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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANGPTL4-CLCN3 (FusionGDB2 ID:HG51129TG1182)

Fusion Gene Summary for ANGPTL4-CLCN3

check button Fusion gene summary
Fusion gene informationFusion gene name: ANGPTL4-CLCN3
Fusion gene ID: hg51129tg1182
HgeneTgene
Gene symbol

ANGPTL4

CLCN3

Gene ID

51129

1182

Gene nameangiopoietin like 4chloride voltage-gated channel 3
SynonymsARP4|FIAF|HARP|HFARP|NL2|PGAR|TGQTL|UNQ171|pp1158CLC3|ClC-3
Cytomap('ANGPTL4')('CLCN3')

19p13.2

4q33

Type of geneprotein-codingprotein-coding
Descriptionangiopoietin-related protein 4PPARG angiopoietin related proteinfasting-induced adipose factorhepatic angiopoietin-related proteinhepatic fibrinogen/angiopoietin-related proteinperoxisome proliferator-activated receptor (PPAR) gamma induced angiopoieH(+)/Cl(-) exchange transporter 3chloride channel 3chloride channel protein 3chloride channel, voltage-sensitive 3chloride transporter ClC-3
Modification date2020032220200313
UniProtAcc.

P51790

Ensembl transtripts involved in fusion geneENST00000301455, ENST00000393962, 
ENST00000541807, 
Fusion gene scores* DoF score3 X 3 X 2=1837 X 5 X 19=3515
# samples 337
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(37/3515*10)=-3.24792751344359
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANGPTL4 [Title/Abstract] AND CLCN3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANGPTL4(8439257)-CLCN3(170623929), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANGPTL4

GO:0043066

negative regulation of apoptotic process

10698685

HgeneANGPTL4

GO:0043335

protein unfolding

29899144

HgeneANGPTL4

GO:0051005

negative regulation of lipoprotein lipase activity

19542565|29899144

TgeneCLCN3

GO:1902476

chloride transmembrane transport

11274166



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-80-5608-01AANGPTL4chr19

8439257

-CLCN3chr4

170623929

+


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Fusion Gene ORF analysis for ANGPTL4-CLCN3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000301455ENST00000347613ANGPTL4chr19

8439257

-CLCN3chr4

170623929

+
5CDS-intronENST00000301455ENST00000360642ANGPTL4chr19

8439257

-CLCN3chr4

170623929

+
5CDS-intronENST00000301455ENST00000504131ANGPTL4chr19

8439257

-CLCN3chr4

170623929

+
5CDS-intronENST00000301455ENST00000506924ANGPTL4chr19

8439257

-CLCN3chr4

170623929

+
5CDS-intronENST00000301455ENST00000513761ANGPTL4chr19

8439257

-CLCN3chr4

170623929

+
intron-intronENST00000393962ENST00000347613ANGPTL4chr19

8439257

-CLCN3chr4

170623929

+
intron-intronENST00000393962ENST00000360642ANGPTL4chr19

8439257

-CLCN3chr4

170623929

+
intron-intronENST00000393962ENST00000504131ANGPTL4chr19

8439257

-CLCN3chr4

170623929

+
intron-intronENST00000393962ENST00000506924ANGPTL4chr19

8439257

-CLCN3chr4

170623929

+
intron-intronENST00000393962ENST00000513761ANGPTL4chr19

8439257

-CLCN3chr4

170623929

+
intron-intronENST00000541807ENST00000347613ANGPTL4chr19

8439257

-CLCN3chr4

170623929

+
intron-intronENST00000541807ENST00000360642ANGPTL4chr19

8439257

-CLCN3chr4

170623929

+
intron-intronENST00000541807ENST00000504131ANGPTL4chr19

8439257

-CLCN3chr4

170623929

+
intron-intronENST00000541807ENST00000506924ANGPTL4chr19

8439257

-CLCN3chr4

170623929

+
intron-intronENST00000541807ENST00000513761ANGPTL4chr19

8439257

-CLCN3chr4

170623929

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ANGPTL4-CLCN3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ANGPTL4-CLCN3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:8439257/:170623929)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CLCN3

P51790

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: [Isoform 1]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874). {ECO:0000250|UniProtKB:P51791, ECO:0000303|PubMed:29845874}.; FUNCTION: [Isoform 2]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. {ECO:0000269|PubMed:11967229}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ANGPTL4-CLCN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANGPTL4-CLCN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANGPTL4-CLCN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANGPTL4-CLCN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANGPTL4C0006142Malignant neoplasm of breast1CTD_human
HgeneANGPTL4C0007097Carcinoma1CTD_human
HgeneANGPTL4C0010054Coronary Arteriosclerosis1CTD_human
HgeneANGPTL4C0015695Fatty Liver1CTD_human
HgeneANGPTL4C0020557Hypertriglyceridemia1CTD_human
HgeneANGPTL4C0024232Lymphatic Metastasis1CTD_human
HgeneANGPTL4C0027626Neoplasm Invasiveness1CTD_human
HgeneANGPTL4C0027627Neoplasm Metastasis1CTD_human
HgeneANGPTL4C0028754Obesity1CTD_human
HgeneANGPTL4C0205696Anaplastic carcinoma1CTD_human
HgeneANGPTL4C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneANGPTL4C0205698Undifferentiated carcinoma1CTD_human
HgeneANGPTL4C0205699Carcinomatosis1CTD_human
HgeneANGPTL4C0242339Dyslipidemias1CTD_human
HgeneANGPTL4C0598784Dyslipoproteinemias1CTD_human
HgeneANGPTL4C0678222Breast Carcinoma1CTD_human
HgeneANGPTL4C1257931Mammary Neoplasms, Human1CTD_human
HgeneANGPTL4C1458155Mammary Neoplasms1CTD_human
HgeneANGPTL4C1956346Coronary Artery Disease1CTD_human
HgeneANGPTL4C2711227Steatohepatitis1CTD_human
HgeneANGPTL4C4704874Mammary Carcinoma, Human1CTD_human
TgeneC0017638Glioma1CTD_human
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC0235874Disease Exacerbation1CTD_human
TgeneC0259783mixed gliomas1CTD_human
TgeneC0555198Malignant Glioma1CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC2931822Nasopharyngeal carcinoma1CTD_human