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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADIPOR1-RGS8 (FusionGDB2 ID:HG51094TG85397)

Fusion Gene Summary for ADIPOR1-RGS8

check button Fusion gene summary
Fusion gene informationFusion gene name: ADIPOR1-RGS8
Fusion gene ID: hg51094tg85397
HgeneTgene
Gene symbol

ADIPOR1

RGS8

Gene ID

51094

85397

Gene nameadiponectin receptor 1regulator of G protein signaling 8
SynonymsACDCR1|CGI-45|CGI45|PAQR1|TESBP1A-
Cytomap('ADIPOR1')('RGS8')

1q32.1

1q25.3

Type of geneprotein-codingprotein-coding
Descriptionadiponectin receptor protein 1progestin and adipoQ receptor family member 1progestin and adipoQ receptor family member Iregulator of G-protein signaling 8regulator of G-protein signalling 8
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000340990, ENST00000436244, 
ENST00000367254, 
Fusion gene scores* DoF score4 X 5 X 2=402 X 2 X 2=8
# samples 42
** MAII scorelog2(4/40*10)=0log2(2/8*10)=1.32192809488736
Context

PubMed: ADIPOR1 [Title/Abstract] AND RGS8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADIPOR1(202912886)-RGS8(182617438), # samples:3
Anticipated loss of major functional domain due to fusion event.ADIPOR1-RGS8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADIPOR1-RGS8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADIPOR1-RGS8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ADIPOR1-RGS8 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ADIPOR1-RGS8 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADIPOR1

GO:0009755

hormone-mediated signaling pathway

12802337

HgeneADIPOR1

GO:0019395

fatty acid oxidation

12802337

HgeneADIPOR1

GO:0033211

adiponectin-activated signaling pathway

12802337

TgeneRGS8

GO:0043547

positive regulation of GTPase activity

18434541


check buttonFusion gene breakpoints across ADIPOR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RGS8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A243-01AADIPOR1chr1

202912886

-RGS8chr1

182617438

-


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Fusion Gene ORF analysis for ADIPOR1-RGS8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000340990ENST00000491420ADIPOR1chr1

202912886

-RGS8chr1

182617438

-
5CDS-intronENST00000436244ENST00000491420ADIPOR1chr1

202912886

-RGS8chr1

182617438

-
Frame-shiftENST00000436244ENST00000258302ADIPOR1chr1

202912886

-RGS8chr1

182617438

-
Frame-shiftENST00000436244ENST00000367556ADIPOR1chr1

202912886

-RGS8chr1

182617438

-
Frame-shiftENST00000436244ENST00000367557ADIPOR1chr1

202912886

-RGS8chr1

182617438

-
Frame-shiftENST00000436244ENST00000483095ADIPOR1chr1

202912886

-RGS8chr1

182617438

-
In-frameENST00000340990ENST00000258302ADIPOR1chr1

202912886

-RGS8chr1

182617438

-
In-frameENST00000340990ENST00000367556ADIPOR1chr1

202912886

-RGS8chr1

182617438

-
In-frameENST00000340990ENST00000367557ADIPOR1chr1

202912886

-RGS8chr1

182617438

-
In-frameENST00000340990ENST00000483095ADIPOR1chr1

202912886

-RGS8chr1

182617438

-
intron-3CDSENST00000367254ENST00000258302ADIPOR1chr1

202912886

-RGS8chr1

182617438

-
intron-3CDSENST00000367254ENST00000367556ADIPOR1chr1

202912886

-RGS8chr1

182617438

-
intron-3CDSENST00000367254ENST00000367557ADIPOR1chr1

202912886

-RGS8chr1

182617438

-
intron-3CDSENST00000367254ENST00000483095ADIPOR1chr1

202912886

-RGS8chr1

182617438

-
intron-intronENST00000367254ENST00000491420ADIPOR1chr1

202912886

-RGS8chr1

182617438

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000340990ADIPOR1chr1202912886-ENST00000483095RGS8chr1182617438-208511042991453384
ENST00000340990ADIPOR1chr1202912886-ENST00000258302RGS8chr1182617438-153211042991453384
ENST00000340990ADIPOR1chr1202912886-ENST00000367557RGS8chr1182617438-150311042991453384
ENST00000340990ADIPOR1chr1202912886-ENST00000367556RGS8chr1182617438-145411042991453385

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340990ENST00000483095ADIPOR1chr1202912886-RGS8chr1182617438-0.0036007280.9963993
ENST00000340990ENST00000258302ADIPOR1chr1202912886-RGS8chr1182617438-0.0062019480.9937981
ENST00000340990ENST00000367557ADIPOR1chr1202912886-RGS8chr1182617438-0.0065632170.99343675
ENST00000340990ENST00000367556ADIPOR1chr1202912886-RGS8chr1182617438-0.0058510670.99414897

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Fusion Genomic Features for ADIPOR1-RGS8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ADIPOR1-RGS8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:202912886/chr1:182617438)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68158_170268376.0Topological domainExtracellular
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68192_203268376.0Topological domainCytoplasmic
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-681_136268376.0Topological domainCytoplasmic
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68225_234268376.0Topological domainExtracellular
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68256_264268376.0Topological domainCytoplasmic
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79158_170268376.0Topological domainExtracellular
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79192_203268376.0Topological domainCytoplasmic
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-791_136268376.0Topological domainCytoplasmic
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79225_234268376.0Topological domainExtracellular
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79256_264268376.0Topological domainCytoplasmic
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68137_157268376.0TransmembraneHelical%3B Name%3D1
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68171_191268376.0TransmembraneHelical%3B Name%3D2
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68204_224268376.0TransmembraneHelical%3B Name%3D3
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68235_255268376.0TransmembraneHelical%3B Name%3D4
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79137_157268376.0TransmembraneHelical%3B Name%3D1
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79171_191268376.0TransmembraneHelical%3B Name%3D2
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79204_224268376.0TransmembraneHelical%3B Name%3D3
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79235_255268376.0TransmembraneHelical%3B Name%3D4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68286_298268376.0Topological domainExtracellular
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68320_337268376.0Topological domainCytoplasmic
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68359_375268376.0Topological domainExtracellular
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79286_298268376.0Topological domainExtracellular
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79320_337268376.0Topological domainCytoplasmic
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79359_375268376.0Topological domainExtracellular
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68265_285268376.0TransmembraneHelical%3B Name%3D5
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68299_319268376.0TransmembraneHelical%3B Name%3D6
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68338_358268376.0TransmembraneHelical%3B Name%3D7
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79265_285268376.0TransmembraneHelical%3B Name%3D5
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79299_319268376.0TransmembraneHelical%3B Name%3D6
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79338_358268376.0TransmembraneHelical%3B Name%3D7
TgeneRGS8chr1:202912886chr1:182617438ENST000002583023656_17182199.0DomainRGS
TgeneRGS8chr1:202912886chr1:182617438ENST000003675563656_17164181.0DomainRGS
TgeneRGS8chr1:202912886chr1:182617438ENST000003675574756_17164181.0DomainRGS
TgeneRGS8chr1:202912886chr1:182617438ENST000004830954756_17164181.0DomainRGS


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Fusion Gene Sequence for ADIPOR1-RGS8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2439_2439_1_ADIPOR1-RGS8_ADIPOR1_chr1_202912886_ENST00000340990_RGS8_chr1_182617438_ENST00000258302_length(transcript)=1532nt_BP=1104nt
CTCCGCGAGAGGGCCTAGGATTGGAGGGCCCAGGCAGAGCCCGCGAGGAGGTGACGCGGCTGCGGAGGTGACGCGGGAGGTCGCGCGCCC
CTTCCGGCGCGGGGAGGGCGCTGAAGATCGGGGCCGCTCGGCCGCAGGCCGCCTCCAGCGCCGCGGGATGTAGCGCGGGGGACCGCGGCC
CCCAGCAGAGCCCGCCTGCCCGGCTTGTCTACCATCAGAGGGAGATCTCTGCCCCCTGGGGCTGAGAGACCCCAACCTTTCCCCAAGCTG
AAGCTGCAGGGTATTGAGGTACCAGCCAGATGTCTTCCCACAAAGGATCTGTGGTGGCACAGGGGAATGGGGCTCCTGCCAGTAACAGGG
AAGCTGACACGGTGGAACTGGCTGAACTGGGACCCCTGCTAGAAGAGAAGGGCAAACGGGTAATCGCCAACCCACCCAAAGCTGAAGAAG
AGCAAACATGCCCAGTGCCCCAGGAAGAAGAGGAGGAGGTGCGGGTACTGACACTTCCCCTGCAAGCCCACCACGCCATGGAGAAGATGG
AAGAGTTTGTGTACAAGGTCTGGGAGGGACGTTGGAGGGTCATCCCATATGATGTGCTCCCTGACTGGCTAAAGGACAACGACTATCTGC
TACATGGTCATAGACCTCCCATGCCCTCCTTTCGGGCTTGCTTCAAGAGCATCTTCCGCATTCATACAGAAACTGGCAACATCTGGACCC
ATCTGCTTGGTTTCGTGCTGTTTCTCTTTTTGGGAATCTTGACCATGCTCAGACCAAATATGTACTTCATGGCCCCTCTACAGGAGAAGG
TGGTTTTTGGGATGTTCTTTTTGGGTGCAGTGCTCTGCCTCAGCTTCTCCTGGCTCTTTCACACCGTCTATTGTCATTCAGAGAAAGTCT
CTCGGACTTTTTCCAAACTGGACTATTCAGGGATTGCTCTTCTAATTATGGGGAGCTTTGTCCCCTGGCTCTATTATTCCTTCTACTGCT
CCCCACAGCCACGGCTCATCTACCTCTCCATCGTCTGTGTCCTGGGCATTTCTGCCATCATTGTGGCGCAGTGGGACCGGTTTGCCACTC
CTAAGCACCGGCAGACAAGAGCAGATGGGGTGGCTGCATTCCGTGCCTTCTTGAAGACGGAGTTCAGTGAGGAGAACCTGGAATTCTGGT
TGGCCTGTGAGGAGTTCAAGAAGACCAGGTCAACTGCAAAACTGGTCTCTAAGGCCCATAGGATCTTTGAGGAGTTTGTGGATGTGCAGG
CTCCACGGGAGGTAAACATTGACTTCCAGACCCGAGAAGCCACGAGGAAGAACCTGCAGGAGCCATCCCTGACTTGCTTTGACCAAGCCC
AAGGAAAAGTACACAGCCTCATGGAGAAAGACTCTTACCCCAGGTTCCTGAGGTCCAAAATGTACTTAGATCTGCTGTCCCAAAGCCAGA
GGAGGCTCAGTTAGACCTCAGAAGGGAACTCCTGGAAATCACCGGCTTTCCCCTCCACTTGCTGCCAAGATCATATTCTAATGTGAAATG

>2439_2439_1_ADIPOR1-RGS8_ADIPOR1_chr1_202912886_ENST00000340990_RGS8_chr1_182617438_ENST00000258302_length(amino acids)=384AA_BP=265
MSSHKGSVVAQGNGAPASNREADTVELAELGPLLEEKGKRVIANPPKAEEEQTCPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEG
RWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGA
VLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRADG
VAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEK

--------------------------------------------------------------
>2439_2439_2_ADIPOR1-RGS8_ADIPOR1_chr1_202912886_ENST00000340990_RGS8_chr1_182617438_ENST00000367556_length(transcript)=1454nt_BP=1104nt
CTCCGCGAGAGGGCCTAGGATTGGAGGGCCCAGGCAGAGCCCGCGAGGAGGTGACGCGGCTGCGGAGGTGACGCGGGAGGTCGCGCGCCC
CTTCCGGCGCGGGGAGGGCGCTGAAGATCGGGGCCGCTCGGCCGCAGGCCGCCTCCAGCGCCGCGGGATGTAGCGCGGGGGACCGCGGCC
CCCAGCAGAGCCCGCCTGCCCGGCTTGTCTACCATCAGAGGGAGATCTCTGCCCCCTGGGGCTGAGAGACCCCAACCTTTCCCCAAGCTG
AAGCTGCAGGGTATTGAGGTACCAGCCAGATGTCTTCCCACAAAGGATCTGTGGTGGCACAGGGGAATGGGGCTCCTGCCAGTAACAGGG
AAGCTGACACGGTGGAACTGGCTGAACTGGGACCCCTGCTAGAAGAGAAGGGCAAACGGGTAATCGCCAACCCACCCAAAGCTGAAGAAG
AGCAAACATGCCCAGTGCCCCAGGAAGAAGAGGAGGAGGTGCGGGTACTGACACTTCCCCTGCAAGCCCACCACGCCATGGAGAAGATGG
AAGAGTTTGTGTACAAGGTCTGGGAGGGACGTTGGAGGGTCATCCCATATGATGTGCTCCCTGACTGGCTAAAGGACAACGACTATCTGC
TACATGGTCATAGACCTCCCATGCCCTCCTTTCGGGCTTGCTTCAAGAGCATCTTCCGCATTCATACAGAAACTGGCAACATCTGGACCC
ATCTGCTTGGTTTCGTGCTGTTTCTCTTTTTGGGAATCTTGACCATGCTCAGACCAAATATGTACTTCATGGCCCCTCTACAGGAGAAGG
TGGTTTTTGGGATGTTCTTTTTGGGTGCAGTGCTCTGCCTCAGCTTCTCCTGGCTCTTTCACACCGTCTATTGTCATTCAGAGAAAGTCT
CTCGGACTTTTTCCAAACTGGACTATTCAGGGATTGCTCTTCTAATTATGGGGAGCTTTGTCCCCTGGCTCTATTATTCCTTCTACTGCT
CCCCACAGCCACGGCTCATCTACCTCTCCATCGTCTGTGTCCTGGGCATTTCTGCCATCATTGTGGCGCAGTGGGACCGGTTTGCCACTC
CTAAGCACCGGCAGACAAGAGCAGATGGGGTGGCTGCATTCCGTGCCTTCTTGAAGACGGAGTTCAGTGAGGAGAACCTGGAATTCTGGT
TGGCCTGTGAGGAGTTCAAGAAGACCAGGTCAACTGCAAAACTGGTCTCTAAGGCCCATAGGATCTTTGAGGAGTTTGTGGATGTGCAGG
CTCCACGGGAGGTAAACATTGACTTCCAGACCCGAGAAGCCACGAGGAAGAACCTGCAGGAGCCATCCCTGACTTGCTTTGACCAAGCCC
AAGGAAAAGTACACAGCCTCATGGAGAAAGACTCTTACCCCAGGTTCCTGAGGTCCAAAATGTACTTAGATCTGCTGTCCCAAAGCCAGA

>2439_2439_2_ADIPOR1-RGS8_ADIPOR1_chr1_202912886_ENST00000340990_RGS8_chr1_182617438_ENST00000367556_length(amino acids)=385AA_BP=265
MSSHKGSVVAQGNGAPASNREADTVELAELGPLLEEKGKRVIANPPKAEEEQTCPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEG
RWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGA
VLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRADG
VAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEK

--------------------------------------------------------------
>2439_2439_3_ADIPOR1-RGS8_ADIPOR1_chr1_202912886_ENST00000340990_RGS8_chr1_182617438_ENST00000367557_length(transcript)=1503nt_BP=1104nt
CTCCGCGAGAGGGCCTAGGATTGGAGGGCCCAGGCAGAGCCCGCGAGGAGGTGACGCGGCTGCGGAGGTGACGCGGGAGGTCGCGCGCCC
CTTCCGGCGCGGGGAGGGCGCTGAAGATCGGGGCCGCTCGGCCGCAGGCCGCCTCCAGCGCCGCGGGATGTAGCGCGGGGGACCGCGGCC
CCCAGCAGAGCCCGCCTGCCCGGCTTGTCTACCATCAGAGGGAGATCTCTGCCCCCTGGGGCTGAGAGACCCCAACCTTTCCCCAAGCTG
AAGCTGCAGGGTATTGAGGTACCAGCCAGATGTCTTCCCACAAAGGATCTGTGGTGGCACAGGGGAATGGGGCTCCTGCCAGTAACAGGG
AAGCTGACACGGTGGAACTGGCTGAACTGGGACCCCTGCTAGAAGAGAAGGGCAAACGGGTAATCGCCAACCCACCCAAAGCTGAAGAAG
AGCAAACATGCCCAGTGCCCCAGGAAGAAGAGGAGGAGGTGCGGGTACTGACACTTCCCCTGCAAGCCCACCACGCCATGGAGAAGATGG
AAGAGTTTGTGTACAAGGTCTGGGAGGGACGTTGGAGGGTCATCCCATATGATGTGCTCCCTGACTGGCTAAAGGACAACGACTATCTGC
TACATGGTCATAGACCTCCCATGCCCTCCTTTCGGGCTTGCTTCAAGAGCATCTTCCGCATTCATACAGAAACTGGCAACATCTGGACCC
ATCTGCTTGGTTTCGTGCTGTTTCTCTTTTTGGGAATCTTGACCATGCTCAGACCAAATATGTACTTCATGGCCCCTCTACAGGAGAAGG
TGGTTTTTGGGATGTTCTTTTTGGGTGCAGTGCTCTGCCTCAGCTTCTCCTGGCTCTTTCACACCGTCTATTGTCATTCAGAGAAAGTCT
CTCGGACTTTTTCCAAACTGGACTATTCAGGGATTGCTCTTCTAATTATGGGGAGCTTTGTCCCCTGGCTCTATTATTCCTTCTACTGCT
CCCCACAGCCACGGCTCATCTACCTCTCCATCGTCTGTGTCCTGGGCATTTCTGCCATCATTGTGGCGCAGTGGGACCGGTTTGCCACTC
CTAAGCACCGGCAGACAAGAGCAGATGGGGTGGCTGCATTCCGTGCCTTCTTGAAGACGGAGTTCAGTGAGGAGAACCTGGAATTCTGGT
TGGCCTGTGAGGAGTTCAAGAAGACCAGGTCAACTGCAAAACTGGTCTCTAAGGCCCATAGGATCTTTGAGGAGTTTGTGGATGTGCAGG
CTCCACGGGAGGTAAACATTGACTTCCAGACCCGAGAAGCCACGAGGAAGAACCTGCAGGAGCCATCCCTGACTTGCTTTGACCAAGCCC
AAGGAAAAGTACACAGCCTCATGGAGAAAGACTCTTACCCCAGGTTCCTGAGGTCCAAAATGTACTTAGATCTGCTGTCCCAAAGCCAGA

>2439_2439_3_ADIPOR1-RGS8_ADIPOR1_chr1_202912886_ENST00000340990_RGS8_chr1_182617438_ENST00000367557_length(amino acids)=384AA_BP=265
MSSHKGSVVAQGNGAPASNREADTVELAELGPLLEEKGKRVIANPPKAEEEQTCPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEG
RWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGA
VLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRADG
VAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEK

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>2439_2439_4_ADIPOR1-RGS8_ADIPOR1_chr1_202912886_ENST00000340990_RGS8_chr1_182617438_ENST00000483095_length(transcript)=2085nt_BP=1104nt
CTCCGCGAGAGGGCCTAGGATTGGAGGGCCCAGGCAGAGCCCGCGAGGAGGTGACGCGGCTGCGGAGGTGACGCGGGAGGTCGCGCGCCC
CTTCCGGCGCGGGGAGGGCGCTGAAGATCGGGGCCGCTCGGCCGCAGGCCGCCTCCAGCGCCGCGGGATGTAGCGCGGGGGACCGCGGCC
CCCAGCAGAGCCCGCCTGCCCGGCTTGTCTACCATCAGAGGGAGATCTCTGCCCCCTGGGGCTGAGAGACCCCAACCTTTCCCCAAGCTG
AAGCTGCAGGGTATTGAGGTACCAGCCAGATGTCTTCCCACAAAGGATCTGTGGTGGCACAGGGGAATGGGGCTCCTGCCAGTAACAGGG
AAGCTGACACGGTGGAACTGGCTGAACTGGGACCCCTGCTAGAAGAGAAGGGCAAACGGGTAATCGCCAACCCACCCAAAGCTGAAGAAG
AGCAAACATGCCCAGTGCCCCAGGAAGAAGAGGAGGAGGTGCGGGTACTGACACTTCCCCTGCAAGCCCACCACGCCATGGAGAAGATGG
AAGAGTTTGTGTACAAGGTCTGGGAGGGACGTTGGAGGGTCATCCCATATGATGTGCTCCCTGACTGGCTAAAGGACAACGACTATCTGC
TACATGGTCATAGACCTCCCATGCCCTCCTTTCGGGCTTGCTTCAAGAGCATCTTCCGCATTCATACAGAAACTGGCAACATCTGGACCC
ATCTGCTTGGTTTCGTGCTGTTTCTCTTTTTGGGAATCTTGACCATGCTCAGACCAAATATGTACTTCATGGCCCCTCTACAGGAGAAGG
TGGTTTTTGGGATGTTCTTTTTGGGTGCAGTGCTCTGCCTCAGCTTCTCCTGGCTCTTTCACACCGTCTATTGTCATTCAGAGAAAGTCT
CTCGGACTTTTTCCAAACTGGACTATTCAGGGATTGCTCTTCTAATTATGGGGAGCTTTGTCCCCTGGCTCTATTATTCCTTCTACTGCT
CCCCACAGCCACGGCTCATCTACCTCTCCATCGTCTGTGTCCTGGGCATTTCTGCCATCATTGTGGCGCAGTGGGACCGGTTTGCCACTC
CTAAGCACCGGCAGACAAGAGCAGATGGGGTGGCTGCATTCCGTGCCTTCTTGAAGACGGAGTTCAGTGAGGAGAACCTGGAATTCTGGT
TGGCCTGTGAGGAGTTCAAGAAGACCAGGTCAACTGCAAAACTGGTCTCTAAGGCCCATAGGATCTTTGAGGAGTTTGTGGATGTGCAGG
CTCCACGGGAGGTAAACATTGACTTCCAGACCCGAGAAGCCACGAGGAAGAACCTGCAGGAGCCATCCCTGACTTGCTTTGACCAAGCCC
AAGGAAAAGTACACAGCCTCATGGAGAAAGACTCTTACCCCAGGTTCCTGAGGTCCAAAATGTACTTAGATCTGCTGTCCCAAAGCCAGA
GGAGGCTCAGTTAGACCTCAGAAGGGAACTCCTGGAAATCACCGGCTTTCCCCTCCACTTGCTGCCAAGATCATATTCTAATGTGAAATG
TCATAGGTGTTCAAAAGCGGTGGCATTGGGGGTGGGAGGCTGGGGGTGAGGAGGGAATGAAGGGCCATTCCAAAGTATGACCCAGCTGCC
GGAGCTTGGACTCTATTCCATTTACCCATGTTTGTGTTTTGGTTAGTGGTAGCGCCTTGCCGCTGTCACCCTTTTCTGGGTCAGCAACTT
GCCCTTCATATAATGCCTTGGGTCACCTCTGCTGAGAGGGCAGATTTGCTGTGCTAGGCTAATCTGTAAATAATGCAAATGCAATTCCCA
CCACCTCCACACCCTCCTCGGTTAGGATTCCTGACTCTCCACTTGTTGTAAATCCCTGGGAGGAATAGCTGAAAGACTTGGGCTCAACTC
TGTGATTTGTAGTGGCCAGCTCTGCTCACTGGGATCTCACAGCTTAGGAGAGAGGTTTCTGTGGAATTCCAGGTTTCTAGTTCTGTCATT
GACAGGTGACCTCTCAGAGAAGGAGTGAAATCCATGGAGTTGTTTGTTTCTTCCATTTCCATTGGACCAGTGTGAAAAACTGTGATTACT

>2439_2439_4_ADIPOR1-RGS8_ADIPOR1_chr1_202912886_ENST00000340990_RGS8_chr1_182617438_ENST00000483095_length(amino acids)=384AA_BP=265
MSSHKGSVVAQGNGAPASNREADTVELAELGPLLEEKGKRVIANPPKAEEEQTCPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEG
RWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGA
VLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRADG
VAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEK

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Fusion Gene PPI Analysis for ADIPOR1-RGS8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADIPOR1-RGS8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADIPOR1-RGS8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADIPOR1C0021361Female infertility1CTD_human
HgeneADIPOR1C0022661Kidney Failure, Chronic1CTD_human
HgeneADIPOR1C0038279Sterility, Postpartum1CTD_human
HgeneADIPOR1C0341869Subfertility, Female1CTD_human
HgeneADIPOR1C0917730Female sterility1CTD_human