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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACO2-ZC3H7B (FusionGDB2 ID:HG50TG23264)

Fusion Gene Summary for ACO2-ZC3H7B

check button Fusion gene summary
Fusion gene informationFusion gene name: ACO2-ZC3H7B
Fusion gene ID: hg50tg23264
HgeneTgene
Gene symbol

ACO2

ZC3H7B

Gene ID

50

23264

Gene nameaconitase 2zinc finger CCCH-type containing 7B
SynonymsACONM|HEL-S-284|ICRD|OCA8|OPA9ROXAN1|RoXaN
Cytomap('ACO2')('ZC3H7B')

22q13.2

22q13.2

Type of geneprotein-codingprotein-coding
Descriptionaconitate hydratase, mitochondrialaconitase 2, mitochondrialcitrate hydro-lyaseepididymis secretory sperm binding protein Li 284mitochondrial aconitasezinc finger CCCH domain-containing protein 7BRotavirus 'X' associated non-structural proteinrotavirus 'X'-associated non-structural proteinrotavirus X protein associated with NSP3ubiquitous tetratricopeptide containing protein RoXaN
Modification date2020031320200313
UniProtAcc

Q99798

Q9UGR2

Ensembl transtripts involved in fusion geneENST00000216254, ENST00000396512, 
ENST00000466237, 
Fusion gene scores* DoF score17 X 8 X 10=136014 X 15 X 6=1260
# samples 2219
** MAII scorelog2(22/1360*10)=-2.62803122261304
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1260*10)=-2.72935241005633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACO2 [Title/Abstract] AND ZC3H7B [Title/Abstract] AND fusion [Title/Abstract]

The landscape and therapeutic relevance of cancer-associated transcript fusions (pmid: 25500544)
Most frequent breakpointACO2(41865186)-ZC3H7B(41751473), # samples:2
ACO2(41865186)-ZC3H7B(41737092), # samples:2
Anticipated loss of major functional domain due to fusion event.ACO2-ZC3H7B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACO2-ZC3H7B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACO2-ZC3H7B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACO2-ZC3H7B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACO2-ZC3H7B seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ACO2-ZC3H7B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ACO2-ZC3H7B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACO2

GO:0006099

tricarboxylic acid cycle

9630632

HgeneACO2

GO:0006101

citrate metabolic process

9630632


check buttonFusion gene breakpoints across ACO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZC3H7B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1X5-01AACO2chr22

41865186

-ZC3H7Bchr22

41751473

+
ChimerDB4BRCATCGA-D8-A1X5-01AACO2chr22

41865186

+ZC3H7Bchr22

41751473

+
ChimerDB4LUADTCGA-75-6211-01AACO2chr22

41865186

+ZC3H7Bchr22

41716659

+
ChimerDB4LUSCTCGA-56-A4BX-01AACO2chr22

41865186

-ZC3H7Bchr22

41737092

+
ChimerDB4LUSCTCGA-56-A4BXACO2chr22

41865186

+ZC3H7Bchr22

41737092

+
ChimerDB4LUSCTCGA-56-A4BXACO2chr22

41865186

+ZC3H7Bchr22

41738533

+
ChimerDB4LUSCTCGA-56-A4BXACO2chr22

41865512

+ZC3H7Bchr22

41737092

+
ChimerDB4OVTCGA-10-0936ACO2chr22

41865186

+ZC3H7Bchr22

41721567

+
ChimerDB4OVTCGA-24-2298-01AACO2chr22

41865186

+ZC3H7Bchr22

41739419

+


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Fusion Gene ORF analysis for ACO2-ZC3H7B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000216254ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41716659

+
5CDS-5UTRENST00000216254ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41716659

+
5CDS-5UTRENST00000396512ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41716659

+
5CDS-5UTRENST00000396512ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41716659

+
Frame-shiftENST00000216254ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41737092

+
Frame-shiftENST00000216254ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41721567

+
Frame-shiftENST00000216254ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41739419

+
Frame-shiftENST00000216254ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41737092

+
Frame-shiftENST00000216254ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41721567

+
Frame-shiftENST00000216254ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41739419

+
Frame-shiftENST00000396512ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41737092

+
Frame-shiftENST00000396512ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41721567

+
Frame-shiftENST00000396512ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41739419

+
Frame-shiftENST00000396512ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41737092

+
Frame-shiftENST00000396512ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41721567

+
Frame-shiftENST00000396512ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41739419

+
In-frameENST00000216254ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41751473

+
In-frameENST00000216254ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41738533

+
In-frameENST00000216254ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41751473

+
In-frameENST00000216254ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41738533

+
In-frameENST00000396512ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41751473

+
In-frameENST00000396512ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41738533

+
In-frameENST00000396512ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41751473

+
In-frameENST00000396512ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41738533

+
intron-3CDSENST00000216254ENST00000351589ACO2chr22

41865512

+ZC3H7Bchr22

41737092

+
intron-3CDSENST00000216254ENST00000352645ACO2chr22

41865512

+ZC3H7Bchr22

41737092

+
intron-3CDSENST00000396512ENST00000351589ACO2chr22

41865512

+ZC3H7Bchr22

41737092

+
intron-3CDSENST00000396512ENST00000352645ACO2chr22

41865512

+ZC3H7Bchr22

41737092

+
intron-3CDSENST00000466237ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41751473

+
intron-3CDSENST00000466237ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41737092

+
intron-3CDSENST00000466237ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41738533

+
intron-3CDSENST00000466237ENST00000351589ACO2chr22

41865512

+ZC3H7Bchr22

41737092

+
intron-3CDSENST00000466237ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41721567

+
intron-3CDSENST00000466237ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41739419

+
intron-3CDSENST00000466237ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41751473

+
intron-3CDSENST00000466237ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41737092

+
intron-3CDSENST00000466237ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41738533

+
intron-3CDSENST00000466237ENST00000352645ACO2chr22

41865512

+ZC3H7Bchr22

41737092

+
intron-3CDSENST00000466237ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41721567

+
intron-3CDSENST00000466237ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41739419

+
intron-5UTRENST00000466237ENST00000351589ACO2chr22

41865186

+ZC3H7Bchr22

41716659

+
intron-5UTRENST00000466237ENST00000352645ACO2chr22

41865186

+ZC3H7Bchr22

41716659

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000216254ACO2chr2241865186+ENST00000352645ZC3H7Bchr2241751473+3676587957316
ENST00000216254ACO2chr2241865186+ENST00000351589ZC3H7Bchr2241751473+3632587957316
ENST00000396512ACO2chr2241865186+ENST00000352645ZC3H7Bchr2241751473+3671532952316
ENST00000396512ACO2chr2241865186+ENST00000351589ZC3H7Bchr2241751473+3627532952316
ENST00000216254ACO2chr2241865186+ENST00000352645ZC3H7Bchr2241738533+45135871794595
ENST00000216254ACO2chr2241865186+ENST00000351589ZC3H7Bchr2241738533+44695871794595
ENST00000396512ACO2chr2241865186+ENST00000352645ZC3H7Bchr2241738533+45085321789595
ENST00000396512ACO2chr2241865186+ENST00000351589ZC3H7Bchr2241738533+44645321789595

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000216254ENST00000352645ACO2chr2241865186+ZC3H7Bchr2241751473+0.0121085340.98789144
ENST00000216254ENST00000351589ACO2chr2241865186+ZC3H7Bchr2241751473+0.0122073460.9877927
ENST00000396512ENST00000352645ACO2chr2241865186+ZC3H7Bchr2241751473+0.0121526480.9878473
ENST00000396512ENST00000351589ACO2chr2241865186+ZC3H7Bchr2241751473+0.0122475060.98775256
ENST00000216254ENST00000352645ACO2chr2241865186+ZC3H7Bchr2241738533+0.0049267640.99507326
ENST00000216254ENST00000351589ACO2chr2241865186+ZC3H7Bchr2241738533+0.0052334890.9947665
ENST00000396512ENST00000352645ACO2chr2241865186+ZC3H7Bchr2241738533+0.0048919430.99510807
ENST00000396512ENST00000351589ACO2chr2241865186+ZC3H7Bchr2241738533+0.0051973570.9948027

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Fusion Genomic Features for ACO2-ZC3H7B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACO2chr2241865186+ZC3H7Bchr2241737091+0.0082982820.99170166
ACO2chr2241865186+ZC3H7Bchr2241721567+9.85E-050.99990153
ACO2chr2241865186+ZC3H7Bchr2241751472+2.24E-050.9999776
ACO2chr2241865186+ZC3H7Bchr2241738532+5.34E-070.9999995
ACO2chr2241865186+ZC3H7Bchr2241716664+1.09E-101
ACO2chr2241865186+ZC3H7Bchr2241739418+7.86E-091
ACO2chr2241865186+ZC3H7Bchr2241737091+0.0082982820.99170166
ACO2chr2241865186+ZC3H7Bchr2241721567+9.85E-050.99990153
ACO2chr2241865186+ZC3H7Bchr2241751472+2.24E-050.9999776
ACO2chr2241865186+ZC3H7Bchr2241738532+5.34E-070.9999995
ACO2chr2241865186+ZC3H7Bchr2241716664+1.09E-101
ACO2chr2241865186+ZC3H7Bchr2241739418+7.86E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACO2-ZC3H7B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:41865186/chr22:41751473)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACO2

Q99798

ZC3H7B

Q9UGR2

FUNCTION: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}.FUNCTION: May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apical loop. {ECO:0000269|PubMed:28431233}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZC3H7Bchr22:41865186chr22:41738533ENST00000351589922484_508399978.0Zinc fingerC3H1-type 1
TgeneZC3H7Bchr22:41865186chr22:41738533ENST00000351589922616_638399978.0Zinc fingerC3H1-type 2
TgeneZC3H7Bchr22:41865186chr22:41738533ENST00000351589922754_782399978.0Zinc fingerC3H1-type 3
TgeneZC3H7Bchr22:41865186chr22:41738533ENST00000351589922842_866399978.0Zinc fingerC2H2-type
TgeneZC3H7Bchr22:41865186chr22:41738533ENST00000351589922886_914399978.0Zinc fingerC3H1-type 4
TgeneZC3H7Bchr22:41865186chr22:41738533ENST000003526451023484_508399978.0Zinc fingerC3H1-type 1
TgeneZC3H7Bchr22:41865186chr22:41738533ENST000003526451023616_638399978.0Zinc fingerC3H1-type 2
TgeneZC3H7Bchr22:41865186chr22:41738533ENST000003526451023754_782399978.0Zinc fingerC3H1-type 3
TgeneZC3H7Bchr22:41865186chr22:41738533ENST000003526451023842_866399978.0Zinc fingerC2H2-type
TgeneZC3H7Bchr22:41865186chr22:41738533ENST000003526451023886_914399978.0Zinc fingerC3H1-type 4
TgeneZC3H7Bchr22:41865186chr22:41751473ENST000003515891522754_782678978.0Zinc fingerC3H1-type 3
TgeneZC3H7Bchr22:41865186chr22:41751473ENST000003515891522842_866678978.0Zinc fingerC2H2-type
TgeneZC3H7Bchr22:41865186chr22:41751473ENST000003515891522886_914678978.0Zinc fingerC3H1-type 4
TgeneZC3H7Bchr22:41865186chr22:41751473ENST000003526451623754_782678978.0Zinc fingerC3H1-type 3
TgeneZC3H7Bchr22:41865186chr22:41751473ENST000003526451623842_866678978.0Zinc fingerC2H2-type
TgeneZC3H7Bchr22:41865186chr22:41751473ENST000003526451623886_914678978.0Zinc fingerC3H1-type 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACO2chr22:41865186chr22:41738533ENST00000216254+118192_19412781.0RegionSubstrate binding
HgeneACO2chr22:41865186chr22:41738533ENST00000216254+118670_67112781.0RegionSubstrate binding
HgeneACO2chr22:41865186chr22:41751473ENST00000216254+118192_19412781.0RegionSubstrate binding
HgeneACO2chr22:41865186chr22:41751473ENST00000216254+118670_67112781.0RegionSubstrate binding
TgeneZC3H7Bchr22:41865186chr22:41738533ENST000003515899221_27399978.0RepeatTPR 1
TgeneZC3H7Bchr22:41865186chr22:41738533ENST0000035158992236_69399978.0RepeatTPR 2
TgeneZC3H7Bchr22:41865186chr22:41738533ENST0000035158992282_115399978.0RepeatTPR 3
TgeneZC3H7Bchr22:41865186chr22:41738533ENST0000035264510231_27399978.0RepeatTPR 1
TgeneZC3H7Bchr22:41865186chr22:41738533ENST00000352645102336_69399978.0RepeatTPR 2
TgeneZC3H7Bchr22:41865186chr22:41738533ENST00000352645102382_115399978.0RepeatTPR 3
TgeneZC3H7Bchr22:41865186chr22:41751473ENST0000035158915221_27678978.0RepeatTPR 1
TgeneZC3H7Bchr22:41865186chr22:41751473ENST00000351589152236_69678978.0RepeatTPR 2
TgeneZC3H7Bchr22:41865186chr22:41751473ENST00000351589152282_115678978.0RepeatTPR 3
TgeneZC3H7Bchr22:41865186chr22:41751473ENST0000035264516231_27678978.0RepeatTPR 1
TgeneZC3H7Bchr22:41865186chr22:41751473ENST00000352645162336_69678978.0RepeatTPR 2
TgeneZC3H7Bchr22:41865186chr22:41751473ENST00000352645162382_115678978.0RepeatTPR 3
TgeneZC3H7Bchr22:41865186chr22:41751473ENST000003515891522484_508678978.0Zinc fingerC3H1-type 1
TgeneZC3H7Bchr22:41865186chr22:41751473ENST000003515891522616_638678978.0Zinc fingerC3H1-type 2
TgeneZC3H7Bchr22:41865186chr22:41751473ENST000003526451623484_508678978.0Zinc fingerC3H1-type 1
TgeneZC3H7Bchr22:41865186chr22:41751473ENST000003526451623616_638678978.0Zinc fingerC3H1-type 2


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Fusion Gene Sequence for ACO2-ZC3H7B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1359_1359_1_ACO2-ZC3H7B_ACO2_chr22_41865186_ENST00000216254_ZC3H7B_chr22_41738533_ENST00000351589_length(transcript)=4469nt_BP=58nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGCCAGAGCCCTGCATGCCCAACACTGCCTTGCT
CATCAAGAACCCCTTGGCTGCCACCCACGAGTTCAAGCAGGCCTGCCAGCTCTGCTACCCCAAGACAGGCCCCCGGGCTGGCGACTACAC
CTACCGTGAGGGCCTTGAGCACAAGTGCAAGCGGGACATCCTGCTCGGCCGGCTCCGGAGCTCGGAGGACCAGACCTGGAAGCGGATCCG
GCCCCGGCCCACTAAGACCAGCTTCGTGGGCTCCTACTACCTGTGCAAAGACATGATTAACAAGCAGGACTGTAAGTACGGGGATAACTG
CACCTTCGCCTACCATCAGGAGGAGATCGACGTGTGGACCGAGGAGCGGAAGGGCACCCTCAACCGCGACCTGCTCTTCGACCCGCTGGG
GGGTGTTAAGCGCGGCAGCCTCACCATCGCCAAGCTCCTGAAGGAGCACCAGGGCATCTTCACCTTCCTCTGCGAGATCTGCTTTGACAG
TAAACCCCGGATCATCAGCAAAGGCACCAAGGACTCTCCGTCTGTCTGCTCCAACCTGGCTGCCAAGCACAGCTTCTACAACAACAAGTG
CCTGGTGCACATCGTCCGCTCCACCTCCCTCAAGTACTCCAAGATCCGCCAGTTCCAGGAGCACTTCCAGTTCGACGTGTGCCGCCATGA
GGTGCGCTACGGCTGCCTGCGGGAGGACAGCTGCCACTTCGCCCACAGCTTCATCGAGCTCAAGGTCTGGCTGCTGCAGCAGTACTCAGG
CATGACCCACGAAGACATCGTTCAGGAGTCTAAGAAGTACTGGCAGCAGATGGAGGCGCATGCGGGGAAGGCCAGCAGCAGCATGGGTGC
TCCGAGGACACATGGGCCCAGCACCTTTGACCTGCAGATGAAGTTTGTATGTGGCCAGTGCTGGAGAAACGGGCAGGTGGTGGAGCCTGA
CAAGGACCTCAAGTACTGTAGTGCCAAGGCCCGGCACTGCTGGACCAAGGAGCGGCGGGTCCTTCTGGTGATGTCCAAGGCCAAGAGGAA
ATGGGTGTCAGTGAGGCCACTGCCATCCATTCGTAACTTCCCACAGCAATACGATCTCTGCATCCATGCACAGAACGGCCGCAAGTGCCA
ATATGTGGGGAACTGCTCCTTCGCACACAGCCCGGAGGAGAGGGACATGTGGACCTTCATGAAGGAGAACAAGATCCTGGACATGCAGCA
GACCTATGACATGTGGCTGAAAAAACACAACCCAGGAAAGCCTGGAGAAGGGACCCCCATCAGTTCTCGGGAAGGGGAGAAGCAGATCCA
GATGCCCACGGACTACGCGGACATCATGATGGGCTACCACTGCTGGCTCTGCGGCAAGAACAGCAACAGCAAGAAGCAGTGGCAGCAGCA
CATCCAGTCCGAGAAGCACAAGGAGAAGGTCTTCACGTCCGACAGTGACGCCAGCGGCTGGGCCTTCCGCTTCCCCATGGGCGAGTTCCG
GCTCTGCGACAGGCTCCAGAAGGGCAAAGCCTGCCCAGATGGGGACAAGTGCCGCTGCGCCCATGGACAGGAGGAGCTCAACGAGTGGCT
GGACCGGCGCGAGGTGCTGAAGCAGAAGTTGGCCAAGGCTCGCAAGGACATGCTGCTGTGCCCACGGGACGACGACTTTGGCAAATACAA
CTTCCTGCTGCAAGAGGACGGGGACCTTGCCGGTGCCACCCCAGAAGCCCCTGCTGCTGCTGCCACCGCCACCACTGGGGAGTAGGGCCA
GGTGTTGGCCGTGGGTGAAGTCCTGGGGTCAGGGGGTGGGGTGGGGCCAGAAGGCCTGATAGAAGGGTCAGGGCAGGCCAGGGGGGTGGG
GGGCCGCCCTCATCAGGCAGCCCCCAGCCCCCTGAGGCCCTGTCCATCTTCTCCCCACCACCGCCCCGGTGTGCGTACCCAGGCGCACGT
GCTGCAGCCCCCGGAGGCCCCGCTGAAACCTGGGCTGCCCTTCCCCCACCCCCACGGCTCTCCTGGTTGAGGAGGGAGGGGCCTGGCTGA
CCCCTCCAGCTTCAGCCTCCAGCTTTAACTTCTGTCTGCTCCTAATGGGGGCCCAAAGCTCAGGGCTGGGGAGCCTGGGGTCCCCACTTG
AATCTCCAGCAGGAGGGTCCTTCTCTCCCTGGCCCGTCCTCCTCCCACCCCCTCCCCCTGGGGGCAAATCAGGACACAACAGAGGGCAGA
GGCCCCATTAGCTTTAAAATGTAGCCCCAGGTTGGAGCTGGGAACACTGTACTGGCCACTTACCCTCTGGGGCCTCAGCTTTCCCTCCGG
AAGGCTGGGAGGAGGTGGGCTAGATGATCTTTGGAGCTTAAGGAGTCCCAGCCCTTTCTCTGATGCCACCACCTGAACCCTGCTCCCTCG
TGGGCCAGTGAAAATAGACTGTAGGTCCTCAGAGCCTTCAGAGATGATCCAGCCCAAACCCCATTTTGCAGAGAGGAAAACTGAGGCCTA
GAAGGGAGGAGTGGTCCACCCACGGTCCCAGCACAAGGCAGAGCTGGGATGAAAACAGGGCTGAAAAGACTCAGGGCCAATTATTGGCTG
AGCCCACGGTCCCCTCAGCAGGGATGCGATGGTCTCTGAATCAGTGTGCAGCTGGGGTCCCAGGCAGCGCTGCCTGGGGGCTGGGGAGGG
GAGGCCCAGAGGAGGGCTGGCCATGTGAGCACCCCATGAAGGGACCGCCCCCTCCCAAGGATGGTCCCTTTGGGTGCAGCAGCAGAGGTC
ACCTCCTGACATGCGCTCTGGGAAAGGTGGCAGAGGGCAGGACACCATGAGCTCAGGATCTGTGTGAGGTGTGGGAGGTGGGAAGGGTGA
GGGTCTGGGGGAATGCGGAGAAAAGGGAGGCTTGACCCCGGGCACCATGGGCCACTCCAGGATGGGACACGGCCCCTCTTTCTTGGGGAC
CCAGTATGTCCTCTCCTCTAGACCCAGACATACAGTTATAACCGTCTGTCCTAGCCCCTCCCTAATCCCTGGCCCTCCCAGCTGTCTGGG
ACTTCAGTGGACCCCCAGCCCCTGCCCCCACTCACCAAGGCCTCGCTCGTCCCTCTCGTCTGACATGTCTGTGTGCACCCCCCTCCTCTC
CACCCTACCTTCCATCAACCAGGGCAGATCCACCGTGCCCTGGTTCCCCAGACATTCCAGAATGCCCCACATCATTGGCACAGGAGTGGG
GCAGCCCCGGAAGGAACCAGGGATTAGGCTGTAGGGGGGTGAGAAGGAGAGAAGGGACCACCCCATTCTTCTCAAGCAAGGATTGCCAGC
GCGCGCTGACACAGTGATGGGCTGCCCAGGGCTGGAGGGGACGCTGTTCCTCCCGCCGCCACTGCCCAACCTTTCCTGATAATCGTGGCA
TGCGCCCTTTCCTCTTCCCTGCCCCACCCCCTGGCCGCAGCAGGCCAGCACTGCAGAGTTTGGGTGCTGGTGGTGTGGCTGTAGGGGAGG
GGAGACCACACCCAAGGTGGGGGCTGTGGCCATGTGTGGCCGTGATGTCGATGATACTCGTTTTCCCTGATCCGTGGTGTTGCAGTCCGT
TGTCACCAGCCTTGTTTCTAGTGTGTATATATGTCGCCCCCGTGATGCATATATACACAGGTATTAAATATATCGCTCTATATAATATTA
TATATGTGTGTGGTATCCAAGGAATCACTTTTATGAGGGCTAAAGATAAAGAATTTGGCCAGAAAATGCAGCCATCCTTGTGTGATTAGG
AGGGTTTCAGGGGCCACTGGACTATTTGCAAGGTGACAGGGACTGGAGCCATGGCTCAGAGGTGATTCGGGCAGCCAGGGACAGGAGCCA
CCCTCCCCAGGCCCAACTCTGCTAGCTTCCCAGACCACCCCCATCGAGTGCGGAGAGAGTGGGAGTGCTCAGGGAAAGAAGGTGATTTGT
ATTTGTCTCCCCGCTGAAAAGAACAGGATTCAAGTCCAGAGTTTTCATCTTCAGCCTGTGATCTGTCCAGGGACCCTTGGGATCTGGGGC
TTCCTGGCCTGGCCAGAGCTGGAGCCCCCACAGGGTAAGGAAGAGAGAGTGGGAGGCAGAGTGTGATGGGGAGGAGGGACAGGAAGACCC
TTTTAATGATGAGGGTAACTATTTCAGTTGTGAGCCTTCTAGGGCCCCAGGCTGGGAGGCTCAGAGGACTGAATCTGGGACCTGTGTTCC
CCCCGGCAGGCAGGGACAAGATGGCATGGCAAGCATGGGGGCGGGGTGGGTGGGGAGGGATGCTGCATTTCTCAGCTGGGCAGTAATCAA
TTTAATGGTCCTTTAAAATGTCTGTGTATTAAAAATTTAAGAATACCACACTTTAATATTAAATATTCATAAGGTCTAGTATCTTGATAA

>1359_1359_1_ACO2-ZC3H7B_ACO2_chr22_41865186_ENST00000216254_ZC3H7B_chr22_41738533_ENST00000351589_length(amino acids)=595AA_BP=16
MSVHKMAPYSLLVTRLQPEPCMPNTALLIKNPLAATHEFKQACQLCYPKTGPRAGDYTYREGLEHKCKRDILLGRLRSSEDQTWKRIRPR
PTKTSFVGSYYLCKDMINKQDCKYGDNCTFAYHQEEIDVWTEERKGTLNRDLLFDPLGGVKRGSLTIAKLLKEHQGIFTFLCEICFDSKP
RIISKGTKDSPSVCSNLAAKHSFYNNKCLVHIVRSTSLKYSKIRQFQEHFQFDVCRHEVRYGCLREDSCHFAHSFIELKVWLLQQYSGMT
HEDIVQESKKYWQQMEAHAGKASSSMGAPRTHGPSTFDLQMKFVCGQCWRNGQVVEPDKDLKYCSAKARHCWTKERRVLLVMSKAKRKWV
SVRPLPSIRNFPQQYDLCIHAQNGRKCQYVGNCSFAHSPEERDMWTFMKENKILDMQQTYDMWLKKHNPGKPGEGTPISSREGEKQIQMP
TDYADIMMGYHCWLCGKNSNSKKQWQQHIQSEKHKEKVFTSDSDASGWAFRFPMGEFRLCDRLQKGKACPDGDKCRCAHGQEELNEWLDR

--------------------------------------------------------------
>1359_1359_2_ACO2-ZC3H7B_ACO2_chr22_41865186_ENST00000216254_ZC3H7B_chr22_41738533_ENST00000352645_length(transcript)=4513nt_BP=58nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGCCAGAGCCCTGCATGCCCAACACTGCCTTGCT
CATCAAGAACCCCTTGGCTGCCACCCACGAGTTCAAGCAGGCCTGCCAGCTCTGCTACCCCAAGACAGGCCCCCGGGCTGGCGACTACAC
CTACCGTGAGGGCCTTGAGCACAAGTGCAAGCGGGACATCCTGCTCGGCCGGCTCCGGAGCTCGGAGGACCAGACCTGGAAGCGGATCCG
GCCCCGGCCCACTAAGACCAGCTTCGTGGGCTCCTACTACCTGTGCAAAGACATGATTAACAAGCAGGACTGTAAGTACGGGGATAACTG
CACCTTCGCCTACCATCAGGAGGAGATCGACGTGTGGACCGAGGAGCGGAAGGGCACCCTCAACCGCGACCTGCTCTTCGACCCGCTGGG
GGGTGTTAAGCGCGGCAGCCTCACCATCGCCAAGCTCCTGAAGGAGCACCAGGGCATCTTCACCTTCCTCTGCGAGATCTGCTTTGACAG
TAAACCCCGGATCATCAGCAAAGGCACCAAGGACTCTCCGTCTGTCTGCTCCAACCTGGCTGCCAAGCACAGCTTCTACAACAACAAGTG
CCTGGTGCACATCGTCCGCTCCACCTCCCTCAAGTACTCCAAGATCCGCCAGTTCCAGGAGCACTTCCAGTTCGACGTGTGCCGCCATGA
GGTGCGCTACGGCTGCCTGCGGGAGGACAGCTGCCACTTCGCCCACAGCTTCATCGAGCTCAAGGTCTGGCTGCTGCAGCAGTACTCAGG
CATGACCCACGAAGACATCGTTCAGGAGTCTAAGAAGTACTGGCAGCAGATGGAGGCGCATGCGGGGAAGGCCAGCAGCAGCATGGGTGC
TCCGAGGACACATGGGCCCAGCACCTTTGACCTGCAGATGAAGTTTGTATGTGGCCAGTGCTGGAGAAACGGGCAGGTGGTGGAGCCTGA
CAAGGACCTCAAGTACTGTAGTGCCAAGGCCCGGCACTGCTGGACCAAGGAGCGGCGGGTCCTTCTGGTGATGTCCAAGGCCAAGAGGAA
ATGGGTGTCAGTGAGGCCACTGCCATCCATTCGTAACTTCCCACAGCAATACGATCTCTGCATCCATGCACAGAACGGCCGCAAGTGCCA
ATATGTGGGGAACTGCTCCTTCGCACACAGCCCGGAGGAGAGGGACATGTGGACCTTCATGAAGGAGAACAAGATCCTGGACATGCAGCA
GACCTATGACATGTGGCTGAAAAAACACAACCCAGGAAAGCCTGGAGAAGGGACCCCCATCAGTTCTCGGGAAGGGGAGAAGCAGATCCA
GATGCCCACGGACTACGCGGACATCATGATGGGCTACCACTGCTGGCTCTGCGGCAAGAACAGCAACAGCAAGAAGCAGTGGCAGCAGCA
CATCCAGTCCGAGAAGCACAAGGAGAAGGTCTTCACGTCCGACAGTGACGCCAGCGGCTGGGCCTTCCGCTTCCCCATGGGCGAGTTCCG
GCTCTGCGACAGGCTCCAGAAGGGCAAAGCCTGCCCAGATGGGGACAAGTGCCGCTGCGCCCATGGACAGGAGGAGCTCAACGAGTGGCT
GGACCGGCGCGAGGTGCTGAAGCAGAAGTTGGCCAAGGCTCGCAAGGACATGCTGCTGTGCCCACGGGACGACGACTTTGGCAAATACAA
CTTCCTGCTGCAAGAGGACGGGGACCTTGCCGGTGCCACCCCAGAAGCCCCTGCTGCTGCTGCCACCGCCACCACTGGGGAGTAGGGCCA
GGTGTTGGCCGTGGGTGAAGTCCTGGGGTCAGGGGGTGGGGTGGGGCCAGAAGGCCTGATAGAAGGGTCAGGGCAGGCCAGGGGGGTGGG
GGGCCGCCCTCATCAGGCAGCCCCCAGCCCCCTGAGGCCCTGTCCATCTTCTCCCCACCACCGCCCCGGTGTGCGTACCCAGGCGCACGT
GCTGCAGCCCCCGGAGGCCCCGCTGAAACCTGGGCTGCCCTTCCCCCACCCCCACGGCTCTCCTGGTTGAGGAGGGAGGGGCCTGGCTGA
CCCCTCCAGCTTCAGCCTCCAGCTTTAACTTCTGTCTGCTCCTAATGGGGGCCCAAAGCTCAGGGCTGGGGAGCCTGGGGTCCCCACTTG
AATCTCCAGCAGGAGGGTCCTTCTCTCCCTGGCCCGTCCTCCTCCCACCCCCTCCCCCTGGGGGCAAATCAGGACACAACAGAGGGCAGA
GGCCCCATTAGCTTTAAAATGTAGCCCCAGGTTGGAGCTGGGAACACTGTACTGGCCACTTACCCTCTGGGGCCTCAGCTTTCCCTCCGG
AAGGCTGGGAGGAGGTGGGCTAGATGATCTTTGGAGCTTAAGGAGTCCCAGCCCTTTCTCTGATGCCACCACCTGAACCCTGCTCCCTCG
TGGGCCAGTGAAAATAGACTGTAGGTCCTCAGAGCCTTCAGAGATGATCCAGCCCAAACCCCATTTTGCAGAGAGGAAAACTGAGGCCTA
GAAGGGAGGAGTGGTCCACCCACGGTCCCAGCACAAGGCAGAGCTGGGATGAAAACAGGGCTGAAAAGACTCAGGGCCAATTATTGGCTG
AGCCCACGGTCCCCTCAGCAGGGATGCGATGGTCTCTGAATCAGTGTGCAGCTGGGGTCCCAGGCAGCGCTGCCTGGGGGCTGGGGAGGG
GAGGCCCAGAGGAGGGCTGGCCATGTGAGCACCCCATGAAGGGACCGCCCCCTCCCAAGGATGGTCCCTTTGGGTGCAGCAGCAGAGGTC
ACCTCCTGACATGCGCTCTGGGAAAGGTGGCAGAGGGCAGGACACCATGAGCTCAGGATCTGTGTGAGGTGTGGGAGGTGGGAAGGGTGA
GGGTCTGGGGGAATGCGGAGAAAAGGGAGGCTTGACCCCGGGCACCATGGGCCACTCCAGGATGGGACACGGCCCCTCTTTCTTGGGGAC
CCAGTATGTCCTCTCCTCTAGACCCAGACATACAGTTATAACCGTCTGTCCTAGCCCCTCCCTAATCCCTGGCCCTCCCAGCTGTCTGGG
ACTTCAGTGGACCCCCAGCCCCTGCCCCCACTCACCAAGGCCTCGCTCGTCCCTCTCGTCTGACATGTCTGTGTGCACCCCCCTCCTCTC
CACCCTACCTTCCATCAACCAGGGCAGATCCACCGTGCCCTGGTTCCCCAGACATTCCAGAATGCCCCACATCATTGGCACAGGAGTGGG
GCAGCCCCGGAAGGAACCAGGGATTAGGCTGTAGGGGGGTGAGAAGGAGAGAAGGGACCACCCCATTCTTCTCAAGCAAGGATTGCCAGC
GCGCGCTGACACAGTGATGGGCTGCCCAGGGCTGGAGGGGACGCTGTTCCTCCCGCCGCCACTGCCCAACCTTTCCTGATAATCGTGGCA
TGCGCCCTTTCCTCTTCCCTGCCCCACCCCCTGGCCGCAGCAGGCCAGCACTGCAGAGTTTGGGTGCTGGTGGTGTGGCTGTAGGGGAGG
GGAGACCACACCCAAGGTGGGGGCTGTGGCCATGTGTGGCCGTGATGTCGATGATACTCGTTTTCCCTGATCCGTGGTGTTGCAGTCCGT
TGTCACCAGCCTTGTTTCTAGTGTGTATATATGTCGCCCCCGTGATGCATATATACACAGGTATTAAATATATCGCTCTATATAATATTA
TATATGTGTGTGGTATCCAAGGAATCACTTTTATGAGGGCTAAAGATAAAGAATTTGGCCAGAAAATGCAGCCATCCTTGTGTGATTAGG
AGGGTTTCAGGGGCCACTGGACTATTTGCAAGGTGACAGGGACTGGAGCCATGGCTCAGAGGTGATTCGGGCAGCCAGGGACAGGAGCCA
CCCTCCCCAGGCCCAACTCTGCTAGCTTCCCAGACCACCCCCATCGAGTGCGGAGAGAGTGGGAGTGCTCAGGGAAAGAAGGTGATTTGT
ATTTGTCTCCCCGCTGAAAAGAACAGGATTCAAGTCCAGAGTTTTCATCTTCAGCCTGTGATCTGTCCAGGGACCCTTGGGATCTGGGGC
TTCCTGGCCTGGCCAGAGCTGGAGCCCCCACAGGGTAAGGAAGAGAGAGTGGGAGGCAGAGTGTGATGGGGAGGAGGGACAGGAAGACCC
TTTTAATGATGAGGGTAACTATTTCAGTTGTGAGCCTTCTAGGGCCCCAGGCTGGGAGGCTCAGAGGACTGAATCTGGGACCTGTGTTCC
CCCCGGCAGGCAGGGACAAGATGGCATGGCAAGCATGGGGGCGGGGTGGGTGGGGAGGGATGCTGCATTTCTCAGCTGGGCAGTAATCAA
TTTAATGGTCCTTTAAAATGTCTGTGTATTAAAAATTTAAGAATACCACACTTTAATATTAAATATTCATAAGGTCTAGTATCTTGATAA
TAATGTAGATGTTTTAATAACAATTTTTGTCCTTCTTAAAATAAAATGAAAGAAACTTGCTTCCCTTAGCCTTTGTTCTAGAAAATAAAC

>1359_1359_2_ACO2-ZC3H7B_ACO2_chr22_41865186_ENST00000216254_ZC3H7B_chr22_41738533_ENST00000352645_length(amino acids)=595AA_BP=16
MSVHKMAPYSLLVTRLQPEPCMPNTALLIKNPLAATHEFKQACQLCYPKTGPRAGDYTYREGLEHKCKRDILLGRLRSSEDQTWKRIRPR
PTKTSFVGSYYLCKDMINKQDCKYGDNCTFAYHQEEIDVWTEERKGTLNRDLLFDPLGGVKRGSLTIAKLLKEHQGIFTFLCEICFDSKP
RIISKGTKDSPSVCSNLAAKHSFYNNKCLVHIVRSTSLKYSKIRQFQEHFQFDVCRHEVRYGCLREDSCHFAHSFIELKVWLLQQYSGMT
HEDIVQESKKYWQQMEAHAGKASSSMGAPRTHGPSTFDLQMKFVCGQCWRNGQVVEPDKDLKYCSAKARHCWTKERRVLLVMSKAKRKWV
SVRPLPSIRNFPQQYDLCIHAQNGRKCQYVGNCSFAHSPEERDMWTFMKENKILDMQQTYDMWLKKHNPGKPGEGTPISSREGEKQIQMP
TDYADIMMGYHCWLCGKNSNSKKQWQQHIQSEKHKEKVFTSDSDASGWAFRFPMGEFRLCDRLQKGKACPDGDKCRCAHGQEELNEWLDR

--------------------------------------------------------------
>1359_1359_3_ACO2-ZC3H7B_ACO2_chr22_41865186_ENST00000216254_ZC3H7B_chr22_41751473_ENST00000351589_length(transcript)=3632nt_BP=58nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGGGTGCTCCGAGGACACATGGGCCCAGCACCTT
TGACCTGCAGATGAAGTTTGTATGTGGCCAGTGCTGGAGAAACGGGCAGGTGGTGGAGCCTGACAAGGACCTCAAGTACTGTAGTGCCAA
GGCCCGGCACTGCTGGACCAAGGAGCGGCGGGTCCTTCTGGTGATGTCCAAGGCCAAGAGGAAATGGGTGTCAGTGAGGCCACTGCCATC
CATTCGTAACTTCCCACAGCAATACGATCTCTGCATCCATGCACAGAACGGCCGCAAGTGCCAATATGTGGGGAACTGCTCCTTCGCACA
CAGCCCGGAGGAGAGGGACATGTGGACCTTCATGAAGGAGAACAAGATCCTGGACATGCAGCAGACCTATGACATGTGGCTGAAAAAACA
CAACCCAGGAAAGCCTGGAGAAGGGACCCCCATCAGTTCTCGGGAAGGGGAGAAGCAGATCCAGATGCCCACGGACTACGCGGACATCAT
GATGGGCTACCACTGCTGGCTCTGCGGCAAGAACAGCAACAGCAAGAAGCAGTGGCAGCAGCACATCCAGTCCGAGAAGCACAAGGAGAA
GGTCTTCACGTCCGACAGTGACGCCAGCGGCTGGGCCTTCCGCTTCCCCATGGGCGAGTTCCGGCTCTGCGACAGGCTCCAGAAGGGCAA
AGCCTGCCCAGATGGGGACAAGTGCCGCTGCGCCCATGGACAGGAGGAGCTCAACGAGTGGCTGGACCGGCGCGAGGTGCTGAAGCAGAA
GTTGGCCAAGGCTCGCAAGGACATGCTGCTGTGCCCACGGGACGACGACTTTGGCAAATACAACTTCCTGCTGCAAGAGGACGGGGACCT
TGCCGGTGCCACCCCAGAAGCCCCTGCTGCTGCTGCCACCGCCACCACTGGGGAGTAGGGCCAGGTGTTGGCCGTGGGTGAAGTCCTGGG
GTCAGGGGGTGGGGTGGGGCCAGAAGGCCTGATAGAAGGGTCAGGGCAGGCCAGGGGGGTGGGGGGCCGCCCTCATCAGGCAGCCCCCAG
CCCCCTGAGGCCCTGTCCATCTTCTCCCCACCACCGCCCCGGTGTGCGTACCCAGGCGCACGTGCTGCAGCCCCCGGAGGCCCCGCTGAA
ACCTGGGCTGCCCTTCCCCCACCCCCACGGCTCTCCTGGTTGAGGAGGGAGGGGCCTGGCTGACCCCTCCAGCTTCAGCCTCCAGCTTTA
ACTTCTGTCTGCTCCTAATGGGGGCCCAAAGCTCAGGGCTGGGGAGCCTGGGGTCCCCACTTGAATCTCCAGCAGGAGGGTCCTTCTCTC
CCTGGCCCGTCCTCCTCCCACCCCCTCCCCCTGGGGGCAAATCAGGACACAACAGAGGGCAGAGGCCCCATTAGCTTTAAAATGTAGCCC
CAGGTTGGAGCTGGGAACACTGTACTGGCCACTTACCCTCTGGGGCCTCAGCTTTCCCTCCGGAAGGCTGGGAGGAGGTGGGCTAGATGA
TCTTTGGAGCTTAAGGAGTCCCAGCCCTTTCTCTGATGCCACCACCTGAACCCTGCTCCCTCGTGGGCCAGTGAAAATAGACTGTAGGTC
CTCAGAGCCTTCAGAGATGATCCAGCCCAAACCCCATTTTGCAGAGAGGAAAACTGAGGCCTAGAAGGGAGGAGTGGTCCACCCACGGTC
CCAGCACAAGGCAGAGCTGGGATGAAAACAGGGCTGAAAAGACTCAGGGCCAATTATTGGCTGAGCCCACGGTCCCCTCAGCAGGGATGC
GATGGTCTCTGAATCAGTGTGCAGCTGGGGTCCCAGGCAGCGCTGCCTGGGGGCTGGGGAGGGGAGGCCCAGAGGAGGGCTGGCCATGTG
AGCACCCCATGAAGGGACCGCCCCCTCCCAAGGATGGTCCCTTTGGGTGCAGCAGCAGAGGTCACCTCCTGACATGCGCTCTGGGAAAGG
TGGCAGAGGGCAGGACACCATGAGCTCAGGATCTGTGTGAGGTGTGGGAGGTGGGAAGGGTGAGGGTCTGGGGGAATGCGGAGAAAAGGG
AGGCTTGACCCCGGGCACCATGGGCCACTCCAGGATGGGACACGGCCCCTCTTTCTTGGGGACCCAGTATGTCCTCTCCTCTAGACCCAG
ACATACAGTTATAACCGTCTGTCCTAGCCCCTCCCTAATCCCTGGCCCTCCCAGCTGTCTGGGACTTCAGTGGACCCCCAGCCCCTGCCC
CCACTCACCAAGGCCTCGCTCGTCCCTCTCGTCTGACATGTCTGTGTGCACCCCCCTCCTCTCCACCCTACCTTCCATCAACCAGGGCAG
ATCCACCGTGCCCTGGTTCCCCAGACATTCCAGAATGCCCCACATCATTGGCACAGGAGTGGGGCAGCCCCGGAAGGAACCAGGGATTAG
GCTGTAGGGGGGTGAGAAGGAGAGAAGGGACCACCCCATTCTTCTCAAGCAAGGATTGCCAGCGCGCGCTGACACAGTGATGGGCTGCCC
AGGGCTGGAGGGGACGCTGTTCCTCCCGCCGCCACTGCCCAACCTTTCCTGATAATCGTGGCATGCGCCCTTTCCTCTTCCCTGCCCCAC
CCCCTGGCCGCAGCAGGCCAGCACTGCAGAGTTTGGGTGCTGGTGGTGTGGCTGTAGGGGAGGGGAGACCACACCCAAGGTGGGGGCTGT
GGCCATGTGTGGCCGTGATGTCGATGATACTCGTTTTCCCTGATCCGTGGTGTTGCAGTCCGTTGTCACCAGCCTTGTTTCTAGTGTGTA
TATATGTCGCCCCCGTGATGCATATATACACAGGTATTAAATATATCGCTCTATATAATATTATATATGTGTGTGGTATCCAAGGAATCA
CTTTTATGAGGGCTAAAGATAAAGAATTTGGCCAGAAAATGCAGCCATCCTTGTGTGATTAGGAGGGTTTCAGGGGCCACTGGACTATTT
GCAAGGTGACAGGGACTGGAGCCATGGCTCAGAGGTGATTCGGGCAGCCAGGGACAGGAGCCACCCTCCCCAGGCCCAACTCTGCTAGCT
TCCCAGACCACCCCCATCGAGTGCGGAGAGAGTGGGAGTGCTCAGGGAAAGAAGGTGATTTGTATTTGTCTCCCCGCTGAAAAGAACAGG
ATTCAAGTCCAGAGTTTTCATCTTCAGCCTGTGATCTGTCCAGGGACCCTTGGGATCTGGGGCTTCCTGGCCTGGCCAGAGCTGGAGCCC
CCACAGGGTAAGGAAGAGAGAGTGGGAGGCAGAGTGTGATGGGGAGGAGGGACAGGAAGACCCTTTTAATGATGAGGGTAACTATTTCAG
TTGTGAGCCTTCTAGGGCCCCAGGCTGGGAGGCTCAGAGGACTGAATCTGGGACCTGTGTTCCCCCCGGCAGGCAGGGACAAGATGGCAT
GGCAAGCATGGGGGCGGGGTGGGTGGGGAGGGATGCTGCATTTCTCAGCTGGGCAGTAATCAATTTAATGGTCCTTTAAAATGTCTGTGT
ATTAAAAATTTAAGAATACCACACTTTAATATTAAATATTCATAAGGTCTAGTATCTTGATAATAATGTAGATGTTTTAATAACAATTTT

>1359_1359_3_ACO2-ZC3H7B_ACO2_chr22_41865186_ENST00000216254_ZC3H7B_chr22_41751473_ENST00000351589_length(amino acids)=316AA_BP=16
MSVHKMAPYSLLVTRLQGAPRTHGPSTFDLQMKFVCGQCWRNGQVVEPDKDLKYCSAKARHCWTKERRVLLVMSKAKRKWVSVRPLPSIR
NFPQQYDLCIHAQNGRKCQYVGNCSFAHSPEERDMWTFMKENKILDMQQTYDMWLKKHNPGKPGEGTPISSREGEKQIQMPTDYADIMMG
YHCWLCGKNSNSKKQWQQHIQSEKHKEKVFTSDSDASGWAFRFPMGEFRLCDRLQKGKACPDGDKCRCAHGQEELNEWLDRREVLKQKLA

--------------------------------------------------------------
>1359_1359_4_ACO2-ZC3H7B_ACO2_chr22_41865186_ENST00000216254_ZC3H7B_chr22_41751473_ENST00000352645_length(transcript)=3676nt_BP=58nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGGGTGCTCCGAGGACACATGGGCCCAGCACCTT
TGACCTGCAGATGAAGTTTGTATGTGGCCAGTGCTGGAGAAACGGGCAGGTGGTGGAGCCTGACAAGGACCTCAAGTACTGTAGTGCCAA
GGCCCGGCACTGCTGGACCAAGGAGCGGCGGGTCCTTCTGGTGATGTCCAAGGCCAAGAGGAAATGGGTGTCAGTGAGGCCACTGCCATC
CATTCGTAACTTCCCACAGCAATACGATCTCTGCATCCATGCACAGAACGGCCGCAAGTGCCAATATGTGGGGAACTGCTCCTTCGCACA
CAGCCCGGAGGAGAGGGACATGTGGACCTTCATGAAGGAGAACAAGATCCTGGACATGCAGCAGACCTATGACATGTGGCTGAAAAAACA
CAACCCAGGAAAGCCTGGAGAAGGGACCCCCATCAGTTCTCGGGAAGGGGAGAAGCAGATCCAGATGCCCACGGACTACGCGGACATCAT
GATGGGCTACCACTGCTGGCTCTGCGGCAAGAACAGCAACAGCAAGAAGCAGTGGCAGCAGCACATCCAGTCCGAGAAGCACAAGGAGAA
GGTCTTCACGTCCGACAGTGACGCCAGCGGCTGGGCCTTCCGCTTCCCCATGGGCGAGTTCCGGCTCTGCGACAGGCTCCAGAAGGGCAA
AGCCTGCCCAGATGGGGACAAGTGCCGCTGCGCCCATGGACAGGAGGAGCTCAACGAGTGGCTGGACCGGCGCGAGGTGCTGAAGCAGAA
GTTGGCCAAGGCTCGCAAGGACATGCTGCTGTGCCCACGGGACGACGACTTTGGCAAATACAACTTCCTGCTGCAAGAGGACGGGGACCT
TGCCGGTGCCACCCCAGAAGCCCCTGCTGCTGCTGCCACCGCCACCACTGGGGAGTAGGGCCAGGTGTTGGCCGTGGGTGAAGTCCTGGG
GTCAGGGGGTGGGGTGGGGCCAGAAGGCCTGATAGAAGGGTCAGGGCAGGCCAGGGGGGTGGGGGGCCGCCCTCATCAGGCAGCCCCCAG
CCCCCTGAGGCCCTGTCCATCTTCTCCCCACCACCGCCCCGGTGTGCGTACCCAGGCGCACGTGCTGCAGCCCCCGGAGGCCCCGCTGAA
ACCTGGGCTGCCCTTCCCCCACCCCCACGGCTCTCCTGGTTGAGGAGGGAGGGGCCTGGCTGACCCCTCCAGCTTCAGCCTCCAGCTTTA
ACTTCTGTCTGCTCCTAATGGGGGCCCAAAGCTCAGGGCTGGGGAGCCTGGGGTCCCCACTTGAATCTCCAGCAGGAGGGTCCTTCTCTC
CCTGGCCCGTCCTCCTCCCACCCCCTCCCCCTGGGGGCAAATCAGGACACAACAGAGGGCAGAGGCCCCATTAGCTTTAAAATGTAGCCC
CAGGTTGGAGCTGGGAACACTGTACTGGCCACTTACCCTCTGGGGCCTCAGCTTTCCCTCCGGAAGGCTGGGAGGAGGTGGGCTAGATGA
TCTTTGGAGCTTAAGGAGTCCCAGCCCTTTCTCTGATGCCACCACCTGAACCCTGCTCCCTCGTGGGCCAGTGAAAATAGACTGTAGGTC
CTCAGAGCCTTCAGAGATGATCCAGCCCAAACCCCATTTTGCAGAGAGGAAAACTGAGGCCTAGAAGGGAGGAGTGGTCCACCCACGGTC
CCAGCACAAGGCAGAGCTGGGATGAAAACAGGGCTGAAAAGACTCAGGGCCAATTATTGGCTGAGCCCACGGTCCCCTCAGCAGGGATGC
GATGGTCTCTGAATCAGTGTGCAGCTGGGGTCCCAGGCAGCGCTGCCTGGGGGCTGGGGAGGGGAGGCCCAGAGGAGGGCTGGCCATGTG
AGCACCCCATGAAGGGACCGCCCCCTCCCAAGGATGGTCCCTTTGGGTGCAGCAGCAGAGGTCACCTCCTGACATGCGCTCTGGGAAAGG
TGGCAGAGGGCAGGACACCATGAGCTCAGGATCTGTGTGAGGTGTGGGAGGTGGGAAGGGTGAGGGTCTGGGGGAATGCGGAGAAAAGGG
AGGCTTGACCCCGGGCACCATGGGCCACTCCAGGATGGGACACGGCCCCTCTTTCTTGGGGACCCAGTATGTCCTCTCCTCTAGACCCAG
ACATACAGTTATAACCGTCTGTCCTAGCCCCTCCCTAATCCCTGGCCCTCCCAGCTGTCTGGGACTTCAGTGGACCCCCAGCCCCTGCCC
CCACTCACCAAGGCCTCGCTCGTCCCTCTCGTCTGACATGTCTGTGTGCACCCCCCTCCTCTCCACCCTACCTTCCATCAACCAGGGCAG
ATCCACCGTGCCCTGGTTCCCCAGACATTCCAGAATGCCCCACATCATTGGCACAGGAGTGGGGCAGCCCCGGAAGGAACCAGGGATTAG
GCTGTAGGGGGGTGAGAAGGAGAGAAGGGACCACCCCATTCTTCTCAAGCAAGGATTGCCAGCGCGCGCTGACACAGTGATGGGCTGCCC
AGGGCTGGAGGGGACGCTGTTCCTCCCGCCGCCACTGCCCAACCTTTCCTGATAATCGTGGCATGCGCCCTTTCCTCTTCCCTGCCCCAC
CCCCTGGCCGCAGCAGGCCAGCACTGCAGAGTTTGGGTGCTGGTGGTGTGGCTGTAGGGGAGGGGAGACCACACCCAAGGTGGGGGCTGT
GGCCATGTGTGGCCGTGATGTCGATGATACTCGTTTTCCCTGATCCGTGGTGTTGCAGTCCGTTGTCACCAGCCTTGTTTCTAGTGTGTA
TATATGTCGCCCCCGTGATGCATATATACACAGGTATTAAATATATCGCTCTATATAATATTATATATGTGTGTGGTATCCAAGGAATCA
CTTTTATGAGGGCTAAAGATAAAGAATTTGGCCAGAAAATGCAGCCATCCTTGTGTGATTAGGAGGGTTTCAGGGGCCACTGGACTATTT
GCAAGGTGACAGGGACTGGAGCCATGGCTCAGAGGTGATTCGGGCAGCCAGGGACAGGAGCCACCCTCCCCAGGCCCAACTCTGCTAGCT
TCCCAGACCACCCCCATCGAGTGCGGAGAGAGTGGGAGTGCTCAGGGAAAGAAGGTGATTTGTATTTGTCTCCCCGCTGAAAAGAACAGG
ATTCAAGTCCAGAGTTTTCATCTTCAGCCTGTGATCTGTCCAGGGACCCTTGGGATCTGGGGCTTCCTGGCCTGGCCAGAGCTGGAGCCC
CCACAGGGTAAGGAAGAGAGAGTGGGAGGCAGAGTGTGATGGGGAGGAGGGACAGGAAGACCCTTTTAATGATGAGGGTAACTATTTCAG
TTGTGAGCCTTCTAGGGCCCCAGGCTGGGAGGCTCAGAGGACTGAATCTGGGACCTGTGTTCCCCCCGGCAGGCAGGGACAAGATGGCAT
GGCAAGCATGGGGGCGGGGTGGGTGGGGAGGGATGCTGCATTTCTCAGCTGGGCAGTAATCAATTTAATGGTCCTTTAAAATGTCTGTGT
ATTAAAAATTTAAGAATACCACACTTTAATATTAAATATTCATAAGGTCTAGTATCTTGATAATAATGTAGATGTTTTAATAACAATTTT

>1359_1359_4_ACO2-ZC3H7B_ACO2_chr22_41865186_ENST00000216254_ZC3H7B_chr22_41751473_ENST00000352645_length(amino acids)=316AA_BP=16
MSVHKMAPYSLLVTRLQGAPRTHGPSTFDLQMKFVCGQCWRNGQVVEPDKDLKYCSAKARHCWTKERRVLLVMSKAKRKWVSVRPLPSIR
NFPQQYDLCIHAQNGRKCQYVGNCSFAHSPEERDMWTFMKENKILDMQQTYDMWLKKHNPGKPGEGTPISSREGEKQIQMPTDYADIMMG
YHCWLCGKNSNSKKQWQQHIQSEKHKEKVFTSDSDASGWAFRFPMGEFRLCDRLQKGKACPDGDKCRCAHGQEELNEWLDRREVLKQKLA

--------------------------------------------------------------
>1359_1359_5_ACO2-ZC3H7B_ACO2_chr22_41865186_ENST00000396512_ZC3H7B_chr22_41738533_ENST00000351589_length(transcript)=4464nt_BP=53nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGCCAGAGCCCTGCATGCCCAACACTGCCTTGCTCATCA
AGAACCCCTTGGCTGCCACCCACGAGTTCAAGCAGGCCTGCCAGCTCTGCTACCCCAAGACAGGCCCCCGGGCTGGCGACTACACCTACC
GTGAGGGCCTTGAGCACAAGTGCAAGCGGGACATCCTGCTCGGCCGGCTCCGGAGCTCGGAGGACCAGACCTGGAAGCGGATCCGGCCCC
GGCCCACTAAGACCAGCTTCGTGGGCTCCTACTACCTGTGCAAAGACATGATTAACAAGCAGGACTGTAAGTACGGGGATAACTGCACCT
TCGCCTACCATCAGGAGGAGATCGACGTGTGGACCGAGGAGCGGAAGGGCACCCTCAACCGCGACCTGCTCTTCGACCCGCTGGGGGGTG
TTAAGCGCGGCAGCCTCACCATCGCCAAGCTCCTGAAGGAGCACCAGGGCATCTTCACCTTCCTCTGCGAGATCTGCTTTGACAGTAAAC
CCCGGATCATCAGCAAAGGCACCAAGGACTCTCCGTCTGTCTGCTCCAACCTGGCTGCCAAGCACAGCTTCTACAACAACAAGTGCCTGG
TGCACATCGTCCGCTCCACCTCCCTCAAGTACTCCAAGATCCGCCAGTTCCAGGAGCACTTCCAGTTCGACGTGTGCCGCCATGAGGTGC
GCTACGGCTGCCTGCGGGAGGACAGCTGCCACTTCGCCCACAGCTTCATCGAGCTCAAGGTCTGGCTGCTGCAGCAGTACTCAGGCATGA
CCCACGAAGACATCGTTCAGGAGTCTAAGAAGTACTGGCAGCAGATGGAGGCGCATGCGGGGAAGGCCAGCAGCAGCATGGGTGCTCCGA
GGACACATGGGCCCAGCACCTTTGACCTGCAGATGAAGTTTGTATGTGGCCAGTGCTGGAGAAACGGGCAGGTGGTGGAGCCTGACAAGG
ACCTCAAGTACTGTAGTGCCAAGGCCCGGCACTGCTGGACCAAGGAGCGGCGGGTCCTTCTGGTGATGTCCAAGGCCAAGAGGAAATGGG
TGTCAGTGAGGCCACTGCCATCCATTCGTAACTTCCCACAGCAATACGATCTCTGCATCCATGCACAGAACGGCCGCAAGTGCCAATATG
TGGGGAACTGCTCCTTCGCACACAGCCCGGAGGAGAGGGACATGTGGACCTTCATGAAGGAGAACAAGATCCTGGACATGCAGCAGACCT
ATGACATGTGGCTGAAAAAACACAACCCAGGAAAGCCTGGAGAAGGGACCCCCATCAGTTCTCGGGAAGGGGAGAAGCAGATCCAGATGC
CCACGGACTACGCGGACATCATGATGGGCTACCACTGCTGGCTCTGCGGCAAGAACAGCAACAGCAAGAAGCAGTGGCAGCAGCACATCC
AGTCCGAGAAGCACAAGGAGAAGGTCTTCACGTCCGACAGTGACGCCAGCGGCTGGGCCTTCCGCTTCCCCATGGGCGAGTTCCGGCTCT
GCGACAGGCTCCAGAAGGGCAAAGCCTGCCCAGATGGGGACAAGTGCCGCTGCGCCCATGGACAGGAGGAGCTCAACGAGTGGCTGGACC
GGCGCGAGGTGCTGAAGCAGAAGTTGGCCAAGGCTCGCAAGGACATGCTGCTGTGCCCACGGGACGACGACTTTGGCAAATACAACTTCC
TGCTGCAAGAGGACGGGGACCTTGCCGGTGCCACCCCAGAAGCCCCTGCTGCTGCTGCCACCGCCACCACTGGGGAGTAGGGCCAGGTGT
TGGCCGTGGGTGAAGTCCTGGGGTCAGGGGGTGGGGTGGGGCCAGAAGGCCTGATAGAAGGGTCAGGGCAGGCCAGGGGGGTGGGGGGCC
GCCCTCATCAGGCAGCCCCCAGCCCCCTGAGGCCCTGTCCATCTTCTCCCCACCACCGCCCCGGTGTGCGTACCCAGGCGCACGTGCTGC
AGCCCCCGGAGGCCCCGCTGAAACCTGGGCTGCCCTTCCCCCACCCCCACGGCTCTCCTGGTTGAGGAGGGAGGGGCCTGGCTGACCCCT
CCAGCTTCAGCCTCCAGCTTTAACTTCTGTCTGCTCCTAATGGGGGCCCAAAGCTCAGGGCTGGGGAGCCTGGGGTCCCCACTTGAATCT
CCAGCAGGAGGGTCCTTCTCTCCCTGGCCCGTCCTCCTCCCACCCCCTCCCCCTGGGGGCAAATCAGGACACAACAGAGGGCAGAGGCCC
CATTAGCTTTAAAATGTAGCCCCAGGTTGGAGCTGGGAACACTGTACTGGCCACTTACCCTCTGGGGCCTCAGCTTTCCCTCCGGAAGGC
TGGGAGGAGGTGGGCTAGATGATCTTTGGAGCTTAAGGAGTCCCAGCCCTTTCTCTGATGCCACCACCTGAACCCTGCTCCCTCGTGGGC
CAGTGAAAATAGACTGTAGGTCCTCAGAGCCTTCAGAGATGATCCAGCCCAAACCCCATTTTGCAGAGAGGAAAACTGAGGCCTAGAAGG
GAGGAGTGGTCCACCCACGGTCCCAGCACAAGGCAGAGCTGGGATGAAAACAGGGCTGAAAAGACTCAGGGCCAATTATTGGCTGAGCCC
ACGGTCCCCTCAGCAGGGATGCGATGGTCTCTGAATCAGTGTGCAGCTGGGGTCCCAGGCAGCGCTGCCTGGGGGCTGGGGAGGGGAGGC
CCAGAGGAGGGCTGGCCATGTGAGCACCCCATGAAGGGACCGCCCCCTCCCAAGGATGGTCCCTTTGGGTGCAGCAGCAGAGGTCACCTC
CTGACATGCGCTCTGGGAAAGGTGGCAGAGGGCAGGACACCATGAGCTCAGGATCTGTGTGAGGTGTGGGAGGTGGGAAGGGTGAGGGTC
TGGGGGAATGCGGAGAAAAGGGAGGCTTGACCCCGGGCACCATGGGCCACTCCAGGATGGGACACGGCCCCTCTTTCTTGGGGACCCAGT
ATGTCCTCTCCTCTAGACCCAGACATACAGTTATAACCGTCTGTCCTAGCCCCTCCCTAATCCCTGGCCCTCCCAGCTGTCTGGGACTTC
AGTGGACCCCCAGCCCCTGCCCCCACTCACCAAGGCCTCGCTCGTCCCTCTCGTCTGACATGTCTGTGTGCACCCCCCTCCTCTCCACCC
TACCTTCCATCAACCAGGGCAGATCCACCGTGCCCTGGTTCCCCAGACATTCCAGAATGCCCCACATCATTGGCACAGGAGTGGGGCAGC
CCCGGAAGGAACCAGGGATTAGGCTGTAGGGGGGTGAGAAGGAGAGAAGGGACCACCCCATTCTTCTCAAGCAAGGATTGCCAGCGCGCG
CTGACACAGTGATGGGCTGCCCAGGGCTGGAGGGGACGCTGTTCCTCCCGCCGCCACTGCCCAACCTTTCCTGATAATCGTGGCATGCGC
CCTTTCCTCTTCCCTGCCCCACCCCCTGGCCGCAGCAGGCCAGCACTGCAGAGTTTGGGTGCTGGTGGTGTGGCTGTAGGGGAGGGGAGA
CCACACCCAAGGTGGGGGCTGTGGCCATGTGTGGCCGTGATGTCGATGATACTCGTTTTCCCTGATCCGTGGTGTTGCAGTCCGTTGTCA
CCAGCCTTGTTTCTAGTGTGTATATATGTCGCCCCCGTGATGCATATATACACAGGTATTAAATATATCGCTCTATATAATATTATATAT
GTGTGTGGTATCCAAGGAATCACTTTTATGAGGGCTAAAGATAAAGAATTTGGCCAGAAAATGCAGCCATCCTTGTGTGATTAGGAGGGT
TTCAGGGGCCACTGGACTATTTGCAAGGTGACAGGGACTGGAGCCATGGCTCAGAGGTGATTCGGGCAGCCAGGGACAGGAGCCACCCTC
CCCAGGCCCAACTCTGCTAGCTTCCCAGACCACCCCCATCGAGTGCGGAGAGAGTGGGAGTGCTCAGGGAAAGAAGGTGATTTGTATTTG
TCTCCCCGCTGAAAAGAACAGGATTCAAGTCCAGAGTTTTCATCTTCAGCCTGTGATCTGTCCAGGGACCCTTGGGATCTGGGGCTTCCT
GGCCTGGCCAGAGCTGGAGCCCCCACAGGGTAAGGAAGAGAGAGTGGGAGGCAGAGTGTGATGGGGAGGAGGGACAGGAAGACCCTTTTA
ATGATGAGGGTAACTATTTCAGTTGTGAGCCTTCTAGGGCCCCAGGCTGGGAGGCTCAGAGGACTGAATCTGGGACCTGTGTTCCCCCCG
GCAGGCAGGGACAAGATGGCATGGCAAGCATGGGGGCGGGGTGGGTGGGGAGGGATGCTGCATTTCTCAGCTGGGCAGTAATCAATTTAA
TGGTCCTTTAAAATGTCTGTGTATTAAAAATTTAAGAATACCACACTTTAATATTAAATATTCATAAGGTCTAGTATCTTGATAATAATG

>1359_1359_5_ACO2-ZC3H7B_ACO2_chr22_41865186_ENST00000396512_ZC3H7B_chr22_41738533_ENST00000351589_length(amino acids)=595AA_BP=16
LSVHKMAPYSLLVTRLQPEPCMPNTALLIKNPLAATHEFKQACQLCYPKTGPRAGDYTYREGLEHKCKRDILLGRLRSSEDQTWKRIRPR
PTKTSFVGSYYLCKDMINKQDCKYGDNCTFAYHQEEIDVWTEERKGTLNRDLLFDPLGGVKRGSLTIAKLLKEHQGIFTFLCEICFDSKP
RIISKGTKDSPSVCSNLAAKHSFYNNKCLVHIVRSTSLKYSKIRQFQEHFQFDVCRHEVRYGCLREDSCHFAHSFIELKVWLLQQYSGMT
HEDIVQESKKYWQQMEAHAGKASSSMGAPRTHGPSTFDLQMKFVCGQCWRNGQVVEPDKDLKYCSAKARHCWTKERRVLLVMSKAKRKWV
SVRPLPSIRNFPQQYDLCIHAQNGRKCQYVGNCSFAHSPEERDMWTFMKENKILDMQQTYDMWLKKHNPGKPGEGTPISSREGEKQIQMP
TDYADIMMGYHCWLCGKNSNSKKQWQQHIQSEKHKEKVFTSDSDASGWAFRFPMGEFRLCDRLQKGKACPDGDKCRCAHGQEELNEWLDR

--------------------------------------------------------------
>1359_1359_6_ACO2-ZC3H7B_ACO2_chr22_41865186_ENST00000396512_ZC3H7B_chr22_41738533_ENST00000352645_length(transcript)=4508nt_BP=53nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGCCAGAGCCCTGCATGCCCAACACTGCCTTGCTCATCA
AGAACCCCTTGGCTGCCACCCACGAGTTCAAGCAGGCCTGCCAGCTCTGCTACCCCAAGACAGGCCCCCGGGCTGGCGACTACACCTACC
GTGAGGGCCTTGAGCACAAGTGCAAGCGGGACATCCTGCTCGGCCGGCTCCGGAGCTCGGAGGACCAGACCTGGAAGCGGATCCGGCCCC
GGCCCACTAAGACCAGCTTCGTGGGCTCCTACTACCTGTGCAAAGACATGATTAACAAGCAGGACTGTAAGTACGGGGATAACTGCACCT
TCGCCTACCATCAGGAGGAGATCGACGTGTGGACCGAGGAGCGGAAGGGCACCCTCAACCGCGACCTGCTCTTCGACCCGCTGGGGGGTG
TTAAGCGCGGCAGCCTCACCATCGCCAAGCTCCTGAAGGAGCACCAGGGCATCTTCACCTTCCTCTGCGAGATCTGCTTTGACAGTAAAC
CCCGGATCATCAGCAAAGGCACCAAGGACTCTCCGTCTGTCTGCTCCAACCTGGCTGCCAAGCACAGCTTCTACAACAACAAGTGCCTGG
TGCACATCGTCCGCTCCACCTCCCTCAAGTACTCCAAGATCCGCCAGTTCCAGGAGCACTTCCAGTTCGACGTGTGCCGCCATGAGGTGC
GCTACGGCTGCCTGCGGGAGGACAGCTGCCACTTCGCCCACAGCTTCATCGAGCTCAAGGTCTGGCTGCTGCAGCAGTACTCAGGCATGA
CCCACGAAGACATCGTTCAGGAGTCTAAGAAGTACTGGCAGCAGATGGAGGCGCATGCGGGGAAGGCCAGCAGCAGCATGGGTGCTCCGA
GGACACATGGGCCCAGCACCTTTGACCTGCAGATGAAGTTTGTATGTGGCCAGTGCTGGAGAAACGGGCAGGTGGTGGAGCCTGACAAGG
ACCTCAAGTACTGTAGTGCCAAGGCCCGGCACTGCTGGACCAAGGAGCGGCGGGTCCTTCTGGTGATGTCCAAGGCCAAGAGGAAATGGG
TGTCAGTGAGGCCACTGCCATCCATTCGTAACTTCCCACAGCAATACGATCTCTGCATCCATGCACAGAACGGCCGCAAGTGCCAATATG
TGGGGAACTGCTCCTTCGCACACAGCCCGGAGGAGAGGGACATGTGGACCTTCATGAAGGAGAACAAGATCCTGGACATGCAGCAGACCT
ATGACATGTGGCTGAAAAAACACAACCCAGGAAAGCCTGGAGAAGGGACCCCCATCAGTTCTCGGGAAGGGGAGAAGCAGATCCAGATGC
CCACGGACTACGCGGACATCATGATGGGCTACCACTGCTGGCTCTGCGGCAAGAACAGCAACAGCAAGAAGCAGTGGCAGCAGCACATCC
AGTCCGAGAAGCACAAGGAGAAGGTCTTCACGTCCGACAGTGACGCCAGCGGCTGGGCCTTCCGCTTCCCCATGGGCGAGTTCCGGCTCT
GCGACAGGCTCCAGAAGGGCAAAGCCTGCCCAGATGGGGACAAGTGCCGCTGCGCCCATGGACAGGAGGAGCTCAACGAGTGGCTGGACC
GGCGCGAGGTGCTGAAGCAGAAGTTGGCCAAGGCTCGCAAGGACATGCTGCTGTGCCCACGGGACGACGACTTTGGCAAATACAACTTCC
TGCTGCAAGAGGACGGGGACCTTGCCGGTGCCACCCCAGAAGCCCCTGCTGCTGCTGCCACCGCCACCACTGGGGAGTAGGGCCAGGTGT
TGGCCGTGGGTGAAGTCCTGGGGTCAGGGGGTGGGGTGGGGCCAGAAGGCCTGATAGAAGGGTCAGGGCAGGCCAGGGGGGTGGGGGGCC
GCCCTCATCAGGCAGCCCCCAGCCCCCTGAGGCCCTGTCCATCTTCTCCCCACCACCGCCCCGGTGTGCGTACCCAGGCGCACGTGCTGC
AGCCCCCGGAGGCCCCGCTGAAACCTGGGCTGCCCTTCCCCCACCCCCACGGCTCTCCTGGTTGAGGAGGGAGGGGCCTGGCTGACCCCT
CCAGCTTCAGCCTCCAGCTTTAACTTCTGTCTGCTCCTAATGGGGGCCCAAAGCTCAGGGCTGGGGAGCCTGGGGTCCCCACTTGAATCT
CCAGCAGGAGGGTCCTTCTCTCCCTGGCCCGTCCTCCTCCCACCCCCTCCCCCTGGGGGCAAATCAGGACACAACAGAGGGCAGAGGCCC
CATTAGCTTTAAAATGTAGCCCCAGGTTGGAGCTGGGAACACTGTACTGGCCACTTACCCTCTGGGGCCTCAGCTTTCCCTCCGGAAGGC
TGGGAGGAGGTGGGCTAGATGATCTTTGGAGCTTAAGGAGTCCCAGCCCTTTCTCTGATGCCACCACCTGAACCCTGCTCCCTCGTGGGC
CAGTGAAAATAGACTGTAGGTCCTCAGAGCCTTCAGAGATGATCCAGCCCAAACCCCATTTTGCAGAGAGGAAAACTGAGGCCTAGAAGG
GAGGAGTGGTCCACCCACGGTCCCAGCACAAGGCAGAGCTGGGATGAAAACAGGGCTGAAAAGACTCAGGGCCAATTATTGGCTGAGCCC
ACGGTCCCCTCAGCAGGGATGCGATGGTCTCTGAATCAGTGTGCAGCTGGGGTCCCAGGCAGCGCTGCCTGGGGGCTGGGGAGGGGAGGC
CCAGAGGAGGGCTGGCCATGTGAGCACCCCATGAAGGGACCGCCCCCTCCCAAGGATGGTCCCTTTGGGTGCAGCAGCAGAGGTCACCTC
CTGACATGCGCTCTGGGAAAGGTGGCAGAGGGCAGGACACCATGAGCTCAGGATCTGTGTGAGGTGTGGGAGGTGGGAAGGGTGAGGGTC
TGGGGGAATGCGGAGAAAAGGGAGGCTTGACCCCGGGCACCATGGGCCACTCCAGGATGGGACACGGCCCCTCTTTCTTGGGGACCCAGT
ATGTCCTCTCCTCTAGACCCAGACATACAGTTATAACCGTCTGTCCTAGCCCCTCCCTAATCCCTGGCCCTCCCAGCTGTCTGGGACTTC
AGTGGACCCCCAGCCCCTGCCCCCACTCACCAAGGCCTCGCTCGTCCCTCTCGTCTGACATGTCTGTGTGCACCCCCCTCCTCTCCACCC
TACCTTCCATCAACCAGGGCAGATCCACCGTGCCCTGGTTCCCCAGACATTCCAGAATGCCCCACATCATTGGCACAGGAGTGGGGCAGC
CCCGGAAGGAACCAGGGATTAGGCTGTAGGGGGGTGAGAAGGAGAGAAGGGACCACCCCATTCTTCTCAAGCAAGGATTGCCAGCGCGCG
CTGACACAGTGATGGGCTGCCCAGGGCTGGAGGGGACGCTGTTCCTCCCGCCGCCACTGCCCAACCTTTCCTGATAATCGTGGCATGCGC
CCTTTCCTCTTCCCTGCCCCACCCCCTGGCCGCAGCAGGCCAGCACTGCAGAGTTTGGGTGCTGGTGGTGTGGCTGTAGGGGAGGGGAGA
CCACACCCAAGGTGGGGGCTGTGGCCATGTGTGGCCGTGATGTCGATGATACTCGTTTTCCCTGATCCGTGGTGTTGCAGTCCGTTGTCA
CCAGCCTTGTTTCTAGTGTGTATATATGTCGCCCCCGTGATGCATATATACACAGGTATTAAATATATCGCTCTATATAATATTATATAT
GTGTGTGGTATCCAAGGAATCACTTTTATGAGGGCTAAAGATAAAGAATTTGGCCAGAAAATGCAGCCATCCTTGTGTGATTAGGAGGGT
TTCAGGGGCCACTGGACTATTTGCAAGGTGACAGGGACTGGAGCCATGGCTCAGAGGTGATTCGGGCAGCCAGGGACAGGAGCCACCCTC
CCCAGGCCCAACTCTGCTAGCTTCCCAGACCACCCCCATCGAGTGCGGAGAGAGTGGGAGTGCTCAGGGAAAGAAGGTGATTTGTATTTG
TCTCCCCGCTGAAAAGAACAGGATTCAAGTCCAGAGTTTTCATCTTCAGCCTGTGATCTGTCCAGGGACCCTTGGGATCTGGGGCTTCCT
GGCCTGGCCAGAGCTGGAGCCCCCACAGGGTAAGGAAGAGAGAGTGGGAGGCAGAGTGTGATGGGGAGGAGGGACAGGAAGACCCTTTTA
ATGATGAGGGTAACTATTTCAGTTGTGAGCCTTCTAGGGCCCCAGGCTGGGAGGCTCAGAGGACTGAATCTGGGACCTGTGTTCCCCCCG
GCAGGCAGGGACAAGATGGCATGGCAAGCATGGGGGCGGGGTGGGTGGGGAGGGATGCTGCATTTCTCAGCTGGGCAGTAATCAATTTAA
TGGTCCTTTAAAATGTCTGTGTATTAAAAATTTAAGAATACCACACTTTAATATTAAATATTCATAAGGTCTAGTATCTTGATAATAATG
TAGATGTTTTAATAACAATTTTTGTCCTTCTTAAAATAAAATGAAAGAAACTTGCTTCCCTTAGCCTTTGTTCTAGAAAATAAACTTGTG

>1359_1359_6_ACO2-ZC3H7B_ACO2_chr22_41865186_ENST00000396512_ZC3H7B_chr22_41738533_ENST00000352645_length(amino acids)=595AA_BP=16
LSVHKMAPYSLLVTRLQPEPCMPNTALLIKNPLAATHEFKQACQLCYPKTGPRAGDYTYREGLEHKCKRDILLGRLRSSEDQTWKRIRPR
PTKTSFVGSYYLCKDMINKQDCKYGDNCTFAYHQEEIDVWTEERKGTLNRDLLFDPLGGVKRGSLTIAKLLKEHQGIFTFLCEICFDSKP
RIISKGTKDSPSVCSNLAAKHSFYNNKCLVHIVRSTSLKYSKIRQFQEHFQFDVCRHEVRYGCLREDSCHFAHSFIELKVWLLQQYSGMT
HEDIVQESKKYWQQMEAHAGKASSSMGAPRTHGPSTFDLQMKFVCGQCWRNGQVVEPDKDLKYCSAKARHCWTKERRVLLVMSKAKRKWV
SVRPLPSIRNFPQQYDLCIHAQNGRKCQYVGNCSFAHSPEERDMWTFMKENKILDMQQTYDMWLKKHNPGKPGEGTPISSREGEKQIQMP
TDYADIMMGYHCWLCGKNSNSKKQWQQHIQSEKHKEKVFTSDSDASGWAFRFPMGEFRLCDRLQKGKACPDGDKCRCAHGQEELNEWLDR

--------------------------------------------------------------
>1359_1359_7_ACO2-ZC3H7B_ACO2_chr22_41865186_ENST00000396512_ZC3H7B_chr22_41751473_ENST00000351589_length(transcript)=3627nt_BP=53nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGGGTGCTCCGAGGACACATGGGCCCAGCACCTTTGACC
TGCAGATGAAGTTTGTATGTGGCCAGTGCTGGAGAAACGGGCAGGTGGTGGAGCCTGACAAGGACCTCAAGTACTGTAGTGCCAAGGCCC
GGCACTGCTGGACCAAGGAGCGGCGGGTCCTTCTGGTGATGTCCAAGGCCAAGAGGAAATGGGTGTCAGTGAGGCCACTGCCATCCATTC
GTAACTTCCCACAGCAATACGATCTCTGCATCCATGCACAGAACGGCCGCAAGTGCCAATATGTGGGGAACTGCTCCTTCGCACACAGCC
CGGAGGAGAGGGACATGTGGACCTTCATGAAGGAGAACAAGATCCTGGACATGCAGCAGACCTATGACATGTGGCTGAAAAAACACAACC
CAGGAAAGCCTGGAGAAGGGACCCCCATCAGTTCTCGGGAAGGGGAGAAGCAGATCCAGATGCCCACGGACTACGCGGACATCATGATGG
GCTACCACTGCTGGCTCTGCGGCAAGAACAGCAACAGCAAGAAGCAGTGGCAGCAGCACATCCAGTCCGAGAAGCACAAGGAGAAGGTCT
TCACGTCCGACAGTGACGCCAGCGGCTGGGCCTTCCGCTTCCCCATGGGCGAGTTCCGGCTCTGCGACAGGCTCCAGAAGGGCAAAGCCT
GCCCAGATGGGGACAAGTGCCGCTGCGCCCATGGACAGGAGGAGCTCAACGAGTGGCTGGACCGGCGCGAGGTGCTGAAGCAGAAGTTGG
CCAAGGCTCGCAAGGACATGCTGCTGTGCCCACGGGACGACGACTTTGGCAAATACAACTTCCTGCTGCAAGAGGACGGGGACCTTGCCG
GTGCCACCCCAGAAGCCCCTGCTGCTGCTGCCACCGCCACCACTGGGGAGTAGGGCCAGGTGTTGGCCGTGGGTGAAGTCCTGGGGTCAG
GGGGTGGGGTGGGGCCAGAAGGCCTGATAGAAGGGTCAGGGCAGGCCAGGGGGGTGGGGGGCCGCCCTCATCAGGCAGCCCCCAGCCCCC
TGAGGCCCTGTCCATCTTCTCCCCACCACCGCCCCGGTGTGCGTACCCAGGCGCACGTGCTGCAGCCCCCGGAGGCCCCGCTGAAACCTG
GGCTGCCCTTCCCCCACCCCCACGGCTCTCCTGGTTGAGGAGGGAGGGGCCTGGCTGACCCCTCCAGCTTCAGCCTCCAGCTTTAACTTC
TGTCTGCTCCTAATGGGGGCCCAAAGCTCAGGGCTGGGGAGCCTGGGGTCCCCACTTGAATCTCCAGCAGGAGGGTCCTTCTCTCCCTGG
CCCGTCCTCCTCCCACCCCCTCCCCCTGGGGGCAAATCAGGACACAACAGAGGGCAGAGGCCCCATTAGCTTTAAAATGTAGCCCCAGGT
TGGAGCTGGGAACACTGTACTGGCCACTTACCCTCTGGGGCCTCAGCTTTCCCTCCGGAAGGCTGGGAGGAGGTGGGCTAGATGATCTTT
GGAGCTTAAGGAGTCCCAGCCCTTTCTCTGATGCCACCACCTGAACCCTGCTCCCTCGTGGGCCAGTGAAAATAGACTGTAGGTCCTCAG
AGCCTTCAGAGATGATCCAGCCCAAACCCCATTTTGCAGAGAGGAAAACTGAGGCCTAGAAGGGAGGAGTGGTCCACCCACGGTCCCAGC
ACAAGGCAGAGCTGGGATGAAAACAGGGCTGAAAAGACTCAGGGCCAATTATTGGCTGAGCCCACGGTCCCCTCAGCAGGGATGCGATGG
TCTCTGAATCAGTGTGCAGCTGGGGTCCCAGGCAGCGCTGCCTGGGGGCTGGGGAGGGGAGGCCCAGAGGAGGGCTGGCCATGTGAGCAC
CCCATGAAGGGACCGCCCCCTCCCAAGGATGGTCCCTTTGGGTGCAGCAGCAGAGGTCACCTCCTGACATGCGCTCTGGGAAAGGTGGCA
GAGGGCAGGACACCATGAGCTCAGGATCTGTGTGAGGTGTGGGAGGTGGGAAGGGTGAGGGTCTGGGGGAATGCGGAGAAAAGGGAGGCT
TGACCCCGGGCACCATGGGCCACTCCAGGATGGGACACGGCCCCTCTTTCTTGGGGACCCAGTATGTCCTCTCCTCTAGACCCAGACATA
CAGTTATAACCGTCTGTCCTAGCCCCTCCCTAATCCCTGGCCCTCCCAGCTGTCTGGGACTTCAGTGGACCCCCAGCCCCTGCCCCCACT
CACCAAGGCCTCGCTCGTCCCTCTCGTCTGACATGTCTGTGTGCACCCCCCTCCTCTCCACCCTACCTTCCATCAACCAGGGCAGATCCA
CCGTGCCCTGGTTCCCCAGACATTCCAGAATGCCCCACATCATTGGCACAGGAGTGGGGCAGCCCCGGAAGGAACCAGGGATTAGGCTGT
AGGGGGGTGAGAAGGAGAGAAGGGACCACCCCATTCTTCTCAAGCAAGGATTGCCAGCGCGCGCTGACACAGTGATGGGCTGCCCAGGGC
TGGAGGGGACGCTGTTCCTCCCGCCGCCACTGCCCAACCTTTCCTGATAATCGTGGCATGCGCCCTTTCCTCTTCCCTGCCCCACCCCCT
GGCCGCAGCAGGCCAGCACTGCAGAGTTTGGGTGCTGGTGGTGTGGCTGTAGGGGAGGGGAGACCACACCCAAGGTGGGGGCTGTGGCCA
TGTGTGGCCGTGATGTCGATGATACTCGTTTTCCCTGATCCGTGGTGTTGCAGTCCGTTGTCACCAGCCTTGTTTCTAGTGTGTATATAT
GTCGCCCCCGTGATGCATATATACACAGGTATTAAATATATCGCTCTATATAATATTATATATGTGTGTGGTATCCAAGGAATCACTTTT
ATGAGGGCTAAAGATAAAGAATTTGGCCAGAAAATGCAGCCATCCTTGTGTGATTAGGAGGGTTTCAGGGGCCACTGGACTATTTGCAAG
GTGACAGGGACTGGAGCCATGGCTCAGAGGTGATTCGGGCAGCCAGGGACAGGAGCCACCCTCCCCAGGCCCAACTCTGCTAGCTTCCCA
GACCACCCCCATCGAGTGCGGAGAGAGTGGGAGTGCTCAGGGAAAGAAGGTGATTTGTATTTGTCTCCCCGCTGAAAAGAACAGGATTCA
AGTCCAGAGTTTTCATCTTCAGCCTGTGATCTGTCCAGGGACCCTTGGGATCTGGGGCTTCCTGGCCTGGCCAGAGCTGGAGCCCCCACA
GGGTAAGGAAGAGAGAGTGGGAGGCAGAGTGTGATGGGGAGGAGGGACAGGAAGACCCTTTTAATGATGAGGGTAACTATTTCAGTTGTG
AGCCTTCTAGGGCCCCAGGCTGGGAGGCTCAGAGGACTGAATCTGGGACCTGTGTTCCCCCCGGCAGGCAGGGACAAGATGGCATGGCAA
GCATGGGGGCGGGGTGGGTGGGGAGGGATGCTGCATTTCTCAGCTGGGCAGTAATCAATTTAATGGTCCTTTAAAATGTCTGTGTATTAA
AAATTTAAGAATACCACACTTTAATATTAAATATTCATAAGGTCTAGTATCTTGATAATAATGTAGATGTTTTAATAACAATTTTTGTCC

>1359_1359_7_ACO2-ZC3H7B_ACO2_chr22_41865186_ENST00000396512_ZC3H7B_chr22_41751473_ENST00000351589_length(amino acids)=316AA_BP=16
LSVHKMAPYSLLVTRLQGAPRTHGPSTFDLQMKFVCGQCWRNGQVVEPDKDLKYCSAKARHCWTKERRVLLVMSKAKRKWVSVRPLPSIR
NFPQQYDLCIHAQNGRKCQYVGNCSFAHSPEERDMWTFMKENKILDMQQTYDMWLKKHNPGKPGEGTPISSREGEKQIQMPTDYADIMMG
YHCWLCGKNSNSKKQWQQHIQSEKHKEKVFTSDSDASGWAFRFPMGEFRLCDRLQKGKACPDGDKCRCAHGQEELNEWLDRREVLKQKLA

--------------------------------------------------------------
>1359_1359_8_ACO2-ZC3H7B_ACO2_chr22_41865186_ENST00000396512_ZC3H7B_chr22_41751473_ENST00000352645_length(transcript)=3671nt_BP=53nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGGGTGCTCCGAGGACACATGGGCCCAGCACCTTTGACC
TGCAGATGAAGTTTGTATGTGGCCAGTGCTGGAGAAACGGGCAGGTGGTGGAGCCTGACAAGGACCTCAAGTACTGTAGTGCCAAGGCCC
GGCACTGCTGGACCAAGGAGCGGCGGGTCCTTCTGGTGATGTCCAAGGCCAAGAGGAAATGGGTGTCAGTGAGGCCACTGCCATCCATTC
GTAACTTCCCACAGCAATACGATCTCTGCATCCATGCACAGAACGGCCGCAAGTGCCAATATGTGGGGAACTGCTCCTTCGCACACAGCC
CGGAGGAGAGGGACATGTGGACCTTCATGAAGGAGAACAAGATCCTGGACATGCAGCAGACCTATGACATGTGGCTGAAAAAACACAACC
CAGGAAAGCCTGGAGAAGGGACCCCCATCAGTTCTCGGGAAGGGGAGAAGCAGATCCAGATGCCCACGGACTACGCGGACATCATGATGG
GCTACCACTGCTGGCTCTGCGGCAAGAACAGCAACAGCAAGAAGCAGTGGCAGCAGCACATCCAGTCCGAGAAGCACAAGGAGAAGGTCT
TCACGTCCGACAGTGACGCCAGCGGCTGGGCCTTCCGCTTCCCCATGGGCGAGTTCCGGCTCTGCGACAGGCTCCAGAAGGGCAAAGCCT
GCCCAGATGGGGACAAGTGCCGCTGCGCCCATGGACAGGAGGAGCTCAACGAGTGGCTGGACCGGCGCGAGGTGCTGAAGCAGAAGTTGG
CCAAGGCTCGCAAGGACATGCTGCTGTGCCCACGGGACGACGACTTTGGCAAATACAACTTCCTGCTGCAAGAGGACGGGGACCTTGCCG
GTGCCACCCCAGAAGCCCCTGCTGCTGCTGCCACCGCCACCACTGGGGAGTAGGGCCAGGTGTTGGCCGTGGGTGAAGTCCTGGGGTCAG
GGGGTGGGGTGGGGCCAGAAGGCCTGATAGAAGGGTCAGGGCAGGCCAGGGGGGTGGGGGGCCGCCCTCATCAGGCAGCCCCCAGCCCCC
TGAGGCCCTGTCCATCTTCTCCCCACCACCGCCCCGGTGTGCGTACCCAGGCGCACGTGCTGCAGCCCCCGGAGGCCCCGCTGAAACCTG
GGCTGCCCTTCCCCCACCCCCACGGCTCTCCTGGTTGAGGAGGGAGGGGCCTGGCTGACCCCTCCAGCTTCAGCCTCCAGCTTTAACTTC
TGTCTGCTCCTAATGGGGGCCCAAAGCTCAGGGCTGGGGAGCCTGGGGTCCCCACTTGAATCTCCAGCAGGAGGGTCCTTCTCTCCCTGG
CCCGTCCTCCTCCCACCCCCTCCCCCTGGGGGCAAATCAGGACACAACAGAGGGCAGAGGCCCCATTAGCTTTAAAATGTAGCCCCAGGT
TGGAGCTGGGAACACTGTACTGGCCACTTACCCTCTGGGGCCTCAGCTTTCCCTCCGGAAGGCTGGGAGGAGGTGGGCTAGATGATCTTT
GGAGCTTAAGGAGTCCCAGCCCTTTCTCTGATGCCACCACCTGAACCCTGCTCCCTCGTGGGCCAGTGAAAATAGACTGTAGGTCCTCAG
AGCCTTCAGAGATGATCCAGCCCAAACCCCATTTTGCAGAGAGGAAAACTGAGGCCTAGAAGGGAGGAGTGGTCCACCCACGGTCCCAGC
ACAAGGCAGAGCTGGGATGAAAACAGGGCTGAAAAGACTCAGGGCCAATTATTGGCTGAGCCCACGGTCCCCTCAGCAGGGATGCGATGG
TCTCTGAATCAGTGTGCAGCTGGGGTCCCAGGCAGCGCTGCCTGGGGGCTGGGGAGGGGAGGCCCAGAGGAGGGCTGGCCATGTGAGCAC
CCCATGAAGGGACCGCCCCCTCCCAAGGATGGTCCCTTTGGGTGCAGCAGCAGAGGTCACCTCCTGACATGCGCTCTGGGAAAGGTGGCA
GAGGGCAGGACACCATGAGCTCAGGATCTGTGTGAGGTGTGGGAGGTGGGAAGGGTGAGGGTCTGGGGGAATGCGGAGAAAAGGGAGGCT
TGACCCCGGGCACCATGGGCCACTCCAGGATGGGACACGGCCCCTCTTTCTTGGGGACCCAGTATGTCCTCTCCTCTAGACCCAGACATA
CAGTTATAACCGTCTGTCCTAGCCCCTCCCTAATCCCTGGCCCTCCCAGCTGTCTGGGACTTCAGTGGACCCCCAGCCCCTGCCCCCACT
CACCAAGGCCTCGCTCGTCCCTCTCGTCTGACATGTCTGTGTGCACCCCCCTCCTCTCCACCCTACCTTCCATCAACCAGGGCAGATCCA
CCGTGCCCTGGTTCCCCAGACATTCCAGAATGCCCCACATCATTGGCACAGGAGTGGGGCAGCCCCGGAAGGAACCAGGGATTAGGCTGT
AGGGGGGTGAGAAGGAGAGAAGGGACCACCCCATTCTTCTCAAGCAAGGATTGCCAGCGCGCGCTGACACAGTGATGGGCTGCCCAGGGC
TGGAGGGGACGCTGTTCCTCCCGCCGCCACTGCCCAACCTTTCCTGATAATCGTGGCATGCGCCCTTTCCTCTTCCCTGCCCCACCCCCT
GGCCGCAGCAGGCCAGCACTGCAGAGTTTGGGTGCTGGTGGTGTGGCTGTAGGGGAGGGGAGACCACACCCAAGGTGGGGGCTGTGGCCA
TGTGTGGCCGTGATGTCGATGATACTCGTTTTCCCTGATCCGTGGTGTTGCAGTCCGTTGTCACCAGCCTTGTTTCTAGTGTGTATATAT
GTCGCCCCCGTGATGCATATATACACAGGTATTAAATATATCGCTCTATATAATATTATATATGTGTGTGGTATCCAAGGAATCACTTTT
ATGAGGGCTAAAGATAAAGAATTTGGCCAGAAAATGCAGCCATCCTTGTGTGATTAGGAGGGTTTCAGGGGCCACTGGACTATTTGCAAG
GTGACAGGGACTGGAGCCATGGCTCAGAGGTGATTCGGGCAGCCAGGGACAGGAGCCACCCTCCCCAGGCCCAACTCTGCTAGCTTCCCA
GACCACCCCCATCGAGTGCGGAGAGAGTGGGAGTGCTCAGGGAAAGAAGGTGATTTGTATTTGTCTCCCCGCTGAAAAGAACAGGATTCA
AGTCCAGAGTTTTCATCTTCAGCCTGTGATCTGTCCAGGGACCCTTGGGATCTGGGGCTTCCTGGCCTGGCCAGAGCTGGAGCCCCCACA
GGGTAAGGAAGAGAGAGTGGGAGGCAGAGTGTGATGGGGAGGAGGGACAGGAAGACCCTTTTAATGATGAGGGTAACTATTTCAGTTGTG
AGCCTTCTAGGGCCCCAGGCTGGGAGGCTCAGAGGACTGAATCTGGGACCTGTGTTCCCCCCGGCAGGCAGGGACAAGATGGCATGGCAA
GCATGGGGGCGGGGTGGGTGGGGAGGGATGCTGCATTTCTCAGCTGGGCAGTAATCAATTTAATGGTCCTTTAAAATGTCTGTGTATTAA
AAATTTAAGAATACCACACTTTAATATTAAATATTCATAAGGTCTAGTATCTTGATAATAATGTAGATGTTTTAATAACAATTTTTGTCC

>1359_1359_8_ACO2-ZC3H7B_ACO2_chr22_41865186_ENST00000396512_ZC3H7B_chr22_41751473_ENST00000352645_length(amino acids)=316AA_BP=16
LSVHKMAPYSLLVTRLQGAPRTHGPSTFDLQMKFVCGQCWRNGQVVEPDKDLKYCSAKARHCWTKERRVLLVMSKAKRKWVSVRPLPSIR
NFPQQYDLCIHAQNGRKCQYVGNCSFAHSPEERDMWTFMKENKILDMQQTYDMWLKKHNPGKPGEGTPISSREGEKQIQMPTDYADIMMG
YHCWLCGKNSNSKKQWQQHIQSEKHKEKVFTSDSDASGWAFRFPMGEFRLCDRLQKGKACPDGDKCRCAHGQEELNEWLDRREVLKQKLA

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Fusion Gene PPI Analysis for ACO2-ZC3H7B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACO2-ZC3H7B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACO2-ZC3H7B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACO2C3281192INFANTILE CEREBELLAR-RETINAL DEGENERATION2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneACO2C4225384OPTIC ATROPHY 92CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneACO2C0035222Respiratory Distress Syndrome, Adult1CTD_human
HgeneACO2C2239176Liver carcinoma1CTD_human