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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATP5C1-ALDH7A1 (FusionGDB2 ID:HG509TG501)

Fusion Gene Summary for ATP5C1-ALDH7A1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP5C1-ALDH7A1
Fusion gene ID: hg509tg501
HgeneTgene
Gene symbol

ATP5C1

ALDH7A1

Gene ID

509

501

Gene nameATP synthase F1 subunit gammaaldehyde dehydrogenase 7 family member A1
SynonymsATP5C|ATP5C1|ATP5CL1ATQ1|EPD|PDE
Cytomap('ATP5C1')('ALDH7A1')

10p14

5q23.2

Type of geneprotein-codingprotein-coding
DescriptionATP synthase subunit gamma, mitochondrialATP synthase gamma chain, mitochondrialATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1F-ATPase gamma subunitmitochondrial ATP synthase, gamma subunit 1alpha-aminoadipic semialdehyde dehydrogenase26g turgor protein homologP6c dehydrogenasealpha-AASA dehydrogenaseantiquitin-1betaine aldehyde dehydrogenasedelta1-piperideine-6-carboxylate dehydrogenaseepididymis secretory sperm binding protein
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000335698, ENST00000356708, 
ENST00000493053, ENST00000541227, 
Fusion gene scores* DoF score10 X 8 X 7=5603 X 3 X 2=18
# samples 113
** MAII scorelog2(11/560*10)=-2.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATP5C1 [Title/Abstract] AND ALDH7A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP5C1(7838118)-ALDH7A1(125896816), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP5C1

GO:0042776

mitochondrial ATP synthesis coupled proton transport

12110673


check buttonFusion gene breakpoints across ATP5C1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ALDH7A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315399ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-


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Fusion Gene ORF analysis for ATP5C1-ALDH7A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000335698ENST00000413020ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-
5CDS-intronENST00000356708ENST00000413020ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-
In-frameENST00000335698ENST00000409134ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-
In-frameENST00000335698ENST00000447989ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-
In-frameENST00000335698ENST00000553117ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-
In-frameENST00000356708ENST00000409134ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-
In-frameENST00000356708ENST00000447989ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-
In-frameENST00000356708ENST00000553117ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-
intron-3CDSENST00000493053ENST00000409134ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-
intron-3CDSENST00000493053ENST00000447989ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-
intron-3CDSENST00000493053ENST00000553117ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-
intron-3CDSENST00000541227ENST00000409134ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-
intron-3CDSENST00000541227ENST00000447989ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-
intron-3CDSENST00000541227ENST00000553117ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-
intron-intronENST00000493053ENST00000413020ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-
intron-intronENST00000541227ENST00000413020ATP5C1chr10

7838118

+ALDH7A1chr5

125896816

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356708ATP5C1chr107838118+ENST00000409134ALDH7A1chr5125896816-404317079918279
ENST00000356708ATP5C1chr107838118+ENST00000447989ALDH7A1chr5125896816-109617079726215
ENST00000356708ATP5C1chr107838118+ENST00000553117ALDH7A1chr5125896816-109617079726215
ENST00000335698ATP5C1chr107838118+ENST00000409134ALDH7A1chr5125896816-399512231870279
ENST00000335698ATP5C1chr107838118+ENST00000447989ALDH7A1chr5125896816-104812231678215
ENST00000335698ATP5C1chr107838118+ENST00000553117ALDH7A1chr5125896816-104812231678215

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356708ENST00000409134ATP5C1chr107838118+ALDH7A1chr5125896816-0.000563860.9994361
ENST00000356708ENST00000447989ATP5C1chr107838118+ALDH7A1chr5125896816-0.0034065150.9965934
ENST00000356708ENST00000553117ATP5C1chr107838118+ALDH7A1chr5125896816-0.0034065150.9965934
ENST00000335698ENST00000409134ATP5C1chr107838118+ALDH7A1chr5125896816-0.0005528390.99944717
ENST00000335698ENST00000447989ATP5C1chr107838118+ALDH7A1chr5125896816-0.0033530710.99664694
ENST00000335698ENST00000553117ATP5C1chr107838118+ALDH7A1chr5125896816-0.0033530710.99664694

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Fusion Genomic Features for ATP5C1-ALDH7A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ATP5C1-ALDH7A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:7838118/chr5:125896816)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneALDH7A1chr10:7838118chr5:125896816ENST00000409134818274_279290540.0Nucleotide bindingNAD
TgeneALDH7A1chr10:7838118chr5:125896816ENST00000447989816274_279317503.0Nucleotide bindingNAD


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Fusion Gene Sequence for ATP5C1-ALDH7A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7944_7944_1_ATP5C1-ALDH7A1_ATP5C1_chr10_7838118_ENST00000335698_ALDH7A1_chr5_125896816_ENST00000409134_length(transcript)=3995nt_BP=122nt
CTGACCGACCTTCAGCAGGGCTGTGGCTACCATGTTCTCTCGCGCGGGTGTCGCTGGGCTGTCGGCCTGGACCTTGCAGCCGCAATGGAT
TCAAGTTCGAAATATGGCAACTTTGAAAGATAGGAGAAGTCTGTTGGAACTTGGAGGAAACAATGCCATTATTGCCTTTGAAGATGCAGA
CCTCAGCTTAGTTGTTCCATCAGCTCTCTTCGCTGCTGTGGGAACAGCTGGCCAGAGGTGTACCACTGCGAGGCGACTGTTTATACATGA
AAGCATCCATGATGAGGTTGTAAACAGACTTAAAAAGGCCTATGCACAGATCCGAGTTGGGAACCCATGGGACCCTAATGTTCTCTATGG
GCCACTCCACACCAAGCAGGCAGTGAGCATGTTTCTTGGAGCAGTGGAAGAAGCAAAGAAAGAAGGTGGCACAGTGGTCTATGGGGGCAA
GGTTATGGATCGCCCTGGAAATTATGTAGAACCGACAATTGTGACAGGTCTTGGCCACGATGCGTCCATTGCACACACAGAGACTTTTGC
TCCGATTCTCTATGTCTTTAAATTCAAGAATGAAGAAGAGGTCTTTGCATGGAATAATGAAGTAAAACAGGGACTTTCAAGTAGCATCTT
TACCAAAGATCTGGGCAGAATCTTTCGCTGGCTTGGACCTAAAGGATCAGACTGTGGCATTGTAAATGTCAACATTCCAACAAGTGGGGC
TGAGATTGGAGGTGCCTTTGGAGGAGAAAAGCACACTGGTGGTGGCAGGGAGTCTGGCAGTGATGCCTGGAAACAGTACATGAGAAGGTC
TACTTGTACTATCAACTACAGTAAAGACCTTCCTCTGGCCCAAGGAATCAAGTTTCAGTAAAGGTGTTTTAGATGAACATCCCTTAATTT
GAGGTGTTCCAGCAGCTGTTTTTGGAGAAGACAAAGAAAATTAAAGTTTTCCCTGAATAAATGCATTATTATGACTGTGACAGTGACTAA
TCCCCCTATGACCCCAAAGCCCTGATTAAATCAAGAGATTCCTTTTTTAAAAATCAAAATAAAATTGTTACAACATAGCCATAGTTACTA
AAAGATGAGTTAGGTGGATTTTTATTATGTCAACTAGTTGTACATGGCTTTTTAAAAGTTAATGATTATTTTGTAATTAGAAAAAAATAG
TACGTACCAGGGTAGGAATTTGGGAAAATACAGAACCGAGGAGAAAACAGAAGTCTTTGCAGTAGATACAGGGTGTCTCCTGACCAAGTG
AAGGATTCAGGGGCGGGGGGTGAATATTGCTTGACATTACCCACCTATGGCATGTGTTGGATGTCGTGTGATTGAAAGGGGGATGCATTC
CCCTGTATGCTTGGACCACAGTTCAGTATTCATGTGGAATAACTTGCAGTGCTTAAAATGACAACAGGCATTCATCACAGTTATGGCTCT
TGCTTATGAAGGCTGTGTCAACTTGGAAGAGATTTCTGGGGTAGACAGATTTTGTTCCTGTGCTGGAGTCTGCCACCTGCTGGAGGACTC
TGAGGCCAAAATTGCCCGTGCAGAGTTGTATAGAAAATGCGTCTGGAGGCTGGGCAAGGTGGCTTACGCCTATAATCCCAGCACTTTGAG
AGGCCGAGGCGGGTGGATCAGTAGAGGCTAGGAGTTTGAGACCAGCCTGGCCGATATCGTGAAACCCCGTCTTTACCAAAAAATACAAAA
ATTAGCCCAGTGTGGTGGCAGGCACCTGTAATCCCAGCTATTAGGGAGGCTGAGGCAGGAGAATTGTGTGAACCCAGGAGGCAGAGGTTG
CAGTGAGCCTAGATTGTGCCACTGCCTGGGCAACAGTGAGATCCTGTCTACAAAAAAAAAAAAAAAAAAAAGTGCATCTGGATTTTTTTA
TACAACCTTAGACCACCTTCTTTAGCTTTAGGCGTCTGCGGTTGCCCTTGGATCTGTTCTCAATCCTCAGTGTGTGTGGCAGCATGTGGT
CATAGAGAGCTGGGCAAAGTTCACTTTCTCTTTGCTGACAGTCTCACCTTTTCTCACTGGGAAGCTGCACAGGAGCCTTTGGGCTGGTTC
AGCCCAGAGGCCCCTGTTCTCCTGCCTTCCTGGCATTCTCTGCTCCCCTTCTGCATGGCACCCCTCTACTCCTGCCAGGTTAGAATGGAG
CAGAGGCCTTTGAACAAGATGACATTTGTAGACAACCTGATCCATCAGGATGTGGAGAGATCTGGACAAATGGCAAATAATTTGGGGTTG
AATTATGGCCCAGAGAAGTAAGCAAATGAAAAACTAAACAATTATAAATGTATCTGGGAAGCAAAGGTATTCATAATATGTCCCATGGCC
AGCTGCGAGCAGTATTTAACTAGACATGCTGTTGTCAATATTGAACATGAATCAAGCCAAATACTGATATAGCTATTGAGAGAAGGTTGG
CAGGAAGAAATCATGGGTGAGGGTATGTGGGAGTGATAATCTTAGCTATAGATTTTAGGTAAAACTGATTCTGAAAGCTTTCTTTGAAAC
AAATTTATAATTTTTCTTCTACATGTTTCTAGCACAAGGACTCAATTTTTTTTGGTTATAATGTTCATTAAAACATATGCCTTCAATTTG
TTCCTCTTTGTTCTTTTTTGCTGATTTAGCAGATATAAATCACTTGTTAGTATTTTTAACTATCCAAGTTAAAATGTACATTTGTAAGTG
TTATTACTGGTCTTATATTTGAAGGTGCAAGGGGTCTTGTGCTGCTCATTACTGGTTATCTTGAGCATTTCATAACTGCTGCCTCCTCCT
AAATCCTGTGTTCCAACCGCTACTGCTGGCAATGCCCAGCCTCCATTGTGGATGCGGGGAATTGTGTTCAGCATGCTTGCTTCTGCCACG
GCACTAAAGCCTAACTTGCTTAGGATCTTGCTGTACTTGGAGAGAGCATCCATTCGCTGAGCCTAGCAGCCAGGCTCTTGTGACTCCCTG
GGAAGTGGGTGAAGACCTGGCTCCTGGCTGCAGCAGTGAGGAGGCAGGCCCTCCAGGTGAAGACTTCTCACAATGGAGGGAAGGCAGTTT
TCTCAAAGGAAATTGAGTGCTATTATGTACTCTGCTTCCTACTTTCTCTTTCAGGGTGGGAATCTGTTAAGCCTCCTCTCTCTCTTGCTC
TGCAACCACAGAACACTTCTTTTTTTTTGGTGTCTCAGTTTTGCCCACACTGGAGTGCAGTGGTGCAATAGTGGCTCACTGCAGCCTCCA
ACTCCTGGGCTCAATCTATCCTTCCACCTCATGCTCCCCAGTAGCTGGGACTACAGGTGCATGCCACTGTGCCCAGCTGATTATTATTTT
TTTTTGTAAAGATTGGGTCATACTACATTGCTCATGCTCGTCTTGAACTTGTGGCCTCAAGCGATCCTCCTGCCTCAGCCTCTTGAGTTG
TTGGGATTACAGGAGTGTGCCACCATGCCCAGCTCTGTGGAAAATTCTCTGTGGCATTCTGTCTCCTGAAAATGCTGAAGGGACCAAGAG
GGCTCTGTGTCCTTCCTCTTCTCTTCCCTGGCACTTTCAGACCATTTTCTTGTTGCCTTCATTCTAACAAAGGTTGCAGATTGGAAAGCT
GATTTGGAATGCTTTTTAAGTGTTTTCAGTTTCAATATTTTTATGAAATTCCTATGGTCTCCAACAAACTTTTTTTTTTTTTTTTTTTTC
TACACCTGGAGCTTATCCTGCAGAAGCTTCCTGCCAATGATTGTTTTGGAGGAAATTAAAAGAAAACCAAACGAAACCTCTCCTATCCAA
GGGGAAGAACTTTATCCCCATATTGATTGAATATAGGATTCTAGATTTAAAATGTTGTAGGCAGTTAGAGTTTGCTCTTTTTTTTTTTCT
ATTGGAAAGGTCCACAAATGTTTTATTGACATTTTTGTCTTTAATCCATTTGGATTTGGGGTACATGTTACGATTTGTCTACGTTAATTT

>7944_7944_1_ATP5C1-ALDH7A1_ATP5C1_chr10_7838118_ENST00000335698_ALDH7A1_chr5_125896816_ENST00000409134_length(amino acids)=279AA_BP=31
MFSRAGVAGLSAWTLQPQWIQVRNMATLKDRRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRL
KKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKN
EEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSKDL

--------------------------------------------------------------
>7944_7944_2_ATP5C1-ALDH7A1_ATP5C1_chr10_7838118_ENST00000335698_ALDH7A1_chr5_125896816_ENST00000447989_length(transcript)=1048nt_BP=122nt
CTGACCGACCTTCAGCAGGGCTGTGGCTACCATGTTCTCTCGCGCGGGTGTCGCTGGGCTGTCGGCCTGGACCTTGCAGCCGCAATGGAT
TCAAGTTCGAAATATGGCAACTTTGAAAGATAGGAGAAGTCTGTTGGAACTTGGAGGAAACAATGCCATTATTGCCTTTGAAGATGCAGA
CCTCAGCTTAGTTGTTCCATCAGCTCTCTTCGCTGCTGTGGGAACAGCTGGCCAGAGGTGTACCACTGCGAGGCGACTGGTTATGGATCG
CCCTGGAAATTATGTAGAACCGACAATTGTGACAGGTCTTGGCCACGATGCGTCCATTGCACACACAGAGACTTTTGCTCCGATTCTCTA
TGTCTTTAAATTCAAGAATGAAGAAGAGGTCTTTGCATGGAATAATGAAGTAAAACAGGGACTTTCAAGTAGCATCTTTACCAAAGATCT
GGGCAGAATCTTTCGCTGGCTTGGACCTAAAGGATCAGACTGTGGCATTGTAAATGTCAACATTCCAACAAGTGGGGCTGAGATTGGAGG
TGCCTTTGGAGGAGAAAAGCACACTGGTGGTGGCAGGGAGTCTGGCAGTGATGCCTGGAAACAGTACATGAGAAGGTCTACTTGTACTAT
CAACTACAGTAAAGACCTTCCTCTGGCCCAAGGAATCAAGTTTCAGTAAAGGTGTTTTAGATGAACATCCCTTAATTTGAGGTGTTCCAG
CAGCTGTTTTTGGAGAAGACAAAGAAAATTAAAGTTTTCCCTGAATAAATGCATTATTATGACTGTGACAGTGACTAATCCCCCTATGAC
CCCAAAGCCCTGATTAAATCAAGAGATTCCTTTTTTAAAAATCAAAATAAAATTGTTACAACATAGCCATAGTTACTAAAAGATGAGTTA
GGTGGATTTTTATTATGTCAACTAGTTGTACATGGCTTTTTAAAAGTTAATGATTATTTTGTAATTAGAAAAAAATAGTACGTACCAGGG

>7944_7944_2_ATP5C1-ALDH7A1_ATP5C1_chr10_7838118_ENST00000335698_ALDH7A1_chr5_125896816_ENST00000447989_length(amino acids)=215AA_BP=31
MFSRAGVAGLSAWTLQPQWIQVRNMATLKDRRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLVMDRPGNYVEPTIV
TGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGG

--------------------------------------------------------------
>7944_7944_3_ATP5C1-ALDH7A1_ATP5C1_chr10_7838118_ENST00000335698_ALDH7A1_chr5_125896816_ENST00000553117_length(transcript)=1048nt_BP=122nt
CTGACCGACCTTCAGCAGGGCTGTGGCTACCATGTTCTCTCGCGCGGGTGTCGCTGGGCTGTCGGCCTGGACCTTGCAGCCGCAATGGAT
TCAAGTTCGAAATATGGCAACTTTGAAAGATAGGAGAAGTCTGTTGGAACTTGGAGGAAACAATGCCATTATTGCCTTTGAAGATGCAGA
CCTCAGCTTAGTTGTTCCATCAGCTCTCTTCGCTGCTGTGGGAACAGCTGGCCAGAGGTGTACCACTGCGAGGCGACTGGTTATGGATCG
CCCTGGAAATTATGTAGAACCGACAATTGTGACAGGTCTTGGCCACGATGCGTCCATTGCACACACAGAGACTTTTGCTCCGATTCTCTA
TGTCTTTAAATTCAAGAATGAAGAAGAGGTCTTTGCATGGAATAATGAAGTAAAACAGGGACTTTCAAGTAGCATCTTTACCAAAGATCT
GGGCAGAATCTTTCGCTGGCTTGGACCTAAAGGATCAGACTGTGGCATTGTAAATGTCAACATTCCAACAAGTGGGGCTGAGATTGGAGG
TGCCTTTGGAGGAGAAAAGCACACTGGTGGTGGCAGGGAGTCTGGCAGTGATGCCTGGAAACAGTACATGAGAAGGTCTACTTGTACTAT
CAACTACAGTAAAGACCTTCCTCTGGCCCAAGGAATCAAGTTTCAGTAAAGGTGTTTTAGATGAACATCCCTTAATTTGAGGTGTTCCAG
CAGCTGTTTTTGGAGAAGACAAAGAAAATTAAAGTTTTCCCTGAATAAATGCATTATTATGACTGTGACAGTGACTAATCCCCCTATGAC
CCCAAAGCCCTGATTAAATCAAGAGATTCCTTTTTTAAAAATCAAAATAAAATTGTTACAACATAGCCATAGTTACTAAAAGATGAGTTA
GGTGGATTTTTATTATGTCAACTAGTTGTACATGGCTTTTTAAAAGTTAATGATTATTTTGTAATTAGAAAAAAATAGTACGTACCAGGG

>7944_7944_3_ATP5C1-ALDH7A1_ATP5C1_chr10_7838118_ENST00000335698_ALDH7A1_chr5_125896816_ENST00000553117_length(amino acids)=215AA_BP=31
MFSRAGVAGLSAWTLQPQWIQVRNMATLKDRRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLVMDRPGNYVEPTIV
TGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGG

--------------------------------------------------------------
>7944_7944_4_ATP5C1-ALDH7A1_ATP5C1_chr10_7838118_ENST00000356708_ALDH7A1_chr5_125896816_ENST00000409134_length(transcript)=4043nt_BP=170nt
TGGGAGGGGCGCGCTGGGGAGCTTCGGCGCATGCGCGCTGAGGCCTGCCTGACCGACCTTCAGCAGGGCTGTGGCTACCATGTTCTCTCG
CGCGGGTGTCGCTGGGCTGTCGGCCTGGACCTTGCAGCCGCAATGGATTCAAGTTCGAAATATGGCAACTTTGAAAGATAGGAGAAGTCT
GTTGGAACTTGGAGGAAACAATGCCATTATTGCCTTTGAAGATGCAGACCTCAGCTTAGTTGTTCCATCAGCTCTCTTCGCTGCTGTGGG
AACAGCTGGCCAGAGGTGTACCACTGCGAGGCGACTGTTTATACATGAAAGCATCCATGATGAGGTTGTAAACAGACTTAAAAAGGCCTA
TGCACAGATCCGAGTTGGGAACCCATGGGACCCTAATGTTCTCTATGGGCCACTCCACACCAAGCAGGCAGTGAGCATGTTTCTTGGAGC
AGTGGAAGAAGCAAAGAAAGAAGGTGGCACAGTGGTCTATGGGGGCAAGGTTATGGATCGCCCTGGAAATTATGTAGAACCGACAATTGT
GACAGGTCTTGGCCACGATGCGTCCATTGCACACACAGAGACTTTTGCTCCGATTCTCTATGTCTTTAAATTCAAGAATGAAGAAGAGGT
CTTTGCATGGAATAATGAAGTAAAACAGGGACTTTCAAGTAGCATCTTTACCAAAGATCTGGGCAGAATCTTTCGCTGGCTTGGACCTAA
AGGATCAGACTGTGGCATTGTAAATGTCAACATTCCAACAAGTGGGGCTGAGATTGGAGGTGCCTTTGGAGGAGAAAAGCACACTGGTGG
TGGCAGGGAGTCTGGCAGTGATGCCTGGAAACAGTACATGAGAAGGTCTACTTGTACTATCAACTACAGTAAAGACCTTCCTCTGGCCCA
AGGAATCAAGTTTCAGTAAAGGTGTTTTAGATGAACATCCCTTAATTTGAGGTGTTCCAGCAGCTGTTTTTGGAGAAGACAAAGAAAATT
AAAGTTTTCCCTGAATAAATGCATTATTATGACTGTGACAGTGACTAATCCCCCTATGACCCCAAAGCCCTGATTAAATCAAGAGATTCC
TTTTTTAAAAATCAAAATAAAATTGTTACAACATAGCCATAGTTACTAAAAGATGAGTTAGGTGGATTTTTATTATGTCAACTAGTTGTA
CATGGCTTTTTAAAAGTTAATGATTATTTTGTAATTAGAAAAAAATAGTACGTACCAGGGTAGGAATTTGGGAAAATACAGAACCGAGGA
GAAAACAGAAGTCTTTGCAGTAGATACAGGGTGTCTCCTGACCAAGTGAAGGATTCAGGGGCGGGGGGTGAATATTGCTTGACATTACCC
ACCTATGGCATGTGTTGGATGTCGTGTGATTGAAAGGGGGATGCATTCCCCTGTATGCTTGGACCACAGTTCAGTATTCATGTGGAATAA
CTTGCAGTGCTTAAAATGACAACAGGCATTCATCACAGTTATGGCTCTTGCTTATGAAGGCTGTGTCAACTTGGAAGAGATTTCTGGGGT
AGACAGATTTTGTTCCTGTGCTGGAGTCTGCCACCTGCTGGAGGACTCTGAGGCCAAAATTGCCCGTGCAGAGTTGTATAGAAAATGCGT
CTGGAGGCTGGGCAAGGTGGCTTACGCCTATAATCCCAGCACTTTGAGAGGCCGAGGCGGGTGGATCAGTAGAGGCTAGGAGTTTGAGAC
CAGCCTGGCCGATATCGTGAAACCCCGTCTTTACCAAAAAATACAAAAATTAGCCCAGTGTGGTGGCAGGCACCTGTAATCCCAGCTATT
AGGGAGGCTGAGGCAGGAGAATTGTGTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCTAGATTGTGCCACTGCCTGGGCAACAGTGAGAT
CCTGTCTACAAAAAAAAAAAAAAAAAAAAGTGCATCTGGATTTTTTTATACAACCTTAGACCACCTTCTTTAGCTTTAGGCGTCTGCGGT
TGCCCTTGGATCTGTTCTCAATCCTCAGTGTGTGTGGCAGCATGTGGTCATAGAGAGCTGGGCAAAGTTCACTTTCTCTTTGCTGACAGT
CTCACCTTTTCTCACTGGGAAGCTGCACAGGAGCCTTTGGGCTGGTTCAGCCCAGAGGCCCCTGTTCTCCTGCCTTCCTGGCATTCTCTG
CTCCCCTTCTGCATGGCACCCCTCTACTCCTGCCAGGTTAGAATGGAGCAGAGGCCTTTGAACAAGATGACATTTGTAGACAACCTGATC
CATCAGGATGTGGAGAGATCTGGACAAATGGCAAATAATTTGGGGTTGAATTATGGCCCAGAGAAGTAAGCAAATGAAAAACTAAACAAT
TATAAATGTATCTGGGAAGCAAAGGTATTCATAATATGTCCCATGGCCAGCTGCGAGCAGTATTTAACTAGACATGCTGTTGTCAATATT
GAACATGAATCAAGCCAAATACTGATATAGCTATTGAGAGAAGGTTGGCAGGAAGAAATCATGGGTGAGGGTATGTGGGAGTGATAATCT
TAGCTATAGATTTTAGGTAAAACTGATTCTGAAAGCTTTCTTTGAAACAAATTTATAATTTTTCTTCTACATGTTTCTAGCACAAGGACT
CAATTTTTTTTGGTTATAATGTTCATTAAAACATATGCCTTCAATTTGTTCCTCTTTGTTCTTTTTTGCTGATTTAGCAGATATAAATCA
CTTGTTAGTATTTTTAACTATCCAAGTTAAAATGTACATTTGTAAGTGTTATTACTGGTCTTATATTTGAAGGTGCAAGGGGTCTTGTGC
TGCTCATTACTGGTTATCTTGAGCATTTCATAACTGCTGCCTCCTCCTAAATCCTGTGTTCCAACCGCTACTGCTGGCAATGCCCAGCCT
CCATTGTGGATGCGGGGAATTGTGTTCAGCATGCTTGCTTCTGCCACGGCACTAAAGCCTAACTTGCTTAGGATCTTGCTGTACTTGGAG
AGAGCATCCATTCGCTGAGCCTAGCAGCCAGGCTCTTGTGACTCCCTGGGAAGTGGGTGAAGACCTGGCTCCTGGCTGCAGCAGTGAGGA
GGCAGGCCCTCCAGGTGAAGACTTCTCACAATGGAGGGAAGGCAGTTTTCTCAAAGGAAATTGAGTGCTATTATGTACTCTGCTTCCTAC
TTTCTCTTTCAGGGTGGGAATCTGTTAAGCCTCCTCTCTCTCTTGCTCTGCAACCACAGAACACTTCTTTTTTTTTGGTGTCTCAGTTTT
GCCCACACTGGAGTGCAGTGGTGCAATAGTGGCTCACTGCAGCCTCCAACTCCTGGGCTCAATCTATCCTTCCACCTCATGCTCCCCAGT
AGCTGGGACTACAGGTGCATGCCACTGTGCCCAGCTGATTATTATTTTTTTTTGTAAAGATTGGGTCATACTACATTGCTCATGCTCGTC
TTGAACTTGTGGCCTCAAGCGATCCTCCTGCCTCAGCCTCTTGAGTTGTTGGGATTACAGGAGTGTGCCACCATGCCCAGCTCTGTGGAA
AATTCTCTGTGGCATTCTGTCTCCTGAAAATGCTGAAGGGACCAAGAGGGCTCTGTGTCCTTCCTCTTCTCTTCCCTGGCACTTTCAGAC
CATTTTCTTGTTGCCTTCATTCTAACAAAGGTTGCAGATTGGAAAGCTGATTTGGAATGCTTTTTAAGTGTTTTCAGTTTCAATATTTTT
ATGAAATTCCTATGGTCTCCAACAAACTTTTTTTTTTTTTTTTTTTTCTACACCTGGAGCTTATCCTGCAGAAGCTTCCTGCCAATGATT
GTTTTGGAGGAAATTAAAAGAAAACCAAACGAAACCTCTCCTATCCAAGGGGAAGAACTTTATCCCCATATTGATTGAATATAGGATTCT
AGATTTAAAATGTTGTAGGCAGTTAGAGTTTGCTCTTTTTTTTTTTCTATTGGAAAGGTCCACAAATGTTTTATTGACATTTTTGTCTTT

>7944_7944_4_ATP5C1-ALDH7A1_ATP5C1_chr10_7838118_ENST00000356708_ALDH7A1_chr5_125896816_ENST00000409134_length(amino acids)=279AA_BP=31
MFSRAGVAGLSAWTLQPQWIQVRNMATLKDRRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRL
KKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKN
EEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSKDL

--------------------------------------------------------------
>7944_7944_5_ATP5C1-ALDH7A1_ATP5C1_chr10_7838118_ENST00000356708_ALDH7A1_chr5_125896816_ENST00000447989_length(transcript)=1096nt_BP=170nt
TGGGAGGGGCGCGCTGGGGAGCTTCGGCGCATGCGCGCTGAGGCCTGCCTGACCGACCTTCAGCAGGGCTGTGGCTACCATGTTCTCTCG
CGCGGGTGTCGCTGGGCTGTCGGCCTGGACCTTGCAGCCGCAATGGATTCAAGTTCGAAATATGGCAACTTTGAAAGATAGGAGAAGTCT
GTTGGAACTTGGAGGAAACAATGCCATTATTGCCTTTGAAGATGCAGACCTCAGCTTAGTTGTTCCATCAGCTCTCTTCGCTGCTGTGGG
AACAGCTGGCCAGAGGTGTACCACTGCGAGGCGACTGGTTATGGATCGCCCTGGAAATTATGTAGAACCGACAATTGTGACAGGTCTTGG
CCACGATGCGTCCATTGCACACACAGAGACTTTTGCTCCGATTCTCTATGTCTTTAAATTCAAGAATGAAGAAGAGGTCTTTGCATGGAA
TAATGAAGTAAAACAGGGACTTTCAAGTAGCATCTTTACCAAAGATCTGGGCAGAATCTTTCGCTGGCTTGGACCTAAAGGATCAGACTG
TGGCATTGTAAATGTCAACATTCCAACAAGTGGGGCTGAGATTGGAGGTGCCTTTGGAGGAGAAAAGCACACTGGTGGTGGCAGGGAGTC
TGGCAGTGATGCCTGGAAACAGTACATGAGAAGGTCTACTTGTACTATCAACTACAGTAAAGACCTTCCTCTGGCCCAAGGAATCAAGTT
TCAGTAAAGGTGTTTTAGATGAACATCCCTTAATTTGAGGTGTTCCAGCAGCTGTTTTTGGAGAAGACAAAGAAAATTAAAGTTTTCCCT
GAATAAATGCATTATTATGACTGTGACAGTGACTAATCCCCCTATGACCCCAAAGCCCTGATTAAATCAAGAGATTCCTTTTTTAAAAAT
CAAAATAAAATTGTTACAACATAGCCATAGTTACTAAAAGATGAGTTAGGTGGATTTTTATTATGTCAACTAGTTGTACATGGCTTTTTA
AAAGTTAATGATTATTTTGTAATTAGAAAAAAATAGTACGTACCAGGGTAGGAATTTGGGAAAATACAGAACCGAGGAGAAAACAGAAGT

>7944_7944_5_ATP5C1-ALDH7A1_ATP5C1_chr10_7838118_ENST00000356708_ALDH7A1_chr5_125896816_ENST00000447989_length(amino acids)=215AA_BP=31
MFSRAGVAGLSAWTLQPQWIQVRNMATLKDRRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLVMDRPGNYVEPTIV
TGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGG

--------------------------------------------------------------
>7944_7944_6_ATP5C1-ALDH7A1_ATP5C1_chr10_7838118_ENST00000356708_ALDH7A1_chr5_125896816_ENST00000553117_length(transcript)=1096nt_BP=170nt
TGGGAGGGGCGCGCTGGGGAGCTTCGGCGCATGCGCGCTGAGGCCTGCCTGACCGACCTTCAGCAGGGCTGTGGCTACCATGTTCTCTCG
CGCGGGTGTCGCTGGGCTGTCGGCCTGGACCTTGCAGCCGCAATGGATTCAAGTTCGAAATATGGCAACTTTGAAAGATAGGAGAAGTCT
GTTGGAACTTGGAGGAAACAATGCCATTATTGCCTTTGAAGATGCAGACCTCAGCTTAGTTGTTCCATCAGCTCTCTTCGCTGCTGTGGG
AACAGCTGGCCAGAGGTGTACCACTGCGAGGCGACTGGTTATGGATCGCCCTGGAAATTATGTAGAACCGACAATTGTGACAGGTCTTGG
CCACGATGCGTCCATTGCACACACAGAGACTTTTGCTCCGATTCTCTATGTCTTTAAATTCAAGAATGAAGAAGAGGTCTTTGCATGGAA
TAATGAAGTAAAACAGGGACTTTCAAGTAGCATCTTTACCAAAGATCTGGGCAGAATCTTTCGCTGGCTTGGACCTAAAGGATCAGACTG
TGGCATTGTAAATGTCAACATTCCAACAAGTGGGGCTGAGATTGGAGGTGCCTTTGGAGGAGAAAAGCACACTGGTGGTGGCAGGGAGTC
TGGCAGTGATGCCTGGAAACAGTACATGAGAAGGTCTACTTGTACTATCAACTACAGTAAAGACCTTCCTCTGGCCCAAGGAATCAAGTT
TCAGTAAAGGTGTTTTAGATGAACATCCCTTAATTTGAGGTGTTCCAGCAGCTGTTTTTGGAGAAGACAAAGAAAATTAAAGTTTTCCCT
GAATAAATGCATTATTATGACTGTGACAGTGACTAATCCCCCTATGACCCCAAAGCCCTGATTAAATCAAGAGATTCCTTTTTTAAAAAT
CAAAATAAAATTGTTACAACATAGCCATAGTTACTAAAAGATGAGTTAGGTGGATTTTTATTATGTCAACTAGTTGTACATGGCTTTTTA
AAAGTTAATGATTATTTTGTAATTAGAAAAAAATAGTACGTACCAGGGTAGGAATTTGGGAAAATACAGAACCGAGGAGAAAACAGAAGT

>7944_7944_6_ATP5C1-ALDH7A1_ATP5C1_chr10_7838118_ENST00000356708_ALDH7A1_chr5_125896816_ENST00000553117_length(amino acids)=215AA_BP=31
MFSRAGVAGLSAWTLQPQWIQVRNMATLKDRRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLVMDRPGNYVEPTIV
TGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATP5C1-ALDH7A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATP5C1-ALDH7A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATP5C1-ALDH7A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC1849508EPILEPSY, PYRIDOXINE-DEPENDENT9CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0005940Bone Diseases1CTD_human
TgeneC0009363Congenital ocular coloboma (disorder)1CTD_human
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC0235874Disease Exacerbation1CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC4554007Uveoretinal Coloboma1CTD_human