST00000379070PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-intronENST00000548933ENST00000379070PCBP2chr12

53873452

+CDS2chr20

5177877

+
intron-intronENST00000548933ENST00000535100PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-intronENST00000548933ENST00000535100PCBP2chr12

53873452

+CDS2chr20

5177877

+
intron-intronENST00000552296ENST00000379062PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-intronENST00000552296ENST00000379062PCBP2chr12

53873452

+CDS2chr20

5177877

+
intron-intronENST00000552296ENST00000379070PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-intronENST00000552296ENST00000379070PCBP2chr12

53873452

+CDS2chr20

5177877

+
intron-intronENST00000552296ENST00000535100PCBP2chr12

53873467

+CDS2chr20

5177892

+
intron-intronENST00000552296ENST00000535100PCBP2chr12

53873452

+CDS2chr20

5177877

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for PCBP2-CDS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


Top

Fusion Protein Features for PCBP2-CDS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:53873467/:5177892)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDS2

O95674

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (PubMed:25375833). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). {ECO:0000269|PubMed:25375833, ECO:0000269|PubMed:26946540, ECO:0000269|PubMed:31548309}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PCBP2-CDS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for PCBP2-CDS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PCBP2-CDS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PCBP2-CDS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource